Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for placement in vessels, appendages, and openings in a body including a frame having a proximal end, a distal end, and a longitudinal axis. In certain instances, the frame includes a waist portion angled relative to the longitudinal axis and one or more anchors arranged along the waist portion.

Abstract: In embodiments of an obstruction removal device, system, and/or method, a removal tool and an expandable member are configured to be disposed at a distal end of a delivery tool. The removal tool may include peeler wires and hook wires that are configured to at least partially separate an obstruction from an inner surface of a vasculature. The expandable member is configured to at least partially surround the removal tool and is further configured to grasp at least one portion of the removal tool and the obstruction as the expandable member transitions from an expanded state to a contracted state when the delivery tool is removed from the vasculature to remove the removal tool and the obstruction from the vasculature.

Abstract: A medical device and methods for altering lung volume are disclosed. The medical device includes a coil formed of a biodegradable material including a first bioabsorbable material that is configured to deactivate a portion of a lung as the coil degrades. The method includes positioning a first coil adjacent a first target within a patient and permitting the first coil to degenerate such that a first bioabsorbable material deactivates a first portion of a lung. The first coil is formed of a biodegradable material and includes the first bioabsorbable material.

Abstract: A heart valve sizer and sizer cover are provided for determining the size of a heart valve annulus. The valve sizer can include a handle, a shaft extending distally from the handle, a sizing element coupled to the distal end of the shaft, the sizing element being movable between a first retracted position and a second expanded position, and a sizer cover. The sizer cover can be formed from a continuous sheet of material configured to surround at least a portion of the sizing element of the heart valve sizer so as to guard against entanglement of the sizing element with structures of a human heart.

Abstract: In some aspects, the present disclosure pertains to self-expanding emboli-capturing centering devices for centering a medical instrument in a conduit within a patient. The centering devices comprise (a) an elongate shaft, (b) a self-expanding centering member having an open distal end and an inner surface forming a central lumen with a flared distal portion, the centering member being configured such that a fluid flowing in a distal-to-proximal direction that is received by the open distal end flows proximally along the flared distal portion of the central lumen before exiting the central lumen through one or more openings in a proximal portion of the centering member, and (c) a filter material configured to filter the fluid received by the open distal end of the centering member. Other aspects of the present disclosure pertain to systems and methods employing such centering devices.

Abstract: An embolic protection device includes an expandable and contractible filter that can be supported by one or more struts. The struts can be connected to the filter or interwoven into the filter, so as to assist in the expansion and contraction of the filter. In one embodiment, the proximal ends of the struts connect to a joint that is fixed in position relative to a delivery wire, while the distal end of the filter connect to a joint that slides relative to the delivery wire.

Abstract: A filter (10) includes a proximal end (1), a distal end (2) and a main filter body connected between the proximal end (1) and the distal end (2). The main filter body has a first filter unit (3) and a second filter unit (4), both being conical mesh structures, as well as multiple intermediate connection posts (5) connecting the first filter unit and the second filter unit. The intermediate connection posts (5) have provided thereon support posts (6). A support post (6) includes a transition segment (61) extending from an intermediate connection post (5) to a blood vessel wall, and a support segment bent and extending from the transition segment (61), and at least partially abutting the blood vessel wall. The support segment has a main body (62) bent and extending from the end of the transition segment (61) and a flexible segment (63) bent and extending from the main body (62).

Abstract: A percutaneous transluminal angioplasty device, comprising an elongated catheter, an interventional device operably coupled to the proximal end of the catheter, a filter operably coupled to the distal end of the catheter, the filter movable between a collapsed and deployed position, and an actuator wire for deploying the collapsing the filter. At least a portion of the actuator wire extends within the catheter. The filter comprises a filter chassis comprising a movable collar a fixed collar and a tubular braided scaffolding coupled between the movable collar and the fixed collar. The filter chassis also comprises a filter membrane coupled to the tubular braided scaffolding.

