Polycyclo-alicyclic Ring System Patents (Class 568/941)
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Patent number: 8586810Abstract: The present invention proposes a chiral diene ligand, a fabrication method thereof and applications thereof. The chiral diene ligand is a bicyclo[2.2.1] diene ligand having structural specificity and high stability, which favors the bicyclo[2.2.1] diene ligand to take part in asymmetric transformations, particularly an asymmetric addition reaction involving a metal catalyst in a basic environment. Most of the products of the reactions implemented by the chiral diene ligands of the present invention have superior optical activity. The method of the present invention comprises a first oxidation step, a saponification step, a second oxidation step, a deprotonation step, and a cross-coupling step. The chiral diene ligand of the present invention is very suitable to be used in the fabrication or synthesis of various chemicals and medical products.Type: GrantFiled: September 10, 2012Date of Patent: November 19, 2013Assignee: National Taiwan Normal UniversityInventors: Hsyueh-Liang Wu, Chun-Chih Chen, Chia-Chen Liu, Wei-Ting Wei, Jo-Hsuan Fang
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Publication number: 20110082053Abstract: Provided is a molecular rectifier comprised of a diamondoid molecule and an electron acceptor attached to the diamondoid molecule. The electron acceptor is generally an electron accepting aromatic species which is covalently attached to the diamondoid.Type: ApplicationFiled: January 30, 2009Publication date: April 7, 2011Inventors: Wanli Yang, Zhi-Xun Shen, Harindran C. Manoharan, Nicholas A. Melosh, Michael A. Kelly, Andrey A. Fokin, Peter R. Schreiner, Jason C. Randel
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Publication number: 20110040092Abstract: The invention relates to a process for making HOF.RCN and using it to oxidise organic substrates in a quick and safe way. The process comprises passing diluted fluorine through a conduit and RCN in water through another conduit into a microreactor to form HOF.RCN and reacting this with an organic substrates.Type: ApplicationFiled: September 5, 2008Publication date: February 17, 2011Applicant: THE SECRETARY OF STATE FOR DEFENSEInventors: Christopher Murray, Graham Sandford
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Patent number: 7683229Abstract: The present invention relates to novel truxene and isotruxene derivatives, in particular spirotruxene and spiroisotruxene derivatives, and to the use thereof in organic electronic devices, in particular organic electroluminescent devices.Type: GrantFiled: July 15, 2005Date of Patent: March 23, 2010Assignee: Merck Patent GmbHInventors: Philipp Stoessel, Esther Breuning, Liliana Bagala′ Rampazzo, Giulia Fioravanti, Leonardo Mattiello
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Patent number: 7297808Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.Type: GrantFiled: November 1, 2006Date of Patent: November 20, 2007Assignee: Nicox S.A.Inventors: Francesca Benedini, Ennio Ongini, Piero Del Soldato
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Patent number: 6930128Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.Type: GrantFiled: July 10, 2003Date of Patent: August 16, 2005Assignee: The Children's Medical Center CorporationInventors: Robert John D'Amato, Moses Judah Folkman
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Patent number: 5998661Abstract: A process for selective, direct oxidation of amine or amine hydrochloride mpounds is described. It uses mixed oxidizing agents of monopersulfate and ozone.Type: GrantFiled: June 15, 1998Date of Patent: December 7, 1999Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Abdollah Bashir-Hashemi
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Patent number: 5956657Abstract: The method provides nitro compounds at a high conversion and selectivity by nitrating substrates under comparatively mild conditions in the absence of catalysts. Organic substrates are nitrated using no catalysts or ozone, but using (1) at least one nitrogen compound selected from N.sub.2 O or NO and oxygen. It is advantageous for the nitration reaction to employ a nitrogen compound obtained by a reaction of the nitrogen compound with oxygen, particularly a nitrogen oxide comprising N.sub.2 O.sub.3 as a main component. Additionally, organic substrates are nitrated using (2) NO.sub.2. The substrates include a compound having a methine-carbon atom, and a compound having a methyl group or methylene group in an adjacent position to an aromatic ring.Type: GrantFiled: December 23, 1997Date of Patent: September 21, 1999Assignees: Daicel Chemical Industies, Ltd., Yasutaka IshiiInventors: Tatsuya Nakano, Satoshi Sakaguchi, Yasutaka Ishii
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Patent number: 5582955Abstract: Methods for covalently modifying surfaces of various substrates are disclosed, along with various substrates having surfaces modified by such methods. Candidate surfaces include various polymeric, siliceous, metallic, allotrophic forms of carbon, and semiconductor surfaces. The surfaces are exposed to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The nitrene covalently reacts with any of various chemical groups present on the substrate surface, thereby effecting nitrene addition of the functionalizing groups to the substrate surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface, thereby dramatically altering the chemical behavior of the surface.Type: GrantFiled: June 26, 1995Date of Patent: December 10, 1996Assignee: State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of OregonInventors: John F. W. Keana, Martin N. Wybourne, Sui X. Cai, Mingdi Yan
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Patent number: 5214221Abstract: An efficient direct functionalization of nitrocubanes has been achieved by rradiation of a solution in an oxalyl halide to yield halogenated and halocarbonylated derivatives of nitrocubanes.Type: GrantFiled: October 1, 1992Date of Patent: May 25, 1993Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Abdollah Bashir-Hashemi
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Patent number: 5202508Abstract: 2,2,4,4,6,6-hexamitroadamantane and a method of making the same.Type: GrantFiled: May 4, 1992Date of Patent: April 13, 1993Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Paritosh R. Dave
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Patent number: 5189228Abstract: 3,7,9,9-Tetranitronoradamantane.Type: GrantFiled: June 29, 1992Date of Patent: February 23, 1993Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Walter W. Zajac, Jr.
