Plural Double Bonds Between Ring Members Of The Hetero Ring Patents (Class 549/505)
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Publication number: 20110313178Abstract: The present invention discloses a process for producing small molecular weight organic compounds from carbonaceous material comprising a step of contacting the carbonaceous material with carbon monoxide (CO) and steam in presence of a shift catalyst at a predetermined temperature and pressure.Type: ApplicationFiled: July 31, 2008Publication date: December 22, 2011Applicant: NAGARJUNA ENERGY PRIVATE LIMITEDInventors: Manoj Kumar Sarkar, Dhurjati Prasad Chakrabarti, Dhruba Sarkar, Banibrata Pandey
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Publication number: 20110245554Abstract: Disclosed herein is a method of generating hydrogen from a bio-oil, comprising hydrogenating a water-soluble fraction of the bio-oil with hydrogen in the presence of a hydrogenation catalyst, and reforming the water-soluble fraction by aqueous-phase reforming in the presence of a reforming catalyst, wherein hydrogen is generated by the reforming, and the amount of hydrogen generated is greater than that consumed by the hydrogenating. The method can further comprise hydrocracking or hydrotreating a lignin fraction of the bio-oil with hydrogen in the presence of a hydrocracking catalyst wherein the lignin fraction of bio-oil is obtained as a water-insoluble fraction from aqueous extraction of bio-oil. The hydrogen used in the hydrogenating and in the hydrocracking or hydrotreating can be generated by reforming the water-soluble fraction of bio-oil.Type: ApplicationFiled: September 18, 2009Publication date: October 6, 2011Applicant: UNIVERSITY OF MASSACHUSETTSInventors: George W. Huber, Tushar P. Vispute, Kamalakanta Routray
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Patent number: 8017772Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.Type: GrantFiled: September 11, 2009Date of Patent: September 13, 2011Assignee: Gruenenthal GmbHInventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
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Patent number: 8013187Abstract: 2-cyclopenten-1-one oxime derivatives represented by Formula (I), or pharmaceutically acceptable salts thereof inhibit the production of TNF-? or PDE4, and therefore show therapeutic effect in inflammatory or immunological disorders mediated through TNF-? or PDE4.Type: GrantFiled: November 30, 2005Date of Patent: September 6, 2011Assignee: Amorepacific CorporationInventors: Yeonjoon Kim, Sun-Young Kim, Jung Sun Hwang, Kyoung Min Lim, Miyoung Park, Hyun Ju Koh, Sa-Yong Hong, Song Seok Shin, Jin Kyu Choi, Joo-Hyun Moh, Shin Chung, Byoung Young Woo, Sung Il Kim
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Patent number: 8012983Abstract: Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.Type: GrantFiled: May 6, 2009Date of Patent: September 6, 2011Assignee: Galapagos NVInventors: Martin James Inglis Andrews, Mark Stuart Chambers, Hervé Van De Poël, Grégory Louis Joseph Bar
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Publication number: 20110213112Abstract: Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan.Type: ApplicationFiled: May 6, 2011Publication date: September 1, 2011Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Vladimir Grushin, WALTER PARTENHEIMER, LEO E. MANZER
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Publication number: 20110201832Abstract: A process is provided for the synthesis of furan and related compounds by vapor phase decarbonylation of furfural and derivatives, using a palladium/alumina catalyst that has been promoted with an alkali carbonate. Catalyst lifetime is improved. The catalyst can be regenerated in situ by feeding a mixture of air and steam, with a composition of between about 2% and about 40% air, to the catalyst bed at a temperature between about 300° C. and about 500° C.Type: ApplicationFiled: December 8, 2009Publication date: August 18, 2011Inventors: Ke Li, Ronnie Ozer
