Acyclic -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Lactone Ring Patents (Class 549/291)
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Patent number: 11555115Abstract: The present disclosure relates to a composition that includes a first repeat unit that includes where x is between 1 and 1,000, inclusively, and R1 includes at least one of a first hydrocarbon chain and/or a first hydrocarbon ring. In some embodiments of the present disclosure, R1 may further include at least one of an oxygen atom, a nitrogen atom, a sulfur atom, and/or a phosphorus atom.Type: GrantFiled: February 13, 2020Date of Patent: January 17, 2023Assignee: Alliance for Sustainable Energy, LLCInventors: Caroline Bradshaw Hoyt, Nicholas Rorrer, Gregg Tyler Beckham
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Patent number: 10358422Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic ?-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.Type: GrantFiled: November 1, 2018Date of Patent: July 23, 2019Assignee: California Institute of TechnologyInventors: Brian M. Stoltz, Aurapat Ngamnithiporn, Carina I. Jette, Shoshana Bachman, Scott C. Virgil, Sebastian Lackner
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Patent number: 9315495Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: June 19, 2013Date of Patent: April 19, 2016Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
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Patent number: 9187446Abstract: The invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and G are as described in the specification, as well as compositions comprising a compound of formula I, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: March 22, 2013Date of Patent: November 17, 2015Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright
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Patent number: 9133155Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Ya, Yb, R1, R2, and G are as described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: September 16, 2011Date of Patent: September 15, 2015Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright
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Publication number: 20150051275Abstract: The invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3 R4, R5, and G are as described in the specification, as well compositions comprising a compound of formula I, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: ApplicationFiled: March 22, 2013Publication date: February 19, 2015Inventors: Richard H. Ebright, Yon W. Ebright
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Patent number: 8822679Abstract: A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R11, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.Type: GrantFiled: June 22, 2012Date of Patent: September 2, 2014Assignee: California Institute of TechnologyInventors: Brian M Stoltz, Scott C. Virgil, David E White, Taiga Yurino, Yiyang Liu, Douglas C Behenna, Douglas Duquette, Christian Eidamshaus
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Patent number: 8772332Abstract: The invention provides a compound of formula (I): or a salt thereof, wherein R1-R4 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.Type: GrantFiled: September 7, 2011Date of Patent: July 8, 2014Inventor: Richard H. Ebright
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Publication number: 20140114068Abstract: Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.Type: ApplicationFiled: June 18, 2012Publication date: April 24, 2014Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Young Sik Jung, Chong Kgo Lee, Hae Soo Kim, Hee Chun Jeong, Pil Ho Kim, Soo Bong Han, Jin Soo Shin, Johan Neyts, Hendrik Jan Thibaut
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Publication number: 20140073688Abstract: A compound for use in a therapeutic treatment of filariasis or a prophylactic treatment of filariasis of the general formula (1) or at least one of racemates, enantiomers, diastereomers, solvates, hydrates, pharmaceutically acceptable salts, and esters of the general formula (1), a nematicidal composition comprising as an active ingredient a compound according to the general formula (1), and a method for treating filariasis.Type: ApplicationFiled: May 4, 2012Publication date: March 13, 2014Applicant: RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAET BONNInventors: Kenneth Michael Pfarr, Achim Hoerauf, Gabriele Maria Koenig, Sabine Specht, Andrea Schiefer, Till Friedrich Schaeberle, Alexander Schmitz, Stefan Kehraus
