Abstract: Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes fluid pathways controllable by valves of the cartridge. A pump component within the cartridge is actuable to move fluid through the controllable fluid pathways. The cartridge includes a needle extending from a cartridge body and fluidly coupled to at least one of the controllable fluid pathways. The cartridge includes a vacuum bellows that surrounds the needle when the bellows is in an extended configuration. The vacuum bellows is compressible to expose the needle and generates a vacuum condition within the bellows when the bellows is extended from a compressed configuration to the extended configuration. The needle may be a dual-lumen plastic needle.

Abstract: Described herein are syringe caps including a plug portion and a protruding member extending from one end of the plug portion. The protruding member can extend a length greater than a depth of an accumulated component in the syringe. Also described herein, are systems including a syringe containing a composition and a syringe cap. The syringe cap can include a luer-lock with a projecting member that projects into the syringe. The projecting member can assist in creating a tunnel through the accumulated material thereby allowing degassing of the composition. The projecting member can also help to prevent accumulation of a radiopaque visualization agent or contrast agent that may accumulate along one end of the syringe.

Abstract: A masking package (100) for blind testing of materials stored in a syringe, the masking package (100) comprising: an opaque housing (110) defining a syringe chamber (111) adapted to substantially surround a plunger and at least a portion of a barrel of a syringe; and a plunger extender (130) slidably receivable in the syringe chamber (111) and comprising a coupler (132) adapted to couple to the plunger of a syringe received in the syringe chamber (111), wherein movement of the plunger extender (130) relative to the opaque housing (110) moves the plunger of a syringe received in the syringe chamber (111) relative to the barrel of the syringe; and a masking package (200) for blind testing of materials stored in a vial, the masking package (200) comprising an opaque housing (210) defining a chamber (211) for receiving and surrounding a vial, the housing (210) having a length between an upper end and a lower end and comprising a first housing part (212) and a second housing part (214), the first and second housin

Abstract: Described is a dose tracking mechanism for a drug delivery device, including a moveable component configured to move with respect to a housing during operation of the drug delivery device and an RFID device with an electric circuit having a resonance frequency. The electric circuit includes an antenna configured to transmit a wireless RFID signal at the resonance frequency and an electrical component operatively coupled to the moveable component and configured to modify the resonance frequency based on a position of the moveable component, such that the resonance frequency of the electric circuit is an indication of the position of the moveable component. In some instances, the position of the moveable component indicates a dose set or dispensed from the drug delivery device.

Abstract: A pre-Tillable or prefilled container for at least one of storage or application of a fluid includes: a receptacle having a chamber for accommodation of the fluid; a cannula assembly including a cannula and a sealing element, the cannula having an outside channel opening, the cannula assembly being attachable to the receptacle; and a closure cap including a sealing. The channel opening of the cannula protrudes into the sealing of the closure cap thus sealing the channel opening. Due to at least one of a radial compression or an axial compression of the sealing element, as well as due to sealing of the channel opening by the closure cap, the chamber is sealed in a fluid-tight manner.

Abstract: A syringe (18) has a longitudinal body (28) with an interior (228) in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body (228) and a rigid needle shield (38) encasing the needle. The rigid needle shield (38) is essentially water vapour tight. The syringe (18) according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.

Abstract: Implementations of the present disclosure are directed to an injection device including: a reservoir including a wall defining a proximal end, a distal end and a tubular side, a plunger rod configured to be movable within the reservoir in a direction from the distal end to the proximal end, a radio frequency (RF) antenna attached to the tubular side and configured to receive an interrogation signal from an external device, and a resonating assembly configured to receive the interrogation signal from the RF antenna and to generate a modulated RF signal having a frequency associated with a position of the plunger rod.

