Two Of The Cyclos Share At Least Three Ring Members Or Ring Carbon Is Shared By The Three Cyclos (e.g., Bridged Or Peri Compounds, Etc.) Patents (Class 549/300)
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Patent number: 7833694Abstract: Lactone-containing compounds having formula (1) are novel wherein R1 is H, F, methyl or trifluoromethyl, R2 and R3 are H or monovalent hydrocarbon groups, or R2 and R3 may together form an aliphatic hydrocarbon ring, R4 is H or CO2R5, R5 is a monovalent hydrocarbon group, W is CH2, O or S, and k1 is 3, 4 or 5. They are useful as monomers to produce polymers which are transparent to radiation ?500 nm. Radiation-sensitive resist compositions comprising the polymers as base resin exhibit excellent properties including resolution, LER, pattern density dependency and exposure margin.Type: GrantFiled: March 12, 2009Date of Patent: November 16, 2010Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Koji Hasegawa, Satoshi Shinachi, Katsuhiro Kobayashi, Tsunehiro Nishi, Takeshi Kinsho
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Publication number: 20100152400Abstract: A polymerizable compound having a lactone structure represented by formula (1) is provided: wherein A represents a polymerizable site; R2 represents a single bond or an alkylene group; R3 represents a hydrocarbon group in which hydrogen atoms are substituted with a fluorine atom; R4 represents a halogen atom, a cyano group, a hydroxy group, an amide group, an alkyl group, a cycloalkyl group, an alkoxy group, a phenyl group, an acyl group, an alkoxycarbonyl group, or a group represented by R—C(?O)— or R—C(?O)O—, wherein R represents an alkyl group or a cycloalkyl group; X represents an alkylene group, an oxygen atom or a sulfur atom; Z represents a single bond, an ether bond, an ester bond, an amide bond, a urethane bond or a urea bond; n represents an integer of from 0 to 5; and m represents an integer of from 0 to 7.Type: ApplicationFiled: December 11, 2009Publication date: June 17, 2010Applicant: FUJIFILM CORPORATIONInventors: Yusuke IIZUKA, Kaoru IWATO, Hiroshi SAEGUSA, Shuji HIRANO
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Publication number: 20100112482Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.Type: ApplicationFiled: October 29, 2009Publication date: May 6, 2010Inventors: Takeru WATANABE, Satoshi SHINACHI, Takeshi KINSHO, Koji HASEGAWA, Yuji HARADA, Jun HATAKEYAMA, Kazunori MAEDA, Tomohiro KOBAYASHI
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Publication number: 20100099042Abstract: A polymerizable anion-containing sulfonium salt having formula (1) is provided wherein R1 is H, F, methyl or trifluoromethyl, R2, R3 and R4 are C1-C10 alkyl, alkenyl or oxoalkyl or C6-C18 aryl, aralkyl or aryloxoalkyl, or two of R2, R3 and R4 may bond together to form a ring with S, A is a C2-C20 hydrocarbon group having cyclic structure, and n is 0 or 1. The sulfonium salt generates a very strong sulfonic acid upon exposure to high-energy radiation. A resist composition comprising a polymer derived from the sulfonium salt is also provided.Type: ApplicationFiled: October 16, 2009Publication date: April 22, 2010Inventors: Masaki OHASHI, Youichi OHSAWA, Takeshi KINSHO, Jun HATAKEYAMA, Selichiro TACHIBANA
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Patent number: 7678530Abstract: Lactone-containing compounds having formula (1) are novel wherein A1 is a polymerizable functional group having a double bond, R1 is a monovalent C1-C10 hydrocarbon group in which some or all hydrogen atoms are substituted by fluorine atoms, and W is CH2, O or S. They are useful as monomers to produce polymers for the formulation of radiation-sensitive resist compositions which have high transparency to radiation of up to 500 nm and exhibit good development properties. Radiation-sensitive resist compositions comprising the polymers as base resin exhibit high resolution and prevent dissolution in water and penetration of water when processed by immersion lithography.Type: GrantFiled: January 4, 2007Date of Patent: March 16, 2010Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Koji Hasegawa, Satoshi Watanabe, Jun Hatakeyama, Takeshi Kinsho, Seiichiro Tachibana
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Publication number: 20090272295Abstract: A coating material including a low-molecular or medium-molecular organic compound represented by general formula (1). (In the formula, R1 is a single bond, methylene, ethylene or oxygen; and R2 is a hydrogen atom, or a hydrocarbon group, a fluorine-containing alkyl group, a cyclic form containing an aromatic group or aliphatic group, which may contain hydroxy group, carboxyl group, amino group, amide group, imide group, glycidyl group, cyano group, fluorocarbinol group, sulfonic group or sulfonylamide group, and a complex thereof, and may contain a fluorine atom, oxygen atom, nitrogen atom, silicon atom or sulfur atom, and R2's of the same type or different type may be connected by an ester bond, amide bond, ether bond, thioether bond, thioester bond or urethane bond.). This compound can be derived from a diol compound and bicyclo[2.2.2]octane-2,3:5,6-tetracarboxylic anhydride.Type: ApplicationFiled: September 5, 2006Publication date: November 5, 2009Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Satoru Miyazawa, Satoru Kobayashi, Kazuhiko Maeda
