Of Fluid Flow Patents (Class 600/419)
  • Patent number: 11931954
    Abstract: A method of producing a test body for diffusion tensor imaging, which comprises a plurality of channels in a structuring material, the channels preferably having a maximum cross-section of 625 ?m2, wherein a virtual model of the test body is created and the virtual model is fed to a structuring device which produces the test body by means of a 3D printing-based, in particular lithography-based, structuring process, the structuring process being designed as a multiphoton lithography process, in particular as a multiphoton absorption process, in which the structuring material containing a photosensitizer or photoinitiator is irradiated in a location-selective manner, wherein the radiation is successively focused on focal points lying within the structuring material, resulting in that in each case a volume element of the material located in the focal point is subjected to a change in state by means of a photochemical reaction as a result of multiphoton absorption.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: March 19, 2024
    Assignee: TECHNISCHE UNIVERSITAT WIEN
    Inventors: Aleksandr Ovsianikov, Peter Gruber, Christian Windischberger, Zoltan Nagy
  • Patent number: 11672436
    Abstract: Heart rates and beat lengths of a subject can be extracted from videos of the subject by measuring subtle head motion caused by the Newtonian reaction to the influx of blood at each beat. Embodiments track features on the video images of the subject's head and perform principal component analysis (PCA) to decompose the feature location-time series into a set of component motions. The method or system then selects a component that best corresponds to heartbeats based on its temporal frequency spectrum. Finally, the motion projected to this component is analyzed and peaks of the location-time series are identified, which correspond to heartbeats. Pulse rate measurements or heart rate measurements of the subject are output.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: June 13, 2023
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Guha Balakrishnan, John V. Guttag, Frederic Durand
  • Patent number: 11669961
    Abstract: The image processing device includes a voxel extractor, a learner, and a predictor. The voxel extractor extracts a target voxel and neighboring voxels adjacent to the target voxel from a 3D image. The learner generates vectors corresponding to the target voxel and the neighboring voxels, respectively, generates vector weights corresponding to each of the vectors, based on the vectors and a parameter group, and adjusts the parameter group, based on an analysis result of the target voxel generated by applying the vector weights to the vectors. The predictor generates vectors corresponding to the target voxel and the neighboring voxels, respectively, generates correlation weights among the vectors by applying a parameter group to the vectors, generates vector weights corresponding to each of the vectors by applying the correlation weights to the vectors, and generates an analysis result of the target voxel by applying the vector weights to the vectors.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: June 6, 2023
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Ho-Youl Jung, Jae Hun Choi
  • Patent number: 11598833
    Abstract: A method is provided for the saturation-prepared recording of MR image data. The method includes establishment of at least two measurement slices in an examination volume of an examination object, wherein the examination volume has adjacent slices which each adjoin at least one of the at least two measurement slices; output of a saturation module including at least one saturation pulse for saturating a magnetization of the adjacent slices; output of an excitation pulse for exciting a magnetization of at least one of the at least two measurement slices; readout of an MR signal of the examination volume; reconstruction of the MR image data from the at least two measurement slices based on the MR signal; and provision of the MR image data. The disclosure further relates to a magnetic resonance system and a computer program product.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: March 7, 2023
    Assignee: Siemens Healthcare GmbH
    Inventor: Hans-Peter Fautz
  • Patent number: 11561273
    Abstract: A medical image processing apparatus including processing circuitry configured to obtain MR dynamic images acquired by MR imaging on a subject, in which a contrast agent has been injected, in accordance with an examination-time imaging condition including magnetic field information, contrast agent information, and/or tissue information, set a standard imaging condition, and calculate a first index value indicating a temporal change of an MR signal value caused by the contrast agent, the index value being standardized by conversion from the examination-time imaging condition to the standard imaging condition based on the MR dynamic images, the examination-time imaging condition, and the standard imaging condition.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: January 24, 2023
    Assignee: Canon Medical Systems Corporation
    Inventor: Shigeharu Ohyu
  • Patent number: 11532244
    Abstract: Ultrasound (US) simulation systems and methods are provided, which utilize computer tomography (CT) data to generate US simulation images, offline or online. Systems and methods repeatedly derive and display consecutive US simulation images that correspond to consecutively-derived corresponding US slices (according to the changing locations and orientations of a dummy US transducer mimicking the US transducer with respect to a physical patient model)—that define geometrically US simulation regions. The US simulation images are at least partly derived from CT data using a CT to US conversion model. Acoustic parameters (e.g., tissue density, acoustic attenuation and impedance) are calculated and integrated per pixel, along beams in the US slice, to form the US image. Additional modelling may be used to calculate reflection and scattering and their effects on the image pixels, and enhancements such as animation and flow data may be added.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: December 20, 2022
    Assignee: Simbionix Ltd.