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Publication number: 20110196126Abstract: A process is provided for the synthesis of furan and related compounds by vapor phase decarbonylation of furfural and derivatives. The reaction rate, conversion, and selectivity are enhanced by adding water to the feed. The process can be run at lower temperatures than in similar processes run with essentially dry furan and related compounds.Type: ApplicationFiled: December 8, 2009Publication date: August 11, 2011Applicant: E.I. Du Pont De Nemours and CompanyInventor: Ronnie Ozer
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Patent number: 7989497Abstract: The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.Type: GrantFiled: July 30, 2009Date of Patent: August 2, 2011Assignee: Novartis AGInventors: Urs Baettig, Anne-Marie D'Souza, Peter Hunt, Neil John Press, Simon James Watson
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Patent number: 7985755Abstract: 2,4-Diaminoquinazolines of formula (I) are provided herein and are useful for treating spinal muscular atrophy (SMA).Type: GrantFiled: August 1, 2007Date of Patent: July 26, 2011Assignee: Families of Spinal Muscular AtrophyInventors: Jasbir Singh, Mark E. Gurney
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Publication number: 20110136831Abstract: An N-2-(hetero)arylethylcarboxamide derivative represented by the formula (I) wherein R1 and R2 are each independently a hydrogen atom etc., R3 and R4 are each independently a hydrogen atom etc., each Y is independently a halogen atom; a (C1-C6)alkyl group optionally substituted by halogen atom(s) etc., n is an integer of 1 to 5, A is a specific substituted cyclic group, E is C—H; C—Y (Y is as defined above); or a nitrogen atom, a salt thereof, and a pest controlling agent containing the derivative or salt as an active ingredient show superior performance as compared to the prior art technique, and are is useful particularly as plant disease controlling agents or nematocides having a broad control spectrum at a low dose.Type: ApplicationFiled: March 20, 2007Publication date: June 9, 2011Inventors: Masatsugu Oda, Yoshihiro Matsuzaki, Koji Tanaka, Eiji Takizawa, Motohiro Haseba, Nobutaka Kuroki, Akiyuki Suwa, Kenji Oshima
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Patent number: 7956203Abstract: Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan.Type: GrantFiled: March 27, 2001Date of Patent: June 7, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Vladimir Grushin, Walter Partenheimer, Leo E. Manzer
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Patent number: 7939531Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.Type: GrantFiled: February 20, 2009Date of Patent: May 10, 2011Assignee: Roche Palo AltoInventors: Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K. Kondru, Remy Lemoine, Yan Lou, Timothy D. Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee
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Publication number: 20110105554Abstract: The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selected from (a) ranges K265-V268, V411-L441, N588-Q593, D614-T629, and V630-E646 of SEQ ID NO: 2, said myosin comprising or consisting of (i) the sequence of SEQ ID NO: 2; (ii) the sequence encoded by the sequence of SEQ ID NO: 1; (iii) a sequence being at least 40% identical to the sequence of SEQ ID NO: 2 or to the sequence encoded by the sequence of SEQ ID NO: 1; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of SEQ ID NO: 1; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise K265; or (b) ranges of any one of SEQ ID NOs: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 7Type: ApplicationFiled: November 21, 2008Publication date: May 5, 2011Applicant: KINARIS BIOMEDICALS GMBHInventors: Dietmar Manstein, Roman Fedorov, Georgios Tsiavaliaris, Hans-Joachim Knölker, René Martin, Juliane Kirst, Herwig Gutzeit, Markus Böhl
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Patent number: 7935725Abstract: Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.Type: GrantFiled: October 30, 2008Date of Patent: May 3, 2011Assignee: Janssen Pharmaceutica NVInventors: Scott D. Bembenek, Wendy Eccles, Laurent Gomez, Cheryl A. Grice, Aaron M. Kearney, Adrienne M. Landry-Bayle, Taraneh Mirzadegan, Alejandro Santillán, Jr.
