Abstract: The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the treatment of damages caused by ischemia and reperfusion.
Type:
Grant
Filed:
December 18, 2007
Date of Patent:
May 14, 2013
Assignee:
Dompe Pha.r.ma S.p.A.
Inventors:
Marcello Allegretti, Andrea Aramini, Maria Candida Cesta
Abstract: A novel photochromic compound as a photoreactive material making use of photochromism is provided, which compound is expressed by the following formula (1) or (2)): ##STR1## wherein R is alkyl, alkoxy, perfluoroalkyl or cyano; X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and X.sub.6 are each H, halogen, alkyl, alkoxy, cyano, alkanoyloxy or alkyloxycarbonyl, or a substituted or unsubstituted benzene ring is formed by condensation between at adjacent groups among X.sub.1 to X.sub.6 ; Y is Y.sub.1 C=CY.sub.2, O, S, SO, SO.sub.2 or NY.sub.3 wherein Y.sub.1 and Y.sub.2 are each as defined in the case of the above X.sub.1 to X.sub.6 and Y.sub.3 is H, alkyl, alkanoyl, alkyloxycarbonyl or aryl; and the symbol refers to occurrence of E- or Z-isomer, and which compound is useful as rewritable optical memory element or photo-display element and also as solar energy-storage material, duplicating material, masking material, optical filter, toys, etc.
Abstract: This invention relates to novel 3-aryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.
Type:
Grant
Filed:
June 15, 1990
Date of Patent:
November 26, 1991
Assignee:
Merrell Dow Pharmaceuticals Inc.
Inventors:
James R. McCarthy, Charlotte L. Barney, Donald P. Matthews
Abstract: This invention relates to novel 3-heteroaryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.
Type:
Grant
Filed:
July 25, 1989
Date of Patent:
January 1, 1991
Assignee:
Merrell Dow Pharmaceutical
Inventors:
James R. McCarthy, Donald P. Matthews, Charlotte L. Barney
Abstract: A coating composition comprising a film forming binder and an antifoulingly effective amount of at least one of 3,3,4, 4-tetrachlorotetrahydrothiophene-1,1,-dioxide and 3,3, 4-trichlorotetrahydrothiophene-1,1-dioxide as an effective ingredient is highly useful as an underwater antifouling agent.
Abstract: The invention relates to a process for the isomerization of halogenated thiophenes on zeolite catalysts. In this manner, in particular, 2-chlorothiophene is isomerized to 3-chlorothiophene and 2-bromothiophene is isomerized to 3-bromothiophene. Particularly suitable zeolites are synthetic zeolites of the pentasil, mordenite or faujasite type in their acid form.
Abstract: Halo-substituted 4-(((thienyl)methyl)amino)benzoic acids, the corresponding esters and salts thereof, and a method for lowering serum lipid levels in mammals.