Plural Chalcogens Bonded Directly To Ring Carbons Of The Five-membered Hetero Ring (e.g., Cyclic Imides, Etc.) Patents (Class 548/435)
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Patent number: 11492355Abstract: The invention relates to a crosslinking compound of formula (I) In particular, the present invention relates to a liquid composition comprising a monomer, a (meth)acrylic polymer and at least one crosslinking compound of formula (I). This liquid composition may be used in the form of a syrup and in particular in the form of a syrup for impregnating fibers or fibrous material. The invention also relates to a pseudo-thermoplastic material obtained after polymerization of the liquid composition being at least partially crosslinked. The invention also relates to a process for manufacturing such a liquid composition. The invention also relates to a process for impregnating a long-fiber fibrous substrate with said liquid composition. The invention also relates to a fibrous substrate impregnated with said liquid composition which is useful for manufacturing composite parts.Type: GrantFiled: March 27, 2018Date of Patent: November 8, 2022Assignee: ARKEMA FRANCEInventors: Jean-Charles Fontanier, Jean-Francois Gerard, Pierre Gerard, Frederic Lortie, Jean-Pierre Pascault
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Patent number: 10831100Abstract: A photoacid generator compound having formula (I): wherein, in formula (I), groups and variables are the same as described in the specification.Type: GrantFiled: November 20, 2017Date of Patent: November 10, 2020Assignee: ROHM AND HAAS ELECTRONIC MATERIALS, LLCInventors: Emad Aqad, James W. Thackeray
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Patent number: 10042252Abstract: The present disclosure provides a method for lithography patterning in accordance with some embodiments. The method includes forming a photoresist layer over a substrate, wherein the photoresist layer includes a polymer, a sensitizer, and a photo-acid generator (PAG), wherein the PAG includes a first phenyl ring and a second phenyl ring both chemically bonded to a sulfur, the first and second phenyl rings being further chemically bonded with enhanced sensitivity; performing an exposing process to the photoresist layer; and developing the photoresist layer, thereby forming a patterned photoresist layer.Type: GrantFiled: January 23, 2017Date of Patent: August 7, 2018Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.Inventors: Yen-Hao Chen, Wei-Han Lai, Chien-Wei Wang, Chin-Hsiang Lin
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Patent number: 9023340Abstract: Methods and small molecule compounds for stem cell differentiation and treatment of animals with diseases are provided. One example of a class of compounds that may be used is represented by the compound of Formula I and II: or a pharmaceutically acceptable salt or solvate thereof, wherein A, X, Q, R1, R2, R3, R4 are as described herein.Type: GrantFiled: July 2, 2012Date of Patent: May 5, 2015Assignee: ChemRegen, Inc.Inventors: John Cashman, Marion Lanier, Mark Mercola, Dennis Schade, Erik Willems
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Patent number: 8883888Abstract: There are provided a novel diarylamine compound represented by the following formula (I), (II) or (III), which has at least one signal attributable to the hydrogen of the N—H moiety at 8.30 ppm to 9.00 ppm when a deuterated dimethyl sulfoxide solution of the diarylamine compound is analyzed by 1H-NMR; and an aging inhibitor, a polymer composition, a crosslinked rubber product and a molded article thereof, and a method of producing a diarylamine compound. In the formulas, A1 to A6 each represent an aromatic group which may have a substituent; A represents an aromatic group or a cyclic aliphatic group, which may both have a substituent; L represents 1 or 2; and n represents 0 or 1.Type: GrantFiled: June 30, 2010Date of Patent: November 11, 2014Assignee: Zeon CorporationInventors: Kei Sakamoto, Tomonori Ogawa, Satoshi Kiriki, Masanobu Shinohara, Yasushi Nakano
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Publication number: 20140179922Abstract: The present invention relates to a process for the preparation of Lurasidone or a pharmaceutically acceptable salt thereof, a compound useful for the treatment of schizophrenia and bipolar disorder. The present invention further relates to processes for the preparation of Lurasidone intermediates, and to certain novel intermediates obtained by such processes.Type: ApplicationFiled: June 13, 2012Publication date: June 26, 2014Applicant: MAPI PHARMA LTD.Inventors: Ehud Marom, Michael Mizhiritskii, Susanna Tchilibon, Shai Rubnov
