Abstract: A transfer guard for use by an individual for transferring contents from a supply container into a receiver container includes a supply adapter, a receiver adapter, a support structure and a fluid conducting element. The supply adapter connects the supply container to the transfer guard, and the receiver adapter connects the receiver container to the transfer guard. The support structure couples the supply adapter with the receiver adapter, and supports the fluid conducting element which, passes through the supply adapter and the receiver adapter. The fluid conducting element provides a passage for the contents to transfer from the supply container into the receiver container. The fluid conducting element also includes at least one pointed end that is substantially protected by the transfer guard from contact with the individual.

Abstract: The present invention provides a reconstitution device (10) for placing a first container (12), such as a liquid container (e.g. flexible container or syringe), in fluid communication with a second container (14), such as a drug vial. To this end, there is provided a connector device (10) for establishing fluid communication between the diluent container (12) and the drug vial (14). The connector device (10) has a first sleeve member (32) having a first end (36) and a second end (38). The first sleeve member (32) has at the first end (36), a first attaching member (30) adapted to attach to the liquid container (12). The connector device (10) also has a second sleeve member (34) having a first end (48) and a second end (50). The second sleeve member (34) is movable axially with respect to the first sleeve member (32) from an inactivated position to an activated position. The second sleeve member (34) has a protuberance (66) on an inner surface of the second sleeve member (34).

Abstract: The present invention relates to a safety vacuum syringe for blood sampling conformed to ergonomics, mainly comprises: a hollow barrel, the barrel has a reduced inlet disposed on the top end thereof and a guiding slit disposed at the flank side thereof. A reduced lining tube is installed in the barrel, an eccentric reduced portion is eccentrically disposed on the top end of the reduced lining tube and has an opening at the lower end thereof, the eccentric reduced portion is wedged and fixed in the reduced lining tube and projects out of the reduced inlet. Besides, a needle head is fixedly covered on the eccentric reduced portion, a through guiding hole is disposed at the center of the eccentric reduced portion to position a type needle therein, a lower needle tip of the needle is positioned at the central axis in the reduced lining tube, a press plate is connected to said reduced lining tube at the outer flank side thereof and is positioned in the guiding slit.

Abstract: A plasma-collecting devise comprises a blood-filtering element having a blood-drawing needle and a communicating needle, a vacuum blood-drawing tube, and a contracting and expanding element connecting the blood-filtering unit and the vacuum blood-drawing tube. The device enables blood drawing from blood vessel and blood filtering continuously to obtain plasma.

Abstract: A bottle having a sterility seal and a method for producing same are disclosed. The bottle, which can be configured to retain a medicament in powder or tablet form, features a protective cap configured to engage a transfer assembly associated with the bottle. The cap includes one or more raised ridges on an interior surface engageable with a portion of the transfer assembly. A band or layer configuration of a sealing material such as silicone is applied to the transfer assembly prior to insertion of the cap thereover. As the cap comes into surface contact with the sealing material, the ridges cause the material to “roll up” into a toroidal O-ring configuration, thereby forming a seal between the cap and the bottle adapted to the dimensional variations of those components.

Abstract: A transfer guard for use by an individual for transferring contents from a supply container into a receiver container includes a supply adapter, a receiver adapter, a support structure and a needle. The supply adapter connects the supply container to the transfer guard, and the receiver adapter connects the receiver container to the transfer guard. The support structure couples the supply adapter with the receiver adapter, and the needle passes through the supply adapter and the receiver adapter. The needle is attached to one of the adapters for support and provides a passage for the contents to transfer from the supply container into the receiver container. The needle also includes at least one pointed end that is substantially protected by the transfer guard from contact with the user.

