The Polycyclo Ring System Has At Least Six Cyclos, And Has Either A Ring Carbon That Is Shared By Three Of The Cyclos Or Has A Ring Chalcogen Patents (Class 548/417)
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Patent number: 6630500Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.Type: GrantFiled: August 22, 2001Date of Patent: October 7, 2003Assignee: Cephalon, Inc.Inventors: Diane E. Gingrich, Robert L. Hudkins
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Patent number: 6610727Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-1 activity and are useful in inhibiting the proliferation of tumor cells.Type: GrantFiled: September 27, 2001Date of Patent: August 26, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, David Bertil Frennesson, Mikael Mahler, Kurt Zimmermann
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Patent number: 6583168Abstract: Sulfonated diarylrhodamine compounds are useful as fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides. The compounds find particular application in the area of fluorescent nucleic acid analysis, e.g., automated DNA sequencing and fragment analysis, detection of probe hybridization in hybridization arrays, detection of nucleic acid amplification products, and the like.Type: GrantFiled: November 28, 2000Date of Patent: June 24, 2003Assignee: Applera CorporationInventors: Steven M. Menchen, Scott C. Benson, Joe Y. L. Lam, Weiguo Zhen, Daqing Sun, Barnett B. Rosenblum, Shaheer H. Khan, Meng Taing
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Patent number: 6566071Abstract: Dibenzorhodamine compounds having the structure: are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure: including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.Type: GrantFiled: October 2, 2001Date of Patent: May 20, 2003Assignee: Applera CorporationInventors: Scott C. Benson, Joe Y. L. Lam, Steven Michael Menchen
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Patent number: 6448412Abstract: The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.Type: GrantFiled: October 30, 2000Date of Patent: September 10, 2002Assignee: Sphere Biosystems, Inc.Inventors: Randall B. Murphy, Stephen R. Wilson, Quing Lu
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Publication number: 20020111375Abstract: The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.Type: ApplicationFiled: September 27, 2001Publication date: August 15, 2002Inventors: Mark G. Saulnier, Edward H. Ruediger, Neelakantan Balasubramanian, David Bertil Frennesson, Mikael Mahler, Kurt Zimmermann
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Patent number: 6426023Abstract: The invention relates to novel benzopyran-type compounds having an aromatic heterocycle annelated in position 7,8 and a carbocycle annelated in position 5,6. These compounds have the formula (I) given below: These compounds (I) have interesting photochromic properties. The invention also relates to their preparation, to their applications as photochromes, as well as to the compositions and (co)polymer matrices containing them.Type: GrantFiled: June 8, 2000Date of Patent: July 30, 2002Assignee: Corning, S.A.Inventors: Olivier Breyne, You-Ping Chan, Patrick Jean
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Patent number: 6407260Abstract: The invention relates to novel indole compounds, to their use as direct dyes in compositions intended for dyeing keratin materials and for example compositions intended for dyeing human keratin fibers and including the hair, and in cosmetic compositions intended for making up the skin, the nails and the lips, to the dye compositions or make-up compositions comprising them and to the direct dyeing process using them, and processes of manufacturing said novel indole compounds.Type: GrantFiled: September 20, 2000Date of Patent: June 18, 2002Assignee: L'Oréal S.A.Inventors: Nicole Bonaventure, Patrick Gilard, Gilles Barre, Michel Dubois
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Patent number: 6399786Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: GrantFiled: July 9, 2001Date of Patent: June 4, 2002Assignee: Merck & Co., Inc.Inventors: Steven L. Colletti, Michael H. Fisher, Peter T. Meinke, Matthew J. Wyvratt
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Patent number: 6399785Abstract: The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.Type: GrantFiled: October 30, 2000Date of Patent: June 4, 2002Assignee: C-Sixty, Inc.Inventors: Randall B. Murphy, Stephen R. Wilson, Quing Lu
