Oximes (hch=n-oh, I.e., Wherein Substitution May Be Made For Hydrogen Only) Patents (Class 564/253)
  • Patent number: 11174368
    Abstract: An oxygen absorbing agent containing a compound (A) of formula (I): wherein X is a chalcogen atom, R1 and R2 are each any one of an alkyl group which optionally has a substituent, an alkenyl group which optionally has a substituent, an aryl group which optionally has a substituent, and an aralkyl group which optionally has a substituent, R3 and R4 are each any one of a hydrogen atom, an alkyl group which optionally has a substituent, an alkenyl group which optionally has a substituent, an aryl group which optionally has a substituent, and an aralkyl group which optionally has a substituent, and R5 is a polymerizable group; and a transition metal salt (B).
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: November 16, 2021
    Assignee: KURARAY CO., LTD.
    Inventors: Daiki Noguchi, Akinobu Takeda, Takashi Fukumoto
  • Patent number: 9708242
    Abstract: A method of manufacturing nitrone compounds is provided. The method includes: providing a nitro compound; and performing a photoreaction of the nitro compound, a catalyst and an additive under visible light to obtain the nitrone compound.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: July 18, 2017
    Assignee: National Chung Cheng University
    Inventors: Bor-Cherng Hong, Cheng-Wei Lin
  • Patent number: 8580799
    Abstract: The present invention relates to hydroximoyl-heterocycle derivatives of formula (I) wherein T represents a substituted or non-substituted heterocyclyl group, Q represents a carbo or heterocyclic group, A represent a carbo or heterocyclic group or a carbo or hetero-polycylic group, and L1 represents various linking groups, their process of preparation, intermediate compounds for their preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: November 12, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Christian Beier, Jurgen Benting, David Bernier, Pierre-Yves Coqueron, Philippe Desbordes, Christophe Dubost, Stephanie Gary, Pierre Genix, Daniela Portz, Ulrike Wachendorff-Neumann
  • Patent number: 8575391
    Abstract: An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application].
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: November 5, 2013
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshiaki Isshiki, Yasunori Kohchi, Eisaku Mizuguchi, Hitoshi Iikura, Yasuaki Matsubara, Shinji Tsujii, Nobuo Shimma, Masanori Miwa, Satoshi Aida, Masami Kohchi, Takeshi Murata, Kosuke Aso
  • Patent number: 8507726
    Abstract: Photoinitiators mixture comprising (i) at least one compound selected from the group consisting of alpha-hydroxy ketones, monoacylphosphine oxides, bisacylphosphine oxides, ketosulfones, benzil ketals, benzoin ether, phenylglyoxylates, borates and titanocenes; and (ii) at least one compound of the formula (I) or (I?) R1, R?1, R2 and R2? R?9 independently of each other for example are hydrogen or C1-C12alkyl R7, R8, R9, R?8 and R?9 independently of each other for example are hydrogen, C1-C12alkyl which optionally is substituted or phenyl which optionally is substituted, exhibit excellent photoinitiating properties.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: August 13, 2013
    Assignee: BASF SE
    Inventors: Katia Studer, Sébastien Villeneuve, Akira Matsumoto, Hisatoshi Kura, Jan Sültemeyer
  • Patent number: 8507725
    Abstract: Compounds of the formula I or (I?), wherein R1 and R?1 for example are hydrogen, C3-C8cycloalkyl or C1-C12alkyl, R2 and R2? for example are hydrogen; unsubstituted C1-C20alkyl or substituted C1-C20alkyl; and R8 and R9 for example are hydrogen, C1-C12alkyl which optionally is substituted, or phenyl which optionally is substituted; exhibit an unexpectedly good performance in photopolymerization reactions.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: August 13, 2013
    Assignee: BASF SE
    Inventors: Akira Matsumoto, Hisatoshi Kura
  • Publication number: 20130184494
    Abstract: According to the first embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield and high productivity by oxidizing the hydrocarbon compound with molecular oxygen in the co-presence of an N-hydroxy compound, such as methyl ethyl ketone or N-hydroxysuccinimide, and a phosphate ester, such as dibutyl phosphate. According to another embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield by using an oxidation catalyst that comprises an oxime compound, such as methyl ethyl ketone. According to another embodiment of the present invention, an alcohol and/or a ketone can be produced with high yield by oxidizing the hydrocarbon compound at a temperature of 160° C. or less, and by decomposing the resulting hydroperoxide, for example, in a unit having an inner surface formed by a material from which no transition metal ion is generated.
