Abstract: An implant can include a frame and a mesh component coupled to the frame. The mesh component can define a first porosity, and the frame can define a frame porosity. The combined porosity of the mesh component and the frame can restrict blood flow into the implant.

Abstract: Snare device with anti-skewing. In one embodiment, the snare device includes a core-wire. The core-wire is made of a superelastic material and includes a proximal portion of greater cross-sectional area and a distal portion of lesser cross-sectional area. The distal portion includes a looped shape in a relaxed state. A flexible coil is mounted around the core-wire and is straight in a compressed state. The distal ends of the core-wire and the coil are coupled together. The proximal end of the core-wire is coupled to a handle of an actuator, and the proximal end of the coil is coupled to a slide of an actuator, the slide being slidably mounted on the handle. The tensile strength of the coil multiplied by the cross-sectional area of the coil is greater than the upper plateau stress of the core-wire distal portion multiplied by the cross-sectional area of the core-wire distal portion.

Abstract: A device for extracting an endovascular stent graft from a vessel including a cylindrical body and an opening formed in the cylindrical body. The cylindrical body has a first open end, a second open end, and a sidewall surrounding a hollow bore of the cylindrical body. The opening is formed in the sidewall between the first open end and the second open end forming a first ring portion at the first open end and a second ring portion at the second open end. Additionally, a thickness of the sidewall at the first open end tapers toward the opening and wherein a thickness of the sidewall at the second open end tapers toward the opening such that the hollow bore is narrower at each end than at the opening.

Abstract: A system for retrieving material or objects from a biological vessel is provided. the system includes an elongated braid structure configured for transitioning between collapsed and expanded states, the elongated braid structure surrounding a lumen having a distal opening when in the expanded state. The system further includes a closure wire positioned along a length of the elongated braid structure, the closure wire being actuatable to pull inward a distal portion of the elongated braid structure and thereby at least partially close the distal opening.

Abstract: Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot. The devices can include an elongate pusher member and a self-expandable capturing member coupled to a distal end of the elongate pusher member. The capturing member can comprise a generally cylindrical body having an cell structure that is configured to compress the clot against an inner wall of the neurovasculature and capture the clot at least partially on a surface of the generally cylindrical body upon deployment of the capturing member from the microcatheter, thereby restoring blood flow to the neurovasculature downstream of the clot.

Abstract: Vascular filters and deflectors and methods for filtering bodily fluids. A blood filtering assembly can capture embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature. A blood deflecting assembly can deflect embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature.

Abstract: An occlusion device formed of a microcoil having a three-dimensional relaxed state employing open looped portions interposed between closed loop portions. Planes defined by sequentially formed open looped and closed loop portions are neither coincident nor parallel to one another.

Abstract: An implant having an elongated portion and an expandable braided sack portion can be delivered through a catheter and implanted in an aneurysm such that elongated portion loops within the braided sack, the braided sack contacts a majority or all of the aneurysm wall, and the braided sack at least partially occludes the aneurysm neck.

Abstract: The present disclosure is directed to an Inferior Vena Cava (IVC) filter apparatus and related methods. The IVC filter apparatus comprises a body having a proximal hook thereon. A plurality of filter legs extends away from the proximal hook. A distal hook is position interior to at least a portion of the plurality of legs.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a collapsed configuration and an expanded configuration, wherein the expandable framework includes a plurality of strut members circumferentially spaced around a longitudinal axis of the expandable framework, wherein one or more of the plurality of strut members includes a first twisted portion and a face portion. The occlusive implant also includes a plurality of fixation members disposed along the face portion of one or more of the plurality of strut members.

Abstract: The invention relates to a passive transponder having at least one coil, the transponder having an electrically conductive shield which covers the windings of the coil from both sides. A central region of the coil around which the windings are wound is not covered by the shield. In the surfaces, in which the shield covers the windings, the shield has at least one discontinuity by which a current flow in the shield can be prevented.

Abstract: Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage.

Abstract: A tissue specimen retrieval device includes a first shaft having a pair of slots defined in a distal end thereof and a pair of windows defined proximally of the pair of respective slots. A second shaft is included having a bag brim attached thereto, the second shaft telescopically movable within the first shaft between a retracted position, wherein the bag brim is disposed within the first shaft and a partially deployed position wherein the bag brim partially deploys from the first shaft forming an enclosure for supporting the tissue bag thereon. A pair of hook members is included each having an arm, a first end engaged to the bag brim and a free end including a hook at a distal end thereof. Upon deployment, the hook of each hook member engages a respective window allowing each respective arm to pivot outwardly within respective slots to fully deploy the bag brim.

