Abstract: The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

Abstract: Disclosed is a system and method for registering images from two medical imaging modalities in a six-degree-of-freedom coordinate space, for the purpose of providing real time registered imagery for optimization of medical procedures. The system and method uses fiducial that is visible to the first imager and in a fixed position and orientation relative to the second imager. The first imager may be an X-ray device such as a C-arm fluoroscope, and the second imager may be a Transrectal Ultrasound (TRUS) device.

Abstract: An image display apparatus includes a first radiographic image acquirer for acquiring a first radiographic image captured in the scout image capturing process, a second radiographic image acquirer for acquiring a plurality of second radiographic images captured in the stereographic image capturing process, a first display controller for displaying the first radiographic image on a display unit, and a second display controller for displaying the second radiographic images on the display unit and, in case that the biopsy region is selected in the displayed first radiographic image, displaying, in the second radiographic images, respective guide lines passing through positions in the second radiographic images which correspond to the position of the biopsy region selected in the first radiographic image and extending parallel to or substantially parallel to a prescribed direction.

Abstract: A bone marker device for use in surgery. The device has attachment means which is/are attachable to bone that will ultimately be resected during the surgery. A guiding device that is removably securable to the bone of a patient adjacent to the joint and on which the bone marker device may be mounted. A guide member of the guiding device has a slot for receiving a bone resector and enabling accurate resection of bone around the joint.

Abstract: A surgical procedure is provided. The procedure acquires a plurality of points on or near a bone abnormality and registers them with a surgical navigation system. The navigation system uses the acquired points to make an implant having a surface adapted to contact the bone, and particularly an implant having a portion whose shape substantially matches that of the bone abnormality.

Abstract: A system (100) includes a CT scanner (101) with a radiation source (108) that emits radiation the traverses an examination region (112), a radiation sensitive detector array (110), located opposite the source across the examination region, which detects radiation traversing the examination region and a portion of a subject therein and generates a signal indicative thereof, and a subject support (114) that positions the subject in the examination. A HIFU apparatus (124) includes an ultrasound probe (126). A main controller (142) controls an operation of both the CT scanner and the HIFU apparatus. A treatment navigator (140) visually presents, in a graphical user interface, CT data of a location of the ultrasound probe with respect to at least one fiducial marker of the HIFU apparatus and obtained by the CT scanner overlaid over a previously generated HIFU procedure plan.

Abstract: A detector of a gamma camera is configured such that a radioactive point source is positioned within a field of view at a fixed distance from the detector. A predetermined number of gamma photons emitted by the point source and passed through a collimator are acquired. A system-specific planar sensitivity is computed for a combination of the collimator and detector using the number of gamma photons acquired, a time duration of the acquisition, and precalibrated radioactivity data of the point source corrected for decay that occurred after a precalibration time. A deviation of the computed system-specific planar sensitivity from a class standard sensitivity value for a combination of the radioactive point source, the collimator, and the detector is computed. A class standard sensitivity value for a combination of a radiopharmaceutical, the collimator, and the detector is scaled by the computed deviation, yielding a scaled system-specific sensitivity value for the radiopharmaceutical.

Abstract: Diffuse fluorescence flow cytometers and methods of using them include a plurality of excitation sources and a plurality of detectors, all circumferentially arranged about a space for accommodating a limb of a subject. Tomographic reconstructions of cells within the limb are made by varying the intensity and direction of excitation and then analyzing the results.

Abstract: Method to process a set of tomosynthesis slices, comprising; acquiring images of an object of interest using a detector of a machine also comprising an X-ray emitter; reconstructing a set of tomosynthesis slices of the object using a calculator, in relation to the acquired images; displaying slices on a display monitor with a first display increment; selecting a region of interest in a slice of interest; and using a second display increment that is finer than the first display increment to display on the display monitor regions of interest belonging to slices in the set, the regions of interest corresponding to the selected region of interest.

Abstract: The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. for imaging of the body of a mammal. Also described are kits comprising such formulations and imaging methods utilizing such formulations or kits.

