Acylated Patents (Class 560/66)
  • Patent number: 4830470
    Abstract: Compounds of the formula ##STR1## wherein m represents is the number 0 or 1; A is a single covalent bond, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --COO-- or --OOC--; rings B, C and D are 1,4-phenylene optionally substituted with cyano, halogen or lower alkyl; Y.sup.1 and Y.sup.2 are hydrogen or one of them also is cyano; and R.sup.1 and R.sup.2 each represents C.sub.1 -C.sub.18 -alkyl or C.sub.2 -C.sub.18 alkenyl, either of which is optionally halogen-substituted, in which one CH.sub.2 group or two non-adjacent CH.sub.2 groups is/are optionally replaced by oxygen; with the provisos that at least one of R.sup.1 and R.sup.2 has a chiral carbon atom or a C--C double bond or both when A is --COO-- and at least one of R.sup.1 and R.sup.2 has a C--C double bond when A is a single covalent bond, their preparation, liquid crystalline mixtures containing these compounds and their use for electro-optical purposes are described.
    Type: Grant
    Filed: May 20, 1987
    Date of Patent: May 16, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Buchecker, Hans-Jurgen Fromm, Stephen Kelly, Martin Schadt
  • Patent number: 4828754
    Abstract: A liquid crystalline compound represented by formula ##STR1## wherein R denotes an alkyl or alkoxy group having 1 to 20 carbon atoms,m and n are each 0 or 1, provided m and n are not 1 at the same time. ##STR2## X and Y each denote a hydrogen atom, a halogen atom or a nitro group, provided X and Y are not hydrogen atoms at the same time, and Q* denotes an optically active group having an asymmetric carbon atom and a linear or cyclic alkyl or alkenyl group which may be substituted by a halogen atom, or the like.
    Type: Grant
    Filed: February 23, 1988
    Date of Patent: May 9, 1989
    Assignees: Dainippon Ink & Chemicals, Inc., Kawamura Institute of Chemical Res.
    Inventors: Sadao Takehara, Toru Fujisawa, Yoshi Arai, Jitsuo Kurokawa
  • Patent number: 4826620
    Abstract: The new esters derived from a chiral compound containing two OH groups and at least one mesogenic carboxylic acid which have the general formula (I) ##STR1## in which X.sup.1 =O--H or O--CO--(C.sub.1 to C.sub.12)alkyl and X.sup.2 =O--MC or X.sup.1 and X.sup.2 denote O-MC independently of each other, where MC is the molecular radical of a mesogenic monocarboxylic acid after splitting off an OH group.The esters or esters substituted in the aromatic part of the phenolic part preferably find application as an admixture intwistable liquid crystal phases in which they produce a temperature compensation and a high degree of twisting.
    Type: Grant
    Filed: January 21, 1988
    Date of Patent: May 2, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerd Heppke, Detlef Lotzsch, Feodor Oestreicher, Gunter Scherowsky
  • Patent number: 4826876
    Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: May 2, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson
  • Patent number: 4812259
    Abstract: An optically active lactic acid derivative represented by the following formula (Ia) or (Ib): ##STR1## wherein R is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 1-16 carbon atoms, R.sup.1 is an alkyl group having 4-16 carbon atoms, m and n are respectively 1 or 2, k is 0 or 1, and C* is an asymmetric carbon atom. A liquid crystal composition containing the lactic acid derivative and a liquid crystal device using the liquid crystal composition are also disclosed.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: March 14, 1989
    Assignee: Canon Kabushiki Kaisha
    Inventors: Kazuo Yoshinaga, Kazuharu Katagiri, Kenji Shinjo
  • Patent number: 4780242
    Abstract: A novel optically active liquid crystal compound and a liquid crystal composition containing the same are provided, which compound is expressed by the formula ##STR1## wherein R.sub.1 is alkyl or alkoxy of 4-18 C; R.sub.2 is alkyl, alkoxy, acyl or alkoxymethyl of 4-18 C; but either one of R.sub.1 or R.sub.2 is an optically active group; either one of X.sub.1 or X.sub.2 is halogen atom and the other is H; m and n each are 0 or 1 and m+n is 0 or 1.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: October 25, 1988
    Assignee: Chisso Corporation
    Inventors: Kazutoshi Miyazawa, Hiromichi Inoue, Shinichi Saito, Takashi Inukai, Kanetsugu Terashima, Mitsuyoshi Inchihashi
  • Patent number: 4764637
