Acyclic Patents (Class 564/159)
  • Patent number: 4999427
    Abstract: 2-Alkylpyrimidines are prepared from 1,3-diaminopropane and an appropriate alkanecarboxylic acid in a continuous vapor phase process without isolating any of the reaction intermediates. Improvements in each reaction step, namely, the amidation, the cyclization/dehydration and the dehydrogenation, contribute to the overall success of the continuous vapor phase process.
    Type: Grant
    Filed: May 16, 1988
    Date of Patent: March 12, 1991
    Assignee: DowElanco
    Inventor: John Hull, Jr.
  • Patent number: 4996348
    Abstract: Novel N-alkenoyl enamide of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkyl or halogen, andR.sub.3 and R.sub.4 are each independently of the other C.sub.1 -C.sub.4 alkanolyl, C.sub.1 -C.sub.18 alkoxycarbonyl, benzoyl, phenyl, cyano or carbamoyl, and R.sub.4 can also be hydrogen,are used for photocrosslinkable compositions suitable for use in photographic solutions, as UV absorbers and as textile finishing agents.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: February 26, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Martin Kuhn, Philippe Ouziel
  • Patent number: 4992584
    Abstract: A process is disclosed for the preparation of .beta.-ketocarboximides of .alpha.,.beta.-unsaturated amides from 1,3-dioxin-4-ones and .alpha.,.beta.-unsaturated amides using an inert solvent system capable of maintaining both reactants substantially in homogeneous solution throughout the reaction. This process provides greatly improved yields of .alpha.,.beta.-ketocarboximides of .alpha.,.beta.-unsaturated amides as well as a simple method of recovering same since such products can readily be precipitated from the reaction mixture.
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: February 12, 1991
    Assignee: Eastman Kodak Company
    Inventor: Robert J. Clemens
  • Patent number: 4990536
    Abstract: The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable salt thereof: ##STR1## wherein X represents ##STR2## or --(CH.sub.2).sub.n --, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group,n is an integer of 3 or 5, andR represents --(CH.sub.2).sub.4 --R.sub.1 (wherein R.sub.1 is --NH.sub.2 or --OH), --(CH.sub.2).sub.3 --R.sub.2 (wherein R.sub.2 is --COOH or --CHO), --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.3 --OH or --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.2 --R.sub.2 (wherein R.sub.2 is as defined above).
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: February 5, 1991
    Assignees: Nippon Kayaku Kabushiki Kaisha, Takara Shuzo Co., Ltd.
    Inventors: Takeji Sakasai, Tsugio Tomiyoshi, Keiko Watanabe, Kyuichi Nemoto, Tetushi Saino, Yoshihisa Umeda
  • Patent number: 4987257
    Abstract: Disclosed is a diacetylene compound comprising, as structural units, (a) at least one member selected from diacetylene group-containing organic groups of the formulae (I) and (II):R.sup.I --C.tbd.C--C.tbd.C--R.sup.II -- (I)and--R.sup.III --C.tbd.C--C.tbd.C--R.sup.IV -- (II)wherein R.sup.I is hydrogen or a (C1-16) monovalent organic group, and R.sup.II, R.sup.III and R.sup.IV are a (C1-13) divalent organic group, (b) at least one organic group having at least one carbon-to-carbon double bond, and (c) at least one connecting group connecting the units (a) and (b), which connecting group is selected from amide, imide, ester, ether, amino, imino, urethane, sulfonyl and carbonyl bonds. A cured shaped article made of this compound exhibits isotropically a high elastic modulus and has excellent mechanical properties.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: January 22, 1991
    Assignee: Director-General of Agency of Industrial Science and Technology
    Inventors: Katsuyuki Nakamura, Satoru Yamazaki, Jinichiro Kato, Kensaku Tokushige
  • Patent number: 4983328
    Abstract: N-[4-(3-Aminopropyl)aminobutyl]-2-(.omega.-guanidino-fatty acid-amido)-2-substituted-ethanamides represented by the general formula ##STR1## wherein Y represents --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH or ##STR2## R represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms which may have a hydroxyl group as substituent, or a benzyl group, and n is an integer of from 1 to 8, provided that when Y is ##STR3## and n is 4, R represents the groups other than the hydrogen atom; salt thereof having antitumor activity in experimental animal tumors and a process for the preparation thereof is provided.
