Plural Rings Bonded Directly To The Same Acyclic Carbon In Acid Moiety Patents (Class 560/57)
  • Patent number: 4605785
    Abstract: The invention relates to new 1,1-diphenylpropan-1-ol derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,R.sub.3 is halogen, trihalomethyl, alkyl having from one to 5 carbon atoms or alkoxy having from one to 5 carbon atoms,R.sub.4 is phenyl optionally substituted by one or more identical or different substituents selected from the group of halogen, trihalomethyl, alkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, hydroxyl, carboxyl or substituted carboxyl; dialkylaminocarbonyl or alkoxycarbonyl containing from one to 4 carbon atoms in the alkyl and alkoxy moieties, respectively,n is 1, 2, 3, 4, or 5.According to another aspect of the invention there are provided processes for the preparation of the compounds of formula (I).
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: August 12, 1986
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szabolcs Szeberenyi, Laszlo Szporny, Sandor Gorog, Istvan Hajdu
  • Patent number: 4594444
    Abstract: If the transesterification of esters of the formula II ##STR1## with alcohols of the formula III ##STR2## is catalyzed by treatment with catalytic amounts of an oxide or an organo-metallic compound of a metal of the fourth main group or subgroup of the periodic system, and if the resulting melt is then distilled in a flash distillation apparatus under specific conditions, compounds of the formula ##STR3## are obtained in a virtually quantitative yield. In the above formulae, R is methyl or ethyl, A is a radical of an m-hydric aliphatic alcohol, E is methyl or tert-butyl, m is 1 to 4 and n is 0 to 2. The products thus obtained do not contain any interfering by-products and do not have to be additionally purified.
    Type: Grant
    Filed: December 12, 1984
    Date of Patent: June 10, 1986
    Assignee: Ciba-Geigy Corporation
    Inventor: Ivan Orban
  • Patent number: 4590301
    Abstract: Compounds of the general formula ##STR1## wherein n, R.sub.1, R.sub.2 and X are defined herein, are effective inhibitors of polymerization of vinylic monomers, particularly acrylic monomers. The inhibitors are easily, efficiently, and thoroughly removed from solution with the monomer by contact with charcoal.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: May 20, 1986
    Assignee: Barnes-Hind, Inc.
    Inventors: Drahoslav Lim, Peter C. Morris
  • Patent number: 4582924
    Abstract: An .alpha.-fluoroalkyl carboxylic acid ester of the general formula ##STR1## wherein A is R.sup.1 R.sup.2 COR.sup.3 -- or R.sup.4 CO--, wherein R.sup.1 and R.sup.2 are independently hydrogen, alkyl, alkoxyl or phenyl, with or without the formation of a common ring therebetween, R.sup.3 is hydrogen or alkyl, R.sup.4 and R are independently alkyl, and R.sub.f is fluoroalkyl. The .alpha.-fluoroalkyl carboxylic acid ester is prepared by reacting a fluoroalkyl silyl ketene acetal of the formula ##STR2## wherein R' is alkyl and R.sub.f and R are the same as defined above, with the corresponding acetal, ketone or acyl halide.
    Type: Grant
    Filed: March 7, 1984
    Date of Patent: April 15, 1986
    Assignee: Daikin Kogyo Co., Ltd.
    Inventors: Nobuo Ishikawa, Takeshi Nakai
  • Patent number: 4556676
    Abstract: Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • Patent number: 4552977
    Abstract: Process for the preparation of (phenoxy- or benzyl-)-phenoxypropionic acids and the alkali metal salts thereof by adding a double molar amount of an aqueous alkali hydroxide to a boiling mixture of a (benzyl- or phenoxy-)-phenol and 2-chloropropionic acid (ester), with simultaneous azeotropic distillation of the water introduced or formed in the reaction.