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Patent number: 5180853Abstract: 4,4,6,6-Tetranitroadamantan-2-one and a method of making the same.Type: GrantFiled: May 4, 1992Date of Patent: January 19, 1993Inventor: Paritosh R. Dave
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Patent number: 5105031Abstract: 3,7,9-Trinitronoradamantane and a method of making the same.Type: GrantFiled: June 17, 1991Date of Patent: April 14, 1992Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Walter W. Zajac, Jr.
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Patent number: 4853151Abstract: Dispirotetradecanes of the formula I ##STR1## wherein R.sup.1 and R.sup.2 are each independently of each other alkyl containing 1 to 12 carbon atoms wherein one or more non-adjacent CH.sub.2 groups may also be replaced by --O--, --CO--, --CO--O--, --O--CO--, --O--COO-- and/or --CH.dbd.CH-- (trans), one of the radicals R.sup.1 and R.sup.2 also being H, F, Cl, Br, I, CN, NO.sub.2, NCS,A.sup.1 and A.sup.2 are each independently of each other trans-1,4-cyclohexylene wherein one or two non-adjacent CH.sub.2 groups may be replaced by --O-- and/or --S--, or 1,4-phenylene wherein one or more CH groups may also be replaced by N, with it also being possible optionally for A.sup.1 and A.sup.2 to be substituted laterally or axially by F, Cl, CN, CH.sub.3,Z.sup.1 and Z.sup.2 are each independently of each other --C--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 -- or a single bond,m and n are each 0, 1 or 2,(m+n) 0, 1 or 2,X.sup.1, X.sup.2, X.sup.3 and X.sup.Type: GrantFiled: August 11, 1987Date of Patent: August 1, 1989Assignee: Merck Patent Gesellschaft Mit Beschrankfter HaftungInventors: Fritz Vogtle, Wolfgang Calaminus
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Patent number: 4535193Abstract: A composition comprising 1,4,6,9-tetranitrodiamantane, and process for its reparation are disclosed.Type: GrantFiled: March 5, 1984Date of Patent: August 13, 1985Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Gilbert P. Sollott, Everett E. Gilbert
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Patent number: 4386007Abstract: Liquid crystalline naphthalene derivatives of the formula ##STR1## wherein ring A is 1,4-phenylene, trans-1,4-cyclohexylene or 1,4-cyclohex-1-enylene and ring system BC is 2,6-naphthylene, 3,4-dihydro-2,6-naphthylene or 1,2,3,4-tetrahydro-2,6-naphthylene, with the proviso that A is not 1,4-phenylene when BC is 2,6-naphthylene; and R.sub.1 and R.sub.2, which are identical or different, are each alkyl of up to 8 C atoms or, when the rings to which they are bonded are aromatic, also can be alkoxy, alkanoyloxy or alkoxycarbonyloxy having up to 8 C atoms in each case; or one of R.sub.1 and R.sub.2 also can be CN, halogen, CF.sub.3 or NO.sub.2 are valuable components for liquid crystalline dielectrics.Type: GrantFiled: December 5, 1980Date of Patent: May 31, 1983Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Joachim Krause, Michael Romer, Ludwig Pohl
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Patent number: 4329522Abstract: The invention provides a novel explosive compound 1,3,5,7-tetranitroadamane, which possesses high explosive energy combined with excellent impact and thermal stability. The novel compound can be prepared by oxidation of 1,3,5,7-tetraaminoadamantane with permanganate.Type: GrantFiled: October 14, 1980Date of Patent: May 11, 1982Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Everett E. Gilbert, Gilbert P. Sollott