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Publication number: 20140142279Abstract: A new method based on the synthesis and use of novel N and C protecting agents. The new N-protecting agent, here referred to as V-Phenol, generates V-protected amino acids and can be successfully applied to all conventional peptide bond formations including active esters, N,N?-dicyclohexylcarbodiimide (DCC) or related dehydrating agents mixed anhydride methods, PC13 and related agents. The new C-protecting agent, here referred to as HONE, can be successfully applied to peptide synthesis as an active ester not only in combination with V-protected amino acids but also with other N-protecting agents such as Cbz, Boc, Fmoc, etc.Type: ApplicationFiled: September 12, 2013Publication date: May 22, 2014Inventors: Iraj Lalezari, Parviz Lalezari
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Publication number: 20140117280Abstract: An oxygen absorber is provided that contains at least one of compounds each having a particular structure, and the oxygen absorber exhibits an oxygen absorbing capability without a metal contained, and is suitable for removing oxygen inside a packaging material packaging foods or the like.Type: ApplicationFiled: May 16, 2012Publication date: May 1, 2014Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Kentaro Ishii, Ryoji Otaki, Takafumi Oda, Shota Arakawa
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Publication number: 20140080984Abstract: The present invention relates to a kind of novel carbene ligands and ruthenium catalysts, which is highly active and selective for ROMP and RCM reactions, respectively. It discloses the significant electronic and steric effect of different substituted carbene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes; some of novel ruthenium complexes in the invention can be broadly used as catalysts highly effectively and selective for ROMP and RCM reactions. The invention also relates to preparation of new ruthenium catalysts and the uses in metathesis. Moreover, the invention also provides effective methods of making various functional polymers by ROMP reaction in the presence of new ruthenium catalysts.Type: ApplicationFiled: November 21, 2013Publication date: March 20, 2014Applicant: ZANNA SCITECH CO., LTD.Inventor: Zheng-Yun James ZHAN
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Patent number: 8541599Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.Type: GrantFiled: March 7, 2012Date of Patent: September 24, 2013Assignee: Isis Pharmaceuticals, Inc.Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju K. Kumar
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Publication number: 20130177535Abstract: Methods and small molecule compounds for stem cell differentiation and treatment of animals with diseases are provided. One example of a class of compounds that may be used is represented by the compound of Formula I and II: or a pharmaceutically acceptable salt or solvate thereof, wherein A, X, Q, R1, R2, R3, R4 are as described herein.Type: ApplicationFiled: July 2, 2012Publication date: July 11, 2013Inventors: John Cashman, Marion Lanier, Mark Mercola, Dennis Schade, Erik Willems
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Patent number: 8445491Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.Type: GrantFiled: May 27, 2009Date of Patent: May 21, 2013Assignee: The Board of Regents of the University of Texas SystemInventors: Lawrence Lum, Michael G. Roth, Baozhi Chen, Chuo Chen, Michael E. Dodge, Wei Tang
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Publication number: 20120165547Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.Type: ApplicationFiled: March 7, 2012Publication date: June 28, 2012Applicant: ISIS PHARMACEUTICALS, INC.Inventors: VASULINGA RAVIKUMAR, MUTHIAH MANOHARAN, ANDREI P. GUZAEV, ZHIWEI WANG, RAJU KRISHNA KUMAR
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Publication number: 20120165546Abstract: The present disclosure provides a process for the mono-reduction of one or more imide moieties in a compound comprising contacting the compound with hydrogen gas and a catalyst comprising a transition metal hydride in the presence of a base, under conditions for the mono-reduction of the one or more imide moieties to form a compound comprising one or more hydroxy amides.Type: ApplicationFiled: June 17, 2010Publication date: June 28, 2012Inventors: Steven H. Bergens, Satoshi Takebayashi
