Simulation Of Modeling Patents (Class 600/416)
  • Patent number: 8888717
    Abstract: Various methods, techniques or modules are provided to allow for the automated analysis of the 3-D representation of the upper front torso (i) to recognize 3-D anatomical features, (ii) to orient the subject with reference to their anatomy or a display, (iii) to determine dimensional analysis including direct point-to-point lines, 3-D surface lines, and volume values, (iv) to simulate the outcome with the addition of breast implants including breast and nipple positioning, (v) to assist in the selection of the breast implants, and/or (vi) to assist in the planning of breast surgery. The automated analysis is based on the analysis of changes in a 3-D contour map of the upper torso, orientation analysis of 3-D features and planes, color analysis of 3-D features, and/or dimensional analysis of 3-D features and positions of the upper torso.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: November 18, 2014
    Assignee: Allergan, Inc.
    Inventors: David H. Mordaunt, G. Patrick Maxwell, Thomas J. Liolios
  • Publication number: 20140316250
    Abstract: MRI techniques seek to simultaneously measure physiological parameters in multiple directions, requiring the application of multiple encoding magnetic field gradient waveforms. The use of multiple encoding waveforms degrades the temporal resolution of the measurement, or may distort the results depending on the methodology used to derive physiological parameters from the measured data. The disclosed Direct Inversion Reconstruction Method (DiR) provides distortion-free velocity images with high temporal resolution, without changing the method of acquiring the phase data. The disclosed method provides a more stable and accurate recovery of phase-based dynamic magnetic resonance signals with higher temporal resolution than current state-of-the-art methods.
    Type: Application
    Filed: April 22, 2014
    Publication date: October 23, 2014
    Applicant: Ohio State Innovation Foundation
    Inventors: Rizwan Ahmad, Orlando P. Simonetti, Yu Ding, Ning Jin
  • Patent number: 8861815
    Abstract: Systems and methods for modeling functional magnetic resonance image datasets using a multivariate auto-regressive model which captures temporal dynamics in the data, and creates a reduced representation of the dataset representative of functional connectivity of voxels with respect to brain activity. Raw spatio-temporal data is processed using a multivariate auto-regressive model, wherein coefficients in the model with high weights are retained as indices that best describe the full spatio-temporal data. When there are a relatively small number of temporal samples of the data, sparse regression techniques are used to build the model. The model coefficients are used to perform data processing functions such as indexing, prediction, and classification.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: October 14, 2014
    Assignee: International Business Machines Corporation
    Inventors: Guillermo Alberto Cecchi, Rahul Garg, Ravishankar Rao
  • Patent number: 8855984
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: October 7, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Patent number: 8855741
    Abstract: A method of acquiring an image biomarker suitable for prognosis of a blood-related disease, such as acute myeloid leukemia, includes the steps of: (a) acquiring physical parameter sets, each including at least two parameters, respectively from time-signal intensity curves, these curves being respectively obtained from magnetic resonance image sets of different subjects; each of the image sets being acquired through MRI scanning using one of first and second configuration parameter sets; (b) analyzing the physical parameter sets thus acquired and (c) establishing a risk score function that is a sum of products of each of the physical parameters and the corresponding weight value, wherein a risk score obtained using the risk score function serves as the image biomarker suitable for prognosis of the blood-related disease.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 7, 2014
    Assignee: National Taiwan University
    Inventors: Tiffany Ting-Fang Shih, Timothy K. Shih
  • Publication number: 20140296702
    Abstract: Three-dimensional (3D) projections of nuclear magnetic resonance (NMR) signals are acquired from a liver experiencing NMR in response to a 3D multi-echo non-Cartesian pulse sequence. The projections are reconstructed into two sets of images having different resolutions. Bins associated with the different positions to which the liver moves during respiration are identified in lower resolution images, and then higher resolution images are binned into the position dependent bins based on navigator data in the lower resolution images. A combined image for a bin is made from images located in the bin and then registered to a reference image. An overall combined image is made by summing the combined bin images. Quantized data for a contrast agent concentration in the liver is produced using signal intensity in the overall combined image. The quantized value may describe a liver perfusion parameter. A diagnosis may be made from the quantized value.
