Polycarboxylic Acids Or Salts Thereof Patents (Class 562/480)
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Patent number: 7358391Abstract: Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.Type: GrantFiled: November 28, 2006Date of Patent: April 15, 2008Assignee: E.I. du Pont de Nemours and CompanyInventor: Joachim C. Ritter
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Patent number: 7355070Abstract: 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.Type: GrantFiled: November 28, 2006Date of Patent: April 8, 2008Assignee: E. I. du Pont de Nemours and CompanyInventor: Joachim C. Ritter
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Patent number: 7348452Abstract: A method for liquid phase oxidation of p-xylene with molecular oxygen to terephthalic acid that minimizes solvent loss through solvent burn and minimizes the formation of incomplete oxidation products such as 4-carboxybenzaldehyde (4-CBA). P-xylene is oxidized at a temperature in the range of 120° C. to 250° C. and in the presence of a source of molecular oxygen and a catalyst composition substantially free of zirconium atoms comprising a source of nickel (Ni) atoms, a source of manganese (Mn) atoms, and a source of bromine (Br) atoms, to form a crude reaction mixture comprising terephthalic acid and incompletely oxidized reaction products comprising 4-CBA, wherein the stoichiometric molar ratio of bromine atoms to manganese atoms is 1.5 or less, and the amount of nickel atoms is at least 500 ppm.Type: GrantFiled: April 22, 2004Date of Patent: March 25, 2008Assignee: Eastman Chemical CompanyInventor: Gino Georges Lavoie
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Patent number: 7169955Abstract: Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants: wherein X1 is H, halogen, formyl, optionally halogenated (C1–C6) alkyl, (C1–C6) alkylthio, or the like; X2 is H, halogen, formyl, hydroxyl, (C1–C6) alkyl, —C(?O)—R1 (wherein R1 is H, halogen, hydroxyl, (C1–C6) alkyl, or NR2R3, with R2 and R3 being each H, C1-6 alkyl, or the like), or the like; X3 is H, halogen, hydroxyl, cyano, isocyanate, hydrazino, diazo, —C(?O)—R1, —SO2—R4 (wherein R4 is halogen, hydroxyl, (C1–C6) alkyl, or NR5R6, with R5 and R6 being each H or (C1–C6) alkyl), or the like; and X4 is H, halogen, (C1–C6) alkyl, or (C1–C6) alkoxy, with publicly known compounds being excepted.Type: GrantFiled: October 22, 2004Date of Patent: January 30, 2007Assignee: Nihon Nohyaku Co., Ltd.Inventors: Masanobu Onishi, Kenichi Ikeda, Takashi Shimaoka, Masanori Yoshida
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Patent number: 7115541Abstract: A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.Type: GrantFiled: November 8, 2001Date of Patent: October 3, 2006Assignee: Daicel Chemical Industries, Ltd.Inventors: Yasutaka Ishii, Tatsuya Nakano, Takahiro Iwahama, Naruhisa Hirai
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Patent number: 7019165Abstract: An active and selective hydrocarbon partial oxidation catalyst comprises an activated partially-reduced polyoxometallate, preferably niobium polyoxomolybdate, that is prepared from a suitable polyoxoanion, which has been exchanged with a suitable cation and activated by heating to an activation effective temperature in the presence of a suitable reducing agent such as pyridinium. C3 and C4 hydrocarbons may be partially oxidized selectively to acrylic acid and maleic acid.Type: GrantFiled: April 11, 2005Date of Patent: March 28, 2006Assignee: California Institute of TechnologyInventors: Mark E. Davis, Christopher J. Dillon, Joseph H. Holles, Jay A. Labinger, Axel Brait
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Patent number: 6867322Abstract: An ester-forming monomer obtained by depolymerization of polytrimethylene terephthalate and having an acrolein content of no greater than 0.5 wt %. Polymers obtained using the monomer and fibers, films and molded articles comprising the polymers. The ester-forming monomer is obtained by reacting polytrimethylene terephthalate with at least one compound selected from among monoalcohols, 1,3-propanediol and water in the presence of a basic substance. When the recovered ester-forming monomer is used as the starting material for production of a polymer, it is possible to produce a molding polymer for fibers, films and the like with quality equivalent to or higher than that obtained using virgin monomer.Type: GrantFiled: September 13, 2000Date of Patent: March 15, 2005Assignee: Asahi Kasei Kabushiki KaishaInventors: Jinichiro Kato, Katsuhiro Fujimoto
