Guanyl Hydrazines Or Hydrozones (i.e., Hnh-n=c(-hnh)-hnh Or Hn=c(-hnh)-nh Hnh, Wherein Substitution May Be Made For Hydrogen Only) Patents (Class 564/227)
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Patent number: 10905663Abstract: This invention discloses methods and compositions for the treatment of demyelinating disorders. Specifically, the invention relates to the use guanabenz or guanabenz derivative for treating demyelinating disorders.Type: GrantFiled: March 5, 2014Date of Patent: February 2, 2021Assignee: The University of ChicagoInventors: Sharon Way, Benjamin Clayton, Brian Popko
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Patent number: 9815777Abstract: Metformin salts of 2,4-thiazolidinediones are described for the treatment of diabetes mellitus Type2, gestational diabetes, polycystic ovary syndrome, non-alcoholic fatty liver disease, coronary artery disease, pancreatic cancer, premature puberty, and other diseases which manifest insulin resistance.Type: GrantFiled: September 20, 2014Date of Patent: November 14, 2017Assignee: Jiva Pharma, Inc.Inventor: Om P Goel
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Patent number: 8975426Abstract: A method of forming a product from an oil feedstock, such as a biodiesel product, and a heterogeneous catalyst system used to form said product is disclosed. This catalyst system, which has a high tolerance for the presence of water and free fatty acids (FFA) in the oil feedstock, may simultaneously catalyze both the esterification of FAA and the transesterification of triglycerides present in the oil feedstock. The catalyst system is comprised of a mixture of zinc oxide and a second metal oxide. The zinc oxide includes a mixture of amorphous zinc oxide and zinc oxide nanocrystals, the zinc nanocrystals having a mean grain size between about 20 and 80 nanometers with at least one of the nanocrystals including a mesopore having a diameter of about 5 to 15 nanometers. Preferably, the second metal oxide is a lanthanum oxide, the lanthanum oxide being selected as one from the group of La2CO5, LaOOH, and combinations or mixtures thereof.Type: GrantFiled: June 16, 2010Date of Patent: March 10, 2015Assignee: Wayne State UniversityInventors: Shuli Yan, Steven O. Salley, K. Y. Simon Ng
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Publication number: 20140377345Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.Type: ApplicationFiled: September 9, 2014Publication date: December 25, 2014Inventors: John McKearn, Jeremy Blitzer
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Patent number: 8858991Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.Type: GrantFiled: January 19, 2012Date of Patent: October 14, 2014Assignee: Pathologica LLCInventors: John McKearn, Jeremy Blitzer
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Patent number: 8853276Abstract: The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): The invention also relates to the process for preparing said guanidine derivatives and also to synthetic intermediates. Finally, the invention relates to the use of the guanidine derivatives for the preparation of compositions with anti-glycation properties, especially in cosmetology.Type: GrantFiled: September 6, 2011Date of Patent: October 7, 2014Assignee: Produits Chimiques Auxiliaires et de SyntheseInventors: Sylvain Rault, Jean Charles Lancelot, Peggy Suzanne, Anne-Sophie Voisin-Chiret, Regis Pecquet, Jean-Christophe Joseph
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Publication number: 20120269891Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.Type: ApplicationFiled: January 19, 2012Publication date: October 25, 2012Applicant: PATHOLOGICA LLCInventors: John McKearn, Jeremy Blitzer
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Patent number: 8247455Abstract: The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of making.Type: GrantFiled: December 7, 2010Date of Patent: August 21, 2012Assignee: Ferring B.V.Inventor: Thais Sielecki-Dzurdz
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Patent number: 7960501Abstract: A catalyst obtained by calcining a hydrazone metal complex in which at least one catalytic metal species is coordinated to a hydrazone compound represented by a General Formula (1) below, a hydrazone polymer compound including at least a structural unit derived from a hydrazone compound represented by the General Formula (1) below as a repeating unit, and a catalyst obtained by calcining a hydrazone polymer metal complex in which at least one catalytic metal species is coordinated to a hydrazone polymer compound including at least a structural unit derived from a hydrazone compound represented by the General Formula (1) below: wherein, Py represents a 2-pyridyl group, a 3-pyridyl group, or a 4-pyridyl group.Type: GrantFiled: August 29, 2008Date of Patent: June 14, 2011Assignees: Toyota Jidosha Kabushiki Kaisha, National University Corporation Nagoya Institute of TechnologyInventors: Hideki Masuda, Tatsuya Fujii, Haruyuki Nakanishi, Shinichi Matsumoto, Hidekazu Arikawa
