Abstract: An autoinjector includes a case, a syringe carrier slidably disposed within the case and adapted to hold a syringe including a stopper, a plunger slidably disposed within the syringe carrier and adapted to apply a force on the stopper, and a drive spring disposed within the plunger and biasing the plunger relative to the syringe carrier.

Abstract: A device for adjusting the tightening angle of a needle safety protector is proposed. The device is configured to provide an injection needle in an integrated state with a needle hub for preventing reuse of the injection needle and to fasten the needle hub to a needle safety protector that is disposed of in a folded state after use, a fastening structure is improved such that rotation is possible by a predetermined angle when the needle safety protector is rotated. Accordingly, an injection is safely performed by correcting the injection needle to the reference direction. In addition, even when a syringe is assembled by deviating from a reference angle during the mass production with the automatic line, the wrong angle is corrected in use.

Abstract: A medicament delivery device configured to provide a variable single dose of medicament is disclosed. The medicament delivery device includes a main body and a syringe arranged in the main body, wherein the syringe comprises a medicament. The medicament delivery device further includes a removable cap and a plunger rod operatively arranged to eject the medicament through a delivery member i.e. an injection needle attached to the syringe. Still further, the medicament delivery device includes a tubular member coupled to the plunger rod. The tubular member is configured to rotate during removing of the removable cap, and the rotation releases the plunger rod thereby allowing the plunger rod to travel a predetermined distance so as to prime the medicament delivery device.

Abstract: A medicament delivery device is disclosed, comprising a cartridge assembly that comprises a cartridge having a medicament chamber for containing a medicament, a sealing element for sealing a distal end of the medicament chamber and a coupling element attached to the cartridge. The device also includes a sealing element release member, a cannula for delivery of the medicament, and a removable cap. The device is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. A proximal end of the release member is sealed in a release member chamber defined in part by, the sealing element and in part by the coupling element.

Abstract: A fluid delivery manifold system assembled and configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular manifold design consisting of separately constructed components cooperatively arranged and coupled to one another. The modular manifold construction allows for rapid manufacturing reconfigurations of one or more components with minimal costs to create new delivery manifold configurations that meet specific needs (i.e., different modes of delivery depending on agent to be delivered, such as subcutaneous, intramuscular, intradermal, intravenous injection, spray, or droplet delivery).

Abstract: The present invention relates to a medicament delivery device comprising a housing, arranged to accommodate a medicament container; a power unit arranged inside said housing, said power unit comprising a plunger rod, a drive spring operably arranged to act on the plunger rod and, which is, upon activation, operably arranged to act on said medicament container, an actuator comprising holding elements, capable of releasably holding said plunger rod with said drive spring in a tensioned state, and an actuator sleeve operably connected to said actuator for releasably locking said holding elements in a holding state; said medicament delivery device further comprising a medicament delivery member guard slidably movable in said housing and arranged to act on said actuator sleeve for setting said holding elements with said actuator sleeve in a first activation state; an activator unit arranged to be manually operated and, which is, operably connected to said plunger rod for setting said holding elements with said act

Abstract: An autoinjector device is provided. The autoinjector device can include an activator unit including an activation housing, an activation guard, and an activation shell such that a portion of the activation guard extends beyond a proximal end of the activation shell. The autoinjector device can include camouflage on a proximal surface to obscure a device lock hole and reduce user confusion around needle orientation.

Abstract: A pharmaceutical syringe unit is configured to be mounted to a pharmaceutical injection device main body and hold a pharmaceutical-filled pharmaceutical syringe, in order to mount the pharmaceutical syringe to a pharmaceutical injection device, wherein a syringe cover is configured to slide forward and backward with respect to a distal end cap by operation of the pharmaceutical injection device main body, thereby allowing movement between a needle insertion position at which insertion of an injection needle into a target is to be completed, and a needle withdrawal position at which withdrawal of the injection needle from the target is to be completed, and a guide component is configured to guide the syringe cover over a range that is greater than a distance between the needle insertion position and the needle withdrawal position.

Abstract: A device for delivery of a medicament from a container (10) having an outlet (16) at a distal end of the container (10) and a stopper (22) for containing the medicament in the container (10).

