Additional Carbonyl Bonded Directly To Urea Nitrogen Patents (Class 564/44)
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Patent number: 8980970Abstract: The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups) and 3) optionally NCO-reactive groups, by reacting at temperatures ?130° C. A) one or more NCO-functional compounds containing uretdione groups with B) one or more compounds that contain isocyanate-reactive groups and groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and then C) with one or more saturated, hydroxyl-containing compounds other than B), at least one of these compounds having an OH functionality of ?2, in the presence of D) a catalyst containing one or more zinc compounds, the reaction with compounds C) taking place at least proportionally with the formation of allophanate groups. The present invention also relates to the binders obtained by the process of the invention.Type: GrantFiled: September 1, 2005Date of Patent: March 17, 2015Assignee: ALLNEX IP S.a.r.L.Inventors: Jan Weikard, Dorota Greszta-Franz, Wolfgang Fischer, Jörg Schmitz, Holger Mundstock, Christophe Detrembleur
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Patent number: 8957176Abstract: The invention provides innovative blocked polyisocyanates whose crosslinking is initiated thermally and photochemically. The polyisocyanates comprise at least one thermally reversibly blocked NCO group whose blocking agent contains at least one group which on exposure to actinic radiation reacts, with polymerization, with ethylenically unsaturated compounds. A process for preparing the polyisocyanates, and their use in binders, is also provided.Type: GrantFiled: September 2, 2005Date of Patent: February 17, 2015Assignee: ALLNEX IP S.à.r.L.Inventors: Thomas Fäcke, Jan Weikard, Wolfgang Fischer
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Patent number: 8952120Abstract: An isocyanurate type polyisocyanate composition which is derived from an aliphatic diisocyanate monomer and an alcohol and satisfies all of the following requirements when it contains substantially no aliphatic diisocyanate monomer and substantially no solvent: 1) the viscosity at 25° C. is 500-1,500 mPa·s; 2) the isocyanurate trimer concentration is 60-95 mass %; 3) when the number of allophanate bonds is expressed as A and the number of isocyanurate bonds is expressed as B, the proportion of the allophanate bonds, a=(A/(A+B))×100, is 1-30%; and 4) when the number of urethodione bonds is expressed as D, the proportion of the urethodione bonds, d=(D/(B+D))×100, is less than 2%.Type: GrantFiled: September 21, 2006Date of Patent: February 10, 2015Assignee: Asahi Kasei Chemicals CorporationInventors: Yoshiyuki Asahina, Masakazu Yamauchi
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Patent number: 8853295Abstract: The present invention relates to a process for the preparation of particularly reactive and low-viscosity reaction products of polyisocyanates which contain activated ethylenically unsaturated groups which react by polymerization under the action of actinic radiation, and the use of these reaction products in coating compositions, and particularly scratch-resistant coatings obtainable therefrom.Type: GrantFiled: February 12, 2010Date of Patent: October 7, 2014Assignee: ALLNEX IP S.a.r.L.Inventors: Michael Ludewig, Wolfgang Fischer, Helmut Kuczewski
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Patent number: 8729210Abstract: Prepolymers, which are accessible from formamides of low molecular weight di- or triamines (formamide-terminated low molecular weight compounds) and di- or polyisocyanates, of the general formula (II): X—[—N(CHO)—CO—NH—R1—NCO]n??(II) wherein X represents a linear or branched aliphatic, cycloaliphatic, heterocyclic and/or aromatic structural unit having 2 to 40 carbon atoms, and which is optionally further substituted and/or optionally comprises one or more heteroatoms, wherein R1 represents an organic radical which may optionally contain one or more heteroatoms and which may further contain one or more additional free isocyanate groups and/or one or more urethane, biuret, carbodiimide, isocyanurate, allophanate, iminooxadiazinedione and/or uretdione structural units, and wherein n?2; processes for making the same; compositions containing the same; and uses thereof.Type: GrantFiled: July 16, 2010Date of Patent: May 20, 2014Assignee: Bayer MaterialScience AGInventors: Harald Blum, Evelyn Peiffer, Marc Leimenstoll
