Plural Rings In Alcohol Moiety Patents (Class 560/194)
-
Publication number: 20110130450Abstract: The present invention provides a method for the purification of pravastatin comprising extracting a solution comprising pravastatin in a water-immiscible solvent with water at a pH value ranging from 5.0 to 7.0.Type: ApplicationFiled: March 31, 2009Publication date: June 2, 2011Inventors: Aad Johannes Bouman, Robertus Mattheus De Pater, Piotr Wnukowski
-
Publication number: 20110101269Abstract: The present invention relates to a liquid-crystal (LC) display of the PS (polymer stabilised) or PSA (polymer sustained alignment) type, and to polymerisable compounds and LC media for use in PS (polymer stabilised) and PSA displays.Type: ApplicationFiled: July 31, 2008Publication date: May 5, 2011Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Georg Bernatz, Andreas Taugerbeck
-
Publication number: 20110081393Abstract: Disclosed is a cooling sensation agent composition or sensory stimulation agent composition which contains at least one of diester compounds of dicarboxylic acid represented by the formula (1) wherein A represents CH2 or CH?CH, n represents an integer of 0 to 4 when A is CH2, or 1 when A is CH?CH, B is an alcohol residue having 10 to 18 carbon atoms and containing a para-menthane skeleton, which may have a substituent, and C is an alcohol residue having 6 to 18 carbon atoms, which may have a substituent as well as a flavor or fragrance composition, a beverage, a food product, a perfume or cosmetic product, a toiletry product, daily utensil products or groceries, a fiber, a fiber product, clothes, clothing or a medicine, wherein the cooling sensation agent composition or the sensory stimulation agent composition is compounded.Type: ApplicationFiled: October 6, 2010Publication date: April 7, 2011Inventors: Yasuhiro Komatsuki, Tomoko Yamamoto, Takashi Aida, Kenya Ishida
-
Publication number: 20110077251Abstract: The invention relates to 17? lupane derivatives of formula (I): wherein R1 and X are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infection by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.Type: ApplicationFiled: August 16, 2010Publication date: March 31, 2011Inventors: Christophe Moinet, Bingcan Liu, Liliane Halab, Nathalie Turcotte, Real Denis, Carl Poisson, Paul Nguyen-Ba, Monica Bubenik, Laval Chan Chun Kong
-
Publication number: 20110069241Abstract: A liquid crystal compound having a good durability against light, a polymerizable liquid crystal composition and an optically anisotropic material are provided. Further, an optical element having a good durability against light and an optical information writing/reading device employing such an element are provided. The liquid crystal compound is represented by a general formula CH2?CR1—COO-(L)k-E1-E2-(E3)m-R2. E1 is preferably a trans-2,6-decahydronaphthalene group and E2 is preferably a trans-1,4-cyclohexylene group. A phase difference plate 4 produced by employing the compound has a good durability against light, and accordingly, it is possible to achieve an optical head device employing a blue laser as a light source 1 and being suitable for large capacity writing/reading.Type: ApplicationFiled: December 2, 2010Publication date: March 24, 2011Applicant: ASAHI GLASS COMPANY, LIMITEDInventors: Satoshi Okada, Makoto Hasegawa, Hiroshi Kumai
-
Publication number: 20110063966Abstract: A compound having a good durability against light and capable of producing desired liquid crystallinity after polymerization, and a polymerizable liquid crystal composition containing such a compound, are provided. Further, an optical element having a good durability against light, and an optical information writing/reading device employing such an element, are provided. A compound represented by CH2?CR1—COO—R2-Cy-Ph-R3—OCO—CR4?CH2. R1 and R4 are each preferably a hydrogen atom. R3 is preferably a C1-6 alkylene group wherein an oxygen atom is present or not present at an end of the group to be bonded to a cyclic group, and wherein some or all of hydrogen atoms bonded to carbon atoms in the group may be substituted by fluorine atoms; or an alkylene group wherein an oxygen atom is present at an end of the group to be bonded to a cyclic group.Type: ApplicationFiled: November 23, 2010Publication date: March 17, 2011Applicant: ASAHI GLASS COMPANY, LIMITEDInventors: Nobuhiko TAKESHITA, Teppei Konishi, Hiroshi Kumai