    Type: Grant
    Filed: March 15, 1988
    Date of Patent: January 8, 1991
    Assignee: Bristol-Myers Company
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Hironobu Iinuma, Daishiro Ikeda, Teruya Nakamura, Akio Fujii
  • Patent number: 4968841
    Abstract: Ethylidene bisformamide is produced in high selectivity by the reaction of formamide with vinyl acetate in a molar ratio of at least 1:1 at a temperature from about 60.degree. to 150.degree. C. in the presence of a catalyst comprising an acid salt of mercury of which the parent acid has a pKa less than about 3.8.
    Type: Grant
    Filed: November 14, 1989
    Date of Patent: November 6, 1990
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Mark L. Listemann, Ronald Pierantozzi, Robert K. Pinschmidt, Jr.
  • Patent number: 4960540
    Abstract: The present invention involves new anti-foam compositions which control foaming in aqueous systems and by nature of their inverse cloud point characterisitics are insoluble and particulate above their inverse cloud point, and soluble below it. This property makes them particulate non-depositing defoamers. As the defoamed aqueous system cools down these novel products become soluble, preventing insoluble material (pitch) from depositing on process equipment and matter being processed. The anitfoam composition is an alkoxylated bis-amide of the following formula: ##STR1## where R.sup.1 is ##STR2## R.sup.2 is --(CH.sub.2).sub.a --; R.sup.3 is alkyl C.sub.12 to C.sub.20 ; ##STR3## x,y,z are each independently integers from 0 to 20; a is an integer from 1 to 5;c is an integer from 0 to 5;R.sup.5 is selected from H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.6.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: October 2, 1990
    Inventors: Thomas C. Friel, Jr., Anthony J. O'lenick, Jr.
  • Patent number: 4958005
    Abstract: A fluorine-containing composition represented by formula (I) ##STR1## wherein X represents a group containing a polyfluoroaliphatic group having from 3 to 26 carbon atoms; R represents a hydrogen atom or an aliphatic group having from 1 to 3 carbon atoms; n represents an integer of from 2 to 3; p represents an integer of from 1 to 100; and Y represents a group represented by formula (II) or formula (III) ##STR2## wherein R represents a hydrogen atom or an aliphatic group having from 1 to 3 carbon atoms; n represents an integer of from 2 to 3; and Z represents an iodine atom, a sulfonate group, or a sulfate group, ##STR3## wherein R represents a hydrogen atom or an aliphatic group having from 1 to 3 carbon atoms; n represents an integer of from 2 to 3; and Z.sup.1 represents an iodine atom, a bromine atom, a chlorine atom, or a hydroxyl group; and a process for preparing the same.
    Type: Grant
    Filed: September 20, 1988
    Date of Patent: September 18, 1990
    Assignee: Daikin Industries, Ltd.
    Inventors: Takeo Saegusa, Masatoshi Miyamoto, Yoshiyuki Sano
  • Patent number: 4923642
    Abstract: Quaternary ammonium compounds containing one or two long-chain ester or amide radicals of etherified hydroxycarboxylic acids and, for the remainder, short-chain radicals, which are liquid to pasty substances that may readily be dissolved or dispersed in water or alcohol/water mixtures. They may be used in dilute or concentrated, storable form for softening fabrics without the absorbency of the treated fabrics being adversely affected. The quaternary ammonium compounds are obtained by reaction of epoxyfatty acid esters with amines and subsequent quaternization.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: May 8, 1990
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Horst Rutzen, Horst Baumann, Bert Gruber
  • Patent number: 4918222
    Abstract: An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: April 17, 1990
    Assignee: Texaco Inc.
    Inventors: Jiang-Jen Lin, John F. Knifton, Ernest L. Yeakey
  • Patent number: 4914223
    Abstract: A composition of matter comprising an acrylamido-acyl or methacrylamido-acyl oligomer derived from at least one nucleophilic oligomer having at least one amino-, hydroxyl-, or thio-substituted polyoxyalkylene, polyalkyleneimine, polyester, polyolefin, polyacrylate, or polysiloxane oligomer, said nucleophilic oligomer having a molecular weight in the range of 200 to 20,000 is disclosed. Also disclosed are free radically polymerizable monomer-containing compositions containing said oligomers as well as acrylamido- and methacrylamido-acylated polymers which are the thermal or photocured products of said oligomers. In addition, a process is disclosed for providing said acrylamido- and methacrylamido-acylated oligomers which are useful, for example, in coatings, films, printing inks, adhesives, and saturants.