    Abstract: The hydrated complex of magnesium acetylsalicylate and urea of formula ##STR1## possesses exceptional analgesic and antipyretic properties. It may be crystallized from a solution obtained by reacting acetylsalicylic acid with magnesium carbonate in the presence of urea.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: August 16, 1988
    Assignee: Rhone-Poulenc Sante
    Inventors: Claude Bertrand, Gerard Wolff
  • Patent number: 4764619
    Abstract: An optically active compound having the formula: ##STR1## wherein each of Z and Z' is a single bond, --COO--, --OCO--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 -- or --CH.sub.2 O--, R is an alkyl group having from 1 to 12 carbon atoms, an alkoxyl group having from 1 to 12 carbon atoms, a cyano group or a halogen atom, each of rings A and B is a 1,4-di-substituted phenylene group or a trans-1,4-di-substituted cyclohexylene group, n is 0 or 1, X is ##STR2## wherein * indicates an optical center, and R' is an alkyl group having from 2 to 12 carbon atoms or ##STR3## where R" is a hydrogen atom, an alkyl or alkoxy group having from 1 to 12 carbon atoms, provided that when X is ##STR4## R is the alkyl group or the alkoxy group.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: August 16, 1988
    Assignee: Asahi Glass Company Ltd.
    Inventors: Tomoki Gunjima, Ryutaro Takei, Eriko Aoyama
  • Patent number: 4743704
    Abstract: Esters of salsalate with guaiacol for treatment of phlogistic bronchopneumopathies, having the following general formula: ##STR1## in which R is H or CH.sub.3 CO. Said esters combine antiphlogistic and antitussive therapeutic characteristics with high stability at gastric pH.
    Type: Grant
    Filed: June 19, 1987
    Date of Patent: May 10, 1988
    Assignee: FINTECO Srl
    Inventor: Marino Nicolini
  • Patent number: 4739097
    Abstract: Compounds of the general formula I ##STR1## in which R is a hydrogen or halogen atom, a cyanide or an alkyl group having 1-4 carbon atoms andR.sub.1 is a hydrogen or halogen atom, nitro, alkyl, alkoxy, aryl, aryloxy, acyl or alkoxycarbonyl group,are prepared by esterifying two adjacent OH groups to give the cyclic carbonate, esterifying the free OH group with (meth)acrylic acid and selectively hydrolyzing the carbonate. The compounds are free of polyunsaturated impurities and can be used for preparing purely linear polymers.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: April 19, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Juergen Sander, Arnold Schneller
  • Patent number: 4737313
    Abstract: Novel ferroelectric liquid crystals exhibiting a chiral smectic C phase and liquid crystal compositions containing the same are provided, which liquid crystals are substituted biphenyl esters expressed by the general formula ##STR1## wherein R.sub.1 * represents an optically active alkyl group of 4 to 18 carbon atoms; ##STR2## represents ##STR3## or ##STR4## Z represents R.sub.2, R.sub.2 CO or R.sub.2 COO wherein R.sub.2 represents an alkyl group or an alkoxy group each of 1 to 18 carbon atoms; and X and Y each represent hydrogen atom (H), bromine atom (Br), chlorine atom (Cl), fluorine atom (F) or cyano group (CN), and either one of X or Y is always hydrogen atom.
    Type: Grant
    Filed: August 8, 1986
    Date of Patent: April 12, 1988
    Assignee: Chisso Corporation
    Inventors: Shinichi Saito, Hiromichi Inoue, Kanetsugu Terashima, Takashi Inukai, Kenji Furukawa
  • Patent number: 4728458
    Abstract: Polyphenyl-based liquid crystal compounds represented by the following general formula (1) and liquid crystal composition containing the same: ##STR1## wherein R.sup.1 represents a straight or branched C.sub.1-18 alkyl group, haloalkyl group, aralkyl group or haloaralkyl group with or without optically active carbon, R.sup.2 represents a straight or branched C.sub.1-6 alkyl group, haloalkyl group or aralkyl group with or without optically active carbon, W represents (1) --OCO-- or --COO--, in which case T represents a halogen atom or a methyl group, or (2) a single bond, --O-- or --OCOO--, in which case T represents a halogen atom, X represents --OCO--, --COO--, --C.tbd.C--, --CH.dbd.N--, --N.dbd.CH, Y represents single bond, --O--, --COO--, --OCO--, --CH.sub.2 --, --OCH.sub.2 --, --COOCH.sub.2 -- or --OCOCH.sub.2 --, Z.sub.1 and Z.sub.2 represent a hydrogen or halogen atom, a cyano group or nitro group, Z.sub.1 may be the same or different from Z.sub.
