Delivering Fluid Or Material Through Wall Of Inflated Means Patents (Class 604/103.01)
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Publication number: 20090018524Abstract: An expandable drug delivery device that can be implanted or otherwise delivered in and/or adjacent to a bone and/or soft tissue (e.g., connective tissue) for orthopedic applications is disclosed. Devices and methods are described herein for delivering agents for orthopedic and other uses. In particular such devices and methods can be useful for delivering agents to heal damaged tissue or prior to more invasive and traumatic orthopedic procedures.Type: ApplicationFiled: June 13, 2008Publication date: January 15, 2009Applicant: Stout Medical Group, L.P.Inventors: E. Skott GREENHALGH, John-Paul ROMANO
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Publication number: 20090012468Abstract: The present invention provides for a local drug delivery mechanism for use with a protection device. An infusing device is used to charge the drug into the catheter lumen toward a distal portion of the lumen having a plurality of drug delivery exit ports. The drug exits the ports into the patient's vascular system and is able to flow toward a filter maintaining the patency of the filter.Type: ApplicationFiled: September 18, 2008Publication date: January 8, 2009Inventors: Kent D. Anderson, Jennifer L. Pavlovic, Sivaprasad Sukavaneshvar
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Patent number: 7473242Abstract: Method and systems for treating a vulnerable plaque associated with a blood vessel of a patient are disclosed. The method includes positioning an endoluminal device within a lumen of the blood vessel. An expandable member of the endoluminal device is expanded adjacent a wall of the blood vessel. A blood vessel coating substance is administered from the expanded expandable member. The administered blood vessel coating substance adheres to the wall of the blood vessel. A first system includes an endoluminal device including at least one aperture formed therein. An expandable member is operably attached to the endoluminal device. The expandable member comprises an outer surface including at least one groove disposed thereon. The expandable member is expanded within the blood vessel and a blood vessel coating substance is administered through the aperture and onto the expandable member outer surface.Type: GrantFiled: April 29, 2004Date of Patent: January 6, 2009Assignee: Medtronic Vascular, Inc.Inventors: Maura G. Donovan, Alexander J. Karnauskas
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Publication number: 20090005733Abstract: Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.Type: ApplicationFiled: October 24, 2007Publication date: January 1, 2009Inventors: Jessica G. Chiu, Gregory Waimong Chan, Gabriel Asongwe, Robert C. Esselstein, Douglas Gesswein, Srinivasan Sridharan, Nianjiong Joan Bei, William E. Webler, Stephen G. Schaible, Mina Chow, Yan Shen, Hongzhi Bai, Mark J. Bly, Thomas R. Hatten
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Publication number: 20090005849Abstract: A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.Type: ApplicationFiled: March 21, 2007Publication date: January 1, 2009Inventors: Syed Faiyaz Ahmed Hossainy, Mikael Trollsas, Thierry Glauser, Yiwen Eveleen Tang, Eugene T. Michal
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Publication number: 20080319415Abstract: A balloon-angioplasty device for dilating a. region of a vessel of a patient which has been at least partially occluded by the presence of a stenotic lesion in the vessel is disclosed. The device comprises an elongate catheter shaft having an inflatable element located around the catheter shaft proximal to its distal end, the inflatable element comprising a dilatation balloon and a membrane which extends in a longitudinal direction around the dilatation balloon and has at least one flushing fluid opening located at or near its distal end. At least a portion of the flushing fluid that has entered the vessel through the or each flushing fluid opening (s) in the membrane is forced to flow in a retrograde direction between the treated stenotic lesion and the membrane.Type: ApplicationFiled: May 25, 2006Publication date: December 25, 2008Inventor: Leonid Shturman
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Publication number: 20080319424Abstract: Devices and methods for delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects. An implantable delivery device comprising a reservoir is initially attached to a deliver catheter or delivery tool and is introduced into the body and positioned at a desired site. A therapeutic or diagnostic substance is then introduced into the reservoir and the delivery catheter or deliver tool is then removed, leaving the implantable delivery device implanted within the body. The substance is then delivered from the reservoir at a rate that causes the desire diagnostic or therapeutic effect. Also provided are substance eluting stents that elute substance from a selected surface of the stent (e.g., the outer surface) but not from another surface of the stent (e.g., the inner surface).Type: ApplicationFiled: June 20, 2008Publication date: December 25, 2008Applicant: Acclarent, Inc.Inventors: Ketan P. Muni, Hung V. Ha, Joshua Makower, John H. Morriss, John Y. Chang, William M. Facteau, Amrish Jayprakash Walke
