Acyclic Patents (Class 564/268)
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Publication number: 20140316149Abstract: This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex; (b) a copper complex; (c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde.Type: ApplicationFiled: April 17, 2014Publication date: October 23, 2014Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: ZACHARY K. WICKENS, BILL MORANDI, ROBERT H. GRUBBS, KACPER SKAKUJ, SARAH BRONNER
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Publication number: 20140179951Abstract: A method for producing a ketoxime is provided. The method includes the step of performing a reaction of a nitrogen-containing compound, ketone and an oxidant by using a titanium-silicon molecular sieve as a catalyst, so as to form the ketoxime, thereby increasing the yield and selectivity of the ketoxime.Type: ApplicationFiled: November 22, 2013Publication date: June 26, 2014Applicant: China Petrochemical Development Corporation, Taipei (Taiwan)Inventors: Shih-Yao Chao, Cheng-Fa Hsieh, Chien-Chang Chiang, Pin-To Yao
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Patent number: 8735594Abstract: The present invention is directed towards proposing ligands of formula: and is also directed towards a substrate at the surface of which is immobilized at least one unit of formula:Type: GrantFiled: April 20, 2011Date of Patent: May 27, 2014Assignee: Commissariat a l'Energie Atomique et Aux Energies AlternativesInventors: Pierre-Andre Jacques, Vincent Artero, Marc Fontecave, Adeline Leyris, Muriel Matheron
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Publication number: 20130267604Abstract: Provided are protected antimicrobial compounds which are useful for controlling microorganisms in aqueous or water-containing systems, such as oil or gas field fluids, at elevated temperature. The antimicrobial compounds are of the formula I: wherein R3 and R4 are as defined herein.Type: ApplicationFiled: November 29, 2011Publication date: October 10, 2013Applicants: DOW GLOBAL TECHNOLOGIES LLC, ANGUS CHEMICAL COMPANYInventors: Charles E. Coburn, Michael V. Enzien, Heather R. Mcginley, David W. Moore
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Publication number: 20130184494Abstract: According to the first embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield and high productivity by oxidizing the hydrocarbon compound with molecular oxygen in the co-presence of an N-hydroxy compound, such as methyl ethyl ketone or N-hydroxysuccinimide, and a phosphate ester, such as dibutyl phosphate. According to another embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield by using an oxidation catalyst that comprises an oxime compound, such as methyl ethyl ketone. According to another embodiment of the present invention, an alcohol and/or a ketone can be produced with high yield by oxidizing the hydrocarbon compound at a temperature of 160° C. or less, and by decomposing the resulting hydroperoxide, for example, in a unit having an inner surface formed by a material from which no transition metal ion is generated.Type: ApplicationFiled: September 26, 2011Publication date: July 18, 2013Applicant: USE Industries, Ltd.Inventors: Kazunori Kurosawa, Joji Funatsu, Naoya Katagiri, Junichi Kugimoto
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Publication number: 20130066112Abstract: The invention relates to multi-amine functional oligomers and multi-oxime functional oligomers in addition to a method for producing the same by means of the co-polymerisation of carbonyl carriers such as olefins or dienes, reaction with hydroxylamine and a subsequent selective catalytic hydrogenation.Type: ApplicationFiled: March 8, 2011Publication date: March 14, 2013Applicant: Bayer Intellectual Property GmbHInventors: Christoph Gürtler, Thomas Ernst Müller, Ewa Gebauer, Henning Vogt, Yevgen Berezhanskyy, Burkhard Köhler, Walter Leitner
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Publication number: 20110293553Abstract: Compounds, compositions, kits, devices, and methods of attracting, detecting, eradicating, controlling, or killing an insect, such as a bed bug, by utilizing insect attractant, arresting, and/or aggregation compounds and compositions is provided. Insect attractant, arresting, and/or aggregation compounds identified from insect fecal extract by an analytical technique, such as gas chromatography, nuclear magnetic resonance (NMR), Carbon-13 NMR, mass spectroscopy, LC-MS, GC-MS, high performance liquid chromatography (HPLC), or combinations thereof are provided. A bed bug attractant, arresting, and/or aggregation compound identified from bed bug feces and exhibiting a Carbon-13 NMR peak at about ? 159.453 ppm is also provided.Type: ApplicationFiled: May 28, 2010Publication date: December 1, 2011Inventors: Tai-Teh Wu, Kenneth Haynes, Joe Harold Hope, III
