Abstract: One aspect relates to a method for providing a bone cement from two starting components, having a hollow cylinder-shaped first container, in which a monomer liquid as first starting component can be stored, a hollow cylinder-shaped second container comprising a container wall, a first internal space, and a second internal space, whereby a bone cement powder as second starting component can be stored in the first internal space, and whereby the monomer liquid can be conveyed into the second internal space, a fluid-conducting conveying means arranged between the first internal space and the second internal space, whereby the first container and the second container are axially connected to each other.

Abstract: The claimed subject matter comprises a device to collect and preserve cells comprising of: (1) a collection container comprised of a tube having an open end and a closed end, a closure in the open end of the tube, a vacuum drawn to a predetermined level inside the container; and (2) compounds including an anticoagulant agent and a fixative agent, wherein the compounds are in a sufficient amount to preserve said cells” original morphology and antigenic sites without significant dilution of said cells, and thereby allowing said cells to be directly analyzed by a flow cytometer without further treatment.

Abstract: An assembly machine for assembling a rigid needle guard (10) having an inner part (11) made of elastomeric material, and a rigid outer body (12) that is fastened to the inner part (11) made of elastomeric material via a folded-in portion (121) of the bottom axial end of the rigid outer body (12). The folded-in portion (121) extends radially inwards from the outer peripheral surface (125) of the rigid outer body (12), the outer surface of the folded-in portion (121) forming, at its axially-bottom and radially-outer edge, a sharp and acute angle relative to the outer peripheral surface (125) of the rigid outer body (12).

Abstract: The invention relates to a glass syringe-side assembly element for providing an interface element between a glass syringe including on its front side a syringe cone part with a syringe needle and including on its rear side a flange part and a glass syringe operating means, where the assembly element can be arranged on the outer contour of the glass syringe, and where the assembly element can be secured to the assembly element relative to the syringe needle in front of the flange part on the glass syringe such that a reference point of the assembly element is always at a defined distance from the needle tip of the syringe needle.

Abstract: A medicament container holder for securing a medicament container having a generally tubular body arranged with a proximally directed neck portion and a flange portion arranged with a pierceable septum. The medicament container holder has mechanical holding elements that interact with the flange portion for preventing movement of the medicament container in a distal direction and having mechanical fixation elements configured to interact with the flange portion for urging the flange portion in the distal direction against the holding elements, where the medicament container holder has attachment elements for a medicament delivery member. The mechanical fixation elements are configured to engage with the medicament delivery member when attached to the attachment elements, such as to exert a force in the distal direction on said flange portion.

Abstract: An inhaler system suitable for providing nicotine particles includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion includes a capsule cavity and a mouthpiece air channel extending from the mouthpiece end to the capsule cavity. The distal end portion includes a piercing element coupled to the distal end portion and a resealable membrane configured to seal the capsule cavity when the mouthpiece portion is coupled to the distal end portion. The resealable membrane is configured to reseal when the piercing element moves out of the resealable membrane.

Abstract: An injector for delivering a medicament includes an outer sleeve, an inner sleeve, and a syringe. The inner sleeve is disposed partially within the outer sleeve. A plunger rod of the syringe is engaged with the outer sleeve in a fixed spatial relationship such that the plunger rod and the outer sleeve translate as a unit. The outer sleeve is configured for axial translation relative to the inner sleeve from a first configuration wherein the inner sleeve extends from the outer sleeve a first distance to a second configuration in which the inner sleeve extends from the outer sleeve a second distance that is less than the first distance. Further, in a third configuration the inner sleeve extends from the outer sleeve a third distance that is greater than the second distance and the inner sleeve is restricted from axially translating with respect to the outer sleeve.

Abstract: A medical valve which is able to more reliably support an outer peripheral part of an elastic valve body with respect to a housing, and prevent a problem of the elastic valve body becoming dislodged inward. A medical valve includes an elastic valve body with annular grooves formed thereon and a tubular support part formed at an outer peripheral side of an annular joining part positioned between the annular grooves. Inside and outside holding parts engage the annular grooves provided to the valve inside and outside surfaces of the annular joining part. The outside holding part and inside holding part are provided to an opening member, and with the tubular support part, a part projecting inward in an axial direction is sandwiched and supported between the inside holding part and outside holding part.

Abstract: A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.

