Abstract: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making block copolypeptides and related protocols for adding aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains by exposing the NCA to solutions containing polyaminoacid chains having an amido amidate metallacyle end groups and reacting the NCA with the amido containing metallacyle end group so that the NCA is added to the polyaminoacid chain. Addition methods include means of controlling the addition of aminoacid-N-carboxyanhydrides to polyaminoacid chains by reacting NCAs with initiator molecules and allowing initiator complexes to open the ring of the NCAs through oxidative addition across either the O—C5 or O—C2 anhydride bond resulting a controlled polypeptide polymerization. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

Abstract: A thermal cutoff member and compositions used to manufacture such members are described herein as including at least two organic compounds which, when sufficiently combined, give rise to a component which has a lower melt transition temperature than the initial organic compounds prior to combining the same. The thermal cutoff member is generally utilized in a thermal cutoff construction having an electrical switching unit that changes its operating condition when the member therein melts by being heated to a certain temperature for the particular material that forms the member being utilized.

Abstract: Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods of preparing (±)-cis-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol, are disclosed herein. In one embodiment, the (±)-2-((dimethylamino)methyl)cyclohexanone and transition-metal salt are in the form of a (±)-2-((dimethylamino)methyl)cyclohexanone:transition-metal salt complex. In another embodimemt, aryl is 3-methoxyphenyl.

Abstract: The present invention relates to a method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.

Abstract: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making self assembling amphiphilic block copolypeptides and related protocols adding oligo(ethyleneglycol) functionalized aninoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex, thereby forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

Abstract: Chelating agents (chelants) of the general structure: wherein: n=2-4 whereby at least two of X are of formula III Y=COOH, —PO3H2 or o-hydroxyphenyl R1, R2 and R3 are independently H or C1-C8 alkyls m=1, 2 or 3 and most preferably m=1 Z and Z1 are unsubstituted or substituted C C+=C or CH or N Z1, Z2, Z′1, and Z′2 are independently selected from H (or nothing for Z2 and Z′2 if C* is N) and C1-C10 groups that optionally contain one or more N atoms (optionally attached directly to C*), whereby one of the pairs Z/Z1, Z/Z2 and Z1/Z2 and one of the pairs Z′/Z′1, Z′1/Z′2 and Z′1/Z′2 may be connected to form substituted or unsubstituted (hetero)(poly)cyclic structures of less than 20 atoms C* is either part of an aromatic (hetero)(poly)cyclic structure or linked by a double bond to Z or Z2 and/or Z′ or Z′2.

Abstract: The present invention relates to a novel, heterogeneous catalyst which is suitable, in particular, for olefin metathesis. This catalyst is immobilized on an inorganic support and contains at least one active rhenium compound containing at least one carbene group and, if desired, further functional groups. The rhenium compound is bonded to the material used as support by a chemical bond.

Abstract: Compounds of the following formula are suitable as activators for peroxy compounds in laundry detergents and cleaning products: [LnMmXp]zYq  (1) in which M is manganese in oxidation stage II, III, IV, V and/or VI or cobalt in oxidation stage II and/or III, X is a coordination group or bridging group, Y is a counterion in the corresponding stoichiometric amount to balance a charge z present, where z as the metal complex charge, can be positive, zero or negative, n and m, independently of one another, are integers of from 1 to 4, p is an integer from 0 to 15, q is z/charge of Y L is a ligand of the formula (2) in which substituents R1 to R8 are as defined in the description.

Abstract: This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease associated with cell or tissue damage produced by free radicals, such as superoxide.

Abstract: New ligands having a backbone comprised of NCCX can be combined with a metal or metal precursor compound or formed into a metal-ligand complex to catalyze a number of different chemical transformations, including polymerization.

Abstract: This invention relates to the synthesis of certain complexes of cysteine, N-acetylcysteine, N-(2-mercaptopropionyl)glycine, and L-2-oxothiazolidine-4-carboxylate and to the nutritional use of these and other related individual or complexed thiol-contributing glutathione predecessors. Clinical uses for these molecules and complexes in the beneficial modification of various physiological conditions and functions associated with aging, chronic glaucoma, diabetes mellitus, insulin resistance, macular degeneration, neurodegenerative diseases and vasoconstriction are described in particular.

Abstract: Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include chiral C1-C6 TunaPhos ligands. The ruthenium TunaPhos complex reduces ketones to the corresponding alcohols with 95-99.6% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.