Abstract: A transfer set assembly for transferring fluids between a first container, such as a conventional medical vial, having a sealed open end and a second container such as a conventional IV infusion bag. The transfer set includes a collar having a proximate tubular end portion for securement to the container, a needle cannula and holder assembly, which is telescopically received in a distal tubular portion of the collar, and a closure including a tubular body portion having an open proximate end which is telescopically received over the needle cannula and holder assembly and the distal tubular portion of the collar, a closed distal end portion and an inner tubular portion which is integral with the closed distal end. The inner tubular portion includes a free end having spiral camming surfaces which mate with spiral camping surfaces on the inside surface of the tubular distal portion of the needle cannula holder.

Abstract: A blood extraction device has a holder with a hollow needle cannula anchored therein. A rear end portion of this cannula is surrounded by a closed-end elastic hose like valve rubber tube with an air gap between the tube and the cannula. With a minimum of effort and cost a reliable anchorage of the valve rubber tube in the holder is obtained by pressing a clamping member within the holder against the exterior of the valve rubber tube and thereby plastically deforming this clamping member.

Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first end and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container; and a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable axially with respect thereto from an inactivated position to an activated position. A second attaching member is provided on the second end of the second sleeve and adapted to fixedly attach the second sleeve member to the second container. First and second piercing members are also provided projecting from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container.

Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable with respect thereto from an inactivated position to an activated position, the second sleeve member having at the second end a second attaching member adapted to attach the second sleeve member to the second container. First and second piercing members project from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container, and the first and second piercing members are independently hermetically sealed.

Abstract: A system, a method and administration lines are provided for self-priming of a solution delivery system. The administration lines are arranged such that resultant forces acting on the lines create different forces applied on each lumen resulting in solution flowing in one of the lumen undergoing a higher isostatic pressure. The lumens forming the administration line may be formed from concentric tubings or formed from separate tubings extending varied lengths into the solution container. As a result, automatic priming of the administration line and the solution delivery system is provided.

Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first end and a second end and a sidewall defining a chamber, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and is movable axially with respect thereto from an inactivated position to an activated position. A second attaching member is positioned on the second end of the second sleeve and adapted to attach the second sleeve member to the second container. A piercing member positioned in the chamber and projecting from one of the first and second sleeve members is provided for establishing a fluid flow path from the first container to the second container. The piercing member is hermetically sealed.

Abstract: A disposable needle having individual, spring biased, first and second retractable, open protective sleeves. The first retractable sleeve covers the needle end employed to extract patient blood and the second retractable sleeve covers the needle end that transfers blood to a collection tube. Each sleeve is provided with diametrically disposed slits receiving diametrically disposed ear extensions on the needle support. A support segmented housing maintains the sleeves and needle into a unitary structure. Detents are disposed on the end of the first sleeve that telescopingly receives the open end of the second sleeve. In use, the first sleeve is manually retracted and the detents secure the sleeve in retracted position. A tubular support on the opposite end of the segmented housing receives a blood collection tube therein that forcibly retracts the second sleeve and permit penetration of the blood collection tube.

Abstract: The present invention relates to a needle mounted in a needle hub fitting onto an injection device from which preset doses of a medicine from a cartridge accommodated in the device is administered through the needle comprises a back needle penetrating a closure membrane of the cartridge and a free injection part shorter than 9 mm, the outer diameter of the needle and the diameter of its bore complying with one of the conditions: a) the outer diameter is smaller than 0.320 mm and the diameter of the bore is larger than 0.165 mm, or b) the outer diameter is smaller than 0.298 mm and the diameter of the bore is larger than 0.133 mm.

Abstract: Device (1) for sealing a closed container (2) comprising a neck (3), the opening (3a) of which is plugged, and provided with an external annular lip (3b), the device firstly comprising an internal cap (5) for fitting coaxially over the neck (3) of the plugged container (2), comprising catching teeth (6) distributed angularly about the axis (7) of the cap, each teeth having a radially outwards elasticity starting from a position (FIG. 3) of snap-fastening under the annular lip (3b), secondly, means (9) of access, which are arranged on the cap (5), and thirdly, an external sleeve (10) for sliding coaxially against and on the outside of the catching teeth (6), including a circumferentially continuous band (10a) provided along one of its edges with an internal annular ridge which may be continuous or discontinuous, for snap-fastening under the rim (6a), when the said sleeve (10) is in the fitted position.

