Plural Rings In Alcohol Moiety Patents (Class 560/194)
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Patent number: 6080739Abstract: The present invention relates to colchicine and thiocolchicine derivatives which can be obtained from these molecules by functionalization of the C-7 to ketone or functionalization of the amino group. Said compounds have a marked antiblastic activity both on the normal cancer cells and on the chemoresistant phenotype. The compounds of the invention can be administered both by injection and orally.Type: GrantFiled: November 24, 1998Date of Patent: June 27, 2000Assignee: Indena S.p.A.Inventor: Ezio Bombardelli
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Patent number: 6057460Abstract: Polymerizable hybrid monomers with norbornenyl or norbornadienyl groups are described which can be radically cured at room temperature and are suitable in particular for use in the dental field.Type: GrantFiled: February 21, 1997Date of Patent: May 2, 2000Assignee: Ivoclar AGInventors: Norbert Moszner, Volker Rheinberger, Frank Zeuner
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Patent number: 6022890Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 21, 1998Date of Patent: February 8, 2000Assignee: Merck & Co., Inc.Inventors: Jianming Bao, Robert K. Baker, Frank Kayser, Andrew Kotliar, William H. Parsons, Kathleen M. Rupprecht, Peter J. Sinclair
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Patent number: 6002039Abstract: Acetylenic maleates, fumarates and related derivative compounds are new compositions of matter having the formula:R.sub.1 O.sub.2 C--CH.dbd.CH--CO.sub.2 R.sub.2wherein R.sub.1 may be an organic moiety containing at least two carbon atoms triply bonded one to the other as:--C.tbd.C--and R.sub.2 may be hydrogen, an organic moiety, or R.sub.1 ; suitable for use as liquid injection molding inhibitors either singly or in combination with themselves or other liquid injection molding inhibitors when used for the process of liquid injection molding curable compositions enabling an increase in the size of articles manufactured therefrom, which new compositions of matter cure into the polymerizable or curable resins thereby creating new compositions of matter as cured resins from which said articles of manufacture are produced.Type: GrantFiled: January 18, 1996Date of Patent: December 14, 1999Assignee: General Electric CompanyInventors: Philip J. McDermott, Michael J. O'Brien, Edward M. Jeram
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Patent number: 5998471Abstract: Compounds of the formula ##STR1## the symbols have the meaning described in the specification.Type: GrantFiled: August 11, 1998Date of Patent: December 7, 1999Assignee: Allergan Sales, Inc.Inventors: Alan T. Johnson, Min Teng, Vidyasagar Vuligonda, Richard L. Beard, Samuel J. Gillett, Tien T. Duong, Roshantha A. Chandraratna
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Patent number: 5955501Abstract: Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.Type: GrantFiled: June 7, 1995Date of Patent: September 21, 1999Assignee: Procyon Pharmaceuticals, Inc.Inventors: Paul E. Driedger, James Quick
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Patent number: 5939580Abstract: Process for preparing glyoxylic esters or their hydrates in which a water-soluble salt of a maleic or fumaric monoester or a mixture thereof is reacted with ozone in aqueous solution at temperatures of from 0 to 50.degree. C., and the corresponding glyoxylic ester or its hydrate is isolated from the resulting reaction mixture.Type: GrantFiled: November 21, 1997Date of Patent: August 17, 1999Assignee: DSM Fine Chemicals Austria GmbHInventors: Engelbert Kloimstein, Wolfram Hendel, Klaus Reiter, Christian Burger, Antonia Praus, Karl Heinz Giselbrecht, Eduard Perndorfer
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Patent number: 5817256Abstract: The invention is directed to an immersion oil for microscopy. The immersion oil includes an ester or ether with tricyclodecane structure as a main constituent and one or more high-boiling liquids as minor constituents. The immersion oil is free of halogens and exhibits a high UV-transmissibility and is characterized by low intrinsic fluorescence because the components utilized can be vacuum distilled.Type: GrantFiled: March 3, 1997Date of Patent: October 6, 1998Assignee: Carl-Zeiss-StiftungInventor: Hans-Joachim Weippert