    Type: Grant
    Filed: August 17, 1988
    Date of Patent: April 3, 1990
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Jerald K. Rasmussen, Steven M. Heilmann, Frederick J. Palensky
  • Patent number: 4914225
    Abstract: A polymer comprising a carbon-carbon backbone chain and at least one N-(substituted oxalyl)carbamoyl group of the formula: --CO--NH--CO--CO--OR wherein R is a hydrocarbon group as a side chain attached to said backbone chain.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: April 3, 1990
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Yuji Suzuki, Satoshi Urano, Hirotoshi Umemoto, Ryuzo Mizuguchi, Kei Aoki, Noriyuki Tsuboniwa
  • Patent number: 4898900
    Abstract: Novel derivatives of 3,3'-oxy-bis{[2,2'-di(bromomethyl)]propanoic acid}of formula (1) ##STR1## in which Y represents OR, chlorine or NH--R and wherein R represents hydrogen or an alkyl, aralkyl or aryl group, in which the alkyl, aryl and aralkyl groups are unsubstituted or substituted with 1 to 5 bromine atoms, are described.The novel derivatives of the invention have improved thermal properties and a high content of bromine, and are particularly suitable as flame-retardant agents. Methods of preparation of these novel compounds are described.
    Type: Grant
    Filed: December 27, 1988
    Date of Patent: February 6, 1990
    Assignee: Bromine Compounds Ltd.
    Inventor: Michael Peled
  • Patent number: 4898930
    Abstract: Peptide ester and amide derivatives of the general formula I: ##STR1## in which X is H or an acyl, A and B are structurally defined amino acid residues, n is an integer of from 1 to 3, R.sup.1 is H or a lower alkyl and either R.sup.2 or C is a defined optionally modified amino acid residue and the other is a lower alkoxyl, an amino group or a direct chemical bond, are converted under physiologic conditions, by enzymic hydrolysis in pathologically altered tissues and subsequent spontaneous cyclization, into pharmacodynamically active spirocyclic peptide derivatives of the general formula III: ##STR2## in which R.sup.3 and R.sup.4 are H atoms, optionally substituted alkyl groups or jointly an aliphatic chain forming preferably a 2,5- piperazinedione ring, and hence can act as pro-farmaca (drug precursors) of prolonged biological effect.
    Type: Grant
    Filed: June 12, 1987
    Date of Patent: February 6, 1990
    Assignee: Spofa, spojene podniky pro
    Inventors: Evzen Kasafirek, Miroslav Rybak, Ivan Krejci, Antonin Sturc, Alena Roubalova, Jiri Vanzura, Evzen Krepela, Michal Bartik
  • Patent number: 4892687
    Abstract: A process is disclosed for producing N-acetyl-aminoacid which comprises reacting a feedstock from the group consisting of simple olefins, acetamide and synthesis gas with a catalyst comprising a cobalt-containing compound promoted by a bidental-phosphine ligand in a solvent at a pressure of 500 psi or greater and a temperature of 50.degree. C. or greater. The presence of the ligand increases both reaction rate and cobalt catalyst stability.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: January 9, 1990
    Assignee: Texaco Inc.