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Publication number: 20080294102Abstract: A vascular catheter with a circular external diameter, a circular lumen contained within, and an inflatable balloon that overlies a trough in the catheter body such that when the balloon is deflated, the balloon does not protrude beyond the outer circumference of the catheter shaft. The wall of the catheter shaft is thicker along one side than along the remainder of the circumference of the catheter shaft to permit an inflation lumen to be disposed within the thick wall section without increasing the outer diameter of the remaining portion of the circumference. The inflatable balloon is further disposed to maintain the circular lumen of the catheter in the center of flow of the blood vessel in which it is used, maintaining optimal flow.Type: ApplicationFiled: December 4, 2007Publication date: November 27, 2008Inventors: Richard Cartledge, Leonard Y. Lee
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Publication number: 20080281263Abstract: The present invention provides for a drug delivery mechanism for use with a protection device. The protection device has an expandable filter. The drug delivery mechanism automatically delivers a drug to the filter without requiring the intervention of the operator of the protection device. The drug delivered to the filter facilitates continued filter patency during the medical procedure.Type: ApplicationFiled: July 16, 2008Publication date: November 13, 2008Applicant: EV3 INC.Inventors: Kent D. Anderson, Richard S. Kusleika, Jennifer L. Pavlovic, Chad J. Volk, Gary A. Thill, Jeannine B. Baden
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Publication number: 20080269664Abstract: A treatment system (1600, 1900) is provided for traversing the alimentary tract. The system (1600, 1900) includes an ingestible capsule, which includes a gas pressurizing module (1602)) providing a gas and at least one balloon (1604, 1901) in fluid communication with the gas pressurization module (1602). The capsule further includes an exhaust channel (1610) in fluid communication with a respective balloon of the at least one balloon (1604, 1901), and a depressurizing closure member (1608) for selectively controlling flow of gas between the balloon (1604, 1901) and the ambient surroundings of the capsule. The system further includes control circuitry (906) for controlling the depressurizing closure member (1608).Type: ApplicationFiled: January 16, 2006Publication date: October 30, 2008Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Karen I. Trovato, Martin Ouwerkerk, Daniel Herzka, Judy R. Naamat
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Blood Flow Bypass Catheters and Methods for the Delivery of Medium to the Vasculature and Body Ducts
Publication number: 20080262467Abstract: A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, con-tinuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. Different embodiments of the catheterization device are disclosed and indications for the use of these devices in the treatment of vascular diseases are discussed.Type: ApplicationFiled: February 16, 2006Publication date: October 23, 2008Inventors: Joseph A.C. Humphrey, George T. Gillies -
Publication number: 20080243068Abstract: Methods and apparatus for the treatment of venous insufficiency, such as varicose veins, are described herein utilizing endovenous treatments. Such treatments may include systems to create an initial endovascular injury to the vessel wall utilizing any number of mechanisms, such as chemical, mechanical, electrical, etc. modalities. An implantable device, optionally having a sclerosing agent infused therein, may additionally be implanted along the injured tissue to promote, maintain, and otherwise enhance the tissue inflammation and scarring, thereby remodeling the diseased vessel wall.Type: ApplicationFiled: August 1, 2006Publication date: October 2, 2008Inventors: Kamal RAMZIPOOR, Ary CHERNOMORSKY
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Publication number: 20080208034Abstract: Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device proximal a target site within the vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.Type: ApplicationFiled: February 13, 2008Publication date: August 28, 2008Applicant: The Johns Hopkins UniversityInventors: Xiaoming Yang, Ergin Atalar, Christopher Yeung