    Type: Grant
    Filed: February 10, 1986
    Date of Patent: March 1, 1988
    Assignee: Ajinomoto Co., Ltd.
    Inventors: Ryoichi Higuchi, Takao Sakurai, Tatsuru Tabohashi, Naoko Mikami, Kiriko Akaiwa, Eri Yamamoto, Koji Takeuchi
  • Patent number: 4713474
    Abstract: An alkanedicarboxylic diester compound represented by the formula: ##STR1## wherein n is an integer of 0-8 and R is a benzyl group. The compounds have a repellency action to vermin and a plasticization action to thermoplastic polymers, and are useful as a pesticide or plasticizer.
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: December 15, 1987
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Hiroyuki Akashi, Takeshi Inoue, Shoichi Horie
  • Patent number: 4713472
    Abstract: The preparation of 4,4'-dimethylstilbenedicarboxylate by acetylating 4,4'-bis(methoxycarbonyl)benzoin to give 4,4'-bis(methoxycarbonyl)benzoin acetate, selectively reducing 4,4'-bis(methoxycarbonyl)benzoin acetate with hydrogen to give 1,2-bis(4-methoxycarbonylphenyl)ethanol, and subjecting the 1,2-bis(4-methoxycarbonylphenyl)ethanol to either (1) dehydration or (2) acetylation to 1,2-bis(4-carbomethoxyphenyl)-1-acetoxy ethane followed by pyrolysis thereof to give the 4,4'-dimethylstilbenedicarboxylate. In this process, the new compounds 4,4'-bis(methoxycarbonyl)benzoin acetate, 1,2-bis(4-methoxycarbonylphenyl)ethanol, and 1,2-bis(4-carbomethoxyphenyl)-1-acetoxy ethane are produced and the novel preparations thereof are performed.
    Type: Grant
    Filed: May 15, 1986
    Date of Patent: December 15, 1987
    Assignee: Eastman Kodak Company
    Inventor: Dale E. Van Sickle
  • Patent number: 4710585
    Abstract: A liquid crystal compound represented by the following general formula:R*O--A--R or R*COO--A--Rwherein R* stands for an alkyl group having an asymmetric carbon atom, R stands for a linear alkyl group, and A stands for ##STR1##
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: December 1, 1987
    Assignees: Seiko Instruments & Electronics Ltd., Teikoku Chemical Industry Co., Ltd.
    Inventors: Masaaki Taguchi, Hitoshi Suenaga
  • Patent number: 4709079
    Abstract: Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicyclic acid, anthranilic acid and derivatives thereof.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: November 24, 1987
    Assignee: Eisai Co., Ltd.
    Inventors: Isao Yamatsu, Shinya Abe, Yuichi Inai, Takeshi Suzuki, Kensaku Kinoshita, Mannen Mishima, Yoshinori Katoh, Seiichi Kobayashi, Manabu Murakami, Kouzi Yamada
  • Patent number: 4686289
    Abstract: New anisotropic compounds with a cross-polarizing substituent have the formula (1) ##STR1## The increase in .epsilon..perp. is achieved by the polarizing group X, preferably the cyano group or a halogen atom, which is not laterally on the ring, as with the known compounds, but is on the bridge, that is to say is part of the main bridge bonding rings A and B to one another. Ring A has the formula (1a) or (1b) given herein and is always cycloaliphatic, while ring B can be identical to ring A or is an aromatic ring of the formula (1c) or (1d) herein. R.sup.1 and R.sup.2 are identical or different end groups of the formula (1e) herein.The radical X on the bridge causes less widening of the molecule than a radical X on a ring, which provides comparatively higher clear points and moreover enables aromatic rings to be omitted from the anisotropic compounds.