    Type: Grant
    Filed: September 24, 1982
    Date of Patent: November 12, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Koch, Peter Herbrechtsmeier
  • Patent number: 4515808
    Abstract: Pesticidal compounds have the formula: ##STR1## wherein D represents hydrogen or a cyano group or an ethynyl group R.sub.a represents alkylA represents an alkyl group or a halogeno or trifluoromethyl groupn is 0 or an integer of 1-4, b is 0 or 1andRCOO is the residue of an acid RCOOH whose .alpha.-cyano-3-phenoxybenzyl ester has pesticidal properties. They are prepared by esterification methods.
    Type: Grant
    Filed: July 26, 1983
    Date of Patent: May 7, 1985
    Assignee: National Research Development Corporation
    Inventors: Michael Elliott, Norman F. Janes, Bhupinder P. S. Khambay
  • Patent number: 4483999
    Abstract: Novel compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, or alkyl or alkoxy containing from 1 to 4 carbon atoms,R.sup.2 is hydrogen, halogen, hydroxy or alkyl of alkoxy containing from 1 to 4 carbon atoms,n and m are integers such that the sum (n+m) lies in the range from 3 to 10 inclusive and n differs from m, andx is alkyl containing from 1 to 4 carbon atoms, hydrogen or a cation which is a metal cation of main Groups 1, 2 and 3 of the Periodic System of the Elements, an organic base cation or an ammonium ion. These compounds have pharmaceutical utility by virtue of their considerable ability to reduce the level of fatty substances in the blood.
    Type: Grant
    Filed: March 1, 1977
    Date of Patent: November 20, 1984
    Assignee: Siegfried Aktiengesellschaft
    Inventors: Kurt Thiele, Quazi Ahmed, Rudolf Adrian, Ulrich Jahn
  • Patent number: 4461912
    Abstract: Phenylacetic derivatives of formula (I): ##STR1## (wherein R represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and n represents an integer from 1 to 3) and salts and esters thereof have analgesic, antipyretic and anti-inflammatory activity and may be prepared by reducing the corresponding acid or ester having an oxo group at the 2-position of the cycloalkylidene ring system and, if necessary, salifying the resulting product.
    Type: Grant
    Filed: December 6, 1982
    Date of Patent: July 24, 1984
    Assignee: Sankyo Company Limited
    Inventors: Atsusuke Terada, Shunji Naruto, Eiichi Misaka
  • Patent number: 4424166
    Abstract: In the preparation of a 1,1-dihalogenoalkene of the formula ##STR1## in which R.sup.1 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, orR.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain, andX.sup.1 and X.sup.2 each independently is a halogen atom,wherein a carbonyl compound of the formula ##STR2## is reacted with a trihalogenoacetate of the formula ##STR3## in which X.sup.3 is a halogen atom, andM.sup..sym. is an alkali metal ion or one equivalent of an alkaline earth metal ion,in the presence of an approximately equimolar amount of a phosphorus-containing compound, the improvement which comprises employing as said phosphorus-containing compound a phosphorous acid trialkyl ester or a phosphorous acid triamide and effecting the reaction at a temperature between about 0.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: January 3, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Fritz Maurer, Uwe Priesnitz, Hans-Jochem Riebel
  • Patent number: 4417071
    Abstract: A process for the manufacture of phenols of the formula I ##STR1## wherein R.sub.1 is alkyl of 1 to 18 carbon atoms, cycloalkyl, phenyl, aralkyl or chlorine, R.sub.2 is hydrogen or has the same meaning as R.sub.1, R.sub.3 is hydrogen or alkyl of 1 to 12 carbon atoms, R.sub.4 is alkylene of 2 to 18 carbon atoms which is unsubstituted or substituted by aryl or hydroxyl, and n is an integer from 0 to 4, which process comprises transesterifying a compound of the formula II ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined for formula (I) and R.sub.5 is alkyl of 1 to 4 carbon atoms with a mercapto alcohol of the formulaHO--R.sub.4 --SHwherein R.sub.4 is as defined for formula (I), in the presence of a catalyst of the formula (R.sub.6 O).sub.4 M, wherein R.sub.6 represents alkyl radicals of 1 to 18 carbon atoms which can be the same or different, aryl or alkaryl, and M is an element selected from the group consisting of Ti, Ge, Zr, Sn or V.