Abstract: A medical method includes: obtaining marker positions at a plurality of time points; determining a first subset of the marker positions that belongs to a first phase bin; using the marker positions in the first subset to determine a first variance information, wherein the first variance information is determined using a processor; and storing the first variance information in a non-transitory medium.

Abstract: A substrate configured for placement on an internal organ or internal tissue is provided. In certain embodiments, the substrate conforms to and moves with the internal organ or internal tissue. Three or more sensor elements are integrated on the substrate. In one implementation, the substrate and associated sensor elements provide dynamic referencing of the internal organ or internal tissue after registration of the sensor data with images and/or volumetric representations of the internal organ or internal tissue.

Abstract: An intracorporeal marker includes a fibrous unitary marker body having bioabsorbable fibers compressed into a compressed configuration, and bound in the compressed configuration by a polymer binding agent. The intracorporeal marker may be incorporated into an intracorporeal marker delivery device having a delivery cannula which has a distal tip, an inner lumen and a discharge opening in communication with the inner lumen. The compression and binding occur prior to insertion of the fibrous unitary marker body into the inner lumen of the delivery cannula. The fibrous unitary marker body is slidably disposed within and pushable through the inner lumen of the elongated delivery cannula proximal to the discharge opening.

Abstract: A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.

Abstract: A method for bringing an IVUS and an OCT image into register. In one embodiment, the method includes obtaining an IVUS image of an area of a lumen; obtaining an OCT image of the same area of the lumen; determining the same asymmetry in each of the IVUS and OCT images; and overlaying the IVUS and OCT images and rotating them with respect to one another until the asymmetry in each of the IVUS and OCT images are in register, and determining the angle of rotation that resulted in the registration. In another aspect, the invention relates to a probe for OCT and IVUS imaging. In one embodiment, the probe includes a sheath having a first end and a second end defining a lumen; a marker that is opaque to light and ultrasound located between the first end and second end; and an IVUS/OCT probe head positioned within the sheath.

Abstract: A dual modality probe is disclosed having both a positron emission tomography sensor and a ultrasound sensor. A dual imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from said positron emission sensor and said ultrasound sensor of said probe and said positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

Abstract: A probe is disclosed having a positron emission tomography sensor. An imaging system is provided having the probe and at least one external positron emission tomography detector and a data acquisition computer system for collecting data simultaneously from said positron emission sensor of said probe and said positron emission tomography detector. A method for evaluating a target organ of a patient utilizing the probe and imaging system, and performing a biopsy of the organ is disclosed.

Abstract: The present invention provides particulate contrast media for use in CT imaging. The contrast media are based on particles of low-Z elements. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising essentially water-insoluble particles of a material selected from microparticles and nanoparticles. Exemplary particles comprise a material comprising a plurality of atoms of an element with an atomic number from 6 to 52. In various embodiments, the particles are coated with a material compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast medium is incorporated into a pharmaceutically acceptable vehicle in which the particles are suspended.

Abstract: A method for providing a representation of the distribution, fluctuation and/or movement of electrical activity through heart tissue, said method comprising: obtaining an ECG of the heart comprising said tissue; obtaining a model of the heart geometry; obtaining a model of the torso geometry; relating the measurements per electrode of the ECG to the heart and torso geometry and estimating the distribution, fluctuation and/or movement of electrical activity through heart tissue based upon a fastest route algorithm, shortest path algorithm and/or fast marching algorithm.

Abstract: A method and apparatus for allowing determination of patient position change relative to an imaging device and/or allowing digital subtraction in an operative position. The system can include devices for determining a position of a patient at various times and comparing the various positions of the patient. Further, a digital subtraction may be performed if the patient change is not above a threshold value and/or if motion correction can occur.

Abstract: The present invention includes a method of pre-planning a spherical fixed point stereotactic radiosurgery by obtaining an image from a patient having a target, the image comprising coordinates of the actual patient target in 3 dimensions on a first day; planning an optimal stereotactic radiosurgery using the patient's actual target using actual coordinates in 3 dimensions prior to the day of surgery by creating virtual radiosurgical coordinates and plans to maximize target exposure and minimize the patient's waiting time in radiosurgery, thereby allowing evaluation of several plans to maximize plan conformality and safety; and treating the patient based on the virtual stereotactic radiosurgery plans on a second day.

