Abstract: Novel supports useful in solid phase synthesis of oligonucleotides of the formula ##STR1## wherein .circle.P is a material selected from the group consisting of functionalized glass micropellets, silica functionalized by aminoalkyl trialkoxysilane capable of to obtain for ##STR2## Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkyl of 1 to 20 carbon atoms, saturated cycloalkyl of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x and y are an integer from 0 to 20, x.sub.1 is an integer from 1 to 20 and y.sub.1 is an integer from 0 to 10, a process for the preparation of said supports, the use of said supports and intermediates.

Abstract: A protective coating consists essentially of a polysiloxane copolymer characterized by being prepared by the reaction of a trimethyl end blocked polyamine silicone fluid including amino alkyl groups with a saturated aliphatic carboxylic acid to produce a polysiloxane copolymer including alkyl amine groups and either amide groups or amine salts or the combination thereof. The polysiloxane copolymer is utilized alone or with additives to produce a high gloss detergent resistant, and rust protective coating.

Abstract: Novel supports useful in solid phase synthesis of oligonucleotides of the formula ##STR1## wherein .circle. is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x.sub.1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.

Abstract: An improvement is provided in the compression molding of lignocellulosic composite articles, such as particle or flake board, in which polyisocyanate binder systems are employed, the improvement being the provision of a novel functional polysiloxane-hydroxyle substituted mono-carboxylic acid or metal salt-isocyanate terpolymer as a release agent on the mold surface or surfaces to give multiple release. Optionally, organopolysiloxane fluids may be employed along with the terpolymer release agent as a diluent.

Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.

Abstract: Esters and urethanes of certain polydialkylsiloxanepolyoxyalkylene block and graft copolymers which impart high voltage stabilization to dielectric olefin polymers, the stabilized olefin polymer insulating materials resulting therefrom and electric wire or cable insulated therewith.

Abstract: Modified polyamines containing carbamates, urethane and/or urea and/or thiourethane groups and having a primary amine content of from 0.1 to 20.2 wt % are produced by (a) mixing an organic isocyanate with a base in the presence of at least one hydrogen-active compound and water and (b) converting the carbamate, urethane and/or urea and/or thiourethane groups to amino groups. The isocyanate starting material has an isocyanate content of from 0.5 to 40 wt. %. The hydrogen-active compound contains a hydroxy and/or amino and/or thiol group. Water is used in a quantity such that one mol of water is present for each isocyanate equivalent. Conversion to form the amino groups is accomplished by treatment with a proton donor and/or thermal decomposition and/or solvent extraction. The polyamines thus-produced are particularly useful in the production of polyurethanes.

Abstract: Disclosed is a free-radical addition product of a mercapto-functional polyhydric alcohol and a vinyl-type silane having at least one hydrolyzable group directly attached to a silicon atom, the addition product prepared by reacting the mercapto-functional polyhydric alcohol and the vinyl-type silane in the presence of a free radical initiator. The addition product contains at least two hydroxyl groups bonded to carbon atoms and at least one silicon atom bonded to at least one hydrolyzable group.The resulting polyhydroxyl-functional addition products can be chain extended using organic polyisocyanates to produce isocyanate-terminated compounds which also contain silicon atoms directly bonded to hydrolyzable groups along the molecule chains.

Abstract: A silicone/silicate-containing antifreeze characterized by dilute aqueous stability includes substituted organosilicon carboxylates characterized by the following formula: ##STR1## wherein M is a monovalent cation such as, for example, sodium; Z represents a moiety hydrolyzable to silanol; R.sup.1 represents hydrogen, a monovalent hydrocarbon radical such as methyl, ethyl, phenyl, and the like or a substituted monovalent hydrocarbon radical; a has a value from 0 to 20, b has a value of 1 or 2, c has a value of 0 or 1, n has a value of 2, 3, or 4, and m has a value of from 3 to 15 when a is other than 0 and from about 7 to about 15 when a is 0.

Abstract: Pesticidally active compounds of the formula ##STR1## in which R.sup.1 is an organic radical,R.sup.2 is hydrogen, trialkylsilyl, a hydrocarbon or acyl radical, andR.sup.3 and R.sup.4 independently are an amino, hydroxyl, hydroximino, alkoxy or like radical.Most of the compounds are new, as are various intermediates therefor.

Abstract: Acryl functional silicone compounds are made by reacting an amine functional silicon compound with a di- or multi-functional acryl compound by a Michael-type addition reaction. These acryl functional silicone compounds are purer than others because no catalyst is used and no by-products are formed. These acryl functional silicone compounds can be used as adhesion promoters and as coating compositions which can be cured by ultraviolet radiation.

Abstract: New and more efficient chemical processes are provided for preparing (.alpha.S, 5S)-.alpha.-amino-3-chloro-2-isoxazoline-5-acetic acid (AT-125), (.alpha.S, 5S)-.alpha.-amino-3-bromo-2-isoxazoline-5-acetic acid (bromo AT-125) and the C-5 epimers thereof. The disclosed processes allow the above-mentioned antitumor agents to be produced in high yield and purity with substantially fewer steps than prior art chemical procedures.