    Type: Application
    Filed: September 26, 2011
    Publication date: July 18, 2013
    Applicant: USE Industries, Ltd.
    Inventors: Kazunori Kurosawa, Joji Funatsu, Naoya Katagiri, Junichi Kugimoto
  • Publication number: 20130035278
    Abstract: The present invention relates to a process for the production of formyl cyclohexene derivatives which are suitable as odorants as such or as intermediates for the preparation of further odorants.
    Type: Application
    Filed: October 8, 2012
    Publication date: February 7, 2013
    Applicant: GIVAUDAN SA
    Inventor: Givaudan SA
  • Patent number: 8349822
    Abstract: This invention relates to compositions and methods utilizing a chemotherapeutic drug and 6-bromoindirubin3?-oxime (BIO) for the treatment of cancer, including glioblastoma multiforme. The present invention demonstrates that BIO works synergistically with chemotherapeutic drugs to increase the cytotoxic effects of these drugs in glioma cells.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: January 8, 2013
    Assignee: Cedars-Sinai Medical Center
    Inventor: John S. Yu
  • Patent number: 8334237
    Abstract: The present invention relates to oxime ether-, hydrazone- or azomethine-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the amidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Grant
    Filed: March 8, 2008
    Date of Patent: December 18, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Thomas Seitz, Klaus Kunz, Wahed Ahmed Moradi, Jörg Nico Greul, Darren James Mansfield, Urlich Heinemann, Amos Mattes, Oswald Ort, Jean-Pierre Vors, Peter Dahem, Ulrike Wachendorff-Neumann, Arnd Voerste
  • Publication number: 20120295886
    Abstract: The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): wherein R1, R2, and Y are as defined herein. Methods of preparing the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds in the treatment of viral infections such as influenza are also provided.
    Type: Application
    Filed: May 18, 2012
    Publication date: November 22, 2012
    Applicant: INFLUMEDIX, INC.
    Inventors: Jizhou Wang, Xiaodong Fan, Lidia Cristian
  • Patent number: 8278487
    Abstract: The present disclosure pertains to a process for preparing an oxime in which a carbonyl compound is reacted in the liquid phase with NH3 and H2O2 in the presence of a catalyst to form the corresponding oxime, wherein the catalyst comprises a catalytic component selected from the oxides of metals of group 5 and group 6. The use of a niobia catalyst is particularly preferred. The process according to the disclosure is suitable for the manufacture of numerous oximes, in particular cyclohexanone oxime.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: October 2, 2012
    Assignee: DSM IP Assets B.V.
    Inventor: Nirappurackal Raveendran Shiju
  • Patent number: 8258101
    Abstract: This invention relates to new peptide-based compounds and their use in therapeutically effective treatments as well as for diagnostic imaging techniques. More specifically the invention relates to the use of such peptide-based compounds used as targeting vectors that bind to receptors associated with angiogenesis, in particular the ?v?3 integrin receptor. Such contrast agents may thus be used for diagnosis of for example malignant diseases, heart diseases, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma. Moreover such compounds may also be used in therapeutic treatment of these diseases.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: September 4, 2012
    Assignee: GE Healthcare AS
    Inventor: Alan Cuthbertson
  • Patent number: 8084645
    Abstract: A compound of the present invention, or a pharmaceutically acceptable salt thereof is indicated by formula (1) below: wherein, R1, R2, R3, R4, R5, R6, Q, R8, and R9 have the same meanings as R1, R2, R3, R4, R5, R6, Q, R8, and R9 in the specification.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: December 27, 2011
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshiaki Isshiki, Yasunori Kohchi, Kazuo Hattori, Nobuo Shimma, Masanori Miwa, Naohito Inagaki, Hitoshi Iikura, Yasuaki Matsubara
  • Publication number: 20110293553
    Abstract: Compounds, compositions, kits, devices, and methods of attracting, detecting, eradicating, controlling, or killing an insect, such as a bed bug, by utilizing insect attractant, arresting, and/or aggregation compounds and compositions is provided. Insect attractant, arresting, and/or aggregation compounds identified from insect fecal extract by an analytical technique, such as gas chromatography, nuclear magnetic resonance (NMR), Carbon-13 NMR, mass spectroscopy, LC-MS, GC-MS, high performance liquid chromatography (HPLC), or combinations thereof are provided. A bed bug attractant, arresting, and/or aggregation compound identified from bed bug feces and exhibiting a Carbon-13 NMR peak at about ? 159.453 ppm is also provided.
