Additional -c(=x) Bonded Directly To The Five-membered Hetero Ring (e.g., N N-butyryl-l-proline, Etc.) Patents (Class 548/533)
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Process For Preparing Prophyrin Derivatives, Such As Protoprophyrin (IX) And Synthesis Intermediates
Publication number: 20110306761Abstract: The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R? are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R?b is as defined above for (I), and a dipyrromethane of formula (III): in which R? is as defined in claim 1, and also the compounds of formula (III).Type: ApplicationFiled: August 25, 2011Publication date: December 15, 2011Applicant: SANOFI PASTEUR SAInventors: Pierre Martin, Markus Mueller, Dirk Spielvogel, Dietmar Flubacher, Andreas Boudier -
Publication number: 20110301096Abstract: This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.Type: ApplicationFiled: August 16, 2011Publication date: December 8, 2011Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventors: Marion W. Wannamaker, Robert Davies
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Publication number: 20110281928Abstract: The present invention relates to a process for the preparation of zofenopril and its pharmaceutically acceptable salts and a pharmaceutical composition thereof. The present invention also provides structurally novel compounds, which are useful intermediates in the synthesis of zofenopril.Type: ApplicationFiled: January 24, 2010Publication date: November 17, 2011Applicant: GLENMARK GENERICS LTDInventors: Mubeen Ahmed Khan, Roop Singh Yadav, Nikhil Rasiklal Trivedi, Sachin Mahedo Lad
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Publication number: 20110275792Abstract: A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.Type: ApplicationFiled: July 15, 2011Publication date: November 10, 2011Inventor: Thomas Piccariello
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Publication number: 20110269722Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.Type: ApplicationFiled: December 23, 2010Publication date: November 3, 2011Inventor: Apparao Satyam
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Publication number: 20110257130Abstract: Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related disorder. These compounds include lipoic acid derivatives such as prolyl lipoic acid and pipecolinyl lipoic acid, and other compounds, and these compounds are useful in treating hypertension, stroke, or other renin-angiotensin aldosterone system-related disorders in human or animal patients. Pharmaceutical compositions prepared using these compounds and methods of treatment using these compounds are also provided.Type: ApplicationFiled: October 16, 2009Publication date: October 20, 2011Inventor: Desikan Rajagopal
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Patent number: 8039495Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.Type: GrantFiled: October 15, 2010Date of Patent: October 18, 2011Assignee: Hoffman-La Roche Inc.Inventors: David Robert Bolin, Yimin Qian, Kshitij Chhabilbhai Thakkar, Lin Yi, Weiya Yun
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Publication number: 20110251403Abstract: In the present invention, a hydroxyl group substitution product is manufactured by reaction of an alcohol with sulfuryl fluoride (SO2F2) in the presence of an organic base and a nucleophile (X?). The present invention is thus effective as an industrial manufacturing method that uses a relatively cheap reagent suitable for large-scale applications and can be accomplished in a simple process with easy purification operation and less waste generation and is suitably applicable for manufacturing of optically active hydroxyl group substitution products, notably optically active ?-hydroxyl group substitution ester and optically active 4-hydroxyl group substitution proline. The manufacturing method of the present invention solves all of the prior art problems and can be applied for industrial uses.Type: ApplicationFiled: December 15, 2009Publication date: October 13, 2011Applicant: Central Glass Company, LimitedInventors: Akihiro Ishii, Manabu Yasumoto, Koji Ueda
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Patent number: 8026372Abstract: A process for the preparation of ?-alkoxycarbonylamino-?-aminoacids and ?,? orthogonally diprotected diaminoacids from ?,?-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of ?-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of ?-alkoxycarbonylamino-?-aminoacids with benzotriazoles are also disclosed.Type: GrantFiled: August 4, 2006Date of Patent: September 27, 2011Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.Inventors: Siro Serafini, Riccardo Motterle, Elena Brasola