-
Publication number: 20110054193Abstract: The present invention relates to a polypeptide with HMG-CoA reductase activity, to its polynucleotide congener and to a method for the production of a statin comprising over expression of said polypeptide.Type: ApplicationFiled: April 28, 2009Publication date: March 3, 2011Inventors: Marco Alexander Van Den Berg, Marcus Hans
-
Publication number: 20110028712Abstract: The present invention relates to a salt of a carboxylic acid with a diamine such as 2,2?-(ethylenedioxy)diethyl amine, 3,3?-(ethylenedioxy)dipropyl amine and 2,2?-oxybis(ethylamine) and a method of preparing such salts. Preferably the carboxylic acid is a fermentation product such as clavulanic acid, mycophenolic acid or pravastatin.Type: ApplicationFiled: March 31, 2009Publication date: February 3, 2011Inventors: Robertus Mattheus De Pater, Adrianus Antonius Wijk Van, Piotr Wnukowski
-
Publication number: 20100320419Abstract: A polymerizable compound represented by general formula (1): wherein A represents a ring assembly composed of at least two 6-membered rings each optionally having a substituent; X1 and X2 each represent a (meth)acryloyloxy group; and Y1 and Y2 each independently represent a single bond, an optionally branched alkylene group having 1 to 8 carbon atoms, an ether linkage, —COO—, —OCO—, a 6-membered ring optionally having a substituent, a naphthalene ring optionally having a substituent, or a combination thereof; the substituent being a hydrogen atom, a halogen atom, a nitrile group, an optionally branched alkyl group having 1 to 8 carbon atoms, an optionally branched alkoxy group having 1 to 8 carbon atoms, or an optionally branched alkenyl group having 2 to 8 carbon atoms, wherein the alkyl, alkoxy, or alkenyl group may have its —CH2— moiety replaced with a sulfur atom or an oxygen atom and may have its hydrogen atom replaced with a halogen atom or a nitrite group.Type: ApplicationFiled: October 9, 2007Publication date: December 23, 2010Applicant: ADEKA CORPORATIONInventors: Masatomi Irisawa, Mineki Hasegawa
-
Publication number: 20100305165Abstract: Disclosed herein are thiocolchicine derivatives suitable for use as muscle relaxants, methods of making the derivatives, and compositions comprising the derivatives.Type: ApplicationFiled: May 27, 2010Publication date: December 2, 2010Inventor: Rajesh Manchanda
-
Publication number: 20100274043Abstract: The present invention provides an adamantyl group containing epoxy-modified (meth)acrylate and a resin composition containing it which are imparted by transparency, optical characteristics such as (durable) light resistance and the like, heat-resistance, and good mechanical properties. For example, they are an adamantyl group containing epoxy-modified (meth)acrylate having the following general formula (I) and a composition containing it. In the formula, R1 represents a hydrogen atom or a methyl group, and R2 represents a halogen atom or an aliphatic hydrocarbon group which may contain a hetero atom. Plural R2 may be the same or different, and m represents an integer of 0 to 4 and n represents an integer of 0 or more.Type: ApplicationFiled: July 7, 2010Publication date: October 28, 2010Applicant: Idemitsu Kosan Co., Ltd.Inventors: Yasunari OKADA, Hajime ITO, Hideki YAMANE, Nobuaki MATSUMOTO
-
Publication number: 20100273801Abstract: The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.Type: ApplicationFiled: June 6, 2007Publication date: October 28, 2010Applicant: Valition teknillinen tutikimuskeskusInventors: Jari Yli-Kauhaluoma, Salme Koskimies, Sami Alakurtti, Taru Mäkelä, Päivi Tammela
-