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Publication number: 20020045653Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: ApplicationFiled: July 9, 2001Publication date: April 18, 2002Inventors: Thomas Shih, Steven L. Colletti, Michael H. Fisher, Peter T. Meinke, Dong Ok, Prasun K. Chakravarty, Matthew J. Wyvratt
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Publication number: 20020045598Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: ApplicationFiled: July 9, 2001Publication date: April 18, 2002Inventors: Steven L. Colletti, Michael H. Fisher, Peter T. Meinke, Matthew J. Wyvratt
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Patent number: 6323039Abstract: The invention provides compositions and methods for monitoring subcellular compartments such as organelles by energy transfer techniques that do not require specific intermolecular affinity binding events between energy transfer donor and energy transfer acceptor molecules. Provided are methods for assaying cellular membrane potential, including mitochondrial membrane potential, by energy transfer methodologies including fluorescence resonance energy transfer (FRET). Diagnostic and drug screening assays are also provided.Type: GrantFiled: June 22, 1999Date of Patent: November 27, 2001Assignee: MitokorInventors: James A. Dykens, Gönül Veliçelebi, Soumitra S. Ghosh
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Patent number: 6221894Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: GrantFiled: March 17, 1999Date of Patent: April 24, 2001Assignee: Merck & Co., Inc.Inventors: Peter T. Meinke, Thomas L. Shih, Michael H. Fisher
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Patent number: 6214865Abstract: The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the cell to the agents.Type: GrantFiled: June 16, 1999Date of Patent: April 10, 2001Assignee: Eisai Co., Ltd.Inventors: Bruce A. Littlefield, Monica H. Palme, Boris M. Seletsky, Murray J. Towle, Melvin J. Yu, Wanjun Zheng
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Patent number: 6162926Abstract: The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C.sub.n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by .sup.3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.Type: GrantFiled: November 13, 1997Date of Patent: December 19, 2000Assignee: Sphere Biosystems, Inc.Inventors: Randall B. Murphy, Stephen R. Wilson, Quing Lu
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Patent number: 6143732Abstract: The Sesquiterpene derivatives are useful as antivirus agents, which are shown by the formula: ##STR1## wherein R.sup.1 is hydrogen or halogen; and R.sup.2 is hydrogen, halogen, --OR.sup.7 (wherein R.sup.7 is hydrogen etc.) or --NHR.sup.8 (wherein R.sup.8 is hydrogen etc.) etc., or R.sup.1 and R.sup.2 taken together may form oxo or .dbd.NR.sup.9 (wherein R.sup.9 is hydroxy etc.);R.sup.3 is hydrogen or halogen; R.sup.4 is hydrogen, halogen, --OR.sup.10 (wherein R.sup.10 is hydrogen etc.), or --NHR.sup.11 (wherein R.sup.11 is hydrogen etc.), or R.sup.3 and R.sup.4 taken together may form oxo or .dbd.NR.sup.12 (wherein R.sup.12 is hydroxy etc.) or R.sup.2 and R.sup.4 taken together may form an unsaturated bond or --O--;A is .dbd.NR.sup.5 (wherein R.sup.5 is hydrogen, lower alkyl etc.)R.sup.6 is hydrogen, cyano etc.,X is hydrogen, cyano etc.,Y.sup.1 and Y.sup.2 are both hydrogens, or taken together may form oxo;Z.sup.1 and Z.sup.2 are both hydrogens, or taken together may form oxo, or Z.sup.1 is hydrogen and Z.Type: GrantFiled: September 20, 1999Date of Patent: November 7, 2000Assignee: Shionogi & Co., Ltd.Inventors: Kenichi Sugita, Naohiko Hattori
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Patent number: 6093834Abstract: Preparation of perylene-3,4-dicarboxylic acid anhydrides of the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 can each be independently of one another hydrogen, halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.4 cycloalkyl, C.sub.1 -C.sub.20 alkoxy, phenyl, phenyloxy or phenylthio, where phenyl can in each case be mono- or polysubstituted by halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl and/or C.sub.1 -C.sub.20 alkoxy; --NR.sup.5.sub.2 or --OR.sup.5, wherein R.sup.5 is hydrogen or C.sub.1 -C.sub.20 alkyl, or one of the pairs R.sup.1 /R.sup.2 and R.sup.3 /R.sup.4 each in 6,7- or 1,12-position is a bridge having the bridge atoms or bridge atom groups --O--, --S--, S.dbd.O, SO.sub.2 or --NR.sup.6, wherein R.sup.6 is hydrogen, C.sub.1 -C.sub.20 alkyl or C.sub.3 -C.sub.14 cycloalkyl, by treating a perylene-3,4-dicarboximide of formula II ##STR2## (a) in a first step with a base and, (b) in a second step, reacting the resultant anion with an alkylation agent R.sup.Type: GrantFiled: January 26, 1999Date of Patent: July 25, 2000Assignee: Ciba Specialty Chemicals CorporationInventor: Leonhard Feiler