    Type: Application
    Filed: February 11, 2014
    Publication date: October 2, 2014
    Applicant: Case Western Reserve University
    Inventors: Mark Griswold, Vikas Gulani, Greg Lee, Nicole Seiberlich
  • Patent number: 8834391
    Abstract: Various methods, techniques or modules are provided to allow for the automated analysis of the 3-D representation of the upper front torso (i) to recognize 3-D anatomical features, (ii) to orient the subject with reference to their anatomy or a display, (iii) to determine dimensional analysis including direct point-to-point lines, 3-D surface lines, and volume values, (iv) to simulate the outcome with the addition of breast implants including breast and nipple positioning, (v) to assist in the selection of the breast implants, and/or (vi) to assist in the planning of breast surgery. The automated analysis is based on the analysis of changes in a 3-D contour map of the upper torso, orientation analysis of 3-D features and planes, color analysis of 3-D features, and/or dimensional analysis of 3-D features and positions of the upper torso.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: September 16, 2014
    Assignee: Allergan, Inc.
    Inventors: David H. Mordaunt, G. Patrick Maxwell
  • Patent number: 8812431
    Abstract: A method and system for providing medical decision support based on virtual organ models and learning based discriminative distance functions is disclosed. A patient-specific virtual organ model is generated from medical image data of a patient. One or more similar organ models to the patient-specific organ model are retrieved from a plurality of previously stored virtual organ models using a learned discriminative distance function. The patient-specific valve model can be classified into a first class or a second class based on the previously stored organ models determined to be similar to the patient-specific organ model.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: August 19, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Ingmar Voigt, Dime Vitanovski, Razvan Ioan Ionasec, Alexey Tsymbal, Bogdan Georgescu, Shaohua Kevin Zhou, Martin Huber, Dorin Comaniciu
  • Patent number: 8805048
    Abstract: A method for generating a cephalometric analysis of an orthodontic patient is disclosed. A sequence of images that may each correspond to a specific anatomical plane of the patient is received. Then, a volumetric representation of the patient is derived from a combination of the sequence of the images. One or more markers associated with particular anatomical landmarks of the patient according to a predefined analysis method are received. The markers are defined by a set of coordinate values, and are designated via an interactive user interface to a two-dimensional representation derived from the volumetric representation. Connectors between one or more of the markers are generated in accordance with the predefined analysis method, and a visual representation of the markers and the connectors are overlaid on the volumetric representation.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: August 12, 2014
    Inventor: Mark Batesole
  • Patent number: 8781554
    Abstract: A method for simulating magnetic resonance signals is proposed. A lattice array where each point in the array has several magnetic resonance sensitive particles is provided. Statistic property of each point is set. A raw magnetic resonance imaging data is calculated based on statistic property of each point and a magnetic resonance imaging sequence to be applied. A system for simulating magnetic resonance signals is further proposed. By considering statistic property of each point, it can distinguish every part of the object to be scanned and really reflect the structure of object without using a real magnetic resonance imaging device. It saves time and costs for avoiding several scanning by the real a magnetic resonance imaging device.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: July 15, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Oliver Schreck, Rui Zhang, Shi Gang Zhang, Hai Yan Zhou
  • Patent number: 8774898
    Abstract: The present invention relates to a method of characterising tissue function in a subject in need of such characterization. The method comprises performing an imaging technique, on a voxel defined within a tissue space of interest, wherein image data is generated over a time period during which the subject inhales gases with at least two different partial pressures of a paramagnetic gas. A compartmental model algorithm is applied to the image data generated for the voxel to provide information on metabolic function of the tissue.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: July 8, 2014
    Assignee: BIOxyDyn Limited
    Inventors: Deirdre McGrath, Geoffrey Parker
  • Patent number: 8768669
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: July 1, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Patent number: 8768670
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: July 1, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Publication number: 20140180061
    Abstract: A computerized method of generating a map of myelin tissue of a brain is described. In addition sub-maps of different myelin contents can be imaged. The method uses a simulation model comprising at least two interacting tissue compartments.
