Ring In The Alcohol Moiety Patents (Class 554/228)
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Publication number: 20150071908Abstract: Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.Type: ApplicationFiled: September 12, 2013Publication date: March 12, 2015Applicant: Biosuccess Biotech Co. Ltd.Inventors: Zheng Tao Han, Hung-Fong Chen
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Publication number: 20140371311Abstract: The present invention relates to an injenane-type diterpene compound derived from Euphorbia kansui Liou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.Type: ApplicationFiled: September 28, 2012Publication date: December 18, 2014Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Sei Ryang Oh, Jae Wha Kim, Hyeong Kyu Lee, Piseth Khiev, Doo Young Kim, Jung Hee Kim, Jae Sung Song, Kyung Seop Ahn
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Patent number: 8895040Abstract: The present invention relates to cosmetic and/or personal care formulations and/or compounds. In one embodiment, the present invention relates to ester compounds that can be used in various personal care formulations and/or compounds. In another embodiment, the present invention relates to branced ester compounds having a molecular weight of at least about 1,500 daltons that can be used in various personal care formulations and/or compounds.Type: GrantFiled: June 4, 2009Date of Patent: November 25, 2014Assignee: Lubrizol Advanced Materials, Inc.Inventors: Brian J. Vondruska, Peter Frank, Anchuu Wu
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Patent number: 8742148Abstract: Dimers of jojoba oil wax esters are prepared by reacting the wax esters in the presence of a catalytically effective amount of an acid catalyst in supercritical CO2. In the reaction, the double bonds of the wax esters are opened and cross link or polymerize two wax esters as dimers. The jojoba ester dimers which are produced are of the formula: wherein R1 and R1? are independently selected from the group consisting of C15-C23 monounsaturated hydrocarbons, R2 and R2? are independently selected from the group consisting of C8-C14 saturated hydrocarbons, and R3 and R3? are independently selected from the group consisting of C6-C8 saturated hydrocarbons.Type: GrantFiled: September 20, 2011Date of Patent: June 3, 2014Assignee: The United States of America, as represented by the Secretary of AgricultureInventors: Zengshe Liu, Shailesh N. Shah
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Publication number: 20140140979Abstract: Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.Type: ApplicationFiled: January 18, 2013Publication date: May 22, 2014Applicant: Biosuccess Biotech Co. Ltd.Inventors: Zheng Tao Han, Hung-Fong Chen
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Publication number: 20140011873Abstract: Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.Type: ApplicationFiled: September 13, 2013Publication date: January 9, 2014Applicant: BIOSUCCESS BIOTECH CO., LTDInventors: Zheng Tao HAN, Hung-Fong CHEN
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Publication number: 20130029922Abstract: The invention provides novel compounds and formulations of turmeric oil, fish oil, aspirin and anti-cancer drugs (paclitaxel) having anti-inflammatory, analgesic and/or anti-cancer activity.Type: ApplicationFiled: June 29, 2012Publication date: January 31, 2013Applicant: ORGANOMED CORPORATIONInventor: James N. Jacob
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Patent number: 8308975Abstract: A polyol includes the reaction product of an epoxidized oil and an organic acid. The epoxidized oil and the organic acid are reacted in the presence of a Lewis base catalyst including at least one of a phosphorous atom or a nitrogen atom. The polyol is formed by a method that includes the step of reacting the epoxidized oil with the organic acid in the presence of the Lewis base catalyst.Type: GrantFiled: October 25, 2011Date of Patent: November 13, 2012Assignee: BASF SEInventors: Yeonsuk Roh, Rajesh Kumar, Cheng-Le Zhao, David Kaczan, Theodore Michael Smiecinski
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Publication number: 20120035224Abstract: The invention relates to compounds derived from betulin, and to the use thereof in plant pest control, particularly as antifeedants for butterfly larvae, beetles and snails. Further, the invention relates to novel betulin derivatives and methods for the production thereof either directly from betulin, or via intermediates derived therefrom.Type: ApplicationFiled: June 1, 2007Publication date: February 9, 2012Applicant: Valtion teknillinen tutkimuskeskusInventors: Sami Alakurtti, Jari Yli-Kauhaluoma, Taru Mäkelä, Salem Koskimies, Pia Bergström, Heikki Hokkanen, Ingeborg Menzler-Hokkanen
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Patent number: 8084631Abstract: A polyol includes the reaction product of an epoxidized oil and an organic acid. The epoxidized oil and the organic acid are reacted in the presence of a Lewis base catalyst including at least one of a phosphorous atom or a nitrogen atom. The polyol is formed by a method that includes the step of reacting the epoxidized oil with the organic acid in the presence of the Lewis base catalyst.Type: GrantFiled: May 15, 2008Date of Patent: December 27, 2011Assignee: BASF SEInventors: Yeonsuk Roh, Rajesh Kumar, Cheng-Le Zhao, David Kaczan, Theodore M. Smiecinski
