Abstract: An electrosurgical apparatus having a feed structure comprising a radiofrequency (RF) channel for conveying RF electromagnetic (EM) radiation from an RF signal generator to a probe and a microwave channel for conveying microwave EM radiation from a microwave signal generator to the probe, wherein the RF channel and microwave channel comprise physically separate signal pathways, wherein the feed structure includes a combining circuit having an input connected to the signal pathway on the RF channel, another input connected to the signal pathway on the microwave channel, and an output connected to a common signal pathway for conveying the RE EM radiation and EM radiation separately or simultaneously to the probe, and wherein the microwave channel includes a waveguide isolator connected to isolate the signal pathway on the microwave channel from the RF EM radiation.

Abstract: An ultrasonic thrombus removing system includes a front sheath tube (1) and a rear sheath tube (5) that are independent and that are inserted into a blood vessel (2); a rear end outer portion of the front sheath tube (1) is mounted with a front blocking balloon (105), and a front end outer portion of the rear sheath tube (5) is mounted with a rear blocking balloon (504); a breaking cavity (4) being formed between the two blocking balloons; the front blocking balloon (105) and the rear blocking balloon (504) expand or contract in the blood vessel (2) by means of the squeezing or loosening of an external force so as to block or open front and rear sides of the thrombus (3); an inner portion of the rear sheath tube (5) is provided with a core tube (502) that co-axially penetrates therethrough, a front end of the core tube (502).

Abstract: A method for treating the kidney with focused extracorporeal shockwaves in a noninvasive manner. The method configured to restore blood flow velocity in the interlobular renal arteries, the method using non-invasive focused extracorporeal shockwave therapy (‘ESWT’), the method comprising applying between 1 and 2400 non-invasive focused shockwaves having a repetition rate above one shockwave per second, and energy density of about 0.02 to 0.18 mJ/mm2. The non-invasive shockwave treatment is applied to various focal zones encompassing renal structures.

Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.

Abstract: An ultrasonic surgical handpiece may include an assembled handpiece, an ultrasonic tip, a tubing set, and an irrigation sleeve. The assembled handpiece may include an assembled motor, a housing sleeve, and a nosecone. The housing sleeve and the nosecone may be disposed over a portion of the assembled motor. The assembled motor may include an assembled transducer, a transducer sleeve, and an angled adaptor. The transducer sleeve may be disposed over a portion of the assembled transducer. The assembled transducer may include an amplifier, one or more piezoelectric rings, and a connector block. A surgeon may use the ultrasonic surgical handpiece to perform a portion of a surgical procedure.

Abstract: To alleviate information-dependent behavior by using a mobile terminal of a user of the mobile terminal. A mobile terminal including a first signal generator that generates a frequency signal in the audible band, a second signal generator that generates a high-frequency signal in a frequency band higher than the audible band, a speaker that converts the high-frequency signal into a corresponding high-frequency sound, and a timing controller that controls timing of the generation of the high-frequency signal to be a timing that does not correlate with the timing of the generation of the frequency signal in the audible band is provided.

Abstract: A minimally invasive ultrasonic osteotome head and a minimally invasive ultrasonic powered system for bone; the minimally invasive ultrasonic osteotome head comprises an osteotome rod (11, 21, 31, 41, 51, 61) and a head end (12, 22, 32, 42, 52, 62), the head end (12, 22, 32, 42, 52, 62) being located at a front end of the osteotome rod(11, 21, 31, 41, 51, 61), and the head end (12, 22, 32, 42, 52, 62) being bent laterally at a certain angle, wherein knurled teeth or skewed teeth are provided on the bent portion. By means of bending the head end (12, 22, 32, 42, 52, 62), bone tissue around the transforaminal endoscope may be removed. Therefore, a surgeon may, as much as possible, have more operation space under the limited endoscope channel, thereby increasing bone removal efficiency.

Abstract: Temperature uncertainty maps are calculated based on a rolling window of temperature maps, which is updated as new temperature maps are generated. The rolling window mitigates the effect of transient motion during a thermal therapy procedure. A clinician or an automated control system can then update a portion of an anatomical boundary or the thermal therapy applicator center based on the temperature uncertainty map.