Abstract: A food ingredient transfer device is provided. The food ingredient transfer device includes a dosing device configured to receive a food ingredient, and a first chamber that is provided with an inlet and an outlet for allowing the dosing device to pass through the first chamber. The food ingredient transfer device further includes a second chamber arranged adjacent to the first chamber for receiving the dosing device when it has passed through the first chamber, the second chamber being provided with an outlet for allowing the dosing device to pass through the second chamber and into an enclosure that contains a food product to which the food ingredient shall be transferred.

Abstract: In a syringe, which is a prefilled syringe, when a cap body is attached to a cylindrical portion, a first sealing section is compressed radially inward by an inner peripheral surface constituting an opening of the cylindrical portion, thereby sealing a distal end section of a flow path in a liquid-tight manner, and a second sealing section is compressed radially inward by an inner peripheral surface of a proximal end section of the cylindrical portion, thereby sealing a proximal end section of the flow path in a liquid-tight manner.

Abstract: A piston to be provided within an inner wall of a barrel of a pharmaceutical syringe for dispensing medicament retained in the barrel is described. The piston includes a body defining a central face, a cylindrical portion, and an annular curved portion between the cylindrical portion and the central face portion. The piston also includes an inert film enclosing the central face portion and at least a part of the annular curved portion. The cylindrical portion and the part of the annular curved portion are together configured to maintain a fluid-tight seal with the inner wall of the barrel. A pharmaceutical syringe is described for dispensing a medicament includes a barrel configured to retain the medicament and the piston.

Abstract: A needle assembly includes a catheter hub, a catheter tube extending distally from the catheter hub, and a needle hub having a needle having a needle tip extending out the catheter tube. A protective cap is positioned with the catheter hub and covers the catheter tube and the needle tip. The protective cap has a casing having a casing body, a first opening at a proximal end of the casing body, a proximal cavity having the needle tip and the catheter tube located in the proximal cavity, a second opening at an end opposite the first opening and opening into a distal cavity, and a rim at the second opening. A lid is removably attached to the rim at the second opening to seal a solution inside the distal cavity. The solution is dispensable from the distal cavity following separation of the lid from the rim.

Abstract: An infusion base for attachment to a user of an infusion set comprises an adapter having a lower portion, an inner wall portion, and a gap between the lower portion and the inner wall portion. At least one of the lower portion and the inner wall portion is configured to receive an attachment.

Abstract: Syringe assemblies comprising a first cap and a second cap to ensure sterilization of the fluid path without the need for external packaging are described. Also described are methods of sterilizing the fluid path of a syringe assembly.

Abstract: A protective cap having a first cap and a second cap that are removably coupled together for use in short-term and long-term antimicrobial treatment of needleless connectors and access ports of an infusion system. The instant invention further provides a protective cap having a first cap and a second cap that each coupled to a different surface of a component of an infusion system, such as a syringe. The instant invention further provides a strip containing a plurality of disposable protective caps.

Abstract: An assembly includes a sealed drug reservoir unit, a subcutaneous flow conducting device in the form of a needle unit or an infusion set, and a flow communication unit. The flow communication unit includes a proximal hollow needle adapted to penetrate a needle-penetrable septum of the reservoir, a first flow-way inflow communication with the proximal needle and comprising a pressure-controlled valve, a second flow-way in flow communication with the first flow-way, an amount of preservative arranged to react with a substance received by the second flow-way, and distal flow communication structure adapted to provide flow communication between the second flow-way and the needle unit. The valve is controlled to open when the reservoir is pressurized, the preservative being provided to react with substances introduced to the second flow way via the needle unit.

Abstract: An ISO 80369-3 compatible coupling having at least one vent, recessed groove, non-cylindrical geometry and/or textured surface formed therewith. According to one example embodiment, a vent can be formed on a male coupling and/or a female coupling. The vent can be in the form of recessed channel. According to one example embodiment, the coupling comprises non-cylindrical geometry such that at least one vent is provided.