    Type: Application
    Filed: October 14, 2010
    Publication date: June 26, 2014
    Inventor: Marcel Warntjes
  • Patent number: 8750583
    Abstract: A method of surgical modeling is disclosed. A set of related two-dimensional (2D) anatomical images is displayed. A plurality of anatomical landmarks is identified on the set of related 2D anatomical images. A three-dimensional (3D) representation of at least one prosthesis is scaled to match a scale of the 2D anatomical images based at least in part on a relationship between the anatomical landmarks. 3D information from the at least one prosthesis along with information based on at least one of the plurality of anatomical landmarks is utilized to create procedure-based information. A system for surgical modeling is also disclosed. The system has a prosthesis knowledge-based information system, a patient anatomical-based information system, a user interface, and a controller. The controller has an anatomical landmark identifier, a prosthesis-to-anatomical-feature relator, and a procedure modeler.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: June 10, 2014
    Assignee: FUJIFILM Medical Systems USA, Inc.
    Inventors: James Andrew Zug, Micah Aaron Forstein, Emil Michael Saraga, Jr.
  • Patent number: 8718747
    Abstract: The invention provides a method, an image analysis software product, and a system for medical imaging analysis for estimating contrast agent extravasation in contrast agent based perfusion imaging such as MRI dynamic contrast enhanced (DCE) imaging, and in particular correction, compensation, or visualization of extravascular leakage of contrast agent in tumors. According to the invention, the effect of extravasation is directly manifested in the tail part of an observed, apparent residue function, R?(t), obtained directly by de-convoluting the expression C(t)=R?(t)Cp?(t) with the arterial input function (AIF). A leakage rate or extravasation constant is determined directly from the tail part of the determined apparent residue function.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: May 6, 2014
    Assignee: Oslo Universitetssykehus HF
    Inventors: Atle Bjørnerud, Kyrre Eeg Emblem
  • Publication number: 20140114178
    Abstract: A computer-implemented method for concurrently estimating the amount of fat and iron in anatomical tissue from magnetic resonance (MR) signal data includes receiving a test signal representative of the anatomical tissue acquired using a MR pulse sequence type. A repository of reference signal data is generated. The repository comprises a plurality of reference signals derived by an MR signal simulation for a plurality of different transverse relaxation rates, a plurality of different fat fractions, and the MR pulse sequence type. A first reference signal is identified in the plurality of reference signals. The first reference signal provides a best match to the test signal based on one or more matching criteria. The repository is searched to determine a first transverse relaxation rate and a first fat fraction associated with the first reference signal. Then, the amount of fat and iron in the anatomical tissue is estimated based on the first transverse relaxation rate and the first fat fraction.
    Type: Application
    Filed: October 24, 2013
    Publication date: April 24, 2014
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventor: Brian Dale
  • Patent number: 8706457
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: April 22, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Patent number: 8682626
    Abstract: A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: March 25, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Razvan Ioan Ionasec, Ingmar Voigt, Viorel Mihalef, Sasa Grbic, Dime Vitanovski, Yang Wang, Yefeng Zheng, Bogdan Georgescu, Dorin Comaniciu, Puneet Sharma, Tommaso Mansi
  • Patent number: 8634618
    Abstract: A method for surgical planning is disclosed. A set of related two-dimensional (2D) anatomical images or 3D images is displayed. A plurality of anatomical landmarks are identified on the set of anatomical images. A three-dimensional (3D) representation of a parent prosthesis is scaled to match a scale of the 2D anatomical images based at least in part on a relationship between the anatomical landmarks. A 2D representation of the scaled 3D parent prosthesis is displayed on at least one of the 2D anatomical images. A system for surgical planning is also disclosed. The system has a prosthesis knowledge-based information system, a patient anatomical-based information system, a user interface, and a controller. The controller has an anatomical landmark identifier. The controller also has a prosthesis-to-anatomical-feature relator. The controller is configured to display a set of related two-dimensional (2D) anatomical images from the patient anatomical-based information system on the user interface.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: January 21, 2014
    Assignee: FUJIFILM Medical Systems USA, Inc.
    Inventors: James Andrew Zug, Micah Aaron Forstein, Emil Michael Saraga, Jr.