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Publication number: 20110257406Abstract: The present invention is directed towards proposing ligands of formula: and is also directed towards a substrate at the surface of which is immobilized at least one unit of formula:Type: ApplicationFiled: April 20, 2011Publication date: October 20, 2011Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Pierre-Andre JACQUES, Vincent ARTERO, Marc FONTECAVE, Adeline LEYRIS, Muriel MATHERON
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Publication number: 20110190539Abstract: The present disclosure pertains to a process for preparing an oxime in which a carbonyl compound is reacted in the liquid phase with NH3 and H2O2 in the presence of a catalyst to form the corresponding oxime, wherein the catalyst comprises a catalytic component selected from the oxides of metals of group 5 and group 6. The use of a niobia catalyst is particularly preferred. The process according to the disclosure is suitable for the manufacture of numerous oximes, in particular cyclohexanone oxime.Type: ApplicationFiled: February 4, 2010Publication date: August 4, 2011Applicant: Universiteit Van AmsterdamInventor: Nirappurackal Raveendran Shiju
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Patent number: 7985403Abstract: The present invention relates to the field of perfumery. More particularly, it concerns specific oxime or nitrite derivatives of 4-dodecene, which are useful perfuming ingredients in particular to impart natural mandarin odor notes.Type: GrantFiled: March 25, 2008Date of Patent: July 26, 2011Assignee: Firmenich SAInventors: Jean-Marc Gaudin, Wessel-Jan Kos
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Publication number: 20100069670Abstract: An oxidation catalyst for use in the oxidation of a substrate with a molecular oxygen, comprising at least one member selected from the group consisting of a specific hydrazyl radical (such as 2,2-diphenyl-1-picrylhydrazyl) and a specific hydrazine compound (such as 2,2-diphenyl-1-picrylhydrazine). A method for producing a chemical compound, comprising contacting a substrate with a molecular oxygen in the presence of the above-mentioned oxidation catalyst.Type: ApplicationFiled: November 13, 2009Publication date: March 18, 2010Applicant: ASAHI KASEI CHEMICALS CORPORATIONInventor: Ken Suzuki
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Publication number: 20100040542Abstract: The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal 99mTc, are useful as radiopharmaceuticals.Type: ApplicationFiled: October 1, 2009Publication date: February 18, 2010Applicant: GE HEALTHCARE LIMITEDInventors: COLIN MILL ARCHER, HARRY JOHN WADSWORTH, TORGRIM ENGELL
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Publication number: 20100008881Abstract: The present invention relates to the field of perfumery. More particularly, it concerns specific oxime or nitrite derivatives of 4-dodecene, which are useful perfuming ingredients in particular to impart natural mandarin odor notes.Type: ApplicationFiled: March 25, 2008Publication date: January 14, 2010Inventors: Jean-Marc Gaudin, Wessel-Jan Kos
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Publication number: 20090137191Abstract: The present invention relates to methods of using amidoxime compositions for cleaning polishing pads, particularly after chemical mechanical planarization or polishing is provided. A polishing pad is cleaned of Cu CMP by-products, subsequent to or during planarizing a wafer, to reduce pad-glazing by applying to the polishing pad surface a composition comprising an aqueous amidoxime compound solution in water.Type: ApplicationFiled: October 29, 2008Publication date: May 28, 2009Inventor: Wai Mun Lee
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Publication number: 20090111965Abstract: The present application relates to semiconductor processing compositions comprising at least one compound containing at least one amidoxime functional group and to methods of using these compositions in semiconductor processing. The present application also describes the preparation of amidoximes for a semiconductor processing composition by (a) mixing a cyanoethylation catalyst, a nucleophile and an alpha-unsaturated nitrile to produce a cyanoethylation product; and (b) converting a cyano group in the cyanoethylation product into an amidoxime functional group.Type: ApplicationFiled: October 29, 2008Publication date: April 30, 2009Inventor: Wai Mun Lee