Abstract: A medicament delivery device is presented having a housing, a medicament container holder arranged to accommodate a medicament container provided with a medicament delivery member, a power unit arranged to act on the medicament container for expelling a dose of medicament when activated, an activation mechanism operably connected to the power unit. The activation mechanism is capable of activating said power unit and includes a medicament delivery member guard movable in a longitudinal direction in relation to the housing. The activation mechanism also has a force element arranged to bias said medicament delivery member guard to a proximal extended position wherein said medicament delivery member is covered and has a locking mechanism operably arranged to lock the medicament delivery member guard in the extended position, where the locking mechanism has a number of locking elements connected to the medicament delivery member guard and flexible in a generally radial direction.

Abstract: An autoinjector (100?) for expelling a single dose of a drug from a held cartridge (600) comprising a piston (630). The autoinjector includes a needle shield (350, 380?) axially movable from an initial extended position via a triggering position to a trigger release position. The needle shield (350, 380?) is operatively coupled to a plunger release element (320?, 1320) cooperating with a plunger (310, 400) to define a releasable retaining mechanism that retains the plunger release element (320?, 1320) threadedly engaged with a base thread component (204?, 1204) in a predefined relative rotational and axial position and against rotational bias provided by an actuator (330). The needle shield (350, 380?) is configured for operating the retaining mechanism to release the retaining of the plunger release element (320?, 1320) and the base thread component (204?, 1204) from the predefined relative rotational and axial position upon the needle shield (350, 380?) being moved into the trigger release position.

Abstract: A cartridge for delivery of a material therefrom which has a corrugated portion to allow for bending/extending to be applied to the device from which a material to be deposited can be dispensed. The bendability and extendibility allow for greater efficiency in use and application of the material into cavities, pockets, and/or crevices where one needs to deposit the material.

Abstract: The present invention relates to a process for lyophilising a product (3), comprising the steps of providing a bulk product (3) loading system in the form of a bag (1), the bag (1) having an interior and an exterior defined by a flexible wall, the bag (1) further comprising a filling port (5) providing access to the interior of the bag (1), filling a product (3) having a first moisture content into the interior of the bag (1) via the filling port (5), and exposing the product (3) in the interior of the bag (1) to a lyophilisation cycle such that the moisture content of the product (3) is reduced from the first moisture content to a second, lower, moisture content.

Abstract: Needle shield mechanism for an auto-injector comprising, a tubular housing (10), a needle shield (12) movably arranged in the housing (10), between a retracted state and an extended position, a releasable spring-biased container carrier assembly movably arranged relative to the housing (10) from an initial position to a penetrating position, wherein the container carrier assembly prevents the needle shield (12) from moving to the extended position when the container carrier assembly is in the initial position, and wherein the container carrier assembly allows the needle shield (12) to move to the extended position when the container carrier assembly is in the penetrating position.

Abstract: An auto-injector comprising an elongate housing containing a syringe. The housing having an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring pushing the needle from a covered position into an advanced position, operating the syringe and covering the needle. An activator arranged to lock the spring prior to manual operation and capable of, upon manual operation, releasing the spring means for injection. A first gear arrangement and a second gear arrangement arranged fro converting torque from a first end and a second end of the torsion spring into a translative force. The first end groundable in the housing while the second end acts on a plunger through the second gear arrangement for advancing the needle and supplying the dose.

Abstract: In a general aspect, a syringe terminates the dispensing of a fluid based on a force applied to a plunger member of the syringe. In some aspects, a plunger member of a syringe includes a top portion, a bottom portion, and a contact portion. The top and bottom portions are in contact with the contact portion, and the bottom portion has a length greater than or equal to a length of the top portion. The contact portion permits the top portion to move independent of the bottom portion in response to a stress in the contact portion exceeding a critical stress. The stress in the contact portion is based on a first force applied to the top portion and a second force opposite the first force applied to the bottom portion.