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Publication number: 20110195035Abstract: The present invention relates to cosmetic and/or personal care formulations and/or compounds. In one embodiment, the present invention relates to ester compounds that can be used in various personal care formulations and/or compounds. In another embodiment, the present invention relates to branced ester compounds having a molecular weight of at least about 1,500 daltons that can be used in various personal care formulations and/or compounds.Type: ApplicationFiled: June 4, 2009Publication date: August 11, 2011Applicant: LUBRIZOL ADVANCED MATERIALS, INC.Inventors: Brian J. Vondruska, Peter Frank, Anchuu Wu
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Publication number: 20110196081Abstract: The present invention provides an ester plasticizer, particularly, a plasticizer for a polyvinyl chloride (PVC) resin, and a plastic comprising the plasticizer. More concretely, the present invention provides a plasticizer prepared by the esterification reaction of 1,4-butanediol and organic acid. When a polyvinyl chloride resin composition is manufactured using the ester plasticizer of the present invention, there are advantages in that a product having excellent plasticizing efficiency can be obtained, and in that the physical properties such as tensile strength and the like of the product are improved.Type: ApplicationFiled: August 28, 2009Publication date: August 11, 2011Inventors: Tae Wook Kwon, Hao Wang, Seung Gweon Hong, Jae Suk Koh
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Publication number: 20110183945Abstract: The invention provides a long acting curcumin derivative, preparation method and pharmaceutical use thereof, wherein said long acting curcumin derivative having the general structural formula disclosed herein, wherein R1 and R2 are hydrogen or methoxyl; R3 and R4 are each independently selected from C1-C50 alkyl. Compared with cuminoids, the inventive long acting curcumin derivative has a better release effect, a higher bioavailability and pharmaceutical activity, and thus can be useful for the treatment of diseases such as depression and cancer.Type: ApplicationFiled: September 28, 2008Publication date: July 28, 2011Applicant: BEIJING DINGGUOCHANGSHENG BIOTECH., CO., LTD.Inventors: Baoshan Ku, Weidong Zhou, Fenghua Yu, Haiyan Yao, Guangyin Yao
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Publication number: 20110028547Abstract: The present invention relates to a new use of capsiate or dihydrocapsiate, more particularly to a composition for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease or for suppressing immunity comprising capsiate, dihydrocapsiate or a pharmaceutically acceptable salt thereof as an effective ingredient. The composition and immunosuppressant of the present invention may be used for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease, and for suppressing immunity.Type: ApplicationFiled: May 27, 2008Publication date: February 3, 2011Applicant: Catholic University Industry Academic CooperationInventors: Dong Heun Shin, Young Guen Kwon, Bo Jeong Pyun, Tae-Yoon Kim
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Publication number: 20090215881Abstract: Cosmetic and therapeutic, in particular dermatological bioprecursors have the formula [A]n—PP—[B]m wherein PP is a polyphenol radical in which each hydroxyl function is protected by a group A or a group B, A is a saturated or unsaturated, substituted or unsubstituted alkyl radical having 1 to 20 carbon atoms which is bonded to the polyphenol, n is an integer not less than 1, and B is a precursor of a biologically active molecule, which is also bonded to the polyphenol, and m is an integer also not less than 1.Type: ApplicationFiled: June 16, 2006Publication date: August 27, 2009Applicants: CHANEL PARFUMS BEAUTEInventors: Sabine Delaire, Adrien Adao, Jean-Roger Desmurs, Mirjana Gelo-Pujic, Laurent Saint-Jalmes, Tarek Kassem
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Publication number: 20090170942Abstract: A compound represented by the following formula (I?) wherein X1 is a methylene group, an ethylene group, a trimethylene group or a vinylene group, X2 is a divalent group represented by the following formula A or B, Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=0 to 8, R1 and R2 are each independently a hydrogen atom, a methyl group or an ethyl group, provided that when X1 is a methylene group, then X2 is not a divalent group represented by the formula A, and when X1 is a vinylene group, then X2 is not a divalent group represented by the formula A. The compound is a stable capsinoid derivative, and is useful as an active ingredient of an external blood circulation enhancer or a cosmetic composition, a pharmaceutical composition, or a food composition.Type: ApplicationFiled: September 24, 2008Publication date: July 2, 2009Applicant: AJINOMOTO CO. INCInventors: Yusuke AMINO, Yoshinobu Takino
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Patent number: 7220710Abstract: The present invention relates to compositions which comprise mixtures of open-chain and cyclic molecules of the sugar alcohols D-sorbitol and D-mannitol which have been esterified with at least one carboxylic acid, processes for preparing these compositions and the use of this composition as lubricant or hydraulic liquid.Type: GrantFiled: July 22, 2002Date of Patent: May 22, 2007Assignees: Sudzucker Aktiengesellschaft, Fuchs Petrolub AGInventors: Markwart Kunz, Jörg Kowalczyk, Alireza Haji Begli, Rainer Kohlstrung, Manfred Harperscheid, Angela Kesseler, Rolf Luther, Theo Mang, Christian Puhl, Helena Wagner