    Inventors: Yaron Peleg, Victor Levin
  • Patent number: 11450430
    Abstract: A system has a measuring device providing a readout of a physiological condition, an imaging apparatus with an Internet connection, an image recognition module executing on the imaging apparatus, the image recognition module adapted to compare images to a library of options, and to process the readout by optical character recognition (OCR), and an internet-connected server coupled to a data repository, the Internet-connected server executing coded instructions on a processor.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: September 20, 2022
    Assignee: INVENT.LY LLC
    Inventor: Stephen J Brown
  • Patent number: 11417242
    Abstract: A technique simulator for training in a technique using a catheter includes: a flow path configured to contain a liquid that imitates blood; a liquid flow generation member configured to generate flow of the liquid; and a catheter insertion port configured to allow the catheter to be interposed into the flow path. The flow path includes: a bifurcated portion that is located downstream of the catheter insertion port and is to be bifurcated into at least two flow paths, and a plurality of bifurcated flow paths provided downstream of the bifurcated portion. The plurality of bifurcated flow paths includes a first bifurcated flow path and a second bifurcated flow path. The technique simulator further comprises a pressure difference generation member configured to cause a pressure difference to be generated between a downstream side of the first bifurcated flow path and a downstream side of the second bifurcated flow path.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: August 16, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Makoto Takahashi, Junichi Fukamizu, Daiki Nozawa, Kouji Ozaki
  • Patent number: 11417240
    Abstract: A training device and an associated method for simulating a static, dynamic, statically contrasted, and/or dynamically contrasted fluid motion within a three-dimensional (3D) vascular bed.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: August 16, 2022
    Inventor: Bernhard Meyer
  • Patent number: 11413097
    Abstract: Methods and apparatus are provided for mapping and displaying a three dimensional (3D) surgical pathway. Entry and target voxels are selected along with a semi-target voxel therebetween. Where voxels representing bone are between the entry and target voxels, the semi-target voxel is selected such that voxels representing bone are not within a shortest line between it and the entry voxel. A series of voxels through the semi-target voxel define the pathway. For each voxel V in the series between the semi-target voxel and one of the endpoint voxels, the immediately succeeding voxel of voxel V is selected from among the group of neighbor voxels of voxel V by comparing selection weights of each voxel determined a selected basis including relative distances with respect to the endpoint voxel and the semi-target voxel. The pathway voxels are selectively highlighted in a displayed view to provide a visualization of the 3D surgical pathway.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: August 16, 2022
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: Yair Palti, Remi Bettan, Vadim Gliner, Uri Avni
  • Patent number: 11410317
    Abstract: A method for calculating a 3D representation of a vascular malformation of a vascular structure is provided. The method comprises: providing 2D X-ray image data of a vascular structure containing a contrast agent and having a vascular malformation, providing 3D image data of the vascular structure and transforming the 3D image data into transformed 2D image data, overlaying the 2D X-ray image data and the transformed 2D image data; calculating a correspondence between the 2D X-ray image data and the transformed 2D image data to determine a co-registration between the 2D X-ray image data and the 3D image data, determining in the co-registered 2D X-ray image data the vascular malformation, and calculating the 3D representation of the vascular malformation based on the determined vascular malformation of the co-registered 2D X-ray image data.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: August 9, 2022
    Assignee: Brainlab AG
    Inventors: Kristin Paul, Robert Lucht
  • Patent number: 11399730
    Abstract: Devices and methods are provided for analyzing images from a magnetic resonance (MR) system. The device includes at least one hardware processor coupled with a storage system accessible to the at least one hardware processor. The device further includes a display in communication with the at least one hardware processor. The device receives a plurality of non-contrast MR images in a region of interest (ROI). The device obtains blood flow signals from the plurality of non-contrast MR images. The device identifies an abnormal segment by analyzing the blood flow signals. The device displays the non-contrast MR images by a highlighted segment in at least one of the non-contrast MR images to indicate the abnormal segment on the display.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 2, 2022
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Mitsue Miyazaki, Tsutomu Hoshino, Xiangzhi Zhou
  • Patent number: 11398027
    Abstract: A method and a system create an age-specific quantitative atlas for a biological object. The method includes obtaining a quantitative map of the biological object for each subject of a healthy subject population, generating an age-specific initial map for the biological object using a weighted mean, and spatially registering each of the quantitative maps on the age-specific initial map. The generating and registering steps are repeated iteratively until reaching a first predefined alignment threshold between all spatially registered quantitative maps. The new age-specific initial map obtained is stored at the end of the iterative process of the repeating step as the age-specific quantitative atlas for a biological object characterized by the specific age.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: July 26, 2022