Abstract: A medicament delivery device configured to provide a variable single dose of medicament is disclosed. The medicament delivery device includes a main body and a syringe arranged in the main body, wherein the syringe comprises a medicament. The medicament delivery device further includes a removable cap and a plunger rod operatively arranged to eject the medicament through a delivery member i.e. an injection needle attached to the syringe. Still further, the medicament delivery device includes a tubular member coupled to the plunger rod. The tubular member is configured to rotate during removing of the removable cap, and the rotation releases the plunger rod thereby allowing the plunger rod to travel a predetermined distance so as to prime the medicament delivery device.

Abstract: With certain implementations, the configuration is such that a controller uses a first driver to move a pharmaceutical syringe attachment component closer to the distal end side than a needle removal position when a needle unit is attached to a pharmaceutical syringe unit or when the needle unit is removed from the pharmaceutical syringe unit, so when an injection needle is attached to the pharmaceutical syringe unit, or when the injection needle is removed from the pharmaceutical syringe unit, these operations can be executed without removing a distal end cap, which makes the device extremely convenient to use.

Abstract: The present invention relates to a torsion spring driven injection device for delivering set doses of a liquid drug. The injection device mechanism is encapsulated in a housing which also stores the cartridge containing the liquid drug. A needle cannula which is in liquid communication with the interior of the cartridge and which has a distal tip is shielded by a telescopically movable needle shield is used to inject the set dose. The needle cannula is preferably used for multiple injections and cleaned between subsequent injections. The drive mechanism further comprises a nut member engaging the piston rod and releasable coupled to the housing to operate as a pressure relief mechanism. The telescopically movable needle shield covering the distal tip of the needle cannula is formed to lock the nut member to the housing during injection.

Abstract: An autoinjector includes a case, a syringe carrier slidably disposed within the case and adapted to hold a syringe including a stopper, a plunger slidably disposed within the syringe carrier and adapted to apply a force on the stopper, and a drive spring disposed within the plunger and biasing the plunger relative to the syringe carrier.

Abstract: Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

Abstract: An autoinjector comprises a housing, a product container, a displaceable needle protection sleeve, a plunger rod displaceable by a preloaded discharge spring, a dose setting element with at least two different rotational positions relative to the housing, and a dosing sleeve. The dosing sleeve or the plunger rod has a dose selection stop, and the other has at least one dosing stop. By rotating the dose setting element, the dosing sleeve or the plunger rod is rotated relative to the other. Upon displacement of the needle protection sleeve, the spring displaces the plunger rod, whereby, if the dose setting element is in the first rotational position, the dose selection stop and the first dosing stop strikes against each other, and, if the dose setting element is in the second rotational position, one of the dose selection stop and the first dosing stop is or can be moved past the other.

Abstract: The present disclosure relates to a drug delivery device, comprising a housing, a cartridge, the cartridge containing a drug in a quantity sufficient for a plurality of doses of the drug, a bung, the bung being movably retained within the cartridge to dispense a dose of the drug from the cartridge upon movement of the bung with respect to the cartridge, and a drive mechanism, the drive mechanism being operable to transfer a driving force to the bung to dispense the dose of the drug from the cartridge. The drug delivery device is configured such that the maximal driving force which is transferrable to the bung via the drive mechanism varies and is adjusted to the current position of the bung within the cartridge.

Abstract: Container holder assembly for a medicament delivery device comprising a housing part 22, a container holder 50, and a spring-biased needle guard 82, wherein the needle guard 82 is configured to disconnect from the container holder 50 upon movement from the extended position to the retracted position.

Abstract: An autoinjector (100) for expelling a single dose of drug from a drug cartridge (600) including a piston (630), the autoinjector including: a base (200, 220), a needle (500) that is fixedly mounted relative to the base (200, 220), a plunger (310, 320, 400) adapted for cooperation with the piston (630), an actuating spring (330) provided as a helical compression spring arranged to act on the plunger (310, 320, 400) by exerting an axial force on the plunger to drive the piston (630) distally, and a needle shield (350, 380) axially movable relative to the base (200, 220) between an extended position and a collapsed position. The autoinjector defines a lock (320, 328, 380, 388) that is released when the needle shield (350, 380) is moved from the extended position to the collapsed position.

