Abstract: An apparatus includes a first member and a second member. The first member is configured to receive a portion of a syringe barrel and includes a first stop surface. The second member includes a second stop surface. Each stop surface is configured to engage the portion of a plunger to thereby arrest longitudinal movement of the plunger relative to the syringe barrel. The second member is operable to move relative to the first member from a first position to a second position. The second member remains coupled with the first member while in both the first position and the second position. The second stop surface engages the portion of the plunger when the second member is in the first position. The second stop surface does not prevent the portion of the plunger from reaching the first stop surface when the second member is in the second position.

Abstract: Disclosed is a syringe for a micro-dosing syringe pump. The syringe includes a reservoir having an outlet port; a plunger having a track, with the plunger received inside a portion of the reservoir; a plunger driver comprising a gear connected to one end of a shaft and a pin located adjacent an opposite end of the shaft, with the plunger driver received inside the plunger and with the pin located inside and engaging the track. In use, rotation of the gear in a first direction advances the plunger into the reservoir a first distance as the pin travels in the track and rotation of the gear in a second direction opposite the first direction advances the plunger a further distance into the reservoir as the pin travels in the track. The design prevents excess dosing in a runaway motor failure.

Abstract: An incremental syringe useful for multiple injections of medications like botulinum toxin is provided. The syringe includes detents on the syringe plunger which provide a tactile feeling, a discrete audible sound or “click,” or preferably both, for every unit of medication aspirated or injected to or from an individual syringe. Hence, there is no need to look at the syringe, or bring it to the eye level, during use thereof. In some embodiments, a second set of detents is included, and in some embodiments a third set of detents is included. Syringe plungers useful for combining with a syringe body to produce such an incremental syringe are also described.

Abstract: The present disclosure relates to a medicament injection device (1) comprising a housing (3) arranged to receive a medicament container (11a), a needle cover (9) movable relative to the housing (3), from a retracted position, in which it engages the housing (3) and enables medicament delivery, to an extended position, a plunger rod (7), and a plunger driver (5) movable relative to the housing (3) from all initial position to a final position, and arranged to actuate the plunger rod (7), wherein the plunger rod (7) has a first guide arrangement and the housing (3) has a second guide arrangement, the first guide arrangement (7d) and the second guide arrangement being arranged to cooperate to guide movement of the plunger rod (7) relative to the housing (3), wherein the first guide arrangement and the second guide arrangement in a first stage provide a linear motion path for the plunger rod (7), enabling the plunger rod (7) to initially move in the axial direction and in a second stage provide a rotation motion

Abstract: A medical device (100) for the instillation of medical products in droplet form is described, said device comprising a hollow cylindrical body (10) and a rod (20) slidably mobile inside the hollow cylindrical body (10) and provided with a head (21) on which a rubber washer (40) is fixed, which washer, during the sliding of the rod (20), is in contact with an inner surface of the hollow cylindrical body (10). The rod (20) is formed as two portions (22, 24) of different diameter and the device (100) further comprises a sealing bush (30) between the hollow cylindrical body (10) and the rod (20), wherein there is provided a stop (32) which prevents the passage of the portion (22) with a larger circular section of the rod (20).

Abstract: A syringe holder includes a syringe barrel holder having a depression which is configured to receive and engage finger tabs of a syringe and has a bottom depression surface engageable by the finger tabs. A barrel opening receives a barrel of the syringe, and includes a central longitudinal axis, a shaft channel and a set screw channel having a screw axis passing through the shaft channel. A dosing shaft extends from a first end to a second end and includes a plurality of notches between the ends. The dosing shaft is located and slideable within the shaft channel. A plunger cap includes a plunger receptacle and attaches to a first end of the dosing shaft. A socket set screw is located and engaged within the set screw channel and has a resilient end engageable with the notches of the dosing shaft.

Abstract: Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the catheter are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element.

Abstract: The disclosure relates to a syringe, comprising a barrel and a plunger, wherein at least a part of said plunger is longitudinally slidably received in the barrel, wherein the plunger comprises a portion that is provided with at least one series of interspaced plunger formations, wherein the barrel is provided with a corresponding barrel formation for consecutively engaging successive ones of the plunger formations, wherein the syringe is arranged such as to be brought from a first state in which the barrel formation successively engages the plunger formations during slidable displacement of the plunger within the barrel, into a second state in which the barrel formation is held in a position spaced away from the plunger portion that comprises the plunger formations.

