Chalcogen Attached Indirectly To The Lactone Ring By Acyclic Nonionic Bonding Patents (Class 549/305)
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Patent number: 7026351Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.Type: GrantFiled: March 20, 2003Date of Patent: April 11, 2006Assignee: Xenoport, Inc.Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
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Patent number: 6992197Abstract: A novel monomer compound having a lactone moiety of the present invention can be converted into polymers usable as resist materials with excellent properties, etc., and an alcohol compound having a lactone moiety of the invention is useful as a material for the monomer compound. The compounds are represented by the following general formula [1]: wherein one of R1 and R2 represents a hydrogen atom, an acryloyl group, or a methacryloyl group, and the other represents an alkyl group; R3 and R4 independently represent a hydrogen atom or an alkyl group; R5 and R6 both represent a hydrogen atom or are combined to form a methylene chain that may have an alkyl group; and R7 and R8 independently represent a hydrogen atom or a methyl group.Type: GrantFiled: June 10, 2004Date of Patent: January 31, 2006Assignee: Takasago International CorporationInventors: Junji Nakamura, Shigetaka Numasawa, Hiroyuki Kenmochi, Yoji Hori
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Patent number: 6888009Abstract: 5-carboxyphthalide is obtained with very high purity and in high yields by a convenient process comprising reaction of terephthalic acid with paraformaldehyde HO(CH2)nH in oleum.Type: GrantFiled: May 6, 2002Date of Patent: May 3, 2005Assignee: H. Lundbeck A/SInventors: Hans Petersen, Poul Dahlberg Nielsen
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Patent number: 6868215Abstract: A dye thin film containing a dye compound represented by the general formula (I), an optical switch, an optical distributor, an optical modulator and an optical switch array having the dye thin film, as well as a method for producing a dye thin film are provided. The method includes the step of coating the solution of the dye compound on a substrate: where R1 and R2 may be identical or different from each other and each represents, respectively, a linear alkyl group or a branched alkyl group, the dye thin film having high thermal stability, having intense absorption at approximately 1.3 ?m and having ultrafast response characteristic.Type: GrantFiled: April 25, 2003Date of Patent: March 15, 2005Assignee: Fuji Xerox Co., Ltd.Inventors: Minquan Tian, Makoto Furuki, Satoshi Tatsuura, Yasuhiro Sato, Izumi Iwasa, Lyong Sun Pu
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Patent number: 6864279Abstract: This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.Type: GrantFiled: April 24, 2002Date of Patent: March 8, 2005Assignee: Aryx TherapeuticsInventors: Pascal Druzgala, Xiaoming Zhang, Jürg Pfister
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Patent number: 6825363Abstract: A dibenzofuranonylium methylate compound represented by the following formula (I), having maximum absorption wavelength of over 1 &mgr;m, high thermal stability and good solubility in organic solvents, and a production method thereof are provided: where R1 and R2 may be identical or different from each other and each represents a linear alkyl group or a branched alkyl group, respectively.Type: GrantFiled: April 2, 2003Date of Patent: November 30, 2004Assignee: Fuji Xerox Co., Ltd.Inventors: Minquan Tian, Makoto Furuki, Lyong Sun Pu, Yasuhiro Sato, Izumi Iwasa, Satoshi Tatsuura
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Patent number: 6809208Abstract: The invention describes novel compounds of the formula (I) wherein the general symbols are as defined in claim (1) and R1 is an aromatic radical with electron withdrawing substituents, as stabilizers for protecting organic materials, in particular polymers and lubricants, against oxidative, thermal or light-induced degradation and as scavengers for oxidized developer in color photographic material.Type: GrantFiled: August 12, 2002Date of Patent: October 26, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Michael Tinkl, Oliver Dosenbach, Peter Nesvadba, Martin Wolff, Bruno Rotzinger, Dietmar Mäder
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Patent number: 6780887Abstract: The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating and/or preventing pathologies associated with ischemia or with mitochondrial deficiencies.Type: GrantFiled: July 30, 2002Date of Patent: August 24, 2004Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Carine Michiels, Martine Redon, Jose Remacle