    Assignee: Siemens Healthcare GmbH
    Inventors: Tom Hilbert, Tobias Kober
  • Patent number: 11369279
    Abstract: Systems and methods are provided to incorporate an off-resonance correction into the pulse labeling train of PCASL/VEPCASL. In one or more aspects, the systems and methods are based on a method for generating an encoding scheme for any number and arrangement of blood vessels. The off-resonance correction can be incorporated into the generation of optimized encodings to acquire arterial spin labeling (ASL) data, such as PCASL and VEPCASL data.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: June 28, 2022
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Eleanor Berry, Thomas Okell, Peter Jezzard
  • Patent number: 11300641
    Abstract: A system and method for performing a measuring sequence by a magnetic resonance device for examining a patient is provided. The performance of the measuring sequence includes a processing of segments. If at least one determined patient load value exceeds a predetermined limit value, the processing of the measuring sequence for the time frame of exceeding the patient load value is interrupted. The determination of the at least one patient load value includes a detection of a movement of a patient into a changed pose, an adjustment of at least one following segment to the changed pose of the patient, and a determination of at least one patient load value for the adjusted at least one following segment.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: April 12, 2022
    Assignee: Siemens Healthcare GmbH
    Inventor: Dominik Paul
  • Patent number: 11253551
    Abstract: Heart failure with preserved ejection fraction (HFpEF) is a disease condition characterized by heart failure (HF) signs and symptoms, but with normal or near normal left ventricular ejection fraction (LVEF) and is not responsive to standard therapy for treatment of HF. Described herein are compositions and methods related to use of cardiosphere derived cells (CDCs) and their exosomes to improve left ventricular structure, function and overall outcome. Administration of CDCs led to improved LV relaxation, lower LV end-diastolic pressure, decreased lung congestion and enhanced survival. Lower risk of arrhythmias in HFpEF was also observed following CDC administration. Improvement of diastolic dysfunction following administration of CDC-derived exosomes was observed, along with decreased mortality. In view of these salutary effects, CDCs and CDC-derived exosomes are beneficial in the treatment of HFpEF.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: February 22, 2022
    Assignee: Cedars-Sinai Medical Center
    Inventors: Eduardo Marban, Romain Gallet
  • Patent number: 11241163
    Abstract: Aspects of the subject disclosure may include, for example, obtaining first magnetic resonance imaging (MRI) data of a subject, wherein the first MRI data is obtained during a first scan of a subject, wherein the first scan has a first diffusion sampling time, and wherein the first diffusion sampling time is selected in order to facilitate use of the first MRI data to determine a first Intravoxel Incoherent Motion (IVIM) effective diffusion coefficient in a Stationary Random Flow (SRF) regime; obtaining second MRI data of the subject, wherein the second MRI data is obtained during a second scan of the subject, wherein the second scan has a second diffusion sampling time, wherein the second diffusion sampling time is longer than the first diffusion sampling time, and wherein the second diffusion sampling time is selected in order to facilitate use of the second MRI data to determine a second IVIM effective diffusion coefficient in a pseudodiffusion regime; determining a blood velocity value based upon the firs
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 8, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Bradley P. Sutton, Alexander M. Cerjanic, Luisa Ciobanu, Denis LeBihan, Jing-Rebecca Li, Gabrielle Fournet
  • Patent number: 11094138
    Abstract: A medical imaging system configured to link acquired images to markers or tags on an anatomical illustration, based, at least in part on spatial and anatomical data associated with the acquired image. The medical imaging system may be further configured to generate a diagnostic report including the anatomical illustration containing the markers. The diagnostic report may allow a user to select a marker to view information associated with an acquired image and/or the acquired image. Multiple images may be associated with a marker, and/or multiple markers may be associated with an image. A set of 2D and/or 3D anatomical illustrations may be generated which contains markers from multiple diagnostic reports and updated automatically for an individual patient's anatomical model by the application to reflect measurements and/quantitative findings related to organ, tissue, and vessel size, location, deformation, and/or obstruction.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: August 17, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Earl M. Canfield, Wendy Mei Yee
  • Patent number: 11085979
    Abstract: Systems and methods for generating an image of a subject using a magnetic resonance imaging (MRI) device may be provided. The method may include obtaining a radial sampling scheme including a plurality of radial lines that each pass through a center of k-space. The method may include selecting the plurality of radial lines of the radial sampling scheme. Each of the plurality of radial lines may be selected in a random and unrepeatable manner. The method may include acquiring k-space data along the selected radial lines. The method may include reconstructing at least one image of the subject based on the acquired k-space data.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: August 10, 2021
    Assignee: UIH AMERICA, INC.
