Halogen Attached Directly To The Hetero Ring By Nonionic Bonding Patents (Class 549/81)
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Publication number: 20150011749Abstract: Metal-accumulating plants for preparing compositions including a metal catalyst derived from the plants. The composition is substantially devoid of organic matter. Also, carrying out chemical reactions with the compositions prepared from metal-accumulating plants.Type: ApplicationFiled: March 5, 2013Publication date: January 8, 2015Applicants: UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Claude Grison, Vincent Escande
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Patent number: 8871952Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in Claim 1, and to liquid-crystalline media comprising at least one compound of the formula I, and to electro-optical displays containing a liquid-crystalline medium of this type.Type: GrantFiled: November 20, 2013Date of Patent: October 28, 2014Assignee: Merck Patent GmbHInventors: Lars Lietzau, Louise Diane Farrand, Markus Czanta, Harald Hirschmann, Michael Wittek, Izumi Saito, Brigitte Schuler
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Publication number: 20140275539Abstract: Provided herein are stabilized radioiodinated and astatinated compounds, and to methods for their preparation.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Ground Fluor Pharmaceuticals, Inc.Inventor: Stephen G. DiMagno
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Publication number: 20140107348Abstract: The present invention relates to methods of initiating a reaction represented by scheme 1 wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydrogen or an organic radical; wherein the catalyst comprises copper and a ligand; comprising providing the compound of formula III in liquid form prior to contacting the compound of formula III with the catalyst.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: SYNGENTA LIMITEDInventors: George Robert HODGES, Lisa MITCHELL, Alan James ROBINSON
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Patent number: 8637678Abstract: The present invention relates to methods of initiating a reaction represented by scheme (1), wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydrogen or an organic radical; wherein the catalyst comprises copper and a ligand; comprising providing the compound of formula III in liquid form prior to contacting the compound of formula III with the catalyst.Type: GrantFiled: December 16, 2009Date of Patent: January 28, 2014Assignee: Syngenta LimitedInventors: George Robert Hodges, Lisa Mitchell, Alan James Robinson
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Publication number: 20130144071Abstract: A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.Type: ApplicationFiled: January 30, 2013Publication date: June 6, 2013Applicants: NIPPOH CHEMICALS CO., LTD., JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Japan Science and Technology Agency, Nippoh Chemicals Co., Ltd.
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Patent number: 8436013Abstract: The invention features compositions and methods that are useful for treating or preventing AAT deficiency and associated conditions. In addition, the invention provides methods for identifying compounds useful for treatment of AAT deficiency and associated conditions.Type: GrantFiled: July 9, 2009Date of Patent: May 7, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Chen Liu, David A. Ostrov
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Publication number: 20120171111Abstract: The present invention provides a process for producing an oxidation reaction product of an aromatic compound, having excellent environmental load reduction performance, cost reduction performance, etc. Provided is a process for producing an oxidation reaction product of a raw material aromatic compound by reacting the raw material aromatic compound with an oxidizing agent. The process further uses an electron donor-acceptor linked molecule. The process includes the step of: reacting the electron donor-acceptor linked molecule in an electron-transfer state, the oxidizing agent, and the raw material aromatic compound, thereby generating an oxidation reaction product resulting from oxidation of the raw material aromatic compound.Type: ApplicationFiled: September 15, 2010Publication date: July 5, 2012Applicant: OSAKA UNIVERSITYInventors: Kei Ohkubo, Shunichi Fukuzumi, Kentaro Mizushima
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Patent number: 8115018Abstract: What is described is a process for brominating alkylthiophene, in which an alkylthiophene of the general formula (I) where R is a branched or unbranched alkyl radical having 1 to 12 carbon atoms is contacted with stoichiometric amounts of HBr and H2O2, optionally in the presence of a solvent.Type: GrantFiled: April 7, 2009Date of Patent: February 14, 2012Assignee: SALTIGO GmbHInventors: Antje Hieronymi, Andreas Martin, Witold Broda
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Patent number: 8063067Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.Type: GrantFiled: July 23, 2009Date of Patent: November 22, 2011Assignee: Merck Patent GmbHInventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
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Publication number: 20110263869Abstract: The present invention relates to methods of initiating a reaction represented by scheme (1), wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydrogen or an organic radical; wherein the catalyst comprises copper and a ligand; comprising providing the compound of formula III in liquid form prior to contacting the compound of formula III with the catalyst.Type: ApplicationFiled: December 16, 2009Publication date: October 27, 2011Applicant: SYNGENTA CROP PROTECTION, LLCInventors: George Robert Hodges, Lisa Mitchell, Alan James Robinson
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Patent number: 7759502Abstract: This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.Type: GrantFiled: October 29, 2007Date of Patent: July 20, 2010Assignee: The Trustees of the University of PennsylvaniaInventors: Hank F. Kung, Mei-Ping Kung, Zhi-Ping Zhuang
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Patent number: 7659411Abstract: The present invention provides a process for producing a 2-acylthiophene compound which has a low content of the 3-isomer generated as a by-product, the process comprising reacting a thiophene compound represented by formula (1): wherein R1is a hydrogen atom, a C1-6 alkyl group, a phenyl group, or a halogen atom, with at least one member selected from the group consisting of acid anhydrides represented by formula (2): wherein R2 is a C1-6 alkyl group or a phenyl group, and acid halides represented by formula (3): wherein R2 is as defined above and X is a halogen atom, in the presence of a solid acid catalyst at a temperature less than 75° C. in the absence of solvent, thus producing a 2-acylthiophene compound represented by formula (4): wherein R1 and R2 are as defined above.Type: GrantFiled: December 13, 2004Date of Patent: February 9, 2010Assignee: Sumitomo Seika Chemicals Co., Ltd.Inventors: Seiji Bando, Syuzo Satake, Hirokazu Kagano
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Patent number: 7632846Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.Type: GrantFiled: April 6, 2005Date of Patent: December 15, 2009Assignee: Merck Patent Gesellschaft mit beschrankterInventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gèrard Ferrand, Yves Bonhomme
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Patent number: 7608726Abstract: The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(?O), C(?O)OH, C1-4alkyloxyC(?O), C1-4alkylC(?O), mono- or di(C1-4alkyl)aminoC(?O), arylaminoC(?O), N-(aryl)-N—(C1-4alkyl)aminoC(?O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(?O), aminoC(?O), C1-4alkyloxyC(?O), mono- or di(C1-4alkyl)aminoC(?O), C1-4alkylC(?O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).Type: GrantFiled: November 14, 2003Date of Patent: October 27, 2009Assignee: Tibotec Pharmaceuticals Ltd.Inventors: Bart Rudolf Romanie Kesteleyn, Wim Van De Vreken, Natalie Maria Francisca Kindermans, Maxime Francis Jean-Marie Ghislain Canard, Kurt Hertogs, Eva Bettens, Veronique Corine Paul De Vroey, Dirk Edward Désiré Jochmans
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Publication number: 20090259053Abstract: What is described is a process for brominating alkylthiophene, in which an alkylthiophene of the general formula (I) where R is a branched or unbranched alkyl radical having 1 to 12 carbon atoms is contacted with stoichiometric amounts of HBr and H2O2, optionally in the presence of a solvent.Type: ApplicationFiled: April 7, 2009Publication date: October 15, 2009Applicant: SALTIGO GMBHInventors: Antje Hieronymi, Andreas Martin, Witold Broda
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Publication number: 20090159876Abstract: Disclosed is an adequately stable organic semiconductor material which can be used in a coating process while having high regularity and crystallinity. For obtaining such an organic semiconductor material, there is used a compound wherein 6-20 five-membered and/or six-membered aromatic rings are bound. This compound contains a partial structure represented by the formula (1) below, while having a mobility of not less than 1.0×10?3 cm2/Vs and an ionization potential in the solid state of not less than 4.8 eV and not more than 5.6 eV. (1) In the formula, R1 and R2 independently represent a hydrogen atom or a monovalent organic group. In this connection, at least one of R1 and R2 is an optionally substituted aromatic group.Type: ApplicationFiled: September 20, 2006Publication date: June 25, 2009Applicant: MITSUBISHI CHEMICAL CORPORATIONInventors: Yoshihiro Ohba, Kazuaki Sato, Yoshimasa Sakai, Shinji Aramaki
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Patent number: 7223780Abstract: The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as for inhibiting the formation of thrombin or for therapeutically treating a patient suffering from, or subject to, a disease state associated with a cardiovascular disorder.Type: GrantFiled: May 19, 2004Date of Patent: May 29, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: Marc Nazare, Volker Laux, Armin Bauer, Michael Wagner
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Patent number: 7208610Abstract: An improved process and catalyst system for the isomerization of halothiophenes. More particularly, an improved process for the isomerization of 2-halothiopehenes to 3-halothiophenes by reacting a 2-halothiophene with a catalyst and in the presence of a base. The addition of a base additive to the acidic zeolite catalyst allows the desired isomerization reaction to take place while suppressing side-reactions that result in the decomposition of thiophene rings. The catalyst lifetime is thus increased and the amount of catalyst needed for the reaction is reduced, lowering cost.Type: GrantFiled: January 12, 2005Date of Patent: April 24, 2007Assignee: Honeywell International Inc.Inventors: Christian Werner, Andreas Kanschik-Conradsen, Bernd Kellermeier, Hans-Jürgen Schmidt
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Patent number: 7205414Abstract: A method for the formation of 3-alkylthiophenes or 3-arylthiophenes from 3-halothiophenes. More particularly, improvements on the Kumada coupling reaction for the production of 3-alkylthiophenes or 3-arylthiophenes by reacting a 3-halothiophene with an alkylmagnesiumhalide or arylmagnesiumhalide Grignard reagent in the presence of a catalyst and a 2-methyl tetrahydrofuran solvent. The 2-methyl tetrahydrofuran solvent allows for higher concentrations of the Grignard reagent with minimal or no dithienyl side product generation, achieving higher product yields and at a lower cost than other known methods.Type: GrantFiled: January 12, 2005Date of Patent: April 17, 2007Assignee: Honeywell International Inc.Inventors: Christian Werner, Frauke Platz, Andreas Kanschik-Conradsen
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Patent number: 6676857Abstract: Mono-, oligo- and polymers comprising one or more identical or different recurring units of formula I —[(Y)a—(D)b—(Z)c]— I wherein D is a 3-substituted-4-fluorothiophene group of formula II, wherein Y, Z, R1, a, b and c have the meanings defined herein, are useful as semiconductors or charge transport materials.Type: GrantFiled: July 25, 2002Date of Patent: January 13, 2004Assignee: Merck Patent Gesellschaft mitInventors: Martin Heeney, Louise Farrand, Mark Giles, Marcus Thompson, Steven Tierney, Maxim Shkunov, David Sparrowe, Iain McCulloch
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Publication number: 20030149272Abstract: The invention concerns a method for preparing a polyaromatic compound comprising at least a chain formation of two aromatic cycles. The method for preparing a polycyclic aromatic compound comprising at least a chain formation of two aromatic cycles is characterised in that it consists in reacting an aromatic compound bearing a leaving group and an alkaline organometallic compound, in the presence of an efficient amount of a nickel catalyst, said element being optionally complexed with at least a co-ordination agent or ligand.Type: ApplicationFiled: November 4, 2002Publication date: August 7, 2003Inventors: Henri-Jean Cristau, Corinne Bouchitte, Marc Taillefer, Jean-Francis Spindler, Thierry Schlama
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Patent number: 6262101Abstract: Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor &agr;, nuclear factor &kgr;B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovis replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.Type: GrantFiled: August 16, 2000Date of Patent: July 17, 2001Assignee: Celgene CorporationInventors: George W. Muller, Mary Shire
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Patent number: 6200353Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula at least one coupler comprising a compound of the formula: wherein R is selected from the group consisting of C1 to C2 alkyl and hydroxyethyl, R1 is selected from the group consisting of hydrogen, chlorine, bromine, C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C3 hydroxyalkyl and C1 to C3 hydroxyalkoxy, and X is O, S or NH.Type: GrantFiled: February 1, 2000Date of Patent: March 13, 2001Assignee: Bristol Myers Squibb CompanyInventors: Mu-Ill Lim, Linas R. Stasaitis, Yuh-Guo Pan
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Patent number: 6127550Abstract: This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.Type: GrantFiled: March 11, 1999Date of Patent: October 3, 2000Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: Luc Grondard, Jean-Paul Casimir, Patrick Leon, Michael K. O'Brien, Matthew R. Powers, Daniel Robin
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Patent number: 5994563Abstract: Benzyl-phosphonate compounds represented by the formula I: ##STR1## are disclosed as useful in treating bone wasting diseases and as an immunosuppresant.Type: GrantFiled: January 19, 1999Date of Patent: November 30, 1999Assignee: Ortho Pharmaceutical CorporationInventors: Scott Beers, Roger F. Frechette, Elizabeth A. Malloy, Charles Schwender, Wei Wu
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Patent number: 5883106Abstract: Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar.sup.1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, indolyl, indazolyl and benzimidazolyl, which is bonded to X.sup.1 through a ring nitrogen atom, and which may be optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino, and C.sub.1-4 alkyl; X.sup.1 is a direct bond or C.sub.1-4 alkylene; Ar.sup.2 is phenylene optionally substituted with halo, hydroxy, cyano, and amino X.sup.2 is --A--X-- or --X--A-- wherein A is a direct bond or C.sub.1-4 alkylene and X is oxy, thio, sulfinyl or sulfonyl; Ar.sup.3 is phenylene, pyridylene, thienylene, furylene, oxazolylene or thiazolylene optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino and C.sub.1-4 alkyl; R.sup.1 and R.sup.2 are each C.sub.Type: GrantFiled: February 6, 1998Date of Patent: March 16, 1999Assignee: Pfizer Inc.Inventors: Rodney W. Stevens, Takashi Mano, Kazunari Nakao, Yoshiyuki Okumura
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Patent number: 5780640Abstract: Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use.L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.Type: GrantFiled: June 5, 1995Date of Patent: July 14, 1998Assignee: Hoechst AktiengesellschaftInventors: Gerhard Kretzschmar, Johannes Meiwes, Manfred Schudok, Peter Hammann, Ulrich Lerch, Susanne Grabley
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Patent number: 5534639Abstract: There are disclosed novel hydroquinone derivatives of the formulas: ##STR1## The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments, and the derivatives of the formula (II) are intermediates for the production thereof.Type: GrantFiled: April 24, 1995Date of Patent: July 9, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirotomo Masuya, Masayoshi Yamaoka
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Patent number: 5424448Abstract: A process for synthesizing carbonic anhydrase inhibitors is disclosed.Type: GrantFiled: January 14, 1994Date of Patent: June 13, 1995Assignee: Alcon Laboratories, Inc.Inventors: William D. Dean, Paul W. Zinke, Steven J. Sproull, Michael E. Deason, Raymond E. Conrow, Anura P. Dantanarayana
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Patent number: 5416235Abstract: A process for the preparation of aromatic compounds of the general formula I,Ar--X Iin which Ar represents an optionally substituted aryl group and X represents a group OH, Cl, Br or CN, by reaction of an aryl diazoniumsalt of the formula II,Ar--N.dbd.N.sup.+ Y.sup.- IIin which Ar is as defined above and Y represents a suitable counterion, with water, hydrogen chloride or a salt thereof, hydrogen bromide or a salt thereof, or a cyanide in the presence of a copper(I)salt, characterized in that the copper(I)salt is a copper(I)salt derived from an hydroxy carboxylic acid.Type: GrantFiled: November 1, 1993Date of Patent: May 16, 1995Assignee: Octel Chemicals LimitedInventors: Bruce C. Gilbert, Peter Hanson, Jason R. Jones, Allan W. Timms
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Patent number: 5405937Abstract: The invention relates to thiophenes substituted by an alkoxy group containing at least one fluorine atom.The invention also relates to the polymers derived from these substituted thiophenes and to the electrically conductive polymers containing these polymers.The invention also relates to processes for obtaining these thiophenes, these polymers and these electrically conductive polymers.The invention also relates to the uses of these thiophenes, of these polymers and of these electrically conductive polymers as well as to the devices containing the polymers and the electrically conductive polymers.Type: GrantFiled: July 28, 1992Date of Patent: April 11, 1995Assignee: Solvay (Societe Anonyme)Inventors: Marc Lemaire, Werner Burchner, Ahmed El Kassmi, Etienne Hannecart
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Patent number: 5319103Abstract: Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(1S-oxo-3R-thiolanylthio)-2-penem-3-carboxylic acid and 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid, and pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, useful as systemic antibacterial agents; and intermediates and processes which are useful in the said synthesis of said diastereoisomers.Type: GrantFiled: February 11, 1993Date of Patent: June 7, 1994Assignee: Pfizer Inc.Inventor: Robert A. Volkmann
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Patent number: 5294522Abstract: A novel photochromic compound as a photoreactive material making use of photochromism is provided, which compound is expressed by the following formula (1) or (2)): ##STR1## wherein R is alkyl, alkoxy, perfluoroalkyl or cyano; X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and X.sub.6 are each H, halogen, alkyl, alkoxy, cyano, alkanoyloxy or alkyloxycarbonyl, or a substituted or unsubstituted benzene ring is formed by condensation between at adjacent groups among X.sub.1 to X.sub.6 ; Y is Y.sub.1 C=CY.sub.2, O, S, SO, SO.sub.2 or NY.sub.3 wherein Y.sub.1 and Y.sub.2 are each as defined in the case of the above X.sub.1 to X.sub.6 and Y.sub.3 is H, alkyl, alkanoyl, alkyloxycarbonyl or aryl; and the symbol refers to occurrence of E- or Z-isomer, and which compound is useful as rewritable optical memory element or photo-display element and also as solar energy-storage material, duplicating material, masking material, optical filter, toys, etc.Type: GrantFiled: March 2, 1993Date of Patent: March 15, 1994Assignee: Chisso CorporationInventors: Manabu Uchida, Masahiro Irie
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Patent number: 5182348Abstract: Compounds of the formula (1) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 have the meanings given in the description, and the other radicals have the following meanings:X, Y and Z denote identical or different divalent radicals --O--, --S--, --N(R.sup.9)-- or --C(R.sup.10).dbd.C(R.sup.11)--, with the proviso that at least one of the radicals, X, Y and Z is not a radical of the formula --C(R.sup.10).dbd.C(R.sup.11)--, and whereinR.sup.9 is a hydrogen atom, a branched or unbranched C.sub.1 - to C.sub.8 -alkyl radical or an optionally substituted phenyl radical, andR.sup.10 and R.sup.11 are, in each case, identical or different radicals which have one of the meanings of R.sup.1,R.sup.7 and R.sup.8 denote identical or different radicals, that is to say hydrogen atoms or C.sub.1 - to C.sub.6 -alkyl or phenyl radicals, andn, m and o denote identical or different integers with a value of from 1 to 10.Type: GrantFiled: August 19, 1991Date of Patent: January 26, 1993Assignee: Wacker-Chemie GmbHInventors: Hermann Braeunling, Richard Becker, Georg Bloechl
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Patent number: 4981868Abstract: This invention relates to novel 3-heteroaryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.Type: GrantFiled: July 25, 1989Date of Patent: January 1, 1991Assignee: Merrell Dow PharmaceuticalInventors: James R. McCarthy, Donald P. Matthews, Charlotte L. Barney
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Patent number: 4895992Abstract: A process for iodinating aromatic compounds by reacting an aromatic compound with oxygen at low temperatures in the presence of a non-acid catalyst containing an oxidation catalyst. The catalyst may be regenerated by heating the catalyst in the presence of oxygen.Type: GrantFiled: September 19, 1988Date of Patent: January 23, 1990Assignee: Eastman Kodak CompanyInventors: Mark Rule, Gerald C. Tustin, Donald L. Carver, Jerry S. Fauver
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Patent number: 4889865Abstract: Mono, di and tri-esters of 1,8-dihydroxy-10-phenyl-9-anthrone or -9-anthranol have the formula ##STR1## wherein p is 0 or 1,(a) when p=0, t=1 and R.sub.2 represents hydrogen or --COR.sub.3,(b) when p=1, t=0 and R.sub.1 and R.sub.2 each independently represent hydrogen or --COR.sub.3,R.sub.3 represents linear or branched alkyl having 1-17 carbon atoms, cycloalkyl, phenyl or phenyl substituted by lower alkyl, lower alkoxy, halogen, a nitro function, --CF.sub.3 or a hydroxyl function, and mixtures of said esters. These esters are prepared by reacting 1,8-dihydroxy-10-phenyl-9-anthrone with an activated form of an acid. The esters are useful in human or veterinary medicine and in cosmetic compositions.Type: GrantFiled: February 21, 1989Date of Patent: December 26, 1989Assignee: Centre International de Recherches Dermatologiques C.I.R.D.Inventors: Braham Shroot, Gerard Lang, Jean Maignan, Serge Restle, Christopher Hensby, Michel Colin
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Patent number: 4889940Abstract: A process for the preparation of a thiophene derivative which is substituted at the beta-position by a bromine atom, which comprises reacting the corresponding beta-unsubstituted thiophene with an aromatic compound which is substituted with a bromine atom, in the presence of an alkali metal amide and a catalyst which is capable of forming a complex with the cation of the alkali metal amide.Type: GrantFiled: June 13, 1988Date of Patent: December 26, 1989Assignee: Shell Internationale Research Maatschappij B.V.Inventors: Peter R. Grosvenor, Lance S. Fuller
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Patent number: 4739057Abstract: A process for converting organic hydroxyl-containing compounds to halides which comprises reacting the hydroxyl-containing compound with a phosphorushalide reagent of formula: R.sub.n PX.sub.5-n wherein n is selected from 1, 2 and 3; R is selected from the group consisting of C-6 to C-10 aryl and substituted aryl wherein the substituents are selected from the group consisting of straight and branched chain alkyl, alkoxy, and haloalkyl, halogen, sulfonate and mixtures thereof; and X is a halogen. It is preferred to carry out the reaction in the presence of an arylphosphorusoxydihalide solvent. The use of an arylphosphorustetrahalide and particularly phenylphosphorustetrachloride is preferred. The arylphoshorustetrahalide can be prepared in situ by contacting a solution of the corresponding arylphosphorusdihalide in an arylphosphorusoxydihalide solvent with a halogen. The process can further comprise the step of heating the reaction mixture. Maintaining a reaction temperature of from about 0.degree. C.Type: GrantFiled: June 30, 1986Date of Patent: April 19, 1988Assignee: Stauffer Chemical Co.Inventors: Andrea Leone-Bay, Elliott Bay, Peter E. Timony
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Patent number: 4604470Abstract: The invention relates to a process for the isomerization of halogenated thiophenes on zeolite catalysts. In this manner, in particular, 2-chlorothiophene is isomerized to 3-chlorothiophene and 2-bromothiophene is isomerized to 3-bromothiophene. Particularly suitable zeolites are synthetic zeolites of the pentasil, mordenite or faujasite type in their acid form.Type: GrantFiled: May 23, 1985Date of Patent: August 5, 1986Assignee: Hoechst AktiengesellschaftInventors: Klaus Eichler, Ernst I. Leupold
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Patent number: 4513137Abstract: Mono- or bis(iodonium salts) are produced in neutral organic solvents by the reaction of an [hydroxy (organosulfonyloxy)iodo]arene with a bis(triorganosilyl)arene, a bis(trihalosilyl)arene, or with a mono- or bis(triorganosilyl)heterocyclic compound, or a mono- or bis(trihalosilyl)heterocyclic. The iodonium salts are made under conditions of regiospecific control.Type: GrantFiled: April 9, 1981Date of Patent: April 23, 1985Assignee: The University of AkronInventors: Gerald F. Koser, Carol S. Carman
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Patent number: 4282227Abstract: 3,4-Dihydroxyphenyltetrahydrothieno[2,3-c] or [3,2-c] pyridines are prepared by cyclization of a N-thienylmethyl-2-(3',4'-dimethoxyphenyl)-ethanolamine. These compounds have renal vasodilating activity. A species is 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydrothieno[2,3-c]pyridine and its pharmaceutically acceptable acid addition salts or esters.Type: GrantFiled: May 22, 1980Date of Patent: August 4, 1981Assignee: SmithKline CorporationInventor: L. Martin Brenner
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Patent number: 4192884Abstract: Halo-substituted 4-(((thienyl)methyl)amino)benzoic acids, the corresponding esters and salts thereof, and a method for lowering serum lipid levels in mammals.Type: GrantFiled: June 12, 1978Date of Patent: March 11, 1980Assignee: The Dow Chemical CompanyInventors: Eugene R. Wagner, Donald P. Matthews
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Patent number: 4169839Abstract: A method for preparing a 3-iodothiophene from a corresponding 3-bromothiophene comprising reacting with copper(I)iodide in a polar aprotic solvent and at an elevated temperature a 3-bromothiophene of formula ##STR1## wherein R.sub.1 is H or a C.sub.1-4 alkyl group,R.sub.2 is H or a C.sub.1-2 alkyl group andR.sub.3 is H or a C.sub.1-2 alkyl group,With the proviso that not more than one of R.sub.2 and R.sub.3 is an alkyl group.Type: GrantFiled: November 27, 1978Date of Patent: October 2, 1979Assignee: Oce-Andeno B.V.Inventors: Joannes P. M. Houbiers, Francina H. J. Thijssen