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Publication number: 20110201825Abstract: Fluorosulfuric acid esters can be produced by reacting alcohols with sulfuryl fluoride (SO2F2) in the presence of a base and water. As a substrate thereof, optically active secondary alcohols are preferable, and optically active ?-hydroxyesters and optically active 4-hydroxyprolines are particularly preferable. By performing the reaction in a two-phase system in the presence of a reaction solvent immiscible with water, a desired reaction proceeds particularly well. The present invention is a production method solving all the problems involved in conventional techniques while being industrially practicable.Type: ApplicationFiled: October 15, 2009Publication date: August 18, 2011Applicant: Central Glass Company, LimitedInventors: Akihiro Ishii, Manabu Yasumoto
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Patent number: 7960570Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.Type: GrantFiled: December 8, 2009Date of Patent: June 14, 2011Assignee: GliaMed, Inc.Inventors: Gregory S. Hamilton, Joseph Steiner
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Publication number: 20110124881Abstract: Disclosed is a process of forming a pyrrole compound. The process comprises contacting an ?-carbonyl oxime compound 1 and an ?,?-unsaturated aldehyde 2 R1 and R2 in compound 1 are independently selected from the group consisting of H, a silyl-group, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group. The aliphatic, alicyclic, aromatic, arylaliphatic, and arylalicyclic groups comprise 0 to about 3 heteroatoms selected from the group N, O, S, Se and Si. R3 in aldehyde 2 is selected from the group consisting of H, a silyl-group, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group. The aliphatic, alicyclic, aromatic, arylaliphatic, and arylalicyclic groups comprise 0 to about 3 heteroatoms selected from the group N, O, S, Se and Si. The ?-carbonyl oxime compound 1 an the ?,?-unsaturated aldehyde 2 are contacted in a suitable solvent in the presence of a secondary amine.Type: ApplicationFiled: May 18, 2010Publication date: May 26, 2011Inventors: Guofu Zhong, Bin Tan, Zugui Shi, Pei Juan Chua
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Publication number: 20110118322Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.Type: ApplicationFiled: October 15, 2010Publication date: May 19, 2011Inventors: David Robert Bolin, Yimin Qian, Kshitij Chhabilbhai Thakkar, Lin Yi, Weiya Yun
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Publication number: 20110118328Abstract: The present invention relates to two novel crystalline forms of zofenopril calcium, to processes for their preparation and their use in pharmaceutical compositions.Type: ApplicationFiled: February 26, 2009Publication date: May 19, 2011Inventor: Vinayak Gore
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Publication number: 20110110858Abstract: Overexpression of angiotensin-converting enzyme (ACE) has been associated with a number of pathophysiologies, including those associated with cancer and the cardiovascular system. Thus, targeted imaging of ACE is of crucial importance for monitoring tissue ACE activity as well as treatment efficacy. To this end, lisinopril-coated gold nanoparticles were prepared to provide a new type of probe for targeted molecular imaging of ACE by tuned K-edge computed tomography (CT) imaging.Type: ApplicationFiled: November 12, 2010Publication date: May 12, 2011Inventors: Omer Aras, Thorsten Fleiter, Jean Jeudy, Marie-Christine Daniel
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Publication number: 20110104057Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.Type: ApplicationFiled: May 13, 2009Publication date: May 5, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Ludger Dinkelborg, Keith Graham, Mathias Berndt, Norman Koglin, Heribert Schmitt-Willich, Matthias Friebe, Lutz Lehmann
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Publication number: 20110086409Abstract: A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides a surfactant-based monolithic column, a method for separating molecules, and a process for preparing a surfactant monomer.Type: ApplicationFiled: March 30, 2009Publication date: April 14, 2011Inventors: Shahab Ahmed Shamsi, Jun He, Congying Gu