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Publication number: 20120146264Abstract: A resin composition for laser engraving is provided that includes a low molecular weight compound containing at least one type of polymerizable group selected from the group consisting of an ethylenically unsaturated group, an epoxy group, an oxetanyl group, a hydrolyzable silyl group, and a silanol group and further containing a sulfonamide group, a low molecular weight compound containing a residue selected from the group consisting of a maleimide group, a succinimide group, and a phthalimide group, or a polymer compound containing a constituent unit derived from a compound containing a maleimide group or a constituent unit containing a sulfonamide group.Type: ApplicationFiled: December 9, 2011Publication date: June 14, 2012Applicant: FUJIFILM CORPORATIONInventor: Takashi KAWASHIMA
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Publication number: 20120101196Abstract: There are provided a novel diarylamine compound represented by the following formula (I), (II) or (III), which has at least one signal attributable to the hydrogen of the N—H moiety at 8.30 ppm to 9.00 ppm when a deuterated dimethyl sulfoxide solution of the diarylamine compound is analyzed by 1H-NMR; and an aging inhibitor, a polymer composition, a crosslinked rubber product and a molded article thereof, and a method of producing a diarylamine compound. In the formulas, A1 to A6 each represent an aromatic group which may have a substituent; A represents an aromatic group or a cyclic aliphatic group, which may both have a substituent; L represents 1 or 2; and n represents 0 or 1.Type: ApplicationFiled: June 30, 2010Publication date: April 26, 2012Inventors: Kei Sakamoto, Tomonori Ogawa, Satoshi Kiriki, Masanobu Shinohara, Yasushi Nakano
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Publication number: 20120041137Abstract: The present invention provides a new class of thermosetting ring-opening metathesis polymerization materials based on norbornene and oxanorbornene dicarboximide moieties containing at least one acetal ester group linkage. The acetal ester group is degradable when subjected to heat or acidic aqueous hydrolysis. The polymerization materials can be used in reworkable thermosetting compositions. R1-Rs, X, and n are defined herein.Type: ApplicationFiled: March 2, 2010Publication date: February 16, 2012Applicant: ISP INVESTMENTS INC.Inventors: Osama M. Musa, Ezat Khosravi
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Publication number: 20110232944Abstract: A liquid crystalline thermoset oligomer or polymer including a structural unit of Chemical Formulae 1 and 2; and a functional group of Chemical Formula A,Type: ApplicationFiled: December 13, 2010Publication date: September 29, 2011Applicants: SAMSUNG ELECTRONICS CO., LTD., SAMSUNG ELECTRO-MECHANICS CO., LTD., SAMSUNG FINE CHEMICALS CO., LTD.Inventors: Jae-Jun LEE, Kalinina FEDOSYA, Myung-Sup JUNG
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Publication number: 20110136813Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.Type: ApplicationFiled: May 27, 2009Publication date: June 9, 2011Inventors: Lawrence Lum, Michael G. Roth, Baozhi Chen, Chuo Chen, Michael E. Dodge, Wei Tang
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Publication number: 20110112306Abstract: A fluorine-containing sulfonic acid salt or a compound having a fluorine-containing sulfonic acid group, either of which having a structure represented by the following general formula (1), is provided. Such a salt or compound can act as a suitable photo-acid generator, and can form a resist pattern having excellent sensitivity, resolution and mask-dependence. [In general formula (1), R represents a substituted or unsubstituted linear or branched monovalent hydrocarbon group having 1 to 30 carbon atoms, a substituted or unsubstituted monovalent hydrocarbon group having 3 to 30 carbon atoms and a cyclic or a partially cyclic structure, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, or a substituted or unsubstituted monovalent heterocyclic organic group having 4 to 30 carbon atoms.Type: ApplicationFiled: July 6, 2009Publication date: May 12, 2011Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Masashi Nagamori, Masaki Fujiwara, Kazunori Mori, Satoru Narizuka