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Patent number: 6855845Abstract: The present invention relates to a process for preparing bromoisophthalic acid compounds, particularly 5-bromoisophthalic acid compounds and 4,5-dibromoisophthalic acid compounds comprising brominating an isophthalic acid compound of the general formula (1) wherein R1 and R2 independently of one another are hydrogen atom or C1-6 alkyl, with bromine in a solvent containing sulfur trioxide. The object of the invention is to provide a process for preparing bromoisophthalic acid compounds, particularly 5-bromoisophthalic acid compounds and 4,5-dibromoisophthalic acid compounds in a highly selective manner by using bromine that is industrially inexpensive.Type: GrantFiled: May 30, 2001Date of Patent: February 15, 2005Assignee: Nissan Chemical Industries, Ltd.Inventors: Masaki Nagai, Hideo Suzuki, Isao Hashiba
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Publication number: 20040176625Abstract: This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vitro and in vivo applications.Type: ApplicationFiled: March 3, 2004Publication date: September 9, 2004Applicant: The Regents of the University of CaliforniaInventors: Lawrence S.B. Goldstein, David John Faulkner, Roman Sakowicz, Michael S. Berdelis, Christine L. Blackburn, Cordula Hopmann
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Patent number: 6765113Abstract: A process for the production of an aromatic carboxylic acid comprising contacting in the presence of a catalyst, within a continuous flow reactor, one or more precursors of the aromatic carboxylic acid with an oxidant, such contact being effected with said precursor(s) and the oxidant in an aqueous solvent comprising water under supercritical conditions or near supercritical conditions close to the supercritical point such that said one or more precursors, oxidant and aqueous solvent constitute a substantially single homogeneous phase in the reaction zone, wherein the contact of at least part of said precursor with said oxidant is contemporaneous with contact of said catalyst with at least part of said oxidant.Type: GrantFiled: July 13, 2001Date of Patent: July 20, 2004Assignee: E.I. Du Pont de Nemours and CompanyInventors: Derek Alexander Graham, Paul Anthony Hamley, Raymond Oliver, Martyn Poliakoff, Duncan Woodcock, Thomas Ilkenhans
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Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents
Publication number: 20040127744Abstract: A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.Type: ApplicationFiled: January 30, 2003Publication date: July 1, 2004Inventors: James Lupton Hedrick, Pinar Kilickiran, Gregory Walker Nyce, Robert M. Waymouth -
Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents
Publication number: 20040127720Abstract: A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.Type: ApplicationFiled: December 26, 2002Publication date: July 1, 2004Inventors: James Lupton Hedrick, Pinar Kilickiran, Gregory Walker Nyce, Robert M. Waymouth -
Patent number: 6723873Abstract: A process for forming reactants useful in the manufacture of polyethylene terephthalate includes the steps of: (a) contacting recyclable polyethylene terephthalate with ammonium hydroxide whereby a mixture of ammonium terephthalate and ethylene glycol is formed, (b) separating the ammonium terephthalate, and (c) heating said ammonium terephthalate at a temperature from about 225° C. to about 300° C. to produce terephthalic acid.Type: GrantFiled: August 30, 2000Date of Patent: April 20, 2004Assignee: Eastman Chemical CompanyInventor: William Speight Murdoch
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Patent number: 6720448Abstract: The present invention relates to a method of recovering a solution comprising the chemical species obtained by depolymerization of PET from a material containing poly(ethylene terephthalate) in the form of bottles, by making said material react, in the absence of water, with a reagent consisting of one or more metal salts of a weaker acid than the terephthalic acid and of ethylene glycol, until a water-soluble intermediate product is obtained, and subsequently carrying out dissolution in water, stirring and filtering.Type: GrantFiled: October 2, 2001Date of Patent: April 13, 2004Inventor: Massimo Broccatelli
