Rotating Cutting Reel Patents (Class 56/231)
  • Recombinant vaccine for diseases caused by encapsulated organisms
    Patent number: 6086894
    Abstract: Vaccines for diseases caused by normally encapsulated organisms are produced by genetically modifying those organisms by deleting the genes encoding for capsule synthesis or a portion thereof sufficient to produce non-capsulated mutants of the organisms. As an example, a live, attenuated strain of Actinobacillus pleuropneumoniae genetically modified with a large deletion in a chromosomal regions of the DNA which encodes for capsule synthesis is a safe and effective vaccine against swine pleuropneumonia.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: July 11, 2000
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Thomas J. Inzana, Christine Ward