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Publication number: 20110086822Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: October 8, 2010Publication date: April 14, 2011Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Upul Bandarage, Joel Berniac, Beena Bhatia, Jackson Chen, Mohamed Y. Ismail, Oak Kim, Laura Honeyman, Rachid Mechiche, Andre Pearson, Laxma Reddy Nagavelli, Paul Sheahan, Atul K. Verma, Peter Viski, Tadeusz Warchol
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Patent number: 7897606Abstract: Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as COPD.Type: GrantFiled: June 27, 2006Date of Patent: March 1, 2011Assignee: Schering CorporationInventor: Purakkattle J. Biju
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Patent number: 7879858Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or disease states including pain, depression and anxiety.Type: GrantFiled: April 17, 2009Date of Patent: February 1, 2011Assignee: Gruenenthal GmbHInventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
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Publication number: 20100240915Abstract: We disclose a method of extracting an alcohol or furan from a predominantly liquid stream comprising the alcohol or furan, comprising removing cations from the predominantly liquid stream comprising the alcohol or furan, using a cation-exchange resin; removing anions from the predominantly liquid stream comprising the alcohol or furan, using an anion-exchange resin; and recovering alcohol or furan from the predominantly liquid stream comprising the alcohol or furan, using either a vapor permeation membrane, a perevaporation process, or both.Type: ApplicationFiled: January 29, 2010Publication date: September 23, 2010Inventors: Robert Jansen, Anthony Baiada, John Kerr, Peter Lloyd-Jones
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Patent number: 7795287Abstract: A compound having a structure is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.Type: GrantFiled: August 30, 2007Date of Patent: September 14, 2010Assignee: Allergan, Inc.Inventor: David W. Old
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Patent number: 7790728Abstract: The present disclosure relates to a compound of formula (I) wherein: A is an optionally substituted monocyclic or polycyclic aryl or heteroaryl group; B is an optionally substituted monocyclic nitrogen-containing heteroaryl group; and either a) R1 and R2 are chosen from a hydrogen atom and specified substituents, or b) R2, R1 and the —NH— group to which R1 is attached, form a moiety chosen from the moiety of formulae (IIa) and (IIb): or a pharmaceutically acceptable salt thereof, or a N-oxide thereof. The present disclosure also relates to a method for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor.Type: GrantFiled: July 25, 2006Date of Patent: September 7, 2010Assignee: Laboratorios Almirall, S.A.Inventors: Bernat Vidal Juan, Christina Esteve Trias, Lidia Soca Pueyo, Paul Robert Eastwood
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Publication number: 20100212218Abstract: The current invention provides a method for the manufacture of 5-(substituted methyl) 2-methylfuran by reacting 5-(substituted methyl) furfural with hydrogen and a catalyst system, comprising of one or more catalysts. Within the scope of the current invention is the use of 5-(substituted methyl) furfural, and in particular 5-hydroxymethylfurfural and the ethers or esters thereof, which may be obtained from C6 sugars.Type: ApplicationFiled: September 5, 2008Publication date: August 26, 2010Applicant: FURANIX TECHNOLOGIES B.V.Inventor: Gerardus Johannes Maria Gruter
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Publication number: 20100197943Abstract: A biodiesel composition and method are disclosed and claimed whereby a biodiesel fuel is produced without glycerin waste and which has a could point below 32° F.Type: ApplicationFiled: February 3, 2009Publication date: August 5, 2010Inventors: Bryon Tarbet, Kenneth Tarbet
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Patent number: 7759502Abstract: This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.Type: GrantFiled: October 29, 2007Date of Patent: July 20, 2010Assignee: The Trustees of the University of PennsylvaniaInventors: Hank F. Kung, Mei-Ping Kung, Zhi-Ping Zhuang
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Patent number: 7705042Abstract: The invention relates to arylamide and hetereoarylamide compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.Type: GrantFiled: October 20, 2005Date of Patent: April 27, 2010Assignee: Janssen Pharmaceutica NVInventors: Carl R. Illig, Shelley K. Ballentine, Jinsheng Chen, Sanath Meegalla, Jonathan Rudolph, Mark J. Wall, Kenneth J. Wilson, Renee DesJarlais, Carl L. Manthey, Christopher M. Flores, Christopher J. Molloy