  • Patent number: 8600125
    Abstract: In the present methods, the automatic detection of polyps is converted into a 2D pattern recognition problem using conformal mapping and direct volume rendering. The colon surface is first segmented and extracted from the CT data set of the abdomen, which is then mapped to a 2D plane using conformal mapping. Ray casting is used to determine sub-surface density values and the flattened image is rendered using a volume rendering technique with a translucent electronic biopsy transfer function. Polyp candidates are detected by a clustering method which identifies regions of elevated sub-surface density. The potential for false positives is reduced by analyzing the volumetric shape and texture features of the polyp candidate regions.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: December 3, 2013
    Assignee: The Research Foundation of State University of New York
    Inventors: Arie E. Kaufman, Wei Hong, Xianfeng Gu, Feng Qiu
  • Patent number: 8576087
    Abstract: A radiation imaging system includes a radiation imaging cassette and a console device. A communication mode between the cassette and the console device is switchable between a wired mode and a wireless mode. Due to shortage of a battery of the cassette, the communication mode is switched to the wired mode to start charging the battery and send image data from the cassette to the console device through a cable. The console device has first and second judging sections. The first judging section judges whether or not a charge level of the battery exceeds a predetermined threshold value. The second judging section judges whether or not radiography is in progress. If it is judged that the charge level of the battery exceeds the predetermined threshold value and the radiography is not in progress, a window that indicates permission for switching to the wireless mode is displayed on a monitor.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: November 5, 2013
    Assignee: Fujifilm Corporation
    Inventors: Takeshi Kamiya, Yusuke Kitagawa
  • Publication number: 20130281829
    Abstract: Systems and methods for Magnetic Resonance Angiography (MRI) are provided. One method includes obtaining Magnetic Resonance (MR) velocity data and determining a distance map for one or more vessels to define a distance path. The method also includes calculating, using the MR velocity data, at a plurality of time intervals and for a plurality of pixels (i) a distance traveled during a current time interval as a current distance traveled, wherein a total distance traveled is incremented by the current distance traveled and (ii) a bolus signal using a bolus signal profile, the distance path and total distance traveled, wherein a current time interval is incremented by a defined time step.
    Type: Application
    Filed: April 19, 2012
    Publication date: October 24, 2013
    Applicant: General Electric Company
    Inventors: Ek Tsoon Tan, Thomas Kwok-Fah Foo, Vincent B. Ho
  • Patent number: 8548778
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: October 1, 2013
    Assignee: HeartFlow, Inc.
    Inventors: Gregory Richard Hart, John Henry Stevens
  • Patent number: 8543187
    Abstract: A first plurality of MR signals from a patient's tissue at respectively corresponding successive first time increments extending over a first time interval including a substantial majority of a subject's cardiac cycle is acquired and analyzed to define a second time interval, shorter than the first time interval, during the cardiac cycle whereat there is a relatively steep rise in signal magnitudes as a function of time (e.g., corresponding with systole and diastole events of the cardiac cycle). A second plurality of MR signals is then acquired from tissue of the patient at respectively corresponding successive second time increments during the second time interval, the second time increments being substantially shorter than said first time increments. Image data representing at least one contrast-free image of flowing fluid vessels is generated based on the second plurality of MR signals.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: September 24, 2013
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Mitsue Miyazaki
  • Patent number: 8480404
    Abstract: The present invention teaches a medical procedure training system based on a PC platform that provides multimodal education within a virtual environment. The system integrates digital video, three-dimensional modeling, and force-feedback devices for the purpose of training medical professionals medical procedures.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: July 9, 2013
    Inventor: Eric A. Savitsky
  • Patent number: 8433113
    Abstract: An exemplary embodiment of the present invention includes a method of detecting a left ventricle blood pool. The method includes: localizing a region of interest (ROI) in a three-dimensional temporal (3D+T) image based on motion information of each slice of the 3D image over time, thresholding the ROI to determine pixels of the ROI that correspond to blood, extracting connected components from the determined pixels, clustering the extracted connected components into groups based on criteria that are indicative of a blood pool of a left ventricle, and selecting one of the groups as the left ventricle blood pool.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: April 30, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventor: Marie-Pierre Jolly
  • Patent number: 8433392
    Abstract: The present invention provides an MRI system for imaging of a subject over extended field-of-view (FOV) that employs both accelerated data acquisition, which is employed while the subject is stationary, and traditional data acquisition, which is employed while the subject is moved through the MRI system. This approach provides improved spatial resolution and time efficiency compared to traditional extended FOV imaging techniques.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: April 30, 2013
    Assignee: MAYO Foundation for Medical Education and Research
    Inventor: Stephen J. Riederer
  • Patent number: 8335552
    Abstract: When delivering a therapy to a patient, such as a drug to a brain of a patient, an optimized delivery point can be selected. The optimized point can be based on physics, physiology, and pharmacology. The optimized point can be used for planning a surgical navigation procedure.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: December 18, 2012
    Assignee: Medtronic, Inc.