Abstract: A coded cartridge holder for use with a drug delivery device is provided. The cartridge holder includes a fastener that becomes operative based in part on a length of a cartridge or a diameter of the cartridge. In one embodiment, the cartridge holder is coupled to the drug delivery device. The cartridge holder comprises a first blocking feature. The drug delivery device includes a cartridge detector comprising a second blocking feature. This feature may be a pin, for engagement with the first blocking feature of the cartridge holder when the cartridge acts on the cartridge detector. The cartridge holder may further include a fastening mechanism configured to fasten the cartridge holder to the drug delivery device only when the second blocking feature engages the first blocking feature.

Abstract: A system and method is provided for an injectable substance delivery pen comprising a microneedle hub assembly removably engaged with a pen device body which includes a cartridge, a plunger, and a drive mechanism. The hub assembly includes at least one microneedle for intradermal or shallow subcutaneous injection of the contents of the cartridge. The cartridge, plunger and drive mechanism components of the pen body are fabricated of non-compliant and non-compressible materials to allow effective communication of the cartridge contents via the microneedle patient interface.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: An apparatus for transdermal injection includes a collet configured to transition between first and second states. In the first state, the collet receives a cartridge with a predetermined elongate shape. In the second state, an inner surface of the collet substantially conforms to the predetermined elongate shape of the cartridge such that expansion of the cartridge, when the cartridge is pressurized, is substantially uniformly opposed.

Abstract: An alignment assembly for a cartridge interface of a drug delivery device is disclosed. The assembly optionally includes a coupling for opening fluid communication between the cartridge and the delivery device. For example, the coupling optionally includes a cannula insertable through a septum of the cartridge. The assembly may include a guide for positioning the cartridge and/or an access channel thereof within a first precision of a loaded position. The assembly optionally includes a cartridge engagement fitting (for example a gripping expander sleeve collar) attached to the coupling. Optionally when the cartridge is engaged to the fitting, the coupling is retained in connection with the access channel to within a second precision. The second precision is optionally higher than the first precision. In some embodiments one or more compliant supports movably retain the fitting oriented to engage the cartridge when the access channel is in the loaded position.

Abstract: In one aspect of the subject invention, a drug delivery device is provided which includes a reservoir for containing a medicament and has a proximal end and a distal end, the medicament including a suspension of solids in a liquid carrier. Further, the drug delivery device includes a needle in fluid communication with the reservoir and having a distal end for injection into a patient, and a proximal end in the reservoir. An accumulation surface is defined at least partially about the needle, distally of the proximal end of the needle. The accumulation surface defines a distally-extending indentation which is sized and shaped to collect, during use, solids that come out of suspension. Advantageously, with the subject invention, the accumulation surface allows for solids to accumulate at a location spaced from the proximal end of the needle, thereby minimizing the possibility of clogging the needle.

Abstract: A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.

Abstract: Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices. Formulations and methods of manufacture are provided for dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations.

Abstract: Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device.

Abstract: A housing for a drug delivery device is disclosed having a first housing component adapted to receive a cartridge at least partially filled with a medicament, and a second housing component adapted to receive a drive mechanism to operably engage with the cartridge for dispensing of a dose of the medicament, wherein the first housing component comprises an insert portion to be inserted in an axial direction into a corresponding receptacle of the second housing component, and wherein the insert portion comprises at least one radially outwardly extending first interlock member to positively engage and to rotationally lock with a correspondingly shaped second interlock member of the receptacle of the second housing component.

Abstract: A coded cartridge holder for use with a drug delivery device is provided. The cartridge holder includes a fastener that becomes operative based in part on a length of a cartridge or a diameter of the cartridge. In one embodiment, the cartridge holder is coupled to the drug delivery device. The cartridge holder comprises a first blocking feature. The drug delivery device includes a cartridge detector comprising a second blocking feature. This feature may be a pin, for engagement with the first blocking feature of the cartridge holder when the cartridge acts on the cartridge detector. The cartridge holder may further include a fastening mechanism configured to fasten the cartridge holder to the drug delivery device only when the second blocking feature engages the first blocking feature.

Abstract: The bioinjection device has a housing including a pistol grip and an elongated barrel. A trigger is pivotally mounted to the housing. An inner shaft having a distal end is slidable between a first position in which the distal end of the inner shaft is disposed in the barrel and a second position in which the distal end of the inner shaft extends past an opening in the end of the barrel. A tip containing a medicament is disposed about the opening of the elongated barrel. The tip includes at least one aperture for dispensing the medicament. One can inject the medicament from the tip into a bone fracture or degenerative bone tissue during surgery by actuating the trigger of the bioinjection device. A configurable tip may be employed to control the amount and direction of dispersion of such medicament.

