Oxy Containing Patents (Class 568/442)
-
Publication number: 20100099908Abstract: A novel tris(formylphenyl) according to the following general formula and polynuclear phenol derived therefrom, which are useful as a material for heat resistant materials, material for photosensitive resist compositions, epoxy resin material or hardener, developer or anti-fade agent for thermosensitive recording materials, or sterilizer, fungicide, antioxidant, etc: In the formula, Y represents a hydrogen atom or —R2COOR3 group, R2 represents a monocyclic or condensed cyclic aromatic hydrocarbon group with a carbon atom number of 6 to 15 or an aliphatic hydrocarbon group with a carbon atom number of 1 to 8 that may have in its main chain a monocyclic or condensed cyclic aromatic hydrocarbon group with a carbon atom number of 6 to 15, and R3 represents a hydrogen atom or alkyl group with a carbon atom number of 1 to 6. R1s may be the same or different and respectively represent a hydrogen atom, alkyl group with a carbon atom number of 1 to 8 or alkoxyl group with a carbon atom number of 1 to 8.Type: ApplicationFiled: June 11, 2007Publication date: April 22, 2010Applicant: Honshu Chemical Industry Co., Ltd.Inventors: Akira Yoshitomo, Tatsuya Iwai
-
Publication number: 20090326263Abstract: Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.Type: ApplicationFiled: June 15, 2009Publication date: December 31, 2009Inventors: Ramakrishnan Chidambaram, Joydeep Kant, Raymond E. Weaver, Jurong Yu, Arun Ghosh
-
Publication number: 20090325972Abstract: Disclosed herein are a novel cinnamaldehyde compound represented by Chemical Formula 1 or pharmaceutically acceptable salts thereof. The cinnamaldehyde compound has improved solubility in water and has inhibitory effects on the growth of cancer cells because it induces cell cycle arrest and cell death. Also disclosed are a method of preparing the cinnamaldehyde compound and an anticancer composition including the compound of Chemical Formula 1.Type: ApplicationFiled: August 28, 2008Publication date: December 31, 2009Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Byoung Mog KWON, Dong Cho HAN, Hye Nan KIM, Young Min HAN, Dae Seop SHIN, Yeong Rim Kang
-
Publication number: 20090314184Abstract: A composition for reducing undesirable odors emitted by hydrocarbonaceous materials is provided. The composition contains at least one aldehyde-containing compound and, optionally, one or more ketone-containing compound and/or a carrier. The composition is free of ester-containing compounds. In at least one exemplary embodiment, the composition contains one or more aldehyde-containing compounds and a liquid carrier. The aldehyde-containing compound(s) has a molecular weight greater than 100 daltons and may be chosen from vanillin or cinnamaldehyde. The ketone-containing compound(s) has a molecular weight greater than 100 daltons, and in exemplary embodiments, from about 120 to about 1,000 daltons. Undesirable odors from hot asphalt are reduced by the composition without adversely affecting the physical and performance properties of the asphalt or decreasing the flash point of the asphalt.Type: ApplicationFiled: December 24, 2008Publication date: December 24, 2009Applicant: Owens Corning Intellectual Capital, LLCInventors: Robert E. Quinn, Jay W. Keating
-
Patent number: 7586009Abstract: Provide a new bis-(hydroxybenzaldehyde) compound, as well as a new polynuclear polyphenol compound derived therefrom, suitable for use as component materials for photosensitive resist compositions, component materials and hardeners for epoxy resins, developers and anti-fading agents used in thermosensitive recording materials, bactericides, fungicides, antioxidants and other functional chemical products or component materials thereof, wherein such bis-(hydroxybenzaldehyde) compound is produced by reacting in the presence of trihalogenated acetic acid catalyst or phosphoric acid catalyst a 2,6-di(hydroxymethyl)-4-alkylphenol with a hydroxybenzaldehyde expressed by general formula (14).Type: GrantFiled: February 23, 2006Date of Patent: September 8, 2009Assignee: Honshu Chemical Industry Co., Ltd.Inventors: Akira Yoshitomo, Tatsuya Iwai
