Abstract: The present invention relates to a bag (1) for packaging a biological substance, such as animal semen, which is formed by two plastic walls (10, 11) assembled so as to define a pouch (P) for receiving said substance and that comprises a line (15) communicating with said pouch (P) a line for filling the same, this bag comprising in addition at least one pair of openings (3, 4) located on both sides of said line (15), in order to get hung, via these openings, to fingers that are complementary to a supporting device. This bag is characterized in that at least one of these openings (3, 4) has an oblong shape, extends perpendicularly to said line (15), and comprises an area forming a hard spot. The invention relates also to a strip formed by juxtaposing such bags (1), and an assembly comprised of a bag and a hanging support.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: A device for injection, comprising a body (1) provided with a first channel (2) for conveyance of a first medical substance and a first connecting component (3) having a first port (4) for introduction of a first medical substance into said first channel (2), the connecting component (3) being connectable to an external unit, and a second channel (5) for conveyance of a second medical substance and a second connecting component (6) having a second port (7) which can be opened by means of an injection component for injecting a second medical substance into said second channel (5), and provided with a third connecting component (8) being common to the first and the second channels (2, 5) and having at least one third port (9) for conveying medical substances out from said first (2) and second (5) channels, the first (3), second (6) and third (8) connecting components and the body (1) being designed as an integrated unit.

Abstract: A port assembly includes a housing with an opening and a bore therethrough, a slit septum disposed in the opening to control access through the opening, a base joined to the housing and having a membrane attached thereto, a perforator having a first end abutting the slit septum and a second end aligned with the membrane, and a resilient member disposed between the perforator and the base. The perforator has first and second lumens, the first lumen extending between the first and second ends of the perforator and the second lumen extending between a point between the first and second ends and the second end. The perforator also has a seal disposed about the first lumen at the first end of the perforator, and a valve associated with the second lumen to limit flow of fluid through the second lumen in the direction of the second end.

Abstract: The present invention relates to a first medical device (1, 100) configured to permit connection to a second medical device (3). The medical device (1, 100, 200) comprises a guiding track (12) for receiving a lock protrusion (4). The guiding track (12) comprises a surface (16) having a lock edge (15) extending between a first and a second level (H1, H2). The lock edge (15) extends in a smooth curvature between the first and the second level (H1, H2), the curvature of which is a function of at least of radius (Ra). The medical device (1, 100) may comprise a neck element (11) with at least one guiding track (12) for receiving a lock protrusion (4) of a second medical device (3) or optionally the medical device may comprise a sleeve member (202) which comprises the guiding track (12). The present invention provide for a connection site which enables a smooth lock but especially a smooth unlock motion of the second medical device being connected.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: The present invention is a multi-dose device for insertion into a vial containing a fluid. The device has a double-nested needle inserter for insertion into the vial. Opposite the double-nested needle inserter is an air opening stack and a Luer lock port.

Abstract: A vial adaptor configured to be attached to a wide range of vial sizes, the adaptor being configured to penetrate the vial seal so that the contents of a vial can be removed. The vial adaptor can have a body portion, a penetrating portion projecting from the body portion and configured to be inserted through the seal and positioned within an interior space of the vial so that the contents of the vial can flow through an opening in the penetrating portion, an interface portion supported by the body portion that is connectable to a syringe or other medical implement, at least one deflectable tab configured be bendable by hand or to bend in response to contact with the vial. The vial can also have a filtered air vent to allow air to fill the vial as the contents thereof are being removed.

Abstract: The present invention relates to a process of fusion-bonding a plastic film (8a, 8b) to an object to be fusion-bonded such as a port member (16) in manufacturing a drug bag, and relates to a drug bag. The present fusion-bonding process comprises steps of disposing a heat generation element generating heat by absorbing infrared laser, on an opposite surface (8c) of the plastic film (8a, 8b) from the port member (16), or between the port member (16) and the plastic film (8a, 8b), pressing a press member (30a, 30b), which allows infrared laser to be transmitted therethrough, from a side of the plastic film (8a, 8b), and irradiating the infrared laser (L) to the heat generation element (24a, 24b) through the press member (30a, 30b).