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Patent number: 6762327Abstract: A safe and effective process for the oxidation of a primary or secondary alcohol to the corresponding aldehyde or ketone via the reaction of said alcohol with an anhydride solution of a 1,1,1-tri(C2-C4 alkanoyloxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, and a composition useful in this process.Type: GrantFiled: April 3, 2003Date of Patent: July 13, 2004Assignee: WyethInventors: Ugo Chiacchio, Antonio Rescifina, Giuseppe Miraglia, Mariangela Magnano, Paola Di Raimondo
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Publication number: 20040063882Abstract: The (meth)acrylate of the present invention is represented by the following formula (1). The (meth)acrylate can be produced by first producing a lactone by reducing an addition product obtained by the Diels-Alder reaction between 1,3-diene and maleic anhydride, and then hydrating the lactone to produce an alcohol followed by (meth)acrylation of the alcohol. A polymer produced by (co)polymerizing a monomer composition comprising the (meth)acrylate of the present invention is excellent in transparency, dry etching resistance, and solubility in organic solvents, and so it is preferably used as a resin for a chemically amplified resist composition.Type: ApplicationFiled: June 5, 2003Publication date: April 1, 2004Inventors: Yoshihiro Kamon, Tadayuki Fujiwara, Hideaki Kuwano, Hikaru Momose, Atsushi Koizumi
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Patent number: 6703516Abstract: There is described a process for the preparation of 5-carboxy phthalide, which comprises adding terephthalic acid to fuming sulfuric acid containing at least 20% of SO3, then adding formaldehyde to the mixture, heating the mixture at a temperature of 120-145° C. and isolating 5-carboxyphthalide from the reaction mixture.Type: GrantFiled: August 23, 2002Date of Patent: March 9, 2004Assignee: Infosint SAInventors: Leone Dall'Asta, Umberto Casazza, Giovanni Cotticelli
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Publication number: 20030149294Abstract: Disclosed is a novel process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process.Type: ApplicationFiled: October 25, 2002Publication date: August 7, 2003Inventors: Arie Gutman, Gennadiy Nisnevich, Marina Etinger, Igor Zaltzman, Lev Judovich, Boris Pertsikov
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Patent number: 6586606Abstract: The instant invention discloses a process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises hydrolyzing a compound of formula V wherein the general symbols are as defined in claim 1, in an aqueous solvent in the presence of an acid. The compounds of the formula V are new and useful as stabilizers for protecting organic materials, in particular polymers and lubricants, against oxidative, thermal or light-induced degradation.Type: GrantFiled: July 5, 2001Date of Patent: July 1, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Michèle Gerster, Paul Dubs
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Patent number: 6515147Abstract: A product corresponding to formula (I) or its ketonic tautomer form (II) which is 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one, a process for the preparation and use of the product corresponding to formula (I) or its tautomeric form (II), a process for the preparation and use, particularly for the production of synthesis intermediates.Type: GrantFiled: January 17, 2001Date of Patent: February 4, 2003Assignee: Clariant France S.A.Inventors: Alain Schouteeten, Françoise Mordacq
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Publication number: 20030013758Abstract: This invention describes the novel use of alkyl, alkoxyl, halogenyl, or hydroxy substituted dicinnamoylquinides as therapeutic agents for enhancing adenosine levels in the brain and peripheral organs. These agents are particularly useful in treating human diseases or conditions that benefit from acute or chronic elevated levels of adenosine, such as reperfusion injury, coronary or cerebral ischemia, coronary vasoconstriction, paroxysmal supraventricular tachycardia, hypertension, wound healing, diabetes, inflammation, or sleep disturbances. They can also be used to protect normal cells from chemotoxicity in patients undergoing cancer therapy, and reverse the behavioral effects of caffeine intake.Type: ApplicationFiled: May 10, 2002Publication date: January 16, 2003Inventors: Tomas de Paulis, David M. Lovinger, Peter R. Martin