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Publication number: 20110082282Abstract: Processes using Allium tissue homogenates and extracts in a simple and cost-effective manner to maximize the yields and recovery of thiosulfinates from Allium tissues and related organisms possessing alliinase, LF synthase and/or S-alk(en)yl-L-cysteine sulfoxides are disclosed.Type: ApplicationFiled: October 5, 2010Publication date: April 7, 2011Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Kirk L. Parkin, Guodong Zhang
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Publication number: 20110077412Abstract: A process for separating the diastereomers of RSS— and SSS—N-?[1-carboxy-3-phenylpropyl]lysylproline is described. Previous chromatographic processes for separating the diastereomers of this peptide active substance, such as for example adsorption chromatography, exhibited disadvantages with regard to the solvents used and throughput. These disadvantages do not occur if basic ion exchangers are used in the chromatographic separation of the diastereomers. In particular, purely aqueous solutions may be used as the eluent.Type: ApplicationFiled: September 29, 2009Publication date: March 31, 2011Inventors: Frédéric Boisivon, Jean Debas, Gérard Richet
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Publication number: 20110065040Abstract: The present invention provides a photoresist composition comprising a resin, an acid generator and a compound represented by the formula (I): wherein R1 represents a C2-C12 alkyl group which can have one or more hydroxyl groups, etc., R2 and R3 each independently represent a hydrogen atom, etc., R4, R5 and R6 each independently represent a hydrogen atom, etc., A1 represents a single bond or a C1-C2 alkylene group in which one or more —CH2— can be replaced by —O—.Type: ApplicationFiled: September 13, 2010Publication date: March 17, 2011Applicant: Sumitomo Chemical Company, LimitedInventors: Tatsuro MASUYAMA, Mitsuhiro Hata
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Publication number: 20110039209Abstract: The present invention provides a compound represented by the formula (C1): wherein Rc2 represents a C6-C10 aromatic hydrocarbon group having at least one nitro group and Rc1 represents a group represented by the formula (1): wherein Rc4 represents a hydrogen atom etc., Rc5 represents a C1-C30 divalent hydrocarbon group, and Rc3 represents a group represented by the formula (3-1), (3-2) or (3-3): wherein Rc6, Rc7, Rc8, Rc9, Rc10, Rc11, Rc12, Rc13 and Rc14 each independently represent a C1-C30 hydrocarbon group, and a photoresist composition comprising a resin, an acid generator and the compound represented by the formula (C1).Type: ApplicationFiled: August 6, 2010Publication date: February 17, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tatsuro Masuyama, Mitsuhiro Hata
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Publication number: 20110028736Abstract: The present invention relates to zofenopril calcium form A substantially free of other forms of zofenopril calcium and to zofenopril calcium having a chemical purity of more than 98.5%. The present invention also relates to methods of preparing such zofenopril calcium. It further relates to compositions comprising such zofenopril calcium.Type: ApplicationFiled: October 14, 2010Publication date: February 3, 2011Applicant: Generics [UK] LimitedInventors: Vinayak G. Gore, Ashok D. Pehere, Avinash C. Gaikwad, Priyesh S. Vijaykar
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Patent number: 7850955Abstract: Gelling agents which contain a specific N-acylamino acid monoamide monoalkyl ester have a melting temperature of about 100° C., are capable of solidifying a wide variety of oily base materials including silicones, and do not cause “sweating” while retaining a practical level of gel strength. When applied to skin, the resulting gels have a good feeling, good spreadability, and good fittability to skin.Type: GrantFiled: July 3, 2008Date of Patent: December 14, 2010Assignee: Ajinomoto Co., Inc.Inventors: Keitaro Saito, Takanori Sugimoto, Tatsuya Hattori
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Publication number: 20100290991Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.Type: ApplicationFiled: November 19, 2009Publication date: November 18, 2010Applicant: BAYER SCHERING PHARMA AGInventors: Matthias FRIEBE, Heribert Schmitt-Willich, Mathias Berndt, Ludger Dinkelborg, Norman Koglin, Keith Graham