Abstract: A medicament delivery device extends along a longitudinal axis and includes: a generally tubular elongated housing having a proximal and a distal end, where the generally tubular elongated housing is arranged to accommodate a medicament container; a drive unit comprising a drive element and plunger rod operably arranged to act on the medicament container; a tubular element rotatable rotatably arranged in relation to the housing and operably arranged to the plunger rod, where the plunger rod includes at least one holding member and where the tubular element includes at least one arm extending generally transversal to the longitudinal axis of the device, wherein the at least one arm is arranged to engage the at least one holding member on plunger rod to releasable hold the drive unit in an energy accumulated state.

Abstract: A syringe including a barrel, a plunger moveably arranged within the barrel and a plunger rod for driving the plunger, and an engagement member arranged at the barrel to engage with a grooved surface on the plunger rod. This will create feedback given to a user as the plunger rod is moved relative to the barrel for driving the plunger within the barrel. The barrel and the engagement member are arranged relative to each other such that the engagement member, due to the engagement with the grooved surface of the plunger rod, will move solely in a direction generally perpendicular to a longitudinal direction of the plunger rod as the plunger rod is moved relative to the barrel.

Abstract: An adjustable dosage limiting device is includes an elongated connecting member that has a plunger receiving head at a first end for capturing a plunger flange of a plunger of a syringe. A slidable member having a barrel loop is movable along the elongated connecting member. The slidable member slides up/down the elongated connecting member until, at a preset dosage, a locking mechanism is engaged to lock the slidable member, and hence the barrel loop, in place on the elongated member. Once locked in place, the adjustable dosage limiting device limits a dosage provided by the syringe based upon a distance between the plunger receiving head and the barrel loop as set by the locking mechanism.

Abstract: A dosage limiting device is includes an elongated connecting member that has a plunger receiving head at a first end for capturing a plunger flange of a plunger of a syringe. The plunger receiving head has a back flange connected to the elongated connecting member and a forward slotted flange connected to the elongated connecting member, the forward slotted flange is separated from the back flange by a space sufficient to accept the plunger flange and a flat section of the plunger fitting in a slot of the forward slotted flange. A barrel loop is at a distal second end of the elongated connecting member so that the dosage limiting device limits a dosage provided by the syringe based upon a distance between the plunger receiving head and the barrel loop as the barrel loop abuts a barrel flange of the syringe, thereby limiting extraction of the plunger.

Abstract: A fluid dispensing device having a barrel having a lumen for containing a fluid therein and a flexible structure extending from the barrel. A plunger is axially slidable within the lumen to dispense fluid from the barrel, the plunger having a first set of grooves spaced apart a first distance and a second set of grooves spaced apart a second distance. The flexible structure includes a flexible arm extending transversely with respect to the barrel and configured to engage the grooves.

Abstract: A plunger for a syringe may include a plunger head for fluid dense limiting a fluid chamber of the syringe, and a piston rod fixed to the plunger head. The piston rod may be formed by longitudinally extending axial webs that have an outwardly radial extension from the longitudinal axis and lead into a common crossing section. A free activation edge, which radially protrudes the radial extension may be provided on the piston rod and engageable with a vibration activator of a hollow body of the syringe to emit an acoustic signal. A swinging arm body may be arranged between two axial webs and couple the activation edge with the crossing section such that in case of a vibration activation in an axial direction the swinging arm body has a radial swinging arm length between the activation edge and the crossing section of at least 40% of the radial extension.

Abstract: An incremental syringe useful for multiple injections of medications like botulinum toxin is provided. The syringe includes detents on the syringe plunger which provide a tactile feeling, a discrete audible sound or “click,” or preferably both, for every unit of medication aspirated or injected to or from an individual syringe. Hence, there is no need to look at the syringe, or bring it to the eye level, during use thereof. In some embodiments, a second set of detents is included, and in some embodiments a third set of detents is included. Syringe plungers useful for combining with a syringe body to produce such an incremental syringe are also described.

Abstract: An apparatus includes a housing, a medicament container and a movable member. The medicament container is configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member is configured to exert the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member is configured to exert a retraction force on the flange to move the medicament container from the second position towards the first position.

Abstract: Described herein are syringe accessories that can be attached to standard syringes. These accessories utilize one or more mechanisms that can provide at least one additional sensory feedback to the user when performing an aliquot or dosed injection. In other embodiments, the accessories can prevent overdosing.

Abstract: A medical injector has a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally toward a distal end of the body but not proximally toward a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger, thereby allowing the engagement portion to bypass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector.

Abstract: A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the scaling member and the housing.

