Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.

Abstract: A process for preparing compounds of the formula I in which R1 is hydrogen, an aliphatic group having 1-8 carbon atoms, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or a cyclic ring system having 3-14 ring atoms, and R2 is hydrogen, an aliphatic group having 1-8 carbon atoms, or R1 and R2 together with the carbon atom to which they are bound form a cyclic or bicyclic ring system having 3-14 ring atoms, comprises the preparation of compounds of the formula II  in which R3 and R4 are readily detachable groups and R1 and R2 are as defined above, as starting materials or intermediates and the cyclization of these under suitable reaction conditions to give compounds of the formula I.

Abstract: The present invention provides an insecticidal or acaricidal composition having an excellent pesticidal effect and a high safety, containing, as an active ingredient, a pyrazolyl compound of the following general formula (I): 1

Abstract: There is disclosed a silver halide color photographic light-sensitive material that is improved in such aspects as fastness of dye images, color reproduction, cyan stain, processing cyan color contamination, and the like, by the combination use of a phenidone compound having a specific structure as in the following general formula (VIII) and a pyrrolotriazole cyan coupler. The phenidone compound (VIII) can be produced industrially in low cost, by reacting an &agr;-alkyl or alkenyl acrylate with a compound represented by the following general formula (VII): wherein, R4, R5, R6, R7, R8, and R9, each represent a hydrogen atom, an alkyl group, or the like; R2a represents an alkyl group having 6 to 30 carbon atoms, or the like.

Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.

Abstract: Benzamidoxime derivatives of the formula I 1

Abstract: The present invention relates to novel substituted 3-benzylpyrazoles of the formula I

Abstract: Compounds of formula I wherein W is optionally substituted alkylene; Y is N or CRa; Ra is hydrogen, halogen or alkyl; R1n represents hydrogen or 1 to 4 substituents; R2 is hydrogen, nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, alkylthio or alkoxycarbonyl; R3 is optionally substituted alkyl, cycloalkyl, aryl or hetaryl; A is N—OR4, CH—OR4, CH—SR4 or CHR5; R4 is alkyl or haloalkyl; R5 is halogen, alkyl or haloalkyl; methods and intermediates for their preparation. The compounds and compositions comprising them are useful for combating animal pests and harmful fungi.

Abstract: This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, where the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and the compounds of formula I.

Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.

Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

Abstract: 2-Benzoylcyclohexane-1,3-diones of formula I : where: R1 and R2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, —OR3, —OCOR3, —OSO2R3, —S(O)nR3 (n=0, 1, 2), —SO2OR3, —SO2N(R3)2, —NR3SO2R3 or —NR3COR3; R3 is hydrogen or optionally substituted alkyl, haloalkyl, alkenyl, alkynyl, phenyl or phenylalkyl; Q is optionally substituted cyclohexane-2-yl-1,3-dione; X1 is optionally substituted alkylene, propenylene, alkenylene or alkynylene; R4 is hydrogen or optionally substituted alkyl, alkenyl, alkynyl, phenyl, phenylalkyl; Het is a three- to six-membered, optionally substituted heterocyclic or heteroaromatic group; and agriculturally useful salts thereof, processes and intermediates for preparing compounds of formula I, compositions comprising them, and the use of the compounds of formula I and the compositions comprising them for controlling harmful plants are described.

Abstract: A “one-pot” process is described herein for the production of pyrazole compounds of general formula (II) comprising the steps of reacting a compound of general formula (III) with an acylating agent in the presence of a base and an optional activating agent followed by the addition of a hydrazine compound in situ.

Abstract: Amino pyrazole derivatives of the formula: 1

Abstract: The present invention relates to compounds of the formula 1

Abstract: Substituted 3-phenylpyrazoles of the formula I Salts thereof and use as herbicides.

Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.

Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.

Abstract: This invention relates to compounds having the Formula I: 1

Abstract: Compounds of the formula: 1

Abstract: The invention relates to a method for the production of 1-substituted 5-hydroxypyrazoles of formula (I) wherein R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or C1-C4-alkoxy, whereby these groups can be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or a cyclic ring system with 3-14 ring atoms, by reacting a) an alkylvinylether of general formula (III) wherein R2 is C1-C6-alkyl or C3-C6-cycloalkyl, with phosgene (IVa), “diphosgene” (IVb) or “triphosgene” (IVc) to form acid chlorides of formula (V), b) transforming said acid chlorides by eliminating hydrogen chloride into the corresponding 3-alkoxyacrylic acid chloride of formula (VI) and c) reacting said acid chloride with hydrazines of formula (VII) wherein R1 has the above cited meaning, to form 5-hydroxypyrazoles of formula (I).

Abstract: Compounds having the formula 1

Abstract: The method for temporarily coloring and later decolorizing hair includes applying a colorant to the hair, which contains a monomethine or polymethine dye of formula (Ia/Ib), or a salt thereof, W=L−V′(Ia)&rlarr2;W′−L=V (Ib), wherein W=L−V′ and W′=L−V are tautomers, W and V are each a substituted five-member or six-member heterocyclic ring, each of which is a substituted pyrazolone, substituted pyridone, substituted dioxothiazoline, substituted rhodanine, substituted dioxoimidazolidine or substituted barbituric acid; wherein L represents —[—CH═CH—]m—CR═[═CH—CH═]n═ and R is hydrogen, a phenyl group, a halogen atom, a methyl group or a carboxamido group, and wherein m and n are each 0, 1 or 2, but n+m≦2; then allowing the colorant to act for from 10 to 45 min at 20 to 50° C.

Abstract: The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in the presence of an acid acceptor and in the presence of a diluent at temperatures between 0° C. and 150° C. and, in a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphon-amides and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides obtained in the first step are as pure substances or as mixtures with ammonia in the presence of a diluent reacted at a temperature between 100° C. and 200° C. The invention furthermore relates to novel intermediates of the process.

Abstract: Hydrazide fixed to a resin represented by the following formula: P—Q—CO—NH—NH2  (I) where P represents a main chain of a resin polymer and Q represents a hydrocarbon side chain optionally having a substituent which may be bonded via a heteroatom, and a hydrazone derived therefrom and fixed to a resin P—Q—CO—NH—N═CH—R1  (II) are provided, and solid phase synthesis of pyrazolone is conducted using the same, thereby enabling synthesis of pyrazolones by the application of the Mannich type reaction based on the solid phase synthesis and efficient construction of libraries for various kinds of them.

Abstract: Benzylidenepyrazolones of the formula I, Useful as herbicides.

Abstract: The invention relates to a novel process for producing thereof hydroxyarenes of the general formula (I) in which n represents the numbers 1, 2, 3 or 4, R represents cyano, carboxyl, formyl, nitro, halogen or represents alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylcarbonyl or alkoxycarbonyl, each of which is optionally substituted, and Z represents hydrogen, cyano, nitro, halogen, alkyl, halogenoalkyl, or represents monocyclic or bicyclic, saturated or unsaturated heterocyclyl, heterocyclylamino or heterocyclylimino, each of which is optionally substituted, characterized in that halogenoarenes of the general formula (II) in which n, R and Z are each as defined above and X represents halogen are reacted with 3-hydroxy-propionitrile of the formula (III), HO—CH2CH2—CN  (III), if appropriate in the presence of a reaction auxiliary and if appropriate in the presence of a diluent, at temperatures between 0° C. and 100° C.