Abstract: A method of producing an artificial neural network capable of predicting the survivability of a patient, including: storing in an electronic database patient health data comprising a plurality of sets of data, each set having at least one of a first parameter relating to heart rate variability data and a second parameter relating to vital sign data, each set further having a third parameter relating to patient survivability; providing a network of nodes interconnected to form an artificial neural network, the nodes comprising a plurality of artificial neurons, each artificial neuron having at least one input with an associated weight; and training the artificial neural network using the patient health data such that the associated weight of the at least one input of each artificial neuron is adjusted in response to respective first, second and third parameters of different sets of data from the patient health data.

Abstract: A medical device includes a housing and an electrode arrangement coupled to the housing and configured to sense an electrical physiologic signal from a patient. The device also includes detection circuitry coupled to the electrode arrangement and configured to obtain a cardiac signal component and a non-cardiac signal component from the physiological signal. A processor is coupled to the detection circuitry. The processor is configured to detect patient activity using at least the non-cardiac signal component and discriminate between voluntary and involuntary activity of the patient based on a comparison of temporally aligned cardiac and non-cardiac signal components.

Abstract: The invention relates to systems and methods for three dimensional imaging of tissue. The invention provides systems and methods to provide a representation of tissue from three-dimensional data that includes intravascular imaging data as well as data representing a shape of the intravascular imaging probe. Device of the invention combine a shape-sensing mechanism with an intravascular intervention catheter.

Abstract: A computer-implemented method for providing summary information for lifesaving activities is disclosed. The method involves sensing one or more activities that are repeatedly and cyclically performed on a victim by a rescuer; identifying a cyclical timing interval over which performance is to be analyzed for a integer number of cycles of the one or more activities, and gathering data from the sensing of the one or more activities during the time interval; generating, from analysis of the one or more activities, summary data that condenses data sensed for the one or more activities into a summary of the one or more activities; and providing, for display to a user, a visual summary of the performance of the one or more activities over the identified time interval.

Abstract: An apparatus for evaluating a vascular endothelial function includes: a cuff, to be wound around a part of a body of a subject; a cuff pressure controller, configured to control a pressure of the cuff, and configured to apply continuous pressure stimulation; a cuff pressure detector, configured to detect the pressure of the cuff from output of a pressure sensor connected to the cuff; a pulse wave detector, configured to detect, from the output of the pressure sensor, pulse waves before and after the continuous pressure stimulation is applied; and an analyzer, configured to evaluate the vascular endothelial function by comparing the pulse waves detected before and after the continuous pressure stimulation is applied.

Abstract: Disclosed herein are methods, systems, and apparatus for detecting an epilepsy event in a patient using a medical device. The medical device is capable of determining an occurring epilepsy event, for example a seizure or an increased risk of a seizure. The determination is performed by determining at least one NNXX value from the beat sequence of the patient's heart. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and treating the epilepsy event.

Abstract: A method for locating a catheter tip within a human body is disclosed. An audio sensor is positioned at a site on the human body. An audio signal is detected by the audio sensor, and transmitted to an audio signal processing unit. The audio signal processing unit determines if the audio signal corresponds to a target location of the catheter tip, and transmits a notification signal to a user notification unit. An infusion of fluid or an audio emitting element can be used to generate the audio signal at the catheter tip.

Abstract: A mobile system for a user includes a telephone having one or more sensors to capture fitness data or vital sign data, the telephone having a wireless transceiver coupled to the processor to communicate fitness or vital sign data over a personal area network; and a processor coupled to the personal area network to process the fitness or vital sign data.

Abstract: A cardiac implant includes a classifier configured analyze the data for comparison to thresholds prioritized according to a Boolean decision tree. The implant can generate an indicator of alert status (i.e., alert or no alert). A supervisory device operated, for example, by a doctor can associate each indicator a marker (AE/no AE) indicating the presence or absence of an observed adverse event. In the presence of a false positive, a command for update of the thresholds of the decision tree is transmitted to the implant. A database of reference patients can be used to recreate or further update the decision tree to avoid the occurrence of false negatives.