-
Publication number: 20090182168Abstract: 1-Fluoro-2-substituted-3-chlorobenzenes are selectively deprotonated and functionalized in the position adjacent to the fluoro substituent.Type: ApplicationFiled: January 8, 2009Publication date: July 16, 2009Applicant: Dow AgroSciences LLCInventors: Kim E. Arndt, Mark V.M. Emonds, James M. Renga, Jossian Oppenheimer
-
Publication number: 20090182175Abstract: Produce the target substance, or a polynuclear poly(formylphenol) expressed by General Formula (2), in an industrial setting with ease and at high purity by causing a polynuclear poly(hydroxymethylphenol) or polynuclear poly(alkoxymethylphenol) to react with hexamethylene tetramine in the presence of an acid and then hydrolyzing the obtained reaction product.Type: ApplicationFiled: May 31, 2007Publication date: July 16, 2009Inventors: Akira Yoshitomo, Tatsuya Iwai, Kentaro Watanabe
-
Publication number: 20090143593Abstract: Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: February 12, 2009Publication date: June 4, 2009Applicant: FOREST LABORATORIES HOLDINGS LIMITEDInventors: Gian-Luca Araldi, Melanie Ronsheim, Nhut Diep, Shao Hong Zhou
-
Publication number: 20090099061Abstract: A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.Type: ApplicationFiled: May 13, 2008Publication date: April 16, 2009Inventors: Bente J. Foss, Geoffry T. Nadolski, Samuel F. Lockwood
-
Publication number: 20090076310Abstract: Provide a new bis-(hydroxybenzaldehyde) compound, as well as a new polynuclear polyphenol compound derived therefrom, suitable for use as component materials for photosensitive resist compositions, component materials and hardeners for epoxy resins, developers and anti-fading agents used in thermosensitive recording materials, bactericides, fungicides, antioxidants and other functional chemical products or component materials thereof, wherein such bis-(hydroxybenzaldehyde) compound is produced by reacting in the presence of trihalogenated acetic acid catalyst or phosphoric acid catalyst a 2,6-di(hydroxymethyl)-4-alkylphenol with a hydroxybenzaldehyde expressed by general formula (14).Type: ApplicationFiled: February 23, 2006Publication date: March 19, 2009Inventors: Akira Yoshitomo, Tatsuya Iwai
-
Publication number: 20090042957Abstract: The invention relates to compounds of the formula (I) in which A1, A2, R1, R2, R3, R4, R5 and Y are as defined in the description, to processes and intermediates for their preparation and to their use for controlling pests.Type: ApplicationFiled: December 21, 2005Publication date: February 12, 2009Applicant: Bayer CropScience AGInventors: Peter Jeschke, Michael Muller, Iris Escher, Michael E. Beck, Oliver Gaertzen, Olga Malsam, Karl-Josef Haack
-
Patent number: 7473805Abstract: The process comprises reacting a compound of formula (II), where R is a hydroxyl protecting group, and the asterisk indicates an asymmetric carbon atom, with diisopropylamine in the presence of a reducing agent; optionally converting the resulting intermediate into a salt and, if so desired, isolating it; removing the hydroxyl protecting group; and if so desired, separating the desired (R) or (S) enantiomer, or the mixture of enantiomers and/or converting the obtained compound into a pharmaceutically acceptable salt thereof. Tolterodine is a muscarinic receptor antagonist useful in treating urinary incontinence and other symptoms of urinary bladder hyperactivity.Type: GrantFiled: December 21, 2004Date of Patent: January 6, 2009Assignee: Ragactives, S.L. Parque Tecnologico de BoecilloInventors: Gustavo Pascual Coca, Pablo Martin Pascual, Jorge Martin Juarez