    Type: Grant
    Filed: March 11, 1982
    Date of Patent: November 22, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Siegfried Rosenberger
  • Patent number: 4409397
    Abstract: Tetra-substituted olefinic acids and derivatives of the formula ##STR1## wherein R is --COOM in which M is a cation forming a soluble salt or --COOR.sup.4 or --CON(R.sup.4).sub.2 in which each R.sup.4 is independently a hydrogen atom or an alkyl group; R.sup.1 is an optionally substituted alkyl, cycloalkyl, aryl or heterocyclic group; and R.sup.2 or R.sup.3 each independently is an optionally substituted alkyl or cycloalkyl group or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached form a carbocyclic ring, are asymmetrically hydrogenated in the presence of a coordinated complex of rhodium, iridium, or ruthenium in combination with a chiral metallocenylphosphine or pyrrolidinylphosphine ligand.
    Type: Grant
    Filed: May 6, 1982
    Date of Patent: October 11, 1983
    Assignee: Shell Oil Company
    Inventor: Timm E. Paxson
  • Patent number: 4400534
    Abstract: Compounds of formula (I): ##STR1## its salts, and resolved forms thereof, especially the compound of formula (II): ##STR2## and its salts are new analgesic and/or anti-inflammatory agents. The agents are prepared by resolution at the 2-position of a suitable starting material such as the compound (IV): ##STR3## or an optionally partly resolved form thereof, with subsequent reduction and optional resolution to give the trans form.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: August 23, 1983
    Assignee: Sankyo Company, Limited
    Inventors: Atsusuke Terada, Eiichi Misaka
  • Patent number: 4377593
    Abstract: The invention relates to .alpha.-isopropyl- and .alpha.-cyclopropylphenylacetates of the formula ##STR1## wherein R.sub.1 is hydrogen, cyano, --CSNH.sub.2, allenyl, C.sub.2 -C.sub.3 alkenyl or C.sub.2 -C.sub.3 alkynyl, R.sub.2 is unsubstituted or substituted alkenyl or alkynyl, R.sub.3 is isopropyl or cyclopropyl, and each of R.sub.4 and R.sub.5 is halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, or both together are the methylenedioxy radical.A process for the production of these compounds and their use in pest control are disclosed.
    Type: Grant
    Filed: February 19, 1982
    Date of Patent: March 22, 1983
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Ackermann, Laurenz Gsell, Rudolf Wehrli
  • Patent number: 4360690
    Abstract: 1-Aryl-cyclopropane-1-carboxylic acid esters of the formula ##STR1## in which R.sup.1 represents a hydrogen atom, a cyano radical or an alkyl, alkenyl or alkinyl radical within each case up to 7 carbon atoms, andR.sup.2 represents a phenyl radical which is substituted by halogen and/or optionally halogen-substituted phenoxy, with the proviso that the radical R.sup.2 in total contains at least one fluorine substituent,R.sup.3 and R.sup.4, which can be identical or different, represents a fluorine, chlorine or bromine atom or a methyl radical,R.sup.5 represents a hydrogen or halogen atom or a methyl or methoxy radical, andR.sup.6 represents a hydrogen or halogen atom, a cyano nitro or amino radical or an optionally halogen-substituted radical selected from C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy and C.sub.1 to C.sub.4 alkylthio,or whereinthe two radicals R.sup.5 and R.sup.6 together represent an optionally halogen-substituted C.sub.1 or C.sub.