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Publication number: 20130345429Abstract: There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Ra represents an alkyl group, such as a C1-16 alkyl group, and preferably an isopropyl group; Rb represents an aryl group, preferably a 4-fluorophenyl group; Rc represents hydrogen, a protecting group or an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO2Re group where Re is an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group.Type: ApplicationFiled: July 26, 2013Publication date: December 26, 2013Inventors: David John Moody, Jonathan William Wiffen
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Publication number: 20130296421Abstract: The invention provides a compound of formula (I): or a salt thereof, wherein R1-R4 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.Type: ApplicationFiled: September 7, 2011Publication date: November 7, 2013Inventor: Richard H. Ebright
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Publication number: 20130237595Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Ya, Yb, R1, R2, and G are as described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: ApplicationFiled: September 16, 2011Publication date: September 12, 2013Inventors: Richard H. Ebright, Yon W. Ebright
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Publication number: 20130012701Abstract: A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R11, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.Type: ApplicationFiled: June 22, 2012Publication date: January 10, 2013Applicant: California Institute of TechnologyInventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
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Patent number: 8269024Abstract: The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occurring and non-naturally occurring acyl-homoserine lactone (AHL) analogs, and methods of synthesizing and using these compounds.Type: GrantFiled: December 17, 2009Date of Patent: September 18, 2012Assignee: Wisconsin Alumni Research FoundationInventors: Helen E. Blackwell, Grant D. Geske, Rachel Wezeman
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Publication number: 20110237776Abstract: Compounds useful as nutritional supplements, antioxidants, heavy metal chelators and/or as intermediates for producing other related compounds with like uses have a formula: where R1 is an aromatic backbone and R2 is a sulfur containing ligand.Type: ApplicationFiled: March 25, 2010Publication date: September 29, 2011Inventors: BOYD E. HALEY, Niladrl Narayan Gupta
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Patent number: 8008510Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.Type: GrantFiled: March 12, 2010Date of Patent: August 30, 2011Assignee: The Regents of the University of CaliforniaInventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
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Patent number: 7875327Abstract: A nematic liquid crystal compound represented by any one of formulas (a-1) to (a-6): in formulas (a-1) to (a-6), Ra and Rb are each independently hydrogen or alkyl having 1 to 10 carbons, provided that in the alkyl, —CH2- may be replaced by —O—, —(CH2)2- may be replaced by —CH?CH—, and hydrogen may be replaced by a halogen; ring A1 and ring A2 are each independently trans-1,4-cyclohexylene or 1,4-phenylene, provided that in these rings hydrogen may be replaced by a halogen, and in the case where the ring is trans-1,4-cyclohexylene, —CH2- may be replaced by —O—, and —CH2CH— may be replaced by —CH?C—; and Z1 and Z2 are each independently a single bond, —COO—, —OCO—, —OCH2-, —CH2O— or —CH2CH2-, provided that in formula (a-3), in the case where ring A2 is trans-1,4-cyclohexylene, Z2 is a single bond, —COO—, —OCO—, —OCH2- or —CH2O—, in the case where Ra is —C3H7, Rb is —OC2H5, and Z2 is a single bond, ring A2 is trans-1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 2-fluoro- 1,4-phenylene, 3-fluoro-1,4-phenylene, 2-fType: GrantFiled: October 2, 2009Date of Patent: January 25, 2011Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventors: Mayumi Goto, Teruyo Sugiura, Norikatsu Hattori
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Publication number: 20100204356Abstract: A high-elasticity biodegradable polymer comprising PDC, which has excellent solubility in solvents and reactants, in their repeating unit structures is provided in an inexpensive manner. A polymer comprising a repeating unit represented by the following formula (I): wherein R1 and R2 each independently represent a divalent hydrocarbon residue with no active hydrogens in its structure and optionally containing a heteroatom; X represents O or NH; x represents an integer of at least 1; and m and n represent 0 or 1; and a process for their production.Type: ApplicationFiled: September 4, 2008Publication date: August 12, 2010Applicant: KABUSHIKI KAISHA TOYOTA JIDOSHOKKIInventors: Yusuke Yamamoto, Osamu Ohmori, Hitotoshi Murase, Hiroaki Takashima, Kohei Mase, Tomokuni Abe, Toshihisa Shimo