Abstract: In order to provide a piston and a syringe with good sliding performance and pressure resistance performance, the piston contained in the syringe that pressurizes or decompresses an internal medium is configured such that a soft portion made of a soft material and a rigid portion made of a material having rigidity higher than rigidity of the soft portion, are connected in series, and arranged such that the soft portion is in contact with the medium and the rigid portion is not in contact with the medium. The soft portion includes a hollow on a surface in contact with the medium. The rigid portion has an end surface facing the soft portion, the end surface including at least an outer peripheral portion in contact with the soft portion. The outer diameter of the soft portion is larger than the outer diameter of the rigid portion, and the outer diameter of the rigid portion is slightly smaller than the inner diameter of an outer cylinder of the syringe.

Abstract: Devices and methods for sanitizing injection ports on intravenous, intramuscular and subcutaneous injection ports.

Abstract: An expanding plunger rod (100) for a syringe (50). The expanding plunger rod is configured to transition from a packaged configuration for packaging to an expanded configuration for operation. The expanding plunger rod comprises a substantially cylindrical outer sleeve (110) having a closed-off bottom end (108) and an open upper end (111). The expanding plunger includes an inner rod (114) having a lower end (138) and an upper end (140). The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod is configured to lock axially in place so as to prevent transition from the expanded configuration to the packaged configuration.

Abstract: Described are applicators having a plunger with a plunger body, and a tube having a receptacle end for insertion of the plunger, and a connector end formed of flexible plastic material having a bull-nose shape. As an example, the plunger body can include a viewing window. As another example, the connector end has an internal surface that is free of threaded connectors. The connector end can also have a snap-fit coupling design to couple to a snap-fit nozzle. The snap-fit nozzle can be connected to an adaptor cap or an administering tool of a metering dispenser.

Abstract: A device for automatically disinfecting a portion of a medical implement. The device includes a reservoir chamber having a top external opening, a medical implement protruded through a bottom part of the reservoir chamber with the portion to be disinfected exposed inside the reservoir chamber and below the top external opening, two disinfecting pads, and a resilient device. Each disinfecting pad is connected to the reservoir chamber through a mounting member, which permits displacement of the disinfecting pads relative to the reservoir chamber in substantially opposite directions thereby creating a gap between each pad and the portion to be disinfected. The resilient device biases the disinfecting pads such that when the disinfecting pads are displaced from a rest position, wherein they are contacting the portion to be disinfected, to an engaged position, the disinfecting pads are urged to return toward the portion to be disinfected to contact and disinfect the portion.

Abstract: Devices having male connectors for preventing connection to non-compatible female connectors are described. An exemplary male connector includes an elongate tip and a collar disposed coaxially around the elongate tip including a plurality of ribs disposed on either an inside surface or an outside surface of the collar for preventing entry of a non-compatible female connector into a channel formed between the elongate tip and the collar. One or more embodiments pertain to a device with a male connector and a compatible female connector including a threaded portion for engaging a corresponding threaded portion of the male connector.

Abstract: Described is a catheter patency maintenance device comprising of a flush syringe, an elongate plunger rod with a stopper slidably positioned within the barrel, a cap, disinfectant and a valve movable between an open position and a closed position. The valve may include a valve stem and/or openings in the valve to permit fluid flow. Methods of using the flush syringe assemblies are also described.

Abstract: The present invention relates to a ready-to-administer parenteral dosage form of norepinephrine which comprises an aqueous solution of norepinephrine, having an anti-oxidant which is not a sulfite anti-oxidant, wherein the dosage form is stable at room temperature for prolonged period of time.

Abstract: The present invention relates to an injection needle assembly having opposite distal and proximal ends, and wherein the assembly comprises an injection needle having proximal and distal pointed ends, wherein the distal pointed end is arranged to penetrate a membrane arranged at the proximal end of a medicament container; a tubular needle holder comprising distal engagement means and proximal engagement means; a tubular cap comprising proximal outer engagement means and proximal inner engagement means; a tubular needle cover comprising first engagement means arranged to cooperate with the proximal engagement means, and second engagement means arranged to cooperate with the proximal outer engagement means of the cap; characterized in that said needle cover is arranged to be displaced from a first position wherein the second engagement means and the proximal outer engagement means prevents the needle cover and the needle holder to be axially displaced by a linear displacement, to a second position wherein the ne