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Patent number: 5962499Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: GrantFiled: March 23, 1998Date of Patent: October 5, 1999Assignee: Merck & Co., Inc.Inventors: Peter T. Meinke, Thomas Shih, Michael H. Fisher
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Patent number: 5945317Abstract: Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.Type: GrantFiled: September 21, 1998Date of Patent: August 31, 1999Assignee: Merck & Co., Inc.Inventors: Kevin M. Byrne, Arlene M. Dahl, Anne Dombrowski, Joyce A. Greene, John G. Ondeyka, Dan A. Ostlind, Sheo Bux Singh, Diane M. Vesey
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Patent number: 5900490Abstract: Preparation of perylene-3,4-dicarboxylic acid anhydrides of the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 can each be independently of one another hydrogen, halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl, C.sub.1 -C.sub.20 alkoxy, phenyl, phenyloxy or phenylthio, where phenyl can in each case be mono- or polysubstituted by halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl and/or C.sub.1 -C.sub.20 alkoxy; --NR.sup.5.sub.2 or --OR.sup.5, wherein R.sup.5 is hydrogen or C.sub.1 -C.sub.20 alkyl, or one of the pairs R.sup.1 /R.sup.2 and R.sup.3 /R.sup.4 each in 6,7- or 1,12-position is a bridge having the bridge atoms or bridge atom groups --O--, --S--, S.dbd.O, SO.sub.2 or --NR.sup.6, wherein R.sup.6 is hydrogen, C.sub.1 -C.sub.20 alkyl or C.sub.3 -C.sub.14 cycloalkyl, by treating a perylene-3,4-dicarboximide of formula II ##STR2## (a) in a first step with a base and, (b) in a second step, reacting the resultant anion with an alkylation agent R.sup.Type: GrantFiled: January 14, 1998Date of Patent: May 4, 1999Assignee: Ciba Specialty Chemicals CorporationInventor: Leonhard Feiler
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Patent number: 5883114Abstract: The present invention is concerned with the use of indolocarbazole imides of the general formula (I): ##STR1## for the preparation of pharmaceutical compositions for the treatment and/or prevention of cancer, virus diseases (for example HIV infections), heart and blood vessel diseases (for example high blood pressure, thromboses, heart rhythm disturbances and atheroscleroses), bronchopulmonary diseases, degenerative diseases of the central nervous system (for example Alzheimer's disease), inflammatory diseases (for example rheumatism and arthritis), diseases of the immune system (for example allergies), as well as psoriasis and for use as immune suppressives; as well as new compounds of general formula (I).Type: GrantFiled: February 15, 1995Date of Patent: March 16, 1999Assignee: Goedecke AktiengesellschaftInventors: Jurgen Kleinschroth, Christoph Schachtele, Johannes Hartenstein, Claus Rudolph, Hubert Barth, Julian Aranda, Hans Jurgen Betche
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Patent number: 5834260Abstract: Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.Type: GrantFiled: August 20, 1997Date of Patent: November 10, 1998Assignee: Merck & Co., Inc.Inventors: Kevin M. Byrne, Arlene M. Dahl, Anne Dombrowski, Joyce A. Greene, John G. Ondeyka, Dan A. Ostlind, Sheo Bux Singh, Diane M. Vesey
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Patent number: 5808060Abstract: Disclosed are biologically active, non-indole-containing compounds referred to as fused isoindolones, which are represented by the following general formula: ##STR1## The fused indolones can be obtained by complete chemical synthesis. Methods for making and using the fused isoindolones are disclosed.Type: GrantFiled: December 9, 1996Date of Patent: September 15, 1998Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Neil W. Johnson
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Patent number: 5801190Abstract: Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo?2,3-c!carbazole-6-ones. These molecules are represented by the following general formulae: ##STR1## Methods for making and using the fused pyrrolo?2,3-c!carbazole-6-ones are also disclosed.Type: GrantFiled: March 28, 1997Date of Patent: September 1, 1998Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, James L. Diebold, Ernest Knight, Jr.