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Publication number: 20100249207Abstract: Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.Type: ApplicationFiled: January 19, 2010Publication date: September 30, 2010Applicant: Wyeth LLCInventors: Asaf R. Alimardanov, Lalitha Krishnan, Maotang Zhou, Ting-Zhong Wang, Jianxin Ren, John Leo Considine, Charles C. Wu, Jason Brazzillo, Panolil Raveendranath, Karen Sutherland, Mahmoud Mirmehrabi, Subodh S. Deshmukh, Girija Raveendranath, Vijay Raveendranath, Sanjay Raveendranath
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Patent number: 7799932Abstract: A family of N-substituted 3,4-alkylenedioxypyrrole includes monomers for of formula (I) electropolymerization to conjugated polymers and key intermediates for the preparation of the monomers. The preparation of the //-substituted 3,4-alkylenedioxypyrroles is carried out via a synthetic intermediate, an ester substituted dihydroxypyrrole. The synthetic method to prepare the //-substituted 3,4-alkylenedioxypyrrole intermediates and ultimately the N-substituted 3,4-alkylenedioxypyrrole monomers begins with a reaction to form the ester substituted dihydroxypyrrole.Type: GrantFiled: October 6, 2006Date of Patent: September 21, 2010Assignee: University of Florida Research Foundation, Inc.Inventors: John R. Reynolds, Ryan M. Walczak, John Sigure Cowart, II
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Publication number: 20100228037Abstract: A novel process of preparing allyl-containing asymmetric disulfides, and particularly therapeutically active allyl-containing asymmetric disulfides such as allylmercaptocaptopril (CPSSA) is disclosed.Type: ApplicationFiled: January 24, 2007Publication date: September 9, 2010Applicant: Yeda Research And Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Alexander Khenkin, Aharon Rabinkov, Talia Miron, Meir Wilchek, David Mirelman
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Publication number: 20100210837Abstract: This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin.Type: ApplicationFiled: April 18, 2008Publication date: August 19, 2010Inventor: Taifo Mahmud
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Publication number: 20100184768Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.Type: ApplicationFiled: November 12, 2009Publication date: July 22, 2010Applicant: SIGNUM BIOSCIENCES, INC.Inventors: Jeffry B. Stock, Maxwell Stock, Keshava Rapole, Seung-Yub Lee, Michael Voronkov, Eduardo Perez, Joel Gordon, Shuyi Chen, Jinglong Chen
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Publication number: 20100174096Abstract: Useful industrial methods for producing optically active fluoropyrrolidine derivatives as useful fluorinated intermediates are disclosed.Type: ApplicationFiled: December 28, 2009Publication date: July 8, 2010Applicant: IM&T RESEARCH, INC.Inventors: Teruo Umemoto, Rajendra P. Singh
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Publication number: 20100174084Abstract: The invention relates to novel 2-alkoxy-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) in which A, B, D, G, X, Y and Z are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the 2-alkoxy-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) and, secondly, at least one crop plant tolerance promoter compound.Type: ApplicationFiled: March 16, 2010Publication date: July 8, 2010Applicant: Bayer CropScience AGInventors: Reiner FISCHER, Stefan Lehr, Mark Wilhelm Drewes, Dieter Feucht, Olga Malsam, Guido Bojack, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne, Chris Rosinger
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Publication number: 20100144827Abstract: The present application discloses conjugates comprising an aminic moiety covalently linked to a hydrophobic moiety, through an amidic bond, which are selective inhibitors of COX-2 enzyme and can be beneficially used in the treatment of various inflammatory disease or disorder and cancer.Type: ApplicationFiled: December 20, 2007Publication date: June 10, 2010Applicant: MedWell Laboratories Ltd. c/o NGT Technological IncubatorInventors: Taher Nassar, Raiyn Nureldin, Anwar Rayan
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Publication number: 20100145071Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.Type: ApplicationFiled: December 8, 2009Publication date: June 10, 2010Applicant: GLIAMED, INC.Inventors: Gregory S. Hamilton, Joseph Steiner