Abstract: A balloon pressure pump comprising a cavity (1) having a distal end and a proximal end; a push rod (2) having a distal end and a proximal end, and provided with an external thread and inserted into the cavity; a handle (3) fixedly connected with the proximal end of the push rod (2); a locking member (4) having a distal end and a proximal end and arranged on the proximal end of the push rod (2) and used to lock same; the distal end of the locking member (4) is fixedly connected with the proximal end of the cavity (1). The handle (3) is internally provided with a sleeve (5) to accommodate the push rod (2); said sleeve (5) is fixedly connected with the proximal end of the locking member (4). The proximal end of the push rod (2) includes a spring (11) which is enclosed within the sleeve. The simple structure of the pump simplifies operations such as pressure application, pressure relief, negative pressure evacuation and the like, and is greatly convenient for a user.

Abstract: A storage tray for one or more syringes includes a recess for each of the syringes to be held in the tray. Each recess has first and second opposed sidewalls that define a space therebetween for receiving the barrel of the syringe. Each of the first and second sidewalls has one or more deformable projections thereon that protrude into the space between the sidewalls for positively retaining the barrel of the syringe between the first and second sidewalls. Additionally, a slot is provided for receiving the thumb rest of the plunger. The slot includes a third sidewall oriented generally transverse to the first and second sidewalls, with the third sidewall including a further projection for engaging a surface of the thumb rest. Preferably, a plurality of such transverse slots is provided to accommodate different positions of the plunger relative to the syringe barrel.

Abstract: A syringe for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe is designed in such a manner that it is ensured that substantially all of the mixed drug is ejected, and in such a manner that an active pharmaceutical ingredient can be lyophilized directly into the syringe. The syringe comprises a syringe body, a first plunger arranged movably inside the syringe body and a second plunger arranged movably inside the first plunger. In one aspect the second plunger comprises a first plunger part and a second plunger part, and the first and second plunger parts are adapted to cooperate to collapse the cavity of the first plunger. In a second aspect the cavity of the first plunger has a first diameter at a distal end and a second diameter at a proximal end, the first diameter being smaller than the second diameter.

Abstract: Device for medicament delivery with syringe-like usability having a restraining mechanism A device for medicament delivery with syringe-like usability comprising at least one grip, at least one medicament container holder, and at least one plunger rod being substantially rotationally fixed relatively to the grip. The medicament container holder (13) is movable towards the grip in a longitudinal direction of the device, and rotation of at least one rotatable part (40), which is rotatable relatively to the grip and substantially inhibits movement of the plunger rod (20) in a longitudinal direction for dose delivery when in at least one locking position until being rotated, is restrained by at least one restraining member (42) abutting or being connected to the rotatable part (40) and the grip (30) until the medicament container holder is moved towards the grip for interacting with the at least one restraining member.

Abstract: A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: An administration device can discharge a prescribed, equal amount of medicine a number of times by spraying. A spraying device includes a barrel; a gasket provided slidably movable in liquid-tight manner in the barrel; a rod coupled to a base end of the gasket; and a regulating member provided on the barrel, having a projection that can slidably fit with the guide groove. The guide groove includes at least first and second continuous administering grooves. The second administering groove is configured to include a transitional portion extending in the circumferential direction with a groove wall on the base end side aligned with the base end of the first administering portion, and a second administering portion extending from the transitional portion to a base end along the longitudinal direction. An energizing protrusion engageable with the projection is provided at a boundary between the transitional portion and the second administering portion.

Abstract: A lockable syringe having an actuating mechanism for rapidly and selectively placing a movable thread bearing plunger member and stationary internally threaded cylinder into or out of threaded engagement, particularly for using the syringe to pressurize therapeutic medical balloon catheters, or the like. The mechanism includes a plunger having both a piston at its end to engage a barrel portion of a unitary syringe body, selectively deployable and retractable threaded segment, and an internally threaded cylindrical structure disposed within a unitary syringe body having a barrel. The plunger is engageable with the threaded cylinder by means of a threaded segment, and an operator actuated desmodromic arrangement to controllably reciprocate the threaded segment in a positive manner in order to allow either rapid manual or thread controlled plunger and piston movement within the syringe's barrel for purposes of displacing or pressurizing working fluid contained therein.

Abstract: Syringe devices and accessories for providing feedback to a user are disclosed.

Abstract: Syringe devices and accessories for providing feedback to a user are disclosed.

Abstract: Ocular implant insertion apparatus configured for screw-type and push-type operation and associated methods. Such insertion apparatus includes a main body defining a longitudinal axis and a plunger, movable relative to the main body, including a rod portion and an operational portion rotatably mounted on the rod portion. One of the main body and the plunger operational portion includes a helical slot and at least one longitudinally extending clearance groove that intersects the helical slot and the other of the main body and the operational portion includes at least one protrusion that is sized and shaped to fit within the helical slot and within the at least one longitudinally extending clearance groove.