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Patent number: 7164042Abstract: The invention concerns a production method which consists in forming a reaction medium containing 2,2,4,4,-tetramethyl-3-pentanone, hydrogen peroxide, ammonia and a zeolitic structure catalyst and allowing the reaction to obtain said oxime. 2,2,4,4,-tetramethyl-3-pentanone and hydrogen peroxide can be obtained by auto-oxidation of 2,2,4,4,-tetramethyl-3-pentanol with oxygen or air. Hydroxylammonium salts are obtained by acid hydrolysis of said oxime.Type: GrantFiled: May 22, 2002Date of Patent: January 16, 2007Assignee: Fluorotech, LLCInventor: Jean-Pierre Schirmann
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Patent number: 6849570Abstract: The present invention relates to a process for the production of a titanium silicalite shaped body by: (a) forming a formable composition containing titanium silicalite, a binder and a pasting agent, so that the Curd curve of the formable composition has a plateau value in the range from 20 to 90 mm; (b) shaping the composition of step (a) to form a green body; (c) optionally drying and (d) calcining the green body, to a titanium silicalite shaped body obtainable by that process, and to the use of such titanium silicalite shaped bodies in the epoxidation of olefins or the ammoximation of ketones.Type: GrantFiled: March 21, 2001Date of Patent: February 1, 2005Assignee: Degussa AGInventors: Steffen Hasenzahl, Ralf Jantke
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Publication number: 20040258619Abstract: The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal99mTc, are useful as radiopharmaceuticals.Type: ApplicationFiled: June 21, 2004Publication date: December 23, 2004Inventors: Colin Mill Archer, Harry John Wadsworth, Torgrim Engell
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Patent number: 6703182Abstract: Compounds of formulae I, II or III wherein m is zero or 1; n is 1, 2 or 3; R1 inter alia is unsubstituted or substituted phenyl, or naphthyl, anthracyl, phenanthryl, a heteroaryl radical, or C2-C12alkenyl; R′1 inter alia is vinylene, phenylene, naphthylene, diphenylene or oxydiphenylene; R2 inter alia is CN, C1-C4haloalkyl, C2-C6alkoxycarbonyl, phenoxycarbonyl, or benzoyl; R3 inter alia is C1-C18alkylsulfonyl, phenyl-C1-C3alkylsulfonyl, camphorylsulfonyl, or phenylsulfonyl; R′3 inter alia is C2-C12alkylenedisulfonyl, phenylenedisulfonyl, naphthylenedisulfonyl, diphenylenedisulfonyl, or oxydiphenylenedisulfonyl; R4 and R5 inter alia are hydrogen, halogen, C1-C8alkyl, C1-C6alkoxy, C1-C4haloalkyl, CN, NO2, C2-C6alkanoyl, benzoyl, phenyl, —S-phenyl, OR6, SR9, NR7R8, C2-C6alkoxycarbonyl or phenoxycarbonyl; R6 inter alia is hydrogen, phenyl or C1-C12alkyl; R7 and R8 inter alia are hydrogen or C1-C12alkyl; R9 inter alia is C1-C12 alkyl; R10, R11 andType: GrantFiled: February 15, 2001Date of Patent: March 9, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Luc Birbaum, Toshikage Asakura, Hitoshi Yamato
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Patent number: 6207863Abstract: Disclosed is an improved method for the preparation of highly pure haloformimine compounds in high yields by reacting a formimine compound in a solvent with a halogenating agent while maintaining the pH of the halogenation reaction in the range of 2 to 5. The pH of the reaction may be maintained by a variety of means, such as by the addition of a base.Type: GrantFiled: May 25, 1999Date of Patent: March 27, 2001Assignee: Rohm and Haas CompanyInventors: John Vincent Berrier, Ashutosh Sumantrai Umarvadia
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Patent number: 6037378Abstract: Phenylacetic acid derivatives of the formula I ##STR1## where the substituents and the index have the following meanings: X is NOCH.sub.3, CHOCH.sub.3, CHCH.sub.3 ;Y is O, NRR.sup.1,R independently of one another are hydrogen and C.sub.1 -C.sub.4 -alkyl;R.sup.2 is cyano, nitro, trifluoromethyl, halogen, alkyl and alkoxy;m is 0, 1 or 2, it being possible for the radicals R.sup.2 to be different when m is 2;R.sup.3 is hydrogen, cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.3 -C.sub.6 -cycloalkyl;R.sup.4, R.sup.5 and R.sup.6 have the meanings given in claim 1,and their salts, a process and intermediates for the preparation of these compounds, and compositions comprising them for controlling animal pests and harmful fungi.Type: GrantFiled: January 14, 1999Date of Patent: March 14, 2000Assignee: BASF AktiengesellschaftInventors: Thomas Grote, Herbert Bayer, Ruth Muller, Hubert Sauter, Reinhard Kirstgen, Volker Harries, Gisela Lorenz, Eberhard Ammermann, Siegfried Strathmann