    Type: Grant
    Filed: June 12, 1981
    Date of Patent: November 23, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rainer Fuchs, Klaus Naumann, Ingeborg Hammann, Bernhard Homeyer, Wolfgang Behrenz, Wilhelm Stendel
  • Patent number: 4350824
    Abstract: A process for the preparation of a 1,1-dichloroalkene of the formula ##STR1## in which R.sup.1 is hydrogen, or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, orR.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain,comprising reacting a carbonyl compound of the formula ##STR2## with a trichloromethanephosphonic acid ester of the formula ##STR3## in which R.sup.3 each individually is an alkyl or phenyl radical, or the two radicals R.sup.3 together are alkanediyl,in the presence of at least an equimolar amount of a phosphorous acid triamide of the formulaP(NR.sup.4.sub.2).sub.3in whichR.sup.4 each independently is an alkyl radical, or the two radicals R.sup.4 together are alkanediyl.Advantageously,R.sup.1 is hydrogen,R.sup.2 a C.sub.2 to C.sub.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: September 21, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Jochem Riebel, Fritz Maurer, Uwe Priesnitz
  • Patent number: 4344961
    Abstract: Novel carboxylic acid esters of the formula ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and each is hydrogen, halogen or alkyl or alkenyl of up to 5 carbon atoms,Y is 3-(2,2-dihalogenovinyl)-2,2-dimethyl-cyclopropyl or a radical of the formula ##STR2## where R.sup.4 is unbranched or branched alkyl, alkenyl or alkynyl of up to 4 carbon atoms or is an alicyclic radical of 3 to 7 carbon atoms,R.sup.5 is halogen, alkyl or alkoxy of up to 5 carbon atoms, trihalomethyl, cyano or nitro anda is from 0 to 3 andZ is a radical of the formula ##STR3## where X is oxygen, sulfur or --CH.sub.2 --,R.sup.6, R.sup.7 and R.sup.8 are halogen or alkyl, alkoxy or haloalkyl of up to 5 carbon atoms andb, c and d are from 0 to 3, their preparation and their use in insect and arachnid control.
    Type: Grant
    Filed: February 9, 1981
    Date of Patent: August 17, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd-Ulrich Schwarz, Karl Kiehs, Heinrich Adolphi
  • Patent number: 4310465
    Abstract: A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: January 12, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gary L. Olson, Gabriel Saucy
  • Patent number: 4288607
    Abstract: The invention relates to halogenous polyesters with the recurrent general formula ##STR1## in which at least part of the R's, e.g.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: September 8, 1981
    Assignee: Dynamit Nobel Aktiengesellschaft
    Inventors: Gerhard Bier, Dagmar Kottek, Egon N. Petersen, Hermann Richtzenhain, Norbert Vollkommer
  • Patent number: 4284643
    Abstract: Fluorine-containing phenylacetic acid esters of the formula ##STR1## in which R represents the radical of an alcohol customary in the case of pyrethroids,R.sup.1 represents C.sub.2-4 -alkyl, C.sub.2-4 -alkenyl or cyclopropyl,X represents H, halogen, alkyl, alkoxy, OCHF.sub.2, SCHF.sub.2, SCClF.sub.2 or SCF.sub.3 andX.sup.1 can vary widely or form a fused ring with X,the overall compound necessarily containing a fluorine atom, which compounds possess arthropodicidal properties. Intermediates therefor and an overall synthesis from an alcohol of the formula ROH and a toluene of the formula ##STR2## are also shown.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: August 18, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rainer Fuchs, Erich Klauke, Ingeborg Hammann, Bernhard Homeyer, Wolfgang Behrenz, Wilhelm Stendel, Reinhard Lantzsch, Albrecht Marhold
  • Patent number: 4283414
    Abstract: The invention concerns novel pesticidal esters of the pyrethrin or pyrethroid type in which the methylene group bonded to the ester carbonyl and/or ester oxygen bears a fluorine substituent. The compounds of the invention are active against insect pests including flies, moths, aphids and beetles and acarina pests including ticks.
    Type: Grant
    Filed: June 8, 1979
    Date of Patent: August 11, 1981
    Assignee: ICI Australia Limited
    Inventors: Donald W. G. Harney, Peter G. Lehman, Joseph C. Rundle
  • Patent number: 4271186
    Abstract: The invention relates to certain new stilbene derivatives of the general formula ##STR1## in which R, R.sup.1 and R.sup.2 have the below mentioned meaning, to a process for their preparation and to their use as arthropodicides, especially as insecticides and acaricides.
