Magnetic Resonance Imaging Or Spectroscopy Patents (Class 600/410)
  • Patent number: 11966816
    Abstract: Aspects of generating error-resistant quantum control pulses from geometrical curves are described. In some embodiments, a closed space curve is parameterized for a target gate operation of a quantum computing device. The closed space curve corresponds to an evolution operator of a time-dependent Schrödinger equation associated with the target gate operation. A control field definition is identified for the target gate operation based at least in part on a geometrical analysis of the evolution operator of the time-dependent Schrödinger equation. The target gate operation is implemented for the quantum computing device based on the control field definition.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: April 23, 2024
    Assignee: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventors: Edwin Barnes, Junkai Zeng
  • Patent number: 11937908
    Abstract: A method of performing magnetic resonance imaging of a body includes a) immerging the body in a static and substantially uniform magnetic field; b) exciting nuclear spins inside the body using at least one radio-frequency pulse; c) applying to the body a time-varying magnetic field gradient defining at least one trajectory (ST) in k-space and simultaneously acquiring samples of a magnetic resonance signal so as to perform a pseudo-random sampling (KS) of the k-space; and d) applying a sparsity-promoting nonlinear reconstruction algorithm for reconstructing a magnetic resonance image of the body; wherein, at least in a low-spatial frequency region of the k-space, the distance between any two adjacent points belonging to a same trajectory is lower than 1/FOV, FOV being the size of a field of view of the reconstructed image. A magnetic resonance imaging apparatus for carrying out such a method is also provided.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: March 26, 2024
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES PARIS, FRANCE, UNIVERSITÉ PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Nicolas Chauffert, Philippe Ciuciu, Jonas Kahn, Carole Lazarus, Alexandre Vignaud, Pierre Weiss
  • Patent number: 11933871
    Abstract: According to one embodiment, MRI apparatus includes processing circuitry and an imaging device. The processing circuitry is configured to acquire at least one of body size information relating to a size of an object and breath-hold information relating to a breath-holdable time of the object. The processing circuitry is further configured to determine an imaging condition to be performed on the object based on the at least one of the body size information and the breath-hold information. The imaging device performs imaging of the object in accordance with the determined imaging condition.
    Type: Grant
    Filed: August 12, 2022
    Date of Patent: March 19, 2024
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Shinya Ozawa, Takeshi Ishimoto
  • Patent number: 11935158
    Abstract: A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: March 19, 2024
    Assignee: Cedars-Sinai Medical Center
    Inventors: Anthony Christodoulou, Zhaoyang Fan, Debiao Li, Pei Han
  • Patent number: 11931149
    Abstract: Described herein is a method of using functional MRI (fMRI) for determining brain activation patterns for a group of subjects in response to different odor-elicited feelings (i.e., conscious emotions). A method for preparing a perfume by using the method of the present invention and a consumer product including said perfume are also described herein.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: March 19, 2024
    Assignee: FIRMENICH SA
    Inventors: Aline Pichon, Patrik Vuilleumier, Sylvain Delplanque, David Sander, Isabelle Cayeux, Christelle Porcherot, Maria Inés Velazco, Christian Margot
  • Patent number: 11921182
    Abstract: Systems and methods provide accelerated MR thermometry utilizing prior knowledge about the images to be reconstructed from incomplete k-space data, thereby facilitating accurate reconstruction. In various embodiments, missing data is computationally estimated using a machine learning algorithm such as a neural network, and an image is generated based on iteratively updated estimated missing information.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: March 5, 2024
    Assignee: INSIGHTEC LTD.