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Patent number: 5723072Abstract: Described are novel photochromic heterocyclic fused indenonaphthopyran compounds having a substituted or unsubstituted heterocyclic ring fused to the g, h, i, n, o or p side of the indenonaphthopyran. These compounds may be represented by either of the following graphic formulae: ##STR1## Also described are polymeric organic host materials that contain or that are coated with such compounds.Type: GrantFiled: March 18, 1997Date of Patent: March 3, 1998Assignee: PPG Industries, Inc.Inventor: Anil Kumar
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Patent number: 5705511Abstract: Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional pharmacological activities including effect on the function and/or survival of trophic factor responsive cells; inhibition of enzymatic activity; inhibition of inflammation-associated responses; inhibition of cell growth associated with hyperproliferative states; and inhibition of developmentally programmed motoneuron death. The disclosed compounds are represented by the following general formula: ##STR1## Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.Type: GrantFiled: September 11, 1995Date of Patent: January 6, 1998Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Ernest Knight, Jr.
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Patent number: 5698141Abstract: Described are novel photochromic heterocyclic fused indenonaphthopyran compounds having a substituted or unsubstituted heterocyclic ring fused to the g, h, i, n, o or p side of the indenonaphthopyran. These compounds may be represented by either of the following graphic formulae: ##STR1## Also described are polymeric organic host materials that contain or that are coated with such compounds.Type: GrantFiled: January 16, 1997Date of Patent: December 16, 1997Assignee: PPG Industries, Inc.Inventor: Anil Kumar
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Patent number: 5651923Abstract: Described are novel reversible photochromic 2H-naphtho[1,2-b]pyran compounds, examples of which are compounds fused on the naphtho-portion of the naphthopyran ring with an indeno group or certain heterocyclic substituents. Certain substituents are also present at the 2 and 5 positions and sometimes at the 6 position of the naphthopyran ring. Also described are organic host materials that contain or that are coated with such compounds. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., spiro(indoline) type compounds, are also described.Type: GrantFiled: December 12, 1995Date of Patent: July 29, 1997Assignee: Transitions Optical, Inc.Inventors: Anil Kumar, David B. Knowles, Barry Van Gemert
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Patent number: 5629304Abstract: The present invention provides a method of treating thrombocytopenia, which comprises administering to a patient suffering from thrombocytopenia, an effective amount of an indolocarbazole derivative represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group or a tetrahydropyranyl group; R.sup.2A and R.sup.3A, which may be the same or different, each represent a hydrogen atom, a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a substituted or unsubstituted aralkyl group or a monosaccharide residue where a hydroxyl group at the anomer position is removed; R.sup.4A and R.sup.5A, which may be the same or different, each represent a hydrogen atom, a formyl group, a hydroxyl group or a halogen atom; W.sup.A1 and W.sup.A2 represent hydrogen atoms or are combined together to form an oxygen atom; and X.sup.A1 and X.sup.Type: GrantFiled: April 25, 1996Date of Patent: May 13, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Chikara Murakata, Fumihiko Kanai, Yutaka Saitoh, Yukimasa Shiotsu, Takako Shiraki, Tatsuya Tamaoki, Shiro Akinaga, Masami Okabe
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Patent number: 5616724Abstract: Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo[2,3-c]carbazole-6-ones. These molecules are represented by the following general formulae: ##STR1## Methods for making and using the fused pyrrolo[2,3-c]carbazole-6-ones are also disclosed.Type: GrantFiled: February 21, 1996Date of Patent: April 1, 1997Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, James L. Diebold, Ernest Knight, Jr.
