Abstract: A vasoocclusive coil is reinforced with a stretch resistant member to improve safety during retraction of the coil. The stretch resistant member is fixedly attached at one end to the vasoocclusive coil, and the other end of the stretch resistant member is detachably mounted to an elongated pusher member to allow for placement and release of the vasoocclusive coil within the patient's vasculature.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: There are disclosed embodiments of a system for thermochemical tissue ablation. An ablation needle in the form of a cannula with a tip and a plurality of tubes or lumens therethrough is provided, with the tip forming a hollow mixing chamber without external openings. Liquid reagents are passed through the lumens or tubes to the mixing chamber, where an exothermic reaction results, heating the tip. The heated tip is used for tissue ablation. The reaction product can be at least partially evacuated from the mixing chamber through a tube or lumen that empties into a container.

Abstract: In one embodiment, an exsanguination preventing device includes a collection container having an inlet configured to receive blood from a patient and an outlet configured to discharge the blood; a pump operatively coupled to the collection container; a conduit fluidly coupled to the collection container, which receives the blood from the collection container, the blood being moved by the pump; and an insertion device, which delivers the blood from the conduit to a bodily part of the patient. The collection container is configured to be sealingly coupled to a wound on the patient and air entrapped within the exsanguination preventing device is removed by an air removal system, such to prevent unwanted discharge of air into the bodily part of the patient. All the components of the exsanguination preventing device are sized such to make it portable in a pocket of a garment or backpack of a soldier.

Abstract: A cooling device includes a target fluid inlet, a target fluid outlet, an inner conduit, and a chamber surrounding the inner conduit. The inner conduit communicates with the target fluid inlet and the target fluid outlet, and provides a flow path for a target fluid to be cooled. The chamber contains a first endothermic reactant and includes a reactant inlet selectively alterable from a closed state to an open state. When the reactant inlet is in the closed state, the first endothermic reactant is isolated from a second endothermic reactant and no endothermic reaction occurs. When the reactant inlet is in the open state, the reactant inlet provides a flow path for enabling the second endothermic reactant to come into contact with the first endothermic reactant in the chamber for initiating the endothermic reaction and cooling the target fluid in the inner conduit.

Abstract: Novel fluid delivery systems are disclosed to improve the delivery of bio-compatible fluids to a patient. The systems can include a housing having a bladder pressurized by a pressurization unit so that fluid flow rate can be controlled, changed and/or monitored. The systems can also include a scale and/or a flow control unit.

Abstract: Surgical fluid management systems and methods of operating surgical fluid management systems which may provide one or more functions associated with suction, irrigation, distention, deficit monitoring, infusion, fluid warming, and the like. Some example embodiments may include infra-red lamps arranged to heat fluid flowing through a disposable cartridge. Some example embodiments may provide a three-dimensional fluid path through the cartridge and/or multi-stage heating capabilities. Some example fluid management systems may be selectable between pressure control and flow control modes.

Abstract: A cooling system for an indwelling heat exchange catheter includes a heat exchange bath that is configured to receive a conduit that carries saline to and from the catheter. A heating/cooling fluid is in the bath and exchanges heat with the saline. The heating/cooling fluid flows through a heat exchanger that includes a refrigerant and two variable speed DC compressor for removing heat from the refrigerant. A gear pump circulates the working fluid to and from the catheter and is removably engaged with a pump support platform.

Abstract: A heating system for heating neonate nutritional liquid, including a heater and a control module. The heater includes a heating portion having serpentine shaped grooves for receiving a tube. The tube may be a serpentine feeding tube module, having a serpentine tube portion, or a serpentine feeding tube cassette, having a serpentine tube portion covered by a rigidly attached polymeric sheet. The serpentine feeding tube cassette may include a thermocouple to measure the temperature of the warmed nutritional liquid as it exits the cassette.