Abstract: The invention relates to a drive mechanism (9) for a needle insertion arrangement (1), the drive mechanism (9) including:—a cross beam (16) linearly movable in a distal direction (D) and a proximal direction (P) for moving an injection needle (2),—an actuator (5),—a slider (12) coupled to the actuator (5) and linearly movable in a transversal direction (T) at right angles relative the distal direction D and the proximal direction D,—a cam (14) on one of the cross beam (16) and the slider (12),—a guide track (13) in the other one of the cross beam (16) and the slider (12) adapted to engage the cam (14), the guide track including a sloped section (13.3) such that the cross beam (16) is moved on movement of the slider (12).

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: A power pack assembly for a medicament delivery device, the power pack comprising a plunger rod (64) extending along a longitudinal axis (L) and having a proximal and an opposite distal ends, an actuator (90) provided with a holding element (96) and configured to interact with a corresponding holding element on the plunger rod (64), a first force element (68) arranged to exert a force on the plunger rod; an actuator sleeve mechanism (119) arranged to releasably lock said holding element (96) in engagement with the corresponding holding element of said plunger rod (64) such as to hold said first force element (68) in a tensioned state.

Abstract: The present invention relates to an infusion device comprising a housing (10, 12); a compartment inside said housing for positioning a medicament container (78), an infusion needle (124) arranged to said housing, being connectable to said medicament container for delivering a dose of medicament, a piston plunger (72) arranged in said housing capable of acting on said medicament container for delivering a dose of medicament, mechanical drive means capable of acting on said piston plunger for delivering a dose of medicament. The invention is characterized in that said piston plunger comprises a number of distinct segments (82) being inter-connectable to each other for forming an elongated piston plunger.

Abstract: A medicament delivery device includes a housing arranged to accommodate a medicament container, and a drive unit operably arranged to act on an accommodated medicament container for expelling a dose of medicament. The drive unit includes a plunger rod, a force element operably connected to the plunger rod, a connector arranged to releasably hold the plunger rod, an actuator element operably arranged to the connector, and a manually operable actuator arranged to act on the actuator element for releasing the connector when operated. A safety device is arranged to releasably hold the actuator element in a locking position with the connector, preventing unintended release of the plunger rod.

Abstract: The present disclosure pertains to an assembly for a drug delivery device having a housing part, a piston rod displaceable relative to the housing part, a first sleeve member and a second sleeve member. First and second sleeve members are coupled to the housing part. In an initial state of the assembly the first sleeve member is movable from an initial position to a second position relative to the second sleeve member which allows the piston rod to axially travel from an initial position to a predetermined second position such that the assembly is in a primed state. Moreover, in the primed state of the assembly, with the first sleeve member being in the second position relative to the second sleeve member, first and second sleeve members are permanently rotationally and axially locked to each other by a first engagement feature such that first and second sleeve members together form a sleeve.

Abstract: An injection device having a distal end, and including a needle located inside the injection device in an initial position, wherein the needle is moveable to a puncturing position in which the needle projects from the distal end, an open region located distally relative to the needle in the initial position of the needle and having a dimension, a reduction piece moveable relative to the opening region whereby the dimension may be reduced and a holding member that latchingly connects to the reduction piece and a product container holder.

Abstract: An automatic applicator for liquid pharmaceutical preparations, particularly for multiple injection application of set doses of a medicine from an exchangeable container is provided. The automatic applicator includes a body housing connected to a housing of an exchangeable container with a medicine having a plunger, the said plunger being displaced only linearly by an integrated driving unit, suitable for immobilizing, driving, leading linearly and blocking rotation of the plunger, driven via a double action clutch, by a tensioning spring situated in the body housing, the spring tensioned by a rotary hand-dose-setting ring via the double action clutch, wherein the driving unit is activated by a trigger unit and a dose is indicated by an indicating arrangement. The automatic applicator further includes at least one block key placed in an upper part of a ratchet barrel, collaborating with at least one key placed in an internal part of the body housing.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: An injection device includes an elongate housing (10), a syringe (12) disposed in the housing, and an internal piston (20) to express a dose from a needle (16) at its front end. The injection device further includes a shroud element (24) movable forwardly relative to the syringe to shroud the needle after use and a latch (74) movable between a latched state in which it restricts rearward movement of the shroud element, and a release state. The latch is moved to its latch state by a magnetic force (56).