    Inventors: Yuval Zur, Boaz Shapira, Yoav Levy
  • Patent number: 11903691
    Abstract: A method to automatically align magnetic resonance (MR) scans for diagnostic scan planning includes acquiring a three-dimensional (3D) localizer image of an anatomical object. One or more initial landmarks are identified in the 3D localizer image using a landmarking engine. One or more main axes associated with the anatomical object are identified based on the one or more initial landmarks. The 3D localizer image is registered to a canonical space based on the main axes associated to yield a registered 3D localizer image. The landmarking engine is applied to the registered 3D localizer image to yield one or more updated landmarks. A plurality of reference points for performing a MR scan are computed based on the one or more updated landmarks.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: February 20, 2024
    Assignee: Siemens Healthineers AG
    Inventors: Fitsum Aklilu Reda, Yiqiang Zhan, Martin Harder
  • Patent number: 11893662
    Abstract: An imaging system includes a sensor configured to receive imaging data, where the imaging data comprises k-space data from a magnetic resonance imaging (MRI) scan of a patient. The imaging system also includes a processor operatively coupled to the sensor and configured to identify a degree of interaction between measured points of the k-space data located at a radius from a center of k-space. The processor is also configured to determine, based at least in part on the degree of interaction between the measured points, density weights for a density compensation filter. The processor is also configured to apply the density compensation filter to the k-space data to generate filtered k-space data. The processor is further configured to generate an MRI image of the patient based at least in part on the filtered k-space data.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: February 6, 2024
    Assignee: Northwestern University
    Inventors: Kyungpyo Hong, Daniel Kim
  • Patent number: 11883202
    Abstract: One example of a system includes a local user system to interact with an implantable medical device and a local input device communicatively coupled to the local user system to generate local events. To operate the local user system, the local user system is to receive local events from the local input device and remote events from a remote user system communicatively coupled to the local user system via a medical device remote access system. The local user system is to process a local event and ignore a remote event in response to receiving a local event and a remote event simultaneously.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 30, 2024
    Assignee: Medtronic, Inc.
    Inventors: Corey E. Ney, Kent D. Magaard
  • Patent number: 11867783
    Abstract: A system and method are provided for analysing a functional magnetic resonance imaging (MRI) scan representing a time-sequence, comprising t time points, of images comprising v voxels, where each scan can be represented by a data matrix X?t×v. The method comprises modelling the scan data X as the convolution of neural activation time courses N?+t×v and a haemodynamic filter ?, and performing an inverse operation to estimate N from X and ?. The method further compasses decomposing the neural activation time courses N into multiple brain network components by representing N as the product of a first matrix H defining, for each component, a spatial map of the voxels belonging to that component, and a second matrix W defining, for each component, the time sequence of activation of that component during the scan. In other implementations, the matrix decomposition may be performed before the deconvolution.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: January 9, 2024
    Assignee: King's College London
    Inventors: Michael Hutel, Sebastien Ourselin
  • Patent number: 11857288
    Abstract: A method of cardiac strain analysis uses displacement encoded magnetic resonance image (MRI) data of a heart of the subject and includes generating a phase image for each frame of the displacement encoded MRI data. Phase images include potentially phase-wrapped measured phase values corresponding to pixels of the frame. A convolutional neural network CNN computes a wrapping label map for the phase image, and the wrapping label map includes a respective number of phase wrap cycles present at each pixel in the phase image. Computing an unwrapped phase image includes adding a respective phase correction to each of the potentially-wrapped measured phase values of the phase image, and the phase correction is based on the number of phase wrap cycles present at each pixel. Computing myocardial strain follows by using the unwrapped phase image for strain analysis of the subject.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: January 2, 2024
    Assignee: University of Virginia Patent Foundation
    Inventors: Sona Ghadimi, Changyu Sun, Xue Feng, Craig H. Meyer, Frederick H. Epstein
  • Patent number: 11857275
    Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: January 2, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Adi Maron-Katz
  • Patent number: 11848098
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining anomalous brain data. One of the methods includes obtaining brain data characterizing brain activity of a patient; for each of a plurality of pairs of parcellations comprising a first parcellation and a second parcellation, processing the brain data to generate a correlation between the brain activity of the first and second parcellations; obtaining second connectivity data that characterizes, for each of the plurality of pairs of parcellations, a normal range of correlations between the brain activity of the first and second parcellations; identifying one or more of the plurality of pairs of parcellations for which the correlation between brain activity of the first and second parcellations is outside of the corresponding normal range of correlations; and providing data characterizing the one or more identified pairs of parcellations for display to a user on a graphical interface.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: December 19, 2023