    Type: Grant
    Filed: June 29, 1979
    Date of Patent: June 2, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Forster, Rainer Fuchs, Ingeborg Hammann, Wilhelm Stendel
  • Patent number: 4266074
    Abstract: Substituted acetate compounds represented by the formula ##STR1## which are useful as pesticides and pesticidal composition containing the substituted acetate compounds as active ingredients, as well as processes for preparing the compounds and the compositions are disclosed.
    Type: Grant
    Filed: July 16, 1975
    Date of Patent: May 5, 1981
    Assignee: Sumitomo Chemical Company Limited
    Inventors: Keimei Fujimoto, Nobuo Ohno, Yoshitoshi Okuno, Toshio Mizutani, Isao Ohno, Masachika Hirano, Nobushige Itaya, Takashi Matsuo
  • Patent number: 4252980
    Abstract: (Phenoxy- or benzyl)-phenoxypropionic acid methyl esters are produced by esterification of the corresponding anhydrous alkali metal salts with half the molar amount of dimethyl sulfate at a temperature exceeding 120.degree. C.
    Type: Grant
    Filed: October 2, 1979
    Date of Patent: February 24, 1981
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Koch, Hilmar Mildenberger
  • Patent number: 4246426
    Abstract: 11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: January 20, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: George W. Holland, Jane L. Jernow, Perry Rosen
  • Patent number: 4234742
    Abstract: Compounds of the formula: ##STR1## in which A is a methylene group, sulphur or a disulphide bridge, R is a hydrogen atom or a methyl group, R.sub.1 is a linear or branched alkyl group having 1 to 4 carbon atoms, and R.sub.2 is an alkyl group having 1 to 4 carbon atoms, or a halogen atom, or an alkoxy group, and their pharmaceutically acceptable salts have a valuable hypocholesterolemia-inducing activity.
    Type: Grant
    Filed: June 5, 1979
    Date of Patent: November 18, 1980
    Assignee: Hexachimie
    Inventors: Jean C. Cognacq, Jean Lacrampe
  • Patent number: 4227019
    Abstract: 11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: October 7, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: George W. Holland, Jane L. Jernow, Perry Rosen
  • Patent number: 4214095
    Abstract: Novel compounds of the formula (1) ##STR1## wherein R.sup.1 and R.sup.2 are different lower alkyls and R.sup.3 is a lower alkyl or a methyl pyridine group, and the acid addition salts of formula (1) compounds when R.sup.3 is methyl pyridine. The novel compounds have an asymmetric C-atom and may be in the form of the D,L racemates or the D or L stereoisomers.These compounds are useful in the treatment of hypercholesterolemia and hyperlipidemia because of their high effectiveness in reducing the level of cholesterol and lipids in the blood combined with very low general toxicities and substantially reduced hepatomegalitic effects.
    Type: Grant
    Filed: January 25, 1979
    Date of Patent: July 22, 1980
    Assignee: Siegfried Aktiengesellschaft
    Inventors: Kurt Thiele, Quazi Ahmed, Rudolf Adrian, Ulrich Jahn
  • Patent number: 4205087
    Abstract: Novel di-(substituted phenyl)methoxy acetic acids, alkyl homologues and related salts, ester and amides thereof, together with processes for their manufacture, and pharmaceutical compositions. A representative compound is di-(4-chlorophenyl)methyloxy acetic acid. The compounds possess anti-arthritic properties and in some cases, in addition, an effect on a factor involved in atherosclerotic disease.
    Type: Grant
    Filed: April 26, 1977
    Date of Patent: May 27, 1980
    Assignee: Imperial Chemical Industries Limited
    Inventor: Wilson S. Waring
  • Patent number: 4183942
    Abstract: New insecticidal (.beta.-phenyl-.beta.-substituted-vinyl)cyclopropanecarboxylates in which the .beta.-substituent may be halogen or lower haloalkyl are described and their preparation and insecticidal utility are exemplified.