    Inventor: Jiang-Jen Lin
  • Patent number: 4892806
    Abstract: The invention provides water soluble surface active compounds having the formula ##STR1## wherein each of R.sup.1 and R.sup.2 independently is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted aryl, provided that not both R.sup.1 and R.sup.2 are hydrogen,and each of x and y independently is an integer from 3 to 6.In a preferred embodiment where discrete compounds are required, R.sup.1 and R.sup.2 are identical and x and y are identical.Particularly preferred compounds are those wherein each of R.sup.1 and R.sup.2 is an alkyl group having from 5 to 8 carbon atoms, more preferably from 6 to 7 carbon atoms, and each of x and y is an integer from 3 to 6.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: January 9, 1990
    Assignee: Eastman Kodak Company
    Inventors: Catherine B. A. Briggs, Alan R. Pitt
  • Patent number: 4866141
    Abstract: C.sub.5 -C.sub.9 lactone derived materials are made by simultaneously reacting (a) a C.sub.5 -C.sub.9 lactone with (b) a polyamine, a polyol or an amino alcohol and (c) a hydrocarbyl substituted C.sub.4 -C.sub.10 monounsaturated dicarboxylic acid producing material, e.g., a polyisobutenyl succinimide, which preferably was made by reacting a polymer of a C.sub.2 to C.sub.10 monoolefin, preferably polyisobutylene, having a molecular weight of about 300 to 10,000 with a C.sub.4 to C.sub.10 monounsaturated acid, anhydride or ester, preferably maleic anhydride, such that there are 0.7 to 2.0 dicarboxylic acid producing moieties per molecule of said olefin polymer used in the reaction mixture. The resulting lactone derived materials, which may be post-treated, for example, with a boron compound, are useful, per se, as oil soluble dispersant additives, and are useful in fuel and lubricating oil compositions including concentrates containing the additives.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: September 12, 1989
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Antonio Gutierrez, Robert D. Lundberg
  • Patent number: 4866135
    Abstract: Polymer C.sub.5 -C.sub.9 derivatives are made by reacting a C.sub.5 -C.sub.9 lactone with an aminoalkyl derivative, e.g., N-(3-aminopropyl) morpholine, to form an adduct having a hydroxyl group on one end thereof and a tertiary amino nitrogen-containing heterocyclic ring group on the other end thereof, and then reacting the adduct with an ethylene-C.sub.3 to C.sub.28 alpha-olefin copolymer or terpolymer which has from about 0.2 to about 5 wt. % of ethylenically unsaturated carboxylic acid units grafted thereto, e.g., maleic anhydride ethylene-propylene copolymer. The resulting polymeric C.sub.5 -C.sub.9 lactone derivatives are usful per se as multifunctional oil soluble additives for fuel and lubricating oil compositions, including concentrates containing the additives.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: September 12, 1989
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Antonio Gutierrez, Robert D. Lundberg
  • Patent number: 4866140
    Abstract: C.sub.5 -C.sub.9 lactone based adduct materials are made by reacting a C.sub.5 -C.sub.9 lactone with a polyamine, a polyol or an amino alcohol to form a lactone adduct intermediate, and thereafter reacting the intermediate with a hydrocarbyl substituted C.sub.4 -C.sub.10 monounsaturated dicarboxylic acid producing material, e.g., a polyisobutenyl succinimide, which, in turn, preferably was made by reacting a polymer of a C.sub.2 to C.sub.10 monoolefin, preferably polyisobutylene, having a molecular weight of about 300 to 10,000 with a C.sub.4 to C.sub.10 monounsaturated acid, anhydride or ester, preferably maleic anhydride, such that there are 0.7 to 2.0 dicarboxylic acid producing moieties per molecule of said olefin polymer used in the reaction mixture. The resulting adduct material are useful per se, as oil soluble dispersant additives, and are useful in fuel and lubricating oil compositions including concentrates containing the additives.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: September 12, 1989
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Antonio Gutierrez, Robert D. Lundberg
  • Patent number: 4864055
    Abstract: A compound represented by the following formula: ##STR1## wherein R is a C.sub.3 -C.sub.24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable,R.sup.1 is hydrogen or a C.sub.1 -C.sub.4 alkyl radical, orR and R.sup.1 together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable,R.sup.2 and R.sup.3 are hydrogen, a C.sub.1 -C.sub.4 alkyl or acyl radical, orR.sup.2 and R.sup.3 together are a C.sub.1 -C.sub.4 alkylene group,R.sup.4 is hydrogen or a C.sub.1 -C.sub.4 alkyl, acyl, ester, amide or acid group, andn is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R.sup.2 and R.sup.3 are methyl and R.sup.1 and R.sup.4 are hydrogen.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: September 5, 1989
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Robert K. Pinschmidt, Jr., Dale D. Dixon, William F. Burgoyne, Jr.