Publication number: 20100240905Abstract: The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.Type: ApplicationFiled: October 12, 2007Publication date: September 23, 2010Applicant: RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORKInventors: Krishnaswami Raja, Probal Banerjee, Andrew Auerbach, Wei Shi, William L'Amoreaux
-
Patent number: 7790917Abstract: The present invention provides an adamantyl group containing epoxy-modified (meth)acrylate and a resin composition containing it which are imparted by transparency, optical characteristics such as (durable) light resistance and the like, heat-resistance, and good mechanical properties. For example, they are an adamantyl group containing epoxy-modified (meth)acrylate having the following general formula (I) and a composition containing it. In the formula, R1 represents a hydrogen atom or a methyl group, and R2 represents a halogen atom or an aliphatic hydrocarbon group which may contain a hetero atom. Plural R2 may be the same or different, and m represents an integer of 0 to 4 and n represents an integer of 0 or more.Type: GrantFiled: April 24, 2007Date of Patent: September 7, 2010Assignee: Idemitsu Kosan Co., Ltd.Inventors: Yasunari Okada, Hajime Ito, Hideki Yamane, Nobuaki Matsumoto
-
Publication number: 20100222534Abstract: The invention relates to novel mesogenic dimeric compounds which are especially suitable for use in birefringent films with negative optical dispersion, to novel liquid crystal (LC) formulations and polymer films comprising them, and to the use of the dimers, formulations and films in optical, electrooptical, electronic, semiconducting or luminescent components or devices.Type: ApplicationFiled: August 29, 2008Publication date: September 2, 2010Applicant: Merck Patent GesellschaftInventors: Kevin Adlem, Owain Llyr Parri, Karl Skjonnemand, David Wilkes
-
Publication number: 20100217032Abstract: The present invention provides a polypeptide having an amino acid sequence according to SEQ ID NO 3, SEQ ID NO 6 or SEQ ID NO 43-59. The present invention also provides a polynucleotide comprising a DNA sequence encoding these polypeptides and a method for isolating polynucleotides encoding polypeptides capable of improving the compactin into pravastatin conversion. Furthermore, the present invention provides a method for producing pravastatin and a pharmaceutical composition comprising pravastatin.Type: ApplicationFiled: December 11, 2007Publication date: August 26, 2010Inventors: Paul Klaassen, Adrianus Wilhelmus Hermanus Vollebregt, Marco Alexander Van Den Berg, Marcus Hans, Jan Metske Van Der Laan
-
Publication number: 20100190795Abstract: The invention relates to betulin derivatives, and to the use thereof as agents against protozoa of the genus Leishmania and against leishmaniasis in applications of pharmaceutical industry.Type: ApplicationFiled: June 6, 2007Publication date: July 29, 2010Applicant: Valtion Teknillinen tutkimuskeskusInventors: Jari Yli-Kauhaluoma, Sami Alakurtti, Jaana Minkkinen, Nina Sarcerdoti-Sierra, Charles L. Jaffe, Tuomo Heiska
-
Publication number: 20100174075Abstract: The present invention relates to the use of nitric oxide-releasing statins of formula (I) for the treatment of pulmonary arterial hypertension.Type: ApplicationFiled: May 12, 2008Publication date: July 8, 2010Applicant: NICOX S.A.Inventors: John Wharton, Angela Monopoli
-
Publication number: 20100145068Abstract: The present invention relates to a dendritic photoactive compound that comprises oxime ester and a method for producing the same. Since the compound according to the present invention comprises two or more oxime ester groups and chromophores in one molecule at the same time, the solubility in respects to the organic solvent and the efficiency for producing a radical by absorbing ultraviolet rays are excellent.Type: ApplicationFiled: July 15, 2008Publication date: June 10, 2010Inventors: Keon-Woo Lee, Chang-Ho Cho, Kyoung-Hoon Min, Raisa Kharbash, Chang-Soon Lee, Sung-Hyun Kim
-
