The Polycyclo Ring System Has At Least Six Cyclos, And Has Either A Ring Carbon That Is Shared By Three Of The Cyclos Or Has A Ring Chalcogen Patents (Class 548/417)
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Publication number: 20120097924Abstract: A heterocyclic compound represented by a general Formula 1 and an organic light-emitting device including the heterocyclic compound. In some embodiments the heterocyclic compound of Formula 1 may be used as a light-emitting material, a hole transporting material, or an electron transporting material. The heterocyclic compound of Formula 1 having a heterocyclic group in the molecules thereof has a high glass transition temperature (Tg) or a high melting point due to the inclusion of the heterocyclic group. Thus, the heterocyclic compound has high heat resistance against Joule's heat generated in an organic layer, between organic layers, or between an organic layer and a metal electrode when light emission occurs, and has high durability in high-temperature environments. An organic light-emitting device manufactured using the heterocyclic compound of Formula 1 has high durability when stored or operated.Type: ApplicationFiled: April 1, 2011Publication date: April 26, 2012Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Young-Kook KIM, Seok-Hwan HWANG, Hye-Jin JUNG, Jin-O LIM, Sang-Hyun HAN, Yoon-Hyun KWAK, Sun-Young LEE, Jong-Hyuk LEE, Sung-Chul KIM
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Publication number: 20120060926Abstract: The present invention discloses an inverted organic photovoltaic cell comprising a polymerizable fullerene interlayer adapted to enhance the device performance and lifetime. The polymerizable fullerene derivative comprises a fullerene core, a bridging functional group and a polymerizable functional group. The fullerene core can be either C60 or C70, and the bridging functional group comprises a cyclic hydrocarbon or a heterocyclic ring. The polymerizable functional group comprises a thermally polymerizable functional group or a photochemically polymerizable functional group.Type: ApplicationFiled: March 11, 2011Publication date: March 15, 2012Applicant: NATIONAL CHIAO TUNG UNIVERSITYInventors: CHAIN-SHU HSU, YEN-JU CHENG, CHAO-HSIANG HSIEH, PEI-JUNG LI
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Publication number: 20120012826Abstract: An amine compound represented by Formula 1 below and an organic light-emitting device including an organic layer containing the same: the compound of Formula 1 may be suitable as a hole injecting material, a hole transporting material, or a light-emitting material of an organic light-emitting device. Like the compound of Formula 1, a compound having a hetero ring in its molecular structure has a high glass transition temperature (Tg) or a high melting point due to the inclusion of the hetero ring. Accordingly, when light emission occurs, such a compound has high resistance against Joules' heat generated in an organic layer. between organic layers, and between an organic layer and a metallic electrode, and has high durability in high-temperature environments.Type: ApplicationFiled: July 12, 2011Publication date: January 19, 2012Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Young-Kook KIM, Seok-Hwan HWANG, Hye-Jin JUNG, Jin-O LIM, Jong-Hyuk LEE
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Publication number: 20110308592Abstract: The present invention relates to an organic solar cell with a photoactive region which comprises at least one organic donor material in contact with at least one organic acceptor material, wherein the donor material and the acceptor material form a donor-acceptor heterojunction and wherein the photoactive region comprises at least one substituted perylene.Type: ApplicationFiled: June 17, 2011Publication date: December 22, 2011Applicant: BASF SEInventors: Martin KÖNEMANN, Jae Hyung HWANG, Gabriele MATTERN, Regina HÖH, Christian DÖRR