Abstract: A syringe or carpule includes a cylinder that surrounds a cavity and comprises an end that has an access to the cavity, membrane seals the access and has a puncture area that can be punctured by a needle. A two-part cap has a predetermined breaking line and spans the membrane. A cover device covers the puncture area of the membrane in a sterile manner and comprises a sealing area spanning the puncture area. The sealing area covers the puncture area in a sterile manner regardless of axial forces to be applied in the area of the predetermined breaking line.

Abstract: A method provides for procuring platelet rich plasma (PRP) from a sample of whole blood in a vial. The method includes the steps of: separating the whole blood into layers through centrifugation with an upper layer containing platelet poor plasma (PPP) and a PRP layer below the upper layer containing PRP; adjusting an end point of a first range of motion of an extractor relative to a position of the PRP layer; moving the extractor through the first range of motion through the vial, PPP passing out from the upper layer through the extractor; and after the extractor reaches the end point of the first range of motion, extracting the PRP through the extractor and collecting the PRP.

Abstract: A device for serving and preserving food items, the device including an open container for holding the food items having one or more side walls and a floor, wherein when the food items are immersed in fluid, typically a preserving fluid, the device is in a preserving state; a liquid-holding compartment, having a tubular form, for holding the fluid when the device is in a serving state; and a liquid-transfer mechanism for transferring the preserving fluid from the open container into the liquid-holding compartment and back. One or more passageways, interconnecting the open container and the liquid-holding compartment, facilitate the transfer of fluid between the open container and the liquid-holding compartment.

Abstract: An assembly includes a pre-filled syringe including a barrel with a first end and a second, open end, a plunger disposed within the barrel and spaced between the first end and the second, open end, a product disposed in the barrel between the first end of the barrel and the plunger, and an outwardly-directed rim disposed about the barrel at the second, open end. In addition, the assembly includes an identification tag secured to the outwardly-directed rim of the barrel of the syringe with an outwardly-facing surface of the tag overlying the second, open end of the barrel, the tag having an identifier disposed on the surface of the tag, the identifier including data regarding the pre-filled syringe, the product disposed in the barrel, or both.

Abstract: Methods and apparatus for employing an adhesive strap about a medical connection for improving connection integrity for greater safety and reliability and a cross contamination barrier for medical syringes is disclosed. Also, a shielding tube for a medical syringe which acts as a barrier against cross contamination across a syringe plunger is disclosed. The tube comprises a pattern of raised ribs inside to protect against potentially tube tearing edges of an associated plunger rod assembly and to provide a skid resistant surface when disposed about flanges of the syringe.

Abstract: A method for sterilizing an implantable sensor for sensing an analyte in a body tissue. The implantable sensor has a sensor part which can be introduced into the body tissue, at least one sensor electrode for sensing the analyte, and at least one electronics part. The electronics part has at least one electronic component and is connected to the sensor part. The method includes (a) introducing the implantable sensor into a package, the package sealing the implantable sensor from bacteria and accommodating a radiation shield, (b) irradiating the implantable sensor in the package with sterilizing radiation from at least one irradiating direction, in particular with electron radiation, the radiation shield shielding the electronic component of the electronics part from the sterilizing radiation, the radiation shield being arranged in such a way that the sensor part is sterilized by the sterilizing radiation.

Abstract: A safety syringe may define a variable fluid chamber and detached needle assembly. The variable fluid chamber may be hermetically sealed off from the environment or ambient air until the needle assembly is attached to a syringe body of the safety syringe. A proximal end of the variable fluid chamber is sealed off from the environment via a seal between a piston and syringe body. The distal end of the variable fluid chamber may be sealed off from the environment via a barrier covering the distal end of the syringe body. The barrier may be punctured to allow fluid to through tberethrough at or about the same time when the needle assembly is attached to the distal end portion of the syringe body.

