Plural Silicons Attached By A Chain Consisting Of Oxygen And Carbon, Which Chain May Be Part Of A Ring Patents (Class 556/443)
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Patent number: 5283349Abstract: A 2,6,7-trisubstituted-3-methylenebicyclo-[3.3.0]octane of formula (I) or an enantiomer thereof, or a mixture of these in an arbitrary ratio. The compound is a key intermediate for preparation of isocarbacyclins which are useful as medicines for the circulatory system such as an antithrombotic agent, an antilipidemic agent, a hypotensive agent or an antiarterosclerotic agent.Type: GrantFiled: September 11, 1986Date of Patent: February 1, 1994Assignee: Teijin LimitedInventors: Toshio Tanaka, Kiyoshi Bannai, Seizi Kurozumi
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Patent number: 5264605Abstract: A process for preparing myoinositol polyphosphoric acid from myoinositol via a polyacylmyoinositol, a process for preparing a polysilyl-polyacylmyoinositol from a polyacylmyoinositol, and a process for preparing an optically active myoinositol polyphosphoric acid from the above product or a polysilylmyoinositol.Type: GrantFiled: February 20, 1991Date of Patent: November 23, 1993Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shoichiro Ozaki, Yutaka Watanabe
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Patent number: 5254542Abstract: Novel organic silicon compounds having a UV absorbing benzotriazole or benzophenone skeleton are provided comprising R.sup.1.sub.3 SiO.sub.1/2 and SiO.sub.2 units as essential units, 0 to 20 mol % of R.sup.2 SiO.sub.3/2 and R.sup.3.sub.2 SiO units, and 0 to 20 mol % of R.sup.3.sub.2 SiO units. The siloxane units are present in a molar ratio: (R.sup.1.sub.3 SiO.sub.1/2 +R.sup.2 SiO.sub.3/2 +R.sup.3.sub.2 SiO)/SiO.sub.2 of from 0.5 to 1.5. At least one group of formulae (1) through (7) constitutes 1 to 33 mol % of the total quantity of the organic groups represented by R.sup.1, R.sup.2 and R.sup.3 while the remainder is a monovalent saturated or unsaturated organic group or groups having 1 to 18 carbon atoms. Cosmetic compositions containing the same compounds have improved UV absorbing capacity.Type: GrantFiled: September 25, 1991Date of Patent: October 19, 1993Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Koji Sakuta, Satoshi Kuwata
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Patent number: 5247112Abstract: The present invention is a method for separating silyl ketene acetals from carbonyl by-products having a terminal olefinic bond and a boiling point similar to that of the silyl ketene acetals. The method employs a platinum catalyst which specifically effects hydrosilation of the carbonyl by-product's terminal olefinic bond by an organohydrosilane. The platinum catalyst is the reaction product of hexachloroplatinic acid and sym-tetramethyldivinyldisiloxane. In a preferred method the silyl ketene acetal is separated from the hydrosilated carbonyl by-product by distillation.Type: GrantFiled: February 8, 1993Date of Patent: September 21, 1993Assignee: Dow Corning CorporationInventors: Paul C. Dinh, Peter Y. K. Lo
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Patent number: 5216155Abstract: Silicon and aluminum complexes having the following formula I, II or III: ##STR1## wherein x is 0 or 1, T is H or ##STR2## each R is independently selected from the group consisting of H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.2-6 alkene, C.sub.6-12 aryl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.3-20 heteroaromatic, and combinations thereof, wherein R may further contain one or more atoms of a non-carbon element such as Si, Ge, Sn, P, and the like; Y is a cation, and Z is a multivalent cation, are prepared by reacting silica or alumina with a diol, in the presence of a base, while removing water formed during the reaction. Methods for producing such complexes starting with silica or alumina, and methods for converting such complexes into other silicon or aluminum-containing compounds, are disclosed.Type: GrantFiled: November 12, 1991Date of Patent: June 1, 1993Assignee: Washington Research FoundationInventors: Richard M. Laine, Kay A. Youngdahl