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Patent number: 8716426Abstract: A process for the preparation of an allophanate of one or more identical or different isocyanates, compositions obtained by the process, and uses of the compositions are disclosed. The process comprises reacting an isocyanate with at least one monoalcohol comprising an ether or polyether functional group in the presence of a bismuth-comprising catalyst and a metal compound as co-catalyst.Type: GrantFiled: December 8, 2009Date of Patent: May 6, 2014Assignee: Perstorp FranceInventors: Jean-Marie Bernard, Johannès Schwarz, Philippe Olier
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Patent number: 8604097Abstract: The present invention relates to a process for preparing radiation-curing binders containing allophanate groups by reacting, at temperatures of ?130° C., A) one or more compounds containing uretdione groups with B) one or more OH-functional compounds which contain groups which react, with polymerization, with ethylenically unsaturated compounds on exposure to actinic radiation (radiation-curing groups), C) optionally NCO-reactive compounds other than B), in the presence of D) a catalyst containing at least one zinc compound, to form allophanate groups by opening the uretdione ring. The present invention also relates to the binders obtained by the process of the invention and to coating compositions containing these binders.Type: GrantFiled: January 27, 2011Date of Patent: December 10, 2013Assignee: Bayer MaterialScience AGInventors: Jan Weikard, Christophe Detrembleur, Dorota Greszta-Franz, Frank Richter, Wolfgang Fischer, Jörg Schmitz, Holger Mundstock
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Patent number: 8445622Abstract: The present invention relates to a process for preparing polyisocyanates by oligomerization of isocyanates.Type: GrantFiled: November 30, 2007Date of Patent: May 21, 2013Assignee: BASF SEInventors: Horst Binder, Hubert Graf
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Patent number: 8378139Abstract: A process for oligomerizing isocyanates includes a step of continuous conversion of an isocyanate monomer into polyisocyanate containing carbamate and/or allophanate groups, in the presence of a catalyst, wherein the conversion step is carried out in a reactor having a specific heat exchange coefficient of greater than or equal to approximately 200 kW/m3/° C.Type: GrantFiled: April 2, 2009Date of Patent: February 19, 2013Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Institut National Polytechnique de Toulouse, Perstorp FranceInventors: Hocine Kabir, Johannes Schwarz, Christophe Gourdon, Sébastien Elgue
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Patent number: 8367794Abstract: The invention relates to liquid polyisocyanate mixtures, to a process for their preparation and to their use in single- and two-component polyurethane coating compositions.Type: GrantFiled: September 12, 2008Date of Patent: February 5, 2013Assignee: Bayer MaterialScience AGInventor: Christian Wamprecht
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Patent number: 8334357Abstract: Disclosed is a thickener based on an aqueous preparation of a nonionic, water-dispersible or water-soluble polyurethane, obtained by reacting: (a) hydrophilic polyols containing at least two OH groups and at least two functional groups selected from ether and ester, of molecular weight at least 300; (b) hydrophobic compounds containing at least one zerewitinoff-active hydrogen atom, of molecular weight about 100 to about 500, with at least one linear or branched, saturated or unsaturated alkyl chain having at least five consecutive carbon atoms not linked to a hetero atom; and (c) at least difunctional isocyanates, where the components are reacted in equivalent ratios OHa):ZHb):NCOc) of 1:(1+x):2(1+y), with the provisos that x is 0.05-1.2, y is (0.2-1.05)x, and more than one equivalent of NCOc) is present versus the sum of OHa) and ZHb).Type: GrantFiled: June 22, 2005Date of Patent: December 18, 2012Assignee: Cognis IP Management GmbHInventors: Ludwig Schieferstein, Oliver Pietsch
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Patent number: 8158817Abstract: The invention relates to a process for the synthesis of a polyisocyanate composition comprising acylureas. According to the invention, a starting composition comprising a compound having at least two isocyanate functional groups is subjected to a reaction with at least two acid functional groups, with at least one of the acid functional groups having a pKa value of less than or equal to 3, and at least one of the acid functional groups having a pKa value of more than 3 and less than or equal to 6, at a temperature at least equal to 50 ° C., wherein the acid functional group having a pKa value of less than or equal to 3 and the acid functional group having a pKa value of more than 3 and less than or equal to 6 are present on two different acids or on the same acid.Type: GrantFiled: March 1, 2010Date of Patent: April 17, 2012Assignee: Perstorp FranceInventors: Jean-Marie Bernard, Denis Revelant, Cédric Amouyal