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Patent number: 5808091Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comnprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.Type: GrantFiled: April 3, 1995Date of Patent: September 15, 1998Assignee: Bracco International B.V.Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
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Patent number: 5741912Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: April 21, 1998Assignee: Bracco International B.V.Inventors: Kondareddiar Ramalingam, Natarajan Raju
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Patent number: 5731462Abstract: The subject of the present invention is a new process for obtaining nitrones. It more particularly relates to a process for obtaining N-monosubstituted hydroxylamine comprising a stage in which a nitrone is formed from a secondary amine in the presence of an oxidizing agent and of at least one C.dbd.O containing species chosen from the group consisting of carbon dioxide, hydrogencarbonates and carbonates.Type: GrantFiled: December 18, 1996Date of Patent: March 24, 1998Assignee: Elf Atochem S.A.Inventors: Christophe Calais, Remy Teissier
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Patent number: 5684201Abstract: Aliphatic or cycloaliphatic oximes are prepared by treating aliphatic or cycloaliphatic imines with oxygen or with an oxygen-containing gas in the presence of a catalyst.Type: GrantFiled: June 20, 1995Date of Patent: November 4, 1997Assignee: BASF AktiengesellschaftInventors: Norbert Rieber, Peter Lingelbach, Tom Witzel, Ulrich Muller
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Patent number: 5665329Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: September 9, 1997Assignee: Bracco International B.V.Inventors: Kondareddiar Ramalingam, Natarajan Raju
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Patent number: 5656254Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: August 12, 1997Assignee: Bracco International B.V.Inventors: Kondareddiar Ramalingam, Natarajan Raju
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Patent number: 5627286Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: May 6, 1997Assignee: Bracco International B.V.Inventors: Kondareddiar Ramalingam, Natarajan Raju
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Patent number: 5608110Abstract: Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.Type: GrantFiled: May 18, 1994Date of Patent: March 4, 1997Assignee: Bracco International B.V.Inventors: Kondareddiar Ramalingam, Natarajan Raju
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Patent number: 5495023Abstract: A new nitro compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each lower alkyl or lower alkoxy(lower)alkyl, or ##STR2## is cyclized to form ##STR3## X is --O--, --S-- or --NH--, m is an integer 0 or 1, andR.sup.3 is carbamoyl, lower alkylcarbamoyl, lower alkanoyl, di-lower alkylaminosulfonyl, lower alkylsulfonyl, oxamoyl or a group of the formula: --(Y).sub.n --R.sup.4whereinY is --CO--, --SO.sub.2 --, --COCH.sub.2 -- or ##STR4## n is an integer of 0 or 1, and R.sup.4 is heterocyclic group which is optionally substituted with one or more substituents selected from lower alkyl, lower alkoxy, phenyl, carbamoyl, halogen, amino, lower alkylthio, hydroxy, lower alkylsulfonylamino and carbamoylmethyl, and pharmaceutically acceptable salt thereof, which are useful as vasodilators.Type: GrantFiled: May 3, 1994Date of Patent: February 27, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masayuki Kato, Shigetaka Nishino, Mitsuko Hamano, Hisashi Takasugi
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Patent number: 5476967Abstract: An organic solvent solution of glyoxime and a chlorinating agent are simultaneously charged into a reaction vessel to produce an organic solvent solution of dichloroglyoxime in a stable form, simply and in a high yield. Dichloroglyoxime is used as an industrial antibacterial agent, an antiseptic, a slime control agent, an agricultural chemical, and the like.Type: GrantFiled: July 27, 1994Date of Patent: December 19, 1995Assignee: Junsei Chemical Co., Ltd.Inventors: Hideki Kanno, Hideki Yamamoto