    Inventor: David Stiles
  • Patent number: 8297983
    Abstract: An ultrasound training system having a data capture module, a digital asset management module, a validation module, didactic content, a media asset production module, an integration layer, an internet-based portal, a software client, and a peripheral probe. The combination of the disclosed elements creates a system that enables the creation and delivery of high-quality ultrasound education and training in a low-cost, widely deployable, and scalable manner, with a facilitated method for processing orders and financial transactions between customers and content providers.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: October 30, 2012
    Assignee: The Regents of the University of California
    Inventors: Eric Savitsky, Dan Katz, Gabriele Nataneli, Kresimir Petrinec
  • Patent number: 8295907
    Abstract: A computational model which integrates a complex circulatory model and a finite element to determine the dynamics of a left ventricle continuously over consecutive cardiac cycles. The model includes determining a LV pressure (plv) using a circulatory model, using a finite element model plv as input and determining a LV volume (vlv), computing a LV elastance according to: elv=plv/vlv, driving the circulatory model with the elv; and returning to determining a LV pressure and starting the next iteration, wherein the steps continue at a sufficient time resolution for a desired number of entire cardiac cycles. The dynamic Young's modulus functions are assigned to individual finite elements, resulting in a time-varying left ventricular elastance that drives the circulatory model.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: October 23, 2012
    Assignee: Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
    Inventors: Ying Sun, Frederick J. Vetter, Rumei Dong, Salvatore A. Chiaramida
  • Patent number: 8275446
    Abstract: A computer system and a computer-implemented method are provided for interactively displaying a three-dimensional rendering of a structure having a lumen and for indicating regions of abnormal wall structure. A three-dimensional volume of data is formed from a series of two-dimensional images representing at least one physical property associated with the three-dimensional structure. An isosurface of a selected region of interest is created by a computer from the volume of data based on a selected value or values of a physical property representing the selected region of interest. A wireframe model of the isosurface is generated by the computer wherein the wireframe model includes a plurality of vertices. The vertices are then grouped into populations of contiguous vertices having a characteristic indicating abnormal wall structure by the computer. The wireframe model is then rendered by the computer in an interactive three-dimensional display to indicate the populations of abnormal wall structure.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: September 25, 2012
    Assignee: Wake Forest University Health Sciences
    Inventors: David J. Vining, Gordon W. Hunt, David K. Ahn, David R. Stelts, Yaorong Ge, Paul F. Hemler, Tiffany W. Salido
  • Patent number: 8275442
    Abstract: Methods and system for treatment planning for non- and minimally-invasive alteration of body adipose tissue for reduction and contouring of body fat are described herein. Treatment plans can be generated by capturing current body part data (e.g., positioning, contour/shape, thickness of adipose tissue, etc.), determining desired outcome of treatment (e.g., percent reduction of adipose tissue thickness, degree of contour change, etc.), and determining treatment parameters to achieve desired results. Algorithms can be used to determine best-fit treatment parameters to use in treatment sessions. In some embodiments, the system can provide a predictive end-result image for communication to patient and/or for determining alteration of desired outcome. In various embodiments, real-time monitoring of feedback data can be used to determine treatment plan efficacy.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: September 25, 2012
    Assignee: Zeltiq Aesthetics, Inc.