Abstract: The present invention relates to catalyst systems, processes for making such catalysts, intermediates for such catalysts, and olefin polymerization processes using such catalysts wherein such catalyst includes a component represented by the following formula 1A: wherein R and R′ independently represent a hydrogen atom, or a substituted or unsubstituted, branched or unbranched hydrocarbyl or organosilyl radical; R1, R2, and R3 independently represent a hydrogen atom, or a substituted or unsubstituted, branched or unbranched hydrocarbyl radical; M is a group IIIB, IVB, VB, VIB, VIIB or VIII transition metal; T independently represents a univalent anionic ligand such as a hydrogen atom, or a substituted or unsubstituted hydrocarbyl halogeno, aryloxido, arylorganosilyl, alkyloriganosilyl, amido, arylamido, phosphido, or arylphosphido group, or two T groups taken together represent an alkylidene or a cyclometallated hydrocarbyl bidentate ligand; L independently represents a sigma donor

Abstract: Laundry detergents and cleaners which, in addition to a peroxide compound, comprise a compound of the formula (R1R1)N—X—N(R1R1)  (I) or metal complexes thereof, where X and R1 have the meanings listed in the description, are claimed.

Abstract: Ionic perfluorovinyl compounds and their uses as components of ionic conductors of the polymer type, of selective membranes or of catalysts. The compounds comprise at least one perfluorovinyl group and at least one group chosen from —O or one of the groups C≡N, —C(C≡N)2, —NSO2R or —C[SO2R]2 or a pentacyclic group comprising at least one N, C—C≡N, CR, CCOR or CSO2R group. The compounds and/or their polymers are of use in the preparation of ionically conducting materials, electrolytes and selective membranes.

Abstract: In the presence of (1) an oxidation catalyst comprising a crystalline complex of manganese with an N,N′-disalicylidenediamine (e.g. N,N′-disalicylidene C2-8 alkylenediamines and N,N′-disalicylidene C6-12 arylenediamines), or (2) an oxidation catalyst comprising the above complex and a basic nitrogen-containing compound, a substrate (e.g., &bgr;-isophorone or a derivative thereof) is oxidized with molecular oxygen to produce a corresponding oxide (e.g., ketoisophorone). Ketoisophorone can be obtained from &bgr;-isophorone with high conversion and high selectivity.

Abstract: Chelating agents (chelants) of the general structure: wherein: n=2-4 X=—CR1R2—, or whereby at least two of X are of formula III Y=COOH, —PO3H2 or o-hydroxyphenyl R1, R2 and R3 are independently H or C1-C8 alkyls m=1, 2 or 3 and most preferably m=1 Z and Z1 are unsubstituted or substituted C C*=C or CH or N Z1, Z2, Z′1, and Z′2 are independently selected from H (or nothing for Z2 and Z′2 if C* is N) and C1-C10 groups that optionally contain one or more N atoms (optionally attached directly to C*), whereby one of the pairs Z/Z1, Z/Z2 and Z1/Z2 and one of the pairs Z′/Z′1, Z′1/Z′2 and Z′/Z′2 may be connected to form substituted or unsubstituted (hetero)(poly)cyclic structures of less than 20 atoms. C* is either part of an aromatic (hetero)(poly)cyclic structure or linked by a double bond to Z or Z2 and/or Z′ or Z′2.

Abstract: Chloropentafluorobenzene or bromopentafluorobenzene is formed by heating perhalobenzene, C6FnX6-n where n is 0 to 4, and each X is, independently, a chlorine or bromine atom, with alkali metal fluoride, and an aminophosphonium catalyst (e.g., (Et2N)4PBr). The resultant chloropentafluorobenzene or bromopentafluorobenzene can be converted into a pentafluorophenyl Grignard reagent or a pentafluorophenyl alkali metal compound. This in turn can be converted into tris(pentafluorophenylborane), which can be converted into a single coordination complex comprising a labile tetra(pentafluorophenyl)boron anion (e.g., a trialkylammonium tetra(pentafluorophenyl)boron complex or an N,N-dimethylanilinium tetra(pentafluorophenyl)boron complex).

Abstract: Compounds of the formula (R1R1)N—X—N(R1R1)  (I) are claimed, where R1 and X have the meanings given in the description.

Abstract: Radioimaging agents, which exhibit high uptake and retention in the myocardium are disclosed.