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Patent number: 5434307Abstract: A process for producing 12-oxododecanoic acid oxime, a novel compound which can be used as a raw material in several industrial processes, is disclosed. The disclosed process relies on a renewable raw material, vernolic (cis-12,13-epoxy-cis-9-octadecenoic) acid. The process utilizes readily available chemical technology which does not involve the use of gaseous hydrocarbon or petrochemical-base feedstock. Hydrogenation of vernolic acid produces 12,13-epoxystearic acid, which can be oxidized with periodic acid to give 12-oxododecanoic acid, which can be reacted with hydroxylamine to yield 12-oxododecanoic acid oxime. A process for reducing the 12-oxododecanoic acid oxime to yield 12-aminododecanoic acid, the monomer for nylon-12, is also disclosed.Type: GrantFiled: May 21, 1993Date of Patent: July 18, 1995Assignee: Howard UniversityInventors: Chukwuma P. Nwaonicha, Folahan O. Ayorinde
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Patent number: 5387692Abstract: Agents for the diagnosis or treatment of hypoxic cells comprise a bioreductive moiety such as 2-nitroimidazole, and a metal chelating moiety which is a bis-amine oxime of which a carbon atom adjacent a nitrogen atom is linked to the bioreductive moiety. A chelated metal atom or ion preferably Technetium-99m. The agent diffuses into cells where the 2-nitroimidazole is reduced thus trapping the chelated metal in the cell.Type: GrantFiled: June 16, 1992Date of Patent: February 7, 1995Assignee: Amersham International plcInventors: Anthony L. Riley, James D. Kelly
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Patent number: 5312987Abstract: Two-step process in the liquid phase for producing oximes at 60.degree.-100.degree. C. and 1.5-5 bars, which comprises:(a) in a primary step, ammoximating a carbonylic compound with H.sub.2 O.sub.2 and NH.sub.3 in the presence of a silicon, titanium and oxygen based catalyst;(b) oximating the residual carbonylic compound with a solution of hydroxylamine, obtained in its turn by oxidizing ammonia with H.sub.2 O.sub.2, having a concentration comprised within the range of from 0.01 to 3%, preferably of from 0.5 to 2% by weight, in such a way as to have a molar ratio of hydroxylamine to the carbonylic compound comprised within the range of from 0.9 to 3, preferably of from 1 to 2.Type: GrantFiled: March 30, 1993Date of Patent: May 17, 1994Assignee: Enichem Anic S.r.l.Inventors: Maria A. Mantegazza, Guido Petrini, Alberto Cesana
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Patent number: 5300690Abstract: A polyoxime can be formed by reacting hydroxylamine with a copolymer of carbon monoxide and propylene. When the relative amount of oxime units in the polyoxime is high the polyoxime is soluble in water. Conversely, solubility in organic solvent is conferred when the oxime content is relatively low.Type: GrantFiled: October 14, 1992Date of Patent: April 5, 1994Assignee: Akzo N.V.Inventor: Gurudas D. Sinai-Zingde
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Patent number: 5296433Abstract: Tris(pentafluorophenyl)borane complexes having the general formula (C.sub.6 F.sub.5).sub.3 B.(YXH).sub.q wherein X is oxygen, or sulfur; q is 1 to 3; Y is a hydrogen atom, R.sup.1 --, (R.sup.2).sub.3 Si--, or (R.sup.3 ).sub.2 C.dbd.N--; R.sup.1 is a hydrocarbyl group containing 1 to 500 carbon atoms, and may contain a divalent oxygen and further may be a fluorine-containing hydrocarbyl group; R.sup.2 is independently a linear or branched alkyl group containing 1 to 25 carbon atoms, or a phenyl group, further R.sup.2 may contain a SiO-- group; and R.sup.3 is independently a hydrocarbyl group containing 1 to 25 carbon atoms, R.sup.3 may be a hydrogen atom provided both R.sup.3 groups selected are not hydrogen atoms; and to complexes containing the borane complexes with an organometallic compound, either as a neutral compound or as an acidic salt that are useful as catalysts for polymerization and copolymerization of olefins and to polymeric products prepared using these catalysts.Type: GrantFiled: April 14, 1992Date of Patent: March 22, 1994Assignee: Minnesota Mining and Manufacturing CompanyInventors: Allen R. Siedle, William M. Lamanna
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Patent number: 5266726Abstract: Sterically hindered oximes provide polyolefin compositions, including those also containing a phenolic antioxidant, with improved resistance to discoloration during processing at elevated temperatures.Type: GrantFiled: May 8, 1992Date of Patent: November 30, 1993Assignee: Ciba-Geigy CorporationInventors: Stephen D. Pastor, Paul A. Odorisio