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Publication number: 20110253944Abstract: The present invention relates to a novel polycyclic aromatic organic semiconductor compound having a polycyclic aromatic core, a method for preparing the same, and electronic, optical or electro-optical devices such as an organic semiconductor composition, organic semiconductor thin film, organic field effect transistor and solar cell containing the compound. The novel organic semiconductor compound according to the present invention has high crystallinity and control capability, and facilitates control of doping conditions in the manufacture of organic semiconductor element so that it can be used for diverse applications. The compound can be mass-produced at low cost and has high solubility in organic solvents so that a liquid phase process can be applied to the manufacture of semiconductor elements and the like, thus enabling the mass-production of semiconductor elements and solar cells at low cost.Type: ApplicationFiled: December 23, 2009Publication date: October 20, 2011Applicant: LUMINANO CO., LTD.Inventors: Sung Hwan Han, Cheon Gyu Cho
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Publication number: 20110227002Abstract: Disclosed herein are an aromatic imide-based dispersant for CNTs and a carbon nanotube composition comprising the same. Having an aromatic ring structure advantageously realizing adsorption on carbon nanotubes, the dispersant, even if used in a small amount, can disperse a large quantity of carbon nanotubes.Type: ApplicationFiled: June 3, 2011Publication date: September 22, 2011Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Hyo Sug LEE, Jae Young CHOI, Seon Mi YOON, Hyuk Soon CHOI, Kwang Hee KIM
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Publication number: 20110166362Abstract: Discloses is a compound represented by the formula (1): wherein a ring structure A and a ring structure B independently represent an aromatic ring which may be substituted, or a heterocyclic ring which may be substituted; a ring structure C represents a benzene ring which may be substituted, a hetero[3,2-b]heterole ring, or a benzo[1,2-b:4,5-b?]diheterole ring which may be substituted; W, X, Y and Z independently represent a sulfur atom, an oxygen atom, a selenium atom, a tellurium atom, SO2, (R1)—C—(R2), (R2)—Si—(R4), or N—(R5), and at least one of W, X, Y and Z is N—(R5); R1, R2, R3, R4 and R5 independently represent a hydrogen atom, a substituent i, a substituent ii, an aryl group which may be substituted with halogen, or a heteroaryl group which may be substituted with halogen, the substituent i is a group selected from Group P shown below, the substituent ii is a group selected from Group P shown below which group is substituted, and Group P consists of an alkyl group, an alkoxy group, an alkyl-subsType: ApplicationFiled: September 7, 2009Publication date: July 7, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Yasuo Miyata, Eiji Yoshikawa
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Publication number: 20110049488Abstract: Embodiments of the present invention are directed to heterocyclic compounds and organic light-emitting devices including the heterocyclic compounds. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltages, high luminance and long lifespans.Type: ApplicationFiled: August 17, 2010Publication date: March 3, 2011Inventors: Young-Kook Kim, Seok-Hwan Hwang, Yoon-Hyun Kwak, Hye-Jin Jung, Jong-Hyuk Lee, Jin-O Lim, Hee-Joo Ko
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Publication number: 20110001093Abstract: Disclosed is an organic photoelectric converter having a layer containing a fullerene derivative represented by the formula (1) below. (In the formula (1), m represents an integer of 1-6; n represents an integer of 1-4; p represents an integer of 0-5; r represents an integer of 0-4; and Q represents a group represented by the formula (2) or (3) below. When there are a plurality of m's, they may be the same as or different from each other. In the formulae (2) and (3), R1 and R2 independently represent a halogen atom, an alkyl group, an alkoxy group or an aryl group, and a hydrogen atom contained in these groups may be substituted by a halogen atom; q represents an integer of 0-7; and v represents an integer of 0-5. When there are a plurality of R1's, they may be the same as or different from each other. When there are a plurality of R2's, they may be the same as or different from each other.Type: ApplicationFiled: September 11, 2008Publication date: January 6, 2011Applicants: SUMITOMO CHEMICAL COMPANY LIMITED, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventors: Toshiyuki Itoh, Yasunori Uetani