Abstract: The reaction of dimethylformamide, R.sup.1 R.sup.2 R.sup.3 SiX and RY in the presence of zinc or the reaction of dimethylformamide, R.sup.1 R.sup.2 R.sup.3 SiX and a zinc compound RZnY.yL affords hemiaminals of formula I ##STR1## R is e.g. polyhalogenated alkyl containing at least one fluorine atom; R.sup.1, R.sup.2 and R.sup.3 are e.g. alkyl; L is a ligand; X is chlorine or bromine; Y is chlorine, bromine or iodine and y is 1 or 2.

Abstract: Organopolysiloxanes that have betaine groups and are of the general formula ##STR1## in which R.sup.1 can represent the same or different groups in the molecule and may be an alkyl radical with 1 to 18 carbon atoms, an aryl radical or a polyoxyalkylene radical with the proviso that at least 70% of the R.sup.1 radicals are methyl radicals,R.sup.2 may be the same as R.sup.1, with the proviso that at least one R.sup.2 radical represents the ##STR2## in which R.sup.3 and R.sup.4 are different, one radical representing a hydroxyl group, and the other the ##STR3## in which R.sup.5 and R.sup.6 are the same or different and represent an alkyl radical with 1 to 4 carbon atoms or a benzyl radical, and n=1, 2, or 3,x has a value of 0 to 200, andy has a value of 1 to 50,as well as processes for their synthesis and their use in cosmetic preparations.

Abstract: Novel and known functionally substituted phenoxyalkyl-, thiophenoxyalkyl- and pyridyloxyalkylsilanes are prepared by reacting substantially equimolar amounts of an alkali- or alkaline earth metal phenoxide, thiophenoxide or pyridyloxide with a haloalkylsilane under anhydrous conditions using a dipolar, aprotic solvent in combination with a liquid hydrocarbon.

Abstract: Silyl carbamates are prepared by reacting carbon dioxide with a silazane composition such as 2-methyl-2-sila-3-aza-5-hexene. The silyl carbamates may be converted to symmetrical bis(aminoalkyl)disiloxanes by hydrosilation followed by hydrolysis.

Abstract: There is provided a novel class of alkoxy silanes useful as corrosion inhibitors for metal surfaces and characterized by an alkylene group attached to silicon through a Si--C linkage. These compounds also contain nitrogen as an amine or an imine group in a linear or cyclic structure. Sulfur and/or a carbonyl or thiocarbonyl group may also be present. The invention also provides a method of inhibiting corrosion of metal surfaces by applying a coating containing or consisting of a novel silane as above described.

Abstract: In the process of preparing compounds containing silicon-carbon bonds by the hydrosilation reaction of a hydrosilyl reactant with an olefinic reactant in the presence of a soluble platinum catalyst, the improvement which comprises operating the process at a temperature below 150.degree. C. and employing, as a reaction promoter, a hydrosilyl compound whereby said hydrosilyl reactant has a composition different from the composition of said promoter and whereby said promoter provides (i) a 20% increase in the amount of silicon-carbon compounds, or (ii) a 20% increase in reaction rate relative to an unpromoted reaction.

Abstract: An external bond at the 6-position of a 3,4,5,6-tetrahydro-2H-pyran-2-one, as found in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, is readily epimerized by treating an amide of the corresponding hydroxy acid with a sulfonyl chloride reagent.

Abstract: This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C.sub.1-6 lower alkyl esters thereof. These compounds are .gamma.-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.

Abstract: Disclosed is an improved process for the production of organic polyisocyanate-based molded polymers prepared from at least one organic polyisocyanate and at least one polyol wherein there is employed an internal mold release agent comprising an amino-polysiloxane having at least one group of the formulaRNH-alkylene--O--bonded to a silicon atom of a polysiloxane, wherein R is selected from the group consisting of hydrogen, lower-alkyl, cycloalkyl, and ECHR"CHR'-- wherein E is an electron withdrawing group and R' and R" are independently selected from the group consisting of hydrogen and methyl.The molding process can be repeated many times before the mold surfaces must be cleaned or treated with release agent. The ease of release of the molded polyurethanes makes the process particularly suitable for RIM production methods.

Abstract: A class of substituted urethane acrylates and methacrylates having an aliphatic backbone is provided, the members of the class having at least one ether or polyether group with at least one pendent fluorinated organic group attached thereto. The novel compositions may be radiation polymerized, e.g., by electron beam, actinic light or heat, to a light transmissive material which is well suited to optical application, such as coupling optical fibers and light emitting diodes so as to transmit light therebetween.

Abstract: Silyl carbamates are produced by the reaction under suitable reaction conditions of silanes bearing at least one silicon-hydrogen bond of the formula: R.sub.4-x SiH.sub.x with an ammonium carbamate of the formula: R'R"NH.sub.2.sup..sym. R'R"NCO.sub.2.sup..crclbar.. This novel route is much simpler and more direct than those previously known and provides a new classes of silyl carbamates.