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Patent number: 7951903Abstract: A hydrazone compound represented by a General Formula (1) below, a hydrazone compound for forming a metal complex, which is represented by the General Formula (1) below and forms a metal complex by coordination to at least one metal species, a ligand for forming a metal complex including the hydrazone compound, and a monomer for manufacturing a polymer compound including the hydrazone compound: wherein, Py represents a 2-pyridyl group, a 3-pyridyl group, or a 4-pyridyl group.Type: GrantFiled: August 29, 2008Date of Patent: May 31, 2011Assignees: Toyota Jidosha Kabushiki Kaisha, Ihara Chemical Industry Co., Ltd.Inventors: Haruyuki Nakanishi, Shinichi Matsumoto, Hidekazu Arikawa, Hironobu Kumagai
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Patent number: 7932422Abstract: The invention relates to chlorine Guanabenz derivatives for treating Huntington's disease and other polyglutamine expansion associated diseases. More specifically, it relates to the use of the molecule of formula (I) wherein R?H or Cl and the phenyl group is at least substituted twice, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating polyglutamine expansion associated diseases.Type: GrantFiled: October 3, 2007Date of Patent: April 26, 2011Inventors: Anne Bertolotti, Marc Blondel
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Patent number: 7863334Abstract: The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of making.Type: GrantFiled: September 17, 2007Date of Patent: January 4, 2011Assignee: Cytokine PharmaSciences, Inc.Inventor: Thais M. Sielecki-Dzurdz
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Patent number: 7291647Abstract: The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of making.Type: GrantFiled: August 17, 2005Date of Patent: November 6, 2007Assignee: Cytokine Pharmasciences, Inc.Inventor: Thais Sielecki-Dzurdz
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Patent number: 6660246Abstract: Novel compounds of the formula and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods.Type: GrantFiled: August 9, 1996Date of Patent: December 9, 2003Assignee: Bracco International, BVInventors: David P. Nowotnik, Palaniappa Nanjappan
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Publication number: 20030191310Abstract: The present invention relates to a method for producing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) by cyclization reaction from &agr;-oxo-2,3-dichlorophenylacetamidino-aminoguanidino-hydrazone.Type: ApplicationFiled: May 15, 2003Publication date: October 9, 2003Inventors: Geza Schneider, Csaba Lehel Geg, Levente Ondi, Attila Gergely Mate, Ferenc Lukacs, Miklos Nyerges, Sandor Garaczi
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New guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions
Publication number: 20010025055Abstract: The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.Type: ApplicationFiled: March 23, 2001Publication date: September 27, 2001Inventors: Eberhard Amtmann, Norbert Frank, Gerhard Sauer, Gerhard Schilling -
Patent number: 6284798Abstract: The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing compounds, of formula (I), wherein wherein x is —NH—NH—CH2R1 and R1 denotes C8 to C20 alkyl.Type: GrantFiled: October 18, 1999Date of Patent: September 4, 2001Assignee: Cancer Research Ventures LimitedInventors: Eberhard Amtmann, Norbert Frank, Gerhard Sauer, Gerhard Schilling
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Patent number: 6211304Abstract: Novel mordants based upon a poly(alkylene oxide) backbone and either pendant phosphonium or quaternized-nitrogen compounds are disclosed. The mordants find use in stopping or controlling ink-bleeding in ink-jet receptors and photographic films.Type: GrantFiled: August 30, 1995Date of Patent: April 3, 2001Assignee: 3M Innovative Properties CompanyInventor: Omar Farooq
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Patent number: 6180676Abstract: This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and/or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.Type: GrantFiled: June 6, 1995Date of Patent: January 30, 2001Assignee: The Picower Institute for Medical ResearchInventors: Marina Bianchi, Anthony Cerami, Kevin J. Tracey, Peter Ulrich