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Patent number: 7217424Abstract: A personal care or cosmetic product composition that includes from about 0.1% to about 99% of at least one ester of alkoxylated aromatic alcohol and fatty carboxylic acid, and from about 0.1% to 60% of at least one functional ingredient is provided. The functional ingredients in the composition may include active ingredients and additional ingredients. Especially suitable active ingredients are sunscreen active ingredients and antiperspirant active ingredients. Preferred compositions are sunscreen product formulations and antiperspirant products. In one preferred embodiment, the composition further includes at least one cyclomethicone compound present in the amount of from about 1% to 99% by weight of the composition. A method of improving the protection of human or animal skin or hair from radiation and a method of improving the protection of human or animal skin or hair from perspiration are also provided.Type: GrantFiled: October 16, 2002Date of Patent: May 15, 2007Assignee: Croda, Inc.Inventors: Abel Pereira, Christopher Westergom, Patrick Obukowho
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Patent number: 6987195Abstract: Esters of alkoxylated aromatic alcohol and fatty carboxylic acid are provided. The esters are especially suitable as additives for personal care and cosmetic products. The preferred esters having an aromatic nucleus, an alkoxy spacer, an ester carboxylic group, and a fatty alkyl group, in which the aromatic nucleus and the oxygen atom of the ester carboxylic group are connected to the alkoxy spacer, and the fatty alkyl group is attached to the carbon atom of the ester carboxylic group, are also provided. Certain of the esters of alkoxylated aromatic alcohol and fatty carboxylic acid having certain skin spread factor or viscosity are also provided.Type: GrantFiled: October 16, 2002Date of Patent: January 17, 2006Assignee: Croda, Inc.Inventors: Abel Pereira, Christopher Westergom
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Publication number: 20030199655Abstract: The present invention provides a reactive diluent composition which overcomes drawbacks of both the radical-cure and the cationic-cure reactive diluents and can be applied in a broad variety of uses such as paints, inks, adhesives, pressure sensitive adhesives, surface-modifiers, and molding materials; a curable resin composition containing the same; an activated energy ray-curable resin composition; and an activated energy ray-curable ink composition for ink-jet printing.Type: ApplicationFiled: April 19, 2002Publication date: October 23, 2003Applicant: NIPPON SHOKUBAI CO., LTD.Inventors: Keiji Yurugi, Akihiko Fukada, Kenji Matsukawa
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Publication number: 20030181744Abstract: Esters of alkoxylated aromatic alcohol and fatty carboxylic acid are provided. The esters are especially suitable as additives for personal care and cosmetic products. The preferred esters having an aromatic nucleus, an alkoxy spacer, an ester carboxylic group, and a fatty alkyl group, in which the aromatic nucleus and the oxygen atom of the ester carboxylic group are connected to the alkoxy spacer, and the fatty alkyl group is attached to the carbon atom of the ester carboxylic group, are also provided. Certain of the esters of alkoxylated aromatic alcohol and fatty carboxylic acid having certain skin spread factor or viscosity are also provided.Type: ApplicationFiled: October 16, 2002Publication date: September 25, 2003Inventors: Abel Pereira, Christopher Westergom
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Publication number: 20030023104Abstract: A therapeutic compound of the chlorambucil family conjugated to two or three acyl groups derived from fatty acids. The compound has the following formula.Type: ApplicationFiled: May 24, 2001Publication date: January 30, 2003Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Robert George Whittaker, Veronika Judith Bender, Wayne Gerrard Reilly, Minoo Moghaddam
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Patent number: 6281376Abstract: A therapeutic compound of the chlorambucil family conjugated to two or three acyl groups derived from fatty acids. The compound has the following formula. in which X is chlorambucil, Y is an optional spacer group, AA is an amino acid, B is H or CH2O—R3, and n is a number from 0 to 3. X is linked to Y via the carboxyl group. R1, R2 and R3 are as defined by the present specification.Type: GrantFiled: April 12, 1999Date of Patent: August 28, 2001Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Robert George Whittaker, Veronika Judith Bender, Wayne Gerrard Reilly, Minoo Moghaddam
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Patent number: 6013813Abstract: The present invention deals with the composition of matter and the utilization of certain novel sorbitol guerbet esters which are prepared by the reaction of a guerbet acid and a sorbitol as emulsifiers.Type: GrantFiled: August 24, 1998Date of Patent: January 11, 2000Assignee: Hansotech IncInventor: Anthony J. O'Lenick, Jr.