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Publication number: 20080208118Abstract: A catheter for delivering an agent to an area of treatment is presented. The catheter includes a catheter body, a balloon assembly coupled to the catheter body, a first lumen, and a second lumen. The balloon assembly has spaced-apart balloons that define an area between the balloons. The first lumen extends along the catheter body to pass an inflation material to the balloons to control an inflation level of the balloons. The second lumen extends along the catheter body and having an outlet in the area between the balloons. There may be a third lumen for bypassing a biological fluid such as blood while the catheter is being used. The method of using this catheter is also presented. The method entails simultaneously inflating the balloons to isolate a treatment area and adding an agent to the treatment area through one of the lumens.Type: ApplicationFiled: January 9, 2008Publication date: August 28, 2008Applicant: Vascular Designs, Inc.Inventor: Robert J. Goldman
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Publication number: 20080177217Abstract: Treating of localized bacterial infection, comprising locally applying Taurolidine to the infection. A device for insertion into the body, the device comprising Taurolidine to render the device infection resistant. A medication for treating bacterial infections, comprising Taurolidine carried by one of: gels, liquid, thixotropic gels, colloidal mixtures, dispensal suspensions, injectable polymers, or a microparticle. A method for treating blood, comprising: removing blood from the body; treating the blood with Taurolidine; and returning the treated blood.Type: ApplicationFiled: May 16, 2005Publication date: July 24, 2008Inventor: Hans-Dietrich Polaschegg
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Publication number: 20080167609Abstract: The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient.Type: ApplicationFiled: March 18, 2008Publication date: July 10, 2008Inventors: Leo E. Otterbein, Augustine M. K. Choi, Fritz H. Bach, Brian Zuckerbraun
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Publication number: 20080154238Abstract: An endometrial ablation device comprising a shaft and inner and outer balloons connected to the shaft. The outer balloon has a plurality of pores on an outer surface. The inner balloon and outer balloon are independently inflatable such that the inner balloon is initially inflated to substantially fill the uterine cavity and the outer balloon is inflated subsequently. The outer balloon is filled with a treatment fluid which exits through the pores of the outer balloon.Type: ApplicationFiled: November 29, 2007Publication date: June 26, 2008Inventor: James F. McGuckin
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Publication number: 20080132835Abstract: The balloon catheter according to the present invention is one is provided with a catheter shaft having flexibility with a lumen formed inside; a balloon that is disposed at the distal end side of the catheter shaft and in communication with the lumen; a fluid regulating portion that passes a fluid that is supplied from a fluid supply source to the balloon and, simultaneous with the supply from the fluid supply source being stopped, prevents backflow of the fluid that is supplied to the balloon to the fluid supply source side; and a fluid releasing portion that releases the fluid that is supplied to the balloon to outside of the balloon.Type: ApplicationFiled: November 30, 2007Publication date: June 5, 2008Applicant: OLYMPUS CORPORATIONInventors: Ryuji NAGAMATSU, Yutaka YANUMA
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Publication number: 20080125710Abstract: The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating.Type: ApplicationFiled: August 7, 2006Publication date: May 29, 2008Inventors: Alex R. Hobson, Michael Houghton, David R. King, Joseph E. Korleski, Brian C. Lentz, Kenneth Newcomb, Peter J. Roeber, John Streeter
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Publication number: 20080119785Abstract: An internal compression tourniquet catheter system and method for wound track navigation for controlling hemorrhage from wounds. The preferred embodiments include an inflatable member constructed of thin, flexible, biocompatible, and puncture resistant material such that when deflated it lies flat and can be wrapped around the catheter shaft, which passes within and has a lumen to inflate it, to minimize overall diameter when deflated for insertion into the tissue track created by the wounding agent. The inflatable member is of large potential volume enabling full inflation with near zero internal pressure when unconstrained externally. When positioned within a wound track and inflated, the gas or liquid injected into the balloon lumen creates pressure because its expansion is constrained by the tissues of the wound, and that pressure is transmitted directly to the surrounding tissue of the wound track.Type: ApplicationFiled: August 13, 2006Publication date: May 22, 2008Inventors: Maynard Ramsey, Julian E. Cannon