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Patent number: 5227525Abstract: A multistep process for the liquid phase ammoximation of carbonyl compounds with H.sub.2 O.sub.2 and NH.sub.3, at 60.degree.-100.degree. C., at 1.5-5 bar and in the presence of a catalyst based on silicon, titanium and oxygen, characterized in that:a) in one or more primary steps, the H.sub.2 O.sub.2 : carbonyl compound molar ratio ranges from 0.9 to 1.15 by mols and the carbonyl component conversion is carried out up to at least 95%;b) in a last (exhaustion) step the H.sub.2 O.sub.2 : carbonyl compound ratio is in a higher range, i.e. from 1.5 to 3.0 by mols.Type: GrantFiled: January 21, 1992Date of Patent: July 13, 1993Assignee: Enichem Anic s.r.l.Inventors: Sergio Tonti, Paolo Roffia, Vittorio Gervasutti
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Patent number: 5202456Abstract: The invention features a compound of the formulaW-Y-Q-Z or W-Y-ZwhereinW is a farnesyl group, a geranylgeranyl group, a substituted farnesyl group or a substituted geranylgeranyl group; ##STR1## wherein n=1, 2, 3, 4, 5, or 6; each of T.sub.1' . . . T.sub.n' and T.sub.1" . . . T.sub.n" is independently: Fl, Br, --NHCOCH.sub.3, --NH.sub.2, a peptide, an alkane group, an alkene group, an polyethyleneglycol group, a saturated fatty acid, an unsaturated fatty acid, a monosaccharide, or a disaccharide; andZ is --COOH or salts or esters thereof, --CONH.sub.2, --NO.sub.2, --PO.sub.3 or salts or esters thereof, --C N, or --SO.sub.3 or salts or esters thereof, provided that when W is farnesyl, Y is --S--, n=2, and either T.sub.2' or T.sub.2" is --NHCOCH.sub.3, then Z is not --COOH.The compounds of the invention are capable of interfering with enzymatic methylation of a peptide having the carboxyl-terminal motif --CAAX wherein C=cysteine, A=aliphatic amino acid, and X=any amino acid.Type: GrantFiled: April 15, 1991Date of Patent: April 13, 1993Assignee: The President and Fellows of Harvard CollegeInventor: Robert R. Rando
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Patent number: 5130486Abstract: Isomerization of an unsymmetrical ketoxime ether is effected using at least one Lewis acid selected from titanium chloride, titanium bromide, aluminum chloride, aluminum bromide, boron chloride, and boron bromide as isomerizing agents. Examples of the Lewis acid are titanium tetrachloride, titanium trichloride, aluminum trichloride, aluminum tribromide, boron trichloride, and boron tribromide. The ketoxime ether is preferably an anti-isomer or a syn-isomer of a compound represented by the formula (I) or a mixture of the anti-isomer and the syn-isomer: ##STR1## wherein R.sub.1 represents an aryl group, an aralkyl group or an alkyl group and R.sub.2 and R.sub.3 each represents an aralkyl group or an alkyl group, with a proviso that R.sub.1 and R.sub.2 are not identical.Type: GrantFiled: December 27, 1990Date of Patent: July 14, 1992Assignee: Sumitomo Chemical Company LimitedInventors: Naoto Konyo, Yukio Yoneyoshi, Gohfu Suzukamo
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Patent number: 5082947Abstract: A novel compound useful as an intermediate for synthesizing pesticides and medicine of the formula: ##STR1## in which: R is perfluoroalkyl, R.sup.1 is hydrogen, alkyl or optionally substituted phenyl, or a salt thereof.Type: GrantFiled: June 19, 1990Date of Patent: January 21, 1992Assignee: Shionogi & Co., Ltd.Inventors: Shinzaburo Sumimoto, Ichiro Ishizuka, Shiro Ueda, Hiroyuki Kai
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Patent number: 5066641Abstract: Described is 3,5,5-trimethylhexanal oxime defined according to the structure: ##STR1## and organoleptic uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles including but not limited to solid or liquid anionic, cathionic, nonionic and zwitterionic detergents, perfume polymers, fabric softener compositions, fabic softener articles, cosmetic powders and hair preparations.Type: GrantFiled: September 27, 1990Date of Patent: November 19, 1991Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, John J. De Virgilio, Jan T. Van Elst
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Patent number: 5041652Abstract: The present invention relates to a method of preparing a catalyst for the ammoximation of carboxylic compounds, consisting of a synthetic, crystaline and porous material based on silicon and titanium oxides, characterized in that a preformed matrix of amorphous silica is impregnated with an aqueous solution, containing a titanium compound and an organic compound of nitrogen, as a templating agent, and that to the thus impregnated material a zeolitic structure is given by means of a hydrothermal synthesis of usual type, shape and size of the matrix being substantially maintained unchanged.Type: GrantFiled: September 17, 1990Date of Patent: August 20, 1991Assignee: Montedipe S.p.A.Inventors: Mario Padovan, Giordano De Alberti, Paolo Roffia