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Patent number: 8148488Abstract: Disclosed is a polyisocyanate composition which is excellent in both curability and drying characteristic. The polyisocyanate composition contains at least one compound selected from aliphatic diisocyanates, at least one compound selected from alicyclic diisocyanates and at least one compound selected from polyols, while satisfying all of the following conditions; i) the diisocyanate monomer concentration is not more than 3 mass %, ii) the polyol component concentration is 1-50 mass %; and iii) the glass transition temperature is from ?50° C. to 0° C.Type: GrantFiled: March 1, 2005Date of Patent: April 3, 2012Assignee: Asahi Kasei Chemicals CorporationInventors: Yoshiyuki Asahina, Masakazu Yamauchi, Hironori Katagawa
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Patent number: 8106141Abstract: Reaction products prepared from reactants including: (a) at least one compound of structural Formula (I): wherein R1 is selected from aryl and heteroaryl; X is selected from a direct bond, —O—, —S—, —NH—, alkylene, cycloalkylene, heterocyclylene, arylene, alkarylene, and heteroarylene; Y is a substituted alkylene group having at least two contiguous carbon atoms and which can be interrupted by one or more —O—, —S—, or —NH— moieties as defined herein, wherein the alkylene group of Y has substituents independently selected from —OH, —NH2, —SH, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or two hydrogen atoms on the same carbon atom of Y are replaced by carbonyl, and wherein at least two substituents of Y are each independently selected from —OH, —NH2, and —SH, as defined herein; and (b) at least one isocyanate functional material.Type: GrantFiled: May 7, 2008Date of Patent: January 31, 2012Assignee: Henkel CorporationInventors: Anthony F. Jacobine, Andrew Messana, David M. Glaser, Steven Thomas Nakos
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Publication number: 20110275663Abstract: The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.Type: ApplicationFiled: April 16, 2009Publication date: November 10, 2011Inventors: Martial Ruat, Hélène Faure, Elisabeth Traiffort, Angèle Schoenfelder, André Mann, Maurizio Taddei, Antonio Solinas, Fabrizio Manetti
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Patent number: 7923574Abstract: The invention relates to novel prepolymers which are accessible from the formamides of oligomeric di- or polyamines (formamide-terminated oligomers) and di- or polyisocyanates.Type: GrantFiled: February 23, 2009Date of Patent: April 12, 2011Assignee: Bayer MaterialScience AGInventors: Marc Leimenstoll, Burkhard Köhler, Christos Karafilidis, Matthias Wintermantel
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Publication number: 20110071142Abstract: The present invention relates to methods of identifying small molecule candidate agents capable of modulating transcription factor function such that the function/expression of a target transcription factor and/or proteins downstream of this target protein comprises the screening of small molecule libraries using in silico high throughput docking for candidate small molecules/agents that are selectively identified for their ability to target and disrupt the transcription factor-DNA interface through unique transcription factor and/or DNA descriptors that are defined within a pharmacophore, and then testing/evaluating the candidate agents identified above through one or more in vitro assays for their ability to modulate transcription factor function including expression of this target protein and/or proteins that are downstream of the target transcription factor. The present invention also relates to various compounds described herein (e.g.Type: ApplicationFiled: March 19, 2010Publication date: March 24, 2011Applicant: BETH ISRAEL DEACONESS MEDICAL CENTERInventors: Peter Oettgen, Alan C. Rigby, Towia Libermann