-
Publication number: 20080071869Abstract: A system and method for preempting a user's activity state in instant messaging (IM). The system includes a server node configured to administer an IM application. At least one client node is operably associated via a network to the server node. The at least one client node is configured to receive and transmit instant messages via the IM application. The client node permits a user to do at least one of, (i) enable a user about to go offline alert signal or (ii) disable a previously set user about to go offline alert signal.Type: ApplicationFiled: September 20, 2006Publication date: March 20, 2008Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Cynthia E. Barber-Mingo, Cora Clerkin, Gary Denner, Patrick J O'Sullivan, Sonya Purcell
-
Patent number: 7291649Abstract: Methods of forming germicidal aromatic dialdehydes by hydrolyzing acetals are disclosed. Compositions and kits including both germicidal aromatic dialdehydes and acetals that are capable of being converted to germicides are disclosed. In one aspect, an acetal may be converted to germicide gradually in a deployed germicidal solution to accommodate for loss of the germicide or otherwise to modify the germicidal efficacy of the deployed germicidal solution.Type: GrantFiled: June 29, 2005Date of Patent: November 6, 2007Assignee: Ethicon, Inc.Inventors: Peter C. Zhu, Bobby N. Brewer, Kaitao Lu
-
Patent number: 7169950Abstract: The invention relates to a method for producing monocarbonyl compounds or biscarbonyl compounds or hydroxyl compounds by ozonizing, unsaturated organic carbon compounds that, per molecule, have one or more olefinic or aromatic double bonds, which can be cleaved by ozone, and by subsequently processing the ozonization products.Type: GrantFiled: February 13, 2002Date of Patent: January 30, 2007Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KGInventors: Alexander Sajtos, Engelbert Kloimstein, Curt Zimmermann
-
Patent number: 7109381Abstract: Aldehydes containing a difluorooxymethylene bridge, of the general formula I OHC-(A11)m-Z11-(A12-Z12)n-(A13-Z13)p-A14I and the use and preparation thereof and the preparation of 1,3-dioxane compounds.Type: GrantFiled: May 27, 2004Date of Patent: September 19, 2006Assignee: Merck Patent GmbHInventors: Eike Poetsch, Werner Binder, Volker Meyer, Stephan Gürtler, Juergen Eckstein, Michael Schwarz
-
Patent number: 6903239Abstract: The present invention relates to fluorinated benzaldehydes, to a process for preparing them and also to the use of the fluorinated benzaldehydes for preparing active ingredients, especially in medicaments and agrochemicals.Type: GrantFiled: November 21, 2003Date of Patent: June 7, 2005Assignee: Bayer Chemical AktiengesellschaftInventors: Karen Peilstöcker, Albrecht Marhold
-
Patent number: 6891069Abstract: Disclosed herein are methods of synthesizing a 4-substituted-benzene-1,2-carbaldehyde. In one aspect, a method may include reacting a 4-substituted-1,2-bis(dibromomethyl) benzene with sulfuric acid to form a reaction product, introducing a solid sodium bicarbonate into the reaction product, and hydrolyzing the reaction product to form a 4-substituted-benzene-1,2-carbaldehyde, after introducing the bicarbonate.Type: GrantFiled: January 30, 2004Date of Patent: May 10, 2005Assignee: Ethicon, Inc.Inventors: Peter C. Zhu, Der-Haw Wang
-
Publication number: 20040254196Abstract: The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.Type: ApplicationFiled: May 28, 2004Publication date: December 16, 2004Inventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong Cho Han, Sangku Lee, Jong Han Kim, Sung-Gyu Choi, Mi-Young Lee, Sun Bok Jeon
-