    Inventor: John W. Allison
  • Patent number: 8260397
    Abstract: In a method to determine a kidney function parameter of kidneys of an examination person with the aid of magnetic resonance tomography, at least one magnetic resonance measurement is implemented for an examination region of the examination person that comprises a urinary bladder of the examination person, to acquire magnetic resonance data from the examination region that include at least image data. The concentration of a urophanic substance in the urinary bladder of the examination person is automatically determined based on the acquired magnetic resonance data. A volume of the urinary bladder is automatically determined based on the acquired image data. A kidney function parameter of the kidneys of the examination person is automatically determined on the basis of the determined concentration of the urophanic substance in the urinary bladder and of the specific volume of the urinary bladder.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: September 4, 2012
    Assignee: Siemens Aktiengesellschaft
    Inventors: Jan Ruff, Stefan Roell, Sebastian Schmidt
  • Patent number: 8255036
    Abstract: The present invention relates to a method of characterizing lung function in a subject in need of such characterization. The method comprises performing an imaging technique, on a voxel defined within a lung space of interest. Image data is generated over a time period during which the subject inhales gases with at least two different partial pressures of a paramagnetic gas. A compartmental model algorithm is applied to the image data generated for the voxel to provide information on ventilation, diffusion and perfusion of a lung. The paramagnetic gas is preferably Oxygen. The imaging technique is preferably Oxygen Enhanced Magnetic Resonance Imaging (OE-MRI).
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: August 28, 2012
    Assignee: The University of Manchester
    Inventors: Deirdre McGrath, Geoffrey Parker
  • Patent number: 8249687
    Abstract: A method of operating on volumetric imaging data representing organ anatomy includes determining whether a polyp location within a specified range from a viewing point is visible, or hidden by an anatomical feature, and marking the polyp as visible or hidden with a viewable indicator.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: August 21, 2012
    Assignee: Vital Images, Inc.
    Inventors: Samuel W. Peterson, Thomas J. Gleeson, Marek Brejl, Marguerite Kirkby
  • Patent number: 8214014
    Abstract: A method of determining the size and/or placement of screws or other instruments in pedicles during surgery in a selected spinal area, comprising generating a dimensionally true three-dimensional image of the bony spine in the selected spinal area; hollowing out the vertebra in the three-dimensional image with cortical wall thicknesses selected by a surgeon performing the surgery; determining the narrowest cross section (isthmus) within each pedicle; generating a straight line starting at the center of the isthmus and extending inwardly to a point centered within the anterior cortex so that it is positioned concentrically within the pedicle without touching the walls thereof, the line terminating inside the vertebral body a predetermined distance from the anterior inner cortical wall and extending outwardly in the opposite direction to penetrate the posterior pedicle cortex; expanding the line concentrically and radially to a cross sectional size that is less than that of the isthmus, the line being expanded
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: July 3, 2012
    Assignee: Leucadia 6, LLC
    Inventor: Hector O. Pacheco
  • Publication number: 20120116210
    Abstract: A method, including constructing a simulated surface of a body cavity, and pressing a distal end of a probe against a wall of the body cavity. While pressing the distal end against the wall, position measurements are accepted from the probe indicating a position of the probe within the body cavity, and force measurements are accepted from the probe indicating a force between the distal end and the wall. A distortion in the simulated surface is created at the position indicated by the position measurements, so as to form a distorted surface, upon detecting that the force measurements exceed a predefined amount. The distorted surface is then displayed.
    Type: Application
    Filed: November 4, 2010
    Publication date: May 10, 2012
    Inventor: Eliahu Zino
  • Publication number: 20120116211
    Abstract: method for identifying and activating specific axonal pathways for achieving therapeutic benefits during a neural stimulation, such as deep brain stimulation. Clinical data, diffusion tensor tractography, and computer models of patient-specific neurostimulation may be used to identify particular axonal pathways activated by deep brain stimulation and to determine their correlations with specific clinical outcomes.
    Type: Application
    Filed: October 19, 2011
    Publication date: May 10, 2012
    Applicant: The Cleveland Clinic Foundation
    Inventors: Cameron C. McIntyre, J. Luis Lujan, Ashutosh Chaturvedi
  • Patent number: 8175350
    Abstract: An image guidance system is provided for improving tissue culture extraction where the tissue is extracted under the guidance of first and second knowledge-based systems. The first knowledge-based system provides initial suggested regions of interest for tissue biopsy in an internal organ. These regions of interest are then confirmed as being of interest of being benign by the second knowledge-based system. Information from two different sources may provide a more accurate, intelligent and robust method that helps in selecting biopsy sites accurately, such that suspicious regions are not overlooked and the benign regions are not unnecessarily operated upon. This not only helps in better diagnosis and treatment, but also helps reduce pain to the patient, in addition to reducing wastage of resources and invaluable time.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: May 8, 2012
    Assignee: Eigen, Inc.