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Patent number: 5614546Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.Type: GrantFiled: December 20, 1994Date of Patent: March 25, 1997Assignee: Merck & Co., Inc.Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
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Patent number: 5599957Abstract: An optically active manganese complex of the formula I.sub.a, I.sub.b, I.sub.c and I.sub.d ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen atom, C.sub.1 -.sub.4 alkyl group, phenyl group which may be substituted by a halogen atom, C.sub.1 -.sub.4 alkyl group, C.sub.1 -.sub.4 alkoxyl group, cyano group or nitro group; and any two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 together form a C.sub.4 -.sub.8 ring, X.sup.- represents a counter anion which may form a salt, Y represents hydrogen atom, halogen atom, C.sub.1 -.sub.4 alkyl group, C.sub.1 -.sub.4 alkoxyl group, nitro group or cyano group, R represents hydrogen atom, C.sub.1 -.sub.4 alkyl group, phenyl group which may be substituted by halogen atom, C.sub.1 -.sub.4 alkyl group or C.sub.1 -.sub.4 alkoxyl group, or substituted silyl group and a process for producing epoxy compounds using the complex as a catalyst.Type: GrantFiled: May 30, 1995Date of Patent: February 4, 1997Assignee: Nissan Chemical Industries, Ltd.Inventors: Tsutomu Katsuki, Ryo Irie, Hidehiko Sasaki
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Patent number: 5591855Abstract: Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional activities. The disclosed compounds are represented by the following general formula: ##STR1## Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.Type: GrantFiled: April 24, 1995Date of Patent: January 7, 1997Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Ernest Knight, Jr.
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Patent number: 5541208Abstract: The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).Type: GrantFiled: January 24, 1994Date of Patent: July 30, 1996Assignee: Merck & Co., Inc.Inventors: Maria L. Garcia, Robert A. Giacobbe, Otto D. Hensens, Seok H. Lee, Owen B. McManus, Deborah L. Zink
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Patent number: 5505743Abstract: Vat dyes obtainable bya) halogenation of dibenzanthrone with bromine in the presence of chlorosulfonic acid and of a halogenation catalyst to a bromine content from 26 to 32% by weight and a chlorine content from 1 to 5% by weight, andb) condensation of the isolated halogenation product with 1-aminoanthraquinone in a molar ratio from 1:2 to 1:2.5 in the presence of an inert solvent, the concentration of halogenated dibenzanthrone and 1-aminoanthraquinone together being at least 200 g/l of solventare useful for dyeing or printing cellulose-containing textile material.Type: GrantFiled: October 21, 1994Date of Patent: April 9, 1996Assignee: BASF AktiengesellschaftInventors: Matthias Niedenbrueck, Manfred Patsch, Michael Schmitt
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Patent number: 5492902Abstract: Shearinines A, B and C, and 21-Isopentenylpaxilline are ascostromatal metabolites of the fungus Eupenicillium shearii. These indole alkaloid compounds are effective for controlling Coleopteran and Lepidopteran insects and the fall armyworm, Spodoptera frugiperda.Type: GrantFiled: December 2, 1994Date of Patent: February 20, 1996Assignees: The United States of America as represented by the Secretary of Agriculture, University of Iowa Research Foundation, Biotechnology Research & Development CorporationInventors: Gilbert N. Belofsky, James B. Gloer, Donald T. Wicklow, Patrick F. Dowd
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Patent number: 5475110Abstract: Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional activities. The disclosed compounds are represented by the following general formula: ##STR1## Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.Type: GrantFiled: October 14, 1994Date of Patent: December 12, 1995Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, Ernest Knight, Jr.