Patent number: 6800659Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.Type: GrantFiled: April 12, 2001Date of Patent: October 5, 2004Assignee: HSC Research and Development Limited PartnershipInventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe
-
Publication number: 20040176472Abstract: The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.Type: ApplicationFiled: March 10, 2004Publication date: September 9, 2004Applicant: Ajinomoto Co., Inc.Inventors: Kazutaka Nagashima, Yuuichi Aoki, Tadashi Takemoto, Nao Funakoshi, Eriko Ono
-
Publication number: 20030199714Abstract: The present invention recites a process for the of 2,5-dimethoxy-benzaldehyde by reacting a 2-hydroxy-5 methoxy-benzaldehyde with a suitable metal hydroxide in the presence of a suitable solvent to make a metal salt of 2-hydroxy-5-methoxy benzaldehyde comprising. The invention further provides a method for alkylating said metal salts with dimethylsulfate in the presence of a suitable solvent so as to provide a 2,5-dimethoxy benzaldehyde.Type: ApplicationFiled: April 18, 2002Publication date: October 23, 2003Inventors: Thomas Elbert Shanks, Robert Joseph Maleski
-
Patent number: 6624331Abstract: A process for producing benzyloxyacetaldehyde which comprises oxidizing 2-benzyloxyethanol with hypochlorous acid in the presence of a nitroxy radical having the general formula (I) wherein R represents a hydrogen atom, an acyloxy group, an alkoxyl group or an aralkyloxy group.Type: GrantFiled: September 27, 2001Date of Patent: September 23, 2003Assignee: Kuraray Co., Ltd.Inventors: Masahiro Torihara, Kensuke Nagashima, Koichi Kanehira, Yoshin Tamai
-
Patent number: 6589921Abstract: Compounds of the formula: in which the dotted lines indicate the position of single or double bonds, R1 represents a radical belonging to a fragrant alcohol of the formula R1OH, X represents a nucleophilic group selected from the group consisting of —OH, ═O, —NH2 or —NHR3, R3 representing a C1 to C6 straight-chain or branched hydrocarbon radical, saturated or unsaturated, or an aliphatic or aromatic ring having 5 or 6 carbon atoms, m and n define whole numbers within the range 0 to 2 such that the sum m+n is equal to 1 or 2, p defines a whole number with a value of 0 or 1, each of the symbols R2, R4, R5, R6, R7, taken independently, represents a hydrogen atom, a C1 to C4 straight-chain or branched hydrocarbon radical, saturated or unsaturated optionally substituted, and, taken two by two, they can form aromatic or aliphatic monocyclic, bicyclic or tricyclic substances with the carbon atoms to which they are bound.Type: GrantFiled: April 2, 2002Date of Patent: July 8, 2003Assignee: Firmenich SAInventors: Andreas Herrmann, Jean-Yves Billard De Saint-Laumer, Otto Gräther
-
Patent number: 6590127Abstract: The present invention relates to a process for the preparation of high purity and yield &agr;-asarone, trans 2,4,5-trimethoxy cinnamaldehyde, 2,4,5-trimethoxy-phenyl propionone, from &bgr;-asarone or &bgr;-asarone rich Acorus calamus oil containing &agr; and &ggr;-asarone by hydrogenating, followed by treatment with DDQ with or without solid support of silica gel or alumina in dry organic solvent and &agr;-asarone can also be obtained by treating the hydrogenated product of &bgr;-asarone or &bgr;-asarone rich Acorus calamus with DDQ in an aqueous organic solvent to obtain an intermediate 2,4,5-trimethoxy phenyl propionone, which in turn is reduced with sodiumborohydride to obtain the corresponding 2,4,5-trimethoxy-phenyl propanol and followed by final treatment with a dehydrating agent.Type: GrantFiled: March 28, 2002Date of Patent: July 8, 2003Assignee: Council of Scientific & Industrial ResearchInventors: Arun Kumar Sinha, Bhupendra Prasad Joshi, Ruchi Acharya
-