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Patent number: 7880018Abstract: A novel epoxy compound represented by the following general formula (I), and a production process thereof, is provided: Y—(CH2)3—Si(OR1)nR23-n??(I) (wherein, Y is represented by any of the following formulas: wherein, R1 and R2 represent alkyl groups having 1 to 5 carbon atoms, n represents an integer of 1 to 3, R3 and R4 represent hydrogen atoms, alkyl groups having 1 to 6 carbon atoms or trialkylsilyl groups having 1 to 4 carbon atoms, R5 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a trialkylsilyl group having 1 to 4 carbon atoms, R6 to R12 represent hydrogen atoms, alkyl groups having 1 to 6 carbon atoms or trialkylsilyl groups having 1 to 4 carbon atoms, and R13 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a trialkylsilyl group having 1 to 4 carbon atoms or an aryl group).Type: GrantFiled: August 13, 2007Date of Patent: February 1, 2011Assignee: Showa Denko K.K.Inventors: Nobutoshi Sasaki, Toshio Fujita, Hiroshi Uchida
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Publication number: 20110009456Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.Type: ApplicationFiled: December 21, 2009Publication date: January 13, 2011Applicant: Siga Technologies Inc.Inventors: Robert Jordan, Thomas R. Bailey, Susan R. Rippin
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Publication number: 20100249276Abstract: The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions.Type: ApplicationFiled: June 15, 2010Publication date: September 30, 2010Applicant: DESIGNER MOLECULES, INC.Inventor: Stephen M. Dershem
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Patent number: 7785495Abstract: An activated carbon comprising a carbonized and activated compound represented by the formula (1): (wherein, R represents a hydrocarbon group having 1 to 12 carbon atoms, said hydrocarbon group may be optionally substituted with hydroxyl group, alkyl group, alkoxy group, aryl group, aryloxy group, sulfonyl group, halogen atoms, nitro group, thioalkyl group, cyano group, carboxyl group, amino group or amide group, R? represents hydrogen atom or methyl group, and n represents an integer of 4, 6, or 8).Type: GrantFiled: May 24, 2006Date of Patent: August 31, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Taketoshi Kikuchi, Tamon Itahashi
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Publication number: 20100204485Abstract: Polyacetylinic oligomers suitable for high-temperature polymer-matrix composites are provided. The polyacetylinic oligomers have the formula: D-A-D wherein D is an endcap including at least one crosslinking functionality; and A is backbone selected from the group consisting of imidesulfone; ether; ethersulfone; amide; imide; ester; estersulfone; etherimide; amideimide; oxazole; oxazole sulfone; thiazole; thiazole sulfone; imidazole; and imidazole sulfone. At least one ethynyl functional group, however, is incorporated into the backbone such that crosslinking is not only realized at the endcaps but also at the ethynyl groups within the backbone of the oligomer itself.Type: ApplicationFiled: October 20, 2009Publication date: August 12, 2010Inventors: Thomas K. Tsotsis, Norman R. Byrd
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Patent number: 7723399Abstract: The invention relates to novel N-substituted imides and polymerizable compositions comprising these N-substituted imides. The invention further relates to the use of N-substituted imides as polymerization initiators.Type: GrantFiled: October 31, 2005Date of Patent: May 25, 2010Assignee: Ciba Specialty Chemicals CorporationInventors: Peter Nesvadba, Johannes Benkhoff, Lucienne Bugnon, Karin Powell, Tunja Jung
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Patent number: 7667046Abstract: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.Type: GrantFiled: November 19, 2007Date of Patent: February 23, 2010Assignee: 3M Innovative Properties CompanyInventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. Moore, Rahul Shah
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Patent number: 7595349Abstract: Two new surfactant molecules are reported which contain thermally labile Diels-Alder adducts connecting the polar and non-polar sections of each molecule. The two surfactants possess identical non-polar dodecyl tail segments but exhibit different polar headgroups. The surfactants become soluble in water when anionic salts are formed through the deprotonation of the surfactant headgroups by the addition of potassium hydroxide. When either surfactant is exposed to temperature above about 60° C., the retro Diels-Alder reaction occurs, yielding hydrophilic and hydrophobic fragments or the aqueous solutions of the surfactants subsequently exhibit loss of all surface-active behavior.Type: GrantFiled: January 26, 2006Date of Patent: September 29, 2009Assignee: Sandia CorporationInventors: James R. McElhanon, Blake A. Simmons, Thomas Zifer, Gregory M. Jamison, Douglas A. Loy, Kamyar Rahimian, Timothy M. Long, David R. Wheeler, Chad L. Staiger