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Publication number: 20040058346Abstract: The present invention provides a polynucleotide cleavage agent switched on by photo-irradiation and a method of cleaving or decomposing a polynucleotide such as DNA or RNA using this agent switched on in this manner. More specifically, said polynucleotide cleavage agent switched on by photo-irradiation comprises cyclopropane or a 2,2-dihalogeno-cyclopropane ring between “A” unit and “B” unit, wherein said “A” unit is an aromatic group having an electron withdrawing property and is excited by photo-irradiation, and said “B” unit is a hydrophilic functional group. Said polynucleotide cleavage agent may further contain “C” unit which can recognize DNA sequences, and also a spacer molecule, if desired.Type: ApplicationFiled: March 5, 2003Publication date: March 25, 2004Applicant: TOTTORI UNIVERSITYInventors: Toshiyuki Itoh, Keiko Ninomiya, Masahiko Shishido
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Patent number: 6703422Abstract: The present invention relates to novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: GrantFiled: October 11, 2001Date of Patent: March 9, 2004Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 6689898Abstract: This invention relates to novel compounds of the formula: wherein R1 is H or C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; R2 and R3 are each independently C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; X is Cl, Br or I; or stereoisomers thereof.Type: GrantFiled: March 22, 2002Date of Patent: February 10, 2004Assignee: Aventis Pharmaceuticals Inc.Inventor: Timothy A. Ayers
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Patent number: 6683208Abstract: New optically active bis[1-phospha-2,3-diphenyl-4,5-dimethylnorbornadiene] diphosphines and new optically active transition metal complexes with said phosphines are described. The complexes are useful as catalysts to promote hydrogenation of substrates.Type: GrantFiled: February 19, 2002Date of Patent: January 27, 2004Assignee: Rhone-Poulenc ChimieInventors: Francois Mathey, Frédéric Robin, Francois Mercier, Michel Spagnol
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Patent number: 6670503Abstract: The present invention relates to a method of recovering terephthalic acid from a material containing poly(ethylene terephthalate) (P.E.T.) in the form of bottles, by making said material react, in the absence of water, with a reagent consisting of one or more metal salts of a weaker acid than the terephthalic acid, until a water-soluble compound is obtained, and subsequently carrying out dissolution in water and acidification.Type: GrantFiled: February 21, 2001Date of Patent: December 30, 2003Inventor: Massimo Broccatelli
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Patent number: 6657077Abstract: The invention concerns a method for producing terephthalate of alkaline metal and alkylene glycol from recuperated alkylene polyterephthalate. It comprises saponification of said alkylene terephthalates with an aqueous sodium solution, adding a sufficient volume of water to ensure solubilization of the entire alkaline metal terephthalate produced in the reaction medium liquid phase and crystallisation of the sodium terephthalate by concentration of said liquid phase. The resulting sodium terephthalate can be directly used for producing pure terephthalic acid usable for the renewed production of alkylene polyterephthalates to be used in the food industry.Type: GrantFiled: November 16, 2000Date of Patent: December 2, 2003Assignee: TrediInventors: Jacques Thauront, Laurent Bonnamich, Guy Fraysse
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Patent number: 6620954Abstract: Disclosed are novel phosphinometallocenylamides that are useful as ligands for asymmetric catalysis. The novel ligands, which are readily modifiable, contain both a phosphine and an amide functionality linked by a metallocene backbone. In addition, the novel compounds are phosphine-amides derived from a phosphine-amine, rather than a phosphine-carboxylic acid. Further, described herein are both processes to make the novel ligands as well as processes that employ such ligands in a catalytically active composition comprising one or more phosphinometallocenylamide compounds in complex association with one or more Group VIb or Group VIII metals to provide chiral products. Further, we describe exemplary catalyst complexes incorporating the novel ligands.Type: GrantFiled: March 25, 2002Date of Patent: September 16, 2003Assignee: Eastman Chemical CompanyInventor: Neil Warren Boaz