Abstract: An injection device which includes a container constructed and arranged to contain a medicament, a medicament disposed within the container, a seal constructed and arranged to seal the medicament in the container, and a hypodermic needle. The hypodermic needle has a tubular, elongated, generally cylindrical wall defining an internal longitudinal bore extending longitudinally through the cylindrical wall along a longitudinal axis. The cylindrical wall forms a forward end defining a forward opening of the bore and a rearward end defining a rearward opening of the bore, the cylindrical wall having a laterally facing opening spaced closer to the rearward opening of the longitudinal bore than the forward opening of the longitudinal bore. The longitudinal bore is restricted at a position between the rearward opening and the laterally facing opening.

Abstract: An outer tube having a double-ended needle accommodated therein upwardly and downwardly slidably is hermetically, removably but fixedly joined to an opening seal portion of a dissolving liquid container. An inner tube having a medicine-containing vial accommodated therein in an inverted state is joined to an upper end of the outer tube so as to be movable from a joined position of shallow fit to a joined position of deep fit. The joint between the outer and inner tubes is provided with a seal ring for holding the interior of the tubes airtight and a restraining mechanism for holding the inner tube in the joined position of shallow fit. The medicine container thus constructed is excellent in impact resistance and shakeproofness for transport and storage, usable by a facilitated mixing procedure for preparing a medicinal solution, simple in overall structure and disposable as separated into components after use.

Abstract: Safety device for taking samples and performing infusions which comprises: a grip end provided with a coupling for connection to a fluid supply duct; a delivery end for a container for collecting fluid; a double-tip needle in which the tip proximal with respect to the supply duct is directed toward the grip end and the distal end is directed toward the delivery end; a needle support engaging an intermediate portion of the needle and movable from an inactive position to an active position toward the grip end in order to cause the proximal tip of the needle to penetrate the supply duct; elastic return means for said support; and an element for abutment at the delivery end for acting as a locator for a collection container, which moves with respect to the needle between a retracted needle protection position and a protruding position for insertion on the needle in order to expose its distal tip and simultaneously insert it in the collection container.

Abstract: A fluid delivery system including a vial having an opening for containing a dry medicament, a container having an opening for containing a solution, upper and lower, pierceable plugs for hermetically sealing the openings of the vial and the container, respectively, a capsule having upper and lower ends, and a sliding member slidably disposed in the capsule and having a double-pointed cannula providing with upper and lower needles. The container is slidably inserted into the capsule from the upper open end of the capsule and the vial can be detachably and fixedly connected to the lower open end of the capsule. When container is pushed downward, the lower needle of the cannula is firstly pierced and inserted into the plug of the vial so that the cannula is communicated with the medicament vial and then the upper needle of the cannula is pierced and inserted into the plug of the container so that the vial and the container are communicated to each other through the cannula.

Abstract: An adapter for interconnecting in fluid communication a first connection site and a beneficial agent container having a closure. The adapter includes a plate having first and second connection site sides. A wall extends from the plate from the second connection site side and constructed to surround only the closure. This allows containers having varying sized bodies to be received. A cannula structure is rigidly secured in the plate and defines a flow path extending through the plate. The adapter can be provided in an assembly with the beneficial agent contained or in a drug delivery system.

Abstract: A device is disclosed which provides direct and effective incorporation of material (such as medicine) from a separate container into the contents of a liquid dispensing device. The device has a hollow sleeve extending outwardly, an openable closure, a securing member which engages a mating member on the container, and a conduit (such as a needle) to provide fluid communication between the device and the container, with the fluid communication occurring upon attachment of the container to the device. The device can also provide for attaching the separate container to the dispensing device but without initially establishing liquid communication between the two.