  • Patent number: 4855286
    Abstract: The invention relates to compounds of the formula ##STR1## in which R.sup.1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: August 8, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Heinz-Werner Kleemann, Dieter Ruppert, Bernward Scholkens
  • Patent number: 4837290
    Abstract: A composition of matter comprising an acrylamido-acyl or methacrylamido-acyl oligomer derived from at least one nucleophilic oligomer having at least one amino-, hydroxyl-, or thiol-substituted polyoxyalkylene, polyalkyleneimine, polyester, polyolefin, polyacrylate, or polysiloxane oligomer, said nucleophilic oligomer having a molecular weight in the range of 200 to 20,000 is disclosed. Also disclosed are free radically polymerizable monomer-containing compositions containing said oligomers as well as acrylamido- and methacrylamido-acylated polymers which are thermal or photocured products of said oligomers. In addition, a process is disclosed for providing said acrylamido- and methacrylamido-acylated oligomers which are useful, for example, in coatings, films, printing inks, adhesives, and saturants.
    Type: Grant
    Filed: July 11, 1988
    Date of Patent: June 6, 1989
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Jerald K. Rasmussen, Steven M. Heilmann, Frederick J. Palensky
  • Patent number: 4820691
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds interevene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
    Type: Grant
    Filed: June 24, 1987
    Date of Patent: April 11, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Dinesh V. Patel
  • Patent number: 4801721
    Abstract: Methods for the alkylation of substituted amines with trifluorate esters is disclosed.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: January 31, 1989
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: 4791230
    Abstract: A series of hydroxy-terminated amides has been discovered. They are of the formulae:R--[NHCO(CH.sub.2).sub.z OH].sub.2andR--[NHCO(CH.sub.2 OCH.sub.2 OCH.sub.2 CH.sub.2 OH)].sub.2wherein:R is a polyoxyethylene radical of 1 to 9 mers which is optionally capped at both ends with 1 or 2 propylene oxide mers, and z is 3 or 5.The amides are water soluble and cold acetone insoluble. They are useful in flexible polyurethane foams.
    Type: Grant
    Filed: March 30, 1988
    Date of Patent: December 13, 1988
    Assignee: Texaco Chemical Company
    Inventors: Jiang-Jen Lin, George P. Speranza
  • Patent number: 4788300
    Abstract: A process for preparing compounds (1) ##STR1## where Y is NR.sup.1 R.sup.2 or OR, R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 alkyl, and R is C.sub.1-3 alkyl, which comprises protecting the hydroxy group of a compound (2) ##STR2## cyclizing the product under basic conditions and removing the protecting group.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: November 29, 1988
    Assignee: I.S.F. Societa per Azioni
    Inventors: Mario Pinza, Ugo C. Pfeiffer
  • Patent number: 4777276
    Abstract: A composition of matter comprising an acrylamido-acyl or methacrylamido-acyl oligomer derived from at least one nucleophilic oligomer having at least one amino-, hydroxyl-, or thiol-substituted polyoxyalkylene, polyalkyleneimine, polyester, polyolefin, polyacrylate, or polysiloxane oligomer, said nucleophilic oliogmer having a molecular weight in the range of 200 to 20,000 is disclosed. Also disclosed are free radically polymerizable monomer-containing compositions containing said oligomers as well as acrylamido- and methacrylamido-acylated polymers which are the thermal or photocured products of said oligomers. In addition, a process is disclosed for providing said acrylamido- and methacrylamido-acylated oligomers which are useful, for example, in coatings, films, printing inks, adhesives, and saturants.
    Type: Grant
    Filed: October 29, 1981
    Date of Patent: October 11, 1988
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Jerald K. Rasmussen, Steven M. Heilmann, Frederick J. Palensky
  • Patent number: 4708963
    Abstract: Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is OR.sub.2, wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or NHR.sub.3, wherein R.sub.3 is an acid residue or hydrogen;X is oxygen;A is --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C--;W is free or functionally modified hydroxymethylene or free or functionally modified ##STR2## wherein the OH-group can be in the .alpha.- or .beta.-position; D is a straight-chain or branched, saturated or unsaturated aliphatic group of 1-10 carbon atoms, which can optionally be substituted by fluorine atoms, 1,2-methylene, 1,1-trimethylene;E is --C.tbd.C-- or --CR.sub.6 .dbd.CH.sub.7 -- wherein R.sub.6 and R.sub.7 are hydrogen or alkyl of 1-5 carbon atoms;R.sub.4 is an aliphatic group, cycloalkyl, optionally substituted aryl, or a heterocyclic group;R.sub.5 is free or functionally modified hydroxy and,when R.sub.