Abstract: A method and apparatus for precisely reproducing the position of a vaginal cylinder in relation to a patient to ensure that a planned radiation dose can be delivered with high precision to the intended treatment target volumes. Treatment delivery is carried out by using an image-guided system to locate the position of the vaginal cylinder and comparing it to the coordinate of the vaginal cylinder obtained in the treatment plan. The displacement in the position of the vaginal cylinder from the treatment plan is corrected by calculating the transformation matrix and entering the resulting value into a position adjusting assembly which is attached to vaginal cylinder. The position adjusting assembly adjusts the vaginal cylinder to exactly reproduce its location relative to the patient's anatomy, eliminating geometric and dosimetric error.

Abstract: A system for determining a functional property of a moving object includes a tag contactable to the object such that the tag follows the movement of the object. The system further includes a movement determination device configured to determine the movement of the tag. The system also includes a functional property determination device configured to determine a functional property of the object from the determined movement of the tag.

Abstract: Landmark directional guidance is provided to an operator of an endoscopic device by displaying graphical representations of vectors adjacent a current image captured by an image capturing device disposed at a tip of the endoscopic device and being displayed at the time on a display screen, wherein the graphical representations of the vectors point in directions that the endoscope tip is to be steered in order to move towards associated landmarks such as anatomic structures in a patient.

Abstract: In part, the invention relates to fiduciary markers suitable for affixing to a patient that are detectable with respect an imaging modality such as MRI and methods of making the same. The markers include a paramagnetic material disposed therein that generates a distinguishable signal relative to a patient or other biological sample of interest during an imaging data collection session. Further, the markers demonstrate desirable signal to noise ratios across two or more MRI data collection procedures in one embodiment. The length of the markers is also adjustable by, for example, cutting or tearing a substrate upon which a substantially fluid-free region straddles a specified separation position on the substrate.

Abstract: A system for tracking the position of an instrument relative to an area of interest includes a first fixator configured to carry first and second localizing devices. A second fixator is configured to carry the first localizing device. A third localizing device communicates with the first localizing device and the second localizing device communicates with the first localizing device such that the position of the second localizing device can be determined relative to the position of the third localizing device. The second localizing device is attachable to the instrument and the first localizing device is attachable to the first fixator such that the first localizing device communicates with the second localizing device on the instrument in order that the position of the second localizing device on the instrument can be determined relative to the third localizing device.

Abstract: There is disclosed a method of extracting large scale biological, biochemical or molecular information about an index disease, biological state, or systems from imaging by correlating the imaging features associated with said disease, state or system with corresponding large scale biological data.

Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.

Abstract: A method for predefining a set of radioactive-emission measurement views, for radioactive-emission imaging after an administration of a radiopharmaceutical, the method being tailored to a specific body structure and optimized with respect to the information gained about the body structure and based on modeling body-structure, based on its geometry and anatomical constraints, which limit accessibility to the body structure.

Abstract: The present disclosure relates to acquiring image data of a subject and selecting image data to be displayed. The image data can include a plurality of frames that relate to a specific location of a tracking device positioned within the subject. The determined location of the tracking device can be used to determine which frame of the image data to display at a selected time.

Abstract: A system and apparatus allows the tracking of a selected body portion, instrument, or both. A tracking device can be interconnected to a body portion at a mounting site. A procedure can be performed at a location remote from the mounting site of the tracking device. The tracking device can be interconnected with the body in a low invasive manner.

Abstract: The present invention is an apparatus and method to produce an image of an eye of a patient that includes an optical head that includes imaging optics, illumination source optics and a camera housing with a perimeter that houses the video camera optics and the illumination source optics, a slit lamp chinrest and joystick assembly that includes an adjustable head support, a movable base, a joystick that adjusts a position of the camera housing relative to the head support and the housing support that mounts the video camera, a rubber eyecup that provides an interface between the camera housing and the patient's eye that protrudes outward from the perimeter and a computer system that analyzes images and data for the presence of amyloid in a retina, and other deposits and provides a diagnosis of macular degeneration, Alzheimer's disease, traumatic brain injury, multiple concussive injury, neurodegenerative and other ocular disorders.

Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transarterial attenuation gradient for the coronary artery of the patient. The patient specific transarterial attenuation gradient is compared to previously collected data to determine an estimate of a pressure gradient and/or fractional flow reserve (FFR) for the patient. As more data is collected, the data can be added to the database in order to increase the accuracy of future assessments. The database can also be enhanced by adding data generated by canonical models and mathematical analysis.

Abstract: A method for determining by an x-ray projection a position of a target radiopaque marker disposed on a catheter in a subject's body, comprising assigning a landmark in the body as a reference point compensated for periodic movements of the body, determining an auxiliary location relative to the reference point using at least one additional radiopaque marker disposed on the catheter and based on the auxiliary location determining the position of the target radiopaque marker with respect to the reference point.

Abstract: A method and system for identifying a portion of an image data is disclosed. The image data can include image data of an anatomy, such as a brain of a patient. The identified portion can be used for planning a procedure. The identified portions can include anatomical landmarks that can be used to determine anatomical targets of the patient. The plan can include a path or trajectory to reach the anatomical target.

Abstract: A fiducial marker system (210a-c) comprises a first unit and a second unit. The first unit is patient affixable and comprises a partly spherical inner surface having a first center point that is adapted to receive a touch probe measurement head for measuring the spatial position of the center point. The second unit is releasably attachable to an outer surface of the first unit, and has a second center point, wherein the first center point and the second center point are substantially identical when the second unit is attached to the first unit. For stereotactic therapy, a patient is imaged with the first and second unit assembled. Then the second unit is detached. A stereotactic frame (300) is attached to the first units via arms. Thus frameless imaging is provided in a frame based stereotactic surgery system with high precision. Repeated assembly of the frame (300) to the first units, remaining in the patient, provides advantageous fractionized stereotactic radiotherapy.

Abstract: An implantable applicator (10) has at least one guide channel (12) for guiding a radioactive seed or source (66) to a target region. A plurality of imageable fiducials (40) are configured for attachment to the patient adjacent the target region. Electromagnetic sensors (18, 20, 22, 20?, 42) are mounted to the applicator and the imageable fiducials. An electromagnetic tracking system determines the relative position of the applicator mounted sensors (18, 20, 22, 20?) and the fiducial mounted sensors (42). A localizing processor (52) generates a map of the sensors which is combined (56) with a high resolution image (46). A comparing processor (70) monitors for changes in sensor positions, generates a movement correction transform (72) which transforms (74) the planning image into a transformed planning image (76).

Abstract: An intracorporeal site marker has high ultrasound reflectivity, presents a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The biopsy site marker may include features to fix the marker to the biopsy site so as to resist migration from the biopsy cavity.

Abstract: A planning method and device for knee implants, wherein spatial data on the configuration of a patient's genicular anatomy, in particular of at least a part of the femur and/or the patella and/or the tibia, are captured in order to be inputted into a computer-assisted planning station; the movement of the parts of the genicular anatomy is recorded using a tracking and/or motion capturing method; the captured anatomical and movement data are made available to the computer-assisted planning station; a part of the patient's genicular anatomy is virtually replaced in the planning station by a sample implant and movements of the knee together with the sample implant are simulated; contact and impingement between the non-replaced parts of the genicular anatomy and the implant during the virtual movement is ascertained according to its magnitude; and wherein an adjustment of the positioning, shape or orientation of the implant or of a number of these parameters is determined until the contact and impingement become

Abstract: A magnetic resonance tomography device has a local coil that is fashioned to receive a magnetic resonance signal. This device has a detector system that is fashioned to detect a position of the local coil on the basis of electromagnetic waves that are affected by the position of the local coil and can be differentiated from the magnetic resonance signal. A method to detect a position of a local coil in a magnetic resonance tomography device Is implemented in this manner as well.