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Publication number: 20080097297Abstract: The invention discloses a medical device and methods for site-specific diagnosis, energy therapy, sampling, and drug delivery in vivo with a catheter having at least a self-expandable piercing element and a drug delivery conduit.Type: ApplicationFiled: August 31, 2006Publication date: April 24, 2008Inventors: Gregory S. Kelley, Show-Mean S. Wu
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Patent number: 7338468Abstract: The present invention relates to a device and method for endoluminal delivery of fluid, such as therapeutic fluid, into the vessel wall that minimizes loss of the fluid. In one embodiment, a catheter for delivering fluid or therapeutic into a vessel wall is provided, wherein the catheter has at least one injector for delivering fluid and a sealing mechanism for preventing or minimizing passage of fluid through an unengaged injector.Type: GrantFiled: September 30, 2003Date of Patent: March 4, 2008Assignee: Boston Scientific Scimed, Inc.Inventor: Toby Freyman
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Patent number: 7244243Abstract: A catheter system for treating pulmonary emboli has an multi-channel access port for establishing and maintaining communication with the vascular system and provide guidance for endovascular catheterization. One catheter may traverse the port and extend through the heart to the pulmonary arteries to inject lysing agents, contrast media, medicaments and to remove blood clots. Another catheter may traverse the port and extend through the vena cava to other parts of the venous tree to supply the same agents and to remove blood clots there. A third catheter may telescope over the treatment catheter through the vena cava and occlude the affected vein. Gas pervious tubules on the third catheter provide oxygen enrichment of the venous blood.Type: GrantFiled: August 8, 2005Date of Patent: July 17, 2007Inventor: Banning Gray Lary
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Patent number: 7150738Abstract: A catheter assembly is provided having a balloon disposed at the distal end thereof. The balloon is capable of being inflated to selectively dilate from a collapsed configuration to an expanded configuration. A syringe assembly is in fluid communication with a delivery lumen of the catheter assembly for allowing a therapeutic substance to be injected into a tissue of a passageway. The syringe assembly includes a portion capable of pivoting from a first position towards a second position when the balloon is being inflated from the collapsed configuration to the expanded configuration. The portion of the syringe assembly is also capable of pivoting from the second position back towards the first position when the balloon is being deflated.Type: GrantFiled: October 10, 2002Date of Patent: December 19, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Pinaki Ray, Vinayak D. Bhat, Daryush Mirzaee
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Patent number: 7135029Abstract: The present invention relates, in general, to ultrasonic surgical instruments and, more particularly, to an intracorporeal ultrasonic surgical instrument for sonodynamic therapy. Disclosed is an ultrasonic surgical system comprising: a generator and an instrument comprising: a housing; a transducer; a semi-permeable membrane; a pharmaceutical agent; and an agent delivery system. The transducer is adapted to convert the electrical energy of the generator into mechanical energy. The pharmaceutical agent, delivered into a chamber of the semi-permeable membrane, is driven through the semi-permeable membrane by the mechanical energy.Type: GrantFiled: June 26, 2002Date of Patent: November 14, 2006Inventors: Inder Raj S. Makin, Jurgen Mensch, Marcus Joannes Noppe, Michael H. Slayton
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Patent number: 7105031Abstract: An endoluminal graft repair device includes a multi-lumen catheter with a balloon coupled to a distal end portion of the catheter. A portion of the outer surface of the balloon is designed and configured to define a repair cavity. A repair cavity lumen of the catheter is coupled to and in fluid communication with the repair cavity. The catheter and balloon are inserted into an artery system, advanced and positioned interluminally through percutaneous procedures so that the repair cavity is positioned to substantially align with the location of an endoluminal leak in an endoluminal graft used to treat aortic aneurysmal disease. The balloon is inflated by injecting an inflation fluid through an inflation lumen of the catheter into the balloon to fix the position of the repair cavity substantially adjacent the location of the endoluminal leak. A repair agent is conveyed to the repair cavity through the repair cavity lumen.Type: GrantFiled: April 26, 2002Date of Patent: September 12, 2006Assignee: Medtronic Vascular, Inc.Inventor: Michel Letort