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Publication number: 20090208871Abstract: A resist composition including a base component (A) that exhibits changed solubility in an alkali developing solution under the action of acid, and an acid generator component (B) that generates acid upon exposure, wherein the acid generator component (B) includes an acid generator (B1) consisting of a compound represented by general formula (b1-2) shown below: [Chemical Formula 1] A+Z???(b1-2) wherein A+ represents an organic cation; and Z? represents an anionic cyclic group, wherein the cyclic group includes an ester linkage within the ring structure, two mutually different groups are bonded to the ring structure, one of these groups includes an ester linkage in which a carbon atom that constitutes part of the ester linkage is bonded directly to the ring structure, and the other group includes an anion moiety.Type: ApplicationFiled: February 16, 2009Publication date: August 20, 2009Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Akiya Kawaue, Keita Ishiduka, Kensuke Matsuzawa, Yoshiyuki Utsumi, Hiroaki Shimizu
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Patent number: 7193041Abstract: Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2+ and a coordination number of 6. A method for synthesizing the metal ion-CM-Asp complex is also described. Further, the metal ion-CM-Asp complex can be used for screening protein function.Type: GrantFiled: April 19, 2001Date of Patent: March 20, 2007Assignee: Clontech Laboratories, Inc.Inventors: Brian Perry, Paul S. Nelson, Te-Tuan Yang, Thomas H. Smith
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Patent number: 7105684Abstract: An object of the present invention is to provide a novel monomer compound having a lactone structure which gives polymers having more excellent feature as resist material, etc. The present invention relates to a compound represented by the following formula [1]: wherein R1 and R2 are an alkyl group; R3 and R4 are each independently hydrogen atom or an alkyl group; R5 is hydrogen atom, acryloyl group or methacryloyl group; and X is a methylene group which may have an alkyl group or an ethylene group which may have an alkyl group. The present invention provides a compound having a lactone structure which gives a polymer having more excellent feature particularly as a resist material and also provides a hydroxy lactone being useful as a material, etc. therefor.Type: GrantFiled: July 26, 2004Date of Patent: September 12, 2006Assignee: Takasago International CorporationInventors: Tomoya Sawaki, Hiroyuki Kenmochi, Yoji Hori
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Patent number: 7037995Abstract: Novel tertiary (meth)acrylate compounds having a lactone structure are polymerizable into polymers having improved transparency, especially at the exposure wavelength of an excimer laser and dry etching resistance. Resist compositions comprising the polymers are sensitive to high-energy radiation, have a high resolution, and lend themselves to micropatterning with electron beams or deep-UV rays.Type: GrantFiled: September 29, 2003Date of Patent: May 2, 2006Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeru Watanabe, Takeshi Kinsho, Koji Hasegawa
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Patent number: 7019151Abstract: Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R1 together with R2=O (oxo); R2=OH, or, R1 and R2 together=O (oxo); CR3R5 and CR4R6 are selected from CH2, CHOH and CROH; at least one of R1, R5 and R6 is R; and at least one of CR3R5 and CR4R6 is CH2.Type: GrantFiled: December 16, 2003Date of Patent: March 28, 2006Assignee: Pharmagenesis, Inc.Inventors: Dongcheng Dai, John H. Musser
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Patent number: 6962938Abstract: The present application describes novel spiro-cyclic ?-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-? converting enzyme (TACE), and/or aggrecanase inhibitors.Type: GrantFiled: December 18, 2003Date of Patent: November 8, 2005Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Gregory R. Ott, Xiao Tao Chen, Jingwu Duan, Matthew E. Voss