    Type: Grant
    Filed: May 28, 1985
    Date of Patent: November 24, 1987
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Bernd Raduchel, Norbert Schwarz, Helmut Vorbruggen, Jorge Casals-Stenzel, Ekkehard Schillinger, Michael H. Town
  • Patent number: 4692533
    Abstract: Prepare N-(amidoalkyl)imides by contacting an imide with a 2-oxazoline under reaction conditions, optionally in the presence of a solvent.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: September 8, 1987
    Assignee: The Dow Chemical Company
    Inventors: Pen-Chung Wang, Steven P. Crain
  • Patent number: 4673562
    Abstract: A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.
    Type: Grant
    Filed: August 19, 1983
    Date of Patent: June 16, 1987
    Assignees: The Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Alan Davison, David Brenner, John Lister-James, Alun G. Jones
  • Patent number: 4668703
    Abstract: This invention is for .gamma.-allenyl-.gamma.-aminobutyric acid derivatives which are .gamma.-aminobutyric acid transaminase inhibitors.
    Type: Grant
    Filed: July 1, 1985
    Date of Patent: May 26, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Alexander Krantz, Arlindo L. Castelhano, Diana H. Pliura
  • Patent number: 4665228
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen, halogen, C.sub.1-6 alkyl, or haloalkyl; R.sub.4 is hydrogen; C.sub.1-4 alkyl, alkenyl, alkoxy, haloalkyl; C.sub.1-2 alkylamino, C.sub.1-2 alkylthio, C.sub.2-4 cycloalkyl, C.sub.2-6 alkoxyalkyl, C.sub.2-6 alkylthiomethyl, amino, phenoxy, phenamino, or furan; and R.sub.5 is hydrogen or C.sub.1-4 alkyl, are useful to retard the growth of turf grass.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: May 12, 1987
    Assignee: Monsanto Company
    Inventors: Gerhard H. Alt, John P. Chupp, Lane A. Clizbe
  • Patent number: 4661288
    Abstract: Water-soluble zwitterionic compounds having clay soil removal/anti-redeposition properties. The zwitterionic compounds are selected from monozwitterionic compounds, dizwitterionic compounds, polyzwitterionic compounds, and zwitterionic polymers. These zwitterionic compounds are useful in detergent compositions at from about 0.05 to about 95% by weight. In addition to the zwitterionic compounds, the detergent compositions further comprise from about 1 to about 75% by weight of a nonionic, anionic, ampholytic, zwitterionic, or cationic detergent surfactant or mixture thereof.
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: April 28, 1987
    Assignee: The Procter & Gamble Company
    Inventors: Donn N. Rubingh, Eugene P. Gosselink
  • Patent number: 4658036
    Abstract: A process is disclosed for preparation of invert emulsifiers useful for oil-base drilling muds. The emulsifiers are prepared by reacting at least one tall oil fatty acid with acrylic acid, maleic anhydride or fumaric acid. The product of this reaction is substantially reacted with diethylene triamine, and at least one tall oil fatty acid to give the invert emulsifier.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: April 14, 1987
    Assignee: Westvaco Corporation
    Inventor: Peter Schilling
  • Patent number: 4658058
    Abstract: The novel compound N-[(3-aminoproypl)aminobutyl]-Z-(F-guandino-3-hydroxyheptanamido)-2-methox yethanamide or a pharmaceutically acceptable salt thereof which has antitumor activity in experimental animals.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: April 14, 1987
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Hironobu Iinuma, Daishiro Ikeda, Teruya Nakamura, Akio Fujii
  • Patent number: 4639468
    Abstract: A glycinamide derivative of the general formula I: ##STR1## wherein: R is a linear or ramified alkyl group C.sub.5 -C.sub.18, a linear or ramified alkenyl group C.sub.5, C.sub.6, C.sub.7, C.sub.8, C.sub.9, C.sub.10, C.sub.11, C.sub.12, C.sub.13, C.sub.14, C.sub.15, C.sub.16, C.sub.17 or C.sub.18, a linear or ramified alkynyl group C.sub.4 -C.sub.10, a linear or ramified acyl group C.sub.4 -C.sub.18, a linear or ramified alkyl group C.sub.1 -C.sub.10, substituted by a phenoxy group, by a hydroxy radical, by an acetoxy radical, by a carboxy radical, by a linear or ramified alkoxycarbonyl group C.sub.1 -C.sub.4, by a carbonyl radical, by a carboxaldehyde group, by an acetal or cetal group, by one or more phenyl groups, by one or more phenyl groups substituted by a halogen atom such as fluorine, chlorine or bromine,R.sub.1 represents hydrogen, a linear or ramified alkyl group C.sub.1, C.sub.2, C.sub.3, C.sub.4, C.sub.5, C.sub.6, C.sub.7, C.sub.8, C.sub.9 or C.sub.10, a linear or ramified acyl group C.sub.1 -C.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: January 27, 1987
    Assignee: Continental Pharma Inc.