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Patent number: 7902315Abstract: The present invention relates to a process for preparing radiation-curing binders containing allophanate groups by reacting at temperatures of ?130° C. A) one or more compounds containing uretdione groups with B) one or more OH-functional compounds which contain groups which react, with polymerization, with ethylenically unsaturated compounds on exposure to actinic radiation (radiation-curing groups), C) optionally NCO-reactive compounds other than B), in the presence of D) a catalyst containing at least one zinc compound, to form allophanate groups by opening the uretdione ring.Type: GrantFiled: September 1, 2005Date of Patent: March 8, 2011Assignee: Bayer MaterialScience AGInventors: Jan Weikard, Christophe Detrembleur, Dorota Greszta-Franz, Frank Richter, Wolfgang Fischer, Jörg Schmitz, Holger Mundstock
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Publication number: 20100280124Abstract: Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders.Type: ApplicationFiled: June 25, 2008Publication date: November 4, 2010Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Meir Bialer, Boris Yagen, Jakob Avi Shimshoni
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Patent number: 7786326Abstract: The present invention relates to a polyacylurethane having the following general formula (I) and a process for the preparation of such polyacylurethane. Preferred embodiments of the polyacylurethanes according to the invention have elastomeric properties. The polyacylurethanes can suitable be used in biodegradable, biocompatible and/or biomedical devices.Type: GrantFiled: July 21, 2005Date of Patent: August 31, 2010Assignee: Stichting Voor de Technische WetenschappenInventors: Ralf Guillaume Jean Catharina Heijkants, Arend Jan Schouten, Leendert Willem Schwab, Frans Vincent Roukes, Albert Johan Pennings
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Patent number: 7700662Abstract: The present invention relates to a process for preparing low-viscosity, allophanate-containing and NCO-free polyurethane prepolymers curable by actinic radiation, and to the products obtainable by this process. The prepolymers have residual monomer contents of less than 0.5% by weight and an NCO content of less than 1% by weight, and are prepared by a process in which A) diisocyanates, B) hydroxy-functional compounds containing groups which react with ethylenically unsaturated compounds on exposure to actinic radiation, and C) polyester, polyether or polycarbonate polyols having a functionality of at least 1.Type: GrantFiled: March 30, 2007Date of Patent: April 20, 2010Assignee: Bayer MaterialScience AGInventors: Michael Ludewig, Jan Weikard, Nicolas Stoeckel, Wolfgang Fischer
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Patent number: 7645798Abstract: N-(2-hydroxyalkanoyl)-N,N?-dialkylureas of general formula (1) are described A-X-(A)m??(1) where A: m=0 or m=1; when m=0, X=R??, where R?? is an aliphatic, cycloaliphatic, arylaliphatic radical, C1-C18; when m=1, X=—(CH2)n—, where n is an integer from 1 and 20, preferably from 2 to 6; R is chosen among H, and alkyl radicals C1-C8, possibly substituted with halogen atoms; R? is an aliphatic, cycloaliphatic, arylaliphatic radical, C1-C18; R? is chosen among H, aliphatic, cycloaliphatic, arylaliphatic radical, C1-C18. The preparation of said compounds is described, as well as the preparation of corresponding polymers.Type: GrantFiled: November 19, 2007Date of Patent: January 12, 2010Assignee: CHORISIS S.r.l.Inventors: Guido Galliani, Marco Orlandi, Bruno Rindone, Alberto Terraneo
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Publication number: 20090176786Abstract: The present invention relates to a benzoylurea compound represented by formula (I): wherein, X and Y represent a fluorine atom or a chlorine atom, R1 represents a lower alkyl group or the like, R2 represents a lower alkyl group, R3 represents a halogen atom or the like, R4 represents an alkylthio group optionally substituted with one or more of halogen atoms, or a salt thereof, and use thereof for controlling pests and the like.Type: ApplicationFiled: October 16, 2006Publication date: July 9, 2009Inventors: Masato Konobe, Shigeyuki Itoh, Norihisa Sakamoto, Araki Tomohiro, Yoshitomo Tohyama
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Patent number: 7553963Abstract: This invention relates to storage-stable, liquid, partially trimerized and allophanized polyisocyanates having an NCO group content of 15 to 41% by weight, and comprising 5 to 85% by weight of toluene diisocyanate, 5 to 85% by weight of a polyisocyanate of the diphenyl-methane series and an organic compound or mixture thereof. The present invention also relates to a process for the preparation of the storage-stable, liquid, partially trimerized and allophanized polyisocyanates; to storage-stable, liquid urethane prepolymers of these partially trimerized and allophanized polyisocyanates; and to a process for the production of these storage-stable, liquid, urethane prepolymers.Type: GrantFiled: October 29, 2003Date of Patent: June 30, 2009Assignee: Bayer MaterialScience LLCInventors: William E. Slack, Hersel T. Kemp, II