    Type: Application
    Filed: May 28, 2010
    Publication date: December 1, 2011
    Inventors: Tai-Teh Wu, Kenneth Haynes, Joe Harold Hope, III
  • Patent number: 8021632
    Abstract: The invention relates to a plant for carrying out chemical reactions, having a reactor (1), the reaction space of which contains hydrogen peroxide (H2O2) and titanium silicalite (TS-1). The object of the invention is to improve such a plant such that continuous separation and recycling of the active catalyst to the reaction space is possible with a long filter service life. This is achieved in that the reaction space contains a solid silicon source, in that the plant comprises a water takeoff line (3) which is set up for drawing off water in addition to components which are dissolved and/or dispersed therein from the reaction space, in that the water takeoff line (3) leads to a filter (4) which separates off the components which are dissolved and/or dispersed in the water, and in that the plant has a return line (5) which is set up for recirculating to the reaction space components which are separated off by means of the filter (4).
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: September 20, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Goetz Baumgarten, Martin Roos, Stephan Schaeflein, Rolf Augenstein
  • Patent number: 7951607
    Abstract: The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (?) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: May 31, 2011
    Assignee: University of Wyoming
    Inventors: Robert C. Corcoran, Aaron D. Strickland
  • Patent number: 7884246
    Abstract: Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C1-C6 alkyl or halogen, and Alk is C1-C6 alkyl. The substituted anisidines of formula I have been found to be useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: February 8, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Fabrice Gallou, Heewon Lee, Chris Hugh Senanayake, Jinhua J. Song, Zhulin Tan, Jinghua Xu, Nathan K. Yee
  • Patent number: 7785549
    Abstract: A recycling system for hydroxylamine formation and oximation is proposed. The recycling system includes a hydroxylamine formation zone, an oximation zone, a purification zone, and an adjusting zone having a nitrate absorption tower. An inorganic process solution, used by the recycling system, partially enters the nitrate absorption tower supplementing nitrate, followed by mixing with the residual inorganic process solution, thereby reducing the loss rate of hydroxylamine in the inorganic process solution due to degradation. In addition, the organic impurities with high boiling point in the inorganic process solution can be effectively removed in the purification zone. As a result, the reduced activity or selectivity of the catalyst for hydroxylamine formation, caused by the toxic effects of these organic impurities on the catalyst, can be avoided, and hence, a high concentration of hydroxylamine can be obtained.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: August 31, 2010
    Assignee: China Petrochemical Development Corporation
    Inventors: Jih-Dar Hwang, Hsiu-Li Cheng, Shou-Li Luo
  • Publication number: 20100179317
    Abstract: A redox ammoximation process in which a ketone or aldehyde is reacted with ammonia and oxygen in the presence of a catalyst; wherein the catalyst is an aluminophosphate based redox catalyst having at least two different redox catalytic sites comprising different transition metal atoms.
    Type: Application
    Filed: July 2, 2008
    Publication date: July 15, 2010
    Applicant: University of Southampton
    Inventor: Robert RAJA
  • Patent number: 7745663
    Abstract: An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application].