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Patent number: 7066904Abstract: The invention features a method for triggering release of a drug from a hydrogel polymer to tissue at a desired location of the body using a catheter. A portion of the catheter is coated on its outer surface with a polymer having the capacity to incorporate a predetermined substantial amount of drug which is immobilized in the polymer until released by a triggering agent or condition that is different from physiological conditions. Upon contact with a triggering agent or condition, the polymer reacts, e.g., swells or contracts, such that the drug is delivered to the desired body tissue. A balloon catheter is shown in which the hydrogel is carried on the exterior surface of the balloon.Type: GrantFiled: October 25, 2002Date of Patent: June 27, 2006Assignee: Boston Scientific SciMed, Inc.Inventors: Arthur Rosenthal, James J. Barry, Ronald Sahatjian
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Patent number: 7048714Abstract: The present invention relates to a medical device and a method of delivering a drug to a target circulation or tissue. The medical device has an expandable portion which is fabricated from a porous elastomeric material with a plurality of voids therein. The voids are loaded with drugs in various formulations. Upon inflation of the expandable portion, the overall diameter increases, the wall thickness decreases and, consequently, the voids are stretched to cause the drug to be expelled from the voids and into the bodily lumen or tissue adjacent to the medical device. The voids include any open volume within the expandable portion capable of containing the drug.Type: GrantFiled: October 30, 2002Date of Patent: May 23, 2006Assignee: BIOrest Ltd.Inventor: Jacob Richter
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Patent number: 7034071Abstract: A polymer composite composing a polymer matrix having, dispersed therein, a nano clay in combination with a crosslinking promotor. In method form, the invention relates to a process for enhancing the mechanical properties of a polymer composite, comprising supplying a polymer matrix, combining the matrix with a nano clay and a crosslinking promotor and crosslinking.Type: GrantFiled: July 20, 2004Date of Patent: April 25, 2006Assignee: Foster CorporationInventors: Lawrence A. Acquarulo, Jr., Charles O'Neil, Jianwei Xu
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Patent number: 7022105Abstract: The invention provides a method and system for ablation of body structures or tissue in a sphincter, sinus or orifice such as the rectum, colon, esophagus, vagina, penis, larynx or pharynx. In one aspect of the invention, the environment surrounding the targeted ablation region can be isolated or controlled by blocking the flow of gases or liquids using an inflatable balloon positioned immediately adjacent to the tissue that is to be ablated. In a preferred embodiment, the inflatable balloon also serves to anchor the catheter in place and prevent the catheter from being expelled from the body. The inflatable balloon also insures that locally administered drug remain in the area where most needed. In a second aspect of the invention, positive pressure is used to inflate the balloon. Inflation of balloon triggers the extension of at least one curvilinear electrode into the targeted tissue.Type: GrantFiled: July 16, 1999Date of Patent: April 4, 2006Assignee: Novasys Medical Inc.Inventor: Stuart D. Edwards
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Patent number: 7018371Abstract: The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled radiosensitizer delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and radiosensitizer delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, banier, coating, infusion lumen, stent, graft, or reservoir for releasing an radiosensitizer to the body lumen.Type: GrantFiled: May 7, 2001Date of Patent: March 28, 2006Assignee: Xoft, Inc.Inventor: Michael R. Forman
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Patent number: 6991617Abstract: An intravascular catheter with micro spines that penetrate arterial wall to delivery drug or mechanical injury to the vessel wall inducing a “stent” like healing process in the vessel.Type: GrantFiled: August 21, 2003Date of Patent: January 31, 2006Inventors: Thomas R. Hektner, Edward S. Andrle, Chad Kugler, Matt Olson
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Patent number: 6958059Abstract: A method for delivering a drug to the site of an intravascular occlusion. A guidewire having a balloon at one end is advanced across the occlusion using a guide catheter, and the balloon is inflated distal to the occlusion to occlude the blood vessel. An aspiration catheter is then inserted into the vessel with its tip less than about 5 mm from the surface of the balloon, and a drug is delivered which flows distal to proximal to treat the occlusion.Type: GrantFiled: December 28, 2001Date of Patent: October 25, 2005Assignee: Medtronic Ave, Inc.Inventor: Gholam-Reza Zadno-Azizi