Abstract: A medical device, configured to perform an endovascular therapy, e.g., thrombectomy, can comprise an elongate manipulation member and an intervention member. The intervention member can comprise a proximal end portion and a mesh. The proximal end portion can be coupled with the distal end portion of the elongate manipulation member. The mesh can have a plurality of cells and, be compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter, and be self-expandable from the collapsed configuration to an expanded configuration. At least a portion of the mesh, from a first location to a second location along the mesh, can be configured such that an amount of cell deformation in response to longitudinally directed tensile forces decreases by less than 5% or increases in a distal direction along the portion of the mesh.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, is directed toward an occlusive device that includes a first mesh having an expanded state in which it curves about a first axis to form a first band, and a second mesh having an expanded state in which it curves about a second axis different than the first axis to form a second band. The second band may be positioned radially inward of the first band such that the device includes first and second overlap regions in which the first band overlaps the second band.

Abstract: An incising implant for creating incisions in the prostatic urethra of a subject, the implant including at least two closed-shaped wires, each of the wires having a proximal section, a distal section and two longitudinal sections extending between the proximal section and the distal section, each of the closed-shaped wires being elastic thereby being compressible into a compressed configuration, each of the longitudinal sections of each of the wires being adjoined with another longitudinal section of another one of the wires.

Abstract: A prosthetic heart valve delivery catheter includes an embolic filter to provide integrated embolic protection to inhibit the release of emboli into the aorta, the aortic arch or branch vessels, and other vasculature during transvascular heart valve replacement procedures. The embolic filter will usually be fixedly or movably attached to a shaft of the delivery catheter proximal of the prosthetic heart valve.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include first and second permeable shells. The first permeable shell having a proximal end with a concave or recessed section and a second permeable shell having a convex section that mates with the concave or recessed section. The implant also includes a flexible, articulating joint between the first and second permeable shells.

Abstract: A blood clot removal device for removing blood clots from the vascular system of a patient is implantable in the patient's body. The blood clot removal device comprises a blood flow passageway to be connected to the patient's vascular system to allow circulation of the patient's blood through the blood flow passageway, a filter provided in the blood flow passageway for collecting blood clots occurring in the blood flowing through the blood flow passageway, and a cleaning device for moving blood clots collected by the filter out of the blood flow passageway. By means of such blood clot removal device, the risk of blood clots reaching sensitive areas of the patient's body, such as the brain, is reduced.

Abstract: A vascular embolization device includes a coil with a primary shape and an stretch resistant wire provided inside the coil, in which the stretch resistant wire is a multilayer strand including at least one core layer and at least one outer layer including one or more resin compositions and a biochemical active material, and the core layer is composed of a material with a tensile break strength higher than that of the outer layer. The vascular embolization device has the function of administering a biochemical active material and also has good flexibility.

Abstract: A clot encasement and removal device for removing a vascular obstruction is disclosed. The encasement device comprises proximal and distal capture members and a central stabilizer. The central stabilizer provides several points of contact for interacting with and manipulating an intravascular obstruction. The central stabilizer may be coupled to the distal capture member, allowing the central stabilizer and distal capture member to be manipulated in unison. The central stabilizer may reside on a distinct delivery wire, enabling independent control of proximal and distal capture members and the central stabilizer. The proximal capture member may comprise a furrowed delivery wire to enable retraction of at least a portion of the central stabilizer within the proximal capture member.

Abstract: A method of making a vascular occlusion device may include cutting a tubular member to form an expandable frame including a first hub integrally formed with the expandable frame adjacent a first end of the expandable frame, and a plurality of longitudinally-oriented struts extending in a direction opposite the first end; heat-setting the expandable frame to define an expanded configuration of the expandable frame; sliding a constrainment member over the plurality of longitudinally-oriented struts, the constrainment member being formed using additive manufacturing technology; fixedly securing the constrainment member to the plurality of longitudinally-oriented struts to define a second hub of the expandable frame; and cutting the plurality of longitudinally-oriented struts adjacent the constrainment member and opposite the first end relative to the constrainment member.

Abstract: A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.