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: June 29, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshiaki Isshiki, Yasunori Kohchi, Eisaku Mizuguchi, Hitoshi Iikura, Yasuaki Matsubara, Shinji Tsujii, Nobuo Shimma, Masanori Miwa, Satoshi Aida, Masami Kohchi, Takeshi Murata, Kosuke Aso
  • Patent number: 7696257
    Abstract: An oxime ester compound represented below is useful as a photopolymerization initiator. A photopolymerization initiator including this as an active constituent has high sensitivity and causes no concern about coloration or contamination. (X represents a halogen atom or alkyl group. R1, R2, and R3 each independently represent R, OR, COR, SR, CONRR?, or CN, wherein R and R? each represent an alkyl group, an aryl group, an aralkyl group, or a heterocyclic group; these groups may be substituted with (a) halogen atom(s) and/or (a) heterocyclic group(s); the alkylene moiety in the alkyl or aralkyl group may be interrupted by (an) unsaturated bond(s), (an) ether bond(s), (a) thioether bond(s), or (an) ester bond(s); and R and R? may form a ring. Y1 represents an oxygen, sulfur, or selenium atom; A represents a heterocyclic group; m represents an integer 0-4; p represents an integer 0-5; and q represents 0 or 1.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: April 13, 2010
    Assignee: Adeka Corporation
    Inventors: Mitsuo Akutsu, Daisuke Sawamoto, Yasunori Kozaki, Toshihiko Murai
  • Patent number: 7687220
    Abstract: The invention pertain to novel photoacid generator compounds of the formula I, II or III wherein R1 is for example C1-C18alkylsulfonyl or phenylsulfonyl, phenyl-C1-C3alkylsulfonyl, , naphthylsulfonyl, anthracylsulfonyl or phenanthrylsulfonyl, all optionally substituted, or R1 is a group X1, X2 and X3 independently of each other are O or S; R?1, is e.g. phenylenedisulfonyl, naphthylenedisulfonyl, diphenylenedisulfonyl, or oxydiphenylenedisulfonyl, all optionally substituted; R2 is halogen or C1-C10haloalkyl; X is halogen; Ar1 is for example biphenylyl or fluorenyl, or is substituted naphthyl; Ar?1 is heteroarylene, optionally substituted; R8, R9, R10 and R11 for example are C1-C6alkyl which is unsubstituted or substituted by halogen; or R8, R9 and R10 are phenyl which is unsubstituted or substituted by C1-C4alkyl or halogen; or R10 and R11 together are 1,2-phenylene or C2-C6alkylene which is unsubstituted or substituted by C1-C4alkyl or halogen.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: March 30, 2010
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hitoshi Yamato, Toshikage Asakura, Tobias Hintermann
  • Publication number: 20100069670
    Abstract: An oxidation catalyst for use in the oxidation of a substrate with a molecular oxygen, comprising at least one member selected from the group consisting of a specific hydrazyl radical (such as 2,2-diphenyl-1-picrylhydrazyl) and a specific hydrazine compound (such as 2,2-diphenyl-1-picrylhydrazine). A method for producing a chemical compound, comprising contacting a substrate with a molecular oxygen in the presence of the above-mentioned oxidation catalyst.
    Type: Application
    Filed: November 13, 2009
    Publication date: March 18, 2010
    Applicant: ASAHI KASEI CHEMICALS CORPORATION
    Inventor: Ken Suzuki
  • Publication number: 20100016637
    Abstract: The present invention provides a method for producing an oxime by carrying out an ammoximation reaction of a ketone with an organic peroxide and ammonia in a solvent in the presence of a titanosilicate, characterized in that the reaction is carried out by feeding the ketone and ammonia to a reactor in which the solvent, the titanosilicate and the organic peroxide are charged.
    Type: Application
    Filed: July 13, 2009
    Publication date: January 21, 2010
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Miyuki OIKAWA, Masaru KITAMURA
  • Patent number: 7642280
    Abstract: The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: January 5, 2010
    Assignees: The Regents of the University of California, National Institutes of Health
    Inventors: Robert C. Fahey, Gerald L. Newton, Carole A. Bewley, Gillian Nicholas
  • Publication number: 20090312434
    Abstract: The present invention relates to the use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug, with the exception of a neuroprotective drug, notably a cardioprotective or hepatoprotective drug.