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Patent number: 7576119Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.Type: GrantFiled: January 11, 2007Date of Patent: August 18, 2009Assignee: Isis Pharmaceuticals, Inc.Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju K. Kumar
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Publication number: 20090182114Abstract: Disclosed is a novel tetracarboxylic acid compound having excellent characteristics such as high transparency, low dielectric property, low water absorption, low thermal expansion, solvent solubility and etching characteristics, while exhibiting high heat resistance at the same time. This tetracarboxylic acid compound is useful as a raw material monomer for producing a polyesterimide or a polyamideimide. Specifically disclosed is a tetracarboxylic acid compound represented by the general formula (1) or (2) below. In the formulae, A represents a divalent group; X1, X2 and X3 respectively represent a hydrogen atom or the like; R1, R2, R3 and R4 respectively represent a carboxyl group or an acid anhydride group; n represents 1 or 2; and ring B represents a cyclic group.Type: ApplicationFiled: November 14, 2006Publication date: July 16, 2009Inventors: Haruhiko Kusaka, Yuji Ohgomori, Masashi Yamanashi
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Patent number: 7517880Abstract: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.Type: GrantFiled: February 1, 2002Date of Patent: April 14, 2009Assignee: Bayer Pharmaceuticals CorporationInventors: Scott Miller, Martin Osterhout, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, David E. Gunn, Holia Hatoum-Mokdad, Marell Rodriguez, Robert Sibley, Ming Wang, Tiffany Turner, Catherine Brennan
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Publication number: 20090069521Abstract: A radiation-sensitive resin composition is provided which has high transparency to radiation, excelling in basic properties as a resist such as sensitivity, resolution, and pattern shape, and, in particular, a high resolution radiation-sensitive resin composition providing a wide DOF and excelling in LER. Also provided are a polymer which can be used in the composition and a novel compound useful for synthesizing the polymer. The novel compound is shown by the following formula (2), wherein R4 represents a methyl group, a trifluoromethyl group, or a hydrogen atom, at least one of the Rfs represents a fluorine atom or a linear or branched perfluoroalkyl group having 1 to 10 carbon atoms, A represents a divalent organic group or a single bond, G represents a divalent organic group having a fluorine atom or a single bond, Mm+ represents a metal ion or an onium cation, m represents an integer of 1 to 3, and p is an integer of 1 to 8.Type: ApplicationFiled: May 11, 2006Publication date: March 12, 2009Applicant: JSR CORPORATIONInventors: Tomoki Nagai, Eiji Yoneda, Takuma Ebata, Takanori Kawakami, Makoto Sugiura, Tsutomu Shimokawa, Makoto Shimizu
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Publication number: 20080249315Abstract: Multifunctional compounds having acylsulfonamide amine-reactive groups are described that can be used for the capture of amine containing materials.Type: ApplicationFiled: June 17, 2008Publication date: October 9, 2008Inventors: Karl E. Benson, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G.I. Moore, Rahul Shah
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Patent number: 7423155Abstract: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.Type: GrantFiled: November 12, 2004Date of Patent: September 9, 2008Assignee: 3M Innovative Properties CompanyInventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. I. Moore, Rahul R. Shah
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Publication number: 20080145907Abstract: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.Type: ApplicationFiled: November 19, 2007Publication date: June 19, 2008Inventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. Moore, Rahul R. Shah
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Publication number: 20080132600Abstract: The invention relates to novel N-substituted imides and polymerizable compositions comprising these N-substituted imides. The invention further relates to the use of N-substituted imides as polymerization initiators.Type: ApplicationFiled: October 31, 2005Publication date: June 5, 2008Inventors: Peter Nesvadba, Johannes Benkhoff, Lucienne Bugnon, Karin Powell, Tunja Jung