    Type: Grant
    Filed: February 25, 1986
    Date of Patent: August 11, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Tuong Huynh-Ba, Maged A. Osman
  • Patent number: 4686235
    Abstract: Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: August 11, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Michael N. Chang, Norman P. Jensen, Milton L. Hammond, Robert A. Zambias, John McDonald, Kathleen M. Rupprecht
  • Patent number: 4676604
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or straight-chain alkyl; R.sup.2 is --CN, --R, --COR, --COOR or when R.sup.2 is positioned on an aromatic ring R.sup.2 also can be --OR, --OOCR or --F; R is alkyl; A is a group with 1 to 4 six-membered rings, these rings being linked directly with one another and with ring B in each case via a single covalent bond or being linked at one or two positions also via --COO--, --OOC-- or --CH.sub.2 CH.sub.
    Type: Grant
    Filed: March 5, 1984
    Date of Patent: June 30, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Martin Petrzilka
  • Patent number: 4604485
    Abstract: Preparation of para-substituted 4-hydroxybenzophenones by forming poly(4-oxybenzoyl) in situ and reacting it with an appropriately substituted aromatic compound. The poly(4-oxybenzoyl) can be formed from a precursor such as 4-hydroxybenzoic acid by reaction with an agent which removes water from the acid to form the polymer. The reaction with the appropriately substituted aromatic compound, for example fluorobenzone, is effected in the presence of a Lewis acid compound such as aluminum chloride.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: August 5, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventor: Howard M. Colquhoun
  • Patent number: 4570006
    Abstract: Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsine, anti-plasmin, anti-kallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)R.sub.1 --COOH (II)with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: February 11, 1986
    Assignee: Torii & Co. Ltd.
    Inventors: Setsuro Fujii, Takashi Yaegashi, Toyoo Nakayama, Yojiro Sakurai, Shigeki Nunomura, Toshiyuki Okutome
  • Patent number: 4552926
    Abstract: The title compounds correspond to the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are alkyl, A is alkylene, X is --NH-- or --S--, m is 1 and n is 0 or 1, and are useful as stabilizers for organic polymers and lubricating oils to counteract the degradative effects of heat, light and air.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: November 12, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: John D. Spivack, Stephen D. Pastor
  • Patent number: 4546197
    Abstract: An analgesic and anti-inflammatory product comprising an acetyl salicylic derivative composition having the formula: ##STR1## wherein both R and R.sup.1 are hydrocarbon radicals and process for the manufacture thereof.
    Type: Grant
    Filed: March 24, 1983
    Date of Patent: October 8, 1985
    Assignee: R. P. Scherer Corporation
    Inventors: Neil E. Bateman, Ross A. Woods
  • Patent number: 4542230
    Abstract: A liquid crystal ester has a structure: ##STR1## where X and Y are fluorine or hydrogen at least one being hydrogen, and Z is either:(a) ##STR2## where R.sub.2 is alkyl, alkoxy, alkylcarbonyloxy or alkoxycarbonyloxy(b) ##STR3## where R.sub.3 is an alkyl group. The ester may be prepared by a conventional esterification from the corresponding phenol ##STR4## and the corresponding acid chloride Z--COCl. The ester may be used in mixtures with other liquid crystal compounds for use in known electro-optic devices.
    Type: Grant
    Filed: September 30, 1980
    Date of Patent: September 17, 1985
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: George W. Gray, David Lacey, Martin G. Pellatt, Bennett Sturgeon
  • Patent number: 4514416
    Abstract: Amidino compounds represented by the formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)R.sub.1 --COOH (II)with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: April 30, 1985
    Assignee: Torii & Co. Ltd.
    Inventors: Setsuro Fujii, Takashi Yaegashi, Toyoo Nakayama, Yojiro Sakurai, Shigeki Nunomura, Toshiyuki Okutome
  • Patent number: 4501912
    Abstract: A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula ##STR1## wherein R may be lower alkyl, lower hydroxyalkyl, lower alkynyl, aralkyl, or an ester-containing group and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.