    Inventors: Jingyuan Lyu, Yu Ding, Xiaomao Gong, Qi Liu, Jian Xu, Weiguo Zhang
  • Patent number: 11049246
    Abstract: The present invention provides a rapid calculation method and system for a plaque stability index based on a medical image sequence. The system includes an image acquisition module, an image receiving module, an image processing module, a finite element calculation module and a result visualization module. The image acquisition module and the image receiving module are configured to acquire, receive and transmit a dynamic two-dimensional vascular image sequence; the image processing module is configured to acquire a space-transformational displacement field function by taking a local feature or a global image as a registration based on dynamic information of real-time deformation of an artery under a two-dimensional image; and the finite element calculation module is configured to acquire a time-dependent vascular lumen diameter sequence and a contour deformation parameter as well as a mechanical index by calculation performed by virtue of the above-mentioned displacement field function.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: June 29, 2021
    Assignee: SHAGHAI JIAO TONG UNIVERSITY
    Inventors: Shengxian Tu, Xinlei Wu, Su Zhang, Jiayue Huang
  • Patent number: 11004201
    Abstract: A movement of an area whose shape changes for each respiration or for each heartbeat is displayed. A diagnosis support program that analyzes images of a human body and displays analysis results, the program causing a computer to execute: processing of acquiring a plurality of frame images from a database that stores the images (S1); processing of specifying a respiratory cycle based on pixels in a specific area in each of the frame images (S2); processing of detecting a lung field based on the specified respiratory cycle (S3); processing of dividing the detected lung field into a plurality of block areas (S4) and calculating a change in image in a block area in each of the frame images (S5); processing of performing a Fourier analysis of a change in image in each block area in each of the frame images (S6); and processing of displaying each image after the Fourier analysis on a display as a pseudo color image (S7).
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: May 11, 2021
    Assignee: PARAMEVIA PTE. LTD.
    Inventors: Takehiko Abe, Norifumi Yoshida
  • Patent number: 10859658
    Abstract: A system and method for controlling a magnetic resonance imaging (MRI) system to create magnetic resonance (MR) cine angiograms of a subject. The method includes controlling the MRI system to acquire MR data from the subject by performing at least one cine acquisition pulse sequence having a plurality of acquisition RF pulse modules applied at constant intervals throughout a cardiac cycle, and at least one labeling pulse sequence including a first and a second ?/2 module and a labeling RF pulse module for labeling a region of inflowing arterial flow through a vessel of interest. The method further includes reconstructing the MR data to form a series of cine frames that form a cine angiogram, subtracting at least one cine frame from other cine frames reconstructed from the MR data, and displaying the MR cine angiogram of the vessel of interest.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: December 8, 2020
    Assignee: NORTHSHORE UNIVERSITY HEALTHSYSTEM
    Inventors: Robert R. Edelman, Ioannis Koktzoglou
  • Patent number: 10768258
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes processing circuitry. The processing circuitry performs at least one of data collection for collecting first data of an imaging region of a subject at a plurality of time intervals after a tag pulse is applied to fluid flowing into the imaging region, and data collection for collecting second data of the imaging region by differing at least one of applying or not-applying the tag pulse and a position of the applying. The processing circuitry performs phase correction for at least one of the first data and the second data by using data in which the longitudinal magnetization of the fluid is a positive value, to generate an image for each time phase.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: September 8, 2020
    Assignee: Canon Medical Systems Corporation
    Inventors: Tokunori Kimura, Naotaka Sakashita
  • Patent number: 10684341
    Abstract: A method of magnetic resonance imaging (100, 200) includes acquiring (300) tagged magnetic resonance data (144) by controlling the magnetic resonance imaging system with tagging pulse sequence commands (140). The tagging pulse sequence commands include a tagging inversion pulse portion (404) for spin labeling a tagging location (122, 122?) within a subject (118). The tagging pulse sequence commands comprise a phase-contrast readout portion (406) which phase-contrast encodes in at least one direction. The control pulse sequence commands include a control inversion pulse portion (500) and the phase-contrast readout portion. A tagged magnitude image (148) is reconstructed (304) using the tagged magnetic resonance data. A control magnitude image (150) is reconstructed (306) using the control magnetic resonance data. An arterial image (152) is reconstructed (308) by subtracting the control magnitude image and the tagged magnitude image.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: June 16, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Michael Gunter Helle, Thomas Lindner
  • Patent number: 10684340
    Abstract: A magnetic resonance imaging system and method are provided for improved determination of noise bias effects in calculating fitted parameters for quantitative MRI procedures. The system and method includes selecting a range for the SNR and fitted parameter values, and for each of a plurality of base pairs of these values and for a plurality of b values, adding a random noise term to the real and imaginary components of a plurality of corresponding signal terms, fitting magnitudes of the resulting “noisy” signals to determine a “noisy” fitted parameter value, and compare the “noisy” and base fitted parameter values to determine a noise-based error for each pair of base values. The noise-based errors can be used to generate an error map, modify imaging parameters to reduce such errors, or correct fitted parameters directly.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: June 16, 2020
    Assignees: Siemens Healthcare GmbH, Duke University
    Inventors: Xiaodong Zhong, Marcel Dominik Nickel, Stephan Kannengiesser, Brian Dale, Berthold Kiefer, Mustafa R. Bashir
  • Patent number: 10670678
    Abstract: An object (10) is placed in an examination volume of a MR device (1). To enable fast MR imaging, a stack-of-stars acquisition scheme is employed with a reduced level of streaking artifacts. The acquisition scheme includes subjecting the object (10) to an imaging sequence of at least one RF pulse and switched magnetic field gradients and acquiring MR signals according to the stack-of-stars scheme. The MR signals are acquired as radial k-space profiles (S1-S12) from a number of parallel slices (21-27) arranged at different positions along a slice direction. The radial density of the k-space profiles (S1-S12) varies as a function of the slice position with the radial density being higher at more central k-space positions and lower at more peripheral k-space positions. The k-space profiles are acquired at a higher temporal density from slices at the more central positions than from slices at the more peripheral k-space positions. An MR image is reconstructed from the MR signals.