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Patent number: 5210247Abstract: The present invention relates to compounds of the formula ##STR1## in which Y represents an organosilicon radical;R" represents a divalent radical which connects the radical Y to the benzene ring via a chain of at least three atoms;X represents a radical of the formula --COOH, --CN, --CHO, --NH.sub.2 or --OH, in which it is possible to block the hydroxyl group with a protecting group;Z represents the same or different substituents in the 2-, 3-, 5- or 6-position to the radical X, preferably hydrogen or halogen atoms; andp represents a value of 0 to 4;and the use of these and related compounds in the preparation of compounds having liquid-crystalline properties.Type: GrantFiled: October 22, 1990Date of Patent: May 11, 1993Assignee: Consortium fur elektrochemische Industrie GmbHInventors: Norman Haberle, Wolfgang Haas, Leonhard Brader, Franz-Heinrich Kreuzer
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Patent number: 5208358Abstract: The present invention is a process for preparation of silyl ketene acetals. The process comprises contacting a mixture containing an organosilane having a silicon-bonded hydrogen (organohydrosilane) and a vinylic compound with RhCl(di-tert-butylsulfide).sub.2 as catalyst at a temperature within a range of about 20.degree. C. to 100.degree. C. The RhCl(di-tert-butylsulfide).sub.2 catalyst demonstrates higher activity than that typically described for rhodium catalysts, allowing for lower concentrations of catalyst and lower reaction temperatures to be used while maintaining high conversion to the desired silyl ketene acetals.Type: GrantFiled: July 13, 1992Date of Patent: May 4, 1993Assignee: Dow Corning CorporationInventors: Paul C. Dinh, Jeff A. Gray, Peter Y. K. Lo
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Patent number: 5189191Abstract: Bisphenols containing free-radical generating groups, such as bissilylpinacolate groups, are provided. These bisphenols can be used to make free-radical generating polycarbonate macroinitiators having thermally labile groups which can be heated with vinyl monomers, such as styrene to make polycarbonate block copolymers.Type: GrantFiled: May 15, 1992Date of Patent: February 23, 1993Assignee: General Electric CompanyInventors: Gary W. Yeager, James V. Crivello
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Patent number: 5155228Abstract: A process is described for the improved synthesis of the optically pure C.sub.10 -C.sub.18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.Type: GrantFiled: May 16, 1991Date of Patent: October 13, 1992Assignee: Merck & Co., Inc.Inventors: Todd K. Jones, Sander G. Mills, Richard Desmond
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Patent number: 5154912Abstract: The peroxides which include the O.sup.17 isotope, especially the hydrogen peroxides and peroxides and hydroperoxides prepared therefrom, are well adapted as nonradioactive labeled compounds for use in the medicinal and biological arts.Type: GrantFiled: September 20, 1990Date of Patent: October 13, 1992Assignee: AtochemInventors: Jean-Pierre Schirmann, Jean-Jacques Barieux
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Patent number: 5142081Abstract: This present invention relates to a process for the preparation of O-silylated aliphatic hydroxyl, compounds by the reaction of aliphatic hydroxyl compounds with triorganochlorosilanes and removal of the resulting gaseous hydrogen chloride from the reaction mixture, characterized in that the reaction is carried out in the presence of phase transfer catalysts in the absence of solvent.The invention also relates to the use of the O-silylated hydroxyl compounds obtained by this process as starting materials for the preparation of isocyanates containing ester groups by a reaction with isocyanato carboxylic acid chlorides.Type: GrantFiled: October 10, 1990Date of Patent: August 25, 1992Assignee: Bayer AktiengesellschaftInventors: Lutz Schmalstieg, Josef Pedain, Klaus Nachtkamp
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Patent number: 5126345Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts wherein R.sub.1 is ##STR2## R.sub.6 is hydrogen, alkyl, substituted alkyl, or aryl; and R.sub.7 and R.sub.Type: GrantFiled: February 8, 1991Date of Patent: June 30, 1992Assignee: E. R. Squibb & Sons, Inc.Inventors: William A. Slusarchyk, Robert Zahler