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Patent number: 5750750Abstract: A complex alcohol ester which comprises the reaction product of an add mixture of the following: a polyhydroxyl compound represented by the general formula:R(OH).sub.nwherein R is any aliphatic or cyclo-aliphatic hydrocarbyl group and n is at least 2, provided that the hydrocarbyl group contains from about 2 to 20 carbon atoms; a polybasic acid or an anhydride of a polybasic acid, provided that the ratio of equivalents of the polybasic acid to equivalents of alcohol from the polyhydroxyl compound is in the range between about 1.6:1 to 2:1; and a monohydric alcohol, provided that the ratio of equivalents of the monohydric alcohol to equivalents of the polybasic acid is in the range between about 0.84:1 to 1.2:1; wherein the complex alcohol ester exhibits a pour point of less than or equal to -20.degree. C., a viscosity in the range between about 100-700 cSt at 40.degree. C. and having a polybasic acid ester concentration of less than or equal to 70 wt. %, based on the complex alcohol ester.Type: GrantFiled: February 7, 1997Date of Patent: May 12, 1998Assignee: Exxon Chemical Patents Inc.Inventors: Carolyn Boggus Duncan, Paul R. Geissler, David Wayne Turner, William Joseph Munley, Jr., Martin A. Krevalis
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Patent number: 5726344Abstract: There is disclosed a two-stage enzymatically catalyzed reaction for the selective preparation of the (R)-endo-isomer of norbornenol from a mixture containing all four stereo- and regioisomers of norbornenol, as well as the synthesis of the intermediate product comprising the enantiomerically enriched mono-ester of (R)-endo-norbornenol and a diacid, and of the enantiomerically enriched saturated alcohol (R)-endo-norborneol. There is also disclosed a method for the production of (R)-endo-norborne-2-ol, by chemical reduction of either the enantiomerically enriched monoester and subsequent hydrolysis, or by hydrolysis of the enantiomerically enriched monoester and then chemical reduction.Type: GrantFiled: August 15, 1995Date of Patent: March 10, 1998Assignee: Bend Research, Inc.Inventors: J. Blair West, Keith DeVries
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Patent number: 5679828Abstract: Some betulinic acid and dihydrobetulinic acid acyl derivatives according to the present invention have been found to have potent anti-HIV activity. Introducing a C.sub.2 -C.sub.20 substituted or unsubstituted acyl group at the C.sub.3 -hydroxy group of betulinic acid and dihydrobetulinic acid produces the corresponding 3-O-acyl derivatives. The compounds of the present invention have the following formulae: ##STR1## where R may be a mono- or dicarboxylacyl group, substituted or unsubstituted, of from about 2 to about 20 carbon atoms, and R' may be hydrogen or a C.sub.2 -C.sub.10 substituted and unsubstituted alkyl or aryl group.Type: GrantFiled: June 5, 1995Date of Patent: October 21, 1997Assignees: Biotech Research Labs, Inc., University of North Carolina at Chapel HillInventors: Kuo-Hsiung Lee, Yoshiki Kashiwada, Fumio Hashimoto, Louis Mark Cosentino, Mark Manak
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Patent number: 5643948Abstract: Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes of the phorbol-, resiniferonol- and ingenol-classes.Type: GrantFiled: September 13, 1993Date of Patent: July 1, 1997Assignee: Procyon Pharmaceuticals, Inc.Inventors: Paul E. Driedger, James Quick
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Patent number: 5563290Abstract: A method for preparing an optically active succinic acid compound involves hydrogenating an itaconic acid compound in the presence of a rhodium compound and a 2,2"-bis(1-(hydrocarbon residue-substituted) phosphine-substituted alkyl)-1,1"-biferrocene compound.Type: GrantFiled: December 30, 1994Date of Patent: October 8, 1996Assignee: Nippon Oil Co. Ltd.Inventor: Yoshihiko Ito
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Patent number: 5560850Abstract: New oligoesters made from a tricyclic diol with 8 to 20 carbon atoms, a dicarboxylic acid with 4 to 20 carbon atoms, and an aliphatic alcohol with 1 to 30 carbon atoms are useful as lubricants, hydraulic oils and compressor oils for mobile field use in forestry and agriculture, in construction, in mining and in transport. The oligoesters have a kinematic viscosity of 50 to 50,000 mm.sup.2 /s at 40.degree. C. and are biodegradable.Type: GrantFiled: October 13, 1995Date of Patent: October 1, 1996Assignee: Roehm GmbH Chemische FabrikInventors: Dirk Hoppe, Clemens Auschra