Abstract: A treatment method to reduce or eliminate a patient's symptoms caused by a medical condition or disease is disclosed. The treatment has the step of administering acoustic shock waves directed to one or more reflexology zones or to one or more reflexology zones and an area near a source of the pain if any is exhibited to treat the medical condition. The treatment further has the steps of activating acoustic shock waves of an acoustic shock wave generator to emit acoustic shock waves and subjecting the one or more reflexology zones or the one or more reflexology zones and the area near a source of the medical condition or pain, if any is exhibited, to acoustic shock waves to treat the medical condition.

Abstract: Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.

Abstract: A surgical procedure of preparing bone holes to dispose an implanted tendon to a femur when performing reconstruction of a ligament in a knee joint, includes: forming a first bone hole in the femur; and applying ultrasonic vibration from a treatment portion of an ultrasonic treatment instrument to the femur, thereby cutting and expanding the first bone hole from the inside of the knee joint to the first bone hole of the femur along a predetermined depth, and forming a second bone hole having a polygonal shape, an approximately polygonal shape, an elliptical shape or an approximately elliptical shape to receive the implanted tendon.

Abstract: The present disclosure relates to an ultrasound therapy device using high-intensity focused ultrasound (HIFU) and a control method thereof. The ultrasound therapy device comprises: an array type HIFU converter having a plurality of HIFU conversion elements; and a control unit for performing a control to treat tissues in a focusing area by selecting and driving some of the HIFU conversion elements of the array type HIFU converter and irradiating ultrasound signals to an object through the driven active conversion elements to generate heat energy, wherein, after an elapse of a predetermined time period, the control unit drives a combination of other conversion elements as new active conversion elements in replacement of the active conversion elements.

Abstract: A non-invasive system for monitoring brain trauma, the system comprising: a plurality of spaced apart brainwave sensors configured to monitor brainwaves of a user of the system; one or more force determination sensors, configured to determine an amount of force exerted on the user's head; and a processing unit configured to: obtain a plurality of brainwave readings from the brainwave sensors and a plurality of force readings from the force determination sensors; provide a notification upon the force readings indicating that the amount of force exerted on the user's head exceeds a threshold or upon the brainwave readings indicating an abnormal brain activity.

Abstract: Surgical instruments include a first drive assembly having a first drive gear and a lockout mechanism positioned for releasable engagement with the first drive assembly to inhibit rotation of the first drive gear. The lockout mechanism includes a pawl and an actuator for moving the pawl from a first position in engagement with the first drive gear to a second position spaced from the first drive gear.

Abstract: A method of modulating glandular secretions by administering acoustic shock waves to a reflexology zone has been discovered. In one preferred embodiment, a treatment method achieves one or more of a) modulating blood sugar levels, b) stimulating insulin production levels or c) normalizing A1C levels by administering acoustic shock waves to a reflexology zone or region of a patient. The treatment method further has the steps of: activating acoustic shock waves of an acoustic shock wave generator to emit acoustic shock waves; subjecting the reflexology zone to acoustic shock waves stimulating the pancreas to have a modulated response wherein the modulated response is one of an adjustment in blood sugar levels or insulin production and release or normalizing A1C levels which increases low level output, decreases high level output or stabilizes erratic output; and wherein the emitted acoustic shock waves are focused or unfocused.

Abstract: Disclosed is an ultrasonic probe having an improved heat radiation capability. The ultrasonic probe includes a transducer module configured to transmit and receive an ultrasonic signal, a housing configured to accommodate the transducer module, a cable connected to the transducer module inside the housing and drawn from the inside of the housing to the outside of the housing through an end of the housing, a bending device configured to cover the cable and connected to the end of the housing to receive heat, a strain relief configured to surround the bending device and including a heat radiation groove extending along a circumferential direction of the cable, and a heat radiation fin inserted into the heat radiation groove such that one end thereof is in contact with the bending device and the other end thereof is in contact with outside air.

Abstract: A shock wave generating device includes an optical fiber and a reflective part, and is configured to reflect and converge the shock wave generated inside the reflective part to an outside of the reflective part. The reflective part includes: a reflector having a concave surface having a cut surface-of-revolution shape, and a through hole, which is formed coaxially with a rotating axis of the concave surface, and into which the optical fiber is to be inserted; a sealing body configured to seal an opening portion of the concave surface; and a liquid to be charged between the concave surface and the sealing body. The optical fiber has a distal end arranged at a position on a rear side of a focal point of the concave surface, at which the shock wave reflected by the concave surface is convergeable outside the reflective part.