Abstract: A platform of devices for removing obstructions and other objects within a blood vessel or other interior lumen of an animal is provided. The system may be deployed in the lumen from a catheter(s) and the system may include a cage comprising a suction catheter comprising one or more suction openings located in the cage interior in order to draw the clot or other object into the cage interior.

Abstract: Vascular filters and deflectors and methods for filtering bodily fluids. A blood filtering assembly can capture embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature. A blood deflecting assembly can deflect embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature.

Abstract: A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member.

Abstract: A clot retrieval device for removing occlusive clot from a blood vessel. The device comprises an inner elongate body having a collapsed delivery configuration and an expanded deployed configuration. An outer elongate body is at least partially overlying the inner elongate body. The outer elongate body is expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space. The outer elongate body has a plurality of clot receiving openings and a plurality of clot engaging regions. The clot engaging regions are adapted, on engagement with clot, to urge clot towards the clot receiving openings and into the reception space between the outer elongate body and the inner elongate body, wherein the radial force profile of the device varies along the length of the device.

Abstract: A catheter according to an embodiment of the present disclosure includes a mesh member, a first hollow shaft, a front end tip, a guiding film, a second hollow shaft, and a core wire. The mesh member has a tubular shape and is radially expandable and contractable. The guiding film is disposed on the mesh member and has a front end located between a base end of the front end tip and a front end of the first hollow shaft. A thickness of the front end of the guiding film is larger than a thickness of a portion where a thickness of the guiding film is the smallest.

Abstract: Single filter and multi-filter endolumenal methods and systems for filtering fluids within the body. In some embodiments a blood filtering system captures and removes particulates dislodged or generated during a surgical procedure and circulating in a patient's vasculature. In some embodiments a filter system protects the cerebral vasculature during a cardiac valve repair or replacement procedure.

Abstract: A blood filter delivery system for delivering a filter into a vein from either a femoral or jugular access. The preferred system includes an introducer and a push-rod with a spline member disposed along the push-rod and a pusher member disposed on a distal end. The spline member has a main body, first and second boss portions spaced apart along the longitudinal axis to provide a gap for retaining anchor members of the filter during delivery via the introducer. In an alternative embodiment, a preferred filter includes first and second filter structures diverging in opposite directions. A link is connected to portions of each of the first and second filter structures so that each filter structure can be independently collapsed into a generally cylindrical shape.

Abstract: Systems, devices, and methods for removing and/or treating obstructions in the vascular channels, such as blood clots, are provided. The systems may include a capture sock device including a shaft defining a lumen; and a mouth coupled to the shaft. The mouth includes a distal end portion defining a distal opening and is sized and configured to move between a collapsed configuration and an expanded configuration within a body channel. The mouth is formed of a mesh having porosity large enough to allow blood flow to pass through it but small enough to prevent an obstruction or a fragment of the obstruction from escaping from the mouth back into the body channel. In some embodiments, the mesh is folded to create at least two mesh layers at least at the distal opening to create a smooth atraumatic edge. In some embodiments, the system further includes a trap and/or retriever assembly.

Abstract: An inferior vena cava filter (340) for use in the inferior vena cava (4) to capture thrombus (8) passing through the inferior vena cava (4) towards the heart and lungs to prevent pulmonary embolism comprises a proximal support hoop (302), a distal support hoop (312) and a plurality of support struts (303) extending between the proximal support hoop (302) and the distal support hoop (312). The filter (340) also comprises a plurality of capture arms (121) which are movable from a capturing configuration to an open configuration. The capture arms (121) are biased towards the open configuration. A biodegradable suture holds the capture arms (121) in the capturing configuration.

Abstract: A thrombectomy catheter with a catheter or delivery sheath having a dual lumen extending therethrough, the catheter having a proximal segment and a distal segment and a linear section coupled therebetween, the distal segment configured as a loop, a port or aperture formed therein said dual lumen of said catheter, the port positioned proximate the distal segment, and a guidewire configured to longitudinally traverse therethrough one of the dual lumen of the catheter, said guidewire having a first end affixed to a mesh strainer, the mesh strainer configured to longitudinally traverse therethrough the other of the dual lumen of the catheter and exit therethrough said port and follow said loop to form retractable mesh strainer.