    Type: Grant
    Filed: December 13, 1982
    Date of Patent: February 26, 1985
    Assignee: American Hospital Supply Corporation
    Inventors: William L. Matier, Sheung-Tsam Kam
  • Patent number: 4499298
    Abstract: A process is described for the preparation of aryl esters such as benzyl acetate by reacting an aryl alkyl compound such as toluene with a carboxylic acid such as acetic acid and oxygen in the presence of a catalytically effective amount of a catalyst comprising palladium metal, gold metal and a metal of Group VA of the Periodic Table of the Elements such as bismuth.
    Type: Grant
    Filed: December 20, 1979
    Date of Patent: February 12, 1985
    Assignee: National Distillers and Chemical Corporation
    Inventors: John A. Scheben, James A. Hinnenkamp
  • Patent number: 4452993
    Abstract: Novel heat-curable acrylic-terminated monomers are provided which exhibit an optically anisotropic melt phase at a temperature which enables it to undergo melt processing in the formation of molded articles, etc. The monomers are capable of being heat-cured at temperatures in excess of the melt processing temperatures to produce a thermoset self-reinforced composite. The monomer may, for example, consist essentially of the reaction product of p-acryloyloxybenzoic acid and a difunctional aromatic moiety in a molar ratio of about 2:1.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: June 5, 1984
    Assignee: Celanese Corporation
    Inventors: Anthony B. Conciatori, Eui W. Choe, Gerald Farrow
  • Patent number: 4442300
    Abstract: New bronchospasmolytically active compounds exhibiting long duration of action and reduced undesired side effects, of the structural formula ##STR1## and therapeutically acceptable salts thereof, in which formula R, R.sup.1 and R.sup.2 are as follows:R is selected from the group consisting of --C(CH.sub.3).sub.3, ##STR2## R.sup.1 is selected from the group consisting of H and R.sup.2 ; R.sup.2 is selected from the group consisting of ##STR3## in which formulas R.sup.3 is selected from the group consisting of (a) H; ##STR4## wherein R.sup.5 is a straight or branched alkyl group containing 1-4 carbon atoms;and ##STR5## and wherein R.sup.4 is selected from the group consisting of(a) H(b) an alkyl group containing 1-3 carbon atoms,process for the preparation thereof, chemical intermediates at their preparation, pharmaceutical compositions containing them and their medicinal use.
    Type: Grant
    Filed: July 1, 1981
    Date of Patent: April 10, 1984
    Assignee: Aktiebolaget Draco
    Inventors: O. A. Torsten Olsson, Leif .ANG. Svensson, Kjell I. L. Wetterlin
  • Patent number: 4433161
    Abstract: A novel family of diesters, methyl p-(.omega.-acetoxyalkoxy) benzoate wherein the alkoxy group has a chain length of 2 to 6, the method of preparation of the diesters, polymerization of the diesters and their use to form methyl p-(.omega.-hydroxy-n-alkoxy) benzoate.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: February 21, 1984
    Assignee: Ethicon, Inc.
    Inventors: Shalaby W. Shalaby, Edgar S. Schipper, Donald F. Koelmel
  • Patent number: 4402974
    Abstract: A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula ##STR1## wherein R may be lower alkyl, lower hydroxyalkyl, lower alkynyl, aralkyl, or an ester-containing group and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.
    Type: Grant
    Filed: June 23, 1981
    Date of Patent: September 6, 1983
    Assignee: American Hospital Supply Corporation
    Inventors: William L. Matier, Sheung-Tsam Kam
  • Patent number: 4399298
    Abstract: Novel fluorine-containing organic compounds having a positive dielectric anisotropy, useful as component(s) of liquid crystal compositions, and liquid crystal compositions containing the same are provided. The compounds have the general formula ##STR1## R.sub.1 and R.sub.3 both are 1-10 C alkyl or alkoxy; R.sub.2 is H or 1-10 C alkyl; and R.sub.4 is 1-10 C alkyl.
    Type: Grant
    Filed: February 12, 1981
    Date of Patent: August 16, 1983
    Assignee: Chisso Corporation
    Inventors: Shigeru Sugimori, Yukio Honda, Tetsuhiko Kojima
  • Patent number: 4390721
    Abstract: A novel 3-endo-protected hydroxyl-tricyclo[3,2,0,0.sup.2,7 ]heptan-6-one is described which can be alkylated stereospecifically to give a 5-endo-protected hydroxyl-bicyclo[2,2,1]heptan-2-one which may then be converted via a sequence of reactions into prostaglandins of the F-series having a protecting group at the 9-position. The synthesis of the tricyclo[3,2,0,0.sup.2,7 ]heptan-6-one is also described.