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Publication number: 20080153802Abstract: Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.Type: ApplicationFiled: December 21, 2006Publication date: June 26, 2008Applicant: THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCHInventors: Guillaume Laurent Lessene, Jonathan Baell
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Patent number: 7323532Abstract: The present invention concerns a process for producing low-viscosity polyisocyanates or secondary products thereof, which carry activated, radiation-curable double bonds and can optionally also cure thermally, and low-viscosity polyisocyanate mixtures or secondary products thereof and their use in coating compounds.Type: GrantFiled: September 29, 2003Date of Patent: January 29, 2008Assignee: Bayer MaterialScience AGInventors: Thomas Fäcke, Jan Weikard, Wolfgang Fischer
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Patent number: 7323496Abstract: Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.Type: GrantFiled: May 7, 2003Date of Patent: January 29, 2008Assignee: Theracos, Inc.Inventors: Partha Neogi, Debedranath Dey, Joseph Fuller, Liang Chen, Ta-Kai Li
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Patent number: 7288213Abstract: A method is described for preparing a tricondensate polyfunctional isocyanate composition, preferably having at least an isocyanurate and/or biuret group, which includes adding to a tricondensate polyfunctional isocyanate, or a mixture of different tricondensate polyfunctional isocyantes, obtained by (cyclo)condensation, in particular (cyclo)trimerization of one or several identical or different isocyanate monomers and optionally of another monomer, an allophanate of one or several identical or different isocyanates, or a mixture of different allophanates. The isocyanates or isocyanate monomer mixtures used for preparing the polyfunctional isocyanate(s) may be identical to or different from the isocyanate(s) or isocyanate mixture used for preparing the allophanate(s).Type: GrantFiled: April 21, 1999Date of Patent: October 30, 2007Assignee: Rhodia ChimieInventors: Eugénie Charriere, Jean-Marie Bernard, Denis Revelant
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Patent number: 7268202Abstract: A polyisocyanate composition comprising an allophanate group, which is obtained from an aliphatic diisocyanate(s), wherein in a state substantially free of a solvent and the aliphatic diisocyanate(s), (i) the content of components having a molecular weight of 700 or less is 20-60 weight %, (ii) the ratio of weight average molecular weight to number average molecular weight is 1.20-5.00, (iii) the ratio of viscosity (unit: mPa·s) of the polyisocyanate composition at 25° C. to the number average number of functional groups of isocyanate groups is represented by the following expression: viscosity(mPa·s)/number average number of functional groups?240.Type: GrantFiled: September 17, 2002Date of Patent: September 11, 2007Assignee: Asahi Kasei Chemicals CorporationInventors: Shinichiro Watanabe, Kunio Naoi
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Patent number: 7232929Abstract: The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain.Type: GrantFiled: February 15, 2004Date of Patent: June 19, 2007Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Meir Bialer, Boris Yagen, Eyal Sobol, Dan Kaufmann
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Patent number: 7179941Abstract: The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.Type: GrantFiled: January 23, 2004Date of Patent: February 20, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: Elisabeth Defossa, Dieter Kadereit, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Karl Schoenafinger, Alfons Enhsen
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Patent number: 7038003Abstract: A process for preparing polyisocyanate prepolymers containing allophanate structural units that includes reacting a) one or more polyisocyanates with b) one or more polyetherpolyols containing less than or equal to 0.02 milliequivalent of unsaturated end groups per gram of polyol and having a polydispersity of from 1.0 to 1.5 and/or an OH functionality of greater than or equal to 1.9 ?to provide an NCO-functional polyurethane prepolymer containing urethane groups that are partly or fully allophanatized by further reaction with c) polyisocyanates, which may be different from those from a), and d) catalysts and optionally adding e) acidic additives before, during and/or after the allophanatization. The polyisocyanate prepolymers can be used to produce coatings, adhesive bonds and/or seals. The coatings include one or more of the polyisocyanate prepolymers, and at least one diol or polyol and/or at least one linear and/or cyclic, aliphatic, araliphatic and/or aromatic diamine or polyamine.Type: GrantFiled: March 23, 2005Date of Patent: May 2, 2006Assignee: Bayer MaterialScience AGInventors: Michael Mager, Joachim Simon, Malte Homann