Abstract: A specimen retrieval device includes a tubular body, an inner shaft slidably positioned within a longitudinal bore of the tubular body, and a specimen bag supported on the distal portion of the inner shaft. In embodiments, the tubular body tubular body is formed of a lubricious material. The specimen bag is formed from a pattern and welded by a radiofrequency welder. The specimen bag includes a tail section through which the inner shaft passes, and the tail section may be attached to a handle at a proximal portion of the inner shaft.

Abstract: A collapsible medical device and associated methods of occluding an abnormal opening in, for example, a body organ, wherein the medical device is shaped from plural layers of a heat-treatable metal fabric. Each of the fabric layers is formed from a plurality of metal strands and the assembly is heat-treated within a mold in order to substantially set a desired shape of the device. By incorporating plural layers in the thus-formed medical device, the ability of the device to rapidly occlude an abnormal opening in a body organ is significantly improved.

Abstract: A system and method used to deliver an aortic valve therapeutic device to an aortic valve site includes a cable percutaneously introduced a cable into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transeptal puncture, and to a femoral artery. The therapeutic device is passed over an end of the cable at the venous side and is secured to the cable. The therapeutic device is pushed in a distal direction while the second end of the cable is pulled in the proximal direction to advance the therapeutic device to the mitral valve site. A left ventricle redirector aids in orienting the therapeutic device and preventing migration of the cable towards delicate mitral valve structures and chordae tendoneae during advancement of the therapeutic device.

Abstract: According to an aspect of some embodiments of the present invention there is provided a device for removal of obstructive material from a vessel comprising: an expandable structure sized for insertion into the vessel; and one or more portion protruding radially from a central longitudinal axis of the expandable structure such that a space between the protrusion and a closest portion of the expandable structure to the portion includes a radial component; wherein the space is sized and shaped to be suitable to accept obstructive material.

Abstract: An example medical device for occluding the left atrial appendage is disclosed. The example medical device for occluding the left atrial appendage includes an expandable member having a first end region, a second end region and an inflation cavity. The example medical device includes at least one fixation member having a first end and a second end coupled to the expandable member. The at least one fixation member is configured to move from a delivery configuration to a deployed configuration in response to an expansion of the expandable member. Additionally, the example medical device includes a valve member extending at least partially into the inflation cavity and the expandable member is configured to expand and seal the opening of the left atrial appendage.

Abstract: The present invention provides devices for removing an embolus or thrombus. The device includes an elongate member configured for insertion into the vasculature, an expandable member that extends from the distal end of the elongate member, and a flow restrictor associated with a proximal portion of the expandable member. The expandable member is configured to transition from a compacted state to an expanded state, in which the expandable portion engages with the embolus. The flow restrictor is configured to restrict blood flow and generate a low pressure zone at a location in the vasculature that is distal to the flow restrictor.

Abstract: An elongate embolectomy device having a radially constrained configuration and a radially expanded configuration, the embolectomy device being formed out of a plurality of elongate clot engaging structures, each clot engaging structure comprising a plurality of interconnected struts forming an open cell pattern, wherein, when the embolectomy device is in the radially expanded configuration, the clot engaging structures each have a semi-tubular arcuate profile, including a convex face and an concave face facing opposite the convex face, extending along a length of the embolectomy device, the clot engaging structures being longitudinally disposed relative to each other such that the concave faces are facing radially outward, and the convex surfaces are facing radially inward, respectively, relative to a longitudinal axis of the embolectomy device.

Abstract: A vascular plug comprises a superstructure expandable from a collapsed percutaneous insertion configuration to an expanded deployment or use configuration. The superstructure is comprised of both primary and secondary three-dimensional shapes allowing for the occlusion of a wide range of vessel sizes from small to large through a disproportionately small delivery catheter. The plug includes a shape memory element for the generation of radial force and the creation of the larger secondary three-dimensional twisting or helical superstructure as is needed for target vessel occlusion.