Abstract: A convertible patient support apparatus includes a patient support bed and a removable patient contact disposed in a hole in the patient support bed. The hole is defined by a support frame. A static membrane is attached to the support frame. One of a plurality of removable patient contacts can be removably attached to the support frame to convert the convertible patient support apparatus based on the patient and/or therapy.

Abstract: Systems and methods for noninvasive tissue tightening are disclosed. Thermal treatment of tissues such as superficial muscular aponeurosis system (SMAS) tissue, muscle, adipose tissue, dermal tissue, and combinations thereof are described. In one aspect, a system is configured for treating tissue through delivery of ultrasound energy at a depth, distribution, temperature, and energy level to achieve a desired cosmetic effect.

Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.

Abstract: In one example embodiment, a system for treating a tissue site is disclosed that may comprise a manifold including a non-porous film having a plurality of closed cells defined by a sealed region perforated with apertures extending through the sealed region, wherein the manifold is adapted to contact the tissue site. The system may further comprise a cover adapted to provide a fluid seal between a therapeutic environment including the manifold proximate one side of the cover and a local external environment on the other side of the cover. In one embodiment, the plurality of closed cells is adapted to form distal channels with the cover and the apertures are adapted to provide fluid communication between the distal channels and the tissue site. The system may further comprise a negative-pressure source fluidly coupled to the therapeutic environment and adapted to provide negative pressure through the distal channels and the apertures to the tissue site.

Abstract: Systems and methods for ablating tissue include an ablation device having an energy source and a sensor. The energy source provides a beam of energy directable to target tissue, and the sensor senses energy reflected back from the target tissue. The sensor collects various information from the target tissue in order to facilitate adjustment of ablation operating parameters, such as changing power or position of the energy beam. Gap distance between the energy source and target tissue, energy beam incident angle, tissue motion, tissue type, lesion depth, etc. are examples of some of the information that may be collected during the ablation process and used to help control ablation of the tissue.

Abstract: An implant sized and shaped to be endovascularly delivered to the middle meningeal artery includes a carrier that carries a payload between first and second ends thereof. An anchor mechanism associated with the implant transitions into a swollen state in response to exposure to bodily fluids. In the swollen state, said anchor mechanism anchors the implant to the middle meningeal artery. Before or during the transition, the anchor mechanism permits endovascular delivery of the implant to the middle meningeal artery.

Abstract: Disclosed are methods and devices for treatment of subcutaneous fat by simultaneously transdermally inducing both ultrasonic transverse vibrations and ultrasonic longitudinal vibrations in subcutaneous tissue, for example for reduction of subcutaneous fat.

Abstract: An external ultrasound generating treating device (12) to induce spinal cord and/or spinal nerve treatment comprises at least two sub-arrays of ultrasound generating treatment transducers, a left sub-array (20iL) being located on a left lateral side and a right sub-array (20iR) being located on a right lateral side of the central longitudinal axis (Ai). The device comprises a support structure (32) having at least one module (34i) comprising a left lateral section (34iL) and a right lateral section (34iR). The support structure (32) maintains, in use of the device, a constant distance and a constant relative angular orientation around the central longitudinal axis (Ai) between the first left and first right treatment transducers or set of treatment transducers (20iL, 20iR). Also disclosed is an apparatus including the external ultrasound generating treating device (12) and methods of its use.

Abstract: A sensor system includes an actuator, an accelerometer coupled with the actuator, a rigid member, a transducer, and one or more processors. The actuator generates motion. The accelerometer outputs an acceleration signal responsive to at least the motion of the actuator. The rigid member extends from a first end coupled with the accelerometer to a second end. The transducer is coupled with the second end of the rigid member. The transducer can be configured to couple with a load, and can output a force signal responsive to at least a portion of the motion of the actuator transmitted to the transducer via the rigid member. The one or more processors determine a mechanical impedance of the load based at least on the acceleration signal and the force signal.

Abstract: Disclosed is a method and apparatus for more locally stimulating a desired stimulation region in a predetermined part of an object, the apparatus including a first ultrasonic wave generator configured to output a first ultrasonic beam to a predetermined part of an object, a second ultrasonic wave generator configured to output a second ultrasonic beam to the predetermined part of the object, and a controller configured to control the first ultrasonic wave generator and the second ultrasonic wave generator such that central axes of the first ultrasonic wave generator and the second ultrasonic wave generator are disposed on the same plane, and a crossing angle between the first ultrasonic beam and the second ultrasonic beam is a predetermined angle.