    Inventors: Jasjit S. Suri, Liyang Wei, Dinesh Kumar
  • Patent number: 8170644
    Abstract: Mapping of myelin water content in white matter may provide important information for early diagnosis of multiple sclerosis and the detection of white matter abnormality in other diseases. It is disclosed here that free induction decay (FID) of each voxel at multiple slice locations is acquired in the brain using an echo-planar spectroscopic imaging (EPSI) pulse sequence. The multi-slice EPSI acquisition is designed to have a short first echo time (˜2 ms) and echo-spacing (˜1 ms) in order to acquire multiple sampling points during the fast decay of the myelin water signal. Multi-compartment analysis is then applied to the FID in each pixel using a 3-pool model of white matter to obtain quantitative maps of the myelin water fraction. Using this technique, the MR data for whole brain mapping of the myelin water can be acquired in less than 10 minutes, making this technique feasible for routine clinical applications.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: May 1, 2012
    Assignee: The Regents of the University of Colorado
    Inventor: Yiping Du
  • Patent number: 8160326
    Abstract: A method of surgical modeling is disclosed. A set of related two-dimensional (2D) anatomical images is displayed. A plurality of anatomical landmarks is identified on the set of related 2D anatomical images. A three-dimensional (3D) representation of at least one prosthesis is scaled to match a scale of the 2D anatomical images based at least in part on a relationship between the anatomical landmarks. 3D information from the at least one prosthesis along with information based on at least one of the plurality of anatomical landmarks is utilized to create procedure-based information. A system for surgical modeling is also disclosed. The system has a prosthesis knowledge-based information system, a patient anatomical-based information system, a user interface, and a controller. The controller has an anatomical landmark identifier, a prosthesis-to-anatomical-feature relator, and a procedure modeler.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: April 17, 2012
    Assignees: Fujifilm Medical Systems USA, Inc., FUJIFILM Corporation
    Inventors: James Andrew Zug, Micah Aaron Forstein, Emil Michael Saraga, Jr.
  • Patent number: 8160325
    Abstract: A method for surgical planning is disclosed. A set of related two-dimensional (2D) anatomical images or 3D images is displayed. A plurality of anatomical landmarks are identified on the set of anatomical images. A three-dimensional (3D) representation of a parent prosthesis is scaled to match a scale of the 2D anatomical images based at least in part on a relationship between the anatomical landmarks. A 2D representation of the scaled 3D parent prosthesis is displayed on at least one of the 2D anatomical images. A system for surgical planning is also disclosed. The system has a prosthesis knowledge-based information system, a patient anatomical-based information system, a user interface, and a controller. The controller has an anatomical landmark identifier. The controller also has a prosthesis-to-anatomical-feature relator. The controller is configured to display a set of related two-dimensional (2D) anatomical images from the patient anatomical-based information system on the user interface.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: April 17, 2012
    Assignees: Fujifilm Medical Systems USA, Inc., FUJIFILM Corporation
    Inventors: James Andrew Zug, Micah Aaron Forstein, Emil Michael Saraga, Jr.
  • Patent number: 8140365
    Abstract: In a workflow management method and apparatus, one or more computers are programmed to receive an original sequence, such as a scan sequence which controls a diagnostic scanner to perform an imaging procedure. An available time span within which to perform the original sequence is also received. The available time span is compared with a duration of the original scan sequence. If the original scan sequence duration is longer than the available time span, one or more alterable subsequences of the original sequence are shortened to create an adjusted scan sequence that fits into the available time span.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: March 20, 2012
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Rudolf Theodoor Springorum, Frederik Visser, Jouke Smink, Leonardus Carolus Petrus Josephus Mollevanger
  • Patent number: 8115486
    Abstract: An MRI apparatus comprises a waveform controlling means for calculating a radio frequency pulse and applying the pulse to an irradiating means, and the waveform controlling means reads out a radio frequency pulse waveform vector from a first memory means which memorizes multiple radio frequency pulse waveform vectors, calculates a simulated irradiation pattern, and calculates a radio frequency pulse waveform which gives the minimum value of weighted sum of squares of differences of absolute values and squares of differences of phases for an ideal irradiation pattern and the simulated irradiation pattern. An RF pulse waveform showing superior ideal irradiation pattern reproducibility and providing reduced power of the RF waveform is formed, and safety of MRI subject is improved by performing imaging using such an RF pulse.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: February 14, 2012
    Assignee: Hitachi, Ltd.
