Abstract: The invention relates to a wound dressing and methods of preparation and use thereof for promoting healing of a wound bed. In particular, the wound dressing is advantageous for application to a debrided wound bed. The wound dressing comprises an open conduit polymeric foam matrix, and a hydrophilic polymer which is disposed in dry form on the inner surfaces of the conduits within the matrix.

Abstract: Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.

Abstract: A bandage system is provided that is capable of being held by an upstanding snap member attached to a wound site. The bandage system has a snap engaging member for coupling to the snap member. A cushion member is provided that has a wound engaging surface for overlaying the wound site. A pressure exerting base member is coupled to the base member for urging the cushion member into engagement with the wound site.

Abstract: A method of providing moisture therapy to a subject by applying a moist therapy compress against a treated body portion. The moist therapy compress includes a fluid-permeable shell, a flexible backing fastened to the shell to define an enclosure, and silver-retaining hydrophilic zeolite fill granules loosely contained within the enclosure. The therapy compress is exposed to a source of moisture to cause absorption of water into the silver-retaining hydrophilic zeolite, and the moisture is delivered from the silver-retaining hydrophilic zeolite through the fluid permeable shell to the treated body portion.

Abstract: A wound dressing includes a wound-filling member attached to a hemostasis inducer that can be impregnated with an active compound, such as coagulants. The wound dressing can be placed in wounds to provide pressure, as well as chemical action, to promote blood coagulation and thereby arrest bleeding. A wrap can be attached to the wound dressing to provide an easy and quick method of securing the wound dressing. The wound dressing can be compressed in a small package for easy transport.

Abstract: An antimicrobial material suitable for use in a compressive bandage is provided. Also, a composition that is used to produce this material and the methods for production are provided.

Abstract: The present invention provides a wound dressing that includes a patterned gradient of immobilized growth factor molecules that promote directed migration of cells during dermal wound healing. Growth factor is immobilized on a support substrate to present a gradient pattern of increasing growth factor concentration to migrating cells. Methods of promoting wound healing using the patterned gradient wound dressing and fabrication methods of same are also provided.

Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of treating a wound comprises the steps of providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.

Abstract: Devices and methods are disclosed for achieving hemostasis in traumatized patients. Such haemostatic packing devices and methods are especially useful in the emergency, trauma surgery or military setting. In such cases, the patient may have received trauma to abdominal viscera, the thoracic cavity or the periphery. The devices utilize fluid impermeable outer surfaces and distributed pressure to achieve tamponade and hemostasis, primarily by exertion of pressure. The devices come in a variety of configurations including sheet, rolled sheet, folded sheet and polygonal solids including extruded shapes. The devices are capable of serving as carriers for thrombogenic or antipathogenic agents. The devices are flexible, bendable, and conformable in their wet or dry state so that they exert distributed pressure on the wound. Peripheral haemostatic packing devices include optional adhesive hemostatic barriers to cover the entire wound area over the hemostatic pack.

Abstract: This disclosure relates to a compression dressing designed to provide moisture transport properties to a contact surface and compression therapy for patients with swelling due to various medical conditions. The compression dressing is minimally comprised of at least one layer of moisture transport fabric comprised of elastic fiber that exhibits a sufficient amount of elasticity to apply a compressive force to a body part when applied thereto. The compression dressing further provides one-way, active fluid management which can move fluid away from the skin. The compression dressing may also include at least one absorptive reservoir layer that is applied to the outer surface of the moisture transport fabric. This absorptive reservoir layer may be removed as needed without substantially disrupting the compressive force applied to a body part. The method for using the compression dressing to manage fluid movement and edema is also provided.

Abstract: A disposable bandage for covering a wound area of a skin surface includes a self adhesive first fastener portion and a second fastener portion, a dome having a generally rectilinear shape and constructed from a thin rigid material, the dome being coupled to the first fastener portion along one edge and coupled to the second fastener portion along a second edge. The dome includes pleats that extend across the dome shape from the top edge to the bottom edge of the dome. A gasket is formed of a stretchable material and extends around the underside of the dome. The gasket is held in contact with the skin surface when the first fastener portion and the second fastener portion are pressed to a user's skin and, when the first fastener portion and the second fastener portion are moved away from each other, the pleats are unfolded and the gasket material is stretched and remains in contact with the skin surface.

Abstract: The present invention relates to an application system for an active ingredient release system, comprising a film-form application strip, which is in each case bonded detachably to an active ingredient-containing plaster and a separate active ingredient release regulator separate there from.