    Assignee: Omniscient Neurotechnology Pty Limited
    Inventors: Michael Edward Sughrue, Stephane Philippe Doyen, Peter James Nicholas
  • Patent number: 11844599
    Abstract: An embodiment of the present invention provides a scanning control system for a magnetic resonance imaging system, comprising: a first 3D camera, configured to capture a three-dimensional image of a scan subject located on a scanning table of the magnetic resonance imaging system; a processing device, configured to identify body position information of the scan subject based on the three-dimensional image; and a control device, configured to set scanning parameters related to a body position based on the body position information.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: December 19, 2023
    Assignee: GE Precision Healthcare LLC
    Inventors: Qingyu Dai, Yanting Huo, Jiabin Yao, Saban Kurucay, Jonathan C West, Yuwen Li
  • Patent number: 11841411
    Abstract: In a method and apparatus for acquiring and reconstructing a four-dimensional dynamic magnetic resonance (MR) image data record, MR data are continuously acquired by radial scanning of an examination region along radial k-space lines, and a dynamic region of the examination region, in which said dynamic procedure is relevant, is determined, as well as a non-dynamic region, which is not relevant to the dynamic procedure. Static image data are reconstructed from all of the acquired MR data, and image data therein originating from the non-dynamic region are marked and are then not used for reconstructing a dynamic image data record for the dynamic region.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: December 12, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: Ralf Kartaeusch, Simon Bauer
  • Patent number: 11842491
    Abstract: A method of generating a quantitative characterization of injury presence and status of spinal cord tissue using an adaptive CNN system for use in diagnostic assessment, surgical planning, and therapeutic strategy comprises preprocessing for artifact correction of diffusion based, spinal cord MRI data, training an adaptive CNN system with healthy and abnormal (injured/pathologic) spinal cord images obtained by imaging a population of healthy, typically developed spinal cord subjects and subjects with spinal cord injury, evaluating a novel, diffusion-based MRI image for injury biomarkers using the adaptive CNN system, generating a three-dimensional predictive axonal damage map for quantitative characterization and visualization of the novel, diffusion-based MRI image, and transmitting the sets of healthy and injured spinal cord images back to a central database for continued improvement of the adaptive CNN system training. A system for defining a predictive spinal axonal damage map is also described.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 12, 2023
    Assignee: Thomas Jefferson University
    Inventors: Christopher J. Conklin, Feroze B. Mohamed, Devon M. Middleton, Mahdi Alizadeh
  • Patent number: 11842427
    Abstract: A method and system for reducing or removing motion artefacts in magnetic resonance (MR) images, the method including the steps of: receiving a motion corrupted MR image; determining a corrected intensity value for each pixel in the motion corrupted MR image by using a neural network; and generating a motion corrected MR image based on the determined corrected intensity values for the pixels in the motion corrupted MR image.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: December 12, 2023
    Inventors: Kamlesh Pawar, Zhaolin Chen, Nadim Joni Shah, Gary Francis Egan
  • Patent number: 11835604
    Abstract: A method for ascertaining at least one of a position or an orientation of an MR local coil unit for arrangement inside a main magnetic field includes providing a first 3D relative position of a reference sensor system in relation to the main magnetic field; receiving an acceleration vector from at least one acceleration sensor; retrieving a distance vector describing a fixed relative position as a function of the received acceleration vector; calculating a second 3D relative position of the at least one acceleration sensor in relation to the main magnetic field based on the first 3D relative position and the retrieved distance vector; and ascertaining the at least one of the position or the orientation of the MR local coil unit using the first 3D relative position and the second 3D relative position.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: December 5, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: Johann Sukkau, Volker Matschl, Steffen Schroeter
  • Patent number: 11837354
    Abstract: Described herein is medical imaging technology for concurrent and simultaneous synthesis of a medical CA-free-AI-enhanced image and medical diagnostic image analysis comprising: receiving a medical image acquired by a medical scanner in absence of contrast agent enhancement; providing the medical image to a computer-implemented machine learning model; concurrently performing a medical CA-free-AI-enhanced image synthesis task and a medical diagnostic image analysis task with the machine learning model; reciprocally communicating between the image synthesis task and the image analysis task for mutually dependent training of both tasks. Methods and systems and non-transitory computer readable media are described for execution of concurrent and simultaneous synthesis of a medical CA-free-AI-enhanced image and medical diagnostic image analysis.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: December 5, 2023
    Assignee: London Health Sciences Centre Research Inc.