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Patent number: 5113003Abstract: The silicon-containing phenoxy ethers are of the formula III: ##STR1## wherein R.sup.1 and R.sup.2 which may be the same or different are selected from H, --R.sup.3 --X, aliphatic hydrocarbyl having 1-6 carbon atoms or aryl, or substituted derivatives thereof, provided that not more than one of R.sup.1 and R.sup.2 is H;R.sup.3 is a divalent C.sub.1 -C.sub.30 aliphatic and/or aromatic hydrocarbyl group which may optionally be substituted, or interrupted, by a hetero atom;R.sup.4 and R.sup.5 which may be the same or different are H, ##STR2## or an ortho para directing activating group for aromatic electrophilic substitution, other than an amine;and X is a reactive functional group capable of undergoing an acid-catalyzed electrophilic aromatic substitution reaction with a phenol, for example an aldehyde group. They can be polymerized to produce silicone-modified polymers of the phenol-aldehyde type without the use of free aldehyde.Type: GrantFiled: March 20, 1991Date of Patent: May 12, 1992Assignee: Loctite (Ireland) LimitedInventors: John G. Woods, Pauline Coakley
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Patent number: 5101032Abstract: Cycloalkylidene dyes have the formula ##STR1## where m is 0 or 1,L is a chemical bond or C.sub.1 -C.sub.2 -alkylene, which may be substituted,R.sup.1 is hydrogen, C.sub.1 -C.sub.20 -alkyl, which may be phenyl-substituted, substituted or unsubstituted phenyl, naphthyl or C.sub.3 -C.sub.7 -cycloalkyl,Y is oxygen or two hydrogens,X.sup.1 is oxygen andX.sup.2 is C.sub.1 -C.sub.8 -alkanoyloxy, substituted or unsubstituted benzoyloxy, C.sub.1 -C.sub.6 -trialkylsilyloxy or a radical of the formula OR.sup.1 or NR.sup.2 R.sup.3, where R.sup.1 is as defined above and R.sup.2 and R.sup.3 are identical or different and each is independently of the other C.sub.1 -C.sub.20 -alkyl, which may be phenyl-substituted, substituted or unsubstituted phenyl, naphthyl, or C.sub.3 -C.sub.7 -cycloalkyl or R.sup.2 and R.sup.3 together with the nitrogen atom joining them are saturated heterocyclyl, or else one of R.sup.2 and R.sup.3 is hydrogen, or X.sup.1 and X.sup.Type: GrantFiled: October 22, 1990Date of Patent: March 31, 1992Assignee: BASF AktiengesellschaftInventors: Hans-Dieter Martin, Bernhard Albert, Knut Kessel
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Patent number: 5099052Abstract: Silicon and aluminum complexes having the following formula: ##STR1## wherein x is 0 or 1, T is H or ##STR2## each R is independently selected from the group consisting of H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.2-6 alkene, C.sub.6-12 aryl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.3-20 heteroaromatic, and combinations thereof, wherein R may further contain one or more atoms of a non-carbon element such as Si, Ge, Sn, P, and the like; and Y is a cation, are prepared by reacting silica or alumina with a diol, in the presence of a base, while removing water formed during the reaction. Methods for producing such complexes starting with silica or alumina, and methods for converting such complexes into other silicon or aluminum-containing compounds, are disclosed.Type: GrantFiled: April 13, 1990Date of Patent: March 24, 1992Assignee: Washington Research FoundationInventors: Richard M. Laine, Kay A. Youngdahl, Paola Nardi
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Patent number: 5061817Abstract: The present invention relates to .beta.-lactam compound having the formula (I): ##STR1## wherein R.sup.1 is a trialkylsilyl group, dimethyl-1,1,2-trimethylpropylsilyl group, acetyl group, benzyloxycarbonyl group, O-nitrobenzyloxycarbonyl group, p-nitrobenzyloxycarbonyl group or t-butyl group, R.sup.2, R.sup.3 and R.sup.4 are a member selected from the group consisting of a lower alkyl group having 1 to 6 carbon atoms, phenyl group and an aralkyl group and a process for preparing the compound which comprises reacting enolsilylethers having the formula (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as above, with chlorosulfonylisocyanate and then reducing the obtained product. The .beta.-lactam compound of the present invention is a useful intermediate for preparing carbapenem .beta.-lactam compound.Type: GrantFiled: May 31, 1988Date of Patent: October 29, 1991Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Takeisa Ohashi, Kazunori Kan, Noboru Ueyama, Isao Sada, Akimasa Miyama, Kiyoshi Watanabe