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Publication number: 20040235944Abstract: The invention relates to pseudolaric acid-B derivatives of general formula (I), wherein (a) R1 is cyano, heterocyclyl, COXR′ or CON(R′)2, wherein X is O or NH, R′ is H, cycloalkyl, alkyl, heterocyclic alkyl or arylalkyl, each R″ is independently alkyl, cycloalkyl or heterocyclicalkyl; (b) R2 is H, alkylacyl, arylalkylacyl, arylacyl or heterocyclylacyl; (c) R3 is COXY, amino or halogen, wherein X is O or NH, Y is H, NH2, hydroxy, alkyl, cycloalkyl, heterocyclicalkyl, hetroatom-substituted alkyl, tertiary amino-substituted ammonioalkyl, aryl, arylalkyl or polyhydroxyalkyl. The invention also relates to processes for preparing such derivatives and antitumor or antifungal pharmaceutical compositions containing the same.Type: ApplicationFiled: February 13, 2004Publication date: November 25, 2004Inventors: Jianmin Yue, Shengping Yang, Jian Ding, Dong Xiao, Shengtao Yuan
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Patent number: 6784302Abstract: An optically active lactone compound is produced by using a Zr(salen) complex of the following formula (I) or its enantiomer as a catalyst and subjecting a cyclic ketone compound to a Baeyer-Villiger reaction with at least one oxidizer selected from hydrogen peroxide, aqueous hydrogen peroxide and urea-hydrogen peroxide adduct in a solvent: wherein Ar1 is an aryl group having a carbon number of 10 to 16 and Y is a phenoxy group or an alkoxy group having a carbon number of 1 to 10.Type: GrantFiled: April 3, 2003Date of Patent: August 31, 2004Assignee: Kyushu UniversityInventors: Tsutomu Katsuki, Akira Watanabe, Tatsuya Uchida
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Patent number: 6753125Abstract: A photosensitive polymer having a protecting group including a fused aromatic ring, and a photoresist composition including the photosensitive polymer are provided. The photosensitive polymer has an acid-labile protecting group at its polymer backbone, the acid-labile protecting group including a fused aromatic ring having formula: where R1 is hydrogen atom or alkyl group having from 1 to 4 carbon atoms; X is hydrogen atom, halogen, alkyl, or alkoxy; and y is an integer from 1 to 3, wherein the fused aromatic ring is a liner ring or branched ring with y greater than or equal to 2. A photoresist composition is also provided which includes the photosensitive polymer and a photoacid generator (PAG).Type: GrantFiled: June 25, 2001Date of Patent: June 22, 2004Assignee: Samsung Electronics, Co. LTDInventors: Sang-jun Choi, Yool Kang
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Patent number: 6720430Abstract: The present invention discloses a compound having the following formula (I), wherein R1 is H, haloalkyl group or C1-C4 alkyl group; R2 is hydroxyl group, C1-C8 alkoxy group or C1-C8 thioalkyl group; G is (CH2)n, O or S, wherein n is 0, 1, 2, 3 or 4; Rc is a lactone group; and m is 1, 2 or 3. This compound is a monomer and suitable for synthesis to form polymers with good hydrophilicity, adhesion and dry-etch resistance. Particularly, this compound can form photosensitive polymers or copolymers by reacting with suitable photosensitive monomers.Type: GrantFiled: May 28, 2002Date of Patent: April 13, 2004Assignee: Everlight USA, Inc.Inventors: Chi-Sheng Chen, Yen-Cheng Li, Meng-Hsum Cheng
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Publication number: 20030229234Abstract: The present invention discloses a compound having the following formula (I), 1Type: ApplicationFiled: May 28, 2002Publication date: December 11, 2003Applicant: Everlight USA, Inc.Inventors: Chi-Sheng Chen, Yen-Cheng Li, Meng-Hsum Cheng
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Patent number: 6517994Abstract: The invention discloses a novel polymerizable (meth)acrylate ester compound having a lactone ring structure represented by the general formula in which R1 is a hydrogen atom or a methyl group. A synthetic route for the preparation of this (meth)acrylate ester compound is described. This monomeric compound can readily be polymerized into a (co)polymer which is useful as a base resinous ingredient in a chemically amplified photoresist composition having advantages in respects of high transparency to short-wavelength ultraviolet light for patterning exposure and excellent resistance against dry etching in addition to the high sensitivity, fine pattern resolution and excellent adhesion to the substrate surface.Type: GrantFiled: March 27, 2002Date of Patent: February 11, 2003Assignee: Shin-Etsu Chemical Co., Ltd.Inventor: Takeru Watanabe
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Publication number: 20020198390Abstract: Acrylic esters containing fluorine at &agr;-position and having a lactone ring introduced into the ester side chain thereof are novel. Polymers obtained from the acrylic esters have a high transparency to VUV and good adhesion to substrates and are used to formulate chemically amplified resist compositions for lithographic microfabrication.Type: ApplicationFiled: June 25, 2002Publication date: December 26, 2002Applicant: Shin-Etsu Chemical Co., Ltd.Inventors: Yuji Harada, Jun Hatakeyama, Yoshio Kawai, Michitaka Ootani, Satoru Miyazawa, Kentaro Tsutsumi, Kazuhiko Maeda