Abstract: A bioactive agent delivery device having a plurality of reservoirs wherein each reservoir houses a solvent provides a means for separable and segregated delivery of bioactive agent(s) to a patient. The device can include a plurality of absorbent materials wherein each absorbent material is pretreated with a bioactive agent and a delivery mechanism operable to deliver to any of the plurality of absorbent materials a controlled portion of solvent from any of a plurality of reservoirs. A diffusion layer interposed between the absorbent materials and an epidermis transfers the bioactive agent from the absorbent materials to the epidermis for delivery of the bioactive agent.

Abstract: The disclosure provides a thermotherapy needling instrument with tissue injection, including: a casing, an outer needle, an inner needle and a working needle. The casing has an inlet, an outlet and an inner channel. The outer needle is connected to the casing, and is in communication with the inner channel. The inner needle is disposed in the inner channel of the casing and the outer needle, and the inner needle has at least one opening The at least one opening is in communication with the inner channel so that the cooling agent flows in circulation. The working needle is connected to the outer needle so as to receive the injectant for injection and tissue ablation. By using the thermotherapy needling instrument, when sampling or injection is required during thermotherapy, the injection efficacy can be achieved by withdrawing the inner needle only. Therefore, efficacy of tissue injection and ablation thermotherapy can be achieved.

Abstract: This disclosure relates to medical temperature sensors and related systems and methods. In some aspects, a sensor assembly includes a non-invasive temperature sensor to detect a temperature of a medical fluid in a medical fluid line and an ambient temperature sensor to detect an ambient air temperature.

Abstract: The present invention relates to a portable apparatus for warming biocompatible fluids for use in the treatment of injured patients and a method of heating a biocompatible fluid to treat a patient experiencing hypothermia. The present invention may be used to warm intravenous fluids for trauma resuscitation or to warm air from a ventilator circuit. The portable nature of the present invention makes it highly suitable for field applications, such as a forward surgical hospital near a combat zone.

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: A catheter-based medical device includes a catheter that is configured and arranged for at least partial insertion into a patient and that defines at least one lumen that is configured and arranged to receive a first fluid. A conductive-fluid detector is coupled to the at least one lumen and is configured and arranged to detect when a second fluid is disposed within the at least one lumen that is more conductive than the first fluid. The conductive-fluid detector includes a plurality of axially-positioned bodies, each body defining a lumen. The lumens of the axially-positioned bodies are aligned to form a shared lumen in fluid communication with the at least one lumen of the catheter. Spaced apart electrodes are disposed within the shared lumen.

Abstract: A compound for injecting locally into an intratumoral space of a body made of a mixture of a biocompatible wax, admixed with biocompatible oil. The compound is liquid at a temperature above body temperature but compatible with the life of healthy cells. It exhibits an increasing viscosity with decreasing temperature and becomes a solid close to body temperature. The compound is then metabolized by the human body.

Abstract: A disposable cassette (1) is disclosed having an inlet port (4), an outlet port (5), and a heat exchanger element (3) with a fluid flow channel (9, 10, 15, 29) defined therein, the element being configured for conductive heat transfer between an exterior source and liquid in the fluid flow channel through at least one wall member of the heat exchanger element. The average cross sectional area of the outlet part of the fluid flow channel is substantially smaller than the average cross sectional area of the inlet part of the fluid flow channel. Furthermore is disclosed an assembly for connecting a source of intravenous fluid to a patient, the assembly comprising a sealed sterile packaging enclosing the disposable cassette, a first tube for connecting said source of intravenous fluid to the inlet port of the disposable cassette, and a second tube for connecting the outlet port of the disposable cassette to an intravenous catheter.