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Publication number: 20100099727Abstract: The invention provides novel compounds of general formula I wherein R1, R2 and R3 are independently hydrogen, OR4, C1-C6 alkyl or C2-C6 alkenyl, R4 is hydrogen, C1-C6 alkyl or C2-C6 alkenyl, —N-(AA) represents the residue of an amino acid or of a peptide which is bonded over the N-terminus of the amino acid or the peptide and the peptide is composed of 2 to 6, that means 2, 3, 4, 5 or 6, amino acids, wherein the C-terminus of the amino acid or the peptide is optionally esterified with a C1-C16 hydrocarbon moiety and n is an integer of 1 to 5. The compounds are in particular useful for cosmetic applications.Type: ApplicationFiled: November 27, 2009Publication date: April 22, 2010Applicant: DSM IP ASSETS B.V.Inventors: Jochen Klock, Philippe Emmandel Maillan, Juergen H. Vollhardt, Raphael Beumer
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Publication number: 20100093733Abstract: Compounds of formula (I): or pharmaceutically acceptable salts and esters thereof, are useful for the treatment of obesity, type II diabetes and the metabolic syndrome.Type: ApplicationFiled: February 15, 2008Publication date: April 15, 2010Applicant: PROSIDION LIMITEDInventors: Oscar Barba, Graham Dawson, William Gattrell, Martin James Procter, Chrystelle Marie Rasamison, Colin Peter Sambrook-Smith, Philippe Wong-Kai-In
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Publication number: 20100087466Abstract: Methods of inhibiting HSP70 proteins, agents causing the inhibition of HSP70 proteins, and the effects of such inhibition on cell proliferation. Anti-microbial agents comprising small molecules, or pharmaceutical salts thereof, disclosed herein and further methods of use thereof are also disclosed. The disclosed small molecules, or pharmaceutical salts thereof, are effective in inhibiting microbial chaperone activity in microbes, such as homologs of HSP70. The disclosed small molecules, or pharmaceutical salts thereof, are also effective for the therapeutic treatment of cancer.Type: ApplicationFiled: September 3, 2009Publication date: April 8, 2010Inventors: Michael Alan Sturgess, Frank Kotch
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Patent number: 7652060Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.Type: GrantFiled: October 12, 2007Date of Patent: January 26, 2010Assignee: Glia Med, IncInventors: Gregory S. Hamilton, Joseph P. Steiner
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Patent number: 7652061Abstract: Compounds of the formula provide pharmacological agents which bind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis, Crohn's disease, and conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X.Type: GrantFiled: May 19, 2004Date of Patent: January 26, 2010Assignee: Novartis A.G.Inventors: Gary Michael Ksander, Thalaththani Ralalage Vedananda
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Publication number: 20090209585Abstract: The present invention relates to a cycloalkene derivative represented by the formula (I): wherein each symbol is as defined in the specification, a pharmaceutical agent containing the derivative, and a production method thereof. The cycloalkene derivative of the present invention has high solubility in water and is suitable for use as an injection.Type: ApplicationFiled: July 6, 2007Publication date: August 20, 2009Inventors: Takashi Ichikawa, Tomoyuki Kitazaki, Norikazu Tamura
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Publication number: 20090176860Abstract: The present invention relates to zofenopril calcium form A substantially free of other forms of zofenopril calcium and to zofenopril calcium having a chemical purity of more than 98.5%. The present invention also relates to methods of preparing such zofenopril calcium. It further relates to compositions comprising such zofenopril calcium.Type: ApplicationFiled: November 25, 2008Publication date: July 9, 2009Inventors: Vinayak G. Gore, Ashok D. Pehere, Avinash C. Gaikwad, Priyesh S. Vijaykar
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Publication number: 20090149661Abstract: A family of N-substituted 3,4-alkylenedioxypyrrole includes monomers for of formula (I) electropolymerization to conjugated polymers and key intermediates for the preparation of the monomers. The preparation of the //-substituted 3,4-alkylenedioxypyrroles is carried out via a synthetic intermediate, an ester substituted dihydroxypyrrole. The synthetic method to prepare the //-substituted 3,4-alkylenedioxypyrrole intermediates and ultimately the N-substituted 3,4-alkylenedioxypyrrole monomers begins with a reaction to form the ester substituted dihydroxypyrrole.Type: ApplicationFiled: October 6, 2006Publication date: June 11, 2009Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: John R. Reynolds, Ryan M. Walczak, John Sigure Cowart