Abstract: Polyisocyanate addition products are made by reacting a polysiloxane having isocyanate reactive end groups, excess polyisocyanate and a compound selected from the group consisting of aliphatic alcohols, primary aliphatic amines, secondary aliphatic amines and mixtures thereof having a molecular weight of from 75 to 5000 and at least one tertiary amino group and/or oxyalkylene unit. In a preferred embodiment, the polysiloxane is reacted with excess polyisocyanate and the reaction product is subsequently reacted with the alcohol and/or amine. The addition products of this invention are particularly useful as mold release agents in the production of molded lacquer coated plastics by the "in-mold coating process.

Abstract: Stabilizers for inorganic silicate corrosion inhibitor additives in antifreeze/coolant formulations are described. The stabilizers are organosiloxanes which have ethylenediamine triacetic acid moieties as the solubilizing group. A particularly preferred stabilizer is N-(trimethoxysilylpropyl)ethylenediamine triacetic acid, ##STR1## These stabilizers help prevent the corrosion-inhibiting silicate additives from precipitating out and thus extend the shelf life of antifreeze formulations into which they are incorporated.

Abstract: A hydrogen bearing silyl carbamate of the general formula:HSiR.sub.n (O.sub.2 CNR'R").sub.3-nis synthesized from hydrogen bearing aminosilane and gaseous carbon dioxide. The resulting hydrogen bearing silyl carbamate is novel in the single hydrogen attached to the silyl carbamate and represents a major new compound for creating novel compositions of matter.

Abstract: This invention is related to homoserine aldehyde derivatives represented by the formula (I) which is important intermediate for producing mugineic acid, 2'-deoxymugineic acid, avenic acid A and homologue.

Abstract: Aromatic silanes are prepared by reacting an aromatic halogen compound with a disilane in the presence of a palladium complex and a phosphite or phosphine.The aromatic silanes obtainable by the process of the invention are valuable intermediates for the preparation of drugs, dyes and pesticides.

Abstract: Novel mildewcidal compounds of the formula (RO).sub.3 Si(CH.sub.2).sub.3 XOAr wherein R is lower alkyl, X is --NHC(O)-- or --S(CH.sub.2).sub.2 C(O)--, and Ar is aryl, and their use in latex paints.

Abstract: There are provided ultraviolet light absorbing agents of the formula ##STR1## wherein: ##STR2## Y is H or OH; Z is H, OH, OQ or OW, where at least one Z is OH if Y is H;Q is --CONH(CH.sub.2).sub.3 Si(R.sub.2).sub.x (OR.sub.1).sub.y or --COHN(CH.sub.2).sub.3 Si(R.sub.2).sub.x (OCOR.sub.1).sub.y ; andW is --C.sub.m H.sub.2m+1 ;where x=0, 1 or 2, y=1, 2 or 3, x+y=3, R.sub.1 and R.sub.2, independently, are each alkyl having 1 to 6 carbon atoms and m=1 to 18. Also provided are organopolysiloxane protective coating compositions containing said ultraviolet light absorbing agents having unique utility for protecting transparent plastic articles.

Abstract: Silicon based liquid crystal compounds produced by the reaction of an isocyanatosilane with a Schiff base, aromatic ester, azo compound or cholesteryl compound. The liquid crystals are useful in those applications in which liquid crystals are currently used and they also have the capability of being firmly chemically bonded to certain substrates, such as glass, thus avoiding the need for hermetic sealing.

Abstract: Ethylenically unsaturated polymerizable oligomers, which are particularly useful in printing plate compositions, comprise backbones formed by the removal of hydrogen from hydroxyl groups and having bonded thereto both carboxylic acid groups and ethylenically unsaturated, free radical polymerizable groups, these last two groups bonded to the backbone through the reaction of isocyanate groups.

Abstract: Organopolysiloxanes having substituted carbamoyloxy groups (.tbd.SiOCO--NH--) bonded to silicon via oxygen, which are prepared by reacting an organopolysiloxane containing Si-bonded hydroxyl groups with an organic isocyanate in the presence of an organic tin compound.The stability of the organopolysiloxanes containing carbamoyloxy groups may be improved if the organopolysiloxane having Si-bonded hydroxyl groups is reacted with an organic isocyanate in the presence of an organic tin compound which is supported on a solid carrier and then the reaction product is filtered under anhydrous conditions to remove the supported organic tin compound.

Abstract: The invention provides organosilicon compounds of the formula: ##STR1## in which: n is 1, 2 or 3;each R, which may be identical or different, is a monovalent organic group which contains a carbon-carbon double bond and from 2 to 10 carbon atoms;each R.sub.1, which may be identical or different, is a straight or branched alkyl radical optionally substituted by one or more halogen atoms or cyano groups; an aryl radical or an alkylaryl radical optionally substituted by one or more halogen atoms;R.sub.2 is a straight or branched divalent alkylene or alkylidene radical possessing up to 4 carbon atoms;X is a divalent radical consisting of, or containing, at least one hetero-atom selected from oxygen, sulphur and nitrogen atoms, the radical being attached to the radical R.sub.2 via a said hetero-atom;G is an organic radical of valency (m+1) possessing from 1 to 30 carbon atoms;m is 1, 2 or 3;and each Y, which may be identical or different, is a functional group selected from: --NO.sub.