Abstract: A protective device having a substantially rigid casing for placement on a patient's skin, wherein the casing has a hollow interior facing the patient's skin and a lip. The casing can be spanned across its hollow interior by a membrane. The casing can have a first adhesive seal attached to a bottom surface of the lip of the casing, and a second adhesive seal attached to the top surface of the lip of the casing.

Abstract: A tracheostomy dressing (1) which comprises an integral wound locating device (4) for locating and applying pressure to a healing tracheostomy wound.

Abstract: The invention relates to a medical bandage, which comprises at least two transdermal patches, and wherein said at least two transdermal patches each comprise a pain-relieving pharmaceutically active substance such as an NSAID.

Abstract: A wound care dressing comprising one or more nonwoven blankets, where each nonwoven blanket comprises a plurality of fibers, where each of the plurality of fibers are formed from one or more saccharides in optional combination with one or more medicaments.

Abstract: Described is a method of supplying an active ingredient to a location beneath the outer layer of skin or into soft tissue which includes the steps of providing a polymer-containing liquid comprising an active ingredient; subjecting the liquid issuing from an outlet to an electric field to cause the liquid to form at least one electrically charged jet that breaks up to provide charged fiber fragments or fibrils containing an active ingredient, the fiber fragments or fibrils being capable of sticking onto the outer layer of skin or soft tissue to supply the active ingredient beneath the outer layer of skin or soft tissue; and contacting skin with the fiber fragments or fibrils.

Abstract: An adhesive hydrogel dressing as well as methods of applying the dressing to a patient. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. A release element is in contact with at least a portion of the edge of the hydrogel pad proximate the area that the hydrogel pad and release liner separate during liner removal.

Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

Abstract: The present invention provides a multilayer bandage, having a webbing for contacting a wound and a first membrane that has at least one water-insoluble polymer and is water-impervious. The present invention further provides methods for making the multilayer bandage, methods of using the multilayer bandage for accelerated wound healing, and kits having compositions of the present invention.

Abstract: The present invention relates to a process for the production of an absorbing sanitary article comprising lactic acid producing bacteria. The process comprises dispersion of lactic acid producing bacteria in a carrier, and application of the resulting dispersion of bacteria by continuous or discontinuous gentle feeding on and/or in at least one component that are to form part of the final article. Furthermore, the present invention relates to an absorbing sanitary article comprising lactic acid producing bacteria dispersed in an essentially hydrophobic carrier. The dispersion of bacteria forms at least one continuous or discontinuous string on and/or in the final sanitary article.

Abstract: Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.

Abstract: A bandage system capable of being held to an upstanding post attached to a wound site is disclosed. The bandage system includes a flexible retainer portion and a cushion portion. The flexible retainer portion includes at least one aperture through which the upstanding post can be inserted for maintaining the bandage system in a position adjacent to the wound site.

Abstract: Processes for preparing polyurethane hydrogels which include free-radically cross-linking: A) hydrophilic polyurethanes having one or more olefinically unsaturated groups selected from the group consisting of acrylate and methacrylate groups; in the presence of B) water; and C) a redox system including a water-soluble oxidizing agent and a water-soluble reducing agent, the oxidizing agent being capable in terms of redox potential of reacting with the water-soluble reducing agent by free-radical formation, wherein the hydrophilic polyurethanes are based on hydroxyl-functional polyalkylene oxides.

Abstract: A wound dressing applicator (10) for applying hydrocolloid dressings, compositions for tissue regeneration and the like to a patient's skin. Known wound dressing applicators do not effectively protect against contamination of the wound dressing and/or can be fiddly and difficult to operate and be rendered unusable by unwanted premature separation of the various layers of material adhered to one another. The present applicator comprises a rigid body (20) having a rigid body enclosure (30) for receiving a wound dressing, and an ejector (40) for ejecting the wound dressing from the rigid body enclosure and onto a patient's wound. This enables effective and aseptic handling of a wound dressing and application of the wound dressing onto a patient's wound.

Abstract: An adhesive device used as a wound dressing, ingredient delivery device or IV hold-down in which inadvertent edge release of these devices along the periphery of the polymeric film layer is minimized when the handling layer, which is adhered to the polymeric film layer, is removed after application of the polymeric film layer to the patient.