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Patent number: 5372814Abstract: A sterol derivative represented by the general formulas (I) or (II) which is widely usable as the external base for the skin, emulsifier, etc., for cosmetics, toiletries, medicines, etc., since they have an excellent effect of remedying the chaps of the skin, are capable of stabilizing the lamellar liquid crystal structure and have an excellent surface-activating effect: ##STR1## wherein: R.sup.1 represents a residue remaining after removing the hydrogen atom from the hydroxyl group of a sterol having one hydroxyl group,R.sup.2 represents a group of the formula: ##STR2## (in which R.sup.3 represents an alkenyl or alkyl group having 6 to 20 carbon atoms),M represents a hydrogen atom, alkali metal, etc.,and L represents an alkaline earth metal.Type: GrantFiled: February 3, 1993Date of Patent: December 13, 1994Assignee: Kao CorporationInventors: Hiromoto Mizushima, Junichi Fukasawa
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Patent number: 5248727Abstract: Thermoplastic molding compositions of a vinyl chloride polymer and one or more emulsion polymers made with special emulsifiers have improved properties for technical application, such as reduced fogging. They are used for the production of molded articles, sheet products and films.Type: GrantFiled: May 18, 1992Date of Patent: September 28, 1993Assignee: Bayer AktiengesellschaftInventors: Christian Lindner, Adolf Schmidt, Herbert Eichenauer, Karl-Erwin Piejko, Karl-Heinz Ott
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Patent number: 5245050Abstract: A compound represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different, and represent a hydrogen or halogen, and ring-opened free acid, amides and salts thereof are provided. The present invention also provides a process for the production of the above-mentioned compound starting from the known compound ML-236B.Type: GrantFiled: October 3, 1989Date of Patent: September 14, 1993Assignee: Tobishi Yakuhin Kogyo Kabushiki KaishaInventors: Akira Endo, Tadashi Toshioka, Isao Umezawa, Masayuki Yuasa, Takashi Inaba, Tsutomu Inoue
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Patent number: 5241105Abstract: In one embodiment this invention provides smoking compositions which contain a novel oxalate ester flavorantrelease additive.Under cigarette smoking conditions, a combustible filler additive such as methyl 4-oxo-.beta.-ionyl oxalate pyrolyzes and releases megastigma-5,7,9-trien-4-one as a natural flavorant component of the cigarette smoke.Type: GrantFiled: September 10, 1992Date of Patent: August 31, 1993Assignees: Philip Morris Incorporated, Philip Morris Products Inc.Inventor: W. Geoffrey Chan
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Patent number: 5239086Abstract: Disclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX).Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten.Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene.Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen.Type: GrantFiled: July 29, 1991Date of Patent: August 24, 1993Assignee: Abbott LaboratoriesInventors: Robert E. Dubler, Jonathan Grote, Donna R. Kuhn
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Patent number: 5237110Abstract: This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.Type: GrantFiled: February 16, 1990Date of Patent: August 17, 1993Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Rafal R. Sicinski, Jean M. Prahl
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Patent number: 5232836Abstract: Vitamin D derivatives corresponding to the following formula I ##STR1## in which R.sub.1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D.sub.2 (C.sup.20 to C.sup.28) or D.sub.3 (C.sup.20 to C.sup.Type: GrantFiled: February 18, 1992Date of Patent: August 3, 1993Assignee: Ire-Medgenix S.A.Inventors: Roger Bouillon, Pierre J. De Clerco, Pierre Eliard, Maurits Vanderwalle
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Patent number: 5214195Abstract: The present invention provides new allyl esters of the general formula:X--CH.sub.2 --CR.sup.1 .dbd.CR.sup.2 --CO--Y--R.sup.3 --A (I)wherein R.sup.1 and R.sup.2, which can be the same or different, are hydrn or halogen atoms or alkyl or aryl radicals, R.sup.3 is a linking grouping (spacer), X is an acyloxy radical in which acyl in the acyloxy radical is the residue of an aliphatic carboxylic acid or is the radical RCO-- in which R is an organic radical, Y is an oxygen or sulphur atom or especially an --NH-- group and A is a grouping which can react with a solid carrier material F, which contains appropriate functional groups B, either after selective deblocking or directly, whereby A and B are atom groupings which react with one another with condensation and/or addition and formation of a linkage between the solid carrier material and the radical X--CH.sub.2 --CR.sup.1 .dbd.CR.sup.2 --CO--Y--R.sup.3 --.The present invention also provides processes for the preparation of these new allyl esters.Type: GrantFiled: August 31, 1990Date of Patent: May 25, 1993Assignee: Orpegen Medizinisch-Molekular Biologische Forschungsgesellschaft mbHInventors: Horst Kung, Winfried Kosch, Joachim Marz