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Patent number: 7691883Abstract: The present invention relates to a cinnamoyl compound represented by the formula (I):Type: GrantFiled: September 16, 2004Date of Patent: April 6, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Yoshitaka Tomigahara, Kiyoshi Higashi, Junya Takahashi, Chizuko Takahashi
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Publication number: 20100004469Abstract: An antimicrobial agent comprising, as an active component, compounds represented by the following formula [wherein, R1 and R2 each independently represent H or an alkali metal atom.]; and a microbicidal agent comprising, as an active component, compounds represented by formula (I): [wherein, R1 and R2 each independently represent H or an alkali metal atom.], wherein they have high safety and little impact on the environment.Type: ApplicationFiled: December 18, 2007Publication date: January 7, 2010Applicants: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI, J-CHEMICAL, INC.Inventors: Kiyotaka Shigehara, Masami Bito, Yoshihiro Katayama
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Patent number: 7642285Abstract: The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occurring and non-naturally occurring acyl-homoserine lactone (AHL) analogs, and methods of synthesizing and using these compounds.Type: GrantFiled: February 2, 2006Date of Patent: January 5, 2010Assignee: Wisconsin Alumni Research FoundationInventors: Helen E. Blackwell, Grant D. Geske, Rachel W. Wezeman
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Patent number: 7537775Abstract: Stable skin care compositions comprising dehydroacetic acid and a dermatologically acceptable carrier. The dermatologically acceptable carrier comprises at least one oil, said oil having a solubility in water of about 5% or less and a solubility parameter of from about 7 to about 15, and the dehydroacetic acid is distributed primarily into said oil. The compositions have a pH of about 4.5 and below.Type: GrantFiled: January 25, 2006Date of Patent: May 26, 2009Assignee: The Procter & Gamble CompanyInventors: Timothy Woodrow Coffindaffer, Robert Bao Kim Ha, Margaret Ann O'Donoghue, Larry Richard Robinson
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Publication number: 20090043115Abstract: The present invention discloses a process for producing Simvastatin and intermediate thereof. The present invention uses inexpensive and easily available reagents, its condition is mild, and it leaves out the protective and deprotective steps, which are necessary in prior methods. Compared with prior art, the esterifying condition in 8-position is greatly simplified.Type: ApplicationFiled: September 26, 2005Publication date: February 12, 2009Applicant: PFICKER PHARMACEUTICALS LTD.Inventors: Hongping Ye, Meg M. Sun, Zuolin Zhu
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Patent number: 7473790Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.Type: GrantFiled: May 8, 2006Date of Patent: January 6, 2009Assignee: Pfizer Inc.Inventors: Allen Borchardt, Javier Gonzalez, Hui Li, Maria Angelica Linton, John Howard Tatlock
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Publication number: 20040102488Abstract: The present invention relates to new compounds of the general formula (I), 1Type: ApplicationFiled: July 15, 2003Publication date: May 27, 2004Inventors: Barbara Beck, Alexander Domling
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Publication number: 20040044228Abstract: A fluorescent probe for measuring magnesium ion, which can selectively form a complex with magnesium ion in aqueous system is disclosed.Type: ApplicationFiled: July 18, 2003Publication date: March 4, 2004Inventors: Koji Suzuki, Yoshio Suzuki, Kotaro Oka
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Publication number: 20030191027Abstract: There are described derivatives of benzoylcyclohexanediones of the formula (I) and their use as herbicides.Type: ApplicationFiled: September 10, 2002Publication date: October 9, 2003Inventors: Thomas Seitz, Lothar Willms, Andreas van Almsick, Hermann Bieringer, Thomas Auler, Hubert Menne
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Patent number: 6509298Abstract: 4-Hydroxy-6-methyl-3-(3-methylbutanoyl)-2-pyrone has a rapid controlling effect against arthropods such as Dictyoptera insects (e.g. German cockroach, smokybrown cockroach).Type: GrantFiled: September 20, 2001Date of Patent: January 21, 2003Assignee: Sumitomo Chemical Company, LimitedInventors: Shunichi Kubota, Michihiko Fujinami