Abstract: Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuant to various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex (mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC.

Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Abstract: The present invention provides an asymmetric EEG-based coding and decoding methods for BCIs, the BCI system includes an evoked stimulus module, an acquisition module and an EEG signal data set including a training set Xk and a testing sample Y, and an EEG signal decoding module; the evoked stimulus module sends a hybrid coding visual stimulus to subjects to evoke a specific EEG signal as required; the acquisition module obtains data information by amplifying and filtering the EEG signal so as to constitute EEG signal module; the decoding module coverts the data information into an instruction set for outputting the coding method of the present invention uses asymmetric characteristics of brain electrophysiological activity response to stimulus, combines with coding strategies such as SDMA, CDMA, FDMA and phase division multiple access coding.

Abstract: A surgical instrument includes: a handpiece; a movable member configured to transmit a driving force to a treating member to treat a subject by moving relatively to the handpiece; and a connector arranged inside the handpiece, and including a strip to apply a pressing force to the movable member. The movable member includes a first conductive portion formed therein. The connector includes a second conductive portion formed on the strip. The second conductive portion abutting against the first conductive portion to connect the movable member and the handpiece electrically. The second conductive portion of the connector is a molded interconnect device constituting a three-dimensional circuit.

Abstract: A multistatic array topology and image reconstruction process for fast 3D near field microwave imaging are presented. Together, the techniques allow for hardware efficient realization of an electrically large aperture and video-rate image reconstruction. The array topology samples the scene on a regular grid of phase centers, using a tiling of multistatic arrays. Following a multistatic-to-monostatic correction, the sampled data can then be processed with the well-known and highly efficient monostatic Fast Fourier Transform (FFT) imaging algorithm. In this work, the approach is described and validated experimentally with the formation of high quality microwave images. The scheme is more than two orders of magnitude more computationally efficient than the backprojection method. In fact, it is so efficient that a cluster of four commercial off-the-shelf (COTS) graphical processing units (GPUs) can render a 3D image of a human-sized scene in 0.048-0.101 seconds.

Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.

Abstract: The purpose of the present invention is to propose a device for detecting refrigerant leaks in a refrigeration cycle. The device can be applied irrespective of whether a liquid-receiving tank is present, has a simple configuration, and can be installed easily and inexpensively as a retrofit. Moreover, the device is configured so as to detect the presence of leaks without stopping operation of the equipment, and is innovative and of exceptional utility such that there is no decrease in the equipment operation rate as caused by detection of leaks.

Abstract: A dual-modality photoacoustic remote sensing combined with optical coherence tomography (PARS-OCT) system for visualizing details in a sample, the system comprising one or more light sources configured to generate (1) one or more excitation beams configured to generate signals in the sample at one or more first locations below a surface of the sample; (2) one or more interrogation beams incident on the sample at one or more second locations; (3) a sample beam; and (4) a reference beam.

Abstract: Embodiments provide an ultrasound treatment system and method. In some embodiments, the system includes a removable transducer module having an ultrasound transducer. In some embodiments, the system can include a hand wand with at least one finger activated controller and a control module that is coupled to the hand wand and has a graphical user interface for controlling the removable transducer module, and an interface coupling the hand wand to the control module. The interface may provide power to the hand wand or may transfer a signal from the hand wand to the control module. In some embodiments, the treatment system may be used in cosmetic procedures on at least a portion of a face, head, neck, and/or other part of a patient.

Abstract: A surgical instrument has a first modular assembly and a second modular assembly. The first modular assembly has a body, an ultrasonic waveguide, an ultrasonic blade connected to a distal end of the ultrasonic waveguide, and a coupling member that movably couples with the body. The second modular assembly has a clamp arm assembly with a first pivot coupling, a clamp pad assembly with a second pivot coupling, and a distal outer sheath that selectively couples to the body of the first modular assembly via the coupling member. The distal outer sheath has an interior surface that houses a portion of the ultrasonic waveguide, and this interior surface also houses the first pivot coupling and the second pivot coupling.