    Inventor: Shuo Li
  • Patent number: 11815579
    Abstract: According to one embodiment, a magnetic resonance imaging apparatus includes sequence control circuitry and processing circuitry. The sequence control circuitry performs under-sampled data acquisition whose sample points are located at an equal interval in k-space and acquires k-space frames. The processing circuitry generates a plurality of k-space frames related to a plurality of time resolutions based on the k-space frames. In each of the plurality of k-space frames, the sample points are located at an equal interval, and the interval differs for each of the plurality of k-space frames. The processing circuitry generates a time-series image based on the plurality of k-space frames.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: November 14, 2023
    Assignee: Canon Medical Systems Corporation
    Inventor: Hidenori Takeshima
  • Patent number: 11806196
    Abstract: A head stabilization device or HFD includes a plurality of integrated markers. The HFD may be in the form of a skull clamp, vacuum bag, combinations thereof, or other supporting structure. The integrated markers include MRI markers detectable by an MRI scanner and fiducial markers detectable by a registration tool of a navigation system. The markers provide a reference point relative to an operation site in a patient for use in a navigation guided procedure and aid in registering or calibrating the location of the patient with captured images used in the navigation guided procedure.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: November 7, 2023
    Assignees: pro med instruments GmbH, Brainlab AG
    Inventors: Matthias E. Schuele, Sascha Kubis, Roman Maier
  • Patent number: 11808832
    Abstract: A computer-implemented method for generating an artifact corrected reconstructed contrast image from magnetic resonance imaging (MRI) data is provided. The method includes inputting into a trained deep neural network both a synthesized contrast image derived from multi-delay multi-echo (MDME) scan data or the MDME scan data acquired during a first scan of an object of interest utilizing a MDME sequence and a composite image, wherein the composite image is derived from both the MDME scan data and contrast scan data acquired during a second scan of the object of interest utilizing a contrast MRI sequence. The method also includes utilizing the trained deep neural network to generate the artifact corrected reconstructed contrast image based on both the synthesized contrast image or the MDME scan data and the composite image. The method further includes outputting from the trained deep neural network the artifact corrected reconstructed contrast image.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: November 7, 2023
    Assignee: GE Precision Healthcare LLC
    Inventors: Sudhanya Chatterjee, Dattesh Dayanand Shanbhag
  • Patent number: 11796611
    Abstract: A method for medical imaging may include determining a posture of an object and obtaining a first parameter of a pulse sequence to be applied to the object. The method may also include determining, based on the posture and the first parameter, a SAR distribution model and estimating, based on the SAR distribution model and a second parameter of the pulse sequence to be applied, a SAR distribution associated with the object under the pulse sequence to be applied. The second parameter is associated with calibration of the pulse sequence to be applied. The method may further include determining whether the estimated SAR distribution meets a condition and causing, in response to a result of the determination that the estimated SAR distribution associated with the object meets the condition, a scanner to perform an MR scan on the object according to the pulse sequence.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: October 24, 2023
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Zhenhua Shen, Qiang He
  • Patent number: 11779295
    Abstract: The present invention discloses a method and a system of vertebral compression fracture detection. The method of vertebral compression fracture detection includes: recombining a plurality of anatomical images captured in at least a spine segment of a target individual into a 3D image; using a multi-planar reconstruction method to reformat the 3D image to obtain at least one sagittal reformatted image; using a classification model to determine whether the sagittal reformatted image covers the middle section of the vertebral column or not; using a vertebral detection method to detect each vertebral body in the sagittal reformatted image covering the middle section of the vertebral column; using a keypoint localization method to localize a plurality of keypoints of each vertebral body which was detected in the sagittal reformatted image; evaluating the compression fracture grade of each vertebral body in the sagittal reformatted image.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: October 10, 2023
    Assignees: QUANTA COMPUTER INC., TAIPEI MEDICAL UNIVERSITY
    Inventors: Wing P. Chan, Ai-Ling Hsu, Kuan-Chieh Huang, Yi-Ting Peng, Ching-Chung Kao
  • Patent number: 11771364