    Type: Application
    Filed: February 23, 2007
    Publication date: December 17, 2009
    Applicant: TROPHOS
    Inventors: Rebecca Pruss, Bruno Buisson, Thierry Bordet
  • Patent number: 7608738
    Abstract: The present invention relates to a process for the coammoximation, that is to say for the simultaneous ammoximation, of ketones, in particular of cyclic ketones such as cyclododecanone and cyclohexanone. Ammoximation is taken to mean here the preparation of oximes from ketones or aldehydes together with hydrogen peroxide and ammonia and in the presence of a catalyst which essentially consists of silicon, titanium and oxygen, for example titanium silicalite.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: October 27, 2009
    Assignee: Degussa AG
    Inventors: Juergen Herwig, Martin Roos, Georg Oenbrink, Bernd Guenzel, Dirk Kuppert
  • Patent number: 7569727
    Abstract: Compounds of formula wherein A0, A1 and A2 are each independently of the others a bond or a C1-C6alkylene bridge; A3 is a C1-C6alkylene bridge which is unsubstituted or substituted by from one to six identical or different substituents selected from halogen and C3-C8cycloalkyl; Y is, for example, O, S, SO or SO2; M is O or NOR6, X1 and X2 are each independently of the other fluorine, chlorine or bromine; R1, R2 and R3 are, for example, H, halogen, OH, SH, CN, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylcarbonyl, C2-C6alkenyl, C2-C6haloalkenyl or C2-C6alkynyl; Q is, for example, O, S, SO or SO2; W is, for example, O, S, SO, SO2, —C(?O)—O— or —O—C(?O)—; T is, for example, a bond, O, S, SO, SO2, —C(?O)—O— or —O—C(?O)—; D is CH or N; R4 is, for example, H, halogen, OH, SH, CN, nitro, C1-C6alkyl or C1-C6haloalkyl; R5 is, for example, C1-C12alkyl, C3-C8cycloalkyl or —N(R7)2; R7 is H, C1-C6alkyl, C1-C3haloalkyl, C1-C6alkylcarbonyl, C1-C3haloalkylcarbonyl, C1-C6alkoxycarbonyl, C3-C8cycloalkyl, C3-C8 cycloalkyl
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: August 4, 2009
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Werner Zambach, Roger Graham Hall, Peter Renold, Stephan Trah
  • Publication number: 20090111965
    Abstract: The present application relates to semiconductor processing compositions comprising at least one compound containing at least one amidoxime functional group and to methods of using these compositions in semiconductor processing. The present application also describes the preparation of amidoximes for a semiconductor processing composition by (a) mixing a cyanoethylation catalyst, a nucleophile and an alpha-unsaturated nitrile to produce a cyanoethylation product; and (b) converting a cyano group in the cyanoethylation product into an amidoxime functional group.
    Type: Application
    Filed: October 29, 2008
    Publication date: April 30, 2009
    Inventor: Wai Mun Lee
  • Patent number: 7494760
    Abstract: A photoacid generator has formula (1) wherein R is H, F, Cl, nitro, alkyl or alkoxy, n is 0 or 1, m is 1 or 2, r is an integer of 0-4, and r? is an integer of 0-5. A chemically amplified resist composition comprising the photoacid generator has advantages including a high resolution, focus latitude, long-term PED dimensional stability, and a satisfactory pattern profile shape. When the photoacid generator is combined with a resin having acid labile groups other than those of the acetal type, resolution and top loss are improved. The composition is suited for deep UV lithography.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: February 24, 2009
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Youichi Ohsawa, Katsuya Takemura, Akihiro Seki
  • Patent number: 7473709
    Abstract: The present patent application relates to 11?-benzaldoxime derivatives of D-homooestra-4,9-dien-3-ones of formula I: wherein R1 is a hydrogen atom or a C1-C6-alkyl, C1-C6-acyl, C1-C4-alkoxycarbonyl, C1-C4-alkylthiocarbonyl, C1-C6-alkylaminocarbonyl or arylaminocarbonyl group; and R2 is a hydrogen atom or a C1-C6-alkyl or C1-C6-acyl group. Compounds of formula I bind more strongly to the glucocorticoid receptor than to the progesterone receptor and are effective antiglucocorticoids. According to the invention, they are suitable for the treatment and/or prevention of symptoms and/or diseases that are attributable to an androgen deficiency induced by glucocorticoids, especially cortisol.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: January 6, 2009
    Assignee: Bayer Schering Pharma AG
    Inventors: Sven Ring, Gerd Schubert, Lothar Sobek
  • Patent number: 7468458
    Abstract: Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: December 23, 2008
    Assignee: Amerx, Inc.