Abstract: A method for treating at least one of an ophthalmic artery or an ostium between the ophthalmic artery and an internal carotid artery of a subject may include delivering a microcatheter to a location within vasculature of the subject. The method may further include delivering a filter to a location within at least one of the ophthalmic artery or the ostium and transitioning the filter between a first delivery configuration and a second deployed configuration. Further, the method may include deploying a stent to a location within the internal carotid artery.

Abstract: An example system can include a tubular braid, a catheter, and an embolic coil. The tubular braid can have an open end, a pinched end, and a predetermined shape. In the predetermined shape, the tubular braid can have two inversions and a middle segment extending between the two inversions that forms a sack. The tubular braid can be implanted in an implanted shape based on the predetermined shape. A distal end of the catheter can be inserted into the sack when the tubular braid is implanted. The embolic coil can be delivered through the catheter into the sack. The opening to the sack can correspond to a constricted columnar segment of the middle segment when the braid is in the predetermined shape.

Abstract: A system to detect a medical device within a biological subject, the system comprising: an imaging system operable to generate image data derived from the biological subject and image data derived from the medical device; and a processor operable to detect the medical device and evaluate the image data derived from the medical device to identify the nature of the medical device. Further, a system to match a signature from a detected medical device within a biological subject with signature information held in a databank for a plurality of medical devices, the databank also holding specification information corresponding to the plurality of medical devices, the system being operable to match a signature relating to a detected medical device with signature information held in the databank and to provide some or all of the specification information for the matched signature to identify the nature of the medical device.

Abstract: Implants can be used as flow diverters for treating aneurysms. Implants can include a stabilizing frame for anchoring the implant and an occluding element for diverting blood flow from the aneurysm neck. The stabilizing frame can have two parts, the first part sized to anchor within the sac of the aneurysm and the exterior part sized to anchor against a region of the blood vessel wall adjacent the aneurysm neck. The occluding element can be attached to the interior frame and positioned to occlude the aneurysm neck. The implant can have a central node that can be positioned near the center of the aneurysm neck at which the interior frame is attached to the exterior frame and from which the interior frame and the exterior frame extend.

Abstract: A clot retrieval device is provided. The clot retrieval device includes a capturing basket having an opening at a proximal end where the capturing basket is deployable downstream from a clot in a blood vessel. The capturing basket is configured to surround a portion of the clot and the opening in the proximal end of the capturing basket is configured to reduce in size such that the capturing basket conforms around the portion of the clot and be retrieved after the capturing basket conforms around the portion of the clot.

Abstract: A lung volume reduction elastic implant (500) and a lung volume reduction instrument are provided. The lung volume reduction elastic implant (500) has an elastic deformation part (51), and a flexible guide (53, 53a) connected to the distal end of the elastic deformation part (51). The flexible guide (53, 53a) is provided with a first flexible part (531). The first flexible part (531) has an insert part (5312) and a distal part (5311). The insert part (5312) is connected to the distal end of the elastic deformation part (51). The distal end of the distal part (5311) of the first flexible part (531) is the distal end of the lung volume reduction elastic implant (500). The first flexible part (531) is internally provided with a radiograph component (56).

Abstract: An endovascular treatment system includes a delivery sleeve that is insertable into an intravascular catheter. A therapeutic device is housed coaxially within the delivery sleeve and both are advanced within the catheter in combination. An advancement mechanism is connected to the therapeutic device to advance the therapeutic device out of the delivery sleeve and into a patient. The delivery sleeve includes a stop positioned on the proximal end. The stop contacts the proximal end of the catheter, limiting the distance the delivery sleeve is inserted into a catheter.

Abstract: In embodiments of an obstruction removal device, system, and/or method, an expandable member is configured to be slidably coupled to a guide wire. The expandable member is configured to surround at least a portion of an obstruction captured by a stentriever as the expandable member transitions from the expanded state to the contracted state, i.e., when the guide wire is removed from a vasculature to remove the stentriever and the obstruction from the vasculature. A first locking member is located at a base of the expandable member. The first locking member is configured to engage a second locking member that is located on the guide wire, the stentriever, or an inner surface of a guide catheter, thereby coupling the expandable member to the guide wire, the stentriever, or the inner surface of the guide catheter when the expandable member is deployed within the vasculature.

Abstract: A clot removal device for removing clot from a body vessel comprising an expandable structure and an elongate member. The elongate member can have a proximal end and a distal end, the elongate member being connected to the expandable structure at its distal end. The expandable structure can have a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration. At least a portion of the expandable structure can be configured to engage clot in the expanded deployed configuration and to pinch clot on movement from the deployed configuration to the clot pinching configuration.