Abstract: An injector for delivering fluid to a preselected internal target tissue while avoiding fluid exposure to surface tissue. A needle housing assembly is concealed within a cartridge having a puncturable end cap and an ampule is also disposed within the cartridge separate from the needle housing assembly. The cartridge has a cylindrical bore which widens at one end such that the needle housing assembly which has walls while located within the narrower portion of the cylindrical bore prevents the ampule from being punctured by a hollow injection needle supported by the needle housing assembly. When the ampule is propelled toward the needle housing assembly with a plunger, the needle housing assembly enters the widened portion of the cylindrical bore, allowing its walls to be separated such that the hollow injection needle extends into the ampule allowing the fluid to be delivered from the ampule through the hollow injection needle to the internal target tissue.

Abstract: A fluid container comprises a drug container, a deformable solvent container, a double-pointed hollow needle having a sharp piercing edge at each end and being arranged between the drug container and the solvent container, a guide capsule with a cap rotatably mounted thereon, and a means for converting rotary motion of the cap to a linear motion of the drug container to push the drug container toward the solvent container in cooperation with the cap and the guide capsule so that a fluid communication is made between two containers through the needle.

Abstract: A hypodermic syringe has a syringe barrel with a distal end and a passage therethrough communicating with a fluid-receiving chamber in the syringe barrel. A barrier extends across the passage to isolate the fluid in the chamber. A needle cannula is mounted to a needle hub slidingly engaged at the distal end of the syringe barrel. The needle cannula includes a proximally facing point for piercing the barrier in the passage to the chamber of the syringe barrel. A needle shield is mounted to the distal end of the syringe barrel, and cam means are provided for cam-guided rotational movement between the needle shield and the syringe barrel. The cam shape causes the needle shield and the needle cannula to move proximally for initially piercing the barrier and then to move distally to enable separation of the needle shield.

Abstract: A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When a flexible extension of the piston is coupled with a tubular plunger, and an adaptor cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston may have an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded.

Abstract: A double-sided needle assembly includes an insert needle for inserting into a vessel; an afflux needle for supplying pharmaceutical liquid in an injector to the insert needle; and a luer member. The member connects the insert needle with the afflux needle through a space defined between the ends of the needles in the member, and holds the insert and afflux needles to fit to the syringe of the injector under pressure. The confirmation of the insertion of the insert needle into the vessel is accomplished by observing the space of the luer member.

Abstract: A blood collection and/or injection device includes a double-ended medical needle including a cannula having opposite pointed ends, a hub fitted over the cannula, a rubber sheath optionally fitted over an end portion of the cannula, a cylindrical holder having an opening defined in one end thereof, the end portion of the cannula which is optionally covered with the rubber sheath being adapted to be inserted into the opening with the hub held in the opening by the cylindrical holder, and an evacuated blood collection tube or syringe adapted to be inserted into the cylindrical holder through an opening defined in the opposite end of the cylindrical holder and pierced by the end portion of the cannula. The hub has spreading teeth, and the cylindrical holder includes a holder casing having chuck teeth spreadable radially outwardly by the spreading teeth of the hub.

Abstract: A valve insert includes an elongated cannula with first and second sharp ends. First and second elongated, flexible, elastomeric covers are respectively disposed over the first and second sharp ends of the cannula. Each cover is secured to an intermediate part of the cannula and is made of a material penetrable by the sharp ends of the cannula as the cannula moves longitudinally relative to the covers. The insert is mounted in an elongated bore through a valve body so that when a hypodermic syringe nozzle is inserted inito one end of the bore, the cannula and covers are displaced longitudinally, causing the sharp ends of the cannula to pierce the covers and open the cannula for fluid flow.