Patent number: 6509507Abstract: A process for preparing polymerizable biaryl derivatives comprises reacting an aromatic comprising a 6-membered ring which bears ester or benzylic OH groups in the 1,4 position with a second aromatic in a palladium-catalyzed cross-coupling reaction to give a biaryl and converting the ester or benzylic OH groups into polymerizable groups in one or more steps. The biaryls obtained are suitable for preparing polymers which are used as electroluminescence materials.Type: GrantFiled: October 16, 2001Date of Patent: January 21, 2003Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Hubert Spreitzer, Willi Kreuder, Heinrich Becker, Jochen Krause
-
Patent number: 6420610Abstract: Aromatic aldehyde compounds of formula (4) and (6) are disclosed, wherein Y is a methylene group with various substitutions and R represents various substituents.Type: GrantFiled: September 13, 2000Date of Patent: July 16, 2002Assignee: Fuji Photo Film Co., Ltd.Inventors: Takashi Nakamura, Toshiyuki Makuta, Koki Nakamura
-
Patent number: 6384273Abstract: The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one alkaline metal in the presence of a compound of formula (I): RX, wherein: R represents a hydrocarbon radical having 1 to 20 carbon atoms which can be a saturated or unsaturated, linear or branched, acyclic aliphatic radical; a saturated or unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical bearing a cyclic substituent; and X represents a bromine or chlorine atom.Type: GrantFiled: January 24, 2001Date of Patent: May 7, 2002Assignee: Rhodia ChimieInventors: Virginie Pevere, Jean Roger Desmurs, Charles Mioskowski, Alain Wagner, Arnaud Gissot
-
Patent number: 6326397Abstract: The present invention relates to novel retinoid antagonists of the formula I wherein the dotted bond can be either hydrogenated or form a double bond; and, when the dotted bond forms a double bond, R1 is lower alkyl and R2 is hydrogen; and, when the dotted bond is hydrogenated, R1 and R2 taken together are methylene to form a cis-substituted cyclopropyl ring; R3 is hydroxy or lower alkoxy; R4 is alkyl or alkoxy; and R5 and R6 are, independently, a C4-12 alkyl or a 5-12 cycloalkyl substituent containing from 1-3 rings which are either unsubstituted or substituted with from 1-3 lower alkyl groups, with the carbon atom of R5 and R6 being linked to the remainder of the molecule to form a quaternary carbon atom pharmaceutically acceptable salts of carbocylic acids of the formula I; as well as method for the treatment of osteoporosis and preneoplastic and neoplastic diseases, and a method for reducing or abolishing adverse events in subjects receiving retinoid agonist treatment by administering aType: GrantFiled: May 7, 1999Date of Patent: December 4, 2001Assignee: Hoffman-La Roche Inc.Inventors: Werner Bollag, Michael Klaus, Peter Mohr, Paola Panina-Bordignon, Michael Rosenberger, Francesco Sinigaglia
-
Patent number: 6323373Abstract: A process for preparing polymerizable biaryl derivatives comprises reacting an aromatic comprising a 6-membered ring which bears ester or benzylic OH groups in the 1,4 position with a second aromatic in a palladium-catalyzed cross-coupling reaction to give a biaryl and converting the ester or benzylic OH groups into polymerizable groups in one or more steps. The biaryls obtained are suitable for preparing polymers which are used as electroluminescence materials.Type: GrantFiled: June 9, 1999Date of Patent: November 27, 2001Assignee: Aventis Research & Technologies GmbH & Co. KGInventors: Hubert Spreitzer, Willi Kreuder, Heinrich Becker, Jochen Krause
-
Patent number: 6288126Abstract: A compound having the formula wherein R5 is an [A]—CH3, —[A]—C(OH)ZZ′ or —[A]—C(O)Z″ grouping where —[A]— is an alkylene, alkenylene or alkynylene radical or a single bond, and Z, Z′ and Z″ are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl radical; and R1, R2, R3, R4, R6, R7 and R8 are as defined in the description; the use thereof as a drug, pharmaceutical compositions containing same, a preparation method therefor, and intermediates of said method, are disclosed.Type: GrantFiled: September 28, 1998Date of Patent: September 11, 2001Assignee: Aventis Pharma S.A.Inventors: Dominique Lesuisse, Jean-Georges Teutsch