Abstract: A device including a clot engaging device having a collapsed delivery configuration and an expanded deployment configuration. The device can include a plurality of struts defining a plurality of cells; a seam extending along at least a portion of a length of a distal end of the clot engaging device, wherein the seam comprises a pattern configured for gripping a clot and extends between cells of the plurality of cells; and a distal scaffolding region being distally tapered, wherein the distal scaffolding region comprises cells smaller than cells of a remainder of the clot engaging device.

Abstract: Aspects of the present disclosure are directed toward catheter-based apparatuses, such as componentry utilized with or as part of catheters, or as catheters or catheter assemblies. As may be implemented in accordance with one or more embodiments, a method and/or apparatus involves a filter having a frame that forms a perimeter of the filter and separates opposing surfaces thereof. An articulated arm is connected to the frame and configured therewith to, when deployed within a tubular organ, engage with opposing inner sidewall portions of the tubular organ and to utilize the inner sidewall portions to seal filter to the inner sidewall by applying force to the frame.

Abstract: A tissue specimen retrieval device includes an outer shaft including a proximal portion and a distal portion. The distal portion of the outer shaft includes a first jaw defining a first side of a lumen in the distal portion of the outer shaft. A second jaw defines a second side of the lumen in the distal portion of the outer shaft. The first and second jaws are actuatable between a closed configuration and an expanded configuration in which the first and second jaws are spaced relative to each other. A tissue specimen bag is supported by the first jaw and the second jaw. A bag brim of the tissue specimen bag defines a collapsed configuration when positioned in the lumen defined by the first jaw and the second jaw and an open configuration when the first and second jaws are in the expanded configuration.

Abstract: A minimally invasive endovascular device for treating a blocked or obstructed biological lumen, such as a blood vessel fully or partially obstructed by deposits of biological matters in or non-biological matters. Certain embodiments of the present invention comprise two capture members that are configured to be placed on either side of the obstruction and enclose around the obstruction for removal. Embodiments of the present invention also provide methods for implementing an endovascular device according to aspects of the present invention.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework including a height and a plurality of support members defining a proximal end region of the expandable framework and a central hub member attached to the plurality of support members. Additionally, the expandable framework is configured to shift between a first configuration and a second configuration, wherein the height of the expandable framework remains substantially the same in both the first configuration and the second configuration. Further, the central hub member is configured to shift relative to the proximal end region while the expandable framework shifts between the first configuration and the second configuration.

Abstract: The invention relates to an implant for vascular applications that can be transported by means of a catheter and is intended in particular to influence the blood flow in the area of arteriovenous malformations, such as fistulas and aneurysms, to fill the saclike dilation of the malformation, promote thrombus formation and cover the neck of the malformation. The implant according to the invention is provided with an occlusion unit (1, 13) having a three-dimensional shape constructed from several subunits (5a, 14) from a framework of struts (5, 16, 17), with a covering, preferably a membrane (6), being located between struts (5, 16, 17).

Abstract: Methods and apparatus for use in capturing embolic debris during a surgical procedure in a patient are provided. The methods include utilizing an embolic capture device that is configured for delivery into a patient via a transapical delivery approach and via an arterial delivery approach, and determining which of a transapical delivery approach and an arterial delivery approach should be used with the patient. The methods also include inserting the embolic capture device within a delivery system, and deploying the embolic capture device at a desired location within the patient's blood vessel that is downstream from the location of the surgical procedure. The same embolic capture device is configured for use with a transapical delivery approach and an arterial, such as a transfermoral, delivery approach.

Abstract: Provided are medical devices, systems and methods for retrieval and/or extraction of a corpus located in a tubular organ. Systems of this disclosure are configured for carrying out various procedures for removal of occlusive corpus from tubular organs, for example thrombectomy.

Abstract: A catheter system (110) for removal of occlusive material in a body lumen. The catheter system (110) includes a catheter body (10), extending between a distal end (20) and a proximal end (22) and having a proximal portion (29) and a distal portion (28). The catheter body (10) includes a filtration section (30A) having filter media (32) configured to permit blood to pass through the lumen of the catheter body (10) and inhibiting occlusive material from passing out of the catheter body (10). The catheter system (110) also includes a control handle (120) coupled to the proximal portion (29) of the catheter body (10) and a cutter assembly (12) having a drive mechanism (40) operatively coupled to the control handle (120). The cutter assembly (12) includes a drive mechanism (40) and a conveyor (44) coupled to the drive mechanism (40) and rotatable with the drive mechanism (40) to convey occlusive material proximally within the catheter body (10) and through the filtration section (30A).