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Patent number: 6617414Abstract: The present invention provides aromatic diamine/aromatic dicarboxylate having the following formula (I) NH2—Ar1—NH2.HOOC—Ar2—COOH (I) wherein each symbol is as defined in the specification, which is in the form of particles having a median diameter of 5-100 &mgr;m and whiteness of not less than 75. This salt has high polymerizability and preferably has superior storage stability. Therefore, it can be preferably used for the production of polybenzazole that can be formed into a fiber and a film having high strength, high elastic modulus and high heat resistance.Type: GrantFiled: December 15, 2000Date of Patent: September 9, 2003Assignee: Toyo Boseki Kabushiki KaishaInventors: Kiyoshi Hotta, Fuyuhiko Kubota
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Patent number: 6610875Abstract: The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2 independently represent a saturated or aromatic carbocyclic group, optionally substituted.Type: GrantFiled: December 11, 2001Date of Patent: August 26, 2003Assignees: Rhodia Chimie, Centre National de la Recherche Scientifique (CNRS)Inventors: Marc Lemaire, Rob Tel Halle, Emmanuelle Schulz, Michel Spagnol
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Publication number: 20030105088Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.Type: ApplicationFiled: January 17, 2002Publication date: June 5, 2003Applicant: GUILFORD PHARMACEUTICALS INC.Inventors: Takashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
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Patent number: 6566548Abstract: Novel molecular compounds containing carboxylic acid derivatives represented by general formula (I) or (II) as the constituent compound and exhibiting excellent performances in various technical fields including selective separation of useful substances, chemical stabilization, nonvolatilization, prolongation of release and powderization, wherein X is (CH2)n or p-phenylene; n is 0, 1, 2 or 3; R1 to R8 and R13 to R20 are each hydrogen, C1-C6 alkyl, C2-C4 alkenyl, phenyl optionally substituted with C1-C6 alkyl, halogeno or C1-C6 alkoxy; and R9 to R12 and R21 to R24 are each hydrogen, C1-C6 alkyl, C2-C4 alkenyl, C11-C12 aralkyl or an alkali metal.Type: GrantFiled: March 29, 2001Date of Patent: May 20, 2003Assignee: Nippon Soda Co., Ltd.Inventors: Satoru Abe, Hiroshi Suzuki
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Patent number: 6562998Abstract: Granular product of 2-hydroxynaphthalene-3-carboxylic acid with well-suppressed dusting tendency, and process for preparing the same is provided. Granular product of 2-hydroxynaphthalene-3-carboxylic acid having an average particle size of 150 &mgr;m or more and a hardness of 70-3000 g, and a process for preparing the same comprising the steps of dry compressing powdery 2-hydroxynaphthalene-3-carboxylic acid to give compressed material and pulverizing and classifying the same.Type: GrantFiled: June 26, 2001Date of Patent: May 13, 2003Assignee: Kabushiki Kaisha Ueno Seiyako Oyo KenkyujoInventors: Ryuzo Ueno, Masaya Kitayama, Nobutaka Izumichi, Syungo Nara, Masaharu Kittaka
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Patent number: 6562996Abstract: A composition containing isomeric mixtures of arylaldehydes prepared from a mixed alkyl aromatic feedstock. A composition containing isomeric mixtures of dimethylbenzaldehydes prepared from a mixed xylene feedstock using a Gatterman-Koch type reaction. A composition of isomeric mixtures of tolualdehydes prepared from a toluene feedstock using a Gatterman-Koch type reaction.Type: GrantFiled: August 20, 2001Date of Patent: May 13, 2003Assignee: ExxonMobil Chemical Patents Inc.Inventor: Ramzi Yanni Saleh
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Patent number: 6562999Abstract: Disclosed is a process for purifying 2,6-naphthalene dicarboxylic acid produced by disproportionation and more efficiently recycling byproduct dipotassium salts which includes the steps of: a) Contacting an aqueous solution containing the disalt of 2,6-NDA(2,6-K2NDA) with carbon dioxide to form as a precipitate the monopotassium salt of 2,6-NDA (KHNDA) and an aqueous solution containing 2,3-KHNDA, K2NDA, and potassium bicarbonate; b) Disproportionating said monopotassium salt (KHNDA) to form 2,6-NDA and an aqueous solution containing K2NDA, and potassium bicarbonate; c) Separating said 2,6-NDA and concentrating said aqueous solution containing K2NDA and potassium bicarbonate by reverse osmosis.Type: GrantFiled: January 9, 2002Date of Patent: May 13, 2003Assignee: Mossi & Ghisolfi Overseas S.A.Inventors: Zaida Diaz, John B. Rodden