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Patent number: 7361767Abstract: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.Type: GrantFiled: November 14, 2003Date of Patent: April 22, 2008Assignee: 3M Innovative Properties CompanyInventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. Moore, Rahul Shah
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Patent number: 7351838Abstract: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.Type: GrantFiled: March 14, 2007Date of Patent: April 1, 2008Assignee: 3M Innovative Properties CompanyInventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. Moore, Rahul Shah
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Patent number: 7238814Abstract: The invention describes compositions and kits comprising 4-aza-4-(2-methyl-2-sulfanylpropyl) tricyclo(5.2.1.0<2,6>)dec-8-ene-3,5-dione; 4-aza-4-(2-methyl-2-(nitrosothio)propyl) tricyclo(5.2.1.0<2,6>)dec-8-ene-3,5-dione; 4-{1-methyl-1-((2,4,6-trimethoxyphenyl)methylthio)ethyl}-1,3-oxazolidin-2-one; 2-aAmino-3-methyl-3-((2,4,6-trimethoxyphenyl)methylthio)butan-1-ol; 4-(1-methyl-1-(nitrosothio)ethyl)-1,3-oxazolidin-2-one; or pharmaceutically acceptable salts thereof. The compositions of the invention can further comprise at least one penetration enhancer, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one vasoactive agent.Type: GrantFiled: February 20, 2004Date of Patent: July 3, 2007Assignee: NitroMed, Inc.Inventors: Przemyslaw A. Marek, Andzrej M. Trocha, Chia-En Lin, Ramani R. Ranatunge, Stewart K. Richardson
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Patent number: 7202264Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.Type: GrantFiled: November 15, 2004Date of Patent: April 10, 2007Assignee: Isis Pharmaceuticals, Inc.Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei P. Guzaev, Zhiwei Wang, Raju Krishna Kumar
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Patent number: 7115541Abstract: A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.Type: GrantFiled: November 8, 2001Date of Patent: October 3, 2006Assignee: Daicel Chemical Industries, Ltd.Inventors: Yasutaka Ishii, Tatsuya Nakano, Takahiro Iwahama, Naruhisa Hirai
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Patent number: 7074831Abstract: Compounds of formula (I) for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a daily dosage of from 0.005 mg/kg to 10 mg/kg body weight, in particular from 0.025 mg/kg to 2 mg/kg body weight.Type: GrantFiled: February 4, 2005Date of Patent: July 11, 2006Assignee: Active Biotech ABInventors: Stig Jönsson, Gunnar Andersson, Ulf Wellmar, Ingela Fritzson
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Patent number: 6963001Abstract: In accordance with the present invention, there are provided thermosetting resin compositions with a reduced propensity to shrink in volume upon cure and methods of use therefor. The compositions of the present invention include compounds having aromatic, rigid-rod like spacer groups between the crosslinkable moieties. As such, these compounds impart a degree of liquid crystal-like character to the thermosetting resin composition which results in lower shrinkage upon cure. This effect follows from the well-known expansion that occurs when liquid crystal-like materials pass from a nematic liquid crystal-like state to an isotropic state. Further provided by the present invention are low shrinkage die attach pastes and methods of use therefor.Type: GrantFiled: February 14, 2003Date of Patent: November 8, 2005Assignee: Henkel CorporationInventors: Stephen M. Dershem, Kang Yang, Puwei Liu
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Patent number: 6861441Abstract: The present invention relates to the use of an EP4 receptor ligand in the manufacture of a medicament for use in the treatment of neuropathic pain, colon cancer, migraine, and for increasing the latency of HIV infection.Type: GrantFiled: August 8, 2000Date of Patent: March 1, 2005Assignee: SmithKline Beecham CorporationInventors: Nicholas Maughan Clayton, Susanne Denise Collins, Steven Michael Foord, Gerard Martin Paul Giblin, Richard John Coles, Mark Bamford, Jennifer M Doughty, Richard Green
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Patent number: 6797841Abstract: Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.Type: GrantFiled: October 1, 2002Date of Patent: September 28, 2004Assignee: Albemarle CorporationInventors: John Gabriel Santobianco, Rajamani Nagarajan, August John Muller, Joseph Stanton Bowers, Jr.