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Patent number: 6509299Abstract: A pyrone compound given by formula (1) wherein R represents a trifluoromethyl group, hydrogen atom or methyl group, has an excellent effect for controlling harmful pests.Type: GrantFiled: May 2, 2002Date of Patent: January 21, 2003Assignee: Sumitomo Chemical Company, LimitedInventor: Michihiko Fujinami
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Patent number: 6414122Abstract: Embodiments include reagents to modify a bioactive species for incorporating a bifunctional boronic compound complexing moiety for subsequent conjugation to a different or same bioactive species having pendant phenylboronic acid moieties of General Formula I, wherein group R is an electrophilic or nucleophilic moiety suitable for reaction of the putative bifunctional boronic compound complexing reagent with a bioactive species, wherein group R2 is selected from one of H and OH moieties, and wherein group R3 is selected from one of an alkyl and a methylene bearing an electronegative substituent. Group Z is a spacer selected from (CH2)n and CH2O(CH2CH2O)n2, wherein n is an integer of from 1 to 5, and wherein n2 is an integer of from 1 to 4. Group Z2 and Z3 is a spacer and need not be the same.Type: GrantFiled: August 29, 2000Date of Patent: July 2, 2002Assignee: Prolinx, Inc.Inventors: Clarence N. Ahlem, Robert J. Kaiser, Kevin P. Lund, Mark L. Stolowitz
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Patent number: 6340739Abstract: A polyamide having repeating units represented by formula (1), wherein R1 represents a divalent hydrocarbon residue optionally having in the structure a heteroatom having no active hydrogen. The polyamide has a high refractive index, is biodegradable, and is useful as a material for fibers and plastics.Type: GrantFiled: October 20, 2000Date of Patent: January 22, 2002Assignees: Cosmo Research Institute, Cosmo Oil Co., Ltd.Inventors: Kiyotaka Shigehara, Yoshihiro Katayama, Seiji Nishikawa, Yasushi Hotta
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Patent number: 6271180Abstract: The present invention relates to novel compounds of the formula (I) in which Het represents one of the groups in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, and to their use as pesticides and herbicides.Type: GrantFiled: April 14, 2000Date of Patent: August 7, 2001Assignee: Bayer AktiengesellschaftInventors: Volker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Alan Graff, Udo Schneider
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Patent number: 6239291Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: May 18, 2000Date of Patent: May 29, 2001Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston UniversityInventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6228882Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: September 15, 1999Date of Patent: May 8, 2001Assignees: Anadys Pharmaceuticals, Inc., Scriptgen Pharmaceuticals, Inc.Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6191288Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: September 15, 1999Date of Patent: February 20, 2001Assignee: Anadys Pharmaceuticals, Inc.Inventor: P. Siva Ramamoorthy
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Patent number: 6184393Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: September 15, 1999Date of Patent: February 6, 2001Assignees: Trustees of Boston University, Scriptgen Pharmaceuticals, Inc.Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6127551Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: August 9, 1999Date of Patent: October 3, 2000Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston UniversityInventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6100292Abstract: This invention relates to ketones represented by the following formula ##STR1## and to drugs in which such a ketone or pharmacologically acceptable salt thereof is an effective component.The ketones of the present invention encourage the production of platelets, red blood cells, white blood cells and the like, and can be used to prevent or treat cytopaenia brought about by cancer chemotherapy, radiotherapy, bone marrow transplantation and drug therapy, or by immunological abnormality or anaemia, and the like.Type: GrantFiled: May 25, 1999Date of Patent: August 8, 2000Assignee: Toray Industries, Inc.Inventors: Tsuyoshi Matsumoto, Hideki Kawai, Kiyoshi Okano, Katsuyuki Mori, Yasumoto Adachi