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Patent number: 7691884Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for determining ?-amyloid levels in a subject are described.Type: GrantFiled: March 16, 2005Date of Patent: April 6, 2010Assignees: Wyeth, ArQule, Inc.Inventors: Anthony Frank Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier
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Publication number: 20100069630Abstract: The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.Type: ApplicationFiled: November 1, 2007Publication date: March 18, 2010Applicants: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, CRYSTALGENOMICS, INCInventors: Cheol Hae Lee, Hee Jung Jung, Jae Hak Kim, Won Jang Jeong, Joong Myung Cho, Seong Gu Ro, Young Lan Hyun, Cheol Soon Lee
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Patent number: 7662478Abstract: Provided is a polymer comprising a repeating unit represented by formula (1), wherein, A1 represents a divalent group in which the bond distance ratio (bond distance of C(?)-A1/bond distance of C(?)-C(?)) is 1.10 or more; R1, R2, R3, R4, R5, and R6, each independently represent a hydrogen atom, alkyl group, alkyloxy group, aryloxy group, arylalkyloxy group, etc. The polymer is useful as a light-emitting material, a charge transporting material, etc.Type: GrantFiled: October 1, 2004Date of Patent: February 16, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Satoshi Kobayashi, Takanobu Noguchi, Yoshiaki Tsubata, Makoto Kitano, Shuji Doi, Takahiro Ueoka, Akiko Nakazono
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Patent number: 7655680Abstract: Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) —CO—B— wherein B is a C1-6 alkylene group and (ii) —CO—Ba— wherein Ba is a C2-6 alkenylene group, and include optical isomers and salts of the compounds.Type: GrantFiled: May 16, 2005Date of Patent: February 2, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Isao Takemura, Kenji Watanabe, Kunio Oshima, Nobuaki Ito, Junpei Haruta, Hidetaka Hiyama, Masatoshi Chihiro, Hideki Kawasome, Yoko Sakamoto, Hironobu Ishiyama, Takumi Sumida, Kazuhiko Fujita, Hideki Kitagaki
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Publication number: 20100004437Abstract: A method for converting a carbohydrate to a furan in a polar aprotic solvent in the presence of a chloride, bromide, or iodide salt or a mixture thereof and optionally in the presence of an acid catalyst, a metal halide catalyst and/or an ionic liquid (up to 40 wt %). The method can be employed in particular to produce furfural or 5-hydroxymethylfurfural.Type: ApplicationFiled: June 16, 2009Publication date: January 7, 2010Inventors: Joseph Bartholomew BINDER, Ronald Thaddeus Raines
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Patent number: 7625900Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.Type: GrantFiled: October 17, 2007Date of Patent: December 1, 2009Assignee: Gruenenthal GmbHInventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
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Patent number: 7612074Abstract: This invention relates to novel diazabicyclic aryl compounds of the formula wherein: R? represents hydrogen or alkyl; A represents an aromatic monocyclic or bicyclic carbocyclic or heterocyclic; and is hydrogen or a subsituent as defined in the specification. The compounds are cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. The compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.Type: GrantFiled: November 29, 2005Date of Patent: November 3, 2009Assignee: Neurosearch A/SInventors: Dan Peters, Daniel B. Timmermann, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Tino Dyhring Jørgensen
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Patent number: 7579490Abstract: A method of preparing 2,5-bis(hydroxymethyl)tetrahydrofuran comprises heating a reaction mixture comprising 2,5-(hydroxymethyl)furaldehyde, an organic solvent, and a catalyst system comprising nickel and zirconium at a temperature, for a time, and at a pressure sufficient to promote reduction of the 2,5-(hydroxymethyl)furaldehyde to 2,5-bis(hydroxymethyl)tetrahydrofuran to produce a product mixture comprising 2,5-bis(hydroxymethyl)tetrahydrofuran.Type: GrantFiled: November 15, 2005Date of Patent: August 25, 2009Assignee: Archer-Daniels-Midland CompanyInventors: Alexandra J. Sanborn, Paul D. Bloom
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Patent number: 7553867Abstract: The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(?O)—N(R3)— or —N(R3)—C(?O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or aType: GrantFiled: September 4, 2003Date of Patent: June 30, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Kazumasa Hamamura, Shigekazu Sasaki, Yuichiro Amano, Junichi Sakamoto, Kohji Fukatsu