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Patent number: 5468874Abstract: A novel benzothiophene/indole-substituted maleimide derivative, a photochromic material and an optical recording material using the same. The benzothiophene/indole-substituted maleimide derivative is represented by the following formula (1): ##STR1## or the following formula (2): ##STR2## wherein R is a substituted or an unsubstituted monovalent hydrocarbon group, R.sup.1 and R.sup.2 are a hydrogen atom, an alkyl group, an alkylthio group or an alkoxy group under the condition where at least either one of them is an alkylthio group or an alkoxy group, R.sup.3 is an alkyl group or an acyl group, and rings A and B may not be substituted or may be substituted with an alkyl group, an alkoxy group or a halogen atom, respectively.Type: GrantFiled: March 25, 1994Date of Patent: November 21, 1995Assignee: Mita Industrial Co., Ltd.Inventors: Fumio Sugai, Masahiro Irie
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Patent number: 5468872Abstract: Functional K-252a derivatives are used to enhance trk phosphorylation and to potentiate the activity of neurotrophin-3 (NT-3). These compounds can be used to treat neurological disorders, alone or in combination with NT-3.Type: GrantFiled: September 16, 1993Date of Patent: November 21, 1995Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Marcie A. Glicksman, David P. Rotella, Nicola Neff, Chikara Murakata
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Patent number: 5459268Abstract: The dyes of the present invention are fluorescent substituted 3',6'-diaminoxanthenes and their reduced analogs 3',6'-diaminodihydroxanthenes, which are oxidized to the fluorescent form of the dye in situ. In their oxidized form, the dyes selectively localize within mitochondria. The dyes of the present invention include an alkylating group that is covalently attached that allows their retention in mitochondria even after cell death, fixation, and permeabilization.Type: GrantFiled: October 25, 1993Date of Patent: October 17, 1995Assignee: Molecular Probes, Inc.Inventors: Richard P. Haugland, Mohammad N. Malekzadeh, Yu-zhong Zhang
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Patent number: 5457119Abstract: New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.Type: GrantFiled: July 8, 1994Date of Patent: October 10, 1995Assignee: Eli Lilly and CompanyInventors: Roseanne Bonjouklian, Richard E. Moore, Gregory M. L. Patterson, Tim A. Smitka
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Patent number: 5438050Abstract: New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.Type: GrantFiled: January 21, 1994Date of Patent: August 1, 1995Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Johannes Hartenstein, Hubert Barth, Christoph Schachtele, Claus Rudolph, Gunter Weinheimer, Hartmut Osswald
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Patent number: 5420314Abstract: An optically active manganese complex of the formula I or I': ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 independently represent hydrogen atom, C.sub.1 -C.sub.4 alkyl group, phenyl group which may be substituted by a halogen atom, C.sub.1 -C.sub.4 alkyl group, C.sub.1 -C.sub.4 alkoxyl group, cyano group or nitro group; and any two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 together form the C.sub.4 -C.sub.8 ring, X.sup.- represents a counter anion which may form a salt, Y represents hydrogen atom, halogen atom, C.sub.1 -C.sub.4 alkyl group, C.sub.1 -C.sub.4 alkoxyl group, nitro group or cyano group, R represents hydrogen atom, C.sub.1 -C.sub.4 alkyl group, phenyl group which may be substituted by halogen atom, C.sub.1 -C.sub.4 alkyl group or C.sub.1 -C.sub.4 alkoxyl group, or substituted silyl group and a process for producing epoxy compounds using the complex as a catalyst.Type: GrantFiled: March 14, 1994Date of Patent: May 30, 1995Assignee: Nissan Chemical Industries, Ltd.Inventors: Tsutomu Katsuki, Ryo Irie, Hidehiko Sasaki