    Inventors: Romeo Roncucci, Claude L. Gillet, Alexis H. Cordi, Mark A. Martens, Joseph L. Roba, Paul J. Niebes, Georges E. Lambelin, William R. Van Dorsser
  • Patent number: 4628110
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: October 30, 1984
    Date of Patent: December 9, 1986
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4623383
    Abstract: The present invention relates to novel N- and optionally N'-substituted (N-dichloroacetyl)glycine amides of the formula I with antidote action, to antidote compositions containing such compounds, to selective herbicide compositions containing these antidotes together with herbicidally active compounds and to a method for treating cultivated plants with said compositions.
    Type: Grant
    Filed: July 23, 1984
    Date of Patent: November 18, 1986
    Assignee: Eszakmagyarorszagi Vegyimuvek
    Inventors: Erzsebet Grega nee Toth, Jozsef Nagy, Gyula Tarpai, Erno Lorik, Istvan Toth, Karoly Pasztor, Zsuzsanna Bartfai nee Harsanyi, Ilona Beres, Laszlo Tasi, Eszter Urszin nee Simon, Zsolt Dombay, Judit Bajusz nee Olah, Karoly Balogh
  • Patent number: 4616088
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: October 7, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
  • Patent number: 4600796
    Abstract: A process for preparing a class of polyols resulting from the reaction of a bicyclic amide acetal with an alkanolamine is described.
    Type: Grant
    Filed: June 3, 1985
    Date of Patent: July 15, 1986
    Assignee: Ashland Oil, Inc.
    Inventor: Anil B. Goel
  • Patent number: 4588823
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: May 13, 1986
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4581170
    Abstract: Processes for preparing the useful intermediates having the formula ##STR1## are disclosed herein, utilizing novel chemical compounds having the formula ##STR2##
    Type: Grant
    Filed: August 3, 1984
    Date of Patent: April 8, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard H. Mueller, Jakob-Matthias Drossard, Peter H. Ermann
  • Patent number: 4579581
    Abstract: Herbicidal and fungicidal benzamide derivatives of the formula (I) ##STR1## wherein R.sup.1 is an optionally substituted alkyl, alkenyl, aryl, heterocyclyl, benzyl, or heterocyclylmethyl radical;R.sup.2 is hydrogen, or an optionally substituted alkyl, alkenyl, benzyl, or heterocyclylmethyl, radical;X is oxygen, sulphur, or an --NH-- group;R.sup.3 is an optionally substituted alkyl or alkenyl radical when X is oxygen or sulphur, or is an optionally substituted alkanoyl radical when X is --NH--;and E is a --CN, --CONH.sub.2, --CSNH.sub.2, or --CONR.sup.4 R.sup.5 group wherein each R.sup.4 and R.sup.5 is an optionally substituted alkyl or alkenyl group.