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Patent number: 6521786Abstract: A description is given here of a novel process for the production of monocarboxylic and polycarboxylic aromatic acids by the catalytic oxidation in homogeneous phase of aromatic compounds carrying at least one oxidizable substituent group attached directly to the carbon atom of the corresponding aromatic nucleus. The novel process according to the present invention comprises the steps of: a) catalytically oxidizing the corresponding aromatic precursors in liquid phase in the presence of gaseous oxygen; b) filtering the end product; c) recycling into the oxidation reactor at least part of the mother liquors resulting from the filtration stage, and is characterized by the fact that said steps from (a) to (c) are carried out in a closed and continuous cycle operating substantially under the same pressure and temperature conditions, preferably at 2-10 barg and 100-140° C.Type: GrantFiled: August 8, 2001Date of Patent: February 18, 2003Inventors: Franco Codignola, Antonio Moro
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Publication number: 20020068841Abstract: A composition containing isomeric mixtures of arylaldehydes prepared from a mixed alkyl aromatic feedstock. A composition containing isomeric mixtures of dimethylbenzaldehydes prepared from a mixed xylene feedstock using a Gatterman-Koch type reaction. A composition of isomeric mixtures of tolualdehydes prepared from a toluene feedstock using a Gatterman-Koch type reaction.Type: ApplicationFiled: August 20, 2001Publication date: June 6, 2002Inventor: Ramzi Yanni Saleh
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Patent number: 6388123Abstract: The present invention relates to novel compounds of the formula (I) in which Het represents one of the groups in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, and to their use as pesticides and herbicides.Type: GrantFiled: June 1, 2001Date of Patent: May 14, 2002Assignee: Bayer AktiengesellschaftInventors: Volker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Alan Graff, Udo Schneider
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Patent number: 6362365Abstract: The present invention relates to a process for preparing trifluorobenzoic acids of the formula in which R is a straight-chain or branched alkyl radical having 1 to 6 C-atoms, an unsubstituted phenyl radical, a substituted phenyl radical which contains one or two alkyl or alkoxy groups having in each case 1 to 4 C atoms, or an araliphatic radical having 7 to 12 C atoms, which comprises reacting a compound of the formula in which R1 and R2 are identical or different and are —CN, —COOR3, where R3 is H, Li, Na, K, MgCl, MgBr, MgI, ½Mg, ½Ca or an alkyl radical having 1 to 6 C atoms, or —CONR4R5, where R4 and R5 are identical or different and are an alkyl radical having 1 to 6 C atoms, with at least one organometallic compound of the formula CuR, CuLiR2, MgXR, ZnR3, LiR, AlX2R, AlXR2AlR3 Al2Cl3R3, where R is as defined in formula (1) and X is Cl, Br or I, in the presence of an inert solvent at from −80 to +150° C.Type: GrantFiled: November 3, 1999Date of Patent: March 26, 2002Assignee: Clariant GmbHInventors: Andreas Maier, Ralf Pfirmann
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Patent number: 6320083Abstract: A process for the carbonylation of alkyl aromatic compounds uses acidic ionic liquids. In one embodiment, the ionic liquid is intrinsically acidic, having an anion mole fraction of greater than 0.5. The ionic liquids include those comprised of a quaternary nitrogen-containing cation and a metal halide anion. The process provides for good conversion and selectivity in the production of the corresponding aromatic aldehyde compound.Type: GrantFiled: September 10, 1999Date of Patent: November 20, 2001Assignee: ExxonMobil Chemical Co.Inventor: Ramzi Yanni Saleh