Abstract: An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Abstract: A heating system for warming nutritional liquid fed to a neonate or preterm infant may comprise a control module and a heater. The heating system is portable so that the heating system is not connected to a syringe pump or other device used to feed the neonate. The heater of the heating system is mounted to the tube that is used to feed the neonate. The heater is positioned along the tube in close proximity to the neonate so that a temperature drop of the nutritional liquid after the nutritional liquid exits the heater and reaches the neonate is negligible. The heater raises the temperature of the nutritional liquid to a target desired temperature (e.g., body temperature of the mother and neonate or to a temperature above the temperature of the mother and neonate) so that the neonate may consume warm nutritional fluid. Once the nutritional liquid reaches the neonate, the nutritional liquid is at about the body temperature of the mother or neonate or at least above room temperature.

Abstract: A therapeutic rinse for treating a sore throat including a self heating container having a reservoir. The self heating container is capable of reaching a temperature of at least 130 degrees Fahrenheit when activated. The therapeutic rinse includes a liquid composition having sodium chloride, water, an antibiotic, and a variety of vitamins, minerals and herbs stored in the reservoir of the self heating container. During use, the self heating container is activated and the liquid composition is heated inside the reservoir to about 130 degrees Fahrenheit.

Abstract: An apparatus heats fluids. A number of lithium-ion cells are positioned within a housing. A first connector is positioned on a first end of the housing and operably connected to the number of lithium-ion cells. The first connector is configured to receive electrical power from a power source. A second connector is positioned on a second end of the housing and operably connected to the number of lithium-ion cells. A heating element has a tube for transferring fluid. The heating element is configured to connect to the second connector. A controller is positioned within the housing and operably connected to the number of lithium-ion cells and the second connector. The controller is configured to monitor a rate at which the electrical power is received by the heating element and limit an amount of the electrical power received by the heating element when the rate reaches a predetermined level.

Abstract: A cooling system for an indwelling heat exchange catheter includes a heat exchange bath that is configured to receive a conduit that carries saline to and from the catheter. A heating/cooling fluid is in the bath and exchanges heat with the saline. The heating/cooling fluid flows through a heat exchanger that includes a refrigerant and two variable speed DC compressor for removing heat from the refrigerant. A gear pump circulates the working fluid to and from the catheter and is removably engaged with a pump support platform.

Abstract: Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.

Abstract: Devices and methods are provided for aspirating adipose tissue with a portable device. This device may include a processing chamber, a cannula, a vacuum source, a filter or screen for separating connective tissue strands from adipose tissue, a digestion area, and a product cell concentration chamber.

Abstract: Embodiments of the invention provide apparatus, systems and methods for introducing fluids into a body cavity for hypothermic, resuscitative, or other treatment. One embodiment provides an apparatus for introducing fluids into a peritoneal cavity comprising an access device for insertion into subcutaneous tissue, an infusion member and an advancement member. The access device includes a lumen, a proximal end, a tissue penetrating distal end and a stop for controlling the depth of the distal end into tissue. The infusion member includes an infusion lumen, a removal lumen and at least one sensor and is advanceable from a lumen of the access device into the peritoneal cavity. The advancement member is removably positionable in an infusion member lumen and has sufficient column strength to advance the infusion member tip through abdominal wall tissue into the peritoneal cavity. When the advancement member is removed, the infusion member tip is substantially atraumatic.

Abstract: Medicament devices include a sealed medicament dose container comprising a cell based medicament that is stored at a temperature less than about ?40 degrees Celsius, then thawed into a liquid prior to administration and a medicament dose cartridge configured and sized to snugly hold the dose container therein during extraction of the liquid medicament. Related dose containers, retainers and extraction/dispensing systems are also described.

Abstract: Heat transfer catheter apparatus and methods of making and using same are disclosed wherein fluid connection means is provided between the distal portions of two adjacent, thin-walled, high strength fluid lumens to define a closed loop fluid circulation system capable of controlled delivery of thermal energy to or withdrawal of thermal energy from remote internal body locations.