Abstract: ORGANOMETALLIC COORDINATION complexes exhibiting two separate, stable forms are described. Conversion from one form to the other is intramolecular, reversible, light-activated (a molecular switch) and occurs both in the solid and in solution. The two forms differ in photochemical and electrochemical characteristics (different colors and reduction potentials). The complexes can be used in information storage and for light-gathering, light-emitting, sensing and detecting applications.

Abstract: The subject invention provides a binuclear metal complex having structure (I) wherein M1, and M2 are independently selected from the group consisting of Fe, Co, Mn and Ru; wherein m and n are independently +2 or +3; wherein R1, R2, R3, R4, R5 and R6 are independently a linear C1-C6 alkyl, C5-C6 cycloalkyl, phenyl, etc.; wherein (i) R1 and R2, (ii) R3 and R4, or (iii) R5 and R6 independently and optionally are linked covalently and together with the respective adjoining C atom comprise a spirocyclic ring; wherein i, j and k are integers such that 2≦i+j+k≦4; wherein p is 1 or 2, and q is 0, 1 or 2 such that m+n−4=p×q; wherein (i) R1 or R2 and R3 or R4, (ii) R3 or R4 and R4 or R5, or (iii) R1 or R2 and R5 or R6 independently and optionally are linked covalently and together with the respective adjoining C atoms comprise a fused ring; wherein Ar is 1,2-phenylene, 1,2- or 2,3-naphthylene, etc.

Abstract: Laundry detergents and cleaners which, in addition to a peroxide compound, comprise a compound of the formula (R1R1)N—X—N(R1R1)  (I) or metal complexes thereof, where X and R1 have the meanings listed in the description, are claimed.

Abstract: Chemical vapor deposition processes utilize as precursors volatile metal complexes with ligands containing metalloid elements silicon, germanium, tin or lead.

Abstract: Methods of forming metal alkoxides and methods of forming precursor solutions of metal alkoxides suitable for the coating of glass in the manufacture of electrochromic devices are disclosed. The method of forming metal alkoxides involves dissolving the metal halide in an anhydrous solvent and reacting it with an alcohol and (together with the addition of the alcohol or subsequently) adding an epoxide, and then evaporating-off the volatile components of the reaction product to leave a solid metal alkoxide that is substantially free of halide. The alkoxide may then be dissolved in a solvent including an alcohol (preferably ethanol) containing a small proportion of water to produce a precursor solution suitable for coating glass, the coating then being hydrolyzed to form a sol-gel and then baked to remove volatile components and to yield a thin layer of metal oxide.

Abstract: Volatile metal complexes with &agr;-sila-&bgr;-diketonate ligands containing haloalkyl, and particularly, perfluoroalkyl, substitutents are useful as metal precursors for chemical vapor deposition processes and as nanostructured materials containing fluorous domains.

Abstract: In the presence (1) an oxidation catalyst comprising a crystalline complex of manganese with an N,N′-disalicylidenediamine (e.g. N,N′-disalicylidene C2-8 alkylenediamines and N,N′-disalicylidene C6-12 arylenediamines), or (2) an oxidation catalyst comprising the above complex and a basic nitrogen-containing compound, a substrate (e.g., &bgr;-isophorone or a derivative thereof) is oxidized with molecular oxygen to produce a corresponding oxide (e.g., ketoisophorone). Ketoisophorone can be obtained from &bgr;-isophorone with high conversation and high selectivity.

Abstract: The invention relates to novel targeting drug agents that are targeted for entry into the mitochondria. More specifically, the agents are cisplatin derivatives called mitoplatins which are useful as anti-tumor agents. Mitoplatins are named for their targeting to the mitochondrial DNA via the carnitine-acylcarnitine translocase system. The invention also relates to methods of synthesizing mitoplatins, compositions of matter containing mitoplatins and methods of using the mitoplatins.