    Type: Grant
    Filed: June 12, 2016
    Date of Patent: June 2, 2020
    Assignee: Koninklijke Philips N.V.
    Inventor: Gabriele Marianne Beck
  • Patent number: 10624952
    Abstract: The invention relates to systems and methods for the diagnosis, amelioration, and treatment of ischemic tissues in patients caused by and/or resulting from diminished microvascular blood flow. Patients suffering from ischemic tissue conditions can be categorized into specific subsets that are deemed to have a potential to respond to therapy. In particular, the invention includes various therapies involving stimulation of angiogenesis, vasculogenesis, arteriogenesis and/or neovascularization so as to increase perfusion of various tissues.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: April 21, 2020
    Assignees: CardioVascular BioTherapeutics, Inc.
    Inventors: Vance Gardner, Hon Yu, Kenneth A. Thomas, Thomas J. Stegmann, John W. Jacobs, Tugan Muftuler, Shadfar Bahri
  • Patent number: 10591568
    Abstract: A magnetic resonance imaging system and method are provided for improved phase-sensitive magnetic resonance imaging of tissues affected by cardiovascular pulsatile motion. A magnetically-prepared image dataset and corresponding reference image dataset (for phase sensitivity) are obtained within the duration of a single cardiac cycle. The paired datasets can be single-shot or segmented datasets and a navigator sequence can optionally be provided with each paired dataset. The system and method take advantage of the shape symmetry of the cardiac cycle to acquire the paired dataset in a shorter time interval, thereby reducing misregistration artifacts. The magnetic preparation can include inversion recovery pulses, FIDDLE sequences, other magnetic preparation sequences, or combinations thereof. The reference dataset can be acquired at a lower resolution than the corresponding magnetically-prepared dataset without compromising image quality.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: March 17, 2020
    Assignees: Siemens Healthcare GmbH, Duke University
    Inventors: Wolfgang G. Rehwald, David C. Wendell, Elizabeth R. Jenista, Enn-Ling Chen, Raymond J. Kim
  • Patent number: 10310040
    Abstract: In a magnetic resonance apparatus and method for acquiring magnetic resonance data, a magnetic resonance data acquisition scanner executes a turbo spin echo (TSE) data acquisition sequence with simultaneous multi-slice (SMS) imaging wherein nuclear spins in two different slices of an examination subject are simultaneously excited so as to produce respective echo trains. The magnetic resonance data acquisition scanner is operated with the SMS imaging configured so that magnetic resonance signals from the respective slices have a different contrast, with the SMS being configured to allow evolution of magnetization of the nuclear spins for the second contrast while magnetic resonance signals with the first contrast are being detected. The respective magnetic resonance signals from the two different slices are detected and entered into an electronic memory organized as k-space, as k-space data.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: June 4, 2019
    Assignee: Siemens Healthcare GmbH
    Inventors: Himanshu Bhat, Pedro Miguel Itriago Leon, Mario Zeller
  • Patent number: 10274558
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and image generating circuitry. The sequence controlling circuitry acquires magnetic resonance signals in an imaging region. The image generating circuitry generates an image. The sequence controlling circuitry sets timings of RF pulses such that a first time and a second time are different. Here, the first time is a time since an irradiation of a first RF pulse without selection of region until a start of acquisition. The second time is a time since an irradiation of a second RF pulse with selection of the labeling region until the start of acquisition. The second time is also a time for a liquid present in the labeling region to reach a desired position in the imaging region. The first time is also a time for longitudinal magnetization components of a background tissue to become substantially zero.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 30, 2019
    Assignees: KYOTO UNIVERSITY, TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Hiroyoshi Isoda, Koji Fujimoto, Hiroshi Kusahara
  • Patent number: 10188355
    Abstract: Embodiments relate to a method and system to improve fat suppression and reduce motion and off-resonance artifacts in magnetic resonance imaging (MRI) by using a background-suppressed, reduced field-of-view (FOV) radial imaging. The reduction of such artifacts provides improved diagnostic image quality, higher throughput of MRI scans for the imaging center, and increased patient comfort. By using a small FOV radial acquisition that only encompasses the structures of interest, structures that cause motion artifacts, such as the anterior abdominal wall, bowel loops, or blood vessels with pulsatile flow, are excluded from the image. According to an embodiment, combining a small FOV radial acquisition with one or more background-suppression techniques minimizes the impact of artifacts caused by anatomy outside of the FOV.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: January 29, 2019