Publication number: 20100130438Abstract: A method for increasing oxytocin release through direct action on the epidermal keratinocytes is provided. The method for increasing oxytocin release in the epidermis includes increasing the calcium ion concentration in the epidermal cells. In the method of the present invention, the increase of the calcium ion concentration in the epidermal cells may be achieved by physically stimulating the skin. The physical stimulation may be achieved by applying a heat stimulus and/or a massage. The increase of the calcium ion concentration in the epidermal cells may be achieved by stimulating the epidermal cells by at least one agent selected from the group consisting of ATP, UTP, 4 alpha-phorbol 12,13-didecanoate, and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: November 12, 2009Publication date: May 27, 2010Applicant: SHISEIDO COMPANY, LTD.Inventors: Sumiko Denda, Mitsuhiro Denda, Kazuyuki Ikeyama
-
Publication number: 20100103366Abstract: The invention relates to new cyclohexylene reactive mesogens (RM), polymers derived thereof, liquid crystal (LC) media comprising them, and the use of the compounds, polymers and liquid crystalline media in optical, electrooptical, electronic, semiconducting or luminescent components or devices, in decorative, security, cosmetic or diagnostic applications, especially in the polymer stabilised blue phase.Type: ApplicationFiled: October 26, 2007Publication date: April 29, 2010Applicant: MERCK PATENT GMBHInventors: Louise Diane Farrand, Kevin Adlem, Andreas Taugerbeck, John Patrick, Christopher John Dunn, Janice Mccreary
-
Publication number: 20100087563Abstract: Compounds of the formula (I), wherein L1, L2, L3 and L4 independently of one another are hydrogen or an organic substituent; R is for example C1-C20alkyl, C5-C12cycloalkyl, C2-C20alkenyl, substituted C1-C20alkyl; X is O, S, NRa or NCORa; Ra is for example hydrogen or C1-C20alkyl; and Y is an inorganic or organic anion; are suitable as photolatent acid generators.Type: ApplicationFiled: September 24, 2007Publication date: April 8, 2010Inventors: Pascal Hayoz, Jean-Luc Birbaum, Stephan Ilg
-
Publication number: 20100004333Abstract: The present invention relates to compounds and methods for the treatment of cardiovascular diseases and disorders. Compounds according to the present invention may comprise an optionally substituted phenyl ring linked to an aromatic or alkyl group by a spacer, wherein the spacer comprises two groups selected from selenium, sulfur, S(O) and S(O)2 and may further optionally comprise an alkylene, alkenylene, cycloalkylene or arylene moiety between the respective selenium, sulfur, S(O) and S(O)2 groups.Type: ApplicationFiled: December 16, 2005Publication date: January 7, 2010Inventor: Roland O. Stocker
-
Publication number: 20090286837Abstract: The present invention relates to novel compounds which inhibit urokinase-plasminogen activator (uPA), have a high bioavailability and can be administered orally, and to their use as therapeutic active substances for the treatment of disorders associated with urokinase and/or urokinase receptor, for example tumours and metastasis. The invention relates in particular to compounds containing oxadiazole groups.Type: ApplicationFiled: August 29, 2006Publication date: November 19, 2009Inventors: Stefan Sperl, Jana Zimmermann, Klaus Koch
-
Publication number: 20090239955Abstract: Disclosed herein are novel obovatol derivatives represented by Chemical Formula 1, and pharmaceutically acceptable salts thereof. Having the ability to inhibit the growth of cancer cells and induce apoptosis in cancer cells, the derivatives or pharmaceutically acceptable salts thereof are useful in the prevention and treatment of cancer and in the suppression of cancer metastasis. Also, a method for preparing the derivatives, and pharmaceutical compositions comprising the derivatives as active ingredients are disclosed. wherein R1,R2 and R3 are as defined in the specification.Type: ApplicationFiled: July 28, 2008Publication date: September 24, 2009Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Byoung-Mog Kwon, Dong Cho Han, Su-Kyung Lee, Hye-Nan Kim, Young-Min Han, Dae-Seop Shin