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Patent number: 5126474Abstract: Polyadducts of an alkylene oxide and styrene oxide with an aryl alcohol, especially polyadducts of formulae ##STR1## wherein the ring A is an unsubstituted phenyl radical or a phenyl radical which is substituted by halogen, methyl or C.sub.1 -C.sub.3 alkoxy,Q.sub.1 is alkylene of 1 to 4 carbon atoms, preferably methylene, in the pairs of substituents (Y.sub.1 and Y.sub.2) and (Y.sub.3 and Y.sub.4) one Y is phenyl and the other Y is hydrogen,"alkylene" denotes an alkylene radical of 2 or 3 carbon atoms, andm is an integer from 1 to 80.These polyadducts are a novel class of nonionic or anionic surfactants which are used as textile auxiliaries.Type: GrantFiled: September 20, 1990Date of Patent: June 30, 1992Assignee: Ciba-Geigy CorporationInventor: Rosemarie Topfl
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Patent number: 5114616Abstract: The novel glycidyl ether addition products are obtained by esterification of a diol compound, selected from the group comprising linear oxyalkylates and other amine-free aliphatic diols, and an addition compound of polyether block polymers and glycidyl ethers with dicarboxylic acids. They are advantageously employed for demulsifying crude oil emulsions.Type: GrantFiled: August 20, 1990Date of Patent: May 19, 1992Assignee: Hoechst AktiengesellschaftInventors: Rainer Kupfer, Martin Hille, Roland Bohm, Friedrich Staiss
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Patent number: 5093519Abstract: Vitamin D derivatives corresponding to the following formula I ##STR1## in which R.sub.1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D.sub.2 (C.sup.20 to C.sup.28) or D.sub.3 (C.sup.20 to C.sup.Type: GrantFiled: May 1, 1989Date of Patent: March 3, 1992Assignee: Ire-Medgenix S.A.Inventors: Roger Bouillon, Pierre J. De Clercq, Pierre Eliard, Maurits Vandewalle
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Patent number: 5025017Abstract: Seco-mevinic acid derivatives are provided which has the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R.sup.1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroaryl, aralkyl, heteroaralkyl or heterocyclic; R.sup.2 is lower alkyl, cycloalkyl or aralkyl, and X is O or NR.sup.5 wherein R.sup.5 is H or lower alkyl, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis. New intermediates for preparing the above seco-mevinic acid derivatives are also provided.Type: GrantFiled: September 28, 1989Date of Patent: June 18, 1991Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 5001120Abstract: A-Nor-5.alpha.-androstane compounds, such as the dipropionate and disuccinate esters of 2.alpha.,17.alpha.-diethynyl-A-Nor-5.alpha.-androstane-2.beta.,17.beta.-di ol and the corresponding 2.alpha.,17.alpha.-diol stereoisomers have an inhibitory effect on malignant cell growth and can be used to treat various carcinomas in mammals.Type: GrantFiled: May 10, 1989Date of Patent: March 19, 1991Assignee: Natural Pharmacia International, Inc.Inventors: Rui-Lin Li, David Y. Lee, Qi-Lu Cheng
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Patent number: 4958046Abstract: Hydroxypropafenone glycerides of the formula I ##STR1## where R is n-propyl or 1,1-dimethylpropyl,x is 2 or 3,y is 12, 14, 16, 18 or 20, anda and b differ from one another and are 0 or 1,as well as the stereoisomers thereof and the preparation thereof are described. The compounds are suitable as active substances for antiarrhythmics.Type: GrantFiled: September 19, 1989Date of Patent: September 18, 1990Assignee: Knoll AGInventors: Joerg Rosenberg, Juergen Heberger, Hans-Heinrich Gruenhagen, Egon Brode, Gerda von Philipsborn
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Patent number: 4940696Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.Type: GrantFiled: November 16, 1987Date of Patent: July 10, 1990Assignee: Centre International de Recherches Dermatologioues (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Patent number: 4933475Abstract: Compounds having the formula ##STR1## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.Type: GrantFiled: February 28, 1989Date of Patent: June 12, 1990Assignee: Pfizer, Inc.Inventors: Michael R. Johnson, Lawrence S. Melvin, Jr.