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Publication number: 20090137611Abstract: The present invention relates to N-cyclopropyl-sulfonylamide derivatives of formula (I) wherein the substituents are cyclic groups, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions: (I)Type: ApplicationFiled: April 5, 2007Publication date: May 28, 2009Inventors: Hans-Georg Schwarz, Sandra Gassmann, Karl-Heinz Kuck, Peter Dahmen, Ulrike Wachendorff-Neumann, Stephane Carbonne, Stephanie Gary, Christopher Steele, Alain Villier, Jean-Pierre Vors
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Patent number: 7528264Abstract: Hydride process for making acyclic diol intermediates from cyclic intermediates, useful in antibacterial quinolone synthesis.Type: GrantFiled: March 26, 2007Date of Patent: May 5, 2009Assignee: The Procter & Gamble CompanyInventors: Michael Patrick Hayes, Tammy Talbot Schunk
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Publication number: 20090105091Abstract: The present invention provides a compound of the general formula (I), wherein X is the connection between the CO-hydrazine and the NR1-oxalic acid or ester group, and uses and synthesis methods. These compounds represent amino acid derivatives, wherein the amine group is turned into an acidic group by the oxalic acid group and the carboxylic acid is turned into an amine functionality by the hydrazine group; as well as peptidomimetics comprising the compound and methods for their synthesis.Type: ApplicationFiled: November 24, 2006Publication date: April 23, 2009Applicant: TECHNISCHE UNIVERSITAT WIENInventors: Ulrich Jordis, Jaywant B. Phopase
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Publication number: 20090104151Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: ApplicationFiled: April 11, 2008Publication date: April 23, 2009Applicant: Joyant Pharmaceuticals, IncInventors: Gunnar HANSON, Haizhou SUN
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Publication number: 20090082393Abstract: Compounds of formula (I): (A)m·(B)n??(I) wherein A represents an angiotensin-converting enzyme inhibitor compound containing at least one salt-forming basic function, B represents a compound containing at least one salt-forming acid function and at least one NO donor group, m represents the number of acid functions of B that have been converted to a salt and n represents the number of basic functions of A that have been converted to a salt, the bond or bonds between A and B being of the ionic type. Medicinal products containing the same which are useful in treating cardiovascular pathologies.Type: ApplicationFiled: September 17, 2008Publication date: March 26, 2009Applicant: LES LABORATOIRES SERVIERInventors: Guillaume De Nanteuil, Bernard Portevin, Philippe Gloanec, Jean-Gilles Parmentier, Alain Benoist, Tony Verbeuren, Alain Rupin, Christine Courchay, Serge Simonet
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Patent number: 7504429Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a substituted pyrrole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.Type: GrantFiled: July 20, 2004Date of Patent: March 17, 2009Assignee: Merck & Co., Inc.Inventors: Annette S. Kim, Xufang Zhang
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Publication number: 20090012149Abstract: This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.Type: ApplicationFiled: July 1, 2008Publication date: January 8, 2009Inventors: Marion W. Wannamaker, Robert Davies
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Publication number: 20080255369Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III, wherein R, R1, and R? are as defined in the specification, or a salt thereof, and a compound of formula IV wherein R, R1, R2 and R? are as defined in the specification, and processes of manufacturing these.Type: ApplicationFiled: September 26, 2006Publication date: October 16, 2008Inventors: Stuart John Mickel, Wolfgang Marterer
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Publication number: 20080249030Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid which is optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF3 groups and n=0.1 or 2, or X represents CH2, C?O, C?S, CHOH, R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.Type: ApplicationFiled: March 30, 2006Publication date: October 9, 2008Inventors: Pierre Potier, Marie-Claude Denise Michele Zelveyan, Catharine Marie Germaine Magnan