Bicyclo Ring System Having The Lactone Ring As One Of The Cyclos Patents (Class 549/269)
Additional acyclic chalcogen bonded directly to the lactone ring (e.g., zearalanone, etc.) (Class 549/270)
  • Heterocyclic synthesis via thallation and subsequent palladium-promoted olefination
    Patent number: 4647666
    Abstract: Functionally substituted arenes selected from the group consisting of p-tolylacetic acid, N-methylbenzamide, benzamide and acetanilide which are thallated provide an organothallium salt which undergoes subsequent palladium promoted olefination to provide oxygen and/or nitrogen heterocycles such as ethers lactones, isoquinolones, indoles and isocarbostyrils.
    Type: Grant
    Filed: July 15, 1985
    Date of Patent: March 3, 1987
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: Richard C. Larock
  • 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof
    Patent number: 4616034
    Abstract: The present invention provides novel compounds of Formula I ##STR1## which are pharmacologically selectively useful as anti-thrombotic agents with minimal blood pressure lowering activity.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: October 7, 1986
    Assignee: G. D. Searle & Co.
    Inventors: Stevan W. Djuric, Robert B. Garland
  • Lankacidin derivatives used in swine husbandry
    Patent number: 4425356
    Abstract: Compound of the formula: ##STR1## wherein R.sup.1 is .dbd.O or ##STR2## and R.sup.2 and R.sup.3 are each hydrogen or carboxylic acid-derived acyl, are effective for prophylaxis or treatment of swine dysentery or for increase of swine productivity.
    Type: Grant
    Filed: November 24, 1981
    Date of Patent: January 10, 1984
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Noriaki Narukawa, Keinosuke Takeda, Toshiyuki Yamazaki
  • Derivatives of 1,5-dimethylbicyclo [3,2,1] octane, the preparation of these compounds and their use as perfume compound
    Patent number: 4421689
    Abstract: Derivative compounds of 1,5-dimethylbicyclo [3,2,1] octane of the general formula ##STR1## and perfume compositions containing these derivatives, wherein X represents a C.dbd.O group, a ##STR2## group or a ##STR3## group, in which R.sub.1 and R.sub.2 are alkyl groups and R.sub.3 is an ethylene or trimethylene group which may be substituted with one or more alkyl groups. These derivative compounds may be prepared by oxidation of 1,5-dimethylbicyclo [3,2,1] octan-8-ol or an ester thereof optionally followed by reaction with an alkanol or a 1,2- or 1,3-alkane-diol.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: December 20, 1983
    Inventor: Albertus J. Mulder
  • Phenyl-alkanoic acid derivative and preparation thereof
    Patent number: 4367238
    Abstract: This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic activities.
    Type: Grant
    Filed: January 21, 1981
    Date of Patent: January 4, 1983
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Ikuo Ueda, Yoshihiko Kitaura, Masaaki Matsuo, Nobukiyo Konishi