Abstract: A heating system for warming nutritional liquid fed to a neonate or preterm infant may comprise a control module and a heater. The heating system is portable so that the heating system is not connected to a syringe pump or other device used to feed the neonate. The heater of the heating system is mounted to the tube that is used to feed the neonate. The heater is positioned along the tube in close proximity to the neonate so that a temperature drop of the nutritional liquid after the nutritional liquid exits the heater and reaches the neonate is negligible. The heater raises the temperature of the nutritional liquid to a target desired temperature (e.g., body temperature of the mother and neonate or to a temperature above the temperature of the mother and neonate) so that the neonate may consume warm nutritional fluid. Once the nutritional liquid reaches the neonate, the nutritional liquid is at about the body temperature of the mother or neonate or at least above room temperature.

Abstract: A cooling device and method inhibit the infectious growth of pathogens in a body cavity, primarily to cure VulvoVaginal Candidiasis (VVC) and Bacterial Vaginosis (BV) in the vagina, and to reduce biofilms. The device has a shell having an internal chamber containing a freezable or cooling filler that reduces the body cavity temperature. The device may be comprised of an optional coating compound (agent) covering at least a portion of an outer surface of the shell and an optional stainless steel sleeve that covers the shell or optional stainless steel particles that are impregnated into the shell material to enhance both thermal conductance and cooling efficacy. Pathogenic biofilms dissolve and bacteria colony counts decrease at lowered temperatures in body cavities, and infectious, temperature sensitive organisms (fungi, yeast, bacteria, viruses, parasites, and protozoans) become dormant, change morphology, or cease growing under the same lowered body cavity temperatures.

Abstract: Disclosed is an exemplary surgical system employing a temperature controlled docking station. The surgical system may include an articulating arm that is selectively moveable within a range of positions. A tray for receiving items used in performing a procedure may be attached to the articulating arm. The docking station may be attached to the tray. The docking station may include a heating element for selectively heating the docking station, a temperature sensor for monitoring a temperature of the docking station, and a reader configured for collecting information associated with an article placed in the docking station. The surgical system may also include a controller operably connected to the heating element, the temperature sensor, and the reader. The controller may be configured to adjust a heat output of the heating element in response to a signal received from the temperature sensor and/or the reader.

Abstract: A fluid warming device may include a housing comprising a main body, a heat exchange body receiving compartment, and a cover movably coupled to the main body between an open position and a closed position; a heater assembly disposed within the main body and having a heat conducting surface disposed proximate the heat exchange body receiving compartment; and a heat exchange body removably disposable in the heat exchange body receiving compartment of the main body and having an input port and an output port to couple the heat exchange body to tubing to flow a fluid to be warmed through the heat exchange body. In another aspect, a fluid warming system increases or decreases power to a heater assembly to adjust the fluid temperature to ensure that the fluid is at an appropriate temperature when it reaches the patient.

Abstract: A balloon catheter is used in a closed-loop heat exchange system for manipulating the temperature of a patient. The balloon catheter is positioned in the stomach of the patient, and then expanded with a heat exchange fluid delivered through a lumen formed in the shaft of the catheter. The balloon catheter comes into contact with the wall of the stomach, and the stomach substantially conforms around the expanded balloon catheter. The heat exchange fluid is allowed to flow continuously into and out of the balloon catheter. Heat is exchanged between the balloon catheter and the stomach so as to controllably alter the temperature of at least a portion of the patient. Anti-shivering mechanisms and automatic control based on temperature feedback from the patient may be used in connection with the heat exchange system.

Abstract: A cooling device includes a target fluid inlet, a target fluid outlet, an inner conduit, and a chamber surrounding the inner conduit. The inner conduit communicates with the target fluid inlet and the target fluid outlet, and provides a flow path for a target fluid to be cooled. The chamber contains a first endothermic reactant and includes a reactant inlet selectively alterable from a closed state to an open state. When the reactant inlet is in the closed state, the first endothermic reactant is isolated from a second endothermic reactant and no endothermic reaction occurs. When the reactant inlet is in the open state, the reactant inlet provides a flow path for enabling the second endothermic reactant to come into contact with the first endothermic reactant in the chamber for initiating the endothermic reaction and cooling the target fluid in the inner conduit.