Abstract: A device for retaining and storing a liquid medium, such as medication, includes a syringe body, a retention and/or storage container, consisting essentially of a glass material, a closure element for the retention and/or storage container consisting essentially of a rubber elastic material, and at least one needle. The retention and/or storage container is a vial having a solid bottom and a pushing device is provided to move the vial in a substantially axial direction in the syringe body, the pushing device acting upon the solid bottom of the vial.

Abstract: The syringe comprises a body containing the liquid and having fitted thereto an endpiece for fastening a needle carrier. The safety device comprises a protective sheath and a syringe support that is received inside the sheath. The sheath and the support are axially movable relative to each other between two positions, namely an uncovered position of the needle, and a retracted position of said needle. The support includes anti-rotation means for constraining it in rotation about its axis and comprising at least one pawl urged resiliently into a position in which the pawl is designed to co-operate with complementary anti-rotation means of the fastener endpiece. The sheath and the support include complementary anti-rotation means for constraining them in rotation relative to each other about their axes and activated at least when the sheath and the support are in their uncovered position of the needle.

Abstract: Fluid delivery and measurement systems and methods are disclosed.

Abstract: A catheter assembly includes a catheter having an elongate tubular body defining a lumen extending from an open proximal end to an open distal end. A cuff deployment device is concentrically supported on the elongate tubular body and is movable along a longitudinal axis of the elongate tubular body. The cuff deployment device includes a deployment mechanism having an actuated position and a non-actuated position. A cuff has a hollow cylindrical body defining an internal catheter engagement surface. The catheter assembly has a first configuration in which the deployment mechanism is in the non-actuated position and the cuff is supported by and movable with the cuff deployment device, and a second configuration in which the deployment mechanism is in the actuated position and the cuff is concentrically mounted at a fixed axial location of the elongate tubular body and is free of contact with the cuff deployment device.

Abstract: A luminous syringe comprises a syringe main body with a hollow chamber formed inside. A mezzanine space is formed between an outer wall of the syringe main body and the hollow chamber, and a light emitting agent and at least one catalyst tube are received within the mezzanine space. A cap is used to close the opening formed on the mezzanine space, and a plunger is provided within the hollow chamber. When in use, a force is applied to press a locating rib on the outside wall of the syringe main body to break the catalyst tube, so that a catalyst came out from the tube is mixed up with the light emitting agent to emit fluorescent light. Then, the syringe is used to draw beverage like coke, cocktail into the hollow chamber and the plunger is pushed by hand to inject the beverage out for drinking.

Abstract: An access port for introduction of a needle cannula tip into an IV tube set includes a rigid tubular housing and a resilient member disposed within an inlet of the housing. The resilient member includes a proximal face exposed to an exterior of the rigid housing and a distal face disposed within the rigid housing. An axial perforation extends through the resilient member, and is normally closed by a resilient character of the resilient member. A depression is defined in the proximal face of the resilient member, and includes sidewalls extending between the proximal face and the axial perforation to guide the needle cannula tip toward the axial perforation as a needle cannula associated with the needle cannula tip is introduced into the access port.

Abstract: Systems, methods, and articles for providing an antimicrobial composition to the proximal elements of a trans-dermal catheter and into the lumen of the transdermal catheter are disclosed. In an embodiment, an antimicrobial composition on surface a cap element transfers antimicrobial to the proximal end of the transdermal catheter. The system comprises an elongate member configured for insertion into a lumen of a catheter, the elongate member containing an antimicrobial.

Abstract: In a prefilled syringe including an elastic seal member to be pierced with a needle for use to eject a protein pharmaceutical preparation therefrom, the elastic seal member ensures smooth and reliable piercing thereof with the needle while reliably preventing an active substance of the protein pharmaceutical preparation from being adsorbed thereon. When a protective film (3) is laminated to a top surface of a seal body (2) of an elastic material, the protective film (3) is stretched to a greater extent by a recess (4) provided in the top surface. Further, the piercing portion to be pierced with the needle is provided in a bottom of the recess (4). Thus, the protective film (3) is formed as locally having a smaller thickness in the piercing portion.

Abstract: A coded cartridge holder system is disclosed for use with a cartridge assembly (20) containing a fluid and a delivery device (10), where the system has keyed connectors (5, 5?, 6, 6?) to prevent accidental attachment of the wrong fluid delivery device (10). The system comprises a coupling (1) attachable to the dose setting portion (12) of the device (10) and keyed to the proximal end of the cartridge holder (14). The cartridge holder (14) may also contain medical coding (27, 28) to correspond to matching coding (27?, 28?) on the distal end of a cartridge assembly (20).

Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.