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Patent number: 6136987Abstract: This invention relates to the use of arylguanidinium xanthogenates as vulcanization accelerators, to a process for the production thereof and to the arylguanidinium xanthogenates.Type: GrantFiled: October 25, 1999Date of Patent: October 24, 2000Assignee: Rhein Chemie Rheinau GmbHInventors: Thomas Fruh, Ludger Heiliger, Hermann Lohwasser
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Patent number: 6114392Abstract: The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia).The invention further provides novel compounds of general formula I (which are quinuclidine derivatives), formula II (which are norbornane derivatives), formula III (which are adamantane derivatives), and formula IV (which are phenothiazine derivatives): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, hydroxy, substituted or unsubstituted C.sub.1-4 alkyl, substituted or unsubstituted C.sub.1-4 alkoxy, halogeno, amino, phenyl, or R.sub.4 NR.sub.5 ; R.sub.4 and R.sub.5 are each independently hydrogen, or (CH.sub.2)n--[NH(CH.sub.2)x]y--NHR.sub.6, or (CH.sub.2)n--[NH(CH.sub.2)x]y--NH--NHR.sub.6, or (CH.sub.2)n--[NH(CH.sub.2)x]y--(NR.sub.7 .dbd.)CNHR.sub.6, or (CH.sub.2)n--[NH(CH.sub.2)x]y--NH(NR.sub.7 .dbd.)CNHR.sub.6 wherein n is from 0-5, y is from 0-5 and each x is independently from 1-5; R.Type: GrantFiled: April 16, 1996Date of Patent: September 5, 2000Inventors: Gad M. Gilad, Varda H. Gilad
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Patent number: 6063819Abstract: Neuroprotective drugs are disclosed with at least 3 branches extending outwardly from a center atom or group, each branch having a guanidino group at its terminus. All branches preferably should be identical, and distributed around the center atom or group in a radial manner. Three branches can be bonded to a nitrogen atom, or four branches can be coupled to a carbon atom; other center groups include stable aromatic, cycloalkyl, heterocyclic, or bicyclic structures. Starting reagents are disclosed with a center atom or group, and with reactive groups (such as primary amines or hydroxyl groups) at the ends of short "spacer chains" bonded to the center atom or group. Reagents derived from arginine (an amino acid having a terminal guanidino group) can be bonded to these center components, using protective groups on the arginyl reagents to ensure desired final products with accessible guanidino groups at the ends of spacer chains.Type: GrantFiled: February 18, 1998Date of Patent: May 16, 2000Assignee: Cypros Pharmaceutical Corp.Inventors: Paul J. Marangos, Brian W. Sullivan, Torsten Wiemann, Anne M. Danks, Marina Sragovicz, Lewis R. Makings
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Patent number: 5856571Abstract: Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are semicarbazide-containing linker compounds useful in forming conjugates having stable semicarbazone linkages. The stably-linked conjugates have utility in a variety of immunodiagnostic and separation techniques.Type: GrantFiled: June 7, 1995Date of Patent: January 5, 1999Assignee: CellPro, IncorporatedInventors: Ronald W. Berninger, Mark S. Lodge, Stanley Joseph Tarnowski, Jr.
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Patent number: 5852009Abstract: The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents may contain an active nitrogen-containing group, such as a hydrazine group. Particular agents comprise aminoguanidine, .alpha.-hydrazinohistidine and mixtures thereof. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.Type: GrantFiled: January 16, 1997Date of Patent: December 22, 1998Assignee: The Rockefeller UniversityInventors: Anthony Cerami, Peter C. Ulrich, Michael A. Brownlee
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Patent number: 5837737Abstract: Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: Cambridge NeuroScience, Inc.Inventors: Stanley M. Goldin, Subbarao Katragadda, Lain-Yen Hu, N. Laxma Reddy, James B. Fischer, Andrew Gannett Knapp, Lee David Margolin
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Patent number: 5753684Abstract: This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and/or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.Type: GrantFiled: June 6, 1995Date of Patent: May 19, 1998Assignee: The Picower Institute for Medical ResearchInventors: Marina Bianchi, Anthony Cerami, Kevin J. Tracey, Peter Ulrich