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Publication number: 20090053826Abstract: The invention relates to an electropolymerizable monomer, intended to be polymerized in aqueous solution, comprising a single electropolymerizable unit and an electron-donating group, characterized in that it also comprises at least one arm ionizable in aqueous solution. The invention also relates to the polymerization process, to the electroactive probe thus obtained and to the method for the detection of a target ligand in a biological sample.Type: ApplicationFiled: July 7, 2006Publication date: February 26, 2009Applicants: BIOMERIEUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Aurelie Bouchet, Carole Chaix, Bernard Mandrand
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Patent number: 7442816Abstract: A new composition, SbVPO6+?, in which 0??? 1.5, has been prepared. Crystals of the compound have been grown by several methods, and the crystal structure has been determined. It is related in structure to vanadyl pyrophosphate (VPO), an important selective oxidation catalyst. The compound has shown utility as an oxidation catalyst.Type: GrantFiled: May 12, 2005Date of Patent: October 28, 2008Assignee: E.I. du Pont de Nemours and CompanyInventor: Paul Douglas Vernooy
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Patent number: 7439371Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: GrantFiled: July 11, 2006Date of Patent: October 21, 2008Assignee: Allergan, Inc.Inventors: Julie A. Wurster, Richard C. Yee
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Patent number: 7393963Abstract: A method of preparing 2,5-bis(hydroxymethyl)tetrahydrofuran comprises heating a reaction mixture comprising 2,5-(hydroxymethyl)furaldehyde, an organic solvent, and a catalyst system comprising nickel and zirconium at a temperature, for a time, and at a pressure sufficient to promote reduction of the 2,5-(hydroxymethyl)furaldehyde to 2,5-bis(hydroxymethyl)tetrahydrofuran to produce a product mixture comprising 2,5-bis(hydroxymethyl)tetrahydrofuran.Type: GrantFiled: March 2, 2005Date of Patent: July 1, 2008Assignee: Archer-Daniels-Midland CompanyInventors: Alexandra J. Sanborn, Paul D. Bloom
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Patent number: 7384962Abstract: The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention more particularly relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the Formula (1), their analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxide, pharmaceutically acceptable solvates and the pharmaceutical compositions containing them.Type: GrantFiled: September 28, 2006Date of Patent: June 10, 2008Assignee: Glenmark Pharmaceuticals S.A.Inventors: Balasubramanian Gopalan, Laxmikant Atmaram Gharat, Aftab Dawoodbhai Lakdawala, Usha Karunakaran
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Patent number: 7381827Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.Type: GrantFiled: March 11, 2005Date of Patent: June 3, 2008Assignee: Vertex Pharmaceuticals IncorporatedInventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
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Publication number: 20080033187Abstract: Methods are described for converting carbohydrates including, e.g., monosaccharides, disaccharides, and polysaccharides in ionic liquids to value-added chemicals including furans, useful as chemical intermediates and/or feedstocks. Fructose is converted to 5-hydroxylmethylfurfural (HMF) in the presence of metal halide and acid catalysts. Glucose is effectively converted to HMF in the presence of chromium chloride catalysts. Yields of up to about 70% are achieved with low levels of impurities such as levulinic acid.Type: ApplicationFiled: July 6, 2007Publication date: February 7, 2008Inventors: Haibo Zhao, Johnathan E. Holladay, Zongchao C. Zhang
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Patent number: 7294639Abstract: Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPAR? receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulating and/or restoring skin lipid metabolism, for treating a wide variety of dermatological afflictions, and for preventing and/or treating the signs of aging and/or dry skin.Type: GrantFiled: August 18, 2006Date of Patent: November 13, 2007Assignee: Galderma Research & DevelopmentInventors: Jean-Michel Bernardon, Laurence Clary, Eric Terranova