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Publication number: 20020147291Abstract: The invention discloses a novel polymerizable (meth)acrylate ester compound having a lactone ring structure represented by the general formula 1Type: ApplicationFiled: March 27, 2002Publication date: October 10, 2002Applicant: Shin-Etsu Chemical Co., Ltd.Inventor: Takeru Watanabe
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Patent number: 6461788Abstract: Disclosed herein are polymerizable compounds represented by the following formula (1): wherein R1 to R9 each independently represent a hydrogen atom, a silyl group, a cyano group, a hydroxyl group, a halogen atom or a monovalent nonpolymerizable organic substituent group, and A represents a polymerizable group having a carbon-carbon double bond; polymers obtained by singly polymerizing the polymerizable compounds or copolymerizing them with copolymerizable compounds; and resist compositions comprising the polymers. These polymers are useful as base polymers for resist materials for an exposure light source of a short wavelength.Type: GrantFiled: August 15, 2000Date of Patent: October 8, 2002Assignee: Maruzen Petrochemical Co., Ltd.Inventors: Takuya Miwa, Nobuyuki Oka, Masao Kaneko
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Publication number: 20020143194Abstract: A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (−)-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.Type: ApplicationFiled: February 11, 2002Publication date: October 3, 2002Applicant: Emory UniversityInventors: Dennis C. Liotta, Raymond F. Schinazi, Woo-Baeg Choi
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Publication number: 20020076641Abstract: A photosensitive polymer having a protecting group including a fused aromatic ring, and a photoresist composition including the photosensitive polymer are provided.Type: ApplicationFiled: June 25, 2001Publication date: June 20, 2002Applicant: Samsung Electronics Co., Ltd.Inventors: Sang-Jun Choi, Yool Kang
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Patent number: 6280898Abstract: A novel lactone-containing compound is provided as well as a polymer comprising units of the compound. The polymer is used as a base resin to formulate a resist composition having a high sensitivity, resolution and etching resistance.Type: GrantFiled: September 24, 1999Date of Patent: August 28, 2001Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Koji Hasegawa, Tsunehiro Nishi, Takeshi Kinsho, Jun Hatakeyama, Osamu Watanabe
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Patent number: 6232083Abstract: The present invention provides a metal charged iminodiacetic acid (IDA) cellulose for detecting a test sample having a histidine tag. The present invention also provides methods for determining cloned protein expression and function. Additionally, the present invention includes a method for the handling of denatured proteins with subsequent renaturation in situ (parenthetically after binding to metal charged IDA cellulose). A wide range of applications are contemplated for the metal charged IDA cellulose including two-dimensional high throughput screening of proteins.Type: GrantFiled: March 12, 1999Date of Patent: May 15, 2001Assignee: The Research Foundation of State University of New YorkInventors: Paul A. Fisher, Alexander Zaika
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Patent number: 5965604Abstract: The present invention relates to chrolactomycin compound represented by the following formula (I): ##STR1## or pharmaceutically acceptable salts thereof having antibacterial and antitumor activities.Type: GrantFiled: December 17, 1998Date of Patent: October 12, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoshinori Yamashita, Ryuichiro Nakai, Tamio Mizukami, Shingo Kakita, Shigeru Chiba, Shiro Akinaga
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Patent number: 5962641Abstract: Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2.sup.+ and a coordination number of 6. A method for synthesizing the metal ion-CM-Asp complex is also described. Further, the metal ion-CM-Asp complex can be used for screening protein function.Type: GrantFiled: August 16, 1996Date of Patent: October 5, 1999Assignee: CLONTECH Laboratories, Inc.Inventors: Paul S. Nelson, Te-Tuan Yang, Steven R. Kain
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Patent number: 5859284Abstract: The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.Type: GrantFiled: August 23, 1996Date of Patent: January 12, 1999Assignee: Gilead Sciences, Inc.Inventors: Kenneth M. Kent, Choung U. Kim, Lawrence R. McGee, John D. Munger, Jr., Ernest J. Prisbe, Michael J. Postich, John C. Rohloff, Daphne E. St. John, Matthew A. Williams, Lijun Zhang