    Inventors: Feng Tian, Zhenwei Miao
  • Patent number: 7439396
    Abstract: Novel ligand compounds that activate RAR receptors have the following structural formula (I): and are suited for formulation into pharmaceutical compositions useful in human or veterinary medicine, or, alternatively, into cosmetic compositions.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: October 21, 2008
    Assignee: Galderma Research & Development
    Inventors: Thibaud Biadatti, Anne-Pascale Luzy
  • Publication number: 20080249300
    Abstract: The invention relates to a method for the coammoxidation, i.e. for the simultaneous ammoxidation of ketones, especially of cyclic ketones such as cyclododecanone and cyclohexanone. The ammoxidatian method of the invention relates to the production of oximes from ketones or aldehydes using hydrogen peroxide and amnmonia and further using a catalyst that substantially consists of silicon, titanium and oxygen, such as for example titanium silicalite.
    Type: Application
    Filed: August 2, 2004
    Publication date: October 9, 2008
    Applicant: Degussa AG
    Inventors: Juergen Herwig, Martin Roos, Georg Oenbrink, Bernd Guenzel, Dirk Kuppert
  • Patent number: 7423178
    Abstract: The invention relates to a process for treating an organic solution comprising cyclohexanone oxime, cyclohexanone and an organic solvent, said process comprising distilling the organic solution such as to obtain (i) a first product comprising organic solvent, (ii) a second product comprising cyclohexanone and (iii) a third product comprising cyclohexanone oxime; and feeding the second product to a cyclohexanone oxime synthesis zone in which hydroxylammonium is reacted with cyclohexanone to form cyclohexanone oxime.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: September 9, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Hendrik Oevering, Arno H Benneker, Johannes A L Brouwers
  • Patent number: 7408080
    Abstract: The present invention discloses a process for the ammoximation of carbonyl compounds, wherein a reaction in a liquid reaction system comprising a carbonyl compound, ammonia and hydrogen peroxide is carried out in the presence of a sillicon-containing catalyst, characterized in that a liquid silicon-containing assistant is added to the reaction system so that the silicon concentration in the system reaches a range of between 0.1 and 10000 ppm. In the process according to the present invention, the deactivation of catalyst due to dissolution of silicon in the catalyst can be reduced, thus lifetime of the catalyst extended and the stable operation time elongated.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: August 5, 2008
    Assignees: China Petroleum & Chemical Corporation, Research Institute of Petroleum Processing, Sinopec
    Inventors: Wei Wu, Bin Sun, Yongxiang Li, Shibiao Cheng, Enquan Wang, Shuzhong Zhang
  • Patent number: 7399577
    Abstract: Compounds of the formula (I) or (II) wherein R1 is C1-C10haloalkylsulfonyl, halobenzenesulfonyl, C2- C10haloalkanoyl, halobenzoyl; R2 is halogen or C1-C10 haloalkyl; Arl is phenyl, biphenylyl, fluorenyl, naphthyl, anthracyl, phenanthryl, or heteroaryl, all of which are optionally substituted; Ar?1 is for example phenylene, naphthylene, diphonylene, heteroarylene, oxydiphenylene, phenyleneD-D1-D-phenylene or —Ar?1-A1—Y1-A1—Ar?1—; wherein these radicals optionally are substituted; Ae?, is phenylene, naphthylene, anthracylene, phenanthrylene, or heteroarylene, all optionally substituted; A, is for example a direct bond, —0—, —S—, or —NR6—; Y, inter alia is C1-C18alkylene; X is halogen; D is for example —0—, —S— or —NR6—; D, inter alia is C1-C18alkylene; are particularly suitable as photolatent acids in ArF resist technology.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: July 15, 2008
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hitoshi Yamato, Toshikage Asakura, Akira Matsumoto, Peter Murer, Tobias Hintermann
  • Patent number: 7326511
    Abstract: Chemically amplified photoresist compositions comprising, (a) a compound which cures upon the action of an acid or a compound whose solubility is increased upon the action of an acid; and (b) a compound of the formula (Ia), (Ib), (IIa), (IIb), (IIIa), (IIIb), (Iva), (Ivb), (Va), (Vb) or (VIa), wherein n is 1 or 2; m is 0 or 1; X0 is —[CH2]h—X or —CH?CH2; h is 2, 3, 4, 5 or 6; R1 when n is 1, is for example optionally substituted phenyl, naphthyl, anthracyl, phenanthryl, or heteroaryl; R1, when n is 2, is for example optionally substituted phenylene or naphthylene; R2 for example has one of the meanings of R1; X is for example —OR20, —NR21R22, —SR23; X? is -X1-A3-X2-; X1 and X2 are for example —O—, —S— or a direct bond; A3 is e.g. phenylene; R3 has for example one of the meanings given for R1; R4 has for example one of the meaning given for R2; R5 and R6 e.g. are hydrogen; G i.a. is —S— or —O—; R7 when n is 1, e.g. is phenyl, optionally substituted, when n is 2, is for example phenylene; R8 and R9 e.g.