Abstract: Highly reactive, stable tetramanganese-oxo cubane complexes, their synthesis and their use as a functional catalyst for in vitro O2 production. Preferred complexes are i) a tetramanganese-oxo cubane complex having the formula L6Mn4O4, wherein Mn4O4, is a cubane core and L6 are six facially-capping bidentate ligands bridging between the Mn atoms; ii) a manganese-oxo-pyramid complex having the formula L6Mn4O3, wherein Mn4O3, is a pyramidal core and L6 are six bidentate ligands bridging between the Mn atoms; and iii) a manganese-oxo-butterfly complex having the formula L6Mn4O2 or L5Mn4O2, wherein Mn4O2, is a butterfly core and L6or L5 are six or five bidentate ligands bridging between the Mn atoms. Preferred ligands are carboxylate, phosphinate or diphenylphosphinate ligands. These catalysts may be used for the oxidation of water to oxygen and hydrogen peroxide and may also be used to catalyze the oxidation of chloride and simple chloride compounds to chlorine gas.

Abstract: The present invention relates to a process for preparing 3,5, 5-trimethylcyclohex -2-ene-1,4-dione (oxoisophorone; OIP) by oxidation of 3,5,5-trimethylcyclohex-3-en-1-one (&bgr;-isophorone, &bgr;-IP) with molecular oxygen in the presence of a solvent, of a base and of a manganese salen derivative as catalyst.

Abstract: The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.

Abstract: In the presence of (1) an oxidation catalyst comprising a crystalline complex of manganese with an N,N′-disalicylidenediamine (e.g., N,N′-disalicylidene C2-8 alkylenediamines and N,N′-disalicylidene C6-12 arylenediamines), or (2) an oxidation catalyst comprising the above complex and a basic nitrogen-containing compound, a substrate (e.g., &bgr;-isophorone or a derivative thereof) is oxidized with molecular oxygen to produce a corresponding oxide (e.g., ketoisophorone). Ketoisophorone can be obtained from &bgr;-isophorone with high conversion and high selectivity.

Abstract: The preparation of organomagnesium compounds from organic halides, especially aromatic chloro compounds, and magnesium metal in the presence of a transition metal compound as a catalyst.

Abstract: Chemical vapor deposition processes utilize as precursors volatile metal complexes with ligands containing metalloid elements silicon, germanium, tin or lead.

Abstract: Compounds of the following formula are suitable as activators for peroxy compounds in laundry detergents and cleaning products:[L.sub.n M.sub.m X.sub.p ].sup.z Y.sub.q (1)in whichM is manganese in oxidation stage II, III, IV, V and/or VI or cobalt in oxidation stage II and/or III,X is a coordination group or bridging group,Y is a counterion in the corresponding stoichiometric amount to balance a charge z present, wherez as the metal complex charge, can be positive, zero or negative,n and m, independently of one another, are integers of from 1 to 4,p is an integer from 0 to 15,q is z/charge of YL is a ligand of the formula (2) ##STR1## in which substituents R.sup.1 to R.sup.8 are as defined in the description.

Abstract: The manganese complex of the invention is one represented by the formula (1 )[Mn(H.sub.2 NNHCONH.sub.2).sub.3 ](NO.sub.3).sub.2 (1)and showing weight loss of not higher than 1% after heating at 107.degree. C. for 400 hours. The manganese complex has high heat stability and is used as an active component of an air bag gas generating composition. The air bag gas generating composition of the invention contains the above-mentioned manganese complex. The air bag gas generating composition comprising a complex mixture of the manganese complex and magnesium complex of semicarbazide and/or carbohydrazide features a high rate of combustion residue in an inflator.

Abstract: The present invention relates generally to carriers for transport of amino acid, amino acid derivatives and other biologically important molecules such as catecholamines and neurotransmitters. In particular, the present invention relates to ditopic receptor molecules that contain salicylaldimine and crown-ether subunits, and complexed to metal ions. The compounds of the present invention were shown to have efficient transport properties for zwitterions.

Abstract: In a process for the telomerization of dienes with nucleophiles in a liquid two-phase system, use is made as catalysts of complexes comprising a transition metal as central atom and at least one tris-(hydroxyalkyl)-phosphine or -phosphine oxide as ligand. The use as catalysts of compounds comprising a transition metal as central atom and at least one tris-(hydroxy-C.sub.2 -C.sub.5 -alkyl)-phosphine or -phosphine oxide as ligand, new compounds of this type and aqueous solutions of such compounds are likewise described.

Abstract: Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzheimer's disease in a mammal, for monitoring the response to a therapy in a mammal having Alzheimer's disease, for identifying an agent useful for treating Alzheimer's disease, for treating Alzheimer's disease, and for detecting the presence of the infectious form of the prion protein, are also described.

Abstract: The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.