Abstract: A syringe assembly includes a syringe, a locking element and a protective sleeve. The syringe includes a needle connected to a cylinder. The protective sleeve is located on and around the cylinder and movable from a first position into a second position. The protective sleeve only covers the cylinder in the first position. The protective sleeve covers the needle in the second position. The locking element is adapted to keep the protective sleeve in the first position in a resilient manner. The locking element is further adapted to keep the protective sleeve in the second position. That is, after the protective sleeve is moved to the second position, return of the protective sleeve to the first position is prevented by the locking element.

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body for retaining the pre-filled syringe therein, a hollow needle shield and a spring means made from a resilient plastics material. The needle shield is telescoped with the support body and the spring means biases the needle shield in a distal direction.

Abstract: A needle assembly for an injection pen (22) has a sleeve (21) supporting internally a double-ended needle having an injection end and a non-injection end (25). The end of the sleeve surrounding the non-injection end (25) of the needle is divided into deformable segments (28) and is internally threaded for interengagement with a threaded boss (23) of the injection pen (22). A collar (29) is mounted on the sleeve (21) for sliding movement between a first position where the collar (29) overlies the segmented end and maintains interengagement of the threads at that end with those of the injection pen boss (23) and a second position where the segments may expand radially to come free of the injection pen boss (23). The needle may be mounted on a carrier (68) slidable with respect to the sleeve (21), the carrier (68) being coupled to the sleeve (21) for movement thereby.

Abstract: A method is disclosed for the collection of performance metrics by establishing service operations administration and maintenance (OAM) sessions between an actuator and a plurality of reflectors in a communication network. Test packets from an actuator simultaneously reach a plurality of reflectors along a test path. Each single test packet results into a plurality of test results, one per reflector, with quasi-synchronous performance metrics to sectionalize a network and more efficiently isolate fault or performance problems without the need for additional test packets to isolate the issue. Another method is disclosed wherein an actuator generates and transmits a plurality of simultaneous test packets, one per NID device, resulting into a plurality of test results, one per reflector, with quasi-synchronous performance metrics to sectionalize a network and more efficiently isolate fault or performance problems without the need for additional test packets to isolate the issue.

Abstract: The invention relates to a safe support device for a syringe, said support comprising a support sheath for the body of a syringe, and safety means which comprise an inner sheath suitable for sliding relative to said support sheath between a waiting retracted position, in which said inner sheath is substantially retracted inside said support sheath, and an active protection position, in which said inner sheath projects from said support sheath. The inner sheath has a free end portion formed by a flexible end-piece. The invention also relates to an assembly comprising such a safe support device and a syringe having a body, a piston and a needle disposed at one end of said body.

Abstract: An instrument for inserting a suppository including a tube, having a first end adapted to receive the suppository and a second end, a plunger disposed in the tube and moveable therein to eject the suppository from the first end by causing an action of pushing the suppository from behind. Retaining tongues are splayed outwards for ejection of the suppository in response to movement of the plunger in the tube, via contacting cooperation between at least one part of the plunger and at least one part of the tube. Securement mechanism secure the plunger in the tube at first position in which the suppository is retained in the first end of the tube, while allowing a user to move the plunger to actuate the instrument, and to secure the plunger in the tube at a second position which is only achievable after the plunger has been moved to eject the suppository.

Abstract: The invention provides a description of a method and a device suitable for producing a cell suspension spray with living cells, and the produced cell preparation, suitable for grafting to a patient. In contrast to other methods, the spraying is performed through a disposable needle which is inserted into a disposable air tube; which provides a cell distribution avoiding spray nozzles. Small suspension droplets are provided instead of cell nebulization. By using medical grade sterile Luer-lock disposables from medical routine praxis, biocompatibility and easy application is addressed. In applying the method and/or in using the device, cells suitable for grafting to a patient are dispersed in a solution and sprayed with the device for distribution over the recipient graft site.

