Abstract: A wound care device for delivering topical oxygen therapy, negative pressure wound therapy, and a low intensity vacuum therapy for treatment of a wound. The wound care device may include an oxygen supply mea, an oxygen consuming mea, a vacuum pump and motor, a pressure sensor, and a power supply and electronic controls. A dressing may be connected to the wound care device for administering topical continuous oxygen therapy and simultaneous negative pressure wound therapy to a wound. A canister or exudate trap may be positioned between the dressing and the vacuum supply port of the vacuum pump to collect and store exudates from the wound. The canister may be combined with the dressing.

Abstract: The invention relates to a carrier for oromucosal, especially sublingual administration of physiologically active substances, especially of medicinal drugs, which consists of at least one elastic layer (1) of polymer nanofibres workable according to the shape of the selected wall of mouth cavity to which it should be applied and in this elastic layer (1) of polymer nanofibres a drug and/or other physiologically active substance are deposited in a releasable manner.

Abstract: The disclosure concerns various devices implemented to provide a therapeutic gas rich environment to promote healing, reduce fibrosis and scar formations while maintaining anti-inflammatory, anti-thrombotic, antimicrobial, and vasodilating properties. The device generally includes a gas-donor composition that is embedded within a fibrous holding layer. Coupled to one side of the fibrous holding layer is a water-permeable layer and coupled to an opposite side of the fibrous holding layer is a gas-permeable layer. The water-permeable layer is configured to receive and communicate water to the gas-donor composition, wherein upon contact with the water, the gas-donor composition is configured to deliver a therapeutic gas through the gas-permeable layer to a treatment site of a subject.

Abstract: The invention relates to a wound care arrangement comprising a covering unit that can be fixed on the skin surrounding a wound and that serves for producing a closed wound space comprising the wound, and a suction connection via which a vacuum can be produced in the wound space, wherein the covering unit is penneable to water vapor at least in sections.

Abstract: The present disclosure relates to a connector device for a negative pressure wound therapy system having a connector housing, a fluid outlet connected to the connector housing, an air feeding port and an air filter and coupling means. The fluid outlet is adapted to be connected to a negative pressure source. The connector device is adapted to be engaged with a wound side connector of a wound side assembly by means of the coupling means. The wound side assembly includes a fluid removing conduit and an air supplying conduit, wherein a portion of each one of the fluid removing conduit and the air supplying conduit is connected to the wound side connector. The connector device when engaged with the wound side connector, the fluid removing conduit is fluidly connected to the fluid outlet and the air supplying conduit is fluidly connected to the air feeding port such that air ambient of the connector device can be fed to the air supplying conduit via the air feeding port and the air filter.

Abstract: A negative pressure wound dressing for use with breast incisions. The wound dressing includes a drape layer, a manifold layer, a base layer, and a reduced pressure interface. The drape layer has a first surface and a second, wound-facing, surface. The drape layer is substantially impermeable to liquid and substantially permeable to vapor. The manifold layer has a first surface and a second, wound-facing surface. The manifold layer has a perimeter defined by a first convex curved side surface defining a first lobe, a second convex curved side surface defining a second lobe, and a connecting portion between the first lobe and the second lobe. The base layer is configured to: (i) couple the drape layer to the manifold layer, and (ii) the dressing to a patient's tissue. The reduced pressure interface is integrated with the drape layer.

Abstract: Embodiments of negative pressure wound therapy systems, apparatuses, and methods for operating the systems and apparatuses are disclosed. In some embodiments, a medical device is configured to detect an identity of a patient-contacting disposable connected to the medical device. The medical device automatically modifies one or more operational parameters of the medical device based on the identity of the patient-contacting disposable connected to the medical device. The medical device can include a user interface and modify automatically available selections in the user interface based on the identity of the patient-contacting disposable connected to the medical device.

Abstract: A composite material is described, which is of particular use in wound treatment, and to a method for producing said composite material is also described. The composite material has a first foam layer having a first hydrophilic polyurethane foam material, and, in immediate contact therewith, a second foam layer having a second hydrophilic polyurethane foam material, which second hydrophilic foam material is different from the first hydrophilic foam material.

Abstract: The present disclosure relates to a medicament delivery device comprising a medicament receiving element, at least one fluid chamber having a fluid outlet configured to direct fluid vapour towards the medicament receiving element, a heating element for heating the fluid in the at least one fluid chamber. The device is configured such that, in use, the heating element heats the fluid in the at least one fluid chamber to at least partially evaporate the fluid so that the vapor pressure in the at least one fluid chamber increases until the fluid is expelled out of the at least one fluid chamber through the fluid outlet towards the medicament receiving element and entrains the medicament towards the patient's skin.

Abstract: A perianal support device includes a central support element with an apex having a continuous contact surface along the apex to interface with a patient's perianal tissue. Compression elements extend laterally away from each apex side of the central support element. Each compression element may have a narrower proximal end to the central support element and a wider distal end, and be flexible to bend to the gluteal cleft anatomy. The surface of each compression element that faces the patient in use may be covered, at least partially, with a loop material on the wider distal end. Each compression element may also have the opposite surface covered, at least partially, with foam. The central support element and compression elements may be integrally formed. A gripping tab is also provided at a distal end of each compression element, providing an easy location for medical staff to grasp for placement and removal.

Abstract: The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and/or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and/or joint surgery.

Abstract: The present invention relates generally to therapeutic articles comprised of carbonaceous blend textile materials comprising yarns having about 25 to 100 weight % carbonaceous fiber and about 0 to 75 weight % fiber made of polyester, nylon, rayon, lyocell, cellulose, wool, silk, linen, bamboo, m-aramid, p-aramid, modacrylic, novoloid, melamine, regenerated cellulose, polyvinyl chloride, antistatic fiber, poly(p-phenylene benzobisoxazole) (PBO), polybenzimidazole (PBI), polysulphonamide (PSA), and combinations thereof, or other fibers not listed that are capable of being made into yarn and textile fabrics that are knit, woven, or nonwoven, and wherein the fabric has a weight from about 3 oz/yd2 to about 20 oz/yd2.

Abstract: A wound treatment apparatus is provided for treating tissue damage, which comprises a fluid impermeable wound cover sealed over a site for purposes of applying a reduced pressure to the site. The apparatus also can include a cover with protrusions on its surface for purposes of monitoring pressure at the site. One or more sensors can be positioned under the cover to provide feedback to a suction pump controller. The apparatus can have a miniature and portable vacuum source connected to the wound cover.

Abstract: Systems and methods of providing post-operative ostomy patient care can include software and/or hardware that facilitates patient care personnel, such as a patient coach, providing remote patient care or coaching over a network to an ostomy patient. The care may be provided by specially trained former patients, nurses, or other care providers. The system can integrate sensor data from an ostomy device and inputs from the former patients, healthcare professionals, and/or device manufacturer in provide the post-operative care.

Abstract: In one embodiment, a composition is provided, comprising: 0.0005 wt % to 0.04 wt % of silver nitrate, based on a total weight of the composition; 0.01 wt % to 1.0 wt % of hyaluronic acid, based on the total weight of the composition; and 0.05 wt % to 2.5 wt % of allantoin, based on the total weight of the composition. In one embodiment, a method of treating a skin wound is provided, comprising: topically applying a sufficient amount of a composition to the skin wound of a patient to cover the skin wound, the composition comprising: 0.0005 wt % to 0.05 wt % of silver composition, based on a total weight of the composition; 0.01 wt % to 0.1 wt % of hyaluronic acid, based on the total weight of the composition; and 0.05 wt % to 2.5 wt % of allantoin, based on the total weight of the composition.

Abstract: A formable cast (100), brace (180) or splint is provided herein which comprises a padding (101), an outer shell (103) spaced apart from the padding, and a ridge (109) disposed along the perimeter of the shell. The ridge, shell and padding define an interior space (115), with a curable polymeric material disposed in the interior space. The curable polymeric material undergoes a phase transition, upon curing, from a liquid or gel phase to a substantially rigid solid phase. The cast (100), brace (180) or splint may be readily customized to the patient by fitting the cast to the patient's body, positioning the cast in the desired orientation, and curing the curable polymeric material through exposure to actinic radiation or by other suitable means.

Abstract: According to an aspect of some embodiments of the present invention there is provided a method of dynamically adapting a facial treatment based on a current facial skin profile, comprising: using at least one sensor for measuring at least one current value of at least one variable skin characteristic of facial skin of a patient; acquiring at least one personal skin characteristic of facial skin of the patient; calculating a current facial skin status of the patient according to the at least one personal skin characteristic and the at least one current value; determining instructions to operate a treatment applicator according to the current facial skin status; and instructing the treatment applicator according to the instructions.

Abstract: A collecting bag for human body wastes having a barrier film covered by a comfort layer attached to the barrier film in an attachment zone wherein the comfort layer is a textile material that is attached to said barrier film in one or more zones of attachment and wherein threads of the textile material have a higher melting point than that of the barrier film material in the attachment zone.

Abstract: A device manages thermal energy applied to a composite patch on a structure having a heat sink. The device includes an enclosure configured to be placed on the structure overlying the composite patch, and a phase change material within the enclosure for absorbing the thermal energy.

Abstract: A wound therapy apparatus is disclosed that includes a wound interface securable to a skin surface around a wound bed to form an enclosed space over the wound bed that is fluid-tight. The wound therapy apparatus may include a dressing engaged with the wound interface to contact the wound bed. Gas within the enclosed space may have an O2 concentration greater than the O2 concentration in atmospheric air. The dressing may include a hydrophobic material, hydrophobic material, or a distal layer comprised of silicone having fenestrations therein, in various aspects. The pressure p0 within the enclosed space may vary over a pressure range pmin?p0?pmax. Related methods of use are also disclosed.

Abstract: A staple cartridge comprising a cartridge body, a plurality of staples, and an absorbable adjunct releasably secured to the cartridge body is disclosed. A plurality of staple cavities are defined in the cartridge body and the plurality of staples are removably positioned in the staple cavities. The absorbable adjunct comprises a first zone comprising a tissue-supporting surface, a second zone comprising a cartridge body contacting surface, and an intermediate zone position between the first zone and the second zone. The first zone comprises a first compressibility and the second zone comprises a second compressibility that is less than the first compressibility. The intermediate zone comprises a third compressibility greater than the first compressibility.

Abstract: The present disclosure describes articles, such as medical articles, containing a substrate having disposed thereon a hydrophilic gel material (e.g., a shaped hydrophilic gel material or a coating of a hydrophilic gel material) and methods for making such articles. Methods are provided for making hydrophilic gel materials from a precursor composition that contains a polar solvent and a polymerizable material that is miscible with the polar solvent.

Abstract: A treatment system including a tension relief layer having a central elastic region coupled between a pair of opposing wings; a porous region within the central elastic region that allows for the passage of material from an incision or wound to an upper surface of the tension relief layer; and a conformable sealing layer configured to be applied over the tension relief layer and adhered forming a sealed space around at least a portion of the wound. At least a portion of each of the opposing wings have adhesive lower surfaces. The opposing wings are configured to be stretched away from one another towards a first tensile configuration and while held in the first tensile configuration adhered to skin on opposing sides of the incision or wound. Related devices, systems and methods are also described.

Abstract: PIVCs with extension sets can include one or more flow diverting features for maximizing the amount of flushing that occurs within the interior of the catheter adapter. These flow diverting features can therefore minimize the amount of residual blood, medicament, or other fluid that may exist within the catheter adapter after the PIVC has been flushed via the extension set. The flow diverting features may be in the form of structural modifications to the side port of the extension set, separate components that are contained within the side port or catheter adapter, integrated components within the side port or catheter adapter, other features or some combination of any of these features.

Abstract: A system for wound treatment includes adjunctive wound therapy devices and substrates comprising multiple first reservoirs and multiple second reservoirs. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.

Abstract: A combination wound drain and substance-delivery device includes a drain portion and a substance delivery portion. The drain portion and the substance-delivery portion include interior cavities that are separated from one another to prevent fluids and/or materials disposed within the interior cavities from mixing together. Each of the interior cavities includes one or more perforations that allow fluid communication between a wound site and each of the interior cavities. The device further includes a tip coupled to the drain portion that facilitates removal of collected waste from the drain portion. The device may include an attachment mechanism that helps secure the device when placed within a wound site.

Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.

Abstract: A system for applying reduced pressure to tissue includes a multi-lumen reduced pressure delivery tube having a proximate end, a distal end, a primary lumen extending through the conduit from the proximate end to the distal end, and an ancillary lumen extending through the conduit from the proximate end to the distal end. A vacuum pump is coupled to the proximate end of the primary lumen, and a reduced pressure adapter is coupled to the distal end of the reduced pressure delivery tube. The adapter includes channels to direct liquid away from the ancillary lumens and into the primary lumen.

Abstract: A device for protecting against microbial infection includes a cover having a concave interior surface and a convex exterior surface. The device further includes an adhesive flange for affixing the cover to a patient's skin. A membrane extends across at least a portion of the interior surface of the cover for retaining an antimicrobial compound between the membrane and the interior surface of the cover. The membrane is permeable to the antimicrobial compound so that the antimicrobial compound is released through the membrane over time.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: A system for subatmospheric pressure therapy in connection with healing a wound is provided. The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source. The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.

Abstract: A unit to treat inflammation of hemorrhoids, vulvo-vaginitis and similar conditions has a suppository and a multi-piece pad at a proximal end of the suppository. A first piece of the pad is adjacent the suppository so that medication can be applied concurrently to both. A second piece of the pad is a non-permeable layer disposed against the first piece. A third piece is an absorbent layer disposed against the second piece. A fourth piece is another non permeable layer disposed against the third piece. Medication from a container is applied to the unit through an adapter.

Abstract: A method and apparatus are disclosed for determining status of a canister of a topical negative pressure (TNP) system. The method includes the steps of monitoring pressure provided by a pump element of the TNP system, determining at least one characteristic associated with the monitored pressure and determining status of at least one parameter associated with a canister of the TNP system responsive to the determined characteristics.

Abstract: Described herein are compositions of keratin-based biomaterials together with halofuginone and methods of using thereof.

Abstract: Described herein are low protein concentration gelling compositions comprising keratin proteins.

Abstract: A method and apparatus are disclosed for delivering at least one agent to a wound site. The method includes the steps of providing a delivery tube having an outlet at a wound site, covering the wound site with a drape and introducing agent at an agent inlet port of the delivery tube. The agent passes along the delivery tube through the drape to the wound site. The agent can be a wide variety or mixture of fluids such as but not limited to pain relief medicament, anti-biotics, saline solution and/or hydrating fluid.

Abstract: Dressings, systems, and methods are disclosed that, in some embodiments, relate to treating a tissue site. In one embodiment, a dressing may include a manifold, a retention pouch, a sealing member, and a conduit interface. The manifold may be adapted to distribute reduced pressure to the tissue site, and the retention pouch may be adapted to retain and manage fluid extracted from the tissue site. The sealing member may cover the retention pouch and the manifold to provide a sealed space with the tissue site. The conduit interface may be in fluid communication with the sealed space and an exterior surface of the sealing member. The dressing may be utilized with a therapy device operable to control reduced pressure in the dressing and fluid flow over the sealing member.

Abstract: Systems and devices for treating a tissue site may include an interface adapted to provide a reduced pressure to a dressing. The interface may include a positive-pressure channel for delivering a positive pressure from a positive-pressure port to a positive pressure outlet. The positive-pressure channel may include a constricted portion configured to provide a pressure drop. The interface may additionally include a reduced-pressure channel adapted to deliver reduced pressure to the dressing that substantially corresponds to the pressure drop. The reduced-pressure channel may be fluidly coupled between the positive pressure channel and a side of the interface body adapted to face the dressing. Other systems and devices are disclosed.

Abstract: The invention disclosed comprises methods, apparatuses and compositions to treat acute and chronic wounds with pressures altered from atmospheric. The methods, apparatuses and compositions herein improve the performance of Altered Pressure wound therapy. The improvements also make the treatments more comfortable for the patient and the delivery of the treatment more convenient for clinicians. These improvements collectively result in improved efficacy, improved compliance, improved safety and improved clinical efficiency, while limiting clinical errors in treatment.

Abstract: Various embodiments of the present invention are directed to patches for medical devices. In various embodiments, an adhesive patch of a medical device may have selective areas with adhesive material of varying adhesion strengths. In other embodiments, an adhesive patch of a medical device may include adhesive material that may be activated by a catalyst to increase or decrease the adhesion strength of the adhesive material. In further embodiments, a medical device may include a pierceable membrane containing an agent, the pierceable membrane positioned to be pierced by a needle and to cause some of the agent to be carried to the user-patient.

Abstract: An all direction stretchable dressing article is disclosed. The article includes a first surface, a second surface, at least one layer of all directions stretchable polymer, and at least one layer of fibers affixed to at least a part of the polymer layer. The article further includes at least one type of curative material embedded or associated with at least one of the polymer layer or the fiber layer.

Abstract: A system that may be adapted to distribute reduced pressure to a tissue site may include a dressing and a sealing member. The dressing may include a manifold layer, a storage layer, and a plurality of retainers. The manifold layer may be adapted to be positioned proximate the tissue site, and the storage layer may be positioned proximate the manifold layer. The plurality of retainers may be disposed in the storage layer. Each of the retainers may define a fluid communication channel through the storage layer. The retainers may be adapted to substantially preclude deformation of the storage layer into the fluid communication channels. The sealing member may be adapted to cover the dressing and to provide a fluid seal between the sealing member and the tissue site.

Abstract: A method of providing moisture therapy to a subject by applying a moist therapy compress against a treated body portion. The moist therapy compress includes a fluid-permeable shell, a flexible backing fastened to the shell to define an enclosure, and a hydrophilic zeolite fill granules loosely contained within the enclosure. The therapy compress is exposed to a source of moisture to cause absorption of water into the a hydrophilic zeolite, and the moisture is delivered from the hydrophilic zeolite through the fluid permeable shell to the treated body portion.

Abstract: The present invention relates to a method for removing pigments from a pigmented section of a skin by puncturing the skin at the pigmented section, with a skin puncturing device which is provided with at least one needle, and then bandaging the punctured section with a suitable adsorbing pad. The pad contains one or more materials, such as saline, which will cause the pigments at the punctured section to migrate into the outer layer of the skin.

Abstract: A system for stimulating the healing of tissue comprises a porous pad positioned within a wound cavity, and an airtight dressing secured over the pad, so as to provide an airtight seal to the wound cavity. A proximal end of a conduit is connectable to the dressing. A distal end of the conduit is connectable to a negative pressure source, which may be an electric pump housed within a portable housing, or wall suction. A canister is positioned along the conduit to retain exudates suctioned from the wound site during the application of negative pressure. A controller for automated oscillation of pressure over time is provided to further enhance and stimulate the healing of an open wound. A power management motor control for varying pump drive frequency and managing a portable power supply is provided to increase battery life and improve patient mobility.

Abstract: The invention provides a homogeneous composition comprising a hemostatically effective amount of a charged oxide, wherein the composition has an isoelectric point, as measured in calcium chloride, below 7.3 or above 7.4. Typically, the charged oxide is selected from the group consisting of silaceous oxides, titanium oxides, aluminum oxides, calcium oxides, zinc oxides, nickel oxides and iron oxides. In some embodiments, the composition further comprises a second oxide selected from the group consisting of calcium oxide, sodium oxide, magnesium oxide, zinc oxide, phosphorus oxide and alumina. In a typical embodiment of the invention, the charged oxide is silaceous oxide, the second oxide comprises calcium oxide and the ratio, by molar ratio, of silaceous oxide to calcium oxide is 0.25 to 15. Optionally, the composition further comprises phosphorous oxide. Also described are methods of making and using such compositions.

Abstract: A dressing may be suitable for use with systems and methods for treating a tissue site. Embodiments of the dressing may include a base layer, an adhesive, a sealing member, a first wicking layer, a second wicking layer, and an absorbent layer. The base layer may have a plurality of apertures and may be adapted to cover the tissue site. The adhesive may be positioned between the sealing member and the base layer such that the sealing member and the base layer define an enclosure. The first and the second wicking layer may each be disposed in the enclosure with the absorbent layer positioned between the first and the second wicking layer. Other dressings, systems, and methods are disclosed.

Abstract: A wound dressing garment is provided. The wound dressing garment includes a wearable garment including a portion having a hole configured to receive a wound dressing therein in combination with the wound dressing. The wound dressing includes a border connecting the wound dressing to the wearable garment where the border extends around the perimeter of the hole to locate the wound dressing therein. The wound dressing may include one or more additional layers including a hydrogel layer. A method for treating wound or preventing bed sores using the wound dressing garment is also provided.

Abstract: The present invention relates generally to the field of hemostasis, including methods, compositions, and devices that can be employed to treat wounds. More specifically the present invention relates to hemostatic compositions that reduce the need for, and cost of, nursing care of patients with chronic wounds by reducing the frequency of wound dressing changes.

Abstract: The invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade at a site in a human or animal in need thereof, the device comprising a fibrillar collagen matrix; and at least one drug substance selected from the group consisting of amino amide anesthetics, amino ester anesthetics and mixtures thereof, the at least one drug substance being substantially homogeneously dispersed in the collagen matrix, and the at least one drug substance being present in an amount sufficient to provide a duration of local analgesia, local anesthesia or nerve blockade which lasts for at least about one day after administration.