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Patent number: 5026911Abstract: The invention relates to a process for preparing oximes starting from saturated primary (cyclo)aliphatic amines optionally substituted by groups which are inert under the reaction conditions, by reacting the saturated primary amine with oxygen, the reaction being conducted in the liquid phase in the presence of at least a catalyst based on compounds belonging to Group IV B of the Periodic System, thereby obtaining the corresponding aliphatic and cycloaliphatic oximes.Type: GrantFiled: April 25, 1990Date of Patent: June 25, 1991Assignee: Istituto Guido Donegani S.p.A.Inventors: Carlo Venturello, Rino D'Aloisio
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Patent number: 4968842Abstract: The invention concerns a catalytic process for the manufacture of oximes by ammoximation of the corresponding carbonyl compounds, characterized in that the catalyst is a solid composition consisting of silicon, titanium and oxygen, chemically combined with each other, and in that the titanium amount, expressed as TiO.sub.2, ranges from 1 to 95% by weight, the XR diffractogam of said composition being a smooth-trend line (halo), typical of the amorphous solids.Type: GrantFiled: September 15, 1989Date of Patent: November 6, 1990Assignee: Montedipe, S.p.A.Inventors: Mario Padovan, Fausto Genoni, Giuseppe Leofanti, Guido Petrini, Paolo Roffia, Alberto Cesana
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Patent number: 4929756Abstract: A process for preparing an oxime, which comprises reacting a ketone or an aldehyde with nitrogen monoxide and hydrogen in the presence of a platinum group metal catalyst to form the corresponding oxime.Type: GrantFiled: June 1, 1989Date of Patent: May 29, 1990Assignee: Mitsubishi Kasei CorporationInventor: Kiyoji Kuma
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Patent number: 4906768Abstract: A process for producing an oxime derivative, which comprises protecting the hydroxyimino group of an oxime compound with a protecting agent, subjecting the protected oxime compound to a given reaction, and thereafter deprotecting the reaction product, wherein a 2-alkenylating agent is used as the protecting agent.Type: GrantFiled: February 11, 1988Date of Patent: March 6, 1990Assignee: Nippon Zeon Co., Ltd.Inventors: Toshiro Yamada, Jiro Tsuji, Kuniaki Goto
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Patent number: 4894478Abstract: The invention relates to a process of producing ketoximes, characterized in that a secondary alcohol, corresponding to the desired ketoxime, is partially oxidated in the liquid phase with O.sub.2, an oxidated mixture being thereby formed, which contains an excess of unreacted alcohol, the ketone corresponding to said alcohol, and H.sub.2 O.sub.2, and that said oxidated mixture is directly reacted with NH.sub.3 in the liquid phase (without isolating the alcohol, the ketone and H.sub.2 O.sub.2) in the presence of an ammoximation catalyst.Type: GrantFiled: July 25, 1988Date of Patent: January 16, 1990Assignee: Montedipe S.p.A.Inventors: Paolo Roffia, Giuseppe Paparatto, Alberto Cesana, Giorgio Tauszik
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Patent number: 4827004Abstract: Novel Isoprene Derivatives which have mucosa-protective and gastric acid secretion-inhibiting properties and are useful for combatting ulcers both by treating and as a prophylaxis against gastric and/or duodenal ulcers.Type: GrantFiled: August 24, 1987Date of Patent: May 2, 1989Assignee: Hoffmann-La Roche Inc.Inventors: Albert Fischli, Max Schmid, Rudolf Schmid
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Patent number: 4794198Abstract: The invention concerns a catalytic process for the manufacture of oximes by reaction, in the liquid phase, of the corresponding carbonylic compounds with NH.sub.3 and H.sub.2 O.sub.2, in which process the catalyst is substantially consisting of a crystalline material with a zeolitic structure containing silicon and titanium, subjected, before use, to an activating treatment with H.sub.2 O.sub.2.Type: GrantFiled: June 8, 1987Date of Patent: December 27, 1988Assignee: Montedipe S.p.A.Inventors: Paolo Roffia, Mario Padovan, Giuseppe Leofanti, Maria A. Mantegazza, Giordano De Alberti, Giorgio R. Tauszik