Abstract: Methods of transdermally delivering a therapeutic amount of a triazole-triazolone compound are provided, e.g. for the prevention or treatment of basal cell carcinoma (BCC) in a subject. A therapeutic level of a triazole-triazolone compound such as itraconazole is delivered transdermally to a subject. Also provided are topical triazole-triazolone compositions that find use in practicing the subject methods.

Abstract: A coded cartridge holder system is disclosed for use with a cartridge assembly (20) containing a fluid and a delivery device (10), where the system has keyed connectors (5, 5?, 6, 6?) to prevent accidental attachment of the wrong fluid delivery device (10). The system comprises a coupling (1) attachable to the dose setting portion (12) of the device (10) and keyed to the proximal end of the cartridge holder (14). The cartridge holder (14) may also contain medical coding (27, 28) to correspond to matching coding (27?, 28?) on the distal end of a cartridge assembly (20).

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: An injection device defines a longitudinal center axis, a proximal direction and a distal direction. The injection device includes a housing having a receptacle for an injection fluid vessel and an operator-manipulated element configured to be rotatable to set an amount of injection fluid to be dispensed. The operator-manipulated element is further configured to move relative to the housing in the direction of the center axis in the distal direction when rotated. The operator-manipulated element further is displaceable in the proximal direction to dispense injection fluid. A feed part is connected to the operator-manipulated element in a rotatably fixed manner and is displaced in the direction of the center axis in the distal direction during the setting of the amount of injection fluid to be dispensed. The feed part is connected to the housing in a rotatably fixed manner and is displaced in the direction of the center axis in the distal direction when the injection fluid is dispensed.

Abstract: A lock for a dosing mechanism of an injection device, the lock including at least one holding element that interacts with the dosing mechanism, or with a dosing element of the dosing mechanism, whereby an adjustment movement of the dosing mechanism or the dosing element is prevented in a starting position of the lock and is possible only after a movement or displacement of the lock or the holding element. An injection device used in conjunction with a two-chamber ampoule is encompassed, as is a method for preparing the injection device for dispensing a substance wherein the ampoule is introduced into the injection device and a lock is released when the ampoule has been introduced far enough to appropriately mix the substances in the two chambers, whereupon the mixed substances can be dispensed from the ampoule.

Abstract: A device for delivering medicament includes a guide nut with guide ledges which cooperate with longitudinal grooves of a plunger rod for providing a rotational lock but allowing longitudinal movement of the plunger rod in relation to the guide nut that is rotationally locked to a distal housing part by engagement devices when the distal housing part and a proximal housing part are connected to each other. The device further includes a pressure release mechanism that includes slanting wedge-like surfaces arranged on the drive nut and slanting wedge-like surfaces arranged on a fixed inner annular surface of the distal housing part, which slanting wedge-like surfaces abut each other such that they move out of contact near the end of delivery of a predetermined quantity of medicament when the drive nut is rotated.

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract: A medical delivery system (200) having a container (202) and a dosing assembly (204), where the container is fastenable to the dosing assembly by a movement comprising a translatory movement followed by a rotational movement. One of the container and the dosing assembly comprises one or more blocking elements (207) movable between a blocking position and a non-blocking position responsive to the rotational movement. Each blocking element is able to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system.

Abstract: A positive displacement flush syringe includes a barrel having a chamber for retaining fluid and an elongate tip extending distally therefrom having a passageway therethrough in fluid communication with the chamber. A plunger having a stopper which is slidably positioned in said chamber for driving fluid out of the chamber by movement of the stopper relative to the barrel is provided. Further, structure is provided to move fluid distally in the passageway after fluid has been delivered from the chamber and the stopper is in contact with the distal wall of the chamber.

Abstract: A pen type device for ultrasound guided fine needle aspiration cytology and biopsy comprises a hollow body having a needle hole, a sliding part slidably mounted inside the body, elastic members mounted inside the body, a syringe having a cylinder mounted, a rotating part disposed inside the sliding part and the body, a head screw-coupled to the rear end of the sliding part and drawn out from the body, and a negative pressure generating part mounted on the body to generate negative pressure to the syringe by pulling a piston of the syringe when a button located on the outer face of the body is pushed.

Abstract: A needle protective housing used to cover a contaminated needle after use is configured to have at least one cam positioned below the lip of the sheath attached to the base of the needle device for covering the needle prior to use. When the sheath is attached to the base of the needle device, the needle protective housing is positioned in proximity to the sheath. To remove the sheath, a user would pivotally move the needle protective housing in a direction away from the sheath so that the cam coacts against the lip of the sheath in an upward direction as the needle protective housing is pivoted downwards relative to the needle device. The cam may be an integral extension of the needle protective housing, or it may be a clip retrofittable to the needle protective housing.