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Patent number: 6303827Abstract: Alkyl aromatic compounds are converted to alkyl aromatic aldehydes by a carbonylation reaction. The carbonylation catalyst can be a high boiling point carbonylation catalyst which allows for the separation of the aldehyde product by selective volatilization. Alternatively, the carbonylation catalyst can be selected from perfluoroalkyl sulfonic acids having 2 to 18 carbon atoms, perfluoroether sulfonic acids having 2 to 18 carbon atoms, BF3(ROH)x wherein R represents CH3 or H and X is a number within the range of from 0.2 to 2, GaBr3, GaCl3, TaF5, NbF5, and NbBr5, with the proviso that when the catalyst is TaF5, NbF5, or NbBr5, then the reaction takes place in the absence of added HF. Preferably, all of the carbonylation reactions take place in the absence of added HF. The alkyl aromatic aldehydes can be oxidized to form an aromatic acid.Type: GrantFiled: September 10, 1999Date of Patent: October 16, 2001Assignee: ExxonMobil Chemicals Patents Inc.Inventors: Ramzi Yanni Saleh, Christopher L. Becker, Robert C. Michaelson, Richard H. Schlosberg
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Publication number: 20010014756Abstract: The present invention provides aromatic diamine/aromatic dicarboxylate having the following formula (I)Type: ApplicationFiled: December 15, 2000Publication date: August 16, 2001Inventors: Kiyoshi Hotta, Fuyuhiko Kubota
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Publication number: 20010009923Abstract: Non-hygrocopic salts of L-carnitine and of the lower alkanoyl L-carnitines with pamoic acid are described, which are used to prepare solid compositions suitable for oral administration. Solid compositions containing such salts are also described.Type: ApplicationFiled: December 21, 2000Publication date: July 26, 2001Inventors: Mose Santaniello, Nazareno Scafetta, Maria Ornella Tinti
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Patent number: 6248879Abstract: A process for preparation of crosslinked cellulosic products containing at least 30 wt. % cellulosic fibers and the polyanhydride crosslinked cellulosic products resulting therefrom wherein a cellulosic material is treated with an aqueous solution of a polycarboxylic acid formed by hydrolysis of a polyanhydride of the structure which comprises the reaction product of trimellitic anhydride and a diol in the mole ratio of from about 2.0:0.9 to about 2.0:1.1, wherein R is selected from the group consisting of alkyl, alkylene and cycloalkylene moieties of up to 12 carbon atoms and ethylene oxide and propylene oxide moieties of molecular weight up to about 6000, wherein said cellulosic material is impregnated with an aqueous solution of said polyanhydride, dried, and heated to a temperature of from about 120° C. to about 200° C.Type: GrantFiled: August 13, 1999Date of Patent: June 19, 2001Assignee: BP Amoco CorporationInventors: Ronald L. Anderson, Wendell W. Cattron, Vincent F. Smith, Jr., David J. Fenoglio
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Patent number: 6143905Abstract: 1,7-Disubstituted perylene-3,4,9,10-tetracarboxylic dianhydrides I and perylene-3,4,9,10-tetracarboxylic acids Ia ##STR1## where R is substituted or unsubstituted aryloxy, arylthio, hetaryloxy or hetarylthio,their preparation and use as pigments, laser dyes and precursors for preparing fluorescent dyes, polymeric colorants, pigments and pigment additives, and 1,7-disubstituted perylene-3,4,9,10-tetracarboxylic diimides (VI) as intermediates thereof.Type: GrantFiled: June 18, 1998Date of Patent: November 7, 2000Assignee: BASF AktiengesellschaftInventors: Arno Bohm, Harald Arms, Georg Henning, Peter Blaschka
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Patent number: 6103919Abstract: A catalytic process for production of biphenyl and its derivatives by coupling of substituted or unsubstituted monoaryl compounds in the presence of a catalytic system comprising at least one Pd (II) compound and a strong acid or a mixture of acids. The process provides high conversions and high selectivity under mild temperature conditions and short reaction times. The strong acid or mixture of acids has a Hammett acidity of less than about -10, and contains a predominant amount of counterions which form a weak ligand complex with palladium (II). The method is highly selective to formation of desired biaryl isomers, such as 4,4'-isomers, and allows control of the relative amounts of isomers of biaryl compounds and substituted monoaryl compounds in the final product.Type: GrantFiled: July 7, 1998Date of Patent: August 15, 2000Assignee: Arteva North America S.A.R.L.Inventors: David Anthony Schiraldi, Sheldon Christopher Sherman, Dhiraj Sudesh Sood, Mark Gilmore White