Abstract: Devices and methods are disclosed for achieving hemostasis in patients who have received skin-penetrating wounds to the periphery, including the head, arms, and legs. Such haemostatic packing devices and methods are especially useful in the emergency, trauma surgery, or military setting. The devices utilize fluid impermeable barriers surrounded by exterior dams and pressure to achieve tamponade and hemostasis, primarily by exertion of force to hold the dams against the skin surrounding a wound. The devices are capable of serving as carriers for thrombogenic, antimicrobial or antipathogenic agents. The devices do not require the use of adhesives to work as they are attached to the patient using mechanical locking devices. Peripheral haemostatic packing devices include optional adhesive hemostatic barriers to attach at least a portion of the device to the skin or to assist with initial coupling of a hold-down strap to another strap using a more secure mechanical lock.

Abstract: For application of active substances to a wound surface a porous padding (12) is provided upon the wound (10), which is sealingly covered over with a foil (14). A fluid active substance is introduced into the padding (12) via a supply line (22) and is then suctioned out of the padding (12) via a removal line (26). Closure mechanisms (32, 34) control the introduction of the active substance and the suctioning off of the active substance in the manner, that the active substance after being introduced remains for a predetermined dwell time in the padding (12), before it is suctioned off. After the suctioning off the vacuum in the padding (12) is maintained for a certain time period, before renewed introduction of the active substance. The opening of the closure mechanisms (32, 34) are temporally controlled to occur slowly.

Abstract: The invention provide a topical adhesive patch having a flexible backing having a front side and a back side; a first formulation positioned on at least a portion on the front side of the backing, in at least a portion on the front side of the backing, or on and in at least a portion on the front side of the backing; a second formulation positioned on at least a portion on the back side of the backing, in at least a portion on the back side of the backing, or on and in at least a portion on the back side of the backing; the first formulation comprises an adhesive; and the second formulation comprising an antibiotic agent, anti-fungal agent, anti-viral agent, or combination thereof, and uses therefor.

Abstract: A cushioning device for use on skin, such as on a finger or foot, comprising a cushioning layer having a skin side and an outer side and an ultra-hydrophilic pressure-sensitive adhesive layer coupled to the skin side of the cushioning layer.

Abstract: A pad for the treatment of inflammatory afflictions, which comprise an absorbing matrix, a medicament that is a hypertonic substance such as inorganic salt solutions, and a functional backing for directing and limiting the activity of the medicament to the desired body surface. The pad may further comprise binding means for maintaining it in place and in engagement with the desired body surface. The absorbing matrix and the functional backing may be structurally connected or separate. The absorbing matrix may be made of cotton, lignin cellulose or synthetic absorbing materials.

Abstract: A non-contact wound covering for covering a wound includes a peripheral sealing ring. The peripheral sealing ring is covered by a barrier layer and this assembly is attached to the skin with an adhesive. The barrier layer and peripheral sealing ring together define a treatment volume over the wound. Treatment fluid is introduced into the treatment volume through an inlet, and is exhausted therefrom through an outlet or an exhaust filter.

Abstract: The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer.

Abstract: Fibrous antimicrobial materials for use in structures and barrier applications, such as face masks and wound dressings, have been developed from antimicrobial polymeric materials. The fibrous antimicrobial materials also are particularly suitable for use in air and water filtration. The antimicrobial polymeric materials are prepared from solid solutions of antimicrobial bisguanide compounds blended with certain thermoplastic polymers. The antimicrobial polymeric materials may be extruded into fibers or used in the particulate form for preparation of the nonwoven antimicrobial materials. The antimicrobial bisguanide compound, such as chlorhexidine, are distributed at the molecular level within at least one thermoplastic polymer, such as a polyolefin in which the antimicrobial bisguanide compound is soluble, to form a miscible blend. Methods for their formation and use also are provided.

Abstract: A method and system for producing an improved dressing product, useful for covering/protecting a moist wound is disclosed. The dressing product comprising fibers of a spinnable polymer forming a twisted ribbon. By virtue of this twisting, the fibers, in particular at the periphery of the ribbon, are connected to one another so as to afford better mechanical cohesion and a smoother outer appearance, without affecting the action of absorption, dilation and gel formation for extracting the biological fluid, nor the action of retention of proteins and other cellular and bacterial waste matter which would impede the phenomenon of cicatrization. The ribbon twisting equipment comprises a conical bowl (1) for driving fibers in rotation with a twisting die (3) in its narrowed downstream part (2), and a gear mechanism (4) for driving in rotation.

Abstract: The invention relates to a kit comprising the following individual components: (a) polymers comprising at least one free amino group, (b) bridge molecules selected from the group consisting of monocyclic ortho-dihydroxyaromates, mono-cyclic para-dihydroxyaromates, bicyclic monohydrxyaromates, polycyclic monohydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof, and (c) polyphenoloxidases, in particular, lignolytic polyphenoloxidases, whereby the individual components b) and c) are not in contact.