Abstract: A medical fluid administration set is disclosed which may be used for the passive reconstitution and delivery of a drug or other beneficial agent with liquid flowing through the administration set. A receptacle mounted in the administration set is adapted for receiving a cartridge containing the beneficial agent. Also disclosed is an adapter for connecting the cartridge and the receptacle and an air flask within the administration set.

Abstract: The blood collecting tube of the present invention has a tubular body that is opened at one end and closed at the other end and a sealing member which is bonded to the peripheral edge of the opening of the tubular body so as to seal this opening.

Abstract: A kit and process for reconstituting human bone and/or related tissue is disclosed. The kit comprises a pre-formulated sterilized reconstitution medium and double ended transfer needle.

Abstract: Disclosed is a fluid container having a flexible bag containing a diluent and having a closing film at its upper end, a capsule connected to the flexible bag, a drug container held in the capsule and a communicating member for communicating the flexible bag with the drug container. The communicating member has a double-edged hollow needle having a hub in the midway thereof, and a controlling mechanism for controlling the order of communication in such a manner that the plug of the drug container is stuck with one edge of the needle and thereafter the closing film of the flexible bag is stuck with the other end of the needle. The mixing procedure is sure and simple, and can be carried out in a short period of time.

Abstract: A connector has one end for receiving a standard auxiliary line adaptor hub and an opposite end receivable over an intravenous line port in a male-female interference fit. A needle is provided in the interior of the connector and punctures a sealing membrane provided over the line port. After the needle has been properly positioned in the line port, an external ring is slid axially over the male-female connection to tighten the interference fit.For a heparin flush, a cylinder has two chambers, one for holding heparin and another for holding saline. The two chambers are separated by a membrane. A rubber stopper is provided at one end of the cylinder and is provided with a screw connector for receiving a plunger. The opposite end is provided with a needle having inner and outer points, the needle being recessed into an end portion of the cylinder.The outer end of the needle is provided with a sheath which is removed prior to sliding an intravenous line port into the cylinder.

Abstract: A coupling device for establishing fluid communication between a first container and a second container is provided. The device includes a first sleeve member including at a first end thereof, a member for connecting and securing the first sleeve member to a first container. A second sleeve member is provided and is so constructed and arranged that it receives a portion of the first sleeve, and is operatively adapted for axial sliding engagement thereon, including at one axial end thereof a member for releasably engaging and securing the second sleeve member to a second container. Piercing members located within an area defined by the first and second sleeves are provided for providing fluid flow from the first container to the second container. The coupling device includes a resilient seal for sealing an end of the second sleeve member, located in said second sleeve member at said end adapted to be connected to said second container.

Abstract: A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When the piston is coupled with a plunger, and an adapter cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston has an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded.

Abstract: A disposable blood sampling device wherein inner and outer spaced apart pad members, separated by a compressible pad-bridging enclosure respectively carry an axially extending evacuated collecting container closed by a penetrable end cap and an axially aligned, double-ended cannula. In normal position the cannula is maintained in withdrawn position within the enclosure. The cannula is prevented from penetrating the cap of the collecting tube when the outer member is depressed toward the inner member until after penetration of the epidermis has occurred.

Abstract: A container and needle assembly includes a container body portion having a proximal end, a distal end and a side wall therebetween defining a chamber for retaining fluid and a tip portion extending from the distal end of the body portion having a passageway therethrough. A projection extends outwardly from the tip portion. A pierceable barrier is provided for preventing fluid communication between the chamber and the passageway. A hub having a forward end, a rearward end and a conduit therethrough is movably positioned within the passageway. A first cannula extends outwardly from the forward end of the hub and a second cannula extends outwardly from the rearward end of the hub. A needle shield movably engaging the tip, covers the first cannula. This needle shield has an outer extension portion extending over a portion of the tip which is capable of contacting the projection for limiting the motion of the needle shield toward the proximal end of the body portion.