Abstract: A system and method for delivering an embolic device are disclosed. In one embodiment, the system and method may be directed to a combination of a catheter, coupler, and embolic device. The coupler is disposed inside of the catheter. The embolic device is coupled with a retaining mechanism at the proximal end. Until the embolic device is delivered to a certain location within an artery, the embolic device is engaged with the catheter by engaging the coupler with the retaining mechanism. The embolic device is further secured to the delivery catheter by securing the coupler with a securing mechanism formed on the catheter. When the delivery catheter reaches the desired location in the artery, the embolic device is released from the delivery catheter by simply pulling the coupler proximally such that the loop portion of the coupler first becomes disengaged from the locking window and then from the retaining mechanism.

Abstract: An embolization scaffold device. The scaffold has a base having a central longitudinal axis extending therethrough and a plurality of expandable struts extending from the base. Each of the struts has a proximal portion extending from the base and substantially aligned with the central longitudinal axis, an intermediate arcuate portion radially extending away from the central longitudinal axis, and a distal portion curving back towards the central longitudinal axis.

Abstract: An irising drainage device is disclosed, including an irising collection funnel having a plurality of overlapping petals extending from an annulus defining a central aperture and a conduit extending from the annulus away from the irising collection funnel. The conduit includes a lumen in fluid communication with the central aperture. An irising rectal catheter is disclosed, including an irising collection funnel having a plurality of overlapping elastically deformable petals extending from an annulus defining a central aperture and an elastomeric tube extending from the central aperture away from the irising collection funnel. The elastomeric tube includes a lumen in fluid communication with the central aperture. The irising collection funnel is configured to elastically narrow in response to a radially inward pressure and expand with reduction of the radially inward pressure.

Abstract: A medical device to be inserted into a blood vessel for effectively removing an object flowing in a biological lumen while reducing the burden on the living body includes an elongated shaft portion, and an expansion portion which is an elastically deformable cylindrical body having a plurality of gaps and in which a proximal portion or a distal portion of the cylindrical body is interlocked with the shaft portion. The expansion portion has a ring-shaped or annular bent portion which protrudes toward a proximal side position radially outside the expansion portion in a bent state of being bent along an axial direction, and an axial length of a second portion from the bent portion to a proximal end of the expansion portion is shorter than an axial length of a first portion from the bent portion to the distal end of the expansion portion.

Abstract: The present invention relates to an endoluminal device for implantation in a body lumen, such as a pancreatic duct. The device is provided with a distal end region having greater flexibility than that of a medial region of the device.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a collapsed configuration and an expanded configuration, an occlusive member disposed along at least a portion of the expandable framework and a sealing member disposed along the occlusive member, wherein the occlusive member includes at least a first cellular tissue growth pathway.

Abstract: A catheter including a mesh member having a tubular shape and being radially expandable and contractable, a first hollow shaft connected to a proximal end of the mesh member, a distal end tip, and a core wire. The first hollow shaft includes a distal end side shaft having a distal end connected to the proximal end of the mesh member and a proximal end side shaft having a distal end connected to a proximal end of the distal end side shaft. An opening is provided at the proximal end of the distal end side shaft in a connection portion between the distal end side shaft and the proximal end side shaft. A sealing member covering an outer periphery of the core wire and allowing the core wire to be slidable thereinside is arranged at the distal end of the proximal end side shaft in the connection portion.

Abstract: A bristle device (8) for delivery into a body lumen comprises a longitudinally extending stem and a plurality of bristles extending generally outwardly from the stem for anchoring the device in a body lumen. There may beat least two bristle segments (96) and there are flexible sections (95) between the segments (96). The flexible sections (95) articulate to enable the device to pass through a catheter placed in a tortuous anatomy or to be deployed in a curved vessel, or across a bifurcation. In some cases at least some of the bristle segments (96) are spaced-apart to accommodate bending of the bristles.