Abstract: Chlorine and Hydrogen Peroxide Medical Therapies including Ear Dropper Multiple Vile Medicine Mixing Cool Mist Vaporizer with detachable Inhalation Hose and Facemask Double Density Air Filter, 3-Speed Motor with On/Off Switch, Home and Hospital Models with Atomizer and an Orifice for attachment to and Oxygen Tank, Pre-Wrapped Bandages, Gauze Stick-On Strips or Squares or Strip-less Gauze Pads with Liquid or Gel, Chlorine or Hydrogen Peroxide also, Lotions for Skin Infections and Cancers, Chemical Injections and Patient Baths, and Wellness Therapies

Abstract: A wound management fibre comprising a base fibre having a chitosan material associated therewith, characterised in that the wound management fibre has a significant proportion of chitosan associated therewith.

Abstract: A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to placed over the wound. Illustratively, the bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.

Abstract: A wound dressing including an absorbent core defining opposed proximal and distal surfaces, the distal surface of the absorbent core defining a central portion, a border portion and an intermediate portion interposed between the central and border portions. The backing layer defines at least one compliant element disassociated from the distal surface of the absorbent core and including at least one ridge extending outwardly relative to the distal surface of the absorbent core.

Abstract: A method of treating a wound using a customized dressing. In the method, at least one wound characteristic is evaluated. A treatment need as a function of the at least one wound characteristic is determined. A dressing having a dressing characteristic responsive to the treatment need is fabricated and applied to the wound. A dressing for use therewith and an apparatus and system for fabricating the dressing are provided.

Abstract: A dressing having a flexible sleeve shaped to accommodate a substantially cylindrical body portion, the sleeve having a lining which is substantially non-adherent to the body part being bandaged and having a peripheral securement means which attaches two peripheral portions to each other without those portions being circumferentially adhered to the sleeve portion.

Abstract: A wound covering is described herein and which includes a flexible substrate having first and second portions which are affixed together, and moveable one relative to the other, and wherein the second portion is, at least in part, optically transparent, and permits the viewing of a wound site on a patient; and an at least partially rigid member mounted on the first portion, and extends outwardly relative to the first portion.

Abstract: The invention relates to dressings comprising a particle mixture of polyacrylate particles for using in modern wound treatment. The invention especially relates to a dressing comprising a particle mixture of polyacrylate particles, which contains a particle fraction for inhibiting proteases in a wound and a particle fraction for absorbing or eliminating aqueous liquids.

Abstract: Dental dressing assemblies are formed from hydrophilic polymer sponge structures, such as a densified chitosan biomaterial.

Abstract: A composition is formed by the step of feeding a molecule that has an active oxygen-forming species into a silicone based polymer. The silicone-based polymer is substantially free of pendant groups that are reactive with active oxygen species. Silicone-based polymers have proven scar-healing properties. As such, the composition is useful for treating skin disorders, especially scars, to reduce the appearance of the scars. Furthermore, bacteria and infections may contribute to the formation of scars. The active oxygen-forming species form active oxygen species, which oxidize pathogens including bacteria, viruses, and fungus to sterilize an area in contact with the composition. As a result, the appearance of scars treated with the composition may be even further reduced due to the presence of the molecule having the active oxygen-forming species.

Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of treating a wound comprises the steps of providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.

Abstract: Provided is a patch containing a drug, a metal salt, an adsorbent and a pressure-sensitive adhesive base, where the metal salt is a salt containing a substance capable of forming a drug salt by bonding to the drug or a component thereof, a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed, and the adsorbent is an adsorbent that adsorbs a polar solvent contained in the patch.

Abstract: Described are cotton fibres, yarns and fabrics functionalized with aminoglycoside antibiotics and a gelatin, for the production of bandaging for skin wounds and lesions which, by allowing a lengthy period of protection from infection risk, require less frequent changing than traditional bandages, and enable a better and faster healing of the wounds or lesions.

Abstract: The present invention is directed to the use of honey in medical dressings. Preferred embodiments modify honey with a viscosity increasing agent, resulting in a range of possible compositions including ointments and salves, self-adhesive gels such as for use on mouth ulcers and pustules, and pliable or flexible sheets which can be used as a wound covering. Preferred viscosity increasing agents include both particulate and continuous gels, respective examples of each including agars and alginates. Selected honeys preferably, but not necessarily, exhibit antibacterial properties other than what is merely conferred by osmolarity and sugar concentration effects.