-
Patent number: 6288262Abstract: 2-Methoxyethoxy-benzenes are obtained in an advantageous manner from the corresponding phenol compounds by reaction with 2-chloroethyl methyl ether if the process is carried out without the addition of a strong solvent at temperatures above 95° C. and under pressure. The present invention also relates to novel 2-methoxyethoxybenzyl cyanides.Type: GrantFiled: January 30, 2001Date of Patent: September 11, 2001Assignee: Bayer AktiengesellschaftInventors: Guido Giffels, Claus Dreisbach
-
Patent number: 6184421Abstract: The present invention concerns a process for the preparation of a 4-hydroxybenzaldehyde and its derivatives. More particularly, the invention concerns the preparation of 3-methoxy-4-hydroxybenzaldehyde and 3-ethoxy-4-hydroxybenzaldehyde, respectively known as vanillin and ethylvanillin.Type: GrantFiled: May 13, 1999Date of Patent: February 6, 2001Assignee: Rhodia ChimieInventor: Pascal Metivier
-
Patent number: 6162445Abstract: Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.Type: GrantFiled: October 6, 1997Date of Patent: December 19, 2000Assignee: Centre International de Recherches Dermatologiques GaldermaInventor: Jean-Michel Bernardon
-
Patent number: 6147224Abstract: Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR.sub.1 R.sub.1).sub.n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent aryl or 5 or 6 membered heteroaryl radical having 1 to 3 heteroatoms selected from N, S and O, said aryl or heteroaryl groups being unsubstituted, or substituted with 1 to 3 C.sub.1-6 alkyl or with 1 to 3 C.sub.1-6 fluoroalkyl groups; and the remaining symbols have the meaning described in the specification, have RXR selective retinoid agonist-like activity.Type: GrantFiled: October 1, 1998Date of Patent: November 14, 2000Assignee: Allergan Sales, Inc.Inventors: Vidyasagar Vuligonda, Kwok Yin Tsang, Jayasree Vasudevan, Roshantha A. Chandraratna
-
Dihalopropene compounds, their use as insecticides/acaricides and intermediates for their production
Patent number: 6140274Abstract: Dihalopropene compounds of the general formula: ##STR1## wherein R.sup.1 is substituted alkyl; R.sup.2, R.sup.3 and R.sup.4 are each independently halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro or cyano; A is O, S(O).sub.t or NR.sup.14 in which R.sup.14 is H or alkyl and t is 0 to 2; B is substituted alkylene, alkenylene or alkynylene; r is 0 to 2; X's are each independently halogen; Y is O, S or NH; Z is O, S or NR.sup.25 in which R.sup.25 is H, acetyl or alkyl, which are useful as active ingredients of insecticidal/acaricidal agents.Type: GrantFiled: June 12, 1998Date of Patent: October 31, 2000Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroshi Ikegami, Keiichi Izumi, Masaya Suzuki, Noriyasu Sakamoto, Hirotaka Takano -
Patent number: 6084134Abstract: 9-Anthracenecarbaldehydes are obtained in a particularly advantageous manner by reacting the corresponding anthracene derivatives with dimethylformamide in the presence of phosphoryl chloride, hydrolyzing the resulting reaction mixture and precipitating the 9-anthracenecarbaldehyde that is formed by admixing a base.Type: GrantFiled: March 27, 1998Date of Patent: July 4, 2000Assignee: Bayer AktiengesellschaftInventor: Wolfram Eichinger
-
Patent number: 5866723Abstract: The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.Type: GrantFiled: June 27, 1996Date of Patent: February 2, 1999Assignee: Monsanto CompanyInventors: Bruce C. Hamper, Kindrick L. Leschinsky
-