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Patent number: 5049681Abstract: A novel optically active allyl alcohol derivative represented by the following general formulae (I), (II), (III) and (IV): ##STR1## The novel optically active allyl alcohol can be used effectively for producing leucotrienes B.sub.4 by the process of reacting an optically active halogen substituted allyl alcohol and a novel optically active acetylene-substituted allyl alcohol.Type: GrantFiled: July 8, 1988Date of Patent: September 17, 1991Assignee: Nissan Chemical Industries, Ltd.Inventor: Fumie Sato
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Patent number: 4943648Abstract: Process for preparing a silyl ketene acetal adduct, the process comprising contacting and reacting a silyl ketene acetal and an .alpha.,.beta.-unsaturated compound in the presence of a mercury- or Lewis acid-containing catalyst, for example, HgI.sub.2.Type: GrantFiled: April 1, 1988Date of Patent: July 24, 1990Assignee: E. I. du Pont de Nemours and CompanyInventor: Ira B. Dicker
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Patent number: 4918197Abstract: A method is provided for silylating aromatic acylhalide by effecting reaction between an aromatic acylhalide and halogenated polysilane in the presence of an effective amount of a supported transition metal catalyst, such as a transition metal catalyst supported by an organic or inorganic substrate.Type: GrantFiled: August 15, 1988Date of Patent: April 17, 1990Assignee: General Electric CompanyInventors: Jonathan D. Rich, Terry E. Krafft, Philip J. McDermott
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Patent number: 4886551Abstract: Compounds of the general formula ##STR1## wherein R.sup.1 is alkyl with 1 to 8 carbon atoms,R.sup.2 is --O-- or --(CH.sub.2).sub.p O--, in which p=2, 3 or 4,R.sup.3 is hydrogen, alkyl with 1 to 4 carbon atoms or acyl,n is 40 to 60m is 0 to 3,x and y being selected so that the molecular weight of the polyoxyalkylene block is 1400 to 3000 and the molar ratio of x:y is 0.8 to 2.2, are added to coating compositions, such as paint, varnish or lacquer, in amounts of 0.001 to 0.5% by weight, based on the coating composition. This improves the scratch resistance and the sliding ability of the cured coatings.Type: GrantFiled: October 6, 1987Date of Patent: December 12, 1989Assignee: Th. Goldschmidt AGInventors: Hans-Ferdi Fink, Roland Berger, Wernfried Heilen, Peter Muss
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Patent number: 4876399Abstract: The present invention is directed to novel taxols useful as a chemotherapeutic agent. Moreover, the present invention is directed to the process of preparing taxols and various intermediates in said process. A key intermediate is this process is 2,5-dihydroxy-2-patchoulenes. Therefore the present invention is also related to said intermediate and the process for its preparation.Type: GrantFiled: November 2, 1987Date of Patent: October 24, 1989Assignee: Research Corporation Technologies, Inc.Inventors: Robert A. Holton, Rouh-Rong Juo, Richard Lowenthal
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Patent number: 4827008Abstract: Alkoxysilanes containing low levels of chlorine compounds are prepared by stepwise etherification of chlorosilanes with alcohols in liquid phase and removal of the resulting hydrogen chloride by reacting the alkoxysilane obtained, which still contains a small amount of chlorine compound, with a metal alkoxide in an amount which corresponds to a small stoichiometric excess based on the proportion of chlorine compound, and freeing the reaction product from the resulting salt.Type: GrantFiled: March 8, 1988Date of Patent: May 2, 1989Assignee: BASF AktiengesellschaftInventors: Charalampos Gousetis, Knut Oppenlaender, Gert Liebold, Guenter Frey
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Patent number: 4824981Abstract: A process for the preparation of silyl ketene acetals of the formulae,R.sup.1 R.sup.2 C=C(OR.sup.3)OSiR.sub.3.sup.4 and R.sup.1 R.sup.2 C=C[OSiR.sub.3.sup.4 ].sub.2,from the reaction of a malonate compound with a triorganohalosilane in the presence of an alkali metal. The malonate compounds are dialkyl dialkylmalonates, bis(trialkylsilyl) dialkylmalonates, and dialkylmalonic acids. The triorganohalosilane is present in stoichiometric excess relative to the malonate compounds. Silyl ketene acetals are isolated and separated.Type: GrantFiled: July 6, 1987Date of Patent: April 25, 1989Assignee: Dow Corning CorporationInventors: William J. Schulz, Jr., William H. Campbell