Abstract: Described generally herein are tissue therapy devices, which may comprise a sealant layer and a suction apparatus. The sealant layer functions so as to create a sealed enclosure between it and the surface of a patient by forming, preferably, an airtight seal around an area of tissue that requires negative pressure therapy. The tissue therapy device may comprise a suction apparatus. The suction apparatus is typically in fluid communication with the sealant layer and functions so as to reduce the amount of pressure present underneath the sealant layer. The reduced pressure is self-created by the suction apparatus. Together the sealant layer and the suction apparatus preferably create a closed reduced pressure therapy system. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of the air molecules under the sealant layer.

Abstract: A device for administering an injectable substance, the device including a housing, a translation member moveable in a translation direction, a rotation member rotatably moveable about a rotation axis and coupled to the translation member to support the translation member counter to the translation direction, a rotary bearing including a bearing body bearing the rotation member rotatably about the rotation axis, the rotary bearing having support surfaces for supporting the rotation member axially on the bearing body, and a device for reducing play whereby at least two support surfaces are brought into contact with a pressing force, thereby reducing an axial play of the rotary bearing.

Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.

Abstract: The invention concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a housing having an interior thread formed as an outwardly pointing thread carried on an upstanding tower centrally located in the pen shaped device. This outwardly pointing thread forms a first thread connection with the interior thread of the rotatable scale drum. The injection device further comprises a driver for moving the piston rod forward when moved axially. The driver operates the piston rod through a second thread connection having a pitch different than the first thread connection.

Abstract: A delay mechanism for staging the operation of an automatic injection apparatus (20) to ensure medication contents are properly delivered prior to the needled syringe (32) of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (50), a follower (110), a locking member, a damping compound, and a driver and a driver biasing element (44). The shuttle is for a needled syringe of the apparatus and includes a first latching element. The follower includes a second latching element and a cammable surface, which second latching element is for cooperating with the first latching element to limit motion of the shuttle relative to the follower in a second direction opposite the first direction.

Abstract: Syringe assemblies for use in flush applications are provided. Syringe assemblies according to one aspect of the present invention include a plunger rod and a syringe barrel that incorporate one or more pulsing elements on the plunger rod or barrel that are rotatable to create pulsatile movement or continuous and unimpeded movement a plunger rod within a syringe barrel. One or more embodiments pertain to syringe assemblies permit both pulsatile movement of the plunger rod within the barrel and continuous and unimpeded movement of the plunger rod in the distal direction along substantially the entire length of the syringe barrel upon application of force to the plunger rod in only the distal direction. Methods of flushing a catheter are also provided.

Abstract: The invention relates to a discharge device for discharging a fluid product, for example, in the form of a syringe. The discharge device comprises a housing (1), which bounds a reservoir (16), and a piston (23), which is slidably arranged in the housing (1) in a longitudinal direction in order to discharge the fluid product distally from the reservoir (16) through an outlet opening (13). A window opening (15) is formed in a circumferential side wall (11) of the housing (1). An insert element (3) is inserted into said window opening (15) perpendicularly to the longitudinal direction. The insert element (3) protrudes into the reservoir (16). In this way, a motion of the piston (23) can be limited in the proximal direction in order to prevent the piston (23) from falling out, and the metering of the fluid product can be made easier in that the insert element (3) establishes a detachable locking connection with an advancing element (27) for the piston (23).

Abstract: A plunger (4) having engaging means and a lever (5) are arranged in a body (1). The lever has a first pivot that is stationary with respect to the body in the direction of an axis, a second pivot, and a third pivot formed by an engaging element of the lever. The pivots are arranged in such a manner that a rotation of the lever with respect to the first pivot moves the second pivot and the third pivot in the same direction with respect to the axis. The engaging element and the engaging means are shaped such that the lever is disengaged from the plunger when the second pivot is moved relatively to the plunger in the proximal direction (30), and the plunger is engaged with the lever when the second pivot is moved in the distal direction (20).

Abstract: A plurality of dosage-control members are detachably connected to the plunger rod of a multi-dose syringe along two opposing sides of the rod. Each dosage-control member has a cut in which the external diameter of the top rim of the syringe fits to prevent forward and reverse movement of the rod. Removal of one dosage-control member from one of the two opposing sides of the rod permits forward movement of the rod and plunger until the top rim snaps into the cut of another dosage-control member. Flexible salient arms extend obliquely from the rod in one-to-one correspondence with the dosage-control members to prevent reverse movement of the rod.