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Patent number: 6096740Abstract: The present invention relates to pharmaceutical compositions for preventing or alleviating neurotoxicity. Said pharmaceutical compositions comprise as their active ingredient the stereospecific (+) enantiomers, having (3S,4S) configuration, of .DELTA..sup.6 -tetrahydrocannabinol (THC) type compounds of general formula (I), as defined hereinbelow.Type: GrantFiled: September 28, 1998Date of Patent: August 1, 2000Assignees: Ramot University Authority for Applied Research and Industrial Development Ltd., Yissum Research Develpoment Company of the Hebrew University in JersusalemInventors: Raphael Mechoulam, Emil Pop, Mordechai Sokolovsky, Yoel Kloog, Anat Biegon
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Patent number: 6090953Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: August 9, 1999Date of Patent: July 18, 2000Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston UniversityInventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6022983Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: January 2, 1998Date of Patent: February 8, 2000Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston UniversityInventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
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Patent number: 6020502Abstract: A method for the fluorination of 1,3-diketones and 1,3-ketoesters is disclosed.Type: GrantFiled: February 21, 1997Date of Patent: February 1, 2000Assignee: BNFL Fluorochemicals Ltd.Inventors: Richard D. Chambers, John Hutchinson, Martin P. Greenhall, John S. Moilliet, Julie Thomson
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Patent number: 5986111Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.Type: GrantFiled: March 21, 1997Date of Patent: November 16, 1999Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston UniversityInventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tau Hu, Jennifer V. Schaus
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Patent number: 5977029Abstract: The invention relates to novel 3-aryl-5-halogeno-pyrone derivatives of the formula (I) ##STR1## in which A, D, G, X, Y, Z and n are each as defined in the description,to a plurality of processes and intermediates for their preparation and to their use as pesticides and herbicides.Type: GrantFiled: April 20, 1998Date of Patent: November 2, 1999Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Folker Lieb, Michael Ruther, Jorg Stetter, Markus Dollinger, Christoph Erdelen, Norbert Mencke, Hans-Joachim Santel, Andreas Turberg, Ulrike Wachendorff-Neumann
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Patent number: 5972237Abstract: Heterocyclic compounds IR.sup.1 --X--L (I)whereL is a cyclic carbamate residue, a lactonoxy residue or a lactam residue,X is an oxygen-containing group ##STR1## where A is a linker, and R.sup.1 is an organic radical or a group L,are used as activators for inorganic peroxy compounds, in particular as cold bleach activators or optical brighteners in detergents, cleaners and bleaches and in disinfectants.Type: GrantFiled: November 17, 1997Date of Patent: October 26, 1999Assignee: BASF AktiengesellschaftInventors: Reinhard Muller, Thomas Wehlage, Wolfgang Trieselt, Alfred Oftring, Elisabeth Kappes, Gunter Oetter, Dieter Boeckh, Roland Ettl, Albert Hettche
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Patent number: 5905090Abstract: Analogues of the active metabolite of leflunomide, and to the use thereof as immunosuppressive and/or antinflammatory agents.Type: GrantFiled: April 29, 1998Date of Patent: May 18, 1999Assignee: Italfarmaco S.p.A.Inventors: Giorgio Bertolini, Mauro Biffi, Flavio Leoni, Maria Letizia Marchetti, Jacques Mizrahi, Flavio Somenzi, Paolo Mascagni
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Patent number: 5808062Abstract: The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.Type: GrantFiled: October 12, 1994Date of Patent: September 15, 1998Assignee: Warner-Lambert CompanyInventors: John Michael Domagala, Edmund Lee Ellsworth, Elizabeth Lunney, Daniel Fred Ortwine, Kimberly Suzanne Para, Josyula Venkata Nagendra Vara Prasad, Tomi Sawyer, Bradley Dean Tait
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Patent number: 5670662Abstract: A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; andY is formyl or protected formyl.Type: GrantFiled: March 28, 1996Date of Patent: September 23, 1997Assignee: Zeneca LimitedInventors: John Crosby, Andrew Blacker, John Albert Leslie Herbert
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Patent number: 5527916Abstract: A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centers which comprises selective reaction of at least one isomer with a reagent catalyzed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; andY is formyl or protected formyl.Type: GrantFiled: August 1, 1994Date of Patent: June 18, 1996Assignee: Zeneca LimitedInventors: Andrew J. Blacker, John Crosby, John A. L. Herbert