Abstract: Disclosed is a guidewire stop configured to lock a medical device onto a guidewire. The guidewire stop comprises a locking element, an actuator coupled to the locking element and a locking tube, wherein at least a section of the guidewire and at least part of the locking element or actuator pass through the locking tube. Further disclosed is that the locking tube comprises an unlocking element configured to unlock the medical device from the guidewire. The disclosed guidewire stop has at least the following three configurations: —an initial unlocked configuration in which the guidewire stop and the medical device are movable relative to the guidewire; —a first locked configuration in which the guidewire stop and the medical device are not movable relative to the guidewire; and—a first unlocked configuration in which the guidewire stop and the medical device are movable relative to the guidewire.

Abstract: Methods, apparatuses and systems are described for expandable stent delivery apparatus to cover an access site. The method may include delivering the stent through an access site and deploying a distal portion of the stent from within an outer sheath. In some cases, the method may further include pushing a proximal portion of the stent from the outer sheath such that upon fully exiting the outer sheath, the proximal portion extends proximally to at least partially cover the access site with the stent. The system for delivering the stent into the body lumen may include a stent, a stent delivery apparatus, and an outer sheath. The system may further include an internal pusher configured to push a proximal portion of the stent from the outer sheath and axially compress the stent such that upon fully exiting the outer sheath, the proximal portion extends proximally to cover the access site.

Abstract: A method is disclosed for collecting substances inside a living body lumen using a medical device having an elongated shaft, a filter portion, and a support portion. The method includes inserting the medical device into the living body lumen; inserting an atherectomy device through the elongated shaft of the medical device; scraping a substance with the atherectomy device; collecting the substance using the filter portion of the medical device; and aspirating the substance by an aspiration catheter while the aspiration catheter is moved forward and rearward relative to the filter portion inside the filter portion.

Abstract: A transorally implantable intragastric helical prosthesis for treating obesity. The helical prosthesis has a primary lumen having a balloon element therein, and a secondary lumen having a spring wire element therein. The prosthesis also includes an end fitting. When deployed into the stomach of a patient, the prosthesis spontaneously reverts from a linear pre-deployment configuration to a helical post-deployment configuration by the biasing action of the spring wire element. Upon inflation of the elongated balloon element, the prosthesis unwinds, dynamically engaging and stretching the stomach wall, reducing the intragastric space, and slowing down gastric emptying, thus promoting a feeling of satiety, which may result in weight loss.

Abstract: The invention relates generally to methods and systems for irrigating or capturing particulates during heart pump implantation, and more specifically relates to irrigating, capturing, and removing particulates that may be released when coring a patient's heart tissue. In one aspect, a method for capturing particulates during heart pump implantation is provided that includes inserting a removable particulate capture device into a patient's heart prior to a coring procedure upon the patient's heart. The removable particulate capture device includes an expandable basket movable between collapsed and expanded configurations. The method further includes expanding the expandable basket to the expanded configuration from the collapsed configuration when the removable particulate capture device is positioned within the patient's heart to capture the particulates released during the coring procedure.

Abstract: The present invention includes an embolic protection device comprising a catheter having a self-expanding embolic filter that is disposed around the catheter proximal to a distal portion, wherein the embolic filter comprises a frame, and the frame defines an opening of the embolic filter that faces the distal end of the catheter; a deployment mechanism that is disposed around at least a portion of the catheter, wherein the deployment mechanism is longitudinally movable with respect to the catheter, the deployment mechanism is configured to contain the embolic filter in a collapsed configuration, and the embolic filter is configured to self-expand upon the longitudinal retraction of the deployment mechanism; and a wire coupled to the frame for expanding the size or diameter of the embolic filter opening.

Abstract: A filter device includes: a core member; a push member; first, second and third tubes; a first restriction member disposed on the first tube and configured to restrict a pushing movement of the third tube to the distal direction; a filter; a ring fixed to the opening; first and second wires, wherein the filter is configured in such a manner that the diameter of the opening is reduced by deformation of the shape of the ring, the deformation being caused by the first wires and the second wires when the push member fixed to the core member is pushed with the push member in contact with the second tube, and in such a manner that the diameter of the opening is expanded by restoration of the ring to the original shape, the restoration being caused by separating the push member fixed to the core member from the second tube.