Abstract: A personal health monitor device comprising memory for collecting and storing attributes from an individual and a processor for quantizing each attribute in such a way as to indicate a normal range for that attribute and for measuring deviations from that normal range. The processor further calculates the well-being of the individual using the deviations measured. The results are displayed indicating the well-being of the individual.

Abstract: Devices and methods for detecting events indicative of heart failure (HF) decompensation status are described. An ambulatory medical device can determine the present physiologic state as being either a drift state or a stable state, and applies an algorithm to detect HF decompensation event according to the physiologic state. In some embodiments, the ambulatory medical device uses the present physiologic state to estimate one ore more expected future signal characteristics, and to detect HF decompensation event using the one or more expected futures signal characteristics.

Abstract: A computer-implemented electronic messaging method and system, the method comprising the steps of receiving an electronic message at a first system, the electronic message comprising a caregiver type, obtaining contextual information associated with the electronic message at the first system, using the caregiver type and the contextual information to identify an intended caregiver recipient address for an intended caregiver recipient for the electronic message and providing the intended caregiver recipient address to facilitate delivery of the electronic message to the intended caregiver recipient.

Abstract: Methods for noninvasively determining a pulmonary capillary blood flow or a cardiac output of a subject include determining data of the amount of gas exchanged between blood and gas in lungs of the subject, as well as data of an indicator of the content of the gas in blood of the subject. Such a determination may be made during two or more different states of ventilation. A geometric relationship is identified between data points, with any data points outlying the geometric relationship being disregarded. The remaining data points may be used to estimate or calculate a measure of pulmonary capillary blood flow or cardiac output. Systems that include elements that are configured to effect such methods are also disclosed.

Abstract: A cardiovascular parameter such as cardiac output is estimated from a current pressure waveform data set without needing to directly measure blood flow or arterial compliance. The general shape of an input flow waveform over one beat-to-beat cycle is assumed (or computed), and then the parameters of a flow-to-pressure model, if not pre-determined, are determined using system identification techniques. In one embodiment, the parameters thus determined are used to estimate a current peripheral resistance, which is used not only to compute an estimate of the cardiovascular parameter, but also to adjust the shape of the input flow waveform assumed during at least one subsequent beat-to-beat cycle. Another embodiment does not require computation of the peripheral resistance and still another embodiment computes a flow estimate from an optimized identification of the parameters defining the assumed input flow waveform.

Abstract: A system for determining a functional property of a moving object includes a tag contactable to the object such that the tag follows the movement of the object. The system further includes a movement determination device configured to determine the movement of the tag. The system also includes a functional property determination device configured to determine a functional property of the object from the determined movement of the tag.

Abstract: Embodiments of the present disclosure relate to a system and method for determining a likelihood of successful ventilator weaning for a patient undergoing mechanical or assisted ventilation. Specifically, embodiments provided herein include methods and systems for determining or predicting weaning readiness in a patient based on physiological parameters determined via photoplethysmography.

Abstract: A monitor device and associated methodology are disclosed which provide a self contained, relatively small and continuously wearable package for the monitoring of heart related parameters, including ECG. The detection of heart related parameters is predicated on the location of inequipotential signals located within regions of the human body conventionally defined as equivalent for the purpose of detection of heart related electrical activity, such as on single limbs. Amplification, filtering and processing methods and apparatus are described in conjunction with analytical tools for beat detection and display.

Abstract: Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.

Abstract: A monitor device and associated methodology are disclosed which provide a self contained, relatively small and continuously wearable package for the monitoring of heart related parameters, including ECG. The detection of heart related parameters is predicated on the location of inequipotential signals located within regions of the human body conventionally defined as equivalent for the purpose of detection of heart related electrical activity, such as on single limbs. Amplification, filtering and processing methods and apparatus are described in conjunction with analytical tools for beat detection and display.

Abstract: A portable blood pressure measuring apparatus and a method therefor are provided. In the portable blood pressure measuring apparatus, a blood pressure measurer measures a wrist or finger blood pressure being an arterial pressure at a wrist or a finger, a Pulse Wave Velocity (PWV) measurer measures a PWV, a controller controls compensation of the wrist or finger blood pressure using the PWV so that the wrist or finger blood pressure corresponds to a brachial blood pressure, and a display displays the compensated wrist or finger blood pressure.