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Patent number: 7033522Abstract: A blocked polyisocyanate adduct including 5 to 95% by weight of at least one isocyanate component having at least one NCO group, the isocyanate component selected from the group consisting of aliphatic, cycloaliphatic and aromatic isocyanates, wherein the isocyanate has an average molecular weight of up to 1000 g/mol and an average NCO functionality of 2–4; 5 to 70% by weight of at least one hydrophilicizing component containing at least one group which is reactive toward the at least one NCO group; at least one blocking agent for blocking from 95 to 100% of the NCO groups which do not react with the hydrophilicizing component; and up to 15% by weight of at least one neutralizing agent.Type: GrantFiled: September 27, 2001Date of Patent: April 25, 2006Assignee: Degussa AGInventors: Klaus-Peter Jonderko, Klaus Janischewski, Lutz Mindach
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Patent number: 6887399Abstract: The present invention relates to a new high functionality MDI. In particular, this invention relates to polymeric allophanates based on diphenylmethane diisocyanate having an NCO group content of 12 to 30%, prepolymers thereof, and processes for the production of these compositions. The prepolymers are stable liquids having NCO group contents of about 10 to about 28%.Type: GrantFiled: September 9, 2002Date of Patent: May 3, 2005Assignee: Bayer MaterialScience LLPInventors: William E. Slack, Hersel T. Kemp, II, William E. Miller
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Patent number: 6888028Abstract: Using at least one compound selected from the group consisting of a zirconyl compound and a zirconium alcoholate as an allophanation catalyst, an allophanate group-containing polyisocyanate composition is produced from a starting material of at least one isocyanate compound selected from the group consisting of an aliphatic diisocyanate, an alicyclic diisocyanate and an isocyanate pre-polymer obtained therefrom, and another starting material of a hydroxyl group-containing compound.Type: GrantFiled: October 16, 2001Date of Patent: May 3, 2005Assignee: Asahi Kasei Kabushiki KaishaInventors: Shinichiro Watanabe, Kunio Naoi
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Patent number: 6812250Abstract: The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.Type: GrantFiled: May 24, 2002Date of Patent: November 2, 2004Assignee: Aventis Pharma Deutschland GmbHInventors: Elisabeth Defossa, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Erich von Roedern, Stefan Peukert, Alfons Enhsen, Armin Bauer, Bernd Neises, Karl Ulrich Wendt
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Publication number: 20040152743Abstract: The invention relates to heterocyclically substituted benzoylureas and also to their physiologically tolerated salts and physiologically functional derivatives.Type: ApplicationFiled: July 11, 2003Publication date: August 5, 2004Applicant: Aventis Pharma Deutschland GmbHInventors: Karl Schoenafinger, Elisabeth Defossa, Dieter Kadereit, Erich Von Roedern, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt
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Publication number: 20040097593Abstract: Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.Type: ApplicationFiled: May 7, 2003Publication date: May 20, 2004Inventors: Partha Neogi, Debedranath Dey, Joseph C. Fuller, Liang Chen, Ta-Kai Li
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Patent number: 6734321Abstract: The invention relates to novel composite materials comprising (a) an inorganic or organic bulk material having covalently bound to its surface initiator moieties for radical polymerization; and (b) a hydrophilic surface coating obtainable by applying one or more different ethylenically unsaturated hydrophilic macromonomers of formula (1) as outlined in the claims to the bulk material surface provided with the initiator radicals and polymerizing said macromonomers. The composite materials of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.Type: GrantFiled: June 20, 2002Date of Patent: May 11, 2004Assignee: Novartis AGInventors: Peter Chabrecek, Jens Höpken, Dieter Lohmann