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Publication number: 20100297556Abstract: Organic coating compositions, particularly antireflective coating compositions, are provided that comprise that comprise a diene/dienophile reaction product. Preferred compositions of the invention are useful to reduce reflection of exposing radiation from a substrate back into an overcoated photoresist layer and/or function as a planarizing, conformal or via-fill layer.Type: ApplicationFiled: February 8, 2010Publication date: November 25, 2010Applicant: Rohm and Haas Electronic Materials LLCInventors: James F. Cameron, Jin Wuk Sung, John P. Amara, Gregory P. Prokopowicz, David A. Valeri
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Publication number: 20100297009Abstract: Self-assembled, closed and hollow chemical multimer structures having a dodecahedral morphology, composed of chemical monomers having a structurally symmetric core which possess a 5-fold rotational symmetry, are provided. Also provided are methods of creating such chemical monomers, methods of creating such chemical multimer structures and compositions comprising these chemical multimer structures. Also provided are uses of these chemical multimer structures in applications such as drug delivery, imaging, immunization, formation of plastic crystals and nanoparticle matrices and other medical and material science applications.Type: ApplicationFiled: March 13, 2008Publication date: November 25, 2010Inventors: Arthur Olson, Ehud Keinan
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Patent number: 7833756Abstract: Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.Type: GrantFiled: July 8, 2008Date of Patent: November 16, 2010Assignee: Applied Biosystems, LLCInventors: Scott C. Benson, Joe Y. L. Lam, Steven Michael Menchen
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Publication number: 20100267704Abstract: This invention pertains to a class of autophagy inducing compounds that treat diseases caused by misfolded protein aggregates and a screening method for identifying these compounds.Type: ApplicationFiled: October 10, 2008Publication date: October 21, 2010Applicants: President an Fellows of Harvard Colege, Shangha Institute of Organic Chemistry Chineesse Academy of SciencesInventors: Junying Yuan, Dawei Ma, Lihong Zhang
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Patent number: 7816673Abstract: A heteroacene compound includes a di-thieno-benzo-thieno-thiophene derivative, in which all six rings may be fused together, an organic thin film including the same, and an electronic device that includes the thin film as a carrier transport layer. The compound of example embodiments may have a compact planar structure to thus realize improved solvent solubility and processability. When the compound is applied to electronic devices, a deposition process or a room-temperature solution process may be applied, and as well, intermolecular packing and stacking may be efficiently realized, resulting in improved electrical properties, including increased charge mobility.Type: GrantFiled: August 8, 2007Date of Patent: October 19, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Jong Il Park, Eun Jeong Jeong, Sang Yoon Lee, Bang Lin Lee, Kook Min Han
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Publication number: 20100216970Abstract: This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation.Type: ApplicationFiled: May 3, 2010Publication date: August 26, 2010Inventors: Thomas E. Johnson, Billy T. Fowler
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Patent number: 7771695Abstract: Separation of carbon nanotubes or fullerenes according to diameter through non-covalent pi-pi interaction with molecular clips is provided. Molecular clips are prepared by Diels-Alder reaction of polyacenes with a variety of dienophiles. The pi-pi complexes of carbon nanotrubes with molecular clips are also used for selective placement of carbon nanotubes and fullerenes on substrates.Type: GrantFiled: July 21, 2006Date of Patent: August 10, 2010Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Cherie R. Kagan, Rudolf Tromp
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Publication number: 20100168439Abstract: Self-assembling multimeric physical models of closed polyhedral structures made of structurally symmetric units, and which mimic the structure and self-assembly characteristics of naturally occurring systems such as viral capsids, are provided. Also provided are methods of creating structurally symmetric units, kits for forming self-assembling physical models of polyhedral structures, and methods of forming the same.Type: ApplicationFiled: March 13, 2008Publication date: July 1, 2010Inventor: Arthur J. Olson