Abstract: An object of the present invention is to provide a heat generating body giving no uncomfortable feeling when in use and causing no direct close contact between a heat generating member and the skin by an adhesive to relieve the burden of the skin while eliminating a low temperature burn even for a person with a delicate skin and in the case of continuous use. The heat generating body of the present invention is characterized in that the heat generating member having a wide surface is provided on a mesh-like sheet larger in outer shape than the one-side wide surface of the heat generating member and that an adhesive layer is provided on the mesh-like sheet located at the outer peripheral part of the heat generating member.

Abstract: In various embodiments, an ophthalmic injection device may include a dispensing chamber, a first thermal sensor coupled to the dispensing chamber, a temperature control layer coupled to the dispensing chamber, a second thermal sensor coupled to the dispensing chamber, and a first processing device. The first processing device may be configured to receive temperature information from the first thermal sensor and the second thermal sensor and control the temperature control layer using the received temperature information. In some embodiments, the first processing device may receive temperature information directly from the second thermal sensor (e.g., in analog form) and may compare the temperature information from the first thermal sensor (e.g., received from the second processing device in digital form) and the second thermal sensor to detect temperature offsets between the two sensors.

Abstract: Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods described herein. The methods involve flushing a patient with an oxygenated, cold-flush solution, such as normal saline, having an energy source. The patient may be cooled to deep or profound hypothermia to induce preservation. The patient may be resuscitated by warming to from about 33° C. to about 36° C., and then may be slowly warmed over a 24 to 72 hour period to normothermia. Kits for inducing preservation also are provided.

Abstract: Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.

Abstract: A fluid warming cassette for use in a fluid warming system includes a first sheet, a second sheet and a flexible spacer having a serpentine opening. At least one of the first and second sheets is a flexible plastic sheet. The spacer is positioned between the first and second sheets and the first and second sheets are joined together over the spacer to form a fluid container having a fluid channel. The fluid container includes a fluid channel with inlet and outlet ports in fluid communication with the fluid channel. The fluid warming cassette is capable of operating under negative pressure without collapse of the fluid channel in the cassette.

Abstract: A heat exchanger has a multi-lumen tubing having one end connected to a supply fitting and another end connected to a return fitting. The tubing has a central lumen, a middle lumen that surrounds the central lumen and an outer lumen that surrounds the middle lumen. When infusate traverses along the heat exchanger, it is heated by the heating fluid that flows along the central lumen, and also by the rerouted heating fluid that flows along the outer lumen of the tubing. The heat exchanger is fluidly coupled to a heater by its inlet and outlet so that the temperature of the heating fluid for warming the infusate is maintained at a predetermined temperature.

Abstract: A cooling device includes a target fluid inlet, a target fluid outlet, an inner conduit, and a chamber surrounding the inner conduit. The inner conduit communicates with the target fluid inlet and the target fluid outlet, and provides a flow path for a target fluid to be cooled. The chamber contains a first endothermic reactant and includes a reactant inlet selectively alterable from a closed state to an open state. When the reactant inlet is in the closed state, the first endothermic reactant is isolated from a second endothermic reactant and no endothermic reaction occurs. When the reactant inlet is in the open state, the reactant inlet provides a flow path for enabling the second endothermic reactant to come into contact with the first endothermic reactant in the chamber for initiating the endothermic reaction and cooling the target fluid in the inner conduit.

Abstract: A vasoocclusive coil is reinforced with a stretch resistant member to improve safety during retraction of the coil. The stretch resistant member is fixedly attached at one end to the vasoocclusive coil, and the other end of the stretch resistant member is detachably mounted to an elongated pusher member to allow for placement and release of the vasoocclusive coil within the patient's vasculature.