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Patent number: 6762323Abstract: Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.Type: GrantFiled: October 1, 2002Date of Patent: July 13, 2004Assignee: Albemarle CorporationInventors: John Gabriel Santobianco, Rajamani Nagarajan, August John Muller, Joseph Stanton Bowers, Jr.
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Publication number: 20040087624Abstract: Compounds of formula (I) 1Type: ApplicationFiled: December 10, 2003Publication date: May 6, 2004Inventors: Gerard Martin Paul Giblin, Stephen Vernon Frye, Susan Roomans
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Patent number: 6576767Abstract: Process for the preparation of a condensation compound by reaction of at least one functional group of a first low-molecular weight compound having at least two functional groups, with at least one functional group of at least one further, second low-molecular weight compound having at least two functional groups, and which can be identical to the first or different from the first low-molecular weight compound, with obtainment of a condensation compound, characterized in that at least one of the functional groups involved in this reaction has been activated before the reaction by reaction with a compound of the following structure (I) where R′ is a halogen atom or a radical (I′) and where R1, R2, R1′ and R2′ are identical or different and are hydrogen, straight-chain or branched-chain alkyl, aryl, cycloalkyl, heterocyclic or aralkyl radicals having up to 30 C atoms, or either R1 and R2 or R1′ and R2′ or both R1 and R2 and R1′ and R2Type: GrantFiled: December 20, 2001Date of Patent: June 10, 2003Assignee: Dr Gottschall Instruction Gesellschaft fuer Technische Chromatographie mbHInventor: Klaus Gottschall
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Patent number: 6436925Abstract: Benzamides of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: R1—C1-C6-alkyl, branched or unbranched, where one of the C atoms in this chain may be substituted by a phenyl ring, cyclohexyl ring, indolyl ring and an SCH3 group, and the phenyl ring in turn is substituted by by [sic] a maximum of two R4 radicals, where R4 [lacuna] hydrogen, C1-C4-alkyl, branched or unbranched, —O—C1-C4-alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COO—C1-C4-alkyl, NHCO—C1-C4-alkyl, and R2 can be NR5CO—R6 and NHR5SO2—R6, and R3 is chlorine, bromine, fluorine, C1-C6-alkyl, NHCO—C1-C4-alkyl, NHSO2—C1-C4-alkyl, NO2, —O—C1-C4-alkyl, CN, COOH, CONH2, COO—C1-C4-alkyl, SO2—C1-C4-alkyl, —SO2Ph, SO2NH—C1-C4-alkyl, iodine, SO2NH2 and NH2, and A can be aromType: GrantFiled: October 3, 2000Date of Patent: August 20, 2002Assignee: Abbott LaboratoriesInventors: Wilfried Lubisch, Achim Möller, Hans-Jörg Treiber, Monika Knopp
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Publication number: 20020015938Abstract: The invention relates to a method of simultaneous high-throughput preformulation quantification of potential drug candidates, where an aliquot of a mixture of solutions containing different compounds is injected into a high pressure liquid chromatograph. The concentration of each compound can be determined by high pressure liquid chromatographic analysis, and correlated to a physico-chemical property of the compound.Type: ApplicationFiled: October 29, 1998Publication date: February 7, 2002Inventor: NARMADA SHENOY