    Type: Grant
    Filed: February 22, 1984
    Date of Patent: April 1, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventors: Ian T. Kay, David Bartholomew, Emyr G. Williams, Robert A. Noon
  • Patent number: 4578515
    Abstract: Ethylidene bisformamide is prepared by reacting, at elevated temperatures, dry acetaldehyde and formamide in the presence of an acidic catalyst and an ammonia scavenger such as acetic anhydride. The bisformamide is recovered as a bottoms product of high speed low residence time distillation techniques, e.g., wiped film evaporation. The resulting ethylidene bisformamide may be cracked to N-vinylformamide, which monomer is useful in the preparation of active polymers and copolymers, including poly(vinylformamide) which can be hydrolyzed to poly(vinylamine) salts by contact with acid. These amine salts can then be converted to the free amines, which are precursors of polymeric dyes and pharmaceuticals.
    Type: Grant
    Filed: June 7, 1984
    Date of Patent: March 25, 1986
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Daniel J. Dawson, Kenneth M. Otteson
  • Patent number: 4577042
    Abstract: A complex of a tetradentate tetraanionic ligand L of the formula: ##STR1## and a metal, preferably a transition metal, is described. The chelate and ring Z-CH-M-Z functional groups Z, such as N or O are resistant to oxidation and the ring contains 4 to 7 preferably 5 to 6 chain atoms. An osmium complex containing two pyridine ligands is an oxidation catalyst. Further activation by anodic oxidation and heating to a temperature exceeding 30.degree. C. greatly increases catalytic activity.
    Type: Grant
    Filed: March 17, 1983
    Date of Patent: March 18, 1986
    Assignee: California Institute of Technology
    Inventors: Terrence J. Collins, Fred C. Anson, Stephen L. Gipson, Terry E. Krafft
  • Patent number: 4556497
    Abstract: Amides of certain ether diamines are provided. These compounds give excellent results when tested in lubricants as friction reducing additives.
    Type: Grant
    Filed: June 29, 1983
    Date of Patent: December 3, 1985
    Assignee: Mobil Oil Corporation
    Inventors: Andrew G. Horodysky, Robert M. Gemmill, Jr.
  • Patent number: 4552678
    Abstract: The invention relates to novel compounds which are particularly suitable as corrosion inhibitors for aqueous liquids for the cleaning of metals, and especially as corrosion inhibitors for oil-free aqueous liquids used for the working of metals, in particular those exposed to corrosion. The compounds according to the invention correspond to the formula ##STR1## The invention also relates to a process for their preparation.
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: November 12, 1985
    Inventors: Francesco Cargnino, Giuseppe Natoli, Horst Lorke
  • Patent number: 4548744
    Abstract: Water-soluble ethoxylated amine oxides having clay soil removal/anti-redeposition properties are disclosed herein. These amine oxides are selected from ethoxylated monoamine oxides, ethoxylated diamine oxides, ethoxylated polyamine oxides, ethoxylated amine oxide polymers, and mixtures thereof. These amine oxides are useful at from about 0.05 to about 95% by weight in detergent compositions which further comprise from about 1 to about 75% by weight of a nonionic, anionic, ampholytic, zwitterionic, or cationic detergent surfactant or mixture thereof. In addition to these detergent surfactants, the detergent composition can optionally comprise from 0 to about 80% by weight of a detergent builder.
    Type: Grant
    Filed: July 22, 1983
    Date of Patent: October 22, 1985
    Inventor: Daniel S. Connor
  • Patent number: 4536314
    Abstract: Detergent compositions, detergent additive products and bleaching compositions containing aliphatic peroxyacid bleach precursors of formula ##STR1## are provided, where L is a leaving group of defined formula whose conjugate acid has a pKa of from 6 to 13 and ##STR2## is a non linear acyl group, the carboxylic acid derivative of which has a logP.sub.OCT in the range from 1.9 to 4.0 (where P.sub.OCT is the partition coefficient between octanol and water). New precursor compounds are provided in which ##STR3## is a C.sub.7 -C.sub.17 branched aliphatic acyl group containing a linear chain of at least 5 carbon atoms extending from and including the carbonyl carbon wherein the branching is on at least the 2- and/or 3- carbon atom.
    Type: Grant
    Filed: February 22, 1984
    Date of Patent: August 20, 1985
    Assignee: The Procter & Gamble Company
    Inventors: Frederick E. Hardy, David J. Kitko, Cushman M. Cambre