    Abstract: A bone density estimating method, comprising: acquiring, by an MR scanning device, a magnetic resonance, MR, sequence of a body portion, wherein the MR sequence comprises quantitative information of the body portion; generating, by a processing circuit, an MR image of the body portion based on the MR sequence, wherein each voxel of the MR image represents a volume of the body portion; identifying, by the processing circuit, a part of the MR image representing a bone portion of the body portion; for a voxel of the identified part of the MR image, estimating a bone density of a volume of the bone portion represented by the voxel, based on a quantitative value of the voxel. The quantitative information of the body portion comprises a proton density.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: October 3, 2023
    Assignee: SYNTHETICMR AB (PUBL)
    Inventor: Marcel Warntjes
  • Patent number: 11763948
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient using a centrality ranking of the brain of the patient. One of the methods includes obtaining brain data of a patient, wherein the brain data comprises, for each of a plurality of pairs of parcellations formed from a set of parcellations where each pair comprises a first parcellation and a second parcellation, data characterizing a number of tracts connecting the first parcellation and the second parcellation; determining a network graph from the brain data; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; determining a centrality ranking of the plurality of nodes of the network graph according to the respective measures of centrality; generating a mental health prediction for the patient using the determined centrality ranking.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: September 19, 2023
    Assignee: Omniscient Neurotechnology Pty Limited
    Inventors: Michael Edward Sughrue, Stephane Philippe Doyen, Peter James Nicholas, Hugh Monro Taylor
  • Patent number: 11756198
    Abstract: In some aspects, the described systems and methods provide for a method for training a statistical model to predict tissue characteristics for a pathology image. The method includes accessing annotated pathology images. Each of the images includes an annotation describing a tissue characteristic category for a portion of the image. A set of training patches and a corresponding set of annotations are defined using an annotated pathology image. Each of the training patches in the set includes values obtained from a respective subset of pixels in the annotated pathology image and is associated with a corresponding patch annotation determined based on an annotation associated with the respective subset of pixels. The statistical model is trained based on the set of training patches and the corresponding set of patch annotations. The trained statistical model is stored on at least one storage device.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: September 12, 2023
    Assignee: PathAI, Inc.
    Inventors: Andrew H. Beck, Aditya Khosla
  • Patent number: 11740310
    Abstract: A positioning method for a magnetic resonance imaging system comprises: acquiring a scattering parameter curve of a body coil during a process in which an examination table carrying a subject under examination enters a scanning bore of the magnetic resonance imaging system; acquiring the position of a part to be examined of the subject under examination on the basis of the scattering parameter curve; and moving the examination table on the basis of the position of the part to be examined such that the part to be examined is located at the center of the scanning bore.
    Type: Grant
    Filed: March 23, 2022
    Date of Patent: August 29, 2023
    Assignee: GE Precision Healthcare LLC
    Inventors: Yaan Ge, Kun Wang, Qingyu Dai, Liya Ma
  • Patent number: 11723732
    Abstract: A surgical system for manipulating an anatomy includes a surgical tool, a robotic manipulator configured to support and move the surgical tool, and one or more controllers that activate a first virtual boundary delineating a first portion of the anatomy that is allowed to be removed by the surgical tool from a second portion of the anatomy that is protected from removal by the surgical tool. The one or more controllers control the robotic manipulator for enabling the surgical tool to perform bulk cutting of the first portion in relation to the first virtual boundary. The one or more controllers control the robotic manipulator for enabling the surgical tool to perform fine cutting of the second portion of the anatomy.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: August 15, 2023
    Assignee: MAKO Surgical Corp.
    Inventors: David Gene Bowling, John Michael Stuart, Jerry A. Culp, Donald W. Malackowski, José Luis Moctezuma de la Barrera, Patrick Roessler, Joel N. Beer
  • Patent number: 11712192
    Abstract: The present disclosure relates to a method for providing biomarker for early detection of Alzheimer's Disease (AD), and particularly to a method that is able to enhance the accuracy of predicting AD from Mild Cognitive Impairment (MCI) patients using the Hippocampus magnetic resonance imaging (MRI) scans and Mini-Mental State Examination (MMSE) data. The providing MRI images containing the anatomical structure of Hippocampus biomarker and MMSE data as a training data set; training a processor using the training data set, and the training comprising acts of receiving MRI images and MMSE data as a testing data set from a target; and classifying the test data by the trained processor to include aggregating predictions.