    Type: Grant
    Filed: November 1, 1978
    Date of Patent: June 28, 1983
    Assignee: Allen & Hanburys Limited
    Inventor: Stanley M. Roberts
  • Patent number: 4385070
    Abstract: Compounds of formula I wherein R.sup.1 and R.sup.2 are each selected from halomethyl and halo and R is nitro, cyano, lower alkoxycarbonyl, lower alkylcarbonyl, or di- or trifluoromethyl, and n has a value of zero to four, and compositions comprising them are useful as insecticides in agriculture, horticulture and other outlets. They may optionally be combined with other pesticides and/or synergists. The compounds may be prepared by conventional esterification processes from the corresponding acids and appropriately substituted benzyl alcohols or halides, some of which are novel.
    Type: Grant
    Filed: January 28, 1980
    Date of Patent: May 24, 1983
    Assignee: Imperial Chemical Industries Limited
    Inventors: Philip D. Bentley, Nazim Punja
  • Patent number: 4348410
    Abstract: A compound of the formula: ##STR1## wherein R.sub.1 represents a vanilyl, napthyl, pyridyl or .alpha.-tocopheryl group, or a group of the formula, ##STR2## wherein R.sub.2 represents a hydrogen atom, a lower alkoxy, formyl, lower alkanoyl or phenyl group, or a group of the formula --(CH.sub.2).sub.n COOR.sub.3, wherein R.sub.3 represents a hydrogen atom, a lower alkyl, phenyl, benzyl, anisyl or lower alkoxycarbonylmethyl group, and n represents an integer of 0 to 2, or a pharmaceutically acceptable salt thereof is effective for use as an anti-ulcer agent.
    Type: Grant
    Filed: September 15, 1980
    Date of Patent: September 7, 1982
    Assignees: Nippon Chemiphar Co., Ltd., Teikoku Chemical Industry Co., Ltd.
    Inventors: Mutsumi Muramatsu, Toshio Satoh, Yukio Yanagimoto, Tadami Shinuchi, Toshio Nakajima, Isao Nakajima
  • Patent number: 4336400
    Abstract: Mono-, di- and tri-esters of 3-(hydroxy or hydroxymethyl)-4-hydroxy-alpha-(aminomethyl)benzyl alcohols, obtained by methods involving reduction of the corresponding mono- and di-ester ketones, are useful for producing sympathomimetic effects, such as bronchodilation, of long duration with low cardiovascular stimulating effect, in warm-blooded mammals.
    Type: Grant
    Filed: August 30, 1978
    Date of Patent: June 22, 1982
    Assignee: Sterling Drug Inc.
    Inventors: Hiroaki Minatoya, Benjamin F. Tullar, Walter D. Conway
  • Patent number: 4317917
    Abstract: The invention relates to methyl- or methoxy-substituted 2-cynnamoyloxy-benzoic acids or to cynnamylesters of methyl- or methoxy-substituted 2-hydroxybenzoic acids, endowed with an interesting antiinflammatory, analgesic and antibacterial activity; and to a process for preparing said compounds.
    Type: Grant
    Filed: March 21, 1980
    Date of Patent: March 2, 1982
    Assignee: Ausonia Farmaceutici S.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4310465
    Abstract: A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: January 12, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gary L. Olson, Gabriel Saucy
  • Patent number: 4299844
    Abstract: Anti-inflammatory naphthyl compounds, their preparation and pharmaceutical compositions containing the same. The anti-inflammatory activity has a wide spectrum coupled with low side effects such as gastrointestinal irritancy or oestrongenicity. The compounds possess a chiral center at C-2 and can exist as mixtures of optical isomers or as substantially pure optical isomers.
    Type: Grant
    Filed: July 9, 1979
    Date of Patent: November 10, 1981
    Assignee: Beecham Group Limited
    Inventor: Alexander C. Goudie
  • Patent number: 4285971
    Abstract: Halogenated phenol esters of the formula ##STR1## wherein X represents chlorine or fluorine and R represents hydrogen, alkyl of 1 to 22 carbon atoms, alkenyl of 2 to 22 carbon atoms, benzyl which is unsubstituted or substituted by chlorine or bromine atoms, or phenyl which is unsubstituted or substituted by alkyl or alkoxy, each of 1 to 4 carbon atoms, carboxyl, chlorine and/or bromine. The invention also relates to a method of protecting organic and inorganic material from attack by microorganisms, in particular of providing textiles with an antimicrobial and rotproof finish, of protecting wood from rot, and of preventing the formation of slime in the manufacture of paper.
    Type: Grant
    Filed: July 30, 1979
    Date of Patent: August 25, 1981
    Assignee: Ciba-Geigy Corporation
    Inventor: Rene Muntwyler
  • Patent number: 4276430
    Abstract: Dihydroxybenzoic acid derivatives and compositions containing same are useful for topical application to the skin as well as for systemic administration. The compounds are especially effective for providing an analgesic, anti-pyretic, and anti-inflammatory effect.
    Type: Grant
    Filed: July 26, 1979
    Date of Patent: June 30, 1981
    Assignee: The Procter & Gamble Company
    Inventors: Herbert H. Reller, Herbert C. Kretschmar
  • Patent number: 4267360
    Abstract: Derivatives of hexafluoropropene dimer expressed by the following general formula ##STR1## in which R.sub.f represents (CF.sub.3).sub.2 C.dbd.C(CF.sub.2 CF.sub.3) or (CF.sub.3).sub.2 CH--CF(CF.sub.2 CF.sub.3) and R represents a hydrocarbon residue of a carboxylic acid having one free site capable of reacting with the dimer. A process for preparing the derivatives is also disclosed in which the dimer is contacted with the carboxylic acid in an inert solvent in the presence of a catalyst. Metal, amine or ammonium salts of the acid may be also used for the reaction, in which case the reaction is feasible in the absence of a catalyst.
    Type: Grant
    Filed: October 15, 1979
    Date of Patent: May 12, 1981
    Assignee: Central Glass Company, Limited
    Inventors: Masahiro Ozawa, Tadaaki Komatsu, Kimiaki Matsuoka
  • Patent number: 4259332
    Abstract: Novel taurine derivatives of general formula (I) ##STR1## (wherein R.sup.1 is nicotinoyl, 3,4,5-trimethoxybenzoyl or acetylsalicyloyl and R.sup.2 is as defined for R.sup.1 or is --CH.sub.2 CH.sub.2 OR.sup.1) have antilipemic and choleretic activities. The compound in which R.sup.2 .dbd.--CH.sub.2 CH.sub.2 OR.sup.1 and R.sup.1 is acetylsalicyloyl exhibits high antiinflammatory, analgesic and antipyretic activity and is essentially free of the unfavorable effect of acetylsalicylic acid on the stomach.
    Type: Grant
    Filed: February 11, 1980
    Date of Patent: March 31, 1981
    Assignee: Laboratorio Chimico Farmaceutico CAUSYTH S.p.A.
    Inventors: Raffaele Passoni, Vittorio Camboni
  • Patent number: 4218555
    Abstract: Acetylene end-capped polyimide oligomers are prepared by a process including the following sequential steps:1. Preparing an alkanol or ether solution containing substantially 1 molar equivalent of a dialkyl ester of an aromatic tetracarboxylic acid,2. Adding substantially 0.5 to 0.8 molar equivalent of an aromatic diamine to the solution of (1) to form a reaction product between the diacid and the diamine,3. Adding an aminoarylacetylene to the solution of (2) in a quantity sufficient to provide amine groups equivalent to the free carboxylic acid groups present in the product of (2).4. Heating the solution of (3) to vaporize the solvent therefrom, and5. Heating the product of (4) to convert the carboxylic acid groups, the ester groups, and the amino groups thereof to imide groups.The temperature in steps (2) and (3) is maintained below about 50.degree. C. The temperature in steps (4) and (5) is maintained below about 210.degree. C.
    Type: Grant
    Filed: November 1, 1978
    Date of Patent: August 19, 1980
    Assignee: Gulf Oil Corporation
    Inventors: Patricia A. Antonoplos, Clarence D. Bertino, William J. Heilman
  • Patent number: 4206106
    Abstract: The products of the invention are vinyl end-capped oligomers which are prepared from 2,4-bis (p-aminobenzyl) aniline and a vinyl substituted aromatic monoamine, the principal component of which is the compound whose structure is shown in FIG. 3. The products are prepared from either of two (2) precursors. The first precursor is a compound whose structure is shown in FIG. 2 and which is prepared from 2,4-bis (p-aminobenzyl) aniline, a dianhydride of an aromatic tetracarboxylic acid such as 3,3'4,4'-benzophenonetetracarboxylic acid (BTDA) and a vinyl substituted aromatic monoamine, such as 3-aminophenyl-ethylene (APE). The second precursor is a complex amine salt having the structure shown in FIG. 6 and which is prepared from 2,4-bis-(p-aminobenzyl) aniline, a dialkyl ester of BTDA and APE.
    Type: Grant
    Filed: April 5, 1979
    Date of Patent: June 3, 1980
    Assignee: Gulf Oil Corporation
    Inventors: William J. Heilman, Daniel J. Hurley
  • Patent number: 4206107
    Abstract: The products of the invention are acetylene end-capped polyimide oligomers prepared from a dianhydride of an aromatic tetracarboxylic such as 3, 3', 4, 4'-benzophenonetetracarboxylic acid, an aromatic triamine, and a propargyl ester of an amino-substituted aromatic acid such as aminobenzoic acid. The structure of the polyimide oligomers is shown in FIG. 3.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: June 3, 1980
    Assignee: Gulf Oil Corporation
    Inventors: Wai Y. Chow, S. Paul Thackaberry
  • Patent number: 4200580
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is a straight chain alkyl group of 1 to 10 carbon atoms and R.sub.2 is an alkyl, alkoxy, acyloxy, alkyl carbonato group having 1 to 10 carbon atoms, CN or NO.sub.2. The dioxanylphenyl benzoate compounds of the invention are useful as liquid crystal materials in electro-optical displays.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: April 29, 1980
    Assignee: Timex Corporation
    Inventor: Ying Y. Hsu
  • Patent number: 4195916
    Abstract: Novel liquid crystal compounds are disclosed, which are chiral esters based upon the phenol ##STR1## Typical examples are: ##STR2## and mixtures of these compounds have a helical pitch such that the mixtures reflect light of a specific wavelength when illuminated with ordinary light and the pitch is temperature sensitive so that the mixtures can be used in temperature indicating devices. Specific examples are given as are samples of mixtures that can be used in phase change electro-optic display devices.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: April 1, 1980
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: David Coates, George W. Gray, Damien G. McDonnell
  • Patent number: RE30922
    Abstract: The products of the invention are vinyl end-capped oligomers which are prepared from 2,4-bis (p-aminobenzyl) aniline and a vinyl substituted aromatic monoamine, the principal component of which is the compound whose structure is shown in FIG. 3. The products are prepared from either of two (2) precursors. The first precursor is a compound whose structure is shown in FIG. 2 and which is prepared from 2,4-bis (p-aminobenzyl) aniline, a dianhydride of an aromatic tetracarboxylic acid such as 3,3'4,4'-benzophenonetetracarboxylic acid (BTDA) and a vinyl substituted aromatic monoamine, such as 3-aminophenyl-ethylene (APE). The second precursor is a complex amine salt having the structure shown in FIG. 6 and which is prepared from 2,4-bis-(p-aminobenzyl) aniline, a dialkyl ester of BTDA and APE.
    Type: Grant
    Filed: August 25, 1980
    Date of Patent: May 4, 1982
    Assignee: Gulf Oil Corporation
    Inventors: William J. Heilman, Daniel J. Hurley
  • Patent number: RE31715
    Abstract: Novel liquid crystal compounds are disclosed, which are chiral esters based upon the phenol ##STR1## Typical examples are: ##STR2## and mixtures of these compounds have a helical pitch such that the mixtures reflect light of a specific wavelength when illuminated with ordinary light and the pitch is temperature sensitive so that the mixtures can be used in temperature indicating devices. Specific examples are given as are samples of mixtures that can be used in phase change electro-optic display devices.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: October 30, 1984
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: David Coates, George W. Gray, Damien G. McDonnell