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Patent number: 5399582Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.Type: GrantFiled: November 1, 1993Date of Patent: March 21, 1995Assignee: Merck & Co., Inc.Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
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Patent number: 5300495Abstract: Sulpinine C, secopenitrem B and 10-oxo-11,33-dihydropenitrem B indole compounds have been isolated from the sclerotia of the fungi Aspergillus sulphureus. Aflatrem B has been isolated from the sclerotia of the fungi Aspergillus flavus, and 14-hydroxypaspalinine and 14-(N,N-dimethylvalyloxy)paspalinine have been isolated from the sclerotia of the fungi Aspergillus nomius. The indole compounds are effective for controlling Coleopteran and Lepidopteran insects.Type: GrantFiled: January 22, 1993Date of Patent: April 5, 1994Assignees: The United States of America, as represented by the Secretary of Agriculture, University of Iowa Research Foundation, Biotechnology Research & Development CorporationInventors: Jodi A. Laakso, Patrick F. Dowd, James B. Gloer, Donald T. Wicklow
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Patent number: 5264538Abstract: Cyclic poly(aryl ether) oligomers and mixtures thereof, and methods for the preparation thereof in a highly dilute reaction medium under reaction conditions favorable for ring closure at low degrees of polymerization. These oligomers are represented by the general formula ##STR1## where each Y is divalent oxygen or divalent sulfur, each Ar is an aromatic diradical which comprises one or more C.sub.6 to C.sub.20 arylene groups and has at least one electron withdrawing group attached to an aromatic ring, and n is an integer from 1 to about 20 with the proviso that for integer values of n equal to 1 or 2 all linkages between independent aromatic rings comprise at least one atom.Type: GrantFiled: June 27, 1990Date of Patent: November 23, 1993Assignee: The Dow Chemical CompanyInventors: Michael J. Mullins, Edmund P. Woo, Kimberly E. Balon, Daniel J. Murray, Cheng-Cheng C. Chen
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Patent number: 5256685Abstract: Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.Type: GrantFiled: March 26, 1992Date of Patent: October 26, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Yutaka Kanda, Motomichi Kono, Masaji Kasai, Tadashi Ashizawa, Katsushige Gomi
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Patent number: 5242551Abstract: A method of isomerizing an isoimide to an n-imide is described wherein an electron is supplied to the isoimide which induces the isomerization and wherein the isomerization is catalytic to the electron which remains available to initiate further isomerization. A polyimide is deposited onto a conductive substrate by providing a composition containing a polyisoimide and an electrolyte providing the substrate and a counter electrode in the composition, and providing a bias between the substrate and counter electrode to thereby supply an electron to the polyisoimide which isomerizes to deposit the insoluble polyimide on the substrate.Type: GrantFiled: October 3, 1991Date of Patent: September 7, 1993Assignee: International Business Machines CorporationInventors: Ernest R. Frank, Terrence R. O'Toole, Alfred Viehbeck
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Patent number: 5227396Abstract: Sulpinine C, secopenitrem B and 10-oxo-11,33-dihydropenitrem B indole compounds have been isolated from the sclerotia of the fungi Aspergillus sulphureus. Aflatrem B has been isolated from the sclerotia of the fungi Aspergillus flavus, and 14-hydroxypaspalinine and 14-(N,N-dimethylvalyloxy)paspalinine have been isolated from the sclerotia of the fungi Aspergillus nomius. The indole compounds are effective for controlling Coleopteran and Lepidopteran insects.Type: GrantFiled: April 29, 1992Date of Patent: July 13, 1993Assignees: The United States of America as represented by the Secretary of Agriculture, University of Iowa Research Foundation, Biotechnology Research & Development CorporationInventors: Jodi A. Laakso, Mark R. TePaske, Patrick F. Dowd, James B. Gloer, Donald T. Wicklow, Gail M. Staub