    Type: Grant
    Filed: December 22, 2019
    Date of Patent: August 1, 2023
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Gwo Giun Lee, Te-Han Kung, Tzu-Cheng Chao, Yu-Min Kuo, Meng-Ru Tsai
  • Patent number: 11707201
    Abstract: Systems and methods are provided for enhanced heart medical imaging operations, particularly as by incorporating use of artificial intelligence (AI) based fetal heart functional analysis and/or real-time and automatic ejection fraction (EF) measurement and analysis.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: July 25, 2023
    Assignee: GE PRECISION HEALTHCARE LLC
    Inventors: Dani Pinkovich, Sarit Shwartz, Noa Alkobi, Robert Anderson, Antonio Fabian Fermoso, Walter Duda, Jr., Christian Fritz Perrey
  • Patent number: 11690558
    Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: July 4, 2023
    Assignee: The Trustees of Dartmouth College
    Inventors: David W. Roberts, Keith D. Paulsen, Alexander Hartov, Songbai Ji, Xiaoyao Fan
  • Patent number: 11684435
    Abstract: A system and method for ensuring safe and tolerable insertion of a needle into a subject's body according to a preplanned or continuously monitored sequence of insertion steps. The system comprises a gripping device for gripping the needle in order to perform robotic insertion steps, yet for releasing the grip between such insertion steps, until the next insertion step is initiated. Thereby, the robot has full control of the needle during insertion steps, but does not constrain the needle between insertions, such that movement of the subject can cause neither damage nor discomfort. The gripping and insertion steps may be coordinated to keep in synchronization with the subject's breathing cycles, such that the insertion steps may be performed in the same segment of each cycle of motion of the subject's chest. The gripper can either fully disconnect from the needle, or can partially disconnect but constrain motion within limits.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: June 27, 2023
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Daniel Glozman, Gonen Daskal, Moshe Shoham, Michael Arad, Yoav Pinsky
  • Patent number: 11672466
    Abstract: A system and method is provided for modeling brain dynamics in normal and diseased states.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: June 13, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Jin Hyung Lee
  • Patent number: 11672468
    Abstract: Methods and systems for diagnosing a condition of a central nervous system are provided. A method includes providing a DBSI-MRI data set obtained from the central nervous system of the subject, and transforming the DBSI-MRI data set to obtain at least one DBSI biomarker value. The method further includes comparing each DBSI biomarker value to at least one corresponding threshold value from a diagnostic database to obtain a relation between each DBSI biomarker value and the at least one corresponding threshold value, and diagnosing the condition according to at least one diagnostic rule, wherein each diagnostic rule defines a candidate condition in terms of the relations between the at least one DBSI biomarker value and the at least one corresponding threshold value.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: June 13, 2023
    Assignee: Washington University
    Inventors: Yong Wang, Qing Wang, Tammie Benzinger
  • Patent number: 11666219
    Abstract: Methods and apparatus for providing a functional mapping of a brain lesion in a patient's brain. The method comprises determining using a computer processor, based on human connectome data stored on at least one computer datastore in communication with the computer processor, at least one functional network associated with a location of a brain lesion identified in an image of a patient's brain. The at least one functional network includes a plurality of brain areas functionally connected to the location of the brain lesion and a plurality of correlation measures. Each of the correlation measures indicates a strength of functional connection between the location of the brain lesion and a respective brain area of the plurality of brain areas in the at least one functional network. The method further comprises determining, based at least one functional network, a likelihood that the brain lesion is causing one or more patient symptoms.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: June 6, 2023
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventor: Michael D. Fox
  • Patent number: 11657547
    Abstract: An apparatus includes: an acquisition circuit; and a processing circuit configured to: acquire volume data; set a model representing a tissue included in the volume data; set a first view for visualizing the volume data and a position of a target in the model; acquire first operation information for deforming the model; calculate change in the position and an orientation of the target due to deformation of the model, based on the first operation information; calculate, using the calculated change in the position and the orientation of the target, a second view such that the position and the orientation of the target after the change with respect to the first view and the position and the orientation of the target before the change with respect to the second view become equal to each other; and visualize the volume data based on the second view.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: May 23, 2023
    Assignee: ZIOSOFT, INC.