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Patent number: 4812582Abstract: This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.Type: GrantFiled: May 6, 1987Date of Patent: March 14, 1989Assignee: The Upjohn CompanyInventor: Stephen J. Nelson
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Patent number: 4808736Abstract: In this process of the invention a compound of the formula ##STR1## wherein R is a leaving group, is reacted with a compound of the formula ##STR2## wherein R.sup.1 is an ether protecting group, and, if desired a thus-obtained compound of the formula ##STR3## is converted in a known manner into d-.alpha.-tocopherol.Type: GrantFiled: August 10, 1987Date of Patent: February 28, 1989Assignee: Hoffmann-LaRoche Inc.Inventors: Richard Barner, Josef Hubscher
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Patent number: 4791198Abstract: The present invention relates to .beta.-lactam compound having the formula (I): ##STR1## wherein R.sup.1 is a trialkylsilyl group, dimethyl-1,1,2-trimethylpropylsilyl group, acetyl group, benzyloxycarbonyl group, O-nitrobenzyloxycarbonyl group, p-nitrobenzyloxycarbonyl group or t-butyl group, R.sup.2, R.sup.3 and R.sup.4 are a member selected from the group consisting of a lower alkyl group having 1 to 6 carbon atoms, phenyl group and an aralkyl group and a process for preparing the compound which comprises reacting enolsilylethers having the formula (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as above, with chlorosulfonylisocyanate and then reducing the obtained product. The .beta.-lactam compound of the present invention is a useful intermediate for preparing carbapenem .beta.-lactam compound.Type: GrantFiled: January 6, 1987Date of Patent: December 13, 1988Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Takehisa Ohashi, Kazunori Kan, Noboru Ueyama, Isao Sada, Akimasa Miyama, Kiyoshi Watanabe
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Patent number: 4783495Abstract: ((Hydroxyphenyl)silane derivatives of the formula ##STR1## are effective in stabilizing organic materials against oxidative, thermal and actinic degradation, said derivatives being particularly effective as process stabilizers in organic materials containing phenolic antioxidants.Type: GrantFiled: November 20, 1987Date of Patent: November 8, 1988Assignee: Ciba-Geigy CorporationInventors: Stephen D. Pastor, Edward T. Hessell
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Patent number: 4767873Abstract: The invention describes a helicene compound having the structure ##SPC1##which contains seven six-membered conjugated aromatic rings capped by two five-membered rings which do not superimpose on each other.The invention also describes a helical metallocene oligomer capped by unsaturated five-membered rings, having the structure: ##SPC2##wherein M is a transition metal halide and n=1 to 100.Method for the preparation of these compounds are also presented.Type: GrantFiled: September 10, 1986Date of Patent: August 30, 1988Assignee: The Trustees of Columbia University in the City of New YorkInventors: Thomas J. Katz, Anantha Sudhakar
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Patent number: 4746750Abstract: A process is described for preparing silyl ketene acetals having the formula,(CH.sub.3)RC.dbd.C(OSiR.sup.i.sub.3).sub.2,from allyl 2-organoacrylates. The process comprises contacting an allyl 2-organoacrylate with a trisubstituted silane in the presence of a rhodium catalyst; and separating and isolating the silyl ketene acetal. Silyl ketene acetal of greater than 85-90 percent purity can be recovered.Type: GrantFiled: August 31, 1987Date of Patent: May 24, 1988Assignee: Dow Corning CorporationInventor: Anthony Revis
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Patent number: 4719262Abstract: This invention provides novel silanes and bis-silylhydrocarbons that contain a plurality of silicon-bonded alkoxy groups and at least one substituent that is bonded to silicon through oxygen and contains at least four carbon atoms, two of which form a terminal group of the formula CH.sub.2 .dbd.CH--. A preferred class of these compounds will cohesively bond polyorganosiloxane elastomers and resins to both organic and inorganic substrates.Type: GrantFiled: November 28, 1986Date of Patent: January 12, 1988Assignee: Dow Corning CorporationInventor: Edwin P. Plueddemann