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

Abstract: A tubing set is disclosed including a first line having first and second ends, a bag spike at the first end configured for connection to a source of infusate, and a connector at the second end configured for connection to a blood line. The first line has a pumping portion for engagement with an infusate pump. The tubing set includes a second line having first and second ends, the first end being attached to the first line between the first line pumping portion and the first line second end and the second end being configured for connection to the first line between the first line first end and the first line pumping portion. The second line second end is configured for connection to the first line by a dual lumen spike.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: An apparatus for removal of premixed drugs or reconstitution of lyophilized drugs and for the injection of the reconstituted drug into the patient. The apparatus includes a syringe assembly and an adapter assembly that can be removably connected to a medicament container containing a premixed drug or lyophilized medicament. The syringe assembly of the apparatus includes a liquid chamber between the forward end of the body portion and the piston and a syringe cannula assembly. The syringe cannula assembly, which can be removably interconnected with the body portion, comprises a cannula support and a hypodermic needle sealably connected to the cannula support. The adapter assembly comprises an adapter preferably molded from a moldable plastic that includes a top wall, an adapter cannula connected to and extending from the top wall and a variety of connectors connected to the top wall for removably interconnecting the adapter with the medicament container.

Abstract: Methods for making an using convenience kits for hazardous drug (liquid) transfer from vials to syringes and target IV connectors. The following methods for making and using are disclosed: (1) Using a conventional plastic bag as a vial and vial adapter enclosing shroud. (2) Using of a flange (i.e. latch arm) free vial adapter which may, therefore, be used for a large variety of vial sizes. (3) Providing a seal about an access hole through which a vial adapter dispensing portion provides a closed fluid dispensing pathway. (4) Using the shrouding bag and an associated elastic band to provide desired stability of a spiked vial. (5) Accessing, measuring and transferring vial contents directly from a vial to a target IV container.

Abstract: The invention relates to systems and methods for collecting the content of IV lines that otherwise would be spilt in a hospital environment. In one general aspect the system includes an intravenous tubing system to prevent spillage of fluids. The IV tubing system includes intravenous tubing and a purge bag. The intravenous tubing includes a first end configured to attach to a fluid container and a second end having a connector. The purge bag includes at least one port, such as a needle-free valved port, configured to receive fluids from the intravenous tubing. The purge bag optionally contains a second port is configured to let air into or out of the purge bag with a closing means that may be a needle-free valved port. The purge bag can be packaged separately from the IV tubing set and the package can be opened at the time of use.

Abstract: This disclosure relates to drug vial spikes, fluid line sets, and related systems. In some aspects, a fluid line set includes a frame, multiple spikes extending from the frame, and multiple fluid lines connected to the frame. The frame is configured to hold the fluid lines in a spaced apart configuration.

Abstract: A fluid dispenser device comprising a body provided with a dispenser orifice, a reservoir containing at least one dose of fluid being disposed statically in said body, said reservoir being closed in sealed manner by two stoppers, a first stopper and a second stopper the fluid being disposed in a fluid chamber, said device further comprising opener means for opening said first stopper, said opener means being disposed statically in said body, actuator means being connected to said second stopper, the actuation of said second stopper creating pressure in the fluid chamber; said pressure displacing and/or deforming said first stopper towards said opener means, and then fluid is expelled through said open first stopper towards said dispenser orifice, a spray profile being provided downstream from said dispenser orifice, the device further comprising precompression means.

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

Abstract: In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. In some embodiments, an anti-reflux valve is positioned within the extractor channel. The anti-reflux valve can be configured to impede or obstruct fluid returning to a fluid source after withdrawal of the fluid from the fluid source.

Abstract: A vial enshrouded or contained in a protective covering which prevents emission of radiation form the vial contents, shielding the environment and personnel from irradiation. The vial optionally has a V-shaped bottom to allow withdrawal of a maximal amount of the fluid without inverting the vial. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends in to the V-shaped bottom. The vial access adapter may be vented or non-vented.