Abstract: A drug delivery assembly comprises a housing (110), a piston (120) axially displaceable in the housing, and a variable volume reservoir (105) formed by the housing and the piston and containing a fluid first drug. The assembly further comprises an exterior fluid inlet (150) arranged in or configured to be arranged in fluid communication with the reservoir, a fluid outlet (145) arranged in or configured to be arranged in fluid communication with the reservoir, biasing means (130) configured for moving the piston forwards, and releasable retaining means (113) configured for retaining the piston in an initial position, whereby the biasing means is allowed to move the piston forwards to expel fluid drug from the reservoir when the retaining means is released.

Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.

Abstract: A needle and receiver assembly for use with a syringe cartridge filled with medicine includes a cartridge receiver having a hollow interior, an open end sized for receiving at least part of the syringe cartridge, and a closed end opposite the open end. The assembly includes a needle mounted on the receiver having a fluid passage extending between a sharp delivery tip at a distal end of the needle and a sharp access tip at a proximal end of the needle opposite the delivery tip positioned inside the hollow interior of the receiver. The assembly includes a cutter movably mounted in the hollow interior of the receiver for movement relative to the receiver and the needle to cut the diaphragm of the cartridge when received in the hollow interior of the receiver.

Abstract: A needle assembly comprises a body configured for attachment to a drug delivery device. The body defines a cavity. A septum is positioned within the cavity and a stopper positioned within the cavity such that the cavity, septum, and stopper define a reservoir. A double ended needle is positioned in the stopper and septum, the needle comprising a proximal end and a distal end. A release mechanism is positioned near a distal end of the body. A biasing element is positioned to drive the stopper. During a dose dispensing step, the release mechanism drives the proximal end of the needle out of the septum so that the proximal end resides in said reservoir. The biasing element may also drive the stopper proximally.

Abstract: Fluid delivery and measurement systems and methods are disclosed.

Abstract: A safety pen needle assembly is provided herein which includes a hub; a needle fixed to the hub having a distal end, formed for insertion into a patient, and a proximal end; a shield; a biasing means disposed to urge the shield from a first position to a second position; and, at least one adjustable tab or locking finger on the hub, the tab or finger being adjustable from a first state to a second state. With the tab or finger being in a first state, the tab or finger interferingly engages the shield so as to restrict movement thereof. The tab or finger in the first state retains the shield in its first position with the proximal end of the needle being exposed. With the tab or finger being in the second state, the tab or finger does not interferingly engage with the shield. As such, the shield is permitted to be urged proximally to the second position by the biasing means. In the second position, the shield covers the proximal end of the needle.

Abstract: An injector (10) for injecting a medicament into a patient. The injector includes a container (18) defining a first chamber (22), which contains a fluid therein, and a second chamber (23). The injector also includes an injection conduit (126) configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source (62) is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.

Abstract: A fluid dispensing device is provided for dispensing a measured amount of fluid into a living organism. The device has a needle having a first end and a second end. The needle is adapted for interfacing, on the first end, with a septum of a flexible hollow membrane, and at a second end thereof, for subcutaneously inserting into a living organism. The needle is guided by a guide to permit an injection into the living organism at a substantially non-orthogonal angle with respect to a surface of the living organism. The first and second ends of the needle pierce their respective piercing surface while translating together in a common direction. In other embodiments, the dispensing device includes a main housing, a flexible fluid reservoir, an injection assembly and a trigger mechanism. The main housing houses the operative components of the device.

Abstract: Various embodiments of the present invention are directed to equalizing pressure in a reservoir containing fluidic media, possibly due to imperfect installation of the reservoir or an external influence such as an altitude or a temperature change. In various embodiments, fluidic media may be expelled from the reservoir through a needle and contained in an interior volume of a pierceable member before the needle pierces the pierceable member to establish a flow path to a user. In other embodiments, fluidic media may be expelled through a port of the reservoir into a chamber. In further embodiments, fluidic media may be expelled through a channel in a plunger head and out a passage in the reservoir when the channel and passage are aligned. In other embodiments, fluidic media may be expelled through a valve, and the valve may be pierceable by a needle to establish a flow path to the user.

Abstract: A locking assembly for a medication dispensing device including a housing, a drive member, a medication cartridge having a barrel holding medication between a movable plunger and a septum, and a dose delivery mechanism for controlling the advancement of the drive member. The locking assembly, in one form, includes a lock member, biased to move from a first position to a second position, with a first actuating element. The locking assembly also includes a second actuating element disposed on the drive member and cooperatively configured with the first actuating element. If the drive member of the device moves rearward from the shipped position due to a freezing of the medication, the second actuating element engages the first actuating element such that the lock member moves from the first position to the second position to lock the medication dispensing device from further dose dispensing.