Patent number: 5783737Abstract: The present invention concerns a process for the preparation of 3-carboxy-4-hydroxybenzaldehydes and derivatives thereof from phenolic compounds carrying formyl and/or hydroxymethyl groups in the 2 and 4 positions.The invention also concerns the preparation of 4-hydroxybenzaldehydes from 3-carboxy-4-hydroxybenzaldehydes.More particularly, the invention concerns the preparation of 3-methoxy-4-hydroxybenzaldehyde and 3-ethoxy-4-hydroxybenzaldehyde, respectively known as "vanillin" and "ethylvanillin".The process for the preparation of 3-carboxy-4-hydroxybenzaldehyde is characterized in that the group in the 2 position in a phenolic compound carrying formyl and/or hydroxymethyl groups in the 2 and 4 positions is selectively oxidized to a carboxy group, and optionally a hydroxymethyl group in the 4 position is selectively oxidized to a formyl group.A successive decarboxylation step for a 3-carboxy-4-hydroxybenzaldehyde produces a 4-hydroxybenzaldehyde.Type: GrantFiled: January 24, 1997Date of Patent: July 21, 1998Assignee: Rhone-Poulenc ChimieInventor: Pascal Metivier
-
Patent number: 5698744Abstract: Selective oxidation employs ferromagnetic chromium dioxide followed by magnetic separation.Type: GrantFiled: March 31, 1995Date of Patent: December 16, 1997Assignee: E. I. Du Pont de Nemours and CompanyInventor: Ross Albert Lee
-
Patent number: 5656619Abstract: Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.Type: GrantFiled: June 6, 1995Date of Patent: August 12, 1997Assignee: BASF AktiengesellschaftInventors: Bernd Janssen, Hans-Heiner Wuest
-
Patent number: 5654331Abstract: Diaromatic compounds, characterised in that they correspond to the following general formula: ##STR1## in which: R.sub.1 is --CH.sub.3, --CH.sub.2 OH, --COR.sub.8 or --CH.sub.2 OCOR.sub.9, R.sub.8 is H, OH, --OR.sub.10, --N(rr') or alkyl, R.sub.10 is alkyl, alkenyl, aryl or aralkyl, r and r' being H, alkyl, aryl, aralkyl, etc., r and r' together form a heterocycle, R.sub.9 is alkyl, alkenyl or a sugar residue, R.sub.2 and R.sub.3 are --OR.sub.11 or --OCOR.sub.11, R.sub.11 is H, alkyl, fluoroalkyl, aryl or aralkyl, R.sub.3 in addition being H, R.sub.4 is H, OH, alkyl, alkoxy, F, Cl or --CF.sub.3, R.sub.5 and R.sub.7 are H, OH, alkoxy, .alpha.-substituted alkyl or .alpha.,.alpha.'-disubstituted alkyl, etc., R.sub.6 is H, OH, alkyl, alkoxy, cycloalkyl, etc., R.sub.5 and R.sub.7 cannot simultaneously be OH or alkoxy and R.sub.4, R.sub.5, R.sub.6 and R.sub.7 cannot simultaneously be H, R.sub.5 and R.sub.6 or R.sub.6 and R.sub.Type: GrantFiled: May 25, 1995Date of Patent: August 5, 1997Assignee: Centre International De Recherches Dermatologiques Galderma (Cird Galderma)Inventor: Jean-Michel Bernardon
-
Patent number: 5650444Abstract: A compound of the following structure: ##STR1## wherein, when R.sub.8 =H: R.sub.1 =alkyl, cycloalkyl, arylalkyl, aryl;R.sub.2 =cycloalkyl, aryl, C.sub.3 -C.sub.10 alkyl;X,Y=O, S(O).sub.n, NH;Z=CHO, CO.sub.2 R.sub.3, CONHR.sub.4 R.sub.5, CN, COR.sub.6, H, halo, HCN, NHCONR.sub.4 R.sub.5, CONR.sub.4 OR.sub.5, CONR.sub.4 NR.sub.5 R.sub.6, 1-tetrazole, S(O).sub.n OH, S(O).sub.n NR.sub.3 R.sub.4, C.dbd.NOH, C(.dbd.N(OH)NH.sub.2, OCONR.sub.7 R.sub.6, P(O)(OR.sub.4).sub.2, C(.dbd.N(YR.sub.3))R.sub.4, NH.sub.2, SH, OH, OS(O).sub.2 R.sub.3, C(.dbd.NYC(.dbd.O)R.sub.3)R.sub.4, C(O)CO.sub.2 R.sub.3, C(O)CONR.sub.3 R.sub.4, CH(OH)CO.sub.2 R.sub.3, CHFCO.sub.2 R.sub.3, CF.sub.2 CO.sub.2 R.sub.3, CH(OH)CONR.sub.3 R.sub.4, CF.sub.2 CONR.sub.3 R.sub.4, C.dbd.NNH.sub.2, C(.dbd.NOC(.dbd.O)R.sub.3)R.sub.4, C(.dbd.NNHC(.dbd.O)R.sub.3)R.sub.4, C(.dbd.NOH)R.sub.3, C(.dbd.NNR.sub.3)R.sub.4, NHC(.dbd.O)R.sub.6 or C(O)CONH.sub.2 ;R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.Type: GrantFiled: May 25, 1995Date of Patent: July 22, 1997Assignee: American Home Products CorporationInventors: Thomas J. Caggiano, Joseph Prol, Jr.