Abstract: In one embodiment of the invention, an apparatus includes a display device. The display device displays a desaturated image of tissue captured in the visible electro-magnetic (EM) spectrum from a body cavity; and a first color enhanced image combined with the desaturated image. The first color enhanced image represents the first data captured from the body cavity outside the visible electromagnetic spectrum. The relative brightness between the desaturated image and the first color enhanced image is set to emphasize the first data over the tissue captured in the visible electromagnetic spectrum to provide improved information content.

Abstract: A method of compensating for breathing and other motions of a patient during treatment includes periodically generating internal positional data about an internal target region. The method further includes generating external positional data about external motion of the patient's body using an external sensor and generating a correlation between one or more positions of the internal target region and one or more positions of an external region using the external positional data of the external sensor and the internal positional data of the internal target region. The method further includes predicting the position of the internal target region at some later time based on the correlation model.

Abstract: An apparatus and method for placing a device in a body area of a patient, by: tracking the device over a 3-dimensional model of the body area; activating the device at different locations in the body area; measuring the response signal or parameter caused by the activation; storing the locations as well as the response signals; choosing an optimal location for the device base in the stored response signals and navigating the device to the optimal location.

Abstract: A navigation system for use during a surgical procedure is provided. The navigation system is configured to use electromagnetic tracking data produced by electromagnetic tracking devices and 2D image data produced by a fluoroscope to intra-operatively register 2D images of a patient to a pre-operative 3D image of the patient. In some implementations, a surgeon may be able to perform an interventional or surgical procedure guided by the navigation system.

Abstract: Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.

Abstract: Generating, with respect to each of the three-dimensional image and the three-dimensional comparison image, a plurality of tomographic images orthogonal to a central axis of each vertebra of the subject along the central axis, calculating a first characteristic amount representing a profile in a direction orthogonal to the central axis at each point on the central axis based on the tomographic images, calculating a second characteristic amount representing a profile in a direction of the central axis at each point on the central axis based on the tomographic images, calculating a third characteristic amount representing regularity of disposition of each vertebra at each point on the central axis based on the calculated first and second characteristic amounts, and aligning positions of the third characteristic amount calculated from the three-dimensional image and the third characteristic amount calculated from the three-dimensional comparison image along the central axis.

Abstract: A system and method combines information from a plurality of medical imaging modalities, such as PET, CT, MRI, MRSI, Ultrasound, Echo Cardiograms, Photoacoustic Imaging and Elastography for a medical image guided procedure, such that a pre-procedure image using one of these imaging modalities, is fused with an intra-procedure imaging modality used for real time image guidance for a medical procedure for any soft tissue organ or gland such as prostate, skin, heart, lung, kidney, liver, bladder, ovaries, and thyroid, wherein the soft tissue deformation and changes between the two imaging instances are modeled and accounted for automatically.

Abstract: A surgical navigation system is disclosed including a camera that is fixedly attached to a patient. The camera space merges with the patient space and thereby eliminates the need for a separate patient tracker. The surgical navigation system calculates the position of a surgical tool with a tracking device in view of the camera and shows on a display device the position of the surgical tool with respect to the patient superimposed and in correlation with a scan image of the patient.

Abstract: The invention includes both a method for acquiring the position of a patient's anterior pelvic plane, and a patient positioner or holder (apparatus) for securing a patient and acquiring the position of the patient's anterior pelvic plane. The method and apparatus facilitate definition of the anterior pelvic plane (APP) in the context of computer assisted hip surgery.

Abstract: A medical image processing apparatus has a parameter calculating unit, a storage unit, and an image generating unit. The parameter calculating unit analyzes data of a plurality of time-series medical images, each containing an image of an organ having a functional blood vessel and a feeding blood vessel, and calculates a parameter based on at least a blood volume in the feeding blood vessel. The storage unit stores in advance a table that associates parameters with degrees of a cancer progression of the organ. The image generating unit refers to the table, obtains a degree of the cancer progression corresponding to the calculated parameter, and generates an image to which the obtained degree is applied on a region-by-region basis.