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Publication number: 20100051928Abstract: An organic electroluminescence device includes: a pair of electrodes; and at least one organic layer including a light emitting layer, the light emitting layer being provided between the pair of electrodes, wherein at least one layer of the at least one organic layer contains a compound represented by formula (1): wherein each of Z11 and Z12 independently represents an aromatic heterocyclic ring or an aromatic hydrocarbon ring; R11 represents a hydrogen atom or a substituent, provided that a plurality of R11s are the same or different; m represents an integer of 1 or more; and L1 represents a single bond or an m-valent linking group and is linked to any one of C atoms in R11, Z11 and Z12, provided that when m is 1, L1 does not exist.Type: ApplicationFiled: September 4, 2009Publication date: March 4, 2010Applicant: FUJIFILM CORPORATIONInventor: Eiji FUKUZAKI
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Publication number: 20100047178Abstract: The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.Type: ApplicationFiled: July 28, 2006Publication date: February 25, 2010Applicant: QUEST PHARMATECH INC.Inventors: Sanjay K. Sharma, Thomas Woo, Selvaraj Naicker
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Publication number: 20100019205Abstract: The liquid fullerene derivative according to the present invention contains a fullerene moiety, a benzene ring bonded to the fullerene moiety, and first to third alkyl substituents R1, R2 and R3 bonded to 2-, 4- and 6-positions of the benzene ring, respectively, and the first to third alkyl substituents R1, R2 and R3 each contain at least 12 carbon atoms. The liquid fullerene derivative which is liquid at room temperature without requiring a solvent and easily exhibits the function of the fullerene itself, a method for producing the same, and a device using the same are provided.Type: ApplicationFiled: July 5, 2007Publication date: January 28, 2010Inventors: Takashi Nakanishi, Tsuyoshi Michinobu, Jonathan P. Hill, Katsuhiko Ariga
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Publication number: 20090068751Abstract: Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.Type: ApplicationFiled: July 8, 2008Publication date: March 12, 2009Applicant: Applied Biosystems Inc.Inventors: Scott C. BENSON, Joe Y.L. Lam, Steven Michael Menchen
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Publication number: 20080242870Abstract: Aromatic molecules that can be used as sensors are described. The aromatic sensors include a polycyclic aromatic hydrocarbon core with a five-membered imide rings fused to the core and at least two pendant aryl groups. The aromatic sensor molecules can detect target analytes or molecular strain as a result of changes in their fluorescence, in many cases with on-off behavior. Aromatic molecules that fluoresce at various frequencies can be prepared by altering the structure of the aromatic core or the substituents attached to it. The aromatic molecules can be used as sensors for various applications such as, for example, the detection of dangerous chemicals, biomedical diagnosis, and the detection of damage or strain in composite materials. Methods of preparing aromatic sensor molecules are also described.Type: ApplicationFiled: December 14, 2007Publication date: October 2, 2008Applicant: Ohio Aerospace InstituteInventors: Michael A. Meador, Daniel S. Tyson, Ulvi F. IIan
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Patent number: 7414069Abstract: Three new alkaloids, Hirsutellones A, B, and C, are produced in cultures of fungus such as Hirsutella nivea strain BCC 2594 and Trichoderma sp. strain BCC 7579. The Hirsutellones exhibited potent growth inhibitory activity against Mycobacterium tuberculosis (H37Ra strain) with an MIC value of 0.78 ?g/ml, while showing weak or no cytotoxicity to mammalian cells. Therefore, Hirsutellones and pharmaceutical compositions containing Hirsutellones may be useful for the treatment of tuberculosis. Also described herein are methods of isolating the Hirsutellones.Type: GrantFiled: November 21, 2005Date of Patent: August 19, 2008Assignee: National Center for Genetic Engineering & Biotechnology, National Science & Technology Development AgencyInventors: Masahiko Isaka, Nigel Leslie Hywel-Jones, Sayanh Somrithipol, Kanyawim Kirtikara, Prasit Palittapongarnpim, Yodhathai Thebtaranonth