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Patent number: 5811462Abstract: Peptide analogs containing norbornene are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.Type: GrantFiled: May 2, 1997Date of Patent: September 22, 1998Assignee: Merck & Co., Inc.Inventors: Randall W. Hungate, Joseph P. Vacca, Byeong Moon Kim
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Patent number: 5723487Abstract: This invention refers to a process for creating a product useful in the treatment of disorders related to collagen production and function.Type: GrantFiled: February 13, 1995Date of Patent: March 3, 1998Inventors: Antonio Sumi Horvath, deceased, by Judith Tobar Goycolea, legal representative, by Antonio Sumi Horvath, legal representative, by Dora Kiss Horvath, legal representative
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Patent number: 5637732Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.Type: GrantFiled: February 6, 1995Date of Patent: June 10, 1997Assignee: Florida State UniversityInventors: Robert A. Holton, Carmen Somoza, Hyeong B. Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase Smith, Feng Liang, Krishna Murthi
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Patent number: 5618952Abstract: Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.Type: GrantFiled: February 6, 1995Date of Patent: April 8, 1997Assignee: Florida State UniversityInventors: Robert A. Holton, Carmen Somoza, Hyeong B. Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase Smith, Feng Liang, Krishna Murthi
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Patent number: 5618946Abstract: The present invention relates to novel 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates which may be used to prepare a final anti-thrombotic, anti-vasospastic product, and to methods for preparing the same.Type: GrantFiled: February 29, 1996Date of Patent: April 8, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
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Patent number: 5541344Abstract: The present invention is directed to intermediates of the formula ##STR1## which are useful in a process for the preparation of aminoazanoradamanatanes.Type: GrantFiled: May 19, 1995Date of Patent: July 30, 1996Assignee: G. D. Searle & Co.Inventors: Daniel P. Becker, Daniel L. Flynn, Alan E. Moormann, Clara I. Villamil
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Patent number: 5512690Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##Type: GrantFiled: September 14, 1995Date of Patent: April 30, 1996Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
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Patent number: 5510373Abstract: This invention relates to certain hydroxy derivatives of 3,4-dihydro-2,5,7,8-tetraalkyl-2H-1-benzopyran-2-carboxylic acids and the lactones thereof, to the processes and intermediates useful for their preparation and to their use as free radical scavengers useful in the treatment of tissue damage implicated with free oxygen radicals.Type: GrantFiled: October 5, 1994Date of Patent: April 23, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: J. Martin Grisar, Margaret A. Petty, Frank Bolkenius
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Patent number: 5508445Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##Type: GrantFiled: December 15, 1994Date of Patent: April 16, 1996Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
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Patent number: 5405972Abstract: Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.Type: GrantFiled: January 27, 1994Date of Patent: April 11, 1995Assignee: Florida State UniversityInventors: Robert A. Holton, Carmen Somoza, Hyeong B. Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase Smith, Feng Liang, Krishna Murthi
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Patent number: 5403940Abstract: The invention relates to a new vitamin D compound, substituted in the 18-position with an alkyl group, a hydroxy group, an alkoxy group, an alkenyl group, an alkynyl group, a fluorinated alkyl group or a fluorinated alkenyl group.The invention also relates to a method of preparing said vitamin D compound and to a lactone and a hydrindane intermediate.Type: GrantFiled: January 12, 1994Date of Patent: April 4, 1995Assignee: Duphar International Research B.V.Inventors: Maria J. Valles, Jose L. Mascarenas, Antonio Mourino, Sebastianus J. Halkes, Jan Zorgdrager
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Patent number: 5332840Abstract: A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic - anti-vasospastic compounds. Novel intermediates are also provided.Type: GrantFiled: May 27, 1993Date of Patent: July 26, 1994Assignee: Bristol-Myers Squibb CompanyInventors: Sharon D. Real, David R. Kronenthal
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Patent number: 5179092Abstract: A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 30, 1991Date of Patent: January 12, 1993Assignee: Suntory LimitedInventors: Toshio Tatsuoka, Kenji Suzuki, Fumio Satoh, Seiji Miyano, Kunihiro Sumoto