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Patent number: 4883887Abstract: A process for producing carotenoids and carotenoid intermediates via reduction of sulfonyl polyenes with a dithionite in the presence of ammonia or an aliphatic amine, including novel intermediates in this process, which carotenoids are known coloring agents for foodstuffs, animal feeds, pharmaceuticals, etc.Type: GrantFiled: July 1, 1988Date of Patent: November 28, 1989Assignee: Hoffmann-La Roche Inc.Inventors: Kurt Bernhard, Stephan Jaggli, Paul Kreienbuhl, Ulrich Schwieter
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Patent number: 4874898Abstract: Substituted anthrasteroid derivatives represented by the following formula: ##STR1## wherein R is hydrogen or lower alkyl; X is hydrogen, lower alkyl, halogen, hydroxy, hydroxymethyl, or halomethyl; Y is C.dbd.O, CH.about.OR', or OH C R", wherein R' is hydrogen, lower alkyl, cycloalkyl which may have an unsaturated bond or a substituent, or aliphatic lower acyl which may have carboxy or its lower alkyl ester at the terminal; R" is lower alkyl or lower alkynyl; the dotted line indicates the presence or absence of double bond; and the wavy line indicates .alpha. or .beta. configuration; or ketal derivatives thereof being effective against androgen-dependent diseases e.g., prostatic hypertrophy, prostatic cancer.Type: GrantFiled: July 7, 1988Date of Patent: October 17, 1989Assignee: Shionogi and Co., Ltd. Patent DepartmentInventors: Ken'ichi Takeda, Isao Horibe
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Patent number: 4846883Abstract: New succinic acid derivatives of the formula ##STR1## wherein A represents hydrogen, a naphthoxyethyl group of formula (b), ##STR2## or a substituted phenoxyethyl group of the formula ##STR3## and in this latter formula R stands for hydrogen or C.sub.1-4 alkyl,R.sup.1 is hydrogen, halo or C.sub.1-4 alkyl, andR.sup.2 and R.sup.3 each stand for hydrogen or halo,and agriculturally acceptable salts thereof are prepared by reacting succinic anhydride with an aryloxyethanol of the formula ##STR4## The new succinic acid drivatives of the formula (I) possess plant growth regulating properties.Type: GrantFiled: January 30, 1987Date of Patent: July 11, 1989Assignee: Reanal FinomvegyszergyarInventors: Gyorgy Matolcsy, Gyula Kerekes, Tamas Buban, Endre Vasarhelyi, Magda, nee Kalman Kovacs, Ivan Belai, Gerlei, Aniko, nee Komaromy
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Patent number: 4772743Abstract: Reaction products of 1 mole 2,2-bis-(4-hydroxycyclohexyl)-propanes with 2 moles carboxylic acid anhydrides and their use as emulsifiers for emulsion polymerization.Type: GrantFiled: November 9, 1987Date of Patent: September 20, 1988Assignee: Bayer AktiengesellschaftInventors: Adolf Schmidt, Herbert Eichenauer, Alfred Pischtschan
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Patent number: 4714775Abstract: The invention relates to novel phenylcyclohexyl dicarboxylates usable as liquid crystals or for improving the elastic properties of nematic liquid crystals.These compounds are in accordance with formula (I) ##STR1## in which R.sup.1 and R.sup.2, which can be the same or different, represent a hydrogen atom or an alkyl radical having 1 to 12 carbon atoms and n is an integer between 2 and 16.They can be prepared by reacting the diacid of formula HOOC(CH.sub.2).sub.n --COOH with corresponding substituted phenylcyclohexanols.Type: GrantFiled: October 1, 1986Date of Patent: December 22, 1987Assignee: Commissariat a l'Energie AtomiqueInventor: Anne-Marie Giroud
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Patent number: 4675341Abstract: The invention relates to novel [(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]ethanol , its derivatives, and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections including that due to AIDS virus, various brain concussions and elevated intracranial pressure.Type: GrantFiled: August 13, 1986Date of Patent: June 23, 1987Assignee: Merck & Co., Inc.Inventor: Edward J. Cragoe, Jr.