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Patent number: 6955661Abstract: A radially expandable fluid delivery device for delivering a fluid to a treatment site within the body is disclosed. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. The fluid delivery device includes a tubular member defined by a wall having a thickness transverse to the longitudinal axis of the tubular member and extending between an inner and an outer surface. The wall is characterized by a microstructure of nodes interconnected by fibrils. The tubular member is deployable from a first, reduced diameter configuration to a second, increased diameter configuration upon the introduction of a pressurized fluid to the lumen.Type: GrantFiled: October 1, 1999Date of Patent: October 18, 2005Assignee: Atrium Medical CorporationInventors: Steve A. Herweck, Peter H. Gingras, Paul Martakos, Theodore Karwoski
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Patent number: 6939593Abstract: This invention relates to medical devices containing melt-processible polytetrafluoro-ethylene (PTFE) and methods of making same.Type: GrantFiled: August 27, 2001Date of Patent: September 6, 2005Assignee: SciMed Life Systems, Inc.Inventor: Lixiao Wang
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Patent number: 6925327Abstract: Devices and methods for testing a pulmonary vein to determine whether or not ablation would be effective in terminating atrial fibrillation. The devices and methods include a catheter having an expandable balloon attached to the distal end of the catheter. The balloon has pores on the distal end of the balloon for administering a fluid into the target pulmonary vein. The fluid inhibits the electrical impulses generated by the target pulmonary vein. Once the electrical impulses of the target pulmonary vein have been inhibited it can be determined whether or not the atrial fibrillation continues to occur. If the atrial fibrillation has been eliminated, then ablation or other therapy is appropriate. Thus, the devices and methods limit unnecessary treatment of a pulmonary vein.Type: GrantFiled: June 10, 2003Date of Patent: August 2, 2005Assignee: BioCardia, Inc.Inventor: Peter A. Altman
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Patent number: 6884234Abstract: The present invention is directed to a polymeric balloon for an intracorporeal catheter having a plurality of spaced apart, remotely imageable layers which facilitate the folding of the balloon. The imageable layer may facilitate imaging the balloon or a portion thereof preferably by fluoroscopic or magnetic resonance based remote imaging systems.Type: GrantFiled: November 1, 2001Date of Patent: April 26, 2005Assignee: Cardio Exodus PartnersInventors: Michael Aita, Milan Mursec
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Patent number: 6878291Abstract: Embolic protection filtering devices and methods of making and using the same. The present invention may include an embolic protection filtering device including a filter cartridge that is slidable over medical devices, for example, guidewires. The filter cartridge may have a filter coupled thereto and may have desirable flexibility and trackability characteristics, for example, imparted by manufacturing the cartridge to include notches or a spiraling groove, or a coil disposed along the length of the cartridge. The filtering device may be advanced through a blood vessel to a target location, and expanded followed by advancing a therapeutic device over the guidewire and filtering debris generated by the therepeutic device with the filter.Type: GrantFiled: February 24, 2003Date of Patent: April 12, 2005Assignee: SciMed Life Systems, Inc.Inventors: Brian J. Lowe, Alan D. Eskuri
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Patent number: 6835188Abstract: The present invention relates to a catheter or cannula system that facilitates cardiopulmonary bypass surgeries and enables prolonged circulatory support of the heart. More specifically, the present invention provides an aortic catheter system including a porous aortic root balloon capable of occluding the aorta, delivering cardioplegia and providing tactile feedback and helping to maintain the competency of regurgitant aortic valves.Type: GrantFiled: July 31, 2001Date of Patent: December 28, 2004Assignee: Cardeon CorporationInventors: Wilfred J. Samson, Janine Robinson, Steve Baker, James J. Leary