    Inventor: Tsuyoshi Nagata
  • Patent number: 11644520
    Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. In one aspect, in accordance with one embodiment, a method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: May 9, 2023
    Assignee: University of Virginia Patent Foundation
    Inventors: Yekaterina K. Gilbo, Helen L. Sporkin, Samuel W. Fielden, John P. Mugler, III, Grady W. Miller, IV, Steven P. Allen, Craig H. Meyer
  • Patent number: 11612361
    Abstract: According to an embodiment, an information display system includes a displacement measurement unit, a display unit, and a controller. The displacement measurement unit measures displacement of a measurement part. The display unit displays a time axis of signal detection. The controller controls the displacement measurement unit and the display unit. When a signal that is output from the displacement measurement unit meets a given condition, the controller determines that displacement of the measurement part is detected and displays detection information representing that the displacement is detected in any one of a time position and a time area on the display unit in which the displacement is detected.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: March 28, 2023
    Assignee: RICOH COMPANY, LTD.
    Inventors: Hideaki Yamagata, Noriyuki Tomita, Aritaka Hagiwara, Shinya Mukasa, Yutaka Yagiura, Daisuke Sakai
  • Patent number: 11589928
    Abstract: The inventive subject matter is directed to an artificial intelligence intra-operative surgical guidance system and method of use. The artificial intelligence intra-operative surgical guidance system is made of a computer executing one or more automated artificial intelligence models trained on data layer datasets collections to calculate surgical decision risks, and provide intra-operative surgical guidance; and a display configured to provide visual guidance to a user.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: February 28, 2023
    Assignee: Orthogrid Systems Holdings, LLC
    Inventors: Richard Boddington, Edouard Saget, Joshua Cates, Hind Oulhaj, Erik Noble Kubiak
  • Patent number: 11583217
    Abstract: A method of analyzing neurophysiological data recorded from a subject is disclosed. The method comprises identifying activity-related features in the data, and parceling the data according to the activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain. The method further comprises comparing at least some of the defined capsules to at least one reference capsule, and estimating a brain function of the subject based on the comparison.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: February 21, 2023
    Assignee: Firefly Neuroscience Ltd.
    Inventors: Amir B. Geva, Yaki Stern, Amit Reches
  • Patent number: 11580626
    Abstract: A computer apparatus and methods generate multi-parametric color composite images from multi-echo chemical shift encoded (CSE) MRI. Some embodiments use inherently co-registered images (i.e., image maps) that are combined into a single intuitive composite color image. The color (e.g., brightness, hue, and/or saturation) reflects in part the water and fat content, and other properties, particularly T2* relaxation (related to magnetic susceptibility) of the tissue.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: February 14, 2023
    Inventor: Kenneth L. Weiss
  • Patent number: 11579227
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and processing circuitry. The sequence controlling circuitry is configured to execute (i) a first pulse sequence in which a spatially selective Inversion recovery (IR) pulse and a spatially non-selective IR pulse are applied, and subsequently an acquisition is performed and (ii) a second pulse sequence in which the spatially non-selective IR pulse is applied without applying the spatially selective IR pulse, and subsequently an acquisition is performed, while varying the first TI period, with respect to a plurality of first TI periods. The processing circuitry is configured to calculate a second TI period to be used in a third pulse sequence and a fourth pulse sequence, based on data obtained from the first pulse sequence and the second pulse sequence.
    Type: Grant
    Filed: July 13, 2021
    Date of Patent: February 14, 2023
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Mitsue Miyazaki, Yoshimori Kassai
  • Patent number: 11573283
    Abstract: Provided is a method for generating MRI data including applying, by an MRI computing device, an RF excitation pulse, and completing, by the MRI computing device, a K-space by acquiring a plurality of phase encoding line groups, in a state in which any other RF excitation pulse is not applied after applying the RF excitation pulse, in which each of the plurality of phase encoding line groups includes a plurality of phase encoding lines, and an absolute value of an average phase encoding size of a phase encoding line group acquired earlier is not greater than an absolute value of an average phase encoding size of a phase encoding line group acquired later, among the plurality of phase encoding line groups.