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Publication number: 20040087659Abstract: The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives.Type: ApplicationFiled: July 11, 2003Publication date: May 6, 2004Inventors: Elisabeth Defossa, Dieter Kadereit, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Karl Schoenafinger
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Patent number: 6710085Abstract: The present invention is directed to new compositions of matter comprising the reaction products of a carboxylic acid and a urea having the formula: where R1, R2, R3 and R4 are the same or different and are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl, allyl, vinyl and alkoxyl groups having from 1-6 carbon atoms, substituted and unsubstituted phenyl groups and the halides. Preferably, the reaction product of the present invention is N,N′-diformylurea or N,N′-diacetylurea. These reaction products, e.g., diformylurea, have been found to produce significantly improved growth in a variety of agricultural products when applied to the seed, to the surrounding soil or to the foliage of the emerging plant. Because of the similarity in the carbon, nitrogen, oxygen structure of these reaction products with many biological compounds, it is believed that the reaction products of the present invention may find use in a variety of biological applications.Type: GrantFiled: July 29, 2002Date of Patent: March 23, 2004Assignee: Stoller Enterprises, Inc.Inventor: Frank William Dean
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Publication number: 20030176497Abstract: The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives.Type: ApplicationFiled: May 24, 2002Publication date: September 18, 2003Inventors: Elisabeth Defossa, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Erich von Roedern, Stefan Peukert, Alfons Enhsen, Armin Bauer, Bernd Neises, Karl Ulrich Wendt
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Patent number: 6506778Abstract: The invention is directed to acylphenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and a process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.Type: GrantFiled: June 8, 2001Date of Patent: January 14, 2003Assignee: Aventis Pharma Deutschland GmbHInventors: Elisabeth Defossa, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Heinz Baringhaus
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Publication number: 20020151586Abstract: The invention is directed to acylphenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives.Type: ApplicationFiled: June 8, 2001Publication date: October 17, 2002Inventors: Elisabeth Defossa, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Heinz Baringhaus
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Patent number: 6448440Abstract: The present invention is directed to new compositions of matter comprising the reaction products of a carboxylic acid and a urea having the formula where R1, R2, R3 and R4 are the same or different and are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl, allyl, vinyl and alkoxyl groups having from 1-6 carbon atoms, substituted and unsubstituted phenyl groups and the halides. Preferably, the reaction product of the present invention is N,N′-diformylurea or N,N′-diacetylurea. These reaction products, e.g., diformylurea, have been found to produce significantly improved growth in a variety of agricultural products when applied to the seed, to the surrounding soil or to the foliage of the emerging plant. Because of the similarity in the carbon, nitrogen, oxygen structure of these reaction products with many biological compounds, it is believed that the reaction products of the present invention may find use in a variety of biological applications.Type: GrantFiled: February 29, 2000Date of Patent: September 10, 2002Assignee: Stoller Enterprises, Inc.Inventor: Frank William Dean
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Patent number: 6426414Abstract: The present invention relates to water dispersible polyisocyanate mixtures prepared from aliphatic, cycloaliphatic, araliphatic and/or aromatic diisocyanates and having a) an average isocyanate functionality of at least 2.0, b) a content of 5.0 to 25.0 wt. %, based on resin solids, of isocyanate groups (calculated as NCO; molecular weight=42) and c) a content of 2 to 50 wt. %, based on resin solids, of ethylene oxide units calculated as C2H2O; molecular weight 44) incorporated within polyether chains containing an average of 5 to 35 ethylene oxide units, wherein at least 60 mole % of the polyether chains are connected via allophanate groups to two polyisocyanate molecules which are each prepared from at least two diisocyanate molecules. The present invention also relates to a process for the preparation of these water dispersible polyisocyanate.Type: GrantFiled: May 14, 1999Date of Patent: July 30, 2002Assignee: Bayer AktiengesellschaftInventors: Hans-Josef Laas, Reinhard Halpaap, Christian Wamprecht