Abstract: A system for determining onset of an acute hypotensive episode, the system includes a plurality of collectors configured to determine heart rate, mean arterial pressure, stroke volume, total peripheral resistance, and/or age of a patient, an estimate model configured to receive data from the collectors, a simulate model configured to receive information from the estimate model to simulate operation of an effector portion and a neural portion of an arterial baroreceptor reflex pathway, and a prediction model configured predict onset of an acute hypotensive episode based on results from the simulate model. A method and a computer software code for determining onset of an acute hypotensive episode are also disclosed.

Abstract: Disclosed are methods of reducing the risk that a medical treatment comprising inhalation of nitric oxide gas will induce an increase in pulmonary capillary wedge pressure in the patient, leading to pulmonary edema.

Abstract: Methods, systems and devices efficiently identify cardiac resynchronization therapy (CRT) pacing parameter set(s) that provide improved hemodynamic response relative to an initial CRT pacing parameter set, wherein each CRT pacing parameter set includes at least two CRT pacing parameters. User input(s) are accepted that specify a maximum amount of time and/or parameter sets that can be used to perform testing, and specify relative importance of parameters within the sets. Based on the accepted user input(s), there is a determination of how many different variations of each of the CRT pacing parameters can be tested, and based on this determination different CRT pacing parameter sets are selected and tested to obtain a hemodynamic response measure corresponding to each of the different sets tested. Additionally, one or more of the tested CRT pacing parameter sets, if any, that provide improved hemodynamic response relative to the initial CRT pacing parameter set is/are identified.

Abstract: Apparatus and methods for vibro-acoustic detection of cardiac conditions are disclosed. An example method includes calculating a frequency difference between a first frequency of a first cardiac signal and a second frequency of a second cardiac signal; calculating an amplitude difference between the first cardiac signal and the second cardiac signal; calculating a root-mean-square value based on a difference between the first cardiac signal and the second cardiac signal; calculating a value based on the frequency difference, the amplitude difference, and the root-mean-square value; and detecting a cardiac condition based on the value.

Abstract: In specific embodiments, a method to monitor pulmonary edema of a patient, comprises (a) detecting, using an implanted posture sensor, when a posture of the patient changes from a first predetermined posture to a second predetermined posture, (b) determining an amount of time it takes an impedance signal to achieve a steady state after the posture of the patient changes from the first predetermined posture to the second predetermined posture, where the impedance signal is obtained using implanted electrodes and is indicative of left atrial pressure and/or intra-thoracic fluid volume of the patient, and (c) monitoring the pulmonary edema of the patient based on the determined amount of time it takes the impedance signal to achieve the steady state after the posture of the patient changes from the first predetermined posture to the second pre-determined posture.

Abstract: The mental state of an individual is obtained to determine their well-being status. The mental state is derived from an analysis of facial information and physiological information of an individual. The well-being status of other individuals is correlated to the well-being status of the first individual. The well-being status of the individual or group of individuals is rendered for display. The well-being status of an individual is used to provide feedback and to recommend activities for the individual.

Abstract: Methods, systems, and apparatus for assessing a state of a comorbidity associated with a primary disease are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of a body system of the patient that is a site of the comorbidity, based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

Abstract: An implantable medical device system and method provide physiological variable monitoring for use in patient management. A target value for a physiological variable and formulations for computing metrics of the physiological variable are stored. Values of the physiological variable are determined from a sensed physiological signal and are used to compute a selected metric. The metric is compared to the stored target value.

Abstract: In accordance with an embodiment of the present technique, there is provided methods and systems for detecting the location of a sensor and determining calibration algorithms and/or coefficients for calculation of physiological parameters based on the detected location. An exemplary embodiment includes receiving a signal corresponding to absorption of at least one wavelength of light by a patient's tissue, generating a plethysmographic waveform from the signal, determining an identifying characteristic of the plethysmographic waveform, and determining a location of the sensor based on a comparison of the identifying characteristic with at least one defined criterion.