    Type: Grant
    Filed: October 23, 1978
    Date of Patent: January 15, 1980
    Assignee: FMC Corporation
    Inventor: John F. Engel
  • Patent number: 4171371
    Abstract: Beta-diketones substituted by an aryl-aliphatic group in which the aliphatic chain is interrupted by a cyclic group, and useful as anti-viral agents, are prepared by interacting the appropriate aryl-aliphatic halide with an alkali metal salt of a beta-diketone.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: October 16, 1979
    Assignee: Sterling Drug Inc.
    Inventor: Guy D. Diana
  • Patent number: 4163016
    Abstract: 16-Substituted prostaglandins position and the 16-substituted-15-keto prostaglandins, said prostaglandins being useful as antisecretory agents, blood pressure lowering agents, anti-ulcerogenic agents and antihypertensive agents.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: July 31, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: George W. Holland, Perry Rosen
  • Patent number: 4153803
    Abstract: Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms;A.sup.1 and A.sup.2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A.sup.1 and A.sup.
    Type: Grant
    Filed: March 1, 1977
    Date of Patent: May 8, 1979
    Assignee: Siegfried Aktiengesellschaft
    Inventors: Kurt Thiele, Quazi Ahmed, Rudolf Adrian, Ulrich Jahn
  • Patent number: 4153719
    Abstract: Beta-diketones substituted by an aryl-aliphatic group in which the aliphatic chain is interrupted by a cyclic group, and useful as anti-viral agents, are prepared by interacting the appropriate aryl-aliphatic halide with an alkali metal salt of a beta-diketone.
    Type: Grant
    Filed: September 6, 1977
    Date of Patent: May 8, 1979
    Assignee: Sterling Drug Inc.
    Inventor: Guy D. Diana
  • Patent number: 4152511
    Abstract: The invention relates to halogenous polyesters with the recurrent general formula ##STR1## in which at least part of the R's, e.g.
    Type: Grant
    Filed: October 19, 1976
    Date of Patent: May 1, 1979
    Assignee: Dynamit Nobel Aktiengesellschaft
    Inventors: Gerhard Bier, Dagmar Kottek, Egon N. Petersen, Hermann Richtzenhain, Norbert Vollkommer
  • Patent number: 4146385
    Abstract: The invention provides novel phenoxyalkylcarboxylic acids which are useful in therapy as metabolic regulators and in agriculture as selective herbicides.
    Type: Grant
    Filed: August 16, 1976
    Date of Patent: March 27, 1979
    Assignee: Societe de Recherches Industrielles S.O.R.I.
    Inventor: Bernard Majoie
  • Patent number: 4137324
    Abstract: New insecticides are of general formula: ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 represent H or methyl, R.sup.6 represents alkyl, alkoxy, halogeno or nitro or two R.sup.6 groups together represent methylenedioxy, and R is a group forming insecticidal esters with chrysanthemic acid such as 5-benzyl-3-furylmethyl, 3-phenoxybenzyl or .alpha.-cyano-3-phenoxybenzyl. They are prepared by esterification methods.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: January 30, 1979
    Assignee: National Research Development Corporation
    Inventors: Michael Elliott, Norman F. Janes, David A. Pulman
  • Patent number: 4093592
    Abstract: 2,2-BIS-(ALKYL-4'-HYDROXYPHENYL)-CYCLOALKYL-(ALKYL) CARBONIC ACID ESTERS ARE PREPARED BY CONDENSATION OF ALKYL PHENOLS WITH 2-KETO-CYCLOALKYL CARBONIC ACID ESTERS IN THE PRESENCE OF ACIDIC CATALYSTS AND OPTIONALLY OF MERCAPTO DERIVATIVES. The product are useful for the stabilization of polymers against the decomposition by light and heat.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: June 6, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Mayer, Gerhard Pfahler, Hartmut Wiezer
  • Patent number: 4091111
    Abstract: A novel substituted-arylacetic acid ester of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or a halogen atom, a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxy, cyano, nitro, methylthio, C.sub.1 -C.sub.4 alkanoyl, C.sub.1 -C.sub.4 alkanoyloxy, or C.sub.1 -C.sub.4 alkoxycarbonyl group, or R.sub.1 and R.sub.2, taken together, may form methylenedioxy, a C.sub.3 -C.sub.5 alkylene or butadienylene (--CH.dbd.CH--CH.dbd.CH--) ring; R.sub.3 is a C.sub.2 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, propargyl, C.sub.3 -C.sub.6 cycloalkyl or cyclopropylmethyl group; R.sub.4 is hydrogen or a halogen atom, methyl or ethyl group; R.sub.5 is allyl, propargyl, 3-butenyl, 3-butynyl, phenyl or benzyl group; and A is oxygen or sulfur atom or --CH.dbd.CH-- group, which possesses various useful insecticidal and acaricidal activities and can be prepared by reacting a substituted-arylacetic acid of the formula; ##STR2## wherein R.sub.1, R.sub.2, R.sub.