Abstract: Various embodiments of the present invention are directed to equalizing pressure in a reservoir containing fluidic media, possibly due to imperfect installation of the reservoir or an external influence such as an altitude or a temperature change. In various embodiments, fluidic media may be expelled from the reservoir through a needle and contained in an interior volume of a pierceable member before the needle pierces the pierceable member to establish a flow path to a user. In other embodiments, fluidic media may be expelled through a port of the reservoir into a chamber. In further embodiments, fluidic media may be expelled through a channel in a plunger head and out a passage in the reservoir when the channel and passage are aligned. In other embodiments, fluidic media may be expelled through a valve, and the valve may be pierceable by a needle to establish a flow path to the user.

Abstract: An injection syringe, having a syringe cylinder, a plunger rod inserted therein and connected to a stopper by way of a coupling part, and a module that is provided in the proximal end of the syringe cylinder and having a cannula, mounted in a cannula holder received in a guided sleeve, and a sealing insert for the fluid-tight closure of the proximal end of the syringe cylinder and a protection cap for protecting the cannula, wherein the protective cap on the inner circumference has ribs extending in an axial direction, which engage in corresponding grooves of the driving part for a rotary drive thereof, and wherein in the sealing insert a hollow space is formed, which is closed on the proximal side and on the distal side transitions into an opening, by way of which a tip of the coupling part can be coupled to the hollow space.

Abstract: A vascular access device for communicating with the vascular system of a patient may include a status indicator. The status indicator may detect and signal that a period of time has elapsed in relation to the use of the vascular access device.

Abstract: The present invention inter-alia relates to an apparatus comprising a needle guide configured to at last partially receive a needle of a needle assembly in a longitudinal opening and to center the needle of the needle assembly in the longitudinal opening, wherein the needle guide is longitudinally compressible.

Abstract: An injection device (100), including a base (104), a sliding body (116) slidably connected to the base (104), a double-ended needle (120) fixed to the sliding body (116), a biasing member (124) for proximally biasing the sliding body (116) with respect to the base (104), and for retracting the needle (120) into the device (100) subsequent to activation of the device (100), a medicament cartridge (128) for holding a medicament, slidably connected to the sliding body (116), and a stopper (132) slidably disposed within the medicament cartridge (128). The base (104) has a proximal end (108) and a surface (164) disposed at a distal end (112) thereof for contacting a patient's skin. The base (104) also has a first locking mechanism. The sliding body (116) has a locking feature and a second locking mechanism. The second locking mechanism locks the medicament cartridge (128) relative to the sliding body (116) upon completion of displacement of the medicament cartridge (128) relative to the sliding body,(116).

Abstract: The invention relates to a protection device (10) for a needle of an assembly or of an injection device having a hub portion provided with a needle, the said protection device (10) comprising: an outer casing (20) formed of a first material; and an inner casing (30) formed of a second material different from the said first material and defining a cavity (32) for receiving in a sealing way at least the hub portion, said cavity (32) having an inner wall (34); attachment means (40) defined in the said cavity (32) to removably engage and secure said protection device (10) at least along a sealing line to the injection device; the protection device being characterized in that it further comprises aspiration limiting means (40, 50) for limiting the deformation of said cavity (32) when said protection device (10) is separated from the assembly or the injection device.

Abstract: In a prefilled syringe including an elastic seal member to be pierced with a needle for use to eject a protein pharmaceutical preparation therefrom, the elastic seal member ensures smooth and reliable piercing thereof with the needle while reliably preventing an active substance of the protein pharmaceutical preparation from being adsorbed thereon. When a protective film (3) is laminated to a top surface of a seal body (2) of an elastic material, the protective film (3) is stretched to a greater extent by a recess (4) provided in the top surface. Further, the piercing portion to be pierced with the needle is provided in a bottom of the recess (4). Thus, the protective film (3) is formed as locally having a smaller thickness in the piercing portion.

Abstract: A device for storing and administering drug includes a housing, a sealing element (3) and a separate low friction plunger (4) which is substantially-permeable to gas over time. The sealing element (3) is typically broken to allow delivery of the drug. The housing (2) may be filled with the drug through an opening other than the opening through which the pusher (13) enters the housing to move the plunger so as to expel the drug during administration to a patient.

Abstract: The present invention relates to drug delivery device and a and method of manufacturing a drug delivery device with a housing having a proximal end and a distal end, a cartridge adapted to accommodate a drug, a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member being secured to the housing, and a spring washer being arranged within the housing so as to exerting a force on the cartridge and securing the cartridge against movement with respect to the cartridge retaining member and against movement with respect to the housing.