Abstract: Methods, systems, and apparatus for powering and/or recharging medical devices implanted within the body are described. An illustrative power generation module disposable within the interior space of an implantable medical device includes a module body that defines an interior cavity as well as a flexible diaphragm that spans the interior cavity. The flexible diaphragm includes a first electrical conductor, a piezoelectric layer disposed adjacent to the first electrical conductor, and a second electrical conductor disposed adjacent to the piezoelectric layer. The piezoelectric layer is configured to displace within the interior cavity and generate a voltage differential between the first electrical conductor and the second electrical conductor.

Abstract: A monitoring system includes a wearable eyeglass, band, belt, patch or bandage appliance; and a processor coupled to the wearable eyeglass, band, belt, patch or bandage appliance to analyze vital data or wellness data.

Abstract: A method for performing a patient oxygenation test using one or more computing devices is provided. The patient oxygenation test comprises a plurality of instructions for implementing a workflow for determining an oxygenation status for a patient. An entry or selection is received of one or more physiological parameters for the patient to be monitored during the patient oxygenation test. An entry or selection is received of one or more thresholds for at least one of the physiological parameters to be monitored during the patient oxygenation test. A determination is made as to whether any of the physiological parameters exceed limits set by the one or more thresholds. One or more actions are taken when one or more of the physiological parameters exceed the limits set by the one or more thresholds. A summary and analysis are provided of the test results.

Abstract: Mouth guards having electrodes, sensors, and/or accelerometers for determining one or more physiological conditions of a subject. Processing circuitry receives the outputs of the electrodes, sensors, and/or accelerometers. Optionally, at least a portion of the processing circuitry can be positioned within a helmet that is worn by a subject. The mouth guard can optionally be tethered to the helmet.

Abstract: A method and system for determining the state of a patients brain under anesthesia. The present invention recognizes that anesthesia compounds induce different signatures in physiological characteristics of the patient under anesthesia and aids interpretation of physiological characteristics and signatures therein based on a selected anesthesia compound. The present invention aids the monitoring and/or interpreting of the physiological characteristics to a state of the patient's brain.

Abstract: The invention provides a sensor for measuring both impedance and ECG waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ECG system that includes an analog ECG circuit, in electrical contact with at least two ECG electrodes, that generates an analog ECG waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform. Also included in the neck-worn system are a digital processing system featuring a microprocessor, and an analog-to-digital converter. During a measurement, the digital processing system receives and processes the analog ECG and impedance waveforms to measure physiological information from the patient. Finally, a cable that drapes around the patient's neck connects the ECG system, impedance system, and digital processing system.

Abstract: An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR.

Abstract: Methods of generating an extended cluster are disclosed. A first cluster including data representative of a first signal indicative of an abnormal physiological symptom is generated. A second signal is detected as representing a second abnormal physiological symptom and the second abnormal physiological symptom continues after the first abnormal physiological symptom ends. An extended cluster including the data from the first signal and the second signal is generated that extends from the time when the first abnormal physiological symptom occurs to the time when the second abnormal physiological symptom ends. The first and the extended cluster may include data of both the first and second signals the entire period of the clusters. If desired, the first signal or the second signal may be provided from a sensor implanted in a patient's brain tissue.

Abstract: A method of monitoring sleep of a sleeping subject is disclosed. The method comprises determining a phase shift of input radiofrequency signals received from the subject during sleep relative to output radiofrequency signals transmitted to the subject during sleep, calculating cardiac output based on the phase shift, and using the cardiac output for identifying sleep apnea events.

Abstract: A medical blood pressure transducer that provides an identifier to a monitor that conveys characteristics of the transducer. The monitor can use the information to decide whether to function, or in calibration of the system. The transducer may be part of a disposable blood pressure monitoring system, and may include two transducers closely-spaced to provide two separate but identical outputs. In this way, the transducer may be connected to both a patient monitor and a cardiac output monitor at the same time measurements from a single line can be simultaneously supplied to two separate monitoring devices (for example a patient monitor and a cardiac output monitor). The identifier for the transducer may be circuitry, specifically a resistance/capacitance (RC) combination that possesses a characteristic time constant.