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Patent number: 6037493Abstract: The present invention relates to optically active diphosphines. It is also targeted at their preparation according to a process for the resolution of the racemic mixture of the said phosphines to optically active isomers.The subject of the invention is new optically active bis[1-phospha-2,3-diphenyl-4,5-dimethylnorbornadiene] diphosphines and a process for resolving the racemic bis[1-phospha-2,3-diphenyl-4,5-dimethylnorbornadiene] mixture which comprises reacting it with a palladium or platinum complex as chiral auxiliary in an organic solvent, thus forming diastereoisomer complexes, and then resolving the said optically pure complexes.The invention also relates to new optically active metal complexes comprising the said phosphines and to their use in a process for the preparation of optically active carboxylic acids and/or derivatives according to a process for the hydrogenation of .alpha.,.beta.-unsaturated carboxylic acids and/or derivatives.Type: GrantFiled: February 17, 1998Date of Patent: March 14, 2000Assignee: Rhone-Poulenc ChimieInventors: Francois Mathey, Frederic Robin, Francois Mercier, Michel Spagnol
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Patent number: 6001877Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B.sub.4.Type: GrantFiled: May 20, 1998Date of Patent: December 14, 1999Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Mitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
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Patent number: 5981739Abstract: A process for preparation of crosslinked cellulosic products containing at least 30 wt. % cellulosic fibers and the polyanhydride crosslinked cellulosic products resulting therefrom wherein a cellulosic material is treated with an aqueous solution of a polycarboxylic acid formed by hydrolysis of a polyanhydride of the structure ##STR1## which comprises the reaction product of trimellitic anhydride and a diol in the mole ratio of from about 2.0:0.9 to about 2.0:1.1, wherein R is selected from the group consisting of alkyl, alkylene and cycloalkylene moieties of up to 12 carbon atoms and ethylene oxide and propylene oxide moieties of molecular weight up to about 6000, wherein said cellulosic material is impregnated with an aqueous solution of said polyanhydride, dried, and heated to a temperature of from about 120.degree. C. to about 200.degree. C.Type: GrantFiled: September 10, 1997Date of Patent: November 9, 1999Assignee: BP Amoco CorporationInventors: Ronald L. Anderson, Wendell W. Cattron, Vincent F. Smith, Jr., David J. Fenoglio
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Patent number: 5965741Abstract: The invention provides compounds of formula I: ##STR1## wherein A, B, D, X, R.sup.1, and R.sup.3 have any of the values defined in the specification, as well as N-oxides thereof, S-oxides thereof, pharmaceutically acceptable salts thereof, and in vivo hydrolizable esters and amides thereof, that are useful to relieve pain. The invention also provides pharmaceutical compositions as well as synthetic and therapeutic methods relating to such compounds.Type: GrantFiled: February 21, 1997Date of Patent: October 12, 1999Assignee: Zeneca LimitedInventors: Gloria Anne Breault, Howard Tucker, John Oldfield, Peter Warner
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Patent number: 5783593Abstract: The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.Type: GrantFiled: April 29, 1996Date of Patent: July 21, 1998Assignee: Abbott LaboratoriesInventors: William R. Baker, Saul H. Rosenberg, Anthony K. L. Fung, Todd W. Rockway, Stephen A. Fakhoury, David S. Garvey, B. Gregory Donner, Stephen J. O'Connor, Rajnandan N. Prasad, Wang Shen, David M. Stout, Gerard M. Sullivan
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Patent number: 5750731Abstract: A perfluorinated aromatic compound represented by general formula (7): ##STR1## wherein R.sub.3 is a tetravalent perfluorinated aromatic group represented by formula (8): ##STR2## wherein (R.sub.4)s are the same, each being a carboxyl group or a cyano group, or two adjacent (R.sub.4)s combine to form a divalent group represented by formula (10): ##STR3## provided that when R.sub.4 is a cyano group, R.sub.3 denotes said tetravalent perfluorinated aromatic group represented by formula (9).Type: GrantFiled: September 20, 1996Date of Patent: May 12, 1998Assignee: Nippon Telegraph & Telephone CorporationInventors: Shinji Ando, Toru Matsuura, Shigekuni Sasaki, Fumio Yamamoto