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Patent number: 5714617Abstract: A method for producing 3-amino-5-mercapto-1,2,4-triazole, useful as an intermediate compound for a medicine or pesticide, or the intermediate thereof, a salt of N-guanidino thiourea from aminoguanidine thiocyanate or a thiocyanate and an aminoguanidine compound in the presence of an acid in a polar solvent, or even from hydrazine and cyanamide is disclosed.Type: GrantFiled: March 1, 1996Date of Patent: February 3, 1998Assignee: Nippon Carbide Kogyo Kabushiki KaishaInventors: Takehiko Yoshie, Masanori Sasaki, Hiroshi Shibafuchi, Yasushi Imai, Masahiro Murotani, Kenichi Ishii, Hajime Mura
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Patent number: 5705531Abstract: 1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): ##STR1## where eitherthe symbol - - - - represents a single bond,the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, andA is (CH.dbd.CH).sub.m (CH.sub.2).sub.n OR, (CH.dbd.CH).sub.m (CH.sub.2).sub.n NR.sup.1 R.sup.2, (CH.dbd.CH).sub.m (CH.sub.2).sub.p B, OH, O(CH.sub.2).sub.q OR, O(CH.sub.2).sub.q NR.sup.1 R.sup.2 or O(CH.sub.2).sub.r B;q is an integer from 2 to 5;r is an integer from 1 to 2;orthe symbol - - - - represents a double bond,A is oxygen, CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n OR,CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n NR.sup.1 R.sup.2 orCH(CH.dbd.CH).sub.s (CH.sub.2).sub.p B; andL is ?CH.dbd.C(R.sup.3)!.sub.s CH.dbd.NR.sup.4 or ?CH.dbd.C(R.sup.3)!.sub.s CH.sub.2 NHR.sup.4, in the E configuration, are useful for treating cardiovascular disorders such as heart failure and hypertension.Type: GrantFiled: November 2, 1995Date of Patent: January 6, 1998Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Alberto Cerri, Nicoletta Almirante, Giuseppe Bianchi, Patrizia Ferrari, Piero Melloni
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Patent number: 5698563Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises bis(guanylhydrazone) of the formula ##STR1## capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.Type: GrantFiled: January 13, 1995Date of Patent: December 16, 1997Assignee: Alteon Inc.Inventors: Dilip R. Wagle, Michael E. Lankin, David H. Shih
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Patent number: 5693673Abstract: Process for the preparation of 2,2'-(1-methyl 1,2-ethanediylidene)bis?hydrazine carboximidamide! by:a) reacting aminoguanidine hydrochloride with methylglyoxal aldehyde or methylglyoxal dimethyl acetal; andb) purifying the 2,2'-(1-methyl-1,2-ethanediylidene)bis?hydrazine carboximidamide! by crystallization from an acidic aqueous-isopropyl alcohol medium.Type: GrantFiled: May 30, 1996Date of Patent: December 2, 1997Assignee: SanofiInventors: Richard Philion, Steven A. Elenbaas
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Patent number: 5659083Abstract: Process for the preparation of 2,2'-(1-methyl-1,2-ethanediylidine)bis[hydrazine carboximidamide] bya) removing impurities from aminoguanidine bicarbonate;b) reacting the aminoguanidine bicarbonate with methylglyoxal dimethyl acetal in an aqueous isopropyl medium; andc) purifying the 2,2'-(1-methyl-1,2-ethanediylidene)bis[hydrazine carboximidamide] by crystallization from an acidic aqueous-isopropanol medium.Type: GrantFiled: May 30, 1996Date of Patent: August 19, 1997Assignee: SanofiInventors: Richard Philion, Martin Robert Gray
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Patent number: 5639911Abstract: Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.Type: GrantFiled: June 7, 1995Date of Patent: June 17, 1997Assignee: Ciba-Geigy CorporationInventors: Jaroslav Stanek, Jorg Frei, Giorgio Caravatti
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Patent number: 5612332Abstract: The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or tri-aminoguanidine capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.Type: GrantFiled: June 7, 1995Date of Patent: March 18, 1997Assignees: Alteon Inc., The Rockefeller UniversityInventors: Dilip R. Wagle, Peter C. Ulrich, Anthony Cerami
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Patent number: 5599984Abstract: This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and/or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections.Type: GrantFiled: September 29, 1994Date of Patent: February 4, 1997Assignee: The Picower Institute For Medical ResearchInventors: Marina Bianchi, Anthony Cerami, Kevin J. Tracey, Peter Ulrich
