Abstract: Novel 1-aryloxy-3-carbamoylalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(2-cyanophenoxy)-3-.beta.-(N-2-furfurylcarbamoyl)ethylamino-2-propanol.
Type:
Grant
Filed:
November 26, 1976
Date of Patent:
September 19, 1978
Assignee:
Imperial Chemical Industries Limited
Inventors:
Michael Stewart Large, Leslie Harold Smith
Abstract: Novel 1-aryl-2-carbamoylalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(4-methanesulphonamidophenyl)-2-(.beta.-N-2-furfurylcarbamoylethylamino) ethanol.
Type:
Grant
Filed:
November 26, 1976
Date of Patent:
April 25, 1978
Assignee:
Imperial Chemical Industries Limited
Inventors:
Michael Stewart Large, Leslie Harold Smith
Abstract: Indolyl methylene leuco dyestuffs of the formula ##STR1## wherein X.sub.1 and X.sub.2 independently of the other, represent alkyl with 2 to 12 carbon atoms, alkenyl with at most 12 carbon atoms or phenylalkyl with 1 to 4 carbon atoms in the alkyl part, Y.sub.1 and Y.sub.2 independently of the other, represent hydrogen, alkyl with 1 to 12 carbon atoms or phenyl, Z represents alkyl with 1 to 12 carbon atoms, alkenyl with at most 12 carbon atoms, aryl, aralkyl or a heterocyclic residue and the rings A and B may be further substituted by cyano, nitro, halogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms or acyl with 1 to 8 carbon atoms, said methylene compounds are particularly useful as slow developing color formers in pressure-sensitive recording material and exhibit good light and air stability.
Type:
Grant
Filed:
January 23, 1975
Date of Patent:
February 7, 1978
Assignee:
Ciba-Geigy Corporation
Inventors:
Robert Garner, John B. Henshall, Jean-Claude Petitpierre
Abstract: N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.
Type:
Grant
Filed:
January 19, 1977
Date of Patent:
January 3, 1978
Assignees:
Mitsubishi Chemical Industries Ltd., Shosuke Okamoto