    Type: Grant
    Filed: January 28, 2003
    Date of Patent: February 5, 2008
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Akira Matsumoto, Hitoshi Yamato, Toshikage Asakura, Peter Murer
  • Patent number: 7279600
    Abstract: This invention provides estrogen receptor modulators having the structure: wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: October 9, 2007
    Assignee: Wyeth
    Inventors: Richard Eric Mewshaw, Cuijian Yang
  • Patent number: 7253319
    Abstract: Compounds of the formula where the variables have the values described in the specification are antagonists of RAR? retinoid receptors.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: August 7, 2007
    Assignee: Allergan, Inc.
    Inventors: Kwok Yin Tsang, Santosh Sinha, Xiaoxia Liu, Smita Bhat, Roshantha A. Chandraratna
  • Patent number: 7244544
    Abstract: New oxime sulfonate compounds of the formula I, II, III, IV, V, VI and VII R1 is for example C1–C18alkylsulfonyl, R2 is halogen or C1–C10haloalkyl; R3 is for example unsubstitude or substituted phenylenedisulfonyl, diphenylenedisulfonyl, or oxydiphenylenedisulfonyl; Ar1 is for example a direct bond, C1–C12alkylene; —O—C-bond or a —O—Si-bond which cleaves upon the action of an acid; A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, A11 and A12 are for example a direct bond, —O—, or —S—, or are C1–C12alkylene or phenylene unsubstituted or substituted; Y1 is C1–C12alkylene which is for example substituted by OR4, or SR7; Y2 is e.g. a trivalent radical of C1–C12alkylene; Y3 is e.g. a tetravalent radical of C1–C12alkylene; X is halogen; Ar?1 is for example C1–C12alkyl which is unsubstituted or substituted; Ar?1 is for example phenylene; provided that at least one of the radicals Ar?1, Ar?1, is substituted by 1 to 3 groups of example halogen; R15, R16, R17 and R18 e.g.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: July 17, 2007
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hitoshi Yamato, Toshikage Asakura, Akira Matsumoto, Masaki Ohwa
  • Patent number: 7232928
    Abstract: Cycloalkanone oxime is stabilized by a method comprising bringing the cycloalkanone oxime into contact with at least one compound selected from the group consisting of oxoacids, oxoacid salts, oxoacid esters, oxoacid amides and oxides of boron or phosphorus. In accordance with the invention, the thermal stability of cycloalkanone oxime can be improved.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: June 19, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masami Fukao, Noriaki Tanaka
  • Patent number: 7164047
    Abstract: A process for preparation of cyclopropylethanol, which comprises subjecting a 3-cyclopropyl-2,3-epoxypropionic acid ester to solvolysis, treating the product of the solvolysis with an acid to obtain cyclopropylacetaldehyde, and reducing the obtained cyclopropylacetaldehyde; and a process for preparation of cyclopropylacetonitrile, which comprises subjecting a 3-cyclopropyl-2,3-epoxypropionic acid ester to solvolysis in the presence of a base, treating the product of the solvolysis with an acid to obtain cyclopropylacetaldehyde, reacting the obtained cyclopropylacetaldehyde with hydroxylamine or salts thereof to obtain cyclopropaneacetaldehyde oxime, and reacting the obtained cyclopropaneacetaldehyde oxime with acetic anhydride. According to the present invention, cyclopropylethanol and cyclopropylacetonitrile can be prepared at low costs and industrially advantageously.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: January 16, 2007
    Assignee: Kuraray Co., Ltd.