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Patent number: 5559243Abstract: A method for producing 3-amino-5-mercapto-1,2,4-triazole, useful as an intermediate compound for a medicine or pesticide, or the intermediate thereof, a salt of N-guanidino thiourea from aminoguanidine thiocyanate or a thiocyanate and an aminoguanidine compound in the presence of an acid in a polar solvent, or even from hydrazine and cyanamide is disclosed.Type: GrantFiled: December 16, 1994Date of Patent: September 24, 1996Assignee: Nippon Carbide Kogyo Kabushiki KaishaInventors: Takehiko Yoshie, Masanori Sasaki, Hiroshi Shibafuchi, Yasushi Imai
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Patent number: 5494934Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 represents substituted or unsubstituted phenyl or (C.sub.3 -C.sub.7) cycloalkyl,R.sub.2 represents trifluoromethyl or (C.sub.3 -C.sub.4) cycloalkyl,A represents --CH.sub.2 --, --CH.dbd.N--, .dbd.N-- or --NH--,R.sub.3 and R.sub.4, which may be identical or different, represent hydrogen or linear or branched (C.sub.1 -C.sub.6) alkyl or, with the nitrogen atoms to which they are attached, form a 5- or 6-membered heterocycle,R represents either hydrogen in the case where A=--CH.sub.2 --, --CH.dbd.N-- or --NH--, or a bond of the group A when the latter is equal to .dbd.N--,its enantiomers and epimers as well as its addition salts with a pharmaceutically acceptable acid.Medicine products.Type: GrantFiled: November 4, 1991Date of Patent: February 27, 1996Assignee: Adir et CompagnieInventors: Charles Malen, Jean-Michel Lacoste, Guillaume de Nanteuil
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Patent number: 5478946Abstract: Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.Type: GrantFiled: November 30, 1993Date of Patent: December 26, 1995Assignee: Abbott LaboratoriesInventors: Ferid Murad, James F. Kerwin, Lee D. Gorsky
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Patent number: 5464858Abstract: Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of .alpha..sub.1 adrenergic agonists are physiologically active compounds including N.sup..delta. -substituted ornithine or N.sup..epsilon. -substituted lysine moieties or monoalkyl carbon-substituted N.sup..delta. -substituted ornithine or N.sup..epsilon. -substituted lysine moieties, having the formula ##STR1## wherein R is (CH.sub.2).sub.y CH.sub.3 or H, R' is CH.sub.2 or C(H)(CH.sub.2).sub.y CH.sub.3, and R" is CH.sub.2 or C(H)(CH.sub.2).sub.y CH.sub.3, with y ranging from 0 to 5, and x is 0 or 1 and wherein none or only one of R, R' and R" provides an alkyl substituent on ornithine or lysine moiety, and wherein Q is a heme binding moiety and/or a sulfur-containing binding moiety and Q' is --NH.sub.2 when there is a double bond between the omega carbon and Q and Q' is .dbd.Type: GrantFiled: December 12, 1994Date of Patent: November 7, 1995Assignee: The Medical College of Wisconsin Research Foundation, Inc.Inventors: Owen W. Griffith, Krishnaswamy Narayanan
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Patent number: 5461076Abstract: Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.Type: GrantFiled: November 30, 1994Date of Patent: October 24, 1995Inventors: Jaroslav Stanek, Jorg Frei, Giorgio Caravatti
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Patent number: 5444082Abstract: 3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular disorders, such as heart failure and hypertension, are disclosed.Type: GrantFiled: June 28, 1993Date of Patent: August 22, 1995Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Marco Frigerio, Patrizia Ferrari, Piero Melloni, Giuliana Salani
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Patent number: 5403955Abstract: Novel mordants based upon a polyethyleneimine backbone and either pendant phosphonium or quaternized-nitrogen compounds are disclosed. The mordants find use in stopping or controlling ink-bleeding into ink-jet receptors and photographic films.Type: GrantFiled: April 28, 1994Date of Patent: April 4, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventor: Omar Farooq
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Patent number: 5395855Abstract: Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.Type: GrantFiled: March 28, 1994Date of Patent: March 7, 1995Assignee: Ciba-Geigy CorporationInventors: Jaroslav Stanek, Jorg Frei, Giorgio Caravatti
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Patent number: 5380945Abstract: Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.Type: GrantFiled: November 30, 1993Date of Patent: January 10, 1995Assignee: Abbott LaboratoriesInventors: Ferid Murad, James F. Kerwin, Lee D. Gorsky