Abstract: An embolic coil is formed by being spirally wound by an element wire and is filled into an aneurysm. The embolic coil includes: a first coil portion, in which a large-diameter coil portion wound to have a large diameter D1 and a small-diameter coil portion wound to have a diameter D2 smaller than the large-diameter coil portion are arranged in a plurality of coils and alternately in a longitudinal direction Y of the embolic coil. A second coil portion is wound to be continuous with the first coil portion and to have a surface flatter than the first coil portion.

Abstract: A method for suctioning an object in a blood vessel, the method comprising: inserting an expansion portion connected to a shaft portion on a distal portion of the shaft portion into the blood vessel; expanding the expansion portion in the blood vessel; inserting a suction catheter along the shaft portion into the blood vessel; reciprocating at least the expansion portion or the suction catheter relative to each other along an axial axis of the shaft portion; and suctioning the object with the suction catheter.

Abstract: A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device.

Abstract: Medical devices including optical connector cable assemblies are disclosed. An optical connector cable assembly may include an optical connector cable having a first optical fiber extending therefrom. The optical connector cable may include a distal connector configured to connect to a guidewire. The distal connector may include an inner housing and a guidewire locking mechanism. The distal connector may also include an actuator. Actuation of the actuator may move the inner housing from a first position to a second position. When the inner housing is in the first position the guidewire locking mechanism is configured to secure the guidewire and the guidewire is rotatable with respect to the optical connector cable. When the inner housing is in the second position the guidewire locking mechanism is in an open state for receiving or removing the guidewire.

Abstract: An apparatus for treating an aneurysm includes an occlusion element configured to be releasably coupled to an elongate delivery shaft and having a distal end, a proximal end, and a longitudinal axis extending between the distal end and the proximal end, the occlusion element configured to be delivered in a collapsed configuration and further configured to expand to an expanded configuration, the occlusion element comprising an inverted mesh tube having an outer layer and an inner layer, the outer layer transitioning to the inner layer at an inversion fold located at or adjacent the distal end of the occlusion element, the inversion fold defining an inner diameter, the occlusion element further comprising a maximum outer diameter, wherein the inner diameter is between about 35% to about 85% of the maximum outer diameter, and wherein an outer diameter of the occlusion element increases along the longitudinal axis to the maximum outer diameter.

Abstract: Shortly after completing a thrombectomy procedure, a temporary carotid filter can be deployed downstream of an occlusion not treated by the thrombectomy (e.g. a carotid lesion having plaque buildup), and the temporary carotid filter can remain in place during the patient's recovery period following the ischemic stroke until a procedure to treat the remaining occlusion is completed and antiplatelet therapy is administered. The temporary carotid filter can anchor in place while deployed with or without being tethered to a wire extending through the patient's Femoral Artery.

Abstract: An occlusive device comprising a braided component which can be inserted into a blood vessel and a delivery system for delivering said occlusive device is described.

Abstract: An implant detachment system is described which utilizes a catheter utilizing an LC or tank circuit with an inductor and capacitor. The catheter electrically interacts with an implant delivered through the catheter to detach the implant.

Abstract: A left atrial appendage (LAA) closure (1) and a system (6) for delivering the LAA closure are disclosed. The LAA closure (1) includes supporting struts (11), wherein the supporting struts (11) are distributed peripherally around a first hub (10) and extend outward, the supporting strut (11) bifurcates at a first position (110) into a left branch (111) and a right branch (112). The left branch (111) of each supporting strut (11) and the right branch (112) of an adjacent supporting strut join each other at a second position (113) and extend distally to form a distal end. The LAA closure further includes a supporting rod (12) between adjacent supporting struts (11) which ensures stability, absence of irregular deformation and lateral slippage, of the LAA closure (1). With the supporting rods (12) between the adjacent supporting struts (11), the LAA closure (1) forms a dense mesh which imparts high overall strength of the LAA closure (1).