Abstract: Metal alkoxyalkoxidecarboxylates wherein the alkoxy portion has 2-6 carbon atoms and the alkoxide portion has 2-6 carbon atoms are provided and are useful in forming films on a substrate.

Abstract: Compounds of the following formula are suitable as activators for peroxy compounds in laundry detergents and cleaning products:[L.sub.n M.sub.m X.sub.p ].sup.z Y.sub.q (1)in whichM is manganese in oxidation stage II, III, IV, V and/or VI or cobalt in oxidation stage II and/or Ill, and iron in oxidation stage II and/or III,X is a coordination group or bridging group,Y is a counterion in the corresponding stoichiometric amount to balance a charge z present, wherez as the metal complex charge can be positive, zero or negative,n and m, independently of one another, are integers from 1 to 4,p is an integer from 0 to 15,q is z/charge of Y andL is a ligand of the formula (2) ##STR1## in which substituents R.sup.1 to R.sup.8 are as defined in the description, and A is a C.sub.2 -C.sub.4 -alkylene, C.sub.5 -C.sub.10 -cycloalkylene or amino group.

Abstract: The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a monothiourea (MTU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.

Abstract: Metal complexes of the formula 1[L.sub.n M.sub.m X.sub.p ].sup.z Y.sub.q (1)whereM is manganese in oxidation state II, III, IV, V and/or VI or cobalt in oxidation state II and/or III or iron in oxidation state II and/or III,X is a coordinating or bridging group,Y is a counterion in the appropriate stoichiometric amount to compensate an existing charge z, wherez as the charge of the metal complex can be positive, zero or negative, n and m independently of one another are integers from 1 to 4,p is an integer from 0 to 15,q is z/charge of Y, andL is a ligand of the formula (2), (3) or (4) ##STR1## and A and R.sup.1 to R.sup.8 are as defined in the description.

Abstract: The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a thioacetamidethiourea (TATU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.

Abstract: A method is provided for preparing organic hydroperoxides by oxidizing aryl alkyl hydrocarbons having a benzylic hydrogen with an oxygen containing gas using as a catalyst an oxo (hydroxo) bridged tetranuclear metal complex having a mixed metal core, one metal of the core being a divalent metal selected from Zn, Cu Fe, Co, Ni, Mn or mixtures thereof and another metal being a trivalent metal selected from In, Fe, Mn, Ga, and Al.

Abstract: It is possible to modify the rac/meso ratio of a rac/meso mixture in a stereorigid, bridged metallocene compound by subjecting a rac/meso isomeric mixture directly obtained from the synthesis to selective decomposition of the undesired isomer in the presence of compounds having either acidic hydrogen atoms or reactive halogen atoms. This process allows to prepare chiral metallocenes in their pure racemic or meso isomeric form.

Abstract: Catalyst systems which comprise a transition metal and a pyrophosphite ligand are particularly effective as catalysts for hydrosilation reactions. The transition metal is from groups 7-11 of the Periodic Table, and the pyrophosphite has the following formula: ##STR1## wherein E and E' are independently a direct bond, --S--, --Se--, or --CR.sub.9 R.sub.10 -- where R.sub.9 and R.sub.10 are independently hydrogen or alkyl of 1-18 carbon atoms, and R.sub.10 can also be phenyl. R is H or methyl, R.sub.1-8 are independently H, C.sub.1-18 alkyl, C.sub.5-12 cycloalkyl, or C.sub.7-15 phenylalkyl.

Abstract: Proposed is a method for the preparation of an ionic polyhalogeno metal complex compound consisting of a tetraalkylammonium cation and a polyhalogeno metal anion, of which the metal is selected from those having an atomic valency of 1 and a coordination number of 2, those having an atomic valency of 3 and a coordination number of 4 and those having an atomic valency of 2 and a coordination number of 4. The method comprises the steps of: dissolving a tetraalkylammonium halide and elementary halogen in a stoichiometric proportion corresponding to the chemical composition of the desired complex compound in an organic solvent to form a solution; dissolving, in the solution, the metal in an amount larger than the stoichiometric amount so as to be dissolved in the solution forming the complex compound in the reaction mixture; removing the undissolved metal from the reaction mixture to give a solution of the complex compound; and isolating the complex compound from the solution.

Abstract: This invention provides salen-manganese complexes and pharmaceutically acceptable compositions thereof useful as antioxidants and free radical scavengers.