-
Publication number: 20090184417Abstract: Disclosed are photosensitizers that include a polyol moiety covalently bonded to a fused aromatic moiety. Also disclosed is a method for improving UV laser ablation performance of a coating, such as a cationic UV curable coating, by incorporating an oxalyl-containing additive into the cationic UV curable or other coating. Oxalyl-containing sensitizers having the formula Q-O—C(O)—C(O)—O—R1, wherein Q represents a fused aromatic moiety and R1 is an alkyl or aryl group, are also disclosed, as are oxalyl-containing oxetane resins, oxalyl-containing polyester polyols, and cationic UV curable coating formulations that include oxalyl-containing additives.Type: ApplicationFiled: April 21, 2007Publication date: July 23, 2009Inventors: Dean C. Webster, Zhigang Chen
-
Publication number: 20090163476Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.Type: ApplicationFiled: March 3, 2006Publication date: June 25, 2009Applicant: Sirtris Pharmaceuticals, Inc.Inventors: Michael Milburn, Jill Milne, Jean Bemis, Joseph J. Nunes, Roger Xie, Karl D. Normington, Chi B. Vu
-
Publication number: 20090155714Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula. Also, the present invention provides a photoresist composition comprising 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 10 to 5000 weight parts of an organic solvent. In the formula, n is 0 or 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, z is 0, 1, 2, 3 or 4, R, R? and R? are independently hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms, and R?? is a hydrogen atom or hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms.Type: ApplicationFiled: December 17, 2008Publication date: June 18, 2009Inventors: Jae-Woo LEE, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
-
Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
Publication number: 20090093652Abstract: The present invention provides crystalline forms of Cinacalcet Fumarate and Cinacalcet Succinate, pharmaceutical compositions comprising the crystalline form of Cinacalcet Fumarate and/or the crystalline form of Cinacalcet Succinate, and processes for preparing the crystalline forms of Cinacalcet Fumarate and Cinacalcet Succinate and pharmaceutical compositions comprising the crystalline forms.Type: ApplicationFiled: August 18, 2008Publication date: April 9, 2009Inventors: Michal Rafilovich, Amihai Eisenstadt -
Publication number: 20090082311Abstract: The present invention provides a novel compound having few side effects such as bradycardia and the like and having superior peripheral blood lymphocyte-decreasing effect.Type: ApplicationFiled: April 27, 2007Publication date: March 26, 2009Applicant: Mitsubishi Tanabe Pharma CorporationInventors: Masatoshi Kiuchi, Mitsuharu Nakamura, Maiko Hamada, Kunio Sugahara
-
Publication number: 20080300304Abstract: The present invention relates to a process for preparing a ginger fraction, the fraction prepared by this process and the use thereof on its own or combined with drugs for inhibiting human cytochrome P450 (CYP) enzymes (particularly cytochrome P450 3A4, CYP3A4) for positively influencing the oral bioavailability and pharmacokinetics of active substances.Type: ApplicationFiled: December 20, 2006Publication date: December 4, 2008Inventors: Thomas Ebner, Eva Christine Ludwig-Schwellinger, Stefan Blech, Rolf-Stefan Brickl
-
Patent number: 7282521Abstract: The present invention provides moronic acid derivatives of the general formula: which have antiviral activity, along with compositions containing the same and methods of use thereof.Type: GrantFiled: May 23, 2005Date of Patent: October 16, 2007Assignees: University of North Carolina at Chapel Hill, Duke UniversityInventors: Kuo-Hsiung Lee, Fang-Rong Chang, Yojiro Sakurai, Chin Ho Chen
-
Patent number: 7273948Abstract: A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.Type: GrantFiled: January 13, 2004Date of Patent: September 25, 2007Assignee: AtheroGenics, Inc.Inventors: M. David Weingarten, James A. Sikorski
-
Patent number: 7230030Abstract: The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.Type: GrantFiled: January 27, 2004Date of Patent: June 12, 2007Assignee: Schwarz Pharma AGInventors: Claus Meese, Bengt Sparf
-
Patent number: 7045524Abstract: Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy.Type: GrantFiled: November 12, 2001Date of Patent: May 16, 2006Assignee: SmithKline Beecham p.l.c.Inventors: David Kenneth Dean, Antoinette Naylor, Andrew Kenneth Takle
-
Publication number: 20040210081Abstract: The present invention relates to carboxylic esters based on 2-hydroxymethylnorbornane and on aliphatic dicarboxylic acids of the formula 1Type: ApplicationFiled: March 19, 2004Publication date: October 21, 2004Inventors: Peter Lappe, Helmut Springer
-
Publication number: 20030120086Abstract: Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor or Penicillium genus, some are obtained by treating the fermentation products using the methods of chemical synthesis or they are the products of total chemical synthesis.Type: ApplicationFiled: December 16, 2002Publication date: June 26, 2003Applicant: Lek Pharmaceuticals d.d.Inventor: Zlatko Pflaum
-
Publication number: 20030114685Abstract: Processes for preparing a calcium salt of a statin from an ester derivative or protected ester derivative of the statin by using calcium hydroxide are provided. The ester or protected ester derivative is contacted with calcium hydroxide to obtain the calcium salt. Preferred statins are rosuvastatin, pitavastatin and atorvastatin, simvastatin and lovastatin. In processes beginning with a protected statin ester derivative, the protecting group is hydrolyzed during salt formation by contact with calcium hydroxide, or is contacted with an acid catalyst followed by contact with calcium hydroxide.Type: ApplicationFiled: August 16, 2002Publication date: June 19, 2003Inventors: Valerie Niddam-Hildesheim, Revital Lifshitz-Liron, Rami Lidor-Hadas
-
Patent number: 6476251Abstract: The present invention relates to a novel process for preparing compounds of the formula (I) by reacting compounds of the formula (II) with a base and compounds of the formula (III) in which X, Y, Z, n, G, A, B, R1, R8 and Hal are each as defined above.Type: GrantFiled: March 12, 2001Date of Patent: November 5, 2002Assignees: Bayer Aktiengesellschaft, Bayer CorporationInventor: Volker Falbe
-
Patent number: 6451380Abstract: Compounds useful as reactive coalescents and methods of improving the stability of reactive coalescents are disclosed. A process for the preparation of low molecular weight polymers which are also useful as reactive coalescents is also disclosed.Type: GrantFiled: March 25, 1998Date of Patent: September 17, 2002Inventors: David Gerald Speece, Jr., William David Weir, Eric Karl Eisenhart, Michael Damian Bowe, Martha Alice Harbaugh Wolfersberger
-
Patent number: 6369109Abstract: The present invention is, generally, directed to the use of betulinic acid and derivatives thereof for the treatment of neuroectodermal tumors. The present invention is based on the discovery that betulinic acid and its derivatives are potent anti-neuroectodermal agents. As disclosed herein, betulinic acid and its derivatives are useful for the treatment of neuroectodermal tumors, including, due to its distinct mechanism of action, neuroectodermal tumors that are resistant to conventional chemotherapeutical agents. In addition to the new use of known compounds, the invention discloses novel compounds and pharmaceutical compositions for the treatment of neuroectodermal tumors.Type: GrantFiled: October 28, 1998Date of Patent: April 9, 2002Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Klaus Michael Debatin, Simone Fulda, Manfred Wiessler, Marek Los, Walter Mier
-