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Patent number: 6500962Abstract: The present invention relates to a method for producing an &agr;-methylene-&ggr;-butyrolactone which is one of basic structures often shown in drugs such as an anti-cancer agent by reacting an alene compound having an aldehyde or ketone group with carbon monoxide via cyclization in a single step in the presence of a catalyst containing ruthenium, thereby improving total yield of the entire reaction and achieving effects of cost reduction.Type: GrantFiled: March 15, 2002Date of Patent: December 31, 2002Assignee: Sungkyunkwan UniversityInventors: Suk-Koo Kang, Kwang-Jin Kim
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Patent number: 6482959Abstract: A process for the preparation of &agr;,&bgr;-unsaturated alcohols of general formula (I), wherein R means an alkyl group of 1-4 carbon atoms, or benzoyloxy group optionally substituted with a phenyl group; R1 means a hydrogen atom or an alkyl group of 1-4 carbon atoms, R2 means a hydrogen atom or an alkyl group of 1-4 carbon atoms; R3 means an alkyl group of 1-6 carbon atoms optionally substituted by phenyl group or cycloalkyl group of 5-7 carbon atoms; or a phenoxy group optionally substituted by a halogen atom, or a cycloalkyl group of 5-7 carbon atoms; R4 means a hydrogen atom or a halogen atom whereby at &agr;,&bgr;-unsaturated ketones of general formula (II) wherein the meanings of R, R1, R2, R3, and R4 are as given above—is diastereoselectively reduced with a borohydride type compound in an aprotic solvent, in the presence of an inorganic substance dissolublein the reaction mixture and having particle size from 0.Type: GrantFiled: June 27, 2000Date of Patent: November 19, 2002Assignee: Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt.Inventors: Kardos Zsuzsanna Baloghne, Nandor Benno, Povarny Magdonla Beresne, Gyula Dalmadi, Katalin Ebinger, Laszlo Forro, Geza Galambos, Felix Hajdu, Istvan Hermecz, Geza Lukacs, Karoly Mozsolits, Szigeti Katalin Polikne, Judit Sebestyen, Tobor Szabo, Zoltan Szeverenyi, Ervin Vajda, Gabor Vankai, Pal Vofely
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Patent number: 6462074Abstract: The present invention relates to novel substituted (&agr;,&bgr;-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.Type: GrantFiled: July 14, 2000Date of Patent: October 8, 2002Assignee: Bayer AktiengesellschaftInventors: Andreas Stolle, Horst-Peter Antonicek, Stephen Lensky, Arnd Voerste, Thomas Müller, Jörg Baumgarten, Karsten von dem Bruch, Gerhard Müller, Udo Stropp, Ervin Horváth, Jean-Marie-Viktor de Vry, Rudy Schreiber
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Patent number: 6458973Abstract: There is described a process for the preparation of 5-carboxy phthalide, which comprises adding terephthalic acid to fuming sulfuric acid containing at least 20% of SO3, then adding formaldehyde to the mixture, heating the mixture at a temperature of 120-145° C. and isolating 5-carboxyphthalide from the reaction mixture.Type: GrantFiled: October 17, 2000Date of Patent: October 1, 2002Assignee: Norpharma S.p.A.Inventors: Leone Dall'Asta, Umberto Casazza, Giovanni Cotticelli
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Patent number: 6429203Abstract: Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described.Type: GrantFiled: April 18, 2000Date of Patent: August 6, 2002Assignee: International Phytochemistry Research Labs, Ltd.Inventors: Tattym E. Shaikenov, Sergazy M. Adekenov
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Patent number: 6403813Abstract: 5-carboxyphthalide is obtained with very high purity and in high yields by a convenient process comprising reaction of terephthalic acid with paraformaldehyde HO(CH2)nH in oleum.Type: GrantFiled: October 19, 2000Date of Patent: June 11, 2002Assignee: H. Lundbeck A/SInventors: Hans Petersen, Poul Dahlberg Nielsen
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Patent number: 6376535Abstract: The present invention relates to oxygen-containing heterocyclic compounds represented by the following formula (I): wherein m represents an integer of 0 to 4; R1, R2, R3 and R4 independently represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R5 represents substituted or unsubstituted lower alkoxy etc.; R6 represents a hydrogen atom etc.; and Y represents the following formula (II): wherein R9 represents cyano etc., R10 represents a hydrogen atom etc., R11 represents carboxy etc., and R12 represents a hydrogen atom etc.; and the like; or pharmaceutically acceptable salts thereof.Type: GrantFiled: March 1, 2001Date of Patent: April 23, 2002Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Etsuo Ohshima, Koji Yanagawa, Haruhiko Manabe, Ichiro Miki, Yoshiaki Masuda