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Patent number: 7402681Abstract: A compound composed of a plurality of optionally substituted indolocarbazole moieties which are the same or different from each other.Type: GrantFiled: June 27, 2005Date of Patent: July 22, 2008Assignee: Xerox CorporationInventors: Beng S. Ong, Yu Qi, Yiliang Wu, Yuning Li
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Publication number: 20080124455Abstract: Provided are an organic light emitting compound represented by Formula 1 below, an organic light emitting device comprising the same, and a method of manufacturing the organic light emitting device: where CY1 and CY2 are each independently a fused C6-C50 aromatic ring, Ar1 is a substituted or unsubstituted C6-C50 arylene group, Ar2, Ar3, Ar4, and Ar5 are each independently a substituted or unsubstituted C6-C50 aryl group, m and n are independently 0-3, and R1 and R2 are substituent groups. An organic light emitting device comprising the organic light emitting compound has low turn-on voltage, high efficiency, high color purity and high luminance.Type: ApplicationFiled: June 22, 2007Publication date: May 29, 2008Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Dong-woo SHIN, Eun-sil HAN, Woon-jung PAEK, Yi-yeol LYU, O-hyun KWON, Myeong-suk KIM, Byoung-ki CHOI, Jhun-mo SON, Young-mok SON
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Publication number: 20080004326Abstract: Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.Type: ApplicationFiled: October 17, 2002Publication date: January 3, 2008Inventors: Cesar Sanchez Reillo, Alfredo Fernandez Brana, Jose Antonio Salas Fernandez, Carmen Mendez Fernandez
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Patent number: 7294646Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.Type: GrantFiled: June 13, 2003Date of Patent: November 13, 2007Assignee: Merck & Co. Inc.Inventors: Maria L. Garcia, Michael A. Goetz, Gregory J. Kaczorowski, Owen B. McManus, Richard L. Monaghan, William R. Strohl, Jan S. Tkacz
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Patent number: 7288650Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.Type: GrantFiled: February 2, 2006Date of Patent: October 30, 2007Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Dandu R. Reddy, Jasbir Singh, Rabindranath Tripathy, Ted Underiner
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Patent number: 7241779Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.Type: GrantFiled: December 22, 2004Date of Patent: July 10, 2007Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Allison L. Zulli, Dandu R. Reddy, Ming Tao, Theodore L. Underiner
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Patent number: 7230026Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.Type: GrantFiled: February 8, 2006Date of Patent: June 12, 2007Assignee: Cephalon, Inc.Inventors: Diane E. Gingrich, Robert L. Hudkins
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Patent number: 7227019Abstract: The present invention relates to a method for making an indolopyrrolocarbazole of the general formula [I], where the method includes the step of reacting a bisindolylmaleimide compound with an oxidizing agent in the presence of an oxygen containing gas at a temperature and for a time sufficient to yield the indolopyrrolocarbazole compound of the general formula [I].Type: GrantFiled: September 13, 2002Date of Patent: June 5, 2007Assignee: Bristol-Myers Squibb CompanyInventor: Jianji Wang
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Patent number: 7202255Abstract: Compounds of formula (I): wherein: A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, R2 represents a hydrogen atom and in that case: R3 represents a group selected from a hydrogen atom and the groups linear or branched (C1–C6)alkyl, aryl, aryl-(C1–C6)alkyl (in which the alkyl moiety is linear or branched) and SO2CF3, or R2 and R3 form a bond, R1 represents a group selected from a hydrogen atom and the groups linear or branched (C1–C6)alkyl, aryl and aryl-(C1–C6)alkyl (in which the alkyl moiety is linear or branched) or a linear or branched (C1–C6)alkylene chain, Z1 and Z2 each represent a hydrogen atom or Z1 and Z2, together with the carbon atoms carrying them, form a phenyl group. Medicaments.Type: GrantFiled: October 17, 2003Date of Patent: April 10, 2007Assignee: Les Laboratoires ServierInventors: Gerard Coudert, Nathalie Ayerbe, Franck Lepifre, Sylvain Routier, Daniel-Henri Caignard, Pierre Renard, John Hickman, Alain Pierre, Stephane Leonce