    Type: Grant
    Filed: October 1, 1976
    Date of Patent: May 23, 1978
    Assignee: Sumitomo Chemical Company Limited
    Inventors: Nobuo Ohno, Isao Ohno, Toshio Nishioka, Hisami Takeda, Kiyoshi Kasamatsu
  • Patent number: 4088474
    Abstract: Compounds of the formula ##STR1## WHEREIN R is halogen, (C.sub.1 -C.sub.4)alkyl, halo-(C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, halo(C.sub.1 -C.sub.4)alkoxy, phenyl, --NO.sub.2, --NH.sub.2 or --CN;R' is (C.sub.1 -C.sub.4)alkyl or halogen;n is an integer of from 1 to 3;n.sub.1 is zero or an integer of from 1 to 3;Y is (C.sub.1 -C.sub.6)alkylene andX is --COOH, --COO--(C.sub.1 -C.sub.8)alkyl, --CONH.sub.2, --CONH--NH.sub.2, --CN or --COO--Cat,"Cat" being the cation of an inorganic or organic base, are useful as selective grass herbicides.
    Type: Grant
    Filed: April 8, 1975
    Date of Patent: May 9, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl Matterstock, Peter Langeluddeke, Ernst-Friedrich Schulze
  • Patent number: 4087463
    Abstract: Hydrogenolysis of hydrobenzoins [1,2-bis(aryl)ethane-1,2-diols] in the presence of a catalyst comprising cobalt carbonyl yields 1,2-bis(aryl)ethanes. The process is particularly directed to the production of 1,2-bis(4-hydroxyphenyl)ethane from 4,4-dihydroxyhydrobenzoin [1,2-bis(4-hydroxyphenyl)ethane-1,2-diol].
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: May 2, 1978
    Assignee: Monsanto Company
    Inventors: Denis Forster, George F. Schaefer
  • Patent number: 4073814
    Abstract: A method is provided for dehydrochlorinating 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane to produce substantially pure 1,1-dichloro-2,2-bis(4-hydroxyphenyl)ethylene, based on the employment of a dipolar aprotic solvent and a basic alkali metal compound, such as sodium hydroxide, sodium carbonate, etc. Crystallization of the 1,1-bis(p-hydroxyphenyl)-2,2-dichloroethylene from the dehydrochlorination reaction mixture can provide monomer useful for making high impact, flame retardant thermoplastic polycarbonates.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: February 14, 1978
    Assignee: General Electric Company
    Inventors: Philip L. Kinson, Clayton B. Quinn
  • Patent number: 4072705
    Abstract: Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: February 7, 1978
    Assignee: Orchimed S.A.