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Patent number: 6376539Abstract: The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, cranial cerebral trauma, states of pain or CNS-mediated spasms.Type: GrantFiled: July 14, 2000Date of Patent: April 23, 2002Assignee: Bayer AktiengesellschaftInventors: Andreas Stolle, Horst-Peter Antonicek, Stephen Lensky, Arnd Voerste, Thomas Müller, Jörg Baumgarten, Karsten von dem Bruch, Gerhard Müller, Udo Stropp, Ervin Horváth, Jean-Marie-Viktor de Vry, Rudy Schreiber
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Publication number: 20010012900Abstract: A product corresponding to formula (I) or its ketonic tautomer form (II) 1Type: ApplicationFiled: January 17, 2001Publication date: August 9, 2001Applicant: Clariant (France)Inventors: Alain Schouteeten, Francoise Mordacq
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Patent number: 6268394Abstract: Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described.Type: GrantFiled: July 26, 1999Date of Patent: July 31, 2001Assignee: International Phytochemistry Research Labs, Ltd.Inventors: Tattym E. Shaikenov, Sergazy M. Adekenov
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Patent number: 6207841Abstract: A bisphenol derivative represented by the following formula and a manufacturing method thereof are disclosed. where R is a lower alkyl group, tetrahydropyranyl, methoxymethyl or trialkylsilyl group, and the benzene rings in the formula may be substituted by a lower alkyl group.Type: GrantFiled: August 22, 1994Date of Patent: March 27, 2001Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Fujio Yagihasi, Minoru Takamizawa
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Patent number: 6153645Abstract: Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as antimicrobial agents.Type: GrantFiled: September 10, 1999Date of Patent: November 28, 2000Assignee: Cubist Pharmaceuticals, Inc.Inventors: John Finn, Xiang Yang Yu, Zhongguo Wang, Jason Hill, Dennis Keith, Paul Gallant, Philip Wendler
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Patent number: 6100292Abstract: This invention relates to ketones represented by the following formula ##STR1## and to drugs in which such a ketone or pharmacologically acceptable salt thereof is an effective component.The ketones of the present invention encourage the production of platelets, red blood cells, white blood cells and the like, and can be used to prevent or treat cytopaenia brought about by cancer chemotherapy, radiotherapy, bone marrow transplantation and drug therapy, or by immunological abnormality or anaemia, and the like.Type: GrantFiled: May 25, 1999Date of Patent: August 8, 2000Assignee: Toray Industries, Inc.Inventors: Tsuyoshi Matsumoto, Hideki Kawai, Kiyoshi Okano, Katsuyuki Mori, Yasumoto Adachi
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Patent number: 6051565Abstract: Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described.Type: GrantFiled: February 25, 1998Date of Patent: April 18, 2000Assignee: International Phytochemistry Research Labs, Ltd.Inventors: Tattym E. Shaikenov, Sergazy M. Adekenov
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Patent number: 6048882Abstract: Hepatic diseases can be prevented or treated by administering an isoprenylamine derivative represented by the general formula (II) ##STR1## [wherein n represents an integer of 4-12, m represents an integer of 0-3, Ar represents a phenyl group, a furyl group, a thienyl group or a pyridyl group, said group being optionally substituted with one or more of an alkyl group of 1-4 carbon atoms, and alkoxy group of 1-4 carbon atoms, a methylenedioxy group, a hydroxy group or a halogen atom, and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms] or a pharmacologically acceptable salt thereof at a daily dose of 0.01-500 .mu.g/kg.A lipid emulsion of the compound (II) is particularly useful and can be administered at a remarkably lowered dose as compared with other pharmaceutical preparations.Type: GrantFiled: August 8, 1997Date of Patent: April 11, 2000Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Tatsuya Ohwaki, Masako Yamada, Hiroyuki Yamazaki, Hitoshi Inoue, Yoshiyuki Tahara, Shigeo Kawase