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Patent number: 6420508Abstract: The present invention relates to polyisocyanate mixtures prepared from aliphatic and/or cycloaliphatic diisocyanates and having a) an average isocyanate functionality of at least 2.0, b) a content of isocyanate groups (calculated as NCO; molecular weight=42) of 4.0 to 28.0 wt. % and c) a content of alkoxy groups having up to 36 carbon atoms of 2.0 to 37.5 wt. %, wherein the alkoxy groups are constituents of allophanate groups or optionally urethane groups, provided that >50 mol % of the alkoxy groups are a constituent of allophanate groups that are connected to at least two polyisocyanate molecules which are each prepared from at least two diisocyanates. The present invention also relates to a process for preparing these polyisocyanate mixtures and to coating compositions, which are highly diluted or dilutable with non-polar solvents and contain these polyisocyanate mixtures and lacquer binders or binder components optionally containing isocyanate-reactive groups.Type: GrantFiled: June 8, 2000Date of Patent: July 16, 2002Assignee: Bayer AktiengesellschaftInventors: Karsten Danielmeier, Lutz Schmalstieg, Hans-Josef Laas, Harald Mertes, Reinhard Jahn
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Patent number: 6353134Abstract: The present invention relates to the use of diureides of dicarboxylic acids of the formula I in which R is hydrogen or SO2OM⊕, M is lithium, sodium, potassium, cesium, ammonium, copper, silver, 0.5 iron, 0.5 calcium, 0.5 magnesium, 0.5 manganese, 0.5 zinc or 0.5 cobalt and X is a saturated or monounsaturated, straight-chain or branched C1-to C8-alkyl which may be interrupted by oxygen or NH and which may have attached to it C1-to C4-alkoxy, hydroxyl and/or amino groups, as slow-release fertilizers and to novel diureides of the formula Ia in which R is SO2OM⊕ M is lithium, sodium, potassium, cesium, ammonium, copper, silver, 0.5 iron, 0.5 calcium, 0.5 magnesium, 0.5 manganese, 0.5 zinc or 0.5 cobalt and n is 1,2,3 or 4, and a process for their preparation.Type: GrantFiled: February 29, 2000Date of Patent: March 5, 2002Assignee: BASF AktiengesellschaftInventors: Klaus Horchler von Locquenghien, Klaus Erhardt, Wolfgang Weigelt, Jürgen Dressel, Alexander Wissemeier, Frank Boerner, Gerhard Kossmehl
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Publication number: 20010034429Abstract: Polyisocyanates of the formula (I) (polyisocyanate I),Type: ApplicationFiled: January 26, 2001Publication date: October 25, 2001Applicant: BASF AktiengesellschaftInventors: Bernd Bruchmann, Hans Renz, Gunter Mohrhardt, Hubert Baumgart, Simone Bitter
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Patent number: 6303657Abstract: Compounds of the formula (I) wherein R1 and R2 are H, methyl, or ethyl, provided that at least one of R1 or R2 is methyl or ethyl, have unexpected activity against ants. Compounds wherein at least one of R1 and R2 is methyl or ethyl are novel.Type: GrantFiled: November 7, 2000Date of Patent: October 16, 2001Assignee: Dow AgroSciences LLCInventors: Ronald J. Spragia, George W. Johnson, Laura L. Karr, Jeff M. Edwards, Brian M. Schneider
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Patent number: 4964146Abstract: Alignment in X-ray lithography is generally effected in such a manner that the surface of a target mark for alignment formed on a wafer is illuminated with light for alignment through an X-ray mask, and the position of the wafer is detected from the reflected light. On the basis of the finding that the reflected light from the mask, particularly from an absorber formed thereon, greatly degrades the precision and reliability in measurement, the present invention provides a pattern transfer mask provided with a thin film which lowers the reflection factor of the mask the thin film having a thickness set a .lambda./4n (.lambda.:the wavelength of the light for alignment; n: an integer) or an odd-number multiple thereof. Thus, it is advantageously possible to overcome the above-described lowering of precision and reliablity.Type: GrantFiled: March 15, 1989Date of Patent: October 16, 1990Assignee: Hitachi, Ltd.Inventors: Shinji Kuniyoshi, Takeshi Kumura