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Publication number: 20040236308Abstract: A method of delivering a therapeutic agent to a targeted location within a patient efficiently delivers the agent with a reduced systemic effect. The method includes providing a non-perforated delivery device having at least one wall through which a fluid at first fluid pressure can pass through. The non-perforated delivery device is positioned to provide a radial fluid force against the targeted location. The fluid, including at least one therapeutic agent, is supplied to the therapeutic agent delivery device at the first fluid pressure. The fluid passes through the at least one wall of the delivery device to create a semi-confined space external to the delivery device at a second fluid pressure. The delivery device applies the radial fluid force against the semi-confined space and the fluid disposed therein while simultaneously facilitating the fluid passing through the delivery device to maintain the second fluid pressure in the semi-confined space at the targeted location.Type: ApplicationFiled: May 22, 2003Publication date: November 25, 2004Applicant: ATRIUM MEDICAL CORP.Inventors: Steve A. Herweck, Paul Martakos, Geoffrey Moodie, Roger Labrecque
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Publication number: 20040236279Abstract: A therapeutic delivery device includes a non-perforated insufflating shaped form, such as a catheter irrigating shaped form, coupled to a first gas source. The insufflating shaped form is sized and dimensioned for positioning within a patient body. A second gas is stored within the insufflating shaped form. The second gas can be stored within an inner chamber of the insufflating shaped form, within the walls of the insufflating shaped form, or the like. In a corresponding method, a first gas reacts with the second gas upon delivery of the first gas from the first gas source through the insufflating shaped form. The reaction forms a gas mixture, which emits from the insufflating shaped form to a targeted location within the patient body. The insufflating shaped form serves to maintain a predetermined concentration of the gas mixture at the targeted location for a desired dwell time.Type: ApplicationFiled: May 22, 2003Publication date: November 25, 2004Applicant: ATRIUM MEDICAL CORP.Inventors: Steve A. Herweck, Paul Martakos
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Publication number: 20040230176Abstract: The present invention provides a system for treating a vascular condition that inhibits restenosis at the ends of a stent by delivering a therapeutic agent to the vessel wall at and beyond the stent ends. The system comprises a catheter, a stent, and a therapeutic agent. The catheter includes an inflatable balloon. The stent is operably coupled to the balloon. The therapeutic agent is disposed on at least a portion of the balloon and is delivered to a wall of a vessel at a proximal and a distal end of the stent when the balloon is inflated. The therapeutic agent may also be disposed on at least a portion of the stent. The system may further comprise a protective coating disposed under the therapeutic agent, over the therapeutic agent, or both under and over the therapeutic agent.Type: ApplicationFiled: April 21, 2004Publication date: November 18, 2004Applicant: Medtronic Vascular, Inc.Inventors: John P. Shanahan, John E. Nolting, Kevin M. Mauch, Zachary J. Woodson
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Patent number: 6796960Abstract: Medical devices that are configured for insertion into a body lumen, such as the male urethra, are provided with one or more inflatable balloons having elastic sleeves, wherein each elastic sleeve is adapted to inflate in response to inflation of a respective balloon, and to deflate in response to deflation of the respective balloon. When a balloon is in a deflated condition, a respective elastic sleeve exerts a circumferentially compressive force against the balloon to cause a smooth, reduced cross-sectional profile of the balloon along an axial extent thereof. This smooth, reduced cross-sectional profile can facilitate passage of the medical device through a body lumen during both insertion and extraction of the medical device. A thin layer of fluid may be disposed between a treatment balloon and a respective elastic sleeve to facilitate heat transfer from a treatment balloon to a surrounding elastic sleeve or to administer a therapeutic agent to localized tissue.Type: GrantFiled: May 1, 2002Date of Patent: September 28, 2004Assignee: WIT IP CorporationInventors: Iulian Cioanta, Jacob Lazarovitz
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Publication number: 20040153048Abstract: A method for preventing a restenosis within a vessel wall requires a medicament be delivered at predetermined locations into the vessel wall and allowed to subsequently disperse in a predetermined pattern. To deliver the medicament, a catheter with an expanding member is advanced into the vasculature of a patient until the expanding member is located as desired. The expanding member is then expanded to force dispensers into the vessel wall to the proper depth. A medicament is then pumped through the dispensers to create a plurality of equally spaced, localized medicinal deliveries which subsequently disperse to medicate an annulus shaped volume within the vessel wall.Type: ApplicationFiled: January 22, 2004Publication date: August 5, 2004Inventors: Dennis M. Vigil, Robert E. Reiss, Peter Barath