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Patent number: 4709054Abstract: A method is provided for silylating organic substrates, utilizing a halogenated polysilane, such as 1,1,2,2-tetrachloro dimethyldisilane and an aromatic acyl halide, for example, trimellitic anhydride acid chloride in the presence of a transition metal catalyst.Type: GrantFiled: August 13, 1985Date of Patent: November 24, 1987Assignee: General Electric CompanyInventor: Jonathan D. Rich
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Patent number: 4691039Abstract: Ethoxylated siloxane surfactants, and mixtures of such surfactants with curable silicone prepolymers. The mixtures are hydrophilic after cure, have semipermanent hydrophilicity, and are especially useful as dental impressions.Type: GrantFiled: November 15, 1985Date of Patent: September 1, 1987Assignee: Minnesota Mining and Manufacturing CompanyInventors: Steven M. Aasen, Thomas T. Bryan
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Patent number: 4659851Abstract: This invention provides novel silanes and bis-silylhydrocarbons that contain a plurality of silicon-bonded alkoxy groups and at least one substituent that is bonded to silicon through oxygen and contains at least four carbon atoms, two of which form a terminal group of the formula CH.sub.2 .dbd.CH--. A preferred class of these compounds will cohesively bond polyorganosiloxane elastomers and resins to both organic and inorganic substrates.Type: GrantFiled: March 26, 1986Date of Patent: April 21, 1987Assignee: Dow Corning CorporationInventor: Edwin P. Plueddemann
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Patent number: 4658044Abstract: Compounds of formula (C) ##STR1## where either R.sup.D represents a hydroxymethyl group and R.sup.E represents a hydroxyl group or R.sup.D represents a protected hydroxymethyl group and R.sup.E represents a protected hydroxyl group or R.sup.E represents a hydroxyl group and R.sup.D represents an ethenyl group and R.sup.F represents a hydroxyl or protected hydroxyl group or a leaving group with the proviso that either R.sup.D represents a protected hydroxymethyl group and R.sup.E represents a protected hydroxyl group or R.sup.F represents a protected hydroxyl group, which compounds are of use as intermediates in the preparation of compounds having antiviral activity.Type: GrantFiled: October 24, 1985Date of Patent: April 14, 1987Assignee: Glaxo Group LimitedInventor: Paul Ravenscroft
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Patent number: 4617411Abstract: This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E.sub.2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypertensive activity. In addition the invention also discloses certain novel trialkylsilyl acetylenic intermediates.Type: GrantFiled: March 25, 1985Date of Patent: October 14, 1986Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Richard M. Weier
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Patent number: 4599439Abstract: Analogs of arachidonic acid are provided having the structure ##STR1## wherein R is CH.sub.2 OH or CO.sub.2 H and m is 1 or 2. These compounds are useful as inhibitors of leukotriene and prostaglandin biosynthesis and as such are useful an antiallergy and antiinflammatory agents.Type: GrantFiled: August 6, 1984Date of Patent: July 8, 1986Assignee: E. R. Squibb & Sons, Inc.Inventor: Raj N. Misra
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Patent number: 4585885Abstract: A silyl-enol ether of the formula ##STR1## wherein n stands for the number and X stands for a group ##STR2## or n stands for the number 1 and X stands for the 6,11-dimethylhexadeca-2,4,6,8,10,12,14-heptaene-2,15-diyl group, the symbols R.sup.1 have the same or different significances and denote alkyl groups, and the symbol R.sup.2 represents a trialkylsiloxy group --OSi(R.sup.1).sub.3 or an ether group,is oxidized with percarboxylic acid and, if desired, the resulting .alpha.-siloxy ketone is hydrolyzed to an .alpha.-hydroxy ketone. This process is especially suitable for the manufacture of astaxanthin.Type: GrantFiled: August 19, 1983Date of Patent: April 29, 1986Assignee: Hoffmann-La Roche Inc.Inventors: Kurt Bernhard, Robert K. Muller, Robert Spruijtenburg