Patent number: 6331641Abstract: This invention provides an easy and efficient process for producing a simvastatin of great use as an HMG-CoA reductase inhibitor, which comprises deacylation of lovastatin with an inorganic base and a secondary or tertiary alcohol and subjecting the resulting diol lactone to selective protection with a ketal or acetal protective group, acylation and deprotection-lactonization to give simvastatin.Type: GrantFiled: September 28, 2000Date of Patent: December 18, 2001Assignee: Kaneka CorporationInventors: Naoaki Taoka, Kenji Inoue
-
Patent number: 6315987Abstract: A polymer useful in oral care compositions which has a reactive group covalently bonded to a bactericide, flavorant and/or essential oil compound, said bond being hydrolyzable in aqueous solution to slowly release said compound into said composition.Type: GrantFiled: May 10, 2000Date of Patent: November 13, 2001Assignee: ISP Investments Inc.Inventor: Krystyna Plochocka
-
Patent number: 6303589Abstract: The present invention relates to fungicidally effective compositions containing at least one pentacyclic triterpene compound.Type: GrantFiled: December 8, 1998Date of Patent: October 16, 2001Assignee: Micro Flo CompanyInventors: Jan Glinski, Keith L. Branly
-
Publication number: 20010018540Abstract: A process for preparing malonic diesters by carbonylation of haloacetic esters and reaction with monohydric alcohols and a base in the presence of a transition metal catalyst, preferably a catalytic cobalt carbonyl complex, using a stirred reactor with one or more internal heat exchangers. The stirred reactor preferably contains a sparging stirrer.Type: ApplicationFiled: December 1, 2000Publication date: August 30, 2001Inventors: Frank Bauer, Wilfried Latz, Uwe Prange, Christoph Theis
-
Patent number: 6255523Abstract: The present invention relates to powder coating compositions which can be cured at low temperatures. The powder coating composition of the invention include a unique combination of a branched oligoester polyol and uretdione crosslinking agent which when cured results in a coating binder with desirable hardness, flexibility, solvent resistance, corrosion resistance, weatherability and gloss.Type: GrantFiled: September 18, 1998Date of Patent: July 3, 2001Assignee: McWhorter Technologies, Inc.Inventors: Kamlesh Pai Panandiker, John Michael Bronk, Franklin Paul Spitler
-
2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
Patent number: 6214873Abstract: The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.Type: GrantFiled: January 5, 2000Date of Patent: April 10, 2001Assignee: Welfide CorporationInventors: Kunitomo Adachi, Yoshiyuki Aoki, Tokushi Hanano, Koji Teshima, Yukio Hoshino, Tetsuro Fujita -
Patent number: 6172110Abstract: Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have the following formulae: or pharmaceutically acceptable salts thereof, wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl, R2 is a C2-C20 substituted or unsubstituted carboxyacyl; and R3 is hydrogen, halogen, amino, optionally substituted mono- or di-alkylamino, or —OR4, where R4 is hydrogen, C1-4 alkanoyl, benzoyl, or C2-C20 substituted or unsubstituted carboxyacyl; wherein the dashed line represents an optional double bond between C20 and C29.Type: GrantFiled: March 2, 1999Date of Patent: January 9, 2001Assignees: The University of North Carolina at Chapel Hill, BBI Biotech Research Laboratories, Inc.Inventors: Kuo-Hsiung Lee, I-Chen Sun, Hui-Kang Wang, Louis Mark Cosentino
-
Patent number: 6166244Abstract: Compounds of the Formula 1, Formula 2, Formula 3 and Formula 4 wherein the symbols have the meaning assigned to them in the disclosure have retinoid-like biological activity.Type: GrantFiled: May 7, 1999Date of Patent: December 26, 2000Assignee: Allergan Sales, Inc.Inventors: Richard L. Beard, Diana F. Colon, Roshantha A. Chandraratna
-
2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
Patent number: RE39072Abstract: The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.Type: GrantFiled: April 3, 1998Date of Patent: April 18, 2006Assignee: Mitsubishi Pharma CorporationInventors: Kunitomo Adachi, Yoshiyuki Aoki, Tokushi Hanano, Koji Teshima, Yukio Hoshino, Tetsuro Fujita