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Patent number: 4661149Abstract: The invention relates to certain substituted phenoxypropionaldehyde derivatives, formulations of said derivatives and the use thereof for preemergence or postemergence control of noxious plants, i.e., weeds.Type: GrantFiled: November 12, 1985Date of Patent: April 28, 1987Assignee: PPG Industries, Inc.Inventor: Muppala S. Raju
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Patent number: 4530934Abstract: There are described a new pharmaceutically active derivative of ursolic acid, 3.beta.-(3-carboxypropionyloxy)ursa-9(11),12-dien-28-oic acid, which possesses activity as an anti-ulcer and anti-viral agent, pharmaceutically acceptable, non-toxic salts thereof, a method of preparing the same and compositions containing the same.Type: GrantFiled: July 25, 1983Date of Patent: July 23, 1985Assignee: I.S.F. SpaInventors: Gaetano Clavenna, Carlo Farina, Mario Pinza, Giorgio Pifferi
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Patent number: 4515974Abstract: Fumaric acid monoesters can be prepared by introducing a hydroxyl compound at a rate corresponding to the progress of the reaction into a solution or a melt of maleic anhydride, which may optionally be substituted, if appropriate in the presence of a cis-trans catalyst. New fumaric acid monoesters can be formed by the process.Type: GrantFiled: June 25, 1982Date of Patent: May 7, 1985Assignee: Bayer AktiengesellschaftInventors: Wilfried Zecher, Rudolf Merten
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Patent number: 4511731Abstract: Preparation of monoethers of dihydroxybenzenes from an isopropenylphenol and an alkylating agent and thereafter oxidizing in the presence of an acid catalyst.Type: GrantFiled: June 24, 1983Date of Patent: April 16, 1985Assignee: The Dow Chemical CompanyInventors: Abel Mendoza, Eric W. Otterbacher
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Patent number: 4506091Abstract: A process for preparing esters which comprises reacting a polycarboxylic acid with an excess of alcohol and in the presence of an organotitanate catalyst, treating the crude mixture with a suitable chelate compound, removing the unreacted alcohol and hydrolyzing the treated titanium catalyst residues with steam, and recovering the purified ester by filtration.Type: GrantFiled: September 1, 1983Date of Patent: March 19, 1985Inventor: Donald L. Deardorff
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Patent number: 4474806Abstract: Sulfonyl or carbonyl derivatives of inositols are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These inositol derivatives are prepared by condensation of a protected inositol with a substituted sulfonic or carboxylic acid derivative followed by removal of protecting groups.Type: GrantFiled: May 10, 1982Date of Patent: October 2, 1984Assignee: Merck & Co., Inc.Inventors: Thomas R. Beattie, Shu S. Yang
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Patent number: 4457868Abstract: A method for conducting transesterification reactions employing a catalyst system comprising metallic sodium and aluminum isopropoxide which provides a facile, high yield, means for producing compounds such as esters of alkyl- and alkyloxy-substituted arylamines.Type: GrantFiled: September 2, 1981Date of Patent: July 3, 1984Assignee: Mobil Oil CorporationInventor: Milton Braid
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Patent number: 4448788Abstract: 11-Deoxoglycyrrhetinic acid hydrogen maleate of the following formula ##STR1## and its salts, and this compound is prepared by reacting 11-deoxoglycyrrhetinic acid with maleic anhydride, and if desired, converting the resulting 11-deoxoglycyrrhetinic acid hydrogen maleate to its salt. The compound is useful as medicament for treating an ulcer or inflammation in man or another animal or activating the cellular immunity of man or the animal.Type: GrantFiled: July 1, 1982Date of Patent: May 15, 1984Assignee: Maruzen Pharmaceutical Co., Ltd.Inventors: Shigeshi Toyoshima, Hajime Fujimura, Shunsuke Ito, Yasuji Kondo