Abstract: A device for the prevention of stroke is provided that has a processor, a compression system, a compression member, and a vascular probe carried by the compression member. The vascular probe senses a parameter of a circulation system from a closed neck artery that is not being externally accessed. The processor processes the closed parameter and based upon this processing communicates with the compression system to instruct the compression system to actuate the compression member. The compression member and vascular probe are external to the interior of the patient when the vascular probe senses the closed parameter of the circulation system.

Abstract: A robotic surgical system comprising a surgical instrument comprising an end effector comprising (i) a blade, (ii) a first jaw member including a first electrode, and (iii) a second jaw member including a second electrode. The robotic surgical system may also comprise a motor and a control circuit configured to: (i) produce control signals comprising a first control signal and a second control signal, (ii) deliver an electrosurgical energy signal to the first electrode and the second electrode via the first control signal, (iii) deliver a drive signal to the motor via the second control signal (iv) receive at least one feedback signal, (v) determine a rate of change based on a first feedback signal of the at least one feedback signal, and (vi) maintain the rate of change at a predetermined rate or within a predetermined range.

Abstract: A bio-signal acquiring apparatus includes a sensor part and a signal processor. The sensor part includes a bio-signal sensor, a load sensor, and an ultrasonic sensor array, the bio-signal sensor configured to detect a bio-signal of an object that comes into contact with the sensor part, the load sensor configured to detect a contact load of the object, and the ultrasonic sensor array configured to detect contact load distribution of the object. The signal processor is configured to obtain a contact load of the object at a region of interest based on the contact load and the contact load distribution, and configured to output the contact load of the object at the region of interest and the bio-signal.

Abstract: A flexible device having a layered structure for delivering electrical stimulation and one or both of light and ultrasound to a skin surface is provided. The device is flexible so as to form a non-planar contact surface against the skin surface, and includes one or both of (a) a flexible light emitter layer positioned between two flexible conductive layers that emits light when driven by a power source and (b) a flexible ultrasound emitter layer positioned between two flexible conductive layers that produces ultrasound when driven by a power source. The device also includes a flexible electrical stimulation layer that functions as an electrode and is configured to provide electrical stimulation when driven by a power source.

Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.

Abstract: A multi-lumen catheter with a connectable hub for monitoring intra-abdominal pressure including an expandable outer balloon and a first lumen communicating with the balloon. The balloon and first lumen are filled with gas to form a gas filled chamber to monitor pressure within the bladder to thereby monitor pressure within an abdomen of the patient. A second lumen communicates with the bladder to remove fluid from the bladder. The hub includes a pressure transducer for measuring bladder pressure based on gas compression and has an elongated member insertable into the first lumen to advance gas through first lumen to expand the balloon.

Abstract: A medical device is described having a handle, a shaft coupled to the handle, an end effector coupled to the shaft and an ultrasonic transducer coupled to the end effector for delivering ultrasonic energy to tissue or a vessel to be treated. A drive circuit is provided for generating a drive signal that is applied to the ultrasonic transducer. In one embodiment, the drive circuit includes a resonant circuit and a controller that varies the period of the drive signal passed through the resonant circuit in order to control the power supplied to the ultrasonic transducer.

Abstract: Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.

Abstract: In a method for detection of defective ultrasonic transducers in an in ultrasonic sensing device, an ultrasonic signal is generated at an ultrasonic sensing device comprising a plurality of ultrasonic transducers. A reflected ultrasonic signal corresponding to the ultrasonic signal is received at at least one ultrasonic transducer of the plurality of ultrasonic transducers. It is determined whether performance the at least one ultrasonic transducer is degraded based at least in part on the reflected ultrasonic signal.

Abstract: Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.

Abstract: A generator is configured to output two or more waveforms at different frequencies. In particular, the generator is configured to provide an ultrasonic waveform, which may be suitable for driving a transducer of an ultrasonic surgical instrument, and electrosurgical radiofrequency energy, which may be suitable for electrosurgical instruments.

Abstract: The present invention generally relates to devices for imaging the interior of a vessel. The device can involve an elongated body configured to fit within the lumen of a vessel, a rotatable shaft positioned inside the elongated body, and a telescoping element, wherein a portion of the elongated body extends through the telescoping element, in which the elongated body is configured to contain the rotatable shaft inside the telescoping element.

Abstract: The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.