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Patent number: 6743197Abstract: A method and system for treating body structures or tissue allows treatment by any of ablation, coating, expansion, plumping, shaping, and shrinking. Treatment sitesinclude any of a sphincter, sinus or orifice. During treatment, electrodes emerge from apertures in a balloon. The balloon with liquid from a circulating bath cools tissue in direct contact with electrodes and immediately adjacent, so that discrete regions are treated, with minimal damage to adjacent structures. Sensors, coupled to electrodes, measure treatment properties such as: temperature, impedance and nervous activity. Measurements are used for: diagnostic assessment, determining treatment parameters, providing nervous stimulation and/or blocking, and feedback for controlling energy delivery. The catheter includes an optical path that can be coupled to external viewing apparatus. Endoscopic methods, including fluoroscopic, fiber optic, or radioscopy allow examining tissue and determining position of electrodes.Type: GrantFiled: July 2, 1999Date of Patent: June 1, 2004Assignee: Novasys Medical, Inc.Inventor: Stuart D. Edwards
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Publication number: 20040102733Abstract: There is provided a minimally-invasive smart device which can detect enviornmental conditions in the vicinity of a target site within a patient's body and autonomously determine whether the medical device on the distal end of the instrument should be activated to perform, or inhibited from performing, a desired minimally-invasive medical procedure. The smart device includes a medical device affixed to the distal end of a lumen, at least one environmental condition sensor adapted to detect an environmental condition adjacent to the medical device, and at least one medical device actuator which responds to signals from an environmental condition sensor to either cause the medical device to perform the desired medical procedure or to inhibit operation of the medical device actuator.Type: ApplicationFiled: November 21, 2002Publication date: May 27, 2004Inventors: Wendy Naimark, Henry Tung, Maria Palasis
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Publication number: 20040097877Abstract: The present invention relates generally to multifunctional devices for performing suction, irrigation, and manipulation at an internal site in a subject, and more particularly to enlargeable multifunctional devices for performing such functions while avoiding obstruction during conventional and endoscopic surgery. The present invention eliminates many of the problems associated with malleable tissue obstruction during surgery by providing the ability to deploy and retract a guard (e.g. enlargeable section) to create an area free of tissue interference.Type: ApplicationFiled: June 30, 2003Publication date: May 20, 2004Inventor: Eric C. Stecker
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Patent number: 6733474Abstract: A combination dilatation and drug delivery device includes a flexible catheter, a drug delivery sheath mounted to a distal end region of the catheter and a dilatation balloon also mounted to the catheter and contained within a compartment formed by the sheath. The sheath is radially expandable by supplying a liquid therapeutic agent to the compartment under a moderate pressure. The dilatation balloon is expandable by providing a dilatation fluid to the balloon under a much higher pressure. The sheath can be formed of a highly elastic material or can be made quite thin, and in either case is mounted independently of the dilatation balloon. Thus when radially expanded, the sheath is moved into a conforming contact with surrounding vascular tissue. The conforming contact protects tissue and the therapeutic agent from exposure to blood, and more effectively confines the therapeutic agent to the intended treatment area.Type: GrantFiled: March 22, 2001Date of Patent: May 11, 2004Assignee: SciMed Life Systems, Inc.Inventor: Richard S. Kusleika
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Publication number: 20040064093Abstract: An intravascular catheter with micro spines that penetrate arterial wall to delivery drug or mechanical injury to the vessel wall inducing a “stent” like healing process in the vessel.Type: ApplicationFiled: August 21, 2003Publication date: April 1, 2004Inventors: Thomas R. Hektner, Edward S. Andrle, Chad Kugler, Matt Olson
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Publication number: 20040064094Abstract: The present invention relates to a device and method for endoluminal delivery of fluid, such as therapeutic fluid, into the vessel wall that minimizes loss of the fluid. In one embodiment, a catheter for delivering fluid or therapeutic into a vessel wall is provided, wherein the catheter has at least one injector for delivering fluid and a sealing mechanism for preventing or minimizing passage of fluid through an unengaged injector.Type: ApplicationFiled: September 30, 2003Publication date: April 1, 2004Inventor: Toby Freyman