    Type: Grant
    Filed: July 20, 2021
    Date of Patent: February 7, 2023
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sung-Hong Park, Hyun-Soo Lee
  • Patent number: 11564619
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: January 31, 2023
    Assignees: ACLARION, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey C. Lotz, James Clayton Peacock, III, David S. Bradford, Stefan Dudli, Sergey G. Magnitsky
  • Patent number: 11551371
    Abstract: A method for analyzing an image to assess a degree of asymmetry in an object having a presumed mirror symmetry includes: retrieving an image of the object; obtaining a mirrored image by flipping along an axis that has an a-priori unknown spatial relation to the presumed plane of symmetry; obtaining a mapping between the retrieved image and the mirrored image; determining a measure of asymmetry in the object by considering element pairs of a first element of the retrieved image and a second element of the mirrored image according to the mapping. Obtaining the mapping comprises performing a rigid registration followed by a non-rigid registration of the retrieved image to the mirrored image. The measure of asymmetry is determined by calculating the Jacobian of the non-rigid deformation in each element of the image. The invention also pertains to a computer program product and an image processing system.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: January 10, 2023
    Assignee: ICOMETRIX NV
    Inventors: Dirk Smeets, Diana Sima
  • Patent number: 11547317
    Abstract: A system comprises determination of an inversion-recovery or saturation-recovery imaging pulse sequence associated with first values of echo spacing, flip angle, effective TR, trigger pulses, artifact post-suppression, and number of image data lines per acquisition, execution of a scout pulse sequence comprising a plurality of single-shot image data acquisitions to acquire respective sets of image data lines, where each of the plurality of single-shot image data acquisitions is executed using a different respective inversion time and where each of the plurality of single-shot image data acquisitions is associated with second values of echo spacing, flip angle, and number of image data lines per acquisition which are substantially similar to corresponding ones of the first values, generation of a plurality of images based on the respective sets of image data lines, determination of one of the plurality of images, the determined one of the plurality of images generated based on a set of image data lines acquire
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: January 10, 2023
    Assignee: Siemens Healthcare GmbH
    Inventor: Wolfgang G. Rehwald
  • Patent number: 11544842
    Abstract: A medical image diagnostic apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain image data which is generated by scanning a brain of a subject; select a target region from the image data; extract a connected region of which a brain function is associated with a brain function of the target region, as an additional region; and output scan target region including the target region and the additional region.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: January 3, 2023
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Qiqi Xu, Fanjie Meng, Hitoshi Yamagata
  • Patent number: 11540794
    Abstract: The inventive subject matter is directed to a computing platform configured to execute one or more automated artificial intelligence models, wherein the one or more automated artificial intelligence models includes a neural network model, wherein the one or more automated artificial intelligence models are trained on a plurality of radiographic images from a data layer to detect a plurality of anatomical structures or a plurality of hardware, wherein at least one anatomical structure is a pelvic teardrop and a symphysis pubis joint; detecting at a plurality of anatomical structures in a radiographic image of a subject, wherein the plurality of anatomical structures are detected by the computing platform by the step of classifying the radiographic image with reference to a subject good side radiographic image; and constructing a graphical representation of data, wherein the graphical representation is a subject specific functional pelvis grid; the subject specific functional pelvis grid generated based upon th
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: January 3, 2023
    Assignee: Orthogrid Systesm Holdings, LLC
    Inventors: Richard Boddington, Edouard Saget, Joshua Cates, Hind Oulhaj, Erik Noble Kubiak
  • Patent number: 11536791
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a processing circuit. The processing circuit acquires a plurality of echo signals not to be encoded corresponding to a plurality of respective shots about acquisition of a plurality of echo signals having been encoded by magnetic resonance imaging for a subject, compares the echo signals not to be encoded with each other about the shots, and identifies a shot to be removed about generation of a magnetic resonance image about the subject out of the shots based on a comparison result of the echo signals not to be encoded.
    Type: Grant
    Filed: November 17, 2021
    Date of Patent: December 27, 2022
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Masahito Nambu, Samir Dev Sharma, Anuj Sharma