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Patent number: 4438045Abstract: A new composition of matter is revealed.The composition of matter is the condensation product of succinic anhydride, 3-dimethylamino propylamine or 3-dimethyl aminoethanol and a specified glycidyl ether.The composition of matter is useful as an amphoteric surfactant.Type: GrantFiled: December 15, 1982Date of Patent: March 20, 1984Assignee: Texaco Inc.Inventors: Edward C. Y. Nieh, Carter G. Naylor
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Patent number: 4410461Abstract: A catalytic homogeneous liquid phase process for effecting the acyloxylation of toluene to produce the corresponding benzylic ester. The catalyst system comprises Pd(II) and Pb(II) values wherein the palladous element component is associated with a catalytic amount of a tertiary phosphine as a complexed ligand. The indicated catalyst system uniquely facilitates the advantageous use of normally immiscible carboxylic acid reactants for carrying out the underlying benzylic oxidation reaction.Type: GrantFiled: September 18, 1981Date of Patent: October 18, 1983Assignee: Ashland Oil, Inc.Inventor: Peter E. Throckmorton
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Patent number: 4386103Abstract: Dichloroamino acid derivatives other than .alpha.-dichloroamino acids are prepared from chlorination of corresponding amino acids, and are found to be potent germicidal and fungicidal agents.Type: GrantFiled: January 30, 1981Date of Patent: May 31, 1983Assignee: Merck & Co., Inc.Inventors: Stefano A. Pogany, Takeru Higuchi
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Patent number: 4363817Abstract: Disclosed are C-9 enol acylate analogs of E.sub.1 and E.sub.2 prostaglandins which are variously useful as bronchodilators, gastric anti-secretory agents and cyto-protective agents.Type: GrantFiled: August 27, 1981Date of Patent: December 14, 1982Assignee: Miles Laboratories, Inc.Inventor: William G. Biddlecom
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Patent number: 4312995Abstract: This invention relates to copolymerizable ultraviolet light absorber monomers which are .alpha.,.beta.-unsaturated dicarboxylic half-esters of 2-hydroxy,alkoxy,methylolbenzophenone intermediate compounds. The monomers have the formula: ##STR1## where R is alkyl C.sub.1 -C.sub.8, and n is 1 or 2, andY is a half-acyl radical of a .alpha.,.beta.-unsaturated dicarboxylic acid selected from the group of maleic and itaconic acids.The monomers herein are made by monoesterifying intermediate compounds, prepared by converting a 2-hydroxy,alkoxy,benzophenone to the corresponding methylol derivative by a formylation reaction, with the anhydride of the desired acid.In the preferred embodiments of the invention, the alkoxy group is methoxy in the 4-position, the methylol group which is half-esterified is a monomethylol group located at the 3- or 5- position of the phenyl ring containing the hydroxy group, and the acid anhydride is maleic anhydride.Type: GrantFiled: July 10, 1980Date of Patent: January 26, 1982Assignee: GAF CorporationInventors: Eugene S. Barabas, Prakash Mallya, Stanley J. Gromelski, Jr.
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Patent number: RE34805Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.Type: GrantFiled: July 10, 1992Date of Patent: December 6, 1994Assignee: Centre International de Recherches Dermatologiques (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon