Three Or More Halogens Attached Directly To The Hetero Ring By Nonionic Bonding Patents (Class 549/82)
  • Publication number: 20140275539
    Abstract: Provided herein are stabilized radioiodinated and astatinated compounds, and to methods for their preparation.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Ground Fluor Pharmaceuticals, Inc.
    Inventor: Stephen G. DiMagno
  • Patent number: 8440711
    Abstract: The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the treatment of damages caused by ischemia and reperfusion.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: May 14, 2013
    Assignee: Dompe Pha.r.ma S.p.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Maria Candida Cesta
  • Patent number: 5294522
    Abstract: A novel photochromic compound as a photoreactive material making use of photochromism is provided, which compound is expressed by the following formula (1) or (2)): ##STR1## wherein R is alkyl, alkoxy, perfluoroalkyl or cyano; X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and X.sub.6 are each H, halogen, alkyl, alkoxy, cyano, alkanoyloxy or alkyloxycarbonyl, or a substituted or unsubstituted benzene ring is formed by condensation between at adjacent groups among X.sub.1 to X.sub.6 ; Y is Y.sub.1 C=CY.sub.2, O, S, SO, SO.sub.2 or NY.sub.3 wherein Y.sub.1 and Y.sub.2 are each as defined in the case of the above X.sub.1 to X.sub.6 and Y.sub.3 is H, alkyl, alkanoyl, alkyloxycarbonyl or aryl; and the symbol refers to occurrence of E- or Z-isomer, and which compound is useful as rewritable optical memory element or photo-display element and also as solar energy-storage material, duplicating material, masking material, optical filter, toys, etc.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: March 15, 1994
    Assignee: Chisso Corporation
    Inventors: Manabu Uchida, Masahiro Irie
  • Patent number: 5068465
    Abstract: This invention relates to novel 3-aryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: November 26, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: James R. McCarthy, Charlotte L. Barney, Donald P. Matthews
  • Patent number: 4981868
    Abstract: This invention relates to novel 3-heteroaryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.
    Type: Grant
    Filed: July 25, 1989
    Date of Patent: January 1, 1991
    Assignee: Merrell Dow Pharmaceutical
    Inventors: James R. McCarthy, Donald P. Matthews, Charlotte L. Barney
  • Patent number: 4816071
    Abstract: A coating composition comprising a film forming binder and an antifoulingly effective amount of at least one of 3,3,4, 4-tetrachlorotetrahydrothiophene-1,1,-dioxide and 3,3, 4-trichlorotetrahydrothiophene-1,1-dioxide as an effective ingredient is highly useful as an underwater antifouling agent.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: March 28, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Takashi Watanabe, Ikuo Sumina
  • Patent number: 4604470
    Abstract: The invention relates to a process for the isomerization of halogenated thiophenes on zeolite catalysts. In this manner, in particular, 2-chlorothiophene is isomerized to 3-chlorothiophene and 2-bromothiophene is isomerized to 3-bromothiophene. Particularly suitable zeolites are synthetic zeolites of the pentasil, mordenite or faujasite type in their acid form.
    Type: Grant
    Filed: May 23, 1985
    Date of Patent: August 5, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Eichler, Ernst I. Leupold
  • Patent number: 4192884
    Abstract: Halo-substituted 4-(((thienyl)methyl)amino)benzoic acids, the corresponding esters and salts thereof, and a method for lowering serum lipid levels in mammals.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: March 11, 1980
    Assignee: The Dow Chemical Company
    Inventors: Eugene R. Wagner, Donald P. Matthews