Abstract: Systems and methods of tissue remodeling or altering a surface of a skin of a patient are provided. A method includes increasing myostatin activity in a target tissue. Methods can include increasing myostatin activity in a target tissue in addition to various tissue remodeling techniques, including cryogenic cooling of target tissue for tissue remodeling.

Abstract: Methods are describe for treating intraluminal locations such as in a patient's lung. The device is a catheter which has an elongated shaft with an inner lumen, preferably defined by an inner tubular member, formed of heat resistant polymeric materials such as polyimide and high temperature vapor is directed through the inner lumen into the intraluminal location to treat tissue at and/or distal to the location. The outer surface of the catheter is also formed of heat resistant material. An enlarged or enlargeable member, such as a balloon, is provided on a distal portion of the catheter shaft to prevent proximal flow of the high temperature vapor upon discharge from the catheter.

Abstract: A portable, disposable, thermal drug dispensing apparatus and method of thermally controlling the delivery of medication therewith is provided. The apparatus provides a predetermined thermal energy over a predetermined amount of time to allow effective drug delivery regardless of the external environment. The apparatus produces exothermic or endothermic thermal energy, in a balanced and controlled environment via a chemical reaction between reactants contained as an integral part within the apparatus. The reactants are provided and automatically combined in a selective, predetermined manner within the apparatus to provide the desired thermal cycle needed to produce the desired, thermal environment for effective drug treatment.

Abstract: Methods and devices for treating patients using high partial pressures of dissolved gas in a liquid. Greater than hyperbaric partial pressures of gas may be dissolved and maintained in the liquid when mixing occurs at ambient pressure. Additional increases in dissolved gas partial pressure may be achieved when the temperature of the liquid is further decreased. The method further includes administering the liquid intravenously via a conventional catheter. Gas exchange occurs due to diffusion upon mixing of the liquid and blood within the vasculature of the patient.

Abstract: The present application relates to a system for the delivery of heated therapeutic fluid to a patient's body cavity, said system comprising a device, said device comprising a heating element and a pump; and a tubing system, said tubing system comprising at least one length of tubing, a heat exchanger and at least one in-line temperature sensor. The present application further relates to a method of treating a patient using heated therapeutic fluids within a patient's body cavity, said method comprising the steps of heating the therapeutic fluid using a device comprising a heating element and a pump; and pumping the therapeutic fluid so that it is delivered to the patient's body cavity by means of a tubing system comprising at least one length of tubing, a heat exchanger and at least one in-line temperature sensor.

Abstract: This invention is directed to a portable intravenous fluid heater that can weight less than 10 oz having an internal power supply internal tubing that is heated by a heating element; a logic assembly; an external power terminal for connecting an external power supply; and computer readable instructions, that when executed by the processor, perform the steps of receiving output temperature from the fluid output heat sensor, removing power from the heating element if the output temperature is above a predetermined temperature to reduce the temperature of fluid exiting the tubing and delivering power to the heating element when the output temperature is below a predetermined temperature.

Abstract: A drug-delivery chip and a method of fabricating the same are provided. The drug-delivery chip has a main body having at least one drug receiving space individually formed with an opening for storing drugs therein; a thin film for sealing up the at least one drug receiving space; a first conductive wire connecting to one end of the thin film; a second conductive wire connecting to another end of the thin film; a signal-receiving module for receiving actuated signals; and a control module for applying voltages to first and second wire conductive s according to the actuated signal, thereby generating heat to break off the thin film for the release of a drug or drugs received in the at least one drug receiving space.

Abstract: A device (10) for warming infusion or transfusion fluids by an exothermic reaction of a reactive liquid, including at least one reaction chamber (11) containing a trigger, and a passageway (12) extending through said reaction chamber (11) for movement of said infusion or transfusion fluids therethrough, wherein the reactive liquid is introduced into said reaction chamber (11), being at least partially evacuated of air, to thereby initiate said exothermic reaction.