Abstract: The invention comprises an apparatus for determining the contextual or physiological status of the individual wearing the apparatus. The apparatus is designed to be consumable or disposable. In most embodiments the invention comprises an adhesive housing. In some embodiments, two different sensors are secured to the housing. The apparatus is in electronic communication with a processing unit that can derive analytical status data by using the data received from the two sensors. In some embodiments, the processing unit is programmed to control other devices, or is programmed to trigger an event. In still other embodiments, the apparatus is in electronic communication with a separate computing device, which may contain the processing unit.

Abstract: The invention comprises an apparatus for determining the contextual or physiological status of the individual wearing the apparatus. The apparatus is designed to be consumable or disposable. In most embodiments the invention comprises an adhesive housing. In some embodiments, two different sensors are secured to the housing. The apparatus is in electronic communication with a processing unit that can derive analytical status data by using the data received from the two sensors. In some embodiments, the processing unit is programmed to to control other devices, or is programmed to trigger an event. In still other embodiments, the apparatus is in electronic communication with a separate computing device, which may contain the processing unit.

Abstract: A beat detection device includes: a pulse wave sensor adapted to detect and output a pulse wave signal; a body motion sensor adapted to detect and output a body motion signal due to a body motion of a human body; a pulse wave signal filtering section adapted to generate an adaptive filter based on the body motion signal to extract a noise signal in the pulse wave signal, and to output a beat signal obtained by eliminating the noise signal from the pulse wave signal; and a filter coefficient setting section adapted to set a coefficient of the adaptive filter to be a predetermined value in response to detection of increase in a body motion change beyond a predetermined threshold value based on the body motion signal.

Abstract: A system and device for measuring sexual function includes an adjustable ring forming an opening to receive a penis, at least one diagnostic sensor positioned on an inner surface of the adjustable ring, wherein the ring automatically couples the diagnostic sensor to the penis throughout a range of ring diameters, and a microcontroller in communication with the at least one diagnostic sensor. The at least one diagnostic sensor measures data during sexual activity and communicates the data to the microcontroller. In fact, in an example, the device is configured to be worn by a user during sexual activity.

Abstract: A wrist watch system is provided. The wrist watch system includes at least one sensor configured to detect biometric data of a user; and a watch communicatively coupled to the at least one sensor and configured to removably couple to a wrist of the user. The watch includes an output device configured to display data from the at least one sensor and a communication device configured to transmit, to an external source, data received from the at least one sensor.

Abstract: Described herein are technologies related to a wireless electronic vital sign monitoring of a person. More particularly, detecting vital signs and processing of the detected vital signs using a bio monitoring patch.

Abstract: An operator-controllable medical monitoring system including at least one medical sensor that is adapted to monitor at least one patient characteristic, a plurality of medical monitors, each including a monitor wireless transceiver and a medical information display and a patient companion assembly including a patient companion assembly wireless transceiver and a medical monitor selector wirelessly operative to initially select one of the plurality of medical monitors and to provide a monitor selection indication which is visually sensible to the operator.

Abstract: Arrhythmia may impact the determination of physiological information from a physiological signal. A patient monitoring system may detect the presence of arrhythmia based on changes in the physiological signal. Derived value data sets may be extracted from the physiological signal and calculations performed to generate arrhythmia features. The arrhythmia features may be used to generate an arrhythmia indicator that may indicate the presence of arrhythmia in the physiological signal.

Abstract: A system comprising implantable device, the implantable medical device including an intrinsic cardiac signal sensor, an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current, and a processor coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit. The processor is configured to initiate sampling of a transthoracic voltage signal in a specified time relation to a fiducial marker in a sensed intrinsic cardiac signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal, and determine lung respiration using the sampled transthoracic voltage signal.

Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject according to a schedule, under the control of a scheduling controller.

Abstract: The invention provides a body-worn monitor that measures a patient's vital signs (e.g. blood pressure, SpO2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g. resting, walking, convulsing, falling). The body-worn monitor processes this information to minimize corruption of the vital signs by motion-related artifacts. A software framework generates alarms/alerts based on threshold values that are either preset or determined in real time. The framework additionally includes a series of ‘heuristic’ rules that take the patient's activity state and motion into account, and process the vital signs accordingly. These rules, for example, indicate that a walking patient is likely breathing and has a regular heart rate, even if their motion-corrupted vital signs suggest otherwise.