Abstract: Disclosed are coating compositions, processes, and designs for endowing vascular devices with thromboresistant and endothelializing properties. Also disclosed are designs of vascular devices used as aneurysm treating devices for assisting in the delivery, packing, and maintenance of embolization coils within an aneurysm, particularly a neurovascular aneurysm.

Abstract: The devices and methods described herein relate to improved structures for removing obstructions from body lumens. Such devices have applicability in through-out the body, including clearing of blockages within the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate and/or mobilize the obstruction within the body lumen.

Abstract: An embolus filter introducer system has a symmetric introducer sheath with a filter inside. The introducer sheath can be attached at either end to a deployment actuator. The deployment actuator can thereby be used to push the filter out of the introducer sheath. Since the sheath can be oriented in a selectable direction, so can the filter, allowing the sheath to be introduced via a jugular or femoral approach to the vena cava.

Abstract: A thrombus treatment device includes a support wire, a body frame portion that is disposed about an axis defined by the support wire, one or more tethers that each have a first end and a second end, and a filter element extending from the body frame portion. Each of the one or more tethers is attached at its first end to the body frame portion, and at its second end to a collar that couples the second end of each of the multiple tethers to the support wire. When the collar is positioned substantially within a region interior of the body frame portion, a rotational actuation of the support wire causes a swiveling motion of the one or more tethers.

Abstract: An apparatus for treating an aneurysm in a blood vessel includes an occlusion element including a first tubular mesh having a first end and a second end coupled together at a proximal end of the occlusion element such that an intermediate portion of the first tubular mesh between the first end and the second end includes a substantially 180 degree turn, the intermediate portion of the first tubular mesh extending distally from the proximal end of the occlusion element, wherein the intermediate portion of the first tubular mesh has a collapsed configuration and is configured to expand to an expanded. In some embodiments, the apparatus further includes a second tubular mesh having a first end and a second end coupled to the proximal end of the occlusion element such that an intermediate portion of the second tubular mesh between the first end and the second end includes a substantially 180 degree turn.

Abstract: A mechanical thrombectomy device, and methods of manufacturing and using the mechanical thrombectomy device, are described. The mechanical thrombectomy device includes several clot arrestors independently mounted on a support wire. The clot arrestors have expandable frames that are eccentrically supported on the support wire. The independently and eccentrically mounted clot arrestors are arranged to allow a clot to pass into, and be captured by, one of the expandable frames. Furthermore, the independently and eccentrically mounted clot arrestors deform independently of one another such that retraction of the mechanical thrombectomy device through tortuous vasculature can stretch one clot arrestor without stretching another one of the clot arrestors to allow the clot to be retained by the unstretched clot arrestors. Other embodiments are also described and claimed.

Abstract: Devices for removing clot material from a blood vessel lumen and associated systems and methods are disclosed herein. A clot retrieving device may include, for example, an elongated shaft, a capture structure, a cover, and a connector coupled to the elongated shaft proximal of the capture structure. The connector may include an inner band and an outer band, wherein (a) the inner band at least partially surrounds a portion of the distal zone of the elongated shaft, (b) the outer band at least partially surrounds the inner band, and (c) the first portion of the cover is secured between the inner band and the outer band.

Abstract: Implants comprising electrically-responsive hydrogel are described. Systems to provide electricity to induce response in hydrogel-containing implants are described. Methods for utilizing said system and methods for utilizing said hydrogel-containing implants are described.

Abstract: An apparatus for treating an aneurysm in a blood vessel includes an occlusion element disposed on a wire, the occlusion element including a cover for covering a neck of an aneurysm and an inner anchoring member. The cover is configured to expand from a compressed configuration in a tube to an expanded configuration when advanced out of a distal end of the tube to cover the neck of the aneurysm. The cover includes a sphere of mesh material formed into a hemisphere including two layers of mesh that is formed by folding a top portion of the sphere into a bottom portion of the sphere. The inner anchoring member is coupled to and extends from the second surface of the cover and is configured to contact an interior surface of the aneurysm. The inner anchoring member may be a cylindrical stem extending from a central portion of the cover.