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Patent number: 7169775Abstract: Amino methyl imidazoles of Formula I are provided: wherein R, R1, R2, R3, R4, R5, and R6 are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.Type: GrantFiled: August 21, 2003Date of Patent: January 30, 2007Assignee: Neurogen CorporationInventors: Andrew Thurkauf, He Zhao, Suoming Zhang, Yang Gao
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Patent number: 7169802Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.Type: GrantFiled: December 22, 2004Date of Patent: January 30, 2007Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Allison L. Zulli, Dandu R. Reddy, Diane E. Gingrich, Ming Tao, Nadine C. Becknell, James L. Diebold, Theodore L. Underiner
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Patent number: 7163956Abstract: This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fullerene core; (ii) from 1 to 18 —X3 groups bonded to the fullerene core; (iii) from 1 to 6 —X4— groups bonded to the fullerene core; or (iv) from 1 to 6 dendrons bonded to the fullerene core.Type: GrantFiled: October 7, 2004Date of Patent: January 16, 2007Assignee: C Sixty Inc.Inventors: Stephen R. Wilson, Yi-Zhen Hu, Tong Zhu, Russ Lebovitz
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Patent number: 7122679Abstract: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.Type: GrantFiled: May 8, 2001Date of Patent: October 17, 2006Assignee: Cephalon, Inc.Inventors: Mark A. Ator, Ron Bihovsky, Sankar Chatterjee, Derek Dunn, Robert L. Hudkins
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Patent number: 7115613Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.Type: GrantFiled: March 26, 2003Date of Patent: October 3, 2006Assignee: Cephalon, Inc.Inventors: Diane E. Gingrich, Robert L. Hudkins
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Patent number: 7109229Abstract: The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).Type: GrantFiled: September 24, 2001Date of Patent: September 19, 2006Assignee: Eli Lilly and CompanyInventors: Thomas Albert Engler, Kelly Wayne Furness, Sushant Malhotra, Stephen Lyle Briggs, Harold Burns Brooks, David K yes Clawson, Concepcion Sanchez-Martinez, Faming Zhang, Guoxin Zhu
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Patent number: 7074793Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.Type: GrantFiled: January 12, 2004Date of Patent: July 11, 2006Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Dandu R. Reddy, Jasbir Singh, Rabindranath Tripathy, Ted Underiner
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Patent number: 7038025Abstract: A novel metal complex of a heterocyclic aromatic compound which shows a low activation energy, is stabilized structurally, is capable of modulation of the structure thereof, and capable of preferably functioning as a molecular device in technological fields. The metal complex of a heterocyclic aromatic compound comprises a transition metal (for example, silver ion) as a central atom, and basic ligands comprised of a 5-membered heterocyclic aromatic compound (for example, pyrrole rings), in which the position of the central atom can be changed by an internal factor such as transfer of an electric charge or by an external factor such as application of an electric field, a change in acidity of the surrounding environment, etc., whereby the number of atoms (or the number of electrons) relating to the coordination ability can be modulated, and, upon polymerization, the conformation can be modulated depending on the position of the central atom.Type: GrantFiled: December 18, 2002Date of Patent: May 2, 2006Assignee: Sony CorporationInventors: Eriko Matsui, Yuriko Kaino, Toshiyuki Kunikiyo, Yoshifumi Mori, Tatsushiro Hirata
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Patent number: 7018431Abstract: Sulfonated diarylrhodamine compounds are useful as fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides. The compounds find particular application in the area of fluorescent nucleic acid analysis, e.g., automated DNA sequencing and fragment analysis, detection of probe hybridization in hybridization arrays, detection of nucleic acid amplification products, and the like.Type: GrantFiled: June 24, 2003Date of Patent: March 28, 2006Assignee: Applera CorporationInventors: Steven M. Menchen, Scott C. Benson, Joe Y. L. Lam, Weiguo Zhen, Daqing Sun, Barnett B. Rosenblum, Shaheer H. Khan, Meng Taing