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Patent number: 5880314Abstract: The present invention can provide cosmetic formulations comprising hydrochalcone compounds of the general formula (I): ##STR1## in which R.sup.1 to R.sup.4 are each independently H or --COR, and R is an alkyl group having 1-20 carbon atoms as effective components, which are highly effective in suppressing pigment deposition and depigmenting the skin and which are very safe to the skin and highly stable during storage.Type: GrantFiled: July 18, 1997Date of Patent: March 9, 1999Assignee: Mitsui Chemicals, Inc.Inventors: Tatsuro Shinomiya, Hiroko Kaminaga, Shohei Nozaki, Masahiro Sakamoto, Shigeharu Morimoto
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Patent number: 5808137Abstract: The present invention relates to the use of some natural or synthetic chalcones and the esters thereof with straight or branched aliphatic acids, saturated and unsaturated, containing up to 22 carbon atoms in the therapy and prevention of the uterus, ovary and breast tumors, as well as the formulations containing them. Chalcones such as isocordoin, cordoin, 2-hydroxyderricin, 2',4'-dihydroxychalcone, 4,2',4'-trihydroxychalcone have a marked affinity to the estrogen receptors of type II and an antiproliferative activity on uterus, ovary and breast tumor cell lines. These molecules proved to be useful both in therapy and in the prevention of such tumors.Type: GrantFiled: June 12, 1997Date of Patent: September 15, 1998Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Salvatore Mancuso, Franco Delle Monache
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Patent number: 5698590Abstract: Prostaglandin E.sub.1 ester derivatives of the formula (I): ##STR1## wherein the R' groups are the same as each other and are C4-12 alkyl; or cyclodextrin clathrates thereof, liposome formulations containing them, and pharmaceutical compositions containing them, as active ingredient.The compounds of formula (I) have the effect of increasing blood flow and are useful for the prevention and/or treatment of peripheral circulatory disorder, decubitus, or skin ulcers, or for the maintenance of blood flow.Type: GrantFiled: August 22, 1996Date of Patent: December 16, 1997Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Akio Nishiura, Takuya Seko, Ryoji Matsumoto, Shin-ichi Hamano
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Patent number: 5690957Abstract: Prostaglandin E, ester derivatives of the formula (I): ##STR1## wherein R is (i) --CH.sub.2 CH.sub.2 --O--CO--R.sup.1(ii) --CH.sub.2 CH.sub.2 --O--CO--CH.sub.2 --O--R.sup.2, andR.sup.1 and R.sup.2 each independently is C10-20 alkyl;and cyclodextrin clathrates thereof, liposome formulations containing them, and pharmaceutical compositions containing them as active ingredient.The compounds of formula (I) have the effect of increasing blood flow and are useful for the prevention and/or treatment of peripheral circulatory disorder, decubitus, or skin ulcers, or for the maintenance of blood flow.Type: GrantFiled: August 14, 1996Date of Patent: November 25, 1997Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Akio Nishiura, Takuya Seko, Ryoji Matsumoto, Shin-ichi Hamano
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Patent number: 5643948Abstract: Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes of the phorbol-, resiniferonol- and ingenol-classes.Type: GrantFiled: September 13, 1993Date of Patent: July 1, 1997Assignee: Procyon Pharmaceuticals, Inc.Inventors: Paul E. Driedger, James Quick
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Patent number: 5482523Abstract: Mannich condensation products prepared by the condensation of a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, hydroxy, lower alkyl or lower alkoxy; R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 is hydrogen, alkyl, phenyl, aralkyl, alkaryl, or an acyl group of the formula: ##STR2## wherein R.sub.6 is alkyl, phenyl, aralkyl or alkaryl; R.sub.7 is alkyl; u is an integer from 1 to 10; n is an integer from 5 to 100; and x is an integer from 0 to 10;with an aldehyde and a nitrogen base selected from ammonia, lower alkylamine, a polyamine and mixtures thereof.The Mannich condensation products and their fuel soluble salts are useful as fuel additives for the prevention and control of engine deposits.Type: GrantFiled: November 2, 1994Date of Patent: January 9, 1996Assignee: Chevron Chemical CompanyInventor: Richard E. Cherpeck
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Patent number: 5364948Abstract: This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compounds are also potent antifungal agents. Additionally, they inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras and are thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).Type: GrantFiled: February 9, 1993Date of Patent: November 15, 1994Assignee: Merck & Co., Inc.Inventors: Guy H. Harris, Deborah Zink, E. Tracy T. Jones, Yu L. Kong