    Assignees: Siemens Healthcare GmbH, Northshore University Healthsystem
    Inventors: Shivraman Giri, Robert R. Edelman, Ioannis Koktzoglou
  • Patent number: 10139460
    Abstract: A delta-relaxation magnetic resonance imaging (DREMR) system is provided. The system includes a main field magnet and field shifting coils. A main magnetic field with a strength B0 can be generated using the main filed magnet and the strength B0 of the main magnetic field can be varied through the use of the field-shifting coils. The DREMR system can be used to perform signal acquisition based on a pulse sequence for acquiring at least one of T2*-weighted signals imaging; MR spectroscopy signals; saturation imaging signals and MR signals for fingerprinting. The MR signal acquisition can be augmented by varying the strength B0 of the main magnetic field for at least a portion of the pulse sequence used to acquire the MR signal.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: November 27, 2018
    Assignee: SYNAPTIVE MEDICAL (BARBADOS) Inc.
    Inventors: Alexander Gyles Panther, Cameron Anthony Piron, Jeff Alan Stainsby, Chad Tyler Harris
  • Patent number: 10016413
    Abstract: The present invention is directed to a method of treating or preventing an addictive behavior in a subject, said method comprising administering to said subject an effective amount of a dopamine antagonist and a opiate receptor antagonist or a composition comprising same. Further provided are pharmaceutical compositions comprising, as active substances, at least one dopamine antagonist and at least one opiate receptor antagonist.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: July 10, 2018
    Assignee: University of Maryland, Baltimore
    Inventors: Jia Bei Wang, Sarah Sushchyk
  • Patent number: 10004422
    Abstract: A method for chemical exchange saturation transfer (“CEST”) imaging that is more insensitive to off-resonance and magnetization transfer effects than other CEST methods is provided. Sn general, three different images are obtained: one obtained with radio frequency (“RF”) saturation about a labeling frequency, one obtained with RF saturation about a reference frequency, and one obtained with RF saturation about both the labeling and reference frequencies. This method, termed saturation with frequency alternating radiofrequency irradiation (“SAFARI”), is also very robust to magnetic field inhomogeneities. The three images, referred to as a labeled image, reference image, and dual frequency image, are selectively combined to produce an image of the subject in which CEST contrast is present, but errors arising from off-resonance and magnetization transfer effects are substantially suppressed.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: June 26, 2018
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: David Alsop, Rachel Scheidegger
  • Patent number: 9983286
    Abstract: A magnetic resonance imaging (MRI) system, method and/or computer readable medium is configured reduce specific absorption rate (SAR) in Fast Advanced Spin Echo (FASE) or Single-shot Fast Spin Echo (SS-FSE) imaging used, for example, in non-contrast magnetic resonance angiography (NC-MRA) techniques like fresh blood imaging (FBI). Within RF pulse sequences used to acquire echo data, the refocusing flip angles may be varied in the phase encode direction, and/slice encode direction, such that the refocusing pulse (or pulses) that map echo signals to the k-space center region larger refocusing flip angles than refocusing pulses used to generate echo signals that map to other areas of k-space. In some instances, the TR interval also may be varied for RF pulse sequences such that central K-space have a longer TR than the slices further towards the ends.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: May 29, 2018
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Mitsue Miyazaki, Xiangzhi Zhou, Yoshimori Kassai
  • Patent number: 9974464
    Abstract: An image processing apparatus according to an embodiment includes a processor and a memory. The memory stores processor-executable instructions that, when executed by the processor, cause the processor to: receive an input of information designating an observation target; extract, from each of magnetic resonance (MR) images included in an MR image group collected by applying a tagging pulse to a region where a fluid flows, a group of regions of the fluid; analyze, by an analyzing method associated with the observation target, the group of regions of the fluid extracted from each of the MR images, thereby deriving an index indicating a dynamic state of the fluid; and cause the index to be displayed on a display.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 22, 2018
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Taichiro Shiodera, Shuhei Nitta, Tomoyuki Takeguchi
  • Patent number: 9974511
    Abstract: A medical imaging apparatus according to a present embodiment includes processing circuitry. The processing circuitry obtains pieces of medical image data, the pieces each being generated in each of multiple time phases and each including bone information. The processing circuitry sets first regions each being included in each of the pieces. The processing circuitry generates pieces of corrected medical image data by aligning the pieces of medical image data so that the first regions are substantially a same position. The processing circuitry specifies second regions each corresponding to a bone moving in the pieces of the corrected medical image data. The processing circuitry displays the second regions so as to be recognized on a display.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: May 22, 2018
    Assignee: Toshiba Medical Systems Corporation
    Inventor: Megumu Fujiwara
  • Patent number: 9968409
    Abstract: This system is a system for analyzing blood flow of a target vascular site by means of simulation, having a fluid analysis unit, by a computer, for determining state quantities of blood flow at each position of a lumen of the target vascular site by means of computation by imposing computational conditions including boundary conditions relating to the blood flow to three-dimensional shape data of the target vascular site; a three-dimensional shape modification unit for modifying the three dimensional shape data by simulating a surgical treatment method and for outputting the three-dimensional shape data after the modification; and a comparison display unit for displaying computed results of before and after the modification of the three-dimensional shape for comparing the results, by causing the fluid analysis unit to re-compute the state quantities based on the three-dimensional shape data after the modification.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: May 15, 2018
    Assignee: EBM CORPORATION
    Inventors: Takanobu Yagi, Young-Kwang Park
  • Patent number: 9964621
    Abstract: A method and apparatus for reducing scan time, eddy currents and image factors in dynamic magnetic resonance (MR) imaging associated with at least a portion a k-space. The method includes scanning at least a portion of the k-space with an Echo-Planar Imaging (EPI) pulse sequence technique, acquiring a randomly under-sampled k-space; and reconstructing the under-sampled k-space utilizing a constrained reconstruction technique. A dynamic image is constructed of the at least a portion of the k-space based on EPI and the randomly undersampled k-space techniques to each segment of the EPI pulse sequence technique.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: May 8, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Tamer Basha, Reza Nezafat
  • Patent number: 9915719
    Abstract: In a method and apparatus for recording magnetic resonance (MR) signals from an examination object, raw data space is filled with MR signals in raw data lines. Movement information of the examination object is detected during recording of the MR signals and the movement information is grouped into different movement phases of the examination object. A temporally randomly distributed sequence of the recording of the raw data lines is determined, with which at least one predetermined portion of the raw data space is filled MR signals. The MR signals are acquired in the determined temporally randomly distributed sequence of the raw data lines in the predetermined portion. Each recorded raw data line is allocated to one of the movement phases of the examination object.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: March 13, 2018
    Assignee: Siemens Healthcare GmbH
    Inventor: Stefan Popescu
  • Patent number: 9854990
    Abstract: The present disclosure relates to a brain disease diagnosis service apparatus including at least: a receiving unit for receiving an image of a subject to be diagnosed; a preprocessing unit for estimating a transformation matrix in order to align a predetermined standard image with the image received by the receiving unit, and for applying the estimated transformation matrix to a predetermined standard brain region map, thereby generating an individual brain region map for the subject to be diagnosed; a feature point extracting unit for calculating a ratio occupied by brain lesions for each brain region in the individual brain region map, generated by the preprocessing unit, of the subject to be diagnosed, thereby extracting feature points; and a disability type determining unit for determining a disability type on the basis of the ratio of the brain lesions, calculated by the feature point extracting unit, for each brain region.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: January 2, 2018
    Assignee: THE ASAN FOUNDATION
    Inventors: Dong Wha Kang, Yong Hwan Kim
  • Patent number: 9848850
    Abstract: A method of displaying stereoscopic information related to an ultrasound sectional plane of a target object includes setting a line of interest on the ultrasound sectional plane of the target object based on a received input; obtaining an ultrasound signal of the ultrasound sectional plane of the target object along the set line of interest; converting the obtained ultrasound signal to represent the stereoscopic information in a three-dimensional manner; and displaying the stereoscopic information related to the ultrasound sectional plane of the target object.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: December 26, 2017
    Assignees: SAMSUNG ELECTRONICS CO., LTD., SAMSUNG MEDISON CO., LTD.