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Patent number: 4535174Abstract: Free-radical initiators are provided in the form of silylethers of arylpinacols. An aryl ketone is reacted with a monohalo- or dihalosilane having at least one olefinically unsaturated organic radical attached to silicon in the presence of an active metal reducing agent, such as magnesium.Type: GrantFiled: November 2, 1984Date of Patent: August 13, 1985Assignee: General Electric CompanyInventor: James V. Crivello
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Patent number: 4529812Abstract: This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E.sub.2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypertensive activity. In addition the invention also discloses certain novel trialkylsilyl acetylenic intermediates.Type: GrantFiled: December 6, 1983Date of Patent: July 16, 1985Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Richard M. Weier
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Patent number: 4415747Abstract: This process is concerned with the reductive coupling of .alpha.-halo ethers and/or .alpha.-halo esters to make ethylene glycol derivatives by carrying out the reductive coupling process in the presence of an iron compound having iron in an oxidation state of zero.Type: GrantFiled: September 29, 1981Date of Patent: November 15, 1983Assignee: Union Carbide CorporationInventor: Leonard Kaplan
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Patent number: 4304934Abstract: This invention relates to a method of synthesizing 3-amino-2-hydroxy-2-cyclopentenones possessing an aliphatic substituent in the 4-position which comprises reacting cyanoacetamide with an aliphatic aldehyde to yield the corresponding .beta.-substituted-.alpha.,.alpha.'-dicyanoglutaramide, hydrolyzing the amide to the corresponding .beta.Type: GrantFiled: December 30, 1980Date of Patent: December 8, 1981Assignee: Polaroid CorporationInventors: James R. Bartels-Keith, Eva R. Karger, Jean B. Rogers
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Patent number: 4288603Abstract: Accelerators useful for the cure of epoxy resin compositions are derived from the silylation of substituted catechol derivatives.Type: GrantFiled: July 14, 1980Date of Patent: September 8, 1981Assignee: General Electric CompanyInventor: Charles J. Stark, Jr.
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Patent number: 4269780Abstract: A process for forming non-polymeric disproportionation products of non-conjugated olefins using catalysts comprising (1) at least one of certain neutral carbene complexes, and (2) at least one of certain compounds of Groups IVa, IVb, Vb, VIb, VIIb, VIII, and Ib of the Periodic Table of the Elements.Type: GrantFiled: December 6, 1979Date of Patent: May 26, 1981Assignee: Phillips Petroleum CompanyInventor: Dennis S. Banasiak
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Patent number: 4252967Abstract: Dihaloneopentyl silicates are solid compositions formed by esterification of silicon halides or silicate esters with dihaloneopentyl glycol. These compositions are useful as flame retardants in plastic formulations.Type: GrantFiled: June 20, 1979Date of Patent: February 24, 1981Assignee: Stauffer Chemical CompanyInventors: Alfred K. Jung, Michael Turczyk, Edward D. Weil
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Patent number: 4235797Abstract: Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the F.sub.2 series.Type: GrantFiled: April 17, 1979Date of Patent: November 25, 1980Assignee: American Cyanamid CompanyInventor: Allan Wissner
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Patent number: 4226794Abstract: Novel surface active agents are disclosed having the formula: ##STR1## wherein R is hydrogen, an alkyl, alkenyl, aryl or aralkyl group; each R' is independently selected from the same group as R with the proviso that at least a majority of R' radicals attached to each Si atom are sterically hindered alkyl groups having at least 3 carbon atoms; each R''' independently is selected from hydrogen or methyl; and n is an integer of from about 10 to about 75.Type: GrantFiled: May 21, 1979Date of Patent: October 7, 1980Assignee: Olin CorporationInventors: Michael Scardera, David F. Gavin
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Patent number: 4202822Abstract: Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the F.sub.1 series.Type: GrantFiled: December 8, 1977Date of Patent: May 13, 1980Assignee: American Cyanamid CompanyInventor: Allan Wissner