Abstract: In accordance with at least one exemplary embodiment, a syringe device, a method and a system for delivering a therapeutic amount of ozone are disclosed. A sterility case can enclose a syringe portion and can maintain sterility while the syringe device is interfaced to an ozone generator. A valvably-controlled fluid channel can extend from a barrel of the syringe portion through the case. Conducting elements can be attached to the case and can breach the case. The conductive elements can be connected to electrodes. The electrodes can be attached to the syringe portion. The syringe portion can be filled with oxygen gas via the valvably-controlled fluid channel. An electric current can be provided to the conductive elements from the ozone generator resulting in a corona discharge from at least one of the electrodes. The therapeutic amount of ozone can be produced from the oxygen gas and the syringe portion delivered into a sterile field without compromise.

Abstract: A needle and receiver assembly for use with a syringe cartridge filled with medicine includes a cartridge receiver having a hollow interior, an open end sized for receiving at least part of the syringe cartridge, and a closed end opposite the open end. The assembly includes a needle mounted on the receiver having a fluid passage extending between a sharp delivery tip at a distal end of the needle and a sharp access tip at a proximal end of the needle opposite the delivery tip positioned inside the hollow interior of the receiver. The assembly includes a cutter movably mounted in the hollow interior of the receiver for cutting the diaphragm of the cartridge when received in the hollow interior of the receiver.

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger.

Abstract: Provided is a novel oxygen-absorbing resin composition having excellent oxygen-absorbing performance and suppressing odor generation after absorption of oxygen even if a material responsive to a metal detector is not used. Further provided is an oxygen-absorbing resin composition having excellent oxygen-absorbing performance in a wide range of humidity conditions from low humidity to high humidity. Such an oxygen-absorbing resin composition contains a copolymerized polyolefin compound and a transition metal catalyst, in which the copolymerized polyolefin compound contains at least one constituent unit having a tetralin ring.

Abstract: A safety syringe may define a variable fluid chamber and detached needle assembly. The variable fluid chamber may be hermetically sealed off from the environment or ambient air until the needle assembly is attached to a syringe body of the safety syringe. A proximal end of the variable fluid chamber is sealed off from the environment via a seal between a piston and syringe body. The distal end of the variable fluid chamber may be sealed off from the environment via a barrier covering the distal end of the syringe body. The barrier may be punctured to allow fluid to through therethrough at or about the same time when the needle assembly is attached to the distal end portion of the syringe body.

Abstract: A protective cap having a first cap and a second cap that are removably coupled together for use in short-term and long-term antimicrobial treatment of needleless connectors and access ports of an infusion system. The instant invention further provides a protective cap having a first cap and a second cap that each coupled to a different surface of a component of an infusion system, such as a syringe. The instant invention further provides a strip containing a plurality of disposable protective caps.

Abstract: Syringe assemblies comprising a disinfecting reservoir collar to ensure adherence to aseptic techniques for use in flush procedures for vascular access devices (VAD's) are described. The syringe assemblies include a plunger rod, a syringe barrel, and reservoir collar that permits disinfection of a hub of a VAD connector upon connection to the reservoir collar. Also described are methods of disinfecting vascular access devices.

Abstract: Embodiments of the invention are directed to flush syringe assemblies comprising an integrated contamination-prevention device integrated with device connector flushing positioned so that the practitioner cannot forget to apply disinfectant. The flush syringe assemblies comprise a barrel with an elongate plunger rod disposed therein and a cap comprising a passageway. The plunger rod includes a stopper of which at least a portion can be embedded in the passageway of the cap to form a plug in the cap.

Abstract: A hinged cap device for use with a syringe includes a base defining an interior cavity for mounting onto a tip and a cap connected to the base by a living hinge. The cap is moveable from a ready position to an open position to expose a needle, and from the open position to a secured position to prevent relative rotation between the cap and the base. A first latching mechanism is on the cap for engaging the needle, the first latching mechanism locatable on a first side of the needle in the ready position and locatable on a second side of the needle in the secured position. The needle is disengageable from the first latching mechanism in the ready position, and the needle is not disengageable from the first latching mechanism in the secured position.