    Inventors: Eun-jung Chang, Jin-yong Lee
  • Patent number: 9833166
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a specifying unit and an acquiring unit. The specifying unit specifies, on a basis of a detection result of target sites of a subject detected from an image on which the target sites are visualized, a first region and a second region which is different from the first region on the image. The acquiring unit acquires data of the second region by using an imaging condition which is different from an imaging condition on an imaging slice and used for acquiring data of the first region.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: December 5, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventor: Kensuke Shinoda
  • Patent number: 9693706
    Abstract: An image processing apparatus according to an embodiment includes a specifying unit and a deriving unit. The specifying unit specifies a fluid region in a plurality of magnetic resonance images that are acquired by applying a labeling pulse to a label region and that are mutually related. The deriving unit derives an index indicating dynamics of a fluid on the basis of the specified fluid region.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: July 4, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Taichiro Shiodera, Shuhei Nitta, Tomoyuki Takeguchi, Nobuyuki Matsumoto
  • Patent number: 9664764
    Abstract: An MRI system acquires a susceptibility-weighted image by acquiring a first RF echo signal in a first echo time for providing an image exclusive of susceptibility-weighting and acquiring a second RF echo signal in a second echo time longer than the first echo time for providing an image including susceptibility-weighting. A compensation gradient field is applied for compensating for field inhomogeneity and in response, a third RF echo signal is acquired in a third echo time longer than the second echo time. First, second and third images are generated in response to data derived from the first, second and third RF echo signals respectively and data of the first, second and third images is combined to provide image data representing an image compensating for magnetic resonance signal attenuation in the second image.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: May 30, 2017
    Assignees: Samsung Electronics Co., Ltd., The Trustees Of The University Of Pennsylvania
    Inventors: Jin Young Hwang, Joon Soo Kim, Jae Moon Jo, Yang Lim Choi, Jongho Lee
  • Patent number: 9649041
    Abstract: According to one embodiment, a blood flow perfusion analyzing apparatus includes tissue and arterial TCC calculation units, first and second making units, a deconvolution unit and a blood flow information calculation unit. The tissue TCC calculation unit obtains tissue TCCs. The arterial TCC calculation unit calculates an arterial TCC. The first making unit makes first sets, starting from a first time in which elements corresponding to the tissue are arrayed one-dimensionally, based on the tissue TCCs. The second making unit makes a second set, starting from a second time after the first time, in which elements corresponding to the artery are arrayed two-dimensionally, based on the arterial TCC. The deconvolution unit calculates transfer functions of the tissue based on the first and second sets. The blood flow information calculation unit calculates information on a blood flow perfusion based on the transfer functions.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: May 16, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Shigeharu Ohyu, Yasuo Sakurai
  • Patent number: 9613188
    Abstract: Systems for and methods of utilizing a neuroimaging database are presented. The systems and methods include techniques for analyzing the pathophysiological basis of a chronic brain disease and/or the effectiveness of a treatment for a chronic brain disease, obtaining data for research of a chronic brain disease, searching for chronic brain disease symptoms identified in a clinical patient, searching a database by comparing the brain scan images of patients with suspected indications of chronic brain disease with other patients in the database to identify sets of patients with similar indications in their brain scan images, displaying brain scan information regarding a person, and using image pattern matching to analyze the pathophysiological basis of a chronic brain disease and/or the effectiveness of a proposed or previously administered treatment for a chronic brain disease.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: April 4, 2017
    Assignee: CERESCAN CORPORATION
    Inventors: Vincent Bradshaw, Theodore Henderson, Jennifer Faherty, Donald Bitto, Nikki Villegas-Mauter
  • Patent number: 9579041
    Abstract: A magnetic resonance imaging (MRI) system semi-automatically performs non-contrast magnetic resonance angiography (MRA). An operator display and control input port configures the MRI system to effect semi-automated non-contrast MRA imaging with spatially selective tag and venous suppression RF pulses and/or black blood time interval (BBTI) parameters in a non-contrast MRA data acquisition sequence where such parameters are automatically determined within predetermined, respectively corresponding, spatial regions of patient anatomy. Such automatically determined non-contrast MRA imaging parameters may be entirely automatically set and used or, alternatively, may be displayed to an operator for acceptance and/or change before being used.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: February 28, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventor: Mitsue Miyazaki
  • Patent number: 9551565
    Abstract: A method and corresponding system for optical coherence tomography includes optical coherence tomography equipment that acquires at least two two-dimensional initial images of an object in planes of the object that are spaced apart from one another, in particular running parallel to one another, wherein the initial images each include a plurality of initial image values. In order to assure an examination of the object in the case of medical applications that is as reliable as possible, an interpolation of the initial image values of the at least two two-dimensional initial images is performed in three-dimensional space, wherein interpolation values are obtained that form a two-dimensional final image.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 24, 2017
    Assignee: AGFA HEALTHCARE NV
    Inventors: Rainer Nebosis, Roland Reuter
  • Patent number: 9545206
    Abstract: Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: January 17, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Mitsue Miyazaki, Xiangzhi Zhou, Tsutomu Hoshino