Abstract: The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component within a housing, the shuttering mechanism comprising at least one fixed shutter attached to or integrated with the housing and at least one moving shutter arm moveable between at least one locking position and at least one unlocking position, wherein at least one resilient arm is associated with the longitudinally moveable component, the resilient arm having a dog resiliently biased towards the fixed shutter, wherein the moving shutter arm is arranged alongside the fixed shutter, wherein at least one fixed protrusion is arranged on the fixed shutter at least one of them arranged for engaging the dog so as to prevent translation of the longitudinally moveable component in a proximal direction, wherein at least one moving protrusion is arranged on the moving shutter arm, at least one of them ramped in a manner to disengage the dog from the at least one of the fixed protrusions and/or to prevent eng

Abstract: According to the invention, a safety device for a pre-filled syringe with an injection needle comprises of a support body adapted to mount the pre-filled syringe, a needle shield slidably arranged with respect to the support body, a retention and locking means (M) for retaining and locking the needle shield with respect to the support body in a first and a second advanced position (PA1, PA2) and in a retracted position (PR). The needle shield comprises an annular flange adapted to rest on the skin of the patient receiving an injection. The retention and locking means (M) are arranged at a distal end of the safety device.

Abstract: The invention relates to a detent mechanism for controlling translation between two components in a longitudinal direction, the detent mechanism comprising a resilient beam on one of the components and a rhomboid ramp member on the other component, the resilient beam being essentially straight when relaxed and having a first beam head and arranged to interact in a ramped engagement with respectively one of two ramps, each ramp on one longitudinal side of the rhomboid ramp member in such a manner that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction when a predetermined value of the translative force, at least depending on the resilience of the resilient beam, is overcome so as to allow the first beam head to travel along one transversal side of the rhomboid ramp member on continued relative translation of the components, wherein the resilient bea

Abstract: An apparatus for removing a sheath from a syringe. The sheath provides a sterile cover for a needle of the syringe. The apparatus includes a substantially cylindrical housing defining an opening for receiving a sheath attached to a syringe, and a driver mounted on the housing and being slideable along the housing between first and second axially displaced positions. The apparatus further includes a plurality of radially deflectable fingers mounted within the housing and being coupled to the driver for movement therewith. The fingers are configured such that movement of the driver from the first to the second position causes the fingers to slide over the sheath and engage with a formation on the sheath. Movement of the driver from the second position towards the first position causes the fingers to push the sheath off the syringe. Also provided is an injection device including the apparatus.

Abstract: An apparatus includes a housing, a medicament container and a movable member. The medicament container is configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member is configured to exert the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member is configured to exert a retraction force on the flange to move the medicament container from the second position towards the first position.

Abstract: A safety device for a pre-filled syringe comprises a hollow support body to retain the pre-filled syringe, a retaining collar and a rotating collar arranged within the support body. The retaining collar is releasably mounted to the support body. The rotating collar is slidable along an axial length of the support body and rotatable around a central axis of the safety device. The retaining collar is movable with respect to the support body in a proximal direction when the retaining collar is released from being mounted to the support body by the rotating collar.

Abstract: The invention relates to a coupling system that can particularly be applied for interfacing a consumable component with a sample chamber to a laboratory instrument for processing a sample fluid. The coupling system comprises a female interface module (10) integrated into the consumable component that has an elastic sealing component (12) with a preformed channel (12a). Moreover, it comprises a male interface module (20) integrated into the instrument and comprising a hollow needle (23) fixed in a first section (22a) of a bush (22), wherein the flexible free end of said needle (23) is partially surrounded by a second section (22b) of the bush that limits the lateral movement of the needle. The diameter of the channel in the sealing component (12) is preferably smaller than the diameter (d) of the needle (23), thus providing an airtight connection and a self-cleaning effect.

Abstract: A medicament delivery device comprising a housing, a tubular activation member, a first resilient member, a container holder, a medicament container (80), a tubular operation member (100), a plunger rod (90), a delivery member; wherein the container is a cartridge, having a membrane (82) and in that the delivery member comprises a retainer member (70) fixedly connected to the container holder, a hub (60) coaxially movable within the retainer member, a needle having opposite proximal and distal ends, and a cap (10) interactively connected to the hub and to the retainer member, wherein the cap comprises a distal end surface abutting with the proximal end surface of the annular contact member such that said hub may be distally moved whereby the needle penetrates the membrane and the cap is detached from the retainer member, allowing the tubular activation member to be moved its activated position.