    Inventor: Andre Mieville
  • Patent number: 4069344
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 represents cyclohexyl, cyclohexyloxy or the ##STR2## BEING BONDED TO THE PHENYL NUCLEUS, R.sub.2 represents hydrogen, C.sub.1 -C.sub.3 -alkyl, R.sub.3 represents --COOH, (C.sub.1 -C.sub.5 -alkoxy)carbonyl, (C.sub.3 -C.sub.5 -alkenyloxy)carbonyl, (C.sub.3 -C.sub.5 -alkinyloxy)carbonyl, cyclohexyloxycarbonyl, phenoxycarbonyl, (C.sub.3 -C.sub.5 -haloalkenyloxy)carbonyl, the cyano group, a carbamoyl group which is mono- or disubstituted by C.sub.1 -C.sub.5 -alkyl, C.sub.3 -C.sub.5 -alkenyl or C.sub.3 -C.sub.5 -alkinyl, it being possible for the substituents of the carbamoyl group together with the nitrogen atom to which they are bonded to form a saturated 5- or 6-membered heterocyclic ring which can contain in addition an oxygen, a sulphur, or a further nitrogen atom, R.sub.4 represents hydrogen, methyl, or ethyl, R.sub.5 represents C.sub.1 -C.sub.3 -alkyl, formyl, or acetyl, R.sub.6 represents hydrogen or C.sub.1 -C.sub.3 -alkyl, R.sub.
    Type: Grant
    Filed: March 15, 1976
    Date of Patent: January 17, 1978
    Assignee: CIBA-GEIGY Corporation
    Inventor: Friedrich Karrer
  • Patent number: 4059576
    Abstract: 11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.
    Type: Grant
    Filed: September 17, 1975
    Date of Patent: November 22, 1977
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: George William Holland, Jane Liu Jernow, Perry Rosen
  • Patent number: 4052364
    Abstract: Bis(hydroxyphenyl)-alkanoic acid esters the phenyl radicals of which are alkylated twice are prepared by alkylation of corresponding compounds carrying one alkyl radical at the nucleus, using isobutylene as alkylating agent. The alkanoic acid esters are obtained in crystalline form and are suitable as stabilizers for polyolefins.
    Type: Grant
    Filed: January 30, 1975
    Date of Patent: October 4, 1977
    Assignees: Nobel Hoechst Chimie, Hoechst Aktiengesellschaft
    Inventors: Yani Christidis, Otto Mauz, Eberhard Prinz
  • Patent number: 4048065
    Abstract: For inhibiting corrosion and scale on ferrous metal parts in a circulating water system there is added to the water in such system from 10 to 500 ppm of a partial ester of a polyfunctional acid having a free carboxylate, phosphonate or sulfonate group and another carboxyl group which is esterified with a polyoxyalkylated derivative of an alkyl, alkaryl, or alkenyl alcohol having a terminal hydrocarbon group of 8-20 carbon atoms. In some preferred embodiments there is added with the partial ester from 10 to 500 ppm of a dispersible enhancing agent which may also include a surface active agent for dispersing the agent in water. Preferred partial esters include partial esters of citric, malic, tartaric, maleic, adipic and phthalic acids partially esterified with an alkyl polyoxyethylene alcohol having 2 to 4 ethoxy groups.
    Type: Grant
    Filed: July 17, 1975
    Date of Patent: September 13, 1977
    Assignee: American Cyanamid Company
    Inventors: Tzeng Jiueq Suen, Arthur James Begala, Jr., Martin Grayson
  • Patent number: 4048147
    Abstract: A novel compound represented by the formula, ##STR1## WHEREIN R is a hydrogen or an alkyl group having 1 to 3 carbon atoms, said four R's being the same or different; R.sup.1 is hydrogen, an alkali metal, an ammonium group, a mono-to tetra-hydric aliphatic alcohol moiety having 1 to 12 carbon atoms, or an organic amine residue; n is an integer of 1 to 4; and R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently hydrogen or alkyl groups having 1 to 6 carbon atoms or R.sup.2 and R.sup.3 may form a ring when taken together. Said novel compound has properties similar to those of natural rosin or a disproportionated rosin, and is useful as a vehicle for coating compositions and printing inks, as an emulsifier for emulsion polymerization, and as a sizing agent.
    Type: Grant
    Filed: November 26, 1975
    Date of Patent: September 13, 1977
    Assignee: Japan Synthetic Rubber Co., Ltd.
    Inventors: Masatoshi Arakawa, Ryotaro Ohno, Katuhiro Ishikawa, Noboru Yamahara, Hisashi Matsui