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Patent number: 5723658Abstract: The present invention relates to a process for the preparation of salts of substituted or unsubstituted phthalic acids, by reacting a compound of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and are H, F, Cl, Br, CF.sub.3, OH, an alkoxy or alkyl radical in each case having 1 to 4 carbon atoms, or a radical --NR.sup.7 R.sup.8, in which R.sup.7 and R.sup.8 are identical or different and are H, an alkyl radical having 1 to 4 carbon atoms, or a phenyl radical, R.sup.5 and R.sup.6 are identical or different and are H, a --CO-- alkyl group having 1 to 6 carbon atoms in the alkyl radical, or a benzoyl group, or R.sup.5 and R.sup.6 together form a radical of the formula ##STR2## in which R.sup.9, R.sup.10, R.sup.11 and R.sup.12 are identical or different and are H, F, Cl, Br, CF.sub.3, OH, an alkoxy or alkyl radical in each case having 1 to 4 carbon atoms, or a radical --NR.sup.7 R.sup.8, in which R.sup.7 and R.sup.Type: GrantFiled: May 2, 1996Date of Patent: March 3, 1998Assignee: Hoechst AktiengesellschaftInventors: Ralf Pfirmann, Theodor Papenfuhs
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Patent number: 5618839Abstract: The present invention relates to a compound of formula I ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, --CH.sub.2 --NH--, --COCH.sub.2 --, --NHCS--, --CH.sub.2 S--, --CH.sub.2 O--, --OCH.sub.2 --, --NHCH.sub.2 -- or --CR.sup.5 .dbd.CR.sup.6 --;R.sup.m and R.sup.k are independently hydrogen, halogen, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkyloxy or nitro;n is zero or one;R.sup.4 is --(CH.sub.2).sub.t --Y, C.sub.1-6 alkyl, or C.sub.3-6 cycloalkyl;R.sup.1 is --CO.sub.2 Z, C.sub.1-6 alkyl, CH.sub.2 OH, --CONHR.sup.y, or CHO;R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1-6 alkyl;R.sup.a and R.sup.b are independently hydrogen or C.sub.1-6 alkyl; but when n is one, R.sup.a and R.sup.Type: GrantFiled: May 2, 1996Date of Patent: April 8, 1997Assignee: Bristol-Myers Squibb CompanyInventors: John E. Starrett, Jr., Kuo-Long Yu, Muzammil M. Mansuri, David R. Tortolani, Peter R. Reczek
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Patent number: 5545746Abstract: An improved method for recovery of alkali metal or alkaline-earth metal terephthalate and of alkylene glycol, from polyalkylene terephthalate, in particular from polyethylene terephthalate (P.E.T.), alkylene glycol, in particular ethylene glycol produced in the form of vapor during the saponification reaction, initiated by the action of intensive kneading of polyalkylene terephthalate and the alkaline reagent at a temperature of 100.degree. to 200.degree. C. The alkylene glycol is recovered in gaseous form by entrainment by an inert gas or by extraction under low pressure. The alkaline terephthalate or alkaline-earth terephthalate is obtained in solid or powder form; it can easily be stored, transported and redissolved, in order to be purified and possibly transformed into terephthalic acid or ester.Type: GrantFiled: January 3, 1995Date of Patent: August 13, 1996Assignee: Institut Francais du PetroleInventors: Jacques Benzaria, Francois Dawans, Bruno Durif-Varambon, Jean-Bernard Gaillard
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Patent number: 5523476Abstract: A process for producing tetrafluorophthalic anhydride, which comprises chlorinating tetrachlorophthalic anhydride to obtain 3,3,4,5,6,7-hexachloro-1-[3H]-isobenzofuranone, then fluorinating it to obtain 3,4,5,6-tetrafluorophthaloyldifluoride and/or 3,3,4,5,6,7-hexafluoro-1-[3H]-isobenzofuranone, and further reacting the tetrafluorophthalolyldifluoride and/or the hexafluoro-1-[3H]-isobenzofuranone with an inorganic base or an organic acid to obtain tetrafluorophthalic anhydride.Type: GrantFiled: February 21, 1995Date of Patent: June 4, 1996Assignee: Asahi Glass Company Ltd.Inventors: Ryuji Seki, Koji Sugimoto, Seisaku Kumai
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Patent number: 5453538Abstract: A process for the manufacture of aromatic dicarboxylic acids is disclosed using a low bromine to metals ratio facilitated by the use of cerium along with the cobalt and manganese catalyst. Aromatic dicarboxylic acids such as terephthalic acid are useful in the manufacture of fiber, films, bottles and molded products.Type: GrantFiled: February 14, 1994Date of Patent: September 26, 1995Assignee: Amoco CorporationInventors: Jeffrey L. Broeker, Walter Partenheimer, Bruce I. Rosen