Abstract: A method for retaining aerosols when accessing a sealed vial is disclosed. The method includes the steps of piercing the vial seal with a sharp cannula having a medicament lumen and a vent lumen, introducing a liquid through the medicament lumen into the vial, and conducting gas out of the vial through the vent lumen and a vent port to the atmosphere. The method also includes the steps of blocking the passage of non-dispersed liquid out the vent lumen at a first filter device comprising pores having a diameter in the range of 0.2-3.0 microns, absorbing liquid dispersed in gas at a second filter device, and inhibiting the passage of bacteria at a third filter device having a pore size smaller than 0.2 microns.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: The invention concerns a piercing member protection device, a kit of a piercing member protection device, a first and second fluid container and a method a method for transferring a fluid between a first and a second container using a piercing member protection device. The piercing member protection device comprises a protection chamber to protect at least the tip of a piercing member. The piercing member protection device further comprises a first and a second member arranged to each other.

Abstract: A one-piece bottle is provided, the bottle having a capacity that does not exceed 10 ml, containing enteral feeding material, and having a top end with a threaded section and a bottom end comprising a funneled connector port; and a threaded cap dimensioned to mate with the threaded section of the one-piece bottle; wherein the funneled connector port connects to an enteral feeding assembly; wherein the threaded cap provides a leak proof seal such that there is no exposure point until it is used for feeding, thereby preventing contamination.

Abstract: The kit for suppressing drug craving K is used by connecting an instrument for suppressing drug craving 1 to a syringe 2 and the instrument for suppressing drug craving 1 has a cylindrical housing 11, a pouch 12 provided in the housing and containing pseudo-blood B and a connecting member 13 with which the distal end of a syringe is coupled and which cause the syringe to communicate with the interior of the pouch. When the syringe accommodating pseudo-drug M is connected to the instrument and the plunger is moved forward (pseudo-priming), the pseudo-drug M flows into a pouch and the pouch inflates (FIG. 2(b)), and if the plunger 4 is pulled back from this condition, the pouch 12 deflates and the pseudo-blood B flows back from the pouch 12 to the syringe 2 (flashback) (FIG. 2(C)).

Abstract: Anti-vacuum-lock assemblies for preventing vacuum lock when withdrawing medicinal fluid from a vial comprising a multi-finger bung-type stopper in which the fingers are of sufficient length to protect a collapsing or expanding bladder in the vial from being punctured by the hypodermic needle. In a first embodiment the vial includes one or more side or bottom wall holes to permit ambient air to enter in the space between an internal bladder containing a medicinal fluid and the inner wall of the vial. In another embodiment, an expanding bladder in communication with the exterior expands as fluid is withdrawn from the vial. In a third embodiment a fluted collar is inserted in the vial neck to provide air passages into the space between the medicinal fluid-containing bladder and the interior wall of the vial. The collapse of the medicinal bladder or expansion of the compensation bellows or bladder prevents vacuum lock.

Abstract: The present invention provides an enteral feeding set comprising tubing adapted for fluid flow therethrough and further adapted to be engaged by a pump unit, a valve mechanism in direct communication with said tubing, said valve mechanism being adapted to be engaged by said pump unit, and a feeding set indicator for permitting identification of the functional configuration of said administration feeding set by said pump unit, characterized in that said tubing comprises at least two inlet tubes on an upstream side of said valve mechanism and a single outlet tube on a downstream side thereof and wherein said inlet tubes each include a connector for connecting said tube to a supply of fluid at a connection end thereof, each of said connectors being of like form but visually distinguishable for indicating to a user which supply of fluid each connector should be attached thereto.

Abstract: A inert sampling needle is provided for piercing a septum of a vial containing a sample. The sampling needle includes a hollow rigid support member having an inner wall, an outer wall, and a septum-piercing end. The sampling needle also includes a sheath member affixed to the rigid support member. The sheath member covers the septum-piercing end of the support member, the inner wall, and at least a portion of the outer wall adjacent the septum-piercing end to isolate the support member from the sample. Preferably, the sheath member is formed of polyetheretherketone and is affixed to the rigid support member by heat fusing. A method of forming, and a method of using the inert sampling needle is also disclosed.

Abstract: A process for preparing a lyophilized material, providing a container having a penetrable envelope and containing the material in a carrier liquid, whereby the penetrable region is penetrated with a penetrator which provides a conduit through the envelope, and the carrier liquid is evaporated out of the container via the conduit, after which the penetrator is withdrawn.

Abstract: A system for transferring solutions from a first cartridge into a second cartridge comprises a cartridge holder, a plunger driver, and a cartridge connector. The cartridge connector carries a transfer needle and an exhaust needle. The cartridge holder positions the first cartridge against the cartridge connector so that the transfer needle penetrates the first cartridge septum. The second cartridge is removably inserted into another end of the cartridge connector so that both the transfer needle and the exhaust needle penetrate the second cartridge septum. The plunger driver is disposed to advance a plunger on the first cartridge to transfer solution from the first cartridge into the second cartridge thus displacing solution from the second cartridge through the exhaust needle. The cartridge connector includes a sealed interior waste chamber for receiving the solution from the second cartridge.

Abstract: A female piercing member protection device for connection with a male connection part, and a method for connecting the device to a male connection part. The device includes an outer casing and a connection member at least partly enclosed in the outer casing. The outer casing is moveable between first and second positions. In the first position, the connection member is substantially locked from movement along the longitudinal axis A, and in the second position the connection member is able to move along the longitudinal axis A. The device also has an activated position and an inactivated position. When the outer casing is in the second position, a deformable locking device is prevented from deformation by the outer casing to prevent disengagement of the male connection part. A secure piercing member protection device significantly minimizes the risk for a user to be exposed to contaminants and the piercing member itself.

Abstract: Provided a port member for an infusion solution bag that is capable of suppressing occurrence of gaps or wrinkles in a sealed portion in a manufacturing process, and preventing damages to resin sheets of a bag body during storage or transportation. A port member for an infusion solution bag includes a tubular body portion having one end sealed by a plug member structured to enable a hollow needle to be pierced into the plug member, and a tubular to-be-sealed portion continuously formed with an other end of the body portion and having an inner space communicated with the inside of the body portion, the to-be-sealed portion being held between and sealed to end portions of resin sheets overlapped together to form a bag body having an inner space for accommodation of at least a medicine, in which the to-be-sealed portion thus sealed has a radially flattened shape.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A filling system for syringes utilizing short needles to be filled from a vial having a thick septum is described. The system may be useful in any situation where the septum or vial stopper of a medication container is thicker than the usable length of the needle on the delivery device. Preferably, the syringe is filled just prior to use. The short needle includes an optional limiter which only permits a certain predetermined length of the needle cannula to protrude beyond the limiter a distance which limits penetration of the needle tip into both the skin and a vial stopper. The system and adapter may be useful for needles having a protrusion distance from approximately 0.5 mm to 3 mm, or any needle with a protrusion length shorter that the thickness of a septum to be accessed. Furthermore, a device is provided with shielding capabilities to shield the needle of the device.

Abstract: A system for removing or tranferring a pharmaceutical product from a reservoir including an ampoule with a moveable piston therein and an adaptor which includes, generally along a longitudinal axis, a reservoir connector and an ampoule connector for coupling to the ampoule, wherein the ampoule connector includes at least one locking mechanism which, in a side wall, includes a resilient element generally corresponding to a portion of the side wall which extends along the periphery thereof and, at opposing ends, merges with the side wall.

Abstract: A perforable closure for a container, is provided with at least a annular portion (2) fit to joint the container and connected to an end portion (3), perforable by means of a perforator (P) of an outflow or the like. At least the annular (2) and end (3) portions of said closure (1) are integral.

Abstract: A non-coring needle that includes a sharpened and hardened tip having a tapered back region against which a length of tubing is pressed and welded, brazed or soldered. A Luer Lock hub may be attached to the other end of the tubing.

Abstract: A multiple chamber medical fluid bag includes: (i) a flexible enclosure; (ii) a first fluid chamber formed in the enclosure; (iii) a second fluid chamber formed in the enclosure; (iv) the first fluid chamber and the second fluid chamber separated by a frangible seal; and (v) an access port connected to the enclosure, the port imbedded into the enclosure so as to completely surround the access port, the enclosure further configured such that the frangible seal is broken to uncover the access port.

Abstract: The present invention provides a one-piece bottle containing enteral feeding material and having a top end with a threaded section and a bottom end comprising a funneled connector port; and a threaded cap dimensioned to mate with the threaded section of the one-piece bottle; wherein the funneled connector port connects to an enteral feeding assembly; wherein the threaded cap provides a leak proof seal when tightened on the threaded section of the one-piece bottle, and allows venting of the bottle when loosened.

Abstract: A reconstitution assembly includes: a flexible bag containing a diluent; a drug vial containing a drug; a reconstitution device further comprising: a first sleeve connected to the first container; a second sleeve connected to the second container, the second sleeve being associated with the first sleeve and movable axially with respect thereto from an inactivated position to an activated position; a piercing member positioned in the sleeves, the piercing member providing a fluid pathway between the bag and vial when the sleeves are in the activated position.

Abstract: The closure device (500) comprises a stopper (501) made of elastomer and a cover (502) suitable for covering both the neck (12) of a container and stopper (501) in place in said neck (12). The cover (502) is made of plastics material and comprises a ring (503) and a drive member (504). The ring (503) may surround the stopper (501) and the neck (12) in the mounted configuration, the ring being provided with locking means (503G) for locking on the neck (12). The drive member (504) may be mounted on the ring (503) in arbitrary angular orientation about a central axis (X503) of the ring. The drive member is provided with an annular edge (505D) suitable for being engaged between an outer skirt (503A) of the ring (503) and at least one tab (503G) forming locking means and extending radially towards the central axis (X503) of the ring from the skirt (503A).

Abstract: An object is to provide a communicating needle of simple construction which is attached to a medical infusion bag to connect two or more containers in fluid communication with each other. The communicating needle for connecting two or more containers to communicate includes a tip having an outlet opening formed thereon and a seal member integrally formed with the communicating needle to seal the outlet opening. The seal member readily comes off the communicating needle when acted upon by an external force, causing the outlet opening to open. The communicating needle may be covered by a seal body.

Abstract: To provide a drug solution preparing kit which can be handled with ease in a substantially aseptic manner, and has no risk that a leakage of a drug solution such as a splash and a dispersion of an aerosol to an ambient environment occurs upon preparation of the drug solution There is provided a drug solution preparing kit including a pre-filled syringe and a transfusing tool, wherein the pre-filled syringe includes a sealing member which seals the tip end and can not be removed from the tip end, and that the transfusing tool includes a one-way valve which can discharge only gas from the system in an irreversible manner, and a filter which is provided so as to adjoin to the second communication channel with respect to the one-way valve.

Abstract: The invention relates to a closing cap for containers that are filled with medical liquids. The closing cap includes removal and injection sites. The removal site has a first opening for removing the medical liquid and is obturated by a first pierceable self-sealing membrane. The injection site includes a second opening for injecting an additive and is obturated by a second pierceable self-sealing membrane. The first and second membranes are configured differently.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: Embodiments of the invention relate to a transfer device for a container whose interior is under negative pressure and which is closed by means of an elastic stopper. The device has a receiving cap and a piercing mandril for piercing the stopper. Relative to its direction of piercing, the piercing mandril is provided with a front piercing portion and with a rear sealing portion which is of greater diameter. In the position in which a bead of the container is inserted into the receiving cap, the sealing portion contacts the stopper. In this way, a tear in the stopper, which tear has been formed by eccentric application of the device onto the container, can be sealed off.

Abstract: A system for removing or transferring a pharmaceutical product from a reservoir including an ampoule with a moveable piston therein and an adaptor which includes, generally along a longitudinal axis, a reservoir connector and an ampoule connector for coupling to the ampoule, wherein the ampoule connector includes at least one locking mechanism which, in a side wall, includes a resilient element generally corresponding to a portion of the side wall which extends along the periphery thereof and, at opposing ends, merges with the side wall.

Abstract: Systems and methods to reduce bioburden on at least a portion of a fluid transfer port include supplying a dose of radiation to the portion in optical communication with at least one source of radiation. In an illustrative example, a medical container, such as a vial or IV bag, receives a dose of ultraviolet (UV) energy substantially at a predetermined region of a fluid transfer site. In some examples, such a sanitization process may precede a fluid transfer operation in which a fluid is transferred into or out of the medical container by passing through the sanitized region. Such fluid transfers may be used in automated or semi-automated pharmaceutical processes, such as drug reconstitution. Various embodiments may further include one or more seal assemblies, each seal assembly having an aperture through which the radiation dose is supplied from the source to a controlled region on the fluid transfer port.