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Publication number: 20070197806Abstract: A carbonyl compound represented by following Formula (1): wherein R1 represents hydrogen atom or an organic group; and R2 represents hydrogen atom or an organic group having a carbon atom at a bonding site with the carbonyl group in Formula (1), wherein R1 and R2 may be combined to form a ring with adjacent two carbon atoms, or an equivalent thereof is reacted with an unsaturated compound represented by following Formula (2): wherein each of R3, R4, and R5 represents hydrogen atom, a halogen atom, hydroxyl group, or an organic group and wherein R3 and R4 may be combined to form a ring with adjacent two carbon atoms, or a precursor thereof, to yield a furan compound represented by following Formula (3): wherein R3? represents R3, R5 or hydrogen atom; and R1, R2, R3, R4, are R5 are as defined above.Type: ApplicationFiled: February 22, 2007Publication date: August 23, 2007Inventors: Yasutaka Ishii, Tatsuya Nakano, Takahiro Iwahama
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Patent number: 7256219Abstract: The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R6-R10 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.Type: GrantFiled: March 14, 2002Date of Patent: August 14, 2007Assignee: Cytovia, Inc.Inventors: Sui Xiong Cai, P. Sanjeeva Reddy, John A. Drewe, Bao Ngoc Nguyen, Shailaja Kasibhatla
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Patent number: 7128983Abstract: A furan-containing compound of formula (I): Ar is aryl, heteroaryl, or oligoaryl; A is furyl; B is aryl or heteroaryl; R1 is hydrogen, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, or oligoaryl; and R2 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl. The compound is useful as a hole transporting material in an organic light emitting diode device.Type: GrantFiled: August 18, 2003Date of Patent: October 31, 2006Assignee: Academia SinicaInventors: Tien-yau Luh, Lingzhi Zhang, Chin-Fa Lee, Chung-Chih Wu, Cheih-Wei Chen
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Patent number: 7122564Abstract: Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPAR? receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulating and/or restoring skin lipid metabolism, for treating a wide variety of dermatological afflictions, and for preventing and/or treating the signs of aging and/or dry skin.Type: GrantFiled: January 26, 2005Date of Patent: October 17, 2006Assignee: Galderma Research & DevelopmentInventors: Jean-Michel Bernardon, Laurence Clary, Eric Terranova
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Patent number: 7098201Abstract: A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wherein RB and RC each is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1 is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1 is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.Type: GrantFiled: June 18, 2003Date of Patent: August 29, 2006Assignee: Shionogi & Co., Ltd.Inventors: Toshio Fujishita, Tomokazu Yoshinaga, Akihiko Sato
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Patent number: 7041668Abstract: The present invention discloses and claims benzimidazole compounds of formula (I): in which A is aryl or heteroaryl; R1 is selected from optionally substituted alkyl, alkoxy, aryl or heteroaryl, NH-lower alkyl or NH-cycloalkyl, or halogen, NH2; 1-imidazolyl or SO2Me; R2 is selected from optionally substituted —CO-alkyl, —CO-cycloalkyl, —CO-aralkyl, —CO-aryl, —CO-alkoxy, aryl or aralkyl, or —CO-amino, CO—NHR3 or CO—R3R4 wherein R3 and R4 are selecteded independently from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, fluoroalkyl, alkynyl, heteroalkyl, alkylheteroalkyl, aryl, aralkyl or together form an alkylene chain optionally containing one to 4 heteroatoms; a pharmaceutically acceptable salt or a prodrug thereof; the use of compounds of formula (I) for the treatment of cancer, and pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents.Type: GrantFiled: March 25, 2004Date of Patent: May 9, 2006Assignee: Aventis Pharma S.A.Inventors: Francois Clerc, Francois Hamy, Isabelle Depaty, Odile Angouillant-Boniface, Stéphanie Deprets, Chantal Carrez, Manfred Roesner
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Patent number: 7019155Abstract: Disclosed is a method for the hydrogenation of tetrahydroxybutane in the presence of supported rhenium catalysts and an acid to form tetrahydrofuran and its precursors.Type: GrantFiled: November 12, 2002Date of Patent: March 28, 2006Assignee: Invista North America S.A.R.L.Inventor: Leo Ernest Manzer
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Patent number: 7015246Abstract: The invention relates to novel benzofuran derivatives, to processes for preparing them and to their uses in medicaments.Type: GrantFiled: October 10, 2002Date of Patent: March 21, 2006Assignee: Bayer AktiengesellschaftInventors: Carsten Schmeck, Ulrich Müller, Gunter Schmidt, Josef Pernerstorfer, Hilmar Bischoff, Axel Kretschmer, Verena Vöhringer, Christiane Faeste, Helmut Haning, Markus Hauswald, Delf Schmidt, Martin Zoche, Heiner Apeler, Willi Jonghaus, Peter Reinemer