    Inventor: Katsuji Ujita
  • Patent number: 7161036
    Abstract: A process for producing an oxime is provided, wherein the process comprises the step of reacting a ketone, hydrogen peroxide and ammonia in the presence of a crystalline titanosilicate having MWW structure under the condition that the ammonia concentration in the liquid portion of the reaction mixture is about 1% by weight or more. By the process, an ammoximation reaction of the ketone can be carried out with a high conversion of the ketone and a high selectivity to the oxime corresponding to the ketone, thereby producing the oxime with a high yield.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 9, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Miyuki Oikawa, Masami Fukao
  • Patent number: 7148381
    Abstract: A process is described for the activation of zeolitic catalysts containing titanium having the formula: xTiO2(1-x)SiO2 wherein x ranges from 0.0001 to 0.4, which consists in treating said materials with a solution of an ammonium salt of a carboxylic acid and subsequently subjecting them to calcination. The catalysts thus treated have higher catalytic performances with respect to those not treated, in oxidation processes of organic substrates.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: December 12, 2006
    Assignee: Polimeri Europa S.p.A.
    Inventors: Vittorio Arca, Angelo Boscolo Boscoletto, Nicola Fracasso, Piero Furlan, Laura Meda
  • Patent number: 7098357
    Abstract: The present invention relates to a process for the dehydration of organic compounds to give unsaturated compounds.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: August 29, 2006
    Assignee: Merck Patent GmbH
    Inventors: Hanns Wurziger, Guido Pieper, Norbert Schwesinger
  • Patent number: 7034184
    Abstract: A process comprising allowing a peroxide compound represented by following Formula (2): wherein Ra, Rb, Rc and Rd are the same or different and are each a hydrogen atom or a hydrocarbon group, and wherein Ra and Rb, Rc and Rd may be combined to form a ring together with the adjacent carbon atom, respectively, to react with ammonia and water to yield an azine compound represented by following Formula (3): wherein Ra, Rb, Rc and Rd have the same meanings as defined above, or oxime compounds represented by following Formulae (4a) and/or (4b): wherein Ra, Rb, Rc and Rd have the same meanings as defined above, in the presence of a nitrogen-containing cyclic compound constitutively having a skeleton represented by following Formula (A) in its ring: wherein X is one of an oxygen atom and an —OR group, and wherein R is one of a hydrogen atom and a hydroxyl-protecting group.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: April 25, 2006
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Yasutaka Ishii, Tatsuya Nakano
  • Patent number: 7026094
    Abstract: New oxime sulfonate compounds of the formula (I) and (II), wherein R1 is C1-C12alkyl, C1C4haloalkyl, hydrogon, OR9, NR10R11, SR12 or is phenyl which is unsubstituted or substituted by OH, C1-C18alkyl, halogen and/or C1-C12alkoxy; R2, R3, R4 and R5 are for example hydrogen or C1-C12alkyl; R6 is for example is C1-C18alkylsulfonyl, phenyl-C1-C3alkylsulfonyl or phenylsulfonyl; R?6 is for example phenylenedisulfonyl or diphenylenedisulfonyl; R7, R8 and R9 for example are hydrogen or C1-C6alkyl; R10 and R11, are for example hydrogen or C1-C18alkyl; R12 is for example hydrogen, phenyl or C1-C18alkyl; A is S, O, NR13, or a group of formula A1, A2 or A3, R21 and R22 independently of one other have one of the meanings given for R7; R23, R24, R25 and R26 independently of one another are for example hydrogen, C1-C4alkyl, halogen or phenyl; Z is CR22 or N; and Z1 is CR22 or N; and Z1 is CR22 or N; and Z1 is CH2, S, O or NR13 are particularly suitable as photo-latent acids in resist applications.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: April 11, 2006
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Akira Matsumoto, Hitoshi Yamato, Toshikage Asakura, Masaki Ohwa, Peter Murer
  • Patent number: 6958405
    Abstract: Catalysts useful for oxidation reactions are disclosed. The catalysts comprise a polymer-encapsulated titanium zeolite. The catalysts are easy to prepare and use, they are easy to recover and reuse, and they provide good conversions in a variety of important oxidation processes. The invention includes a process which comprises oxidizing an organic compound in the presence of hydrogen peroxide and a polymer-encapsulated titanium zeolite. In one example, the organic compound is propylene and the reaction product is propylene oxide.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: October 25, 2005
    Assignee: ARCO Chemical Technology, L.P.
    Inventors: Bi Le-Khac, Roger A. Grey