-
Patent number: 5648387Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.Type: GrantFiled: March 24, 1995Date of Patent: July 15, 1997Assignee: Warner-Lambert CompanyInventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
-
Patent number: 5612479Abstract: Novel polycyanate compositions containing one or more mesogenic moieties as lateral substituents are disclosed which provide improved processability relative to polycyanates containing one or more mesogenic moieties in the main chain of the molecule. Molecular level ordering of the resulting thermosets is maintained much similar to that found thermosets of polycyanates which have one or more mesogenic moieties in the main chain.Type: GrantFiled: August 17, 1994Date of Patent: March 18, 1997Assignee: The Dow Chemical CompanyInventors: Robert E. Hefner, Jr., Jimmy D. Earls
-
Patent number: 5606089Abstract: Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring.Type: GrantFiled: May 18, 1995Date of Patent: February 25, 1997Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Yoshiaki Kato, Mitsutaka Yoshida, Osamu Cynshi, Yasuhiro Ohba
-
Patent number: 5599975Abstract: A compound selected from those of formula (I): ##STR1## wherein A, X, Y, Z, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description.This compound or its physiologically tolerable salts may be used therapeutically as platelet anti-aggregation agent.Type: GrantFiled: October 27, 1994Date of Patent: February 4, 1997Assignee: Adir Et CompagnieInventors: Ren e Gree, Ali M. Hachem, Danielle Gree, Yves Le Floc'h, Yves Rolland, Serge Simonet, Tony Verbeuren
-
Patent number: 5599952Abstract: Methods of producing carboxylic acid ester derivatives of formulae (I) and (II), which are useful, for instance, as intermediates for producing an anti-hypercholesterolemic agent having an inhibitory effect on HMG-CoA Reductase: ##STR1## wherein R.sup.1 and R.sup.2 are independently a protective group for hydroxyl group, or R.sup.1 and R.sup.2 integrally constitute a protective group for hydroxyl groups; R.sup.3 is an alkyl group, or an aryl group; and R.sup.4 is a substituted aryl group, a substituted heterocyclic group, a substituted vinyl group, or a substituted cycloalkenyl group; and ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are respectively the same as defined in the above formula (I), are disclosed. In addition, intermediates for use in these methods of producing the carboxylic acid ester derivatives are disclosed.Type: GrantFiled: May 18, 1995Date of Patent: February 4, 1997Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Eiko Mori, Hisako Kobayashi, Hiroshi Ikawa
-
Patent number: 5591884Abstract: Novel compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, whereinA is --O--, --S-- or --CR.sup.2 R.sup.8 --;R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, X and Y are specifically defined; andup to one combination of (a) R.sup.2 and R.sup.5, (b) R.sup.5 and R.sup.6, (c) R.sup.5 and R.sup.7, (d) R.sup.6 and R.sup.7, and (e) R.sup.7 and Y, taken together with the atoms to which they are attached, may form a ring, the compounds being useful for treating dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of cognitive impairment, attention deficit disorder, and substance abuse and other addictive behavior disorders.Also disclosed are intermediates and processes useful in the preparation of the above compounds.Type: GrantFiled: June 5, 1995Date of Patent: January 7, 1997Assignee: Abbott LaboratoriesInventors: Michael P. DeNinno, Richard J. Perner
-
Patent number: 5563161Abstract: Compounds of formula (I), and salt and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; R.sup.1 is H; optionally substituted C.sub.1-6 alkyl; optionally substituted phenyl(C.sub.1-4 alkyl); C.sub.2-6 alkenyl; C.sub.2-6 alkynyl; COR.sup.a ; COOR.sup.a ; COHet; COC.sub.1-6 alkylhalo; COC.sub.1-6 alkylNR.sup.a R.sup.b ; CONR.sup.12 C.sub.1-6 alkylCONR.sup.a R.sup.b ; CONR.sup.a R.sup.b ; or SO.sub.2 R.sup.a ; R.sup.2 represents H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; or R.sup.1 and R.sup.2 together form a chain (CH.sub.2).sub.q optionally substituted by oxo where q is 4 or 5 and where one methylene group may optionally be replaced by an oxygen atom or a group NR.sup.x, where R.sup.x is H or C.sub.1-6 alkyl; R.sup.3 is C.sub.1-3 alkyl substituted by optionally substituted phenyl; R.sup.4 and R.sup.5 are each H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; and Z represents O or S; are tachykinin receptor antagonists useful in therapy.Type: GrantFiled: March 10, 1995Date of Patent: October 8, 1996Assignee: Merck Sharp & Dohme Ltd.Inventors: Ian T. Huscroft, Graeme I. Stevenson, Brain J. Williams