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Patent number: 5136050Abstract: Novel substituted lactones of amino acids in all their possible stereoisomeric forms or mixtures thereof of the formula ##STR1## wherein A is a hydrocarbon chain of 1 to 10 chain members containing one or more heteroatoms and one or more unsaturations and the chain members being a mono- or polycyclic system or comprises a system of spiro or endo type and may contain one or more chiral atoms or the lactone copula can present a supplementary chirality due to the asymetric spatial configuration of the molecule make up and R is selected from the group consisting of ##STR2## wherein Z is the organic remainder of an amino acid of the formula ##STR3## Y is derived from a primary, secondary or tertiary alcohol of the formula Y-OH and B is the remainder of a heterocycle amino acid of 3 to 6 carbon atoms of the formula ##STR4## and their preparation and their use for the resolution of amino acids.Type: GrantFiled: February 11, 1988Date of Patent: August 4, 1992Assignee: Roussel UclafInventors: Jacques Martel, Jean Tessier, Andre Teche
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Patent number: 5013851Abstract: There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of the intermediates into known intermediates which are readily converted into podophyllotoxin and related compounds.Type: GrantFiled: February 1, 1989Date of Patent: May 7, 1991Assignee: Bristol-Myers CompanyInventors: Takushi Kaneko, Henry S. L. Wong
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Patent number: 4857661Abstract: Alkyl substituted or unsubstituted, bicyclic keto acids may be prepared by cyclizing unsaturated, cyclic dicarboxylic acid anhydrides in the presence of a strong Bronsted acid catalyst. The products may be useful as corrosion inhibitors in alcohol fuels and as intermediates in petroleum, pharmaceutical and additive manufacture.Type: GrantFiled: January 23, 1986Date of Patent: August 15, 1989Assignee: Texaco Inc.Inventors: Rodney L. Sung, Benjamin J. Kaufman
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Patent number: 4855460Abstract: A process for the preparation of perfluoroalkylated ketones and/or perfluoroalkylated alcohols, comprising the step of contacting a perfluoroalkyl iodide or perfluoroalkyl bromide with an acid anhydride, in the presence of a metal chosen from zinc and cadmium.Type: GrantFiled: July 11, 1988Date of Patent: August 8, 1989Assignee: Rhone-Poulenc ChimieInventors: Marc Tordeux, Claude Wakselman, Catherine Francese
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Patent number: 4841074Abstract: This invention discloses intermediates and a process for the preparation of 6-desmethyl-6-carboxy derivatives of lovastatin and analogs thereof at the 9-acyl side chain.Type: GrantFiled: December 11, 1987Date of Patent: June 20, 1989Assignee: Merck & Co., Inc.Inventors: Ta J. Lee, William F. Hoffman
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Patent number: 4788299Abstract: New ketolactones of the formula I ##STR1## wherein R.sup.1 is H, alkyl having 1-6 C atoms or aryl having 6-14 C atoms andR.sup.2 and R.sup.3 together are an O atom or together are a bond,and salts thereof,can be used as intermediate products in the preparation of prostaglandin derivatives.Type: GrantFiled: June 17, 1987Date of Patent: November 29, 1988Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventor: Bernhard Riefling
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Patent number: 4783222Abstract: A surface treatment composition for glass fibers comprising an aqueous solution or emulsion of an organosilane which contains at least one isoimido group. The organosilane with the highest adhesion promotion is N-2-(isomaleimodo)aminoethyl-3-aminopropyl-trimethylsilane.Type: GrantFiled: November 17, 1987Date of Patent: November 8, 1988Assignee: International Business Machines CorporationInventor: Frank Druschke
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Patent number: 4734512Abstract: There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of the intermediates into known intermediates which are readily converted into podophyllotoxin and related compounds.Type: GrantFiled: December 5, 1985Date of Patent: March 29, 1988Assignee: Bristol-Myers CompanyInventors: Takushi Kaneko, Henry S. L. Wong
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Patent number: RE41580Abstract: A novel lactone-containing compound is provided as well as a polymer comprising units of the compound. The polymer is used as a base resin to formulate a resist composition having a high sensitivity, resolution and etching resistance.Type: GrantFiled: September 23, 2005Date of Patent: August 24, 2010Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Koji Hasegawa, Tsunehiro Nishi, Takeshi Kinsho, Jun Hatakeyama, Osamu Watanabe