    Inventors: Hideta Habara, Yoshitaka Bito
  • Patent number: 8112144
    Abstract: Since cerebral atrophy does not occur only in a specific cross-section and reaches the brain in its entirety or arises prominently in a specific lobe (for example temporal lobe), for the assessment of cerebral atrophy, not only atrophy assessment for the frontal lobe but also an assessment also including atrophy of the temporal lobe, the parietal lobe and the occipital lobe is more desirable. The intracranial volume, the volume of the grey matter and the volume of the white matter are respectively extracted, computed and converted into numbers by image processing from a plurality of MRI slice images and the like. Ratios of these values from the conversions into numbers are taken to calculate the ratio of the grey matter and the ratio of the white matter with respect to the entire brain. Through comparison of a multitude of measurement data obtained by this automated computation, and a case, an objective cerebral atrophy assessment is carried out.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: February 7, 2012
    Assignees: National University Corporation Shizuoka University, National University Corporation Hamamatsu University School of Medicine
    Inventors: Seiji Yamamoto, Baigalmaa Tsagaan, Keiichi Abe
  • Patent number: 8082127
    Abstract: A method for determining the spatial distribution of magnetic resonance signals from an imaging area, wherein nuclear spins are excited in a spatially encoded fashion through multi-dimensional RF pulses, is characterized in that in a definition step, a resolution grid with resolution grid cells is predetermined, and in accordance with a predetermined phase encoding scheme, an excitation pattern is defined for each phase encoding step, in which the amplitudes within the imaging area are set in accordance with a predetermined distribution identically for each phase encoding step. In a preparatory step, the amplitude and phase behavior of the RF pulses to be irradiated is calculated in accordance with a predetermined k-space trajectory for each defined complex excitation pattern.
    Type: Grant
    Filed: September 13, 2008
    Date of Patent: December 20, 2011
    Assignee: Bruker BioSpin MRI GmbH
    Inventor: Wolfgang Ruhm
  • Patent number: 8064983
    Abstract: One or more techniques are provided for determining the overall motion of an organ of interest relative to a viewer or imager. Motion data is acquired for the organ of interest and/or for one or more proximate organs using sensor-based and/or image data-based techniques. The sensor-based techniques may include electrical and non-electrical techniques. The image data-based techniques may include both pre-acquisition and acquisition image data. The motion data for the organ of interest and proximate organs may be used to determine one or more quiescent periods corresponding to intervals of minimal motion for the organ of interest and the proximate organs. The one or more quiescent periods may be used to determine one or more gating points that may be used prospectively, i.e., during image acquisition. In addition, the one or more quiescent periods may be used to determine one or more motion compensation factors that may be used during processing and reconstruction of the acquired image data.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: November 22, 2011
    Assignee: General Electric Company
    Inventors: Prathyusha K. Salla, Gopal B. Avinash, Cherik Bulkes
  • Patent number: 8027430
    Abstract: Various embodiments of the invention include systems and methods for adapting a movement model based on an image captured during radiation treatment of a patient. The movement model may, for example, be used in radiotherapy to treat lung cancer. The movement model is typically based on a series of images of a patient captured over a period of time. The movement model and/or one or images included therein may be used to generate a reference image of the patient. The reference image is compared with an image of the patient optionally captured during treatment. The result of this comparison is used to adapt the movement model to conditions during the treatment.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: September 27, 2011
    Assignee: Varian Medical Systems International AG
    Inventors: Janne Ilmari Nord, Jarkko Yrjänä Peltola
  • Patent number: 7966055
    Abstract: In a method for representation of the heart in a magnetic resonance system at least one MR overview image of the heart is acquired. An image plane with a predetermined position relative to the magnetic resonance system is selected for this overview image. The acquired MR overview image is displayed and a number of marking points are established in the displayed overview image. Further image planes for representation of the heart are calculated using some of the established marking points. Further MR images are acquired in the calculated image planes.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: June 21, 2011
    Assignee: Siemens Aktiengesellschaft
    Inventors: Jens Guehring, Michaela Schmidt, Peter Speier