Abstract: The invention is an integral container system designed for separately storing a liquid, such as a diluent, and a second substance, such as a medicament, and subsequently adding the second substance to the liquid in a simple and sterile operation. In one embodiment, a flexible I.V. bag is provided with a second substance dispensing cup containing a powdered medicament, which cup fits slidably in a sleeve passing through the walls of the bag. Fitted in the open end of the cup is a pierceable plunger. A hollow needle is held in position to pierce the plunger when the cup is pushed toward the needle. The needle is slidably held so that when it is pushed by the plunger, it will also pierce a diaphragm fitting over the sleeve. When both the plunger and the diaphragm are pierced, fluid access between the cup and the bag is had through the hollow needle. Diluent can then be injected into the cup to dissolve or slurry the powdered medicament.

Abstract: Various embodiments of an improved reconstitution device 30, 168, 170, 186, 242, 256, 274 are disclosed, directed to the proper mixing of two substances, and are particularly directed to the medical field for the reconstitution of a drug 36 which may be stored in a drug vial 32 with a diluent 60 stored in a flexible medical solution container 34 and used for the intravenous delivery of a medicament. In one embodiment the reconstitution device 30 includes an improved vial adapter 76 and bag adapter 78 which permit the permanent coupling of the vial 32 and liquid container 34. The bag adapter 78 may be rotatable relative to the vial adapter 76 to operate a valve including a stem channel 108 and a base post 148 on the vial adapter 76, a base segment channel 136 and a cut out portion 146 of a rim 140 on the bag adapter 78, and a sealing segment 80 disposed between the vial and bag adapter 76, 78.

Abstract: A refill unit for a negative pressure type implanted infusion device includes a hollow cylindrical housing member which is adapted to receive at one end a bottle of vacuum conditioned medication. As the bottle is inserted first and second needles or tubes penetrate the closure member of the bottle, the shorter one of these needles being positioned to receive medication inside the bottle and the longer one extends into the ullage space of the bottle when it is inserted and held vertically. The shorter needle communicates with a refill needle, which extends downwardly from the other end of the cylindrical member, through a membrane type filter which is hydrophilic to the medication and has a micron rating such that the filter once it is wetted can pass air bubbles but only at a differential pressure substantially greater than the negative pressure differential of the implanted device.

Abstract: An improved additive transfer device for storing and subsequently transferring a fluid material from an additive container to a rigid or semirigid solution container having an exposed closure. The improved additive transfer device is mounted on the additive container and includes a closure assembly fabricated from three components; a pierceable stopper, a slidable piercing pin and a hood member. The closure assembly is adapted to be positioned on the solution container. The two ended slidable piercing pin is disposed in a central opening in the pierceable stopper so that one end will pierce a diaphragm contained in the pierceable stopper. Resistance elements are provided between the slidable piercing pin and the central opening in the pierceable stopper to hold the slidable piercing pin away from the diaphragm in the pierceable stopper in one position and allow the slidable piercing pin to pierce the diaphragm and retain it within the central opening in a second position.

Abstract: A reconstitution device for constituting a drug in a standard drug vial with a liquid in a second container such as a parenteral solution container is provided. The reconstitution device 10 includes a housing 52 and a hollow, double-pointed needle 54 mounted within the housing. The housing includes a sheath 70 having a substantially circular base 72 and a skirt 74 depending from the base. The skirt 72 includes a free end 76, a substantially cylindrical inner surface 78 and an outer surface 80. A plurality of inwardly projecting bumps 82 are intermittently spaced about the inner surface 78. The bumps are disposed a substantially equal distance from the base 72, the distance being substantially equal to the width of the malleable band.

Abstract: A device for transferring a liquid from a bottle at substantially atmospheric pressure to a bottle at a low pressure comprises a hollow needle of steel or the like mounted in a grip or handle member having a configuration to facilitate the pushing of the needle through a bottle stopper at either end of the device. The needle is sharply pointed at both ends and the handle consists of a strip of steel or other suitable metal bent at its ends to provide stops having holes to accommodate the needle which extends beyond the stop at each end. The strip is bent or bowed toward the center portion of the needle and is soldered or otherwise secured to the needle. The sloping portions of the strip provide thumb rests for pushing the needle in either direction.

Abstract: A hypodermic syringe capable of pre-filling aseptically from either end. Both ends of the rimmed syringe barrel are sealed and capped with standard vaccine or syringe vial closures and crimped aluminum seals. Both ends of the pre-filled and sealed syringe maintain assured sterility integrity by guaranteed microbe-proof barriers during the entire shelf life of package or container. The syringe is prepared for use by simply removing protective caps or seals. The needle assembly is packaged separately and placed in position on syringe by a simple action.

Abstract: A liquid transfer device is disclosed which comprises a body having a wall defining a cavity within the body. Two hollow conduits extend from the cavity through the wall and project outwardly from the body. Two resilient tubes extend through the body and are attached in fluid flow communication to each of the hollow conduits. A roller clamp is provided within the cavity of the body for selectively applying or releasing compressive force on the resilient tubes to selectively permit or prevent fluid flow through such resilient tubes. A double lumen needle is attached to the body such that the needle engages the two hollow conduits projecting outwardly from the body. Each lumen within the needle is in fluid flow communication with one of the hollow conduits and thereby one of the resilient tubes. One of the resilient tubes is connected at its distal end to a liquid source to be transferred. The remaining resilient tube is connected at its distal end to a vacuum source.

Abstract: A sterile coupling enabling the selective establishment of a sterile pathway between two separate receptacles. A preferably injection molded plastic junction is made about at least the end portions of access means to each of the separate receptacles. The junction provides a sterile coupling so as to selectively bring the access means into pathway communication and thereby establish a sterile pathway between the receptacles through the access means. Also disclosed are methods for manufacturing a sterile coupling and methods for establishing a sterile pathway between the receptacles, as well as a method for low pressure injection molding.

Abstract: A sterile coupling enabling the selective establishment of a sterile pathway between two separate receptacles. A preferably injection molded plastic junction is made about at least the end portions of access means to each of the separate receptacles. The junction provides a sterile coupling so as to selectively bring the access means into pathway communication and thereby establish a sterile pathway between the receptacles through the access means. Also disclosed are methods for manufacturing a sterile coupling and methods for establishing a sterile pathway between the receptacles, as well as a method for low pressure injection molding.

Abstract: A sterile container for a medicinal material which is to be intermixed in an I.V. solution wherein the container serves as a mixing device as well as a portion of an I.V. administration apparatus. The device of this invention includes a container which is closed at opposing ends by pierceable diaphragm portions. Extending from one end is a piercing pin having a diaphragm piercing portion which can pierce the diaphragm when it is moved inwardly into the container and also provide a fluid passageway for the container contents. At the opposing end a diaphragm is housed in a closure with a flexible end wall and a tubular guide section for the piercing pin of an I.V. administration set. The container therefore serves a dual function of holding a fluid material such as a powder in a sterile condition yet serving as a component of an I.V. set to thereby afford a quick and simple procedure for mixing additive components into an I.V. administration set.

Abstract: A sterile container for a medicinal material which is to be intermixed in an I.V. solution wherein the container serves as a mixing device as well as a portion of an I.V. administration apparatus. The device of this invention includes a container which is closed at opposing ends by pierceable diaphragm portions. Extending from one end is a piercing pin having a diaphragm piercing portion which can pierce the diaphragm when it is moved inwardly into the container and also provide a fluid passageway for the container contents. At the opposing end a diaphragm is housed in a closure with a tubular guide section for the piercing pin of an I.V. administration set. The container therefore serves a dual function of holding a fluid material such as a powder in a sterile condition yet serving as a component of an I.V. set to thereby afford a quick and simple procedure for mixing additive components into an I.V. administration set.