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Patent number: 7008568Abstract: A photochromic naphthopyran displays good color distribution when the naphthopyran has a central nucleus of the formula: wherein F is a 5-member, 6-member, or 7-member heterocyclic ring group having only one heteroatom, the heteroatom selected from the group consisting of oxygen, sulfur, and nitrogen, the 2,3 or 3,2 positions of the heterocyclic ring fused to the g, h, or i side; R1 and R2 are the atoms or groups providing photochromic properties to the naphthopyran.Type: GrantFiled: November 20, 2001Date of Patent: March 7, 2006Assignee: Vision-Ease Lens, Inc.Inventor: Xuzhi Qin
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Patent number: 6841567Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.Type: GrantFiled: February 10, 2000Date of Patent: January 11, 2005Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Dandu R. Reddy, Jasbir Singh, Rabindranath Tripathy, Ted Underiner
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Publication number: 20040248892Abstract: The present invention relates to a method for making an indolopyrrolocarbazole compound of the general formula [I], where the method includes the step of reacting a bisindolylmaleimide compound with an oxidizing agent in the presence of an oxygen containing gas at a temperature and for a time sufficient to yield the indolopyrrolocarbazole compound of the general formula [I]. Methods of making rebeccamycin analogs using the indolopyrrolocarbazole compound are also provided.Type: ApplicationFiled: July 21, 2004Publication date: December 9, 2004Inventor: Jianji Wang
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Publication number: 20040242508Abstract: Compound of formula (I): 1Type: ApplicationFiled: April 16, 2004Publication date: December 2, 2004Inventors: Michelle Prudhomme, Christelle Marminon, Pascale Moreau, John Hickman, Alain Pierre, Bruno Pfeiffer, Pierre Renard, Jean-Guy Bizot-Espiard
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Patent number: 6806223Abstract: The present invention relates to novel singlet oxygen catalysts useful for the production of specialty chemicals. The catalysts include a core material selected from amine coated polymeric beads, amine coated glass beads and multi-generational dendrimers to which condensed carbon molecules are bonded. These catalysts may in turn give rise to other solid phase heterogeneous catalysts useful for stereoselective or regioselective reactions, by way of non-limiting example.Type: GrantFiled: April 19, 2002Date of Patent: October 19, 2004Assignee: Central Michigan University Board of TrusteesInventor: Anton W. Jensen
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Patent number: 6790963Abstract: An E-isomeric fulleropyrrolidine compound of formula (I): is disclosed. Also disclosed is a method for preparing and polymers prepared from such a compound.Type: GrantFiled: July 24, 2002Date of Patent: September 14, 2004Inventors: Long Y. Chiang, Vijayaraj Anantharaj
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Publication number: 20040127540Abstract: The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.Type: ApplicationFiled: December 15, 2003Publication date: July 1, 2004Applicant: Wyeth Holdings CorporationInventors: Haiyin He, Hui Yang, Ramunas Bigelis
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Patent number: 6692538Abstract: The invention relates to the use of novel indole compounds as direct dyes in compositions intended for dyeing keratin materials, and, for example, compositions intended for dyeing human keratin fibers and including the hair, and in cosmetic compositions intended for making up the skin, the nails and the lips, to the dye compositions or make-up compositions comprising them and to the direct dyeing process using them, and processes of manufacturing said novel indole compounds.Type: GrantFiled: May 3, 2002Date of Patent: February 17, 2004Assignee: L'Oréal S.A.Inventors: Nicole Bonaventure, Patrick Gilard, Gilles Barre, Michel Dubois
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Publication number: 20030220387Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.Type: ApplicationFiled: May 7, 2003Publication date: November 27, 2003Applicant: Bristol-Myers Squibb CompanyInventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, David Bertil Frennesson, Mikael Mahler, Kurt Zimmermann