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Patent number: 6028204Abstract: The disclosure is a process for preparing a phthalide of the general formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently of the others hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, by catalytic hydrogenation of a phthalic anhydride of the general formula II ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each as defined above, in a solvent, which comprises using said phthalide I, the reaction product of the catalytic hydrogenation, as solvent.Type: GrantFiled: December 16, 1998Date of Patent: February 22, 2000Assignee: BASF AktiengesellschaftInventors: Klemens Massonne, Rainer Becker, Wolfgang Reif, Horst Neuhauser, Andreas Gieseler, Klaus Mundinger
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Patent number: 6020501Abstract: The disclosure is a process for preparing a phthalide of the general formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently of the others hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, by hydrogenation of a phthalic anhydride of the general formula II ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each as defined above, with the aid of a hydrogenation catalyst, which comprises performing the hydrogenation with the aid of a nickel catalyst doped with metals of subgroup 1, subgroup 6 and/or subgroup 7 of the Periodic Table.Type: GrantFiled: January 7, 1999Date of Patent: February 1, 2000Assignee: BASF AktiengesellschaftInventors: Klemens Massonne, Rainer Becker, Wolfgang Reif, Joachim Wulff-Doring
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Patent number: 5900492Abstract: A method for resolving optically impure 3-oxa-2-oxobicyclo?3.1.0!hexane-1-carboxylic acid esters. A method is provided for producing a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid.N-benzyl-.alpha.-phenylethylamine diastereomer salt. An enantiomer of N-benzyl-.alpha.-phenylethylamine is reacted with a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid to produce a precipitate that is enriched in one diastereomer of the salt. After isolating the optically active salt, the N-benzyl-.alpha.-phenylethylamine may be separated to produce the corresponding 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid. Under acidic conditions, the carboxylic acid and hydroxyl groups undergo ring closure to afford the optically active 3-oxa-2-oxobicyclo?3.1.0!hexane-1-carboxylic acid ester.Type: GrantFiled: December 2, 1997Date of Patent: May 4, 1999Assignee: Ajinomoto Co., Inc.Inventors: Katsutoshi Sakata, Takashi Tsuji, Noriyasu Kataoka, Masanobu Yatagai
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Process for the preparation of 3-(.alpha.-methoxy)methylenebenzofuranones and intermediates therefor
Patent number: 5760250Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl, and processes for preparing the same.Type: GrantFiled: June 7, 1995Date of Patent: June 2, 1998Assignee: Zeneca LimitedInventors: John David Jones, Gareth Andrew DeBoos, Paul Wilkinson, Brian Geoffrey Cox, Jan Michael Fielden -
Patent number: 5717098Abstract: A process for the preparation of a .gamma.-lactone of the formula ##STR1## which can be used to produce a single enantiomer of aminoazanoradamantane which is coupled to aromatic acid moieties to produce compounds useful as 5-HT agonists or antagonists.Type: GrantFiled: July 22, 1996Date of Patent: February 10, 1998Assignee: G. D. Searle & Co.Inventors: Daniel Paul Becker, Daniel Lee Flynn, Alan Edward Moormann, Clara Ines Villamil
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Patent number: 5616732Abstract: A difluoroprostacyclin of the following formula (V), its lower alkanol ester or its pharmaceutically acceptable salt: ##STR1## wherein A is an ethylene group, a vinylene group or an ethynylene group, R is a substituted or unsubstituted C.sub.1-10 alkyl group, a substituted or unsubstituted C.sub.1-10 alkenyl group, a substituted or unsubstituted C.sub.1-10 alkynyl group, a substituted or unsubstituted C.sub.3-8 cycloalkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryloxy group, Q is a substituted or unsubstituted C.sub.1-10 alkyl group, a substituted or unsubstituted C.sub.1-10 alkenyl group, a substituted or unsubstituted C.sub.1-10 alkynyl group, a substituted or unsubstituted C.sub.3-8 cycloalkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group.Type: GrantFiled: February 13, 1996Date of Patent: April 1, 1997Assignee: Asahi Glass Company Ltd.Inventors: Yasushi Matsumura, Takashi Nakano, Mayumi Makino, Yoshitomi Morizawa
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Patent number: 5606101Abstract: A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## and intermediates thereof.Type: GrantFiled: October 6, 1995Date of Patent: February 25, 1997Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takashi Nomoto, Masahiro Hayashi, Jun Shibata, Yoshikazu Iwasawa, Morihiro Mitsuya, Yoshiaki IIda, Katsumasa Nonoshita, Yasufumi Nagata
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Patent number: 5599949Abstract: A bisphenol derivative represented by the following formula and a manufacturing method thereof are disclosed: ##STR1## where R is a lower alkyl group, tetrahydropyranyl, methoxymethyl or trialkylsilyl group, and the benzene rings in the formula may be substituted by a lower alkyl group.Type: GrantFiled: June 5, 1995Date of Patent: February 4, 1997Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Fujio Yagihasi, Minoru Takamizawa
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Patent number: 5597943Abstract: The present invention relates to the new thielocin derivatives, which exhibit phospholipase A.sub.2 inhibitory activity of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently hydrogen, lower alkyl, lower alkoxy, hydroxy, or halogen;E.sub.1 and E.sub.2 are independently hydrogen, or an ester residue;m and n are independently an integer of 0 to 4;--Y-- is a bivalent group which is selected from the group consisiting of the following radicals: ##STR2## or the salts thereof.Type: GrantFiled: December 13, 1995Date of Patent: January 28, 1997Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Shigeru Matsutani, Tadashi Yoshida, Kazushige Tanaka, Yasuhiko Fujii, Kazuhiro Shirahase
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Patent number: 5585501Abstract: A method for reduction of an allyl alcohol-type compound, specific to its allylic hydroxyl group, being carried out without any side reactions such as reduction of other portions of the compound or allylic rearrangement, which comprises treating the compound with trialkylsilane in the presence of AlX.sub.3, wherein X refers to a halogen atom.Type: GrantFiled: May 30, 1995Date of Patent: December 17, 1996Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Takaharu Matsuura, Yoshinori Hamada, Isamu Yamada, Teruo Sakata, Kimio Takahashi, Morio Kishi
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Patent number: 5556994Abstract: A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. In addition another aspect of the invention provides (3-oxa-2-oxobicyclo[3,1,0]hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I) from this compound by replacing the hydroxyl group of the compound with a leaving group followed by reaction with a purine derivative.Type: GrantFiled: March 30, 1995Date of Patent: September 17, 1996Assignee: Ajinomoto Co., Inc.Inventors: Tomoyuki Onishi, Takashi Tsuji, Toshihiro Matsuzawa
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Patent number: 5541344Abstract: The present invention is directed to intermediates of the formula ##STR1## which are useful in a process for the preparation of aminoazanoradamanatanes.Type: GrantFiled: May 19, 1995Date of Patent: July 30, 1996Assignee: G. D. Searle & Co.Inventors: Daniel P. Becker, Daniel L. Flynn, Alan E. Moormann, Clara I. Villamil
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Patent number: 5508446Abstract: A method for producing an alkyl 3-phthalidylideneacetate has the step of treating phthalic anhydride with a monoalkyl malonate or a salt thereof having the following formula:MOCO--CH.sub.2 --COOR,wherein M represents a hydrogen atom, K, Na, Li, or NH.sub.4, and R represents a lower alkyl group having 1 to 5 carbon atoms. By using the above method, the desired alkyl 3-phthalidylideneacetate can be obtained at a high yield.Type: GrantFiled: October 3, 1994Date of Patent: April 16, 1996Assignee: Sumika Fine Chemicals Co., Ltd.Inventor: Taketo Hayashi
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Patent number: 5488117Abstract: Compounds of the formula (1) ##STR1## in which R.sub.2, R.sub.3, R.sub.4 and R.sub.5 independently of one another, are hydrogen, C.sub.1 -C.sub.25 alkyl, C.sub.7 -C.sub.9 phenylalkyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted phenyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted C.sub.5 -C.sub.8 cycloalkyl; C.sub.1 -C.sub.18 alkoxy, hydroxyl, C.sub.1 -C.sub.25 alkanoyloxy, C.sub.3 -C.sub.25 alkenoyloxy, C.sub.3 -C.sub.25 alkanoyloxy which is interrupted by oxygen, sulfur or >N--R.sub.16 ; C.sub.6 -C.sub.9 cycloalkylcarbonyloxy, benzoyloxy or C.sub.1 -C.sub.12 alkyl-substituted benzoyloxy, where R.sub.16 is hydrogen or C.sub.1 -C.sub.8 alkyl, or, furthermore, the radicals R.sub.2 and R.sub.3 or the radicals R.sub.4 and R.sub.5 together with the carbon atoms to which they are bound form a phenyl ring, R.sub.4 is additionally --(CH.sub.2).sub.n --COR.sub.11, in which n is 0, 1 or 2, R.sub.11 is hydroxyl, ##STR2## R.sub.14 and R.sub.15, independently of one another, are hydrogen or C.sub.1 -C.Type: GrantFiled: July 26, 1994Date of Patent: January 30, 1996Assignee: Ciba-Geigy CorporationInventor: Peter Nesvadba
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Patent number: 5468880Abstract: Improvement in the technique of synthesizing prostaglandins, particularly those having at least one halogen atom at the 16- or 17-position, which comprises introducing a .omega. chain into the aldehyde thereby to enable considerable yield improvement in the production of .alpha.,.beta.-unsaturated ketones, and which does not involve hydrogen generation and can insure safe operation.A method of producing .alpha.,.beta.-unsaturated ketones by reacting aldehyde with 2-oxoalkyl phosphonate, wherein the reaction was carried out under the presence of a base and a zinc compound.Type: GrantFiled: May 31, 1994Date of Patent: November 21, 1995Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Ryuji Ueno, Tomio Oda
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Patent number: 5459264Abstract: A method for reducing an .alpha.,.beta.-unsaturated ketone of the present invention includes the step of treating the .alpha.,.beta.-unsaturated ketone with a silyl compound in the presence of a Lewis acid and alcohol to selectively reduce the carbonyl group of the .alpha.,.beta.-unsaturated ketone. According to this method, a deoxy-compound can be obtained from the .alpha.,.beta.-unsaturated ketone by selectively reducing the carbonyl group without reducing an .alpha.,.beta.-unsaturated bond.Type: GrantFiled: December 17, 1993Date of Patent: October 17, 1995Assignee: Shionogi Seiyaku Kabushiki KaishaInventors: Mitsuru Imuta, Makoto Kobayashi, Teruo Iizuka
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Patent number: 5444072Abstract: The disclosed 6-substituted derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.Type: GrantFiled: February 18, 1994Date of Patent: August 22, 1995Assignee: Syntex (U.S.A.) Inc.Inventors: John W. Patterson, David Morgans, Jr., David B. Smith, Francisco X. Talamas, Dean R. Artis, Alicia Cervantes, Todd R. Elworthy, Mario Fernandez, Fidencio Franco, Ronald C. Hawley, Teresa Lara, David G. Loughhead, Peter H. Nelson, Eric B. Sjogren, Alejandra Trejo, Ann M. Waltos, Robert J. Weikert
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Patent number: 5428177Abstract: Novel compounds of formula (1) ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkaryl, R.sub.2 to R.sub.5 are independently hydrogen, chloro, alkyl phenylalkyl, aryl, cycloalkyl, alkoxy, alkylthio, hydroxy, amino or substituted amino, R.sub.6 is hydrogen, R.sub.7 and R.sub.8 are hydrogen or alkyl, R.sub.9 and R.sub.9 ' are hydrogen, alkyl or phenyl, and R.sub.10 is hydrogen or alkyl, are disclosed as stabilisers for protecting organic materials against thermal, oxidative or light-induced degradation.Type: GrantFiled: September 20, 1993Date of Patent: June 27, 1995Assignee: Ciba-Geigy CorporationInventor: Peter Nesvadba
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Patent number: 5428162Abstract: Novel compounds of the formula (1), ##STR1## in which R.sub.1 is hydrogen or acyl, R.sub.2 to R.sub.5 are independently hydrogen, chloro, alkyl phenylalkyl, aryl, cycloalkyl, alkoxy, alkylthio, hydroxy, amino or substituted amino, R.sub.6 is hydrogen, R.sub.7 to R.sub.10 are independently hydrogen, alkyl or alkoxy, R.sub.17 or R.sub.19 is hydrogen or alkyl, and R.sub.18 is hydrogen, alkyl, aralkyl or aryl, are described for use as stabilizers for organic materials against thermal, oxidative or light-induced degradation.Type: GrantFiled: September 20, 1993Date of Patent: June 27, 1995Assignee: Ciba-Geigy CorporationInventor: Peter Nesvadba
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Patent number: 5384411Abstract: Disclosed are pH dyes containing a suitable compatible substituent which permits binding of the dye to a solid support. Also disclosed are methods for synthesizing such dyes prior to their coupling to the solid supports.Type: GrantFiled: June 20, 1991Date of Patent: January 24, 1995Assignee: Hewlett-Packard CompanyInventors: Karla M. Robotti, Carl A. Myerholtz