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Patent number: 5296498Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 represents substituted or unsubstituted phenyl or (C.sub.3 -C.sub.7) cycloalkyl,R.sub.2 represents trifluoromethyl or (C.sub.3 -C.sub.4) cycloalkyl,A represents --CH.sub.2 --, --CH.dbd.N--, .dbd.N-- or --NH--,R.sub.3 and R.sub.4, which may be identical or different, represent hydrogen or linear or branched (C.sub.1 -C.sub.6) alkyl or, with the nitrogen atoms to which they are attached, form a 5- or 6-membered heterocycle,R represents either hydrogen in the case where A=--CH.sub.2 --, --CH.dbd.N-- or --NH--, or a bond of the group A when the latter is equal to .dbd.N--,its enantiomers and epimers as well as its addition salts with a pharmaceutically acceptable acid.Type: GrantFiled: January 19, 1993Date of Patent: March 22, 1994Assignee: Adir et CompagnieInventors: Charles Malen, Jean-Michel Lacoste, Guillaume de Nanteuil
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Patent number: 5200541Abstract: The products having general formula (I) ##STR1## in which R represents a C.sub.1 -C.sub.18 alkoxyl, C.sub.1 -C.sub.18 alkylthio, C.sub.1 -C.sub.18 monoalkylamino or C.sub.2 -C.sub.36 dialkylamino group, R.sub.1 represents a hydrogen atom or a C.sub.1 -C.sub.18 alkyl group, R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom or a C.sub.1 -C.sub.18 alkoxyl group and M represents a cobalt, nickel or copper atom, process of preparation, intermediates and use of the intermediates in order to obtain a product having general formula (I).Type: GrantFiled: January 10, 1992Date of Patent: April 6, 1993Assignee: Societe Francaise HoechstInventor: Thierry Thami
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Patent number: 5087733Abstract: Processes for conditioning human hair by treatment with selected sulfur containing quaternary ammonium compounds, compositions useful for such processes and novel quaternary compounds useful in the processes.Type: GrantFiled: August 3, 1990Date of Patent: February 11, 1992Assignee: Clairol, Inc.Inventors: Thomas M. Deppert, Janusz Z. Jachowicz, Bryan P. Murphy
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Patent number: 5041661Abstract: A process for preparing triaminoguanidine nitrate from relatively impure -99 percent)/commercial guanidine nitrate and commercial grade aqueous hydrazine (50-64 weight percent) in alcohol by: (1) adding enough hydrazine to form monoaminoguanidine nitrate, diaminoguanidine nitrate, or mixtures thereof, (2) physically removing the alcohol insoluble, solid impurities from the solution, (3) adding the remainder of the hydrazine needed to form triaminoguanidine nitrate, (4) adding nitric acid to adjust the pH to from 4.5 to 5.5, and (6) isolating the product triaminoguanidine nitrate.Type: GrantFiled: July 2, 1984Date of Patent: August 20, 1991Assignee: The United States of America as represented by the Secretary of the NavyInventors: Kerry L. Wagaman, Chester F. Clark, Larry D. Henderson
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Patent number: 4906778Abstract: A process for the preparation of aminoguanidine bicarbonate includes reacting an acidic aqueous hydrazine hydrate solution with calcium cyanamide in an elevated temperature to produce an aminoguanidine solution, recovering the solution, and reacting therewith an alkali metal bicarbonate to produce relatively high purity aminoguanidine bicarbonate.Type: GrantFiled: August 29, 1988Date of Patent: March 6, 1990Assignee: Amoco CorporationInventor: John G. Schaffhausen
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Patent number: 4800232Abstract: A process for producing triaminoguanidine nitrate, and, more specifically, a process which involves reacting hydrazine, nitric acid and cyanamide in specified molar ratios. Also claimed is the high melting point product so produced.Type: GrantFiled: October 16, 1987Date of Patent: January 24, 1989Assignee: Olin CorporationInventors: Eugene F. Rothgery, Steven A. Manke
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Patent number: 4743595Abstract: A process for efficiently preparing 2-amino-5-nitrophenol derivatives in which benzoxazole derivatives are subjected to nucleophilic substitution reaction at the 5 position thereof to obtain corresponding benzoxazole derivatives, and the oxazole ring of the benzoxazole derivatives is then subjected to ring-opening to obtain 2-amino-5-nitrophenol derivatives. The 2-amino-5-nitrophenol derivatives are useful as industrial starting materials, reducing agents or antioxidants and intermediates for cyan-image-forming couplers.Type: GrantFiled: June 12, 1985Date of Patent: May 10, 1988Assignee: Fuji Photo Film Co., Ltd.Inventors: Isamu Itoh, Mitsunori Ono, Hidetoshi Kobayashi, Kazuyoshi Yamakawa