Abstract: An injection needle assembly is presented having a tubular needle holder with distal and proximal engagement means, a tubular cap having proximal inner and outer engagement means, a tubular needle cover having a first engagement means arranged to cooperate with the proximal engagement means, and second engagement means arranged to cooperate with the proximal outer engagement means of the cap. The needle cover is arranged to be displaced from a first position wherein the second engagement means and the proximal outer engagement means prevents the needle cover and the needle holder to be axially displaced by a linear displacement, to a second position wherein the needle cover and the needle holder are distally displaced. The proximal inner engagement means of the cap and the distal engagement means of the needle holder prevents the needle holder to be proximally displaced but allows the needle cover to be distally displaced.

Abstract: Methods and apparatus for employing an adhesive strap about a medical connection for improving connection integrity for greater safety and reliability and a cross contamination barrier for medical syringes is disclosed. Also, a shielding tube for a medical syringe which acts as a barrier against cross contamination across a syringe plunger is disclosed. The tube comprises a pattern of raised ribs inside to protect against potentially tube tearing edges of an associated plunger rod assembly and to provide a skid resistant surface when disposed about flanges of the syringe.

Abstract: The invention relates to a syringe (20) comprising a syringe barrel (15), an ejector unit (25) arranged at the distal end of the syringe barrel (15) with a plunger rod (17), a coupling part (37) and a plunger (16) and a syringe head (21) arranged at the proximal end of the syringe barrel (15) with a needle unit (12) which is arranged in a guide sleeve (5) and is slidable therein with a cannula (3) and a cannula holder (4) and a pinion (2), by means of which the needle unit (12) is axially movable, relative to a syringe barrel (15) from a rest position to an actuation position. At the distal end of the guide sleeve (5) a sealing element (7) is arranged. The pinion (2) has at least one guide knob (1), which can be brought into engagement optionally with one of two slide tracks (10) provided in the guide sleeve (5), wherein the slide tracks (10) are inclined in opposite directions.

Abstract: Described is a catheter patency maintenance device comprising of a flush syringe, an elongate plunger rod with a stopper slidably positioned within the barrel, a cap, disinfectant and a valve movable between an open position and a closed position. The valve may include a valve stem and/or openings in the valve to permit fluid flow. Methods of using the flush syringe assemblies are also described.

Abstract: Disclosed herein are disinfecting caps that can be used to cover and disinfect a male luer post of a medical connector. The caps are configured to engage threads of the connector. The caps contain a disinfecting agent within an absorbent pad disposed in a chamber of the cap.

Abstract: Disclosed herein are disinfecting caps that can be used to cover and disinfect a male luer post of a medical connector when not in use or when disconnected from its female connector counterpart. The caps are configured to engage threads of the connector. The caps contain a disinfecting agent disposed in a chamber of the cap.

Abstract: Syringe assemblies comprising a first cap and a second cap to ensure sterilization of the fluid path without the need for external packaging are described. Also described are methods of sterilizing the fluid path of a syringe assembly.

Abstract: A sterilization cap carried on a needle support end of a syringe. The cap includes a main body having first and second ends, the first end being connectable to the needle support end, as well as being connectable onto the needle support end alone of a primary or IV extension line. A sponge secured within a sponge cavity within the second end is saturated with a sterilizing liquid. A removable cover attached to the second sealingly encloses the sponge until the syringe is used. The second end is sized, when the cover is removed, to fit over a tip of a CLAVE needleless connector extension or IV tubing a distance sufficient to compress the sponge to sterilize the tip with sterilizing liquid expressed from the sponge.

Abstract: A gas-impervious container having a gas-permeable porous insert, wherein the insert contacts a flowable biomedical material, for improving access of the sterilant gas to the material.