Abstract: A system and method for treating a skin target area includes one or more RF electrodes adapted to provide RF energy for heating the skin target area. A quasi-fractional light unit is adapted to provide optical spots of energy having a wavelength not greater than 1200 nm for heating the skin target area. The RF electrodes and the quasi-fractional light unit are configured to provide energy essentially simultaneously to the skin target area to heat the entire target in non-uniform manner by way of a matrix of spots each having a predetermined diameter.

Abstract: A blood testing apparatus has a test member and a laser source configured to produce a wound from which blood flows. The laser source produces at least a cutting wavelength, and a coagulation wavelength. Electronics for analysis and a display are provided. The test member, laser source, electronics and display form a glucose monitoring system that is integrated in a single apparatus.

Abstract: There is provided a probe type living body tissue removing device comprising a probe unit having a probe formed in a capillary tube shape and an opening hole portion for internally aspirating a living body tissue, and also having a dissection device arranged within the probe and dissecting the living body tissue aspirated into the probe from the opening hole portion of the probe; wherein an aspiration force supplying device for supplying aspiration force to the probe unit, and a dissection driving source supplying device for supplying power or energy for fulfilling a function of the dissection device to the probe unit are connected to the probe unit; and the probe type living body tissue removing device dissects, and aspirates and removes the living body tissue by the dissecting means while the probe is inserted into the living body tissue and the living body tissue is aspirated through the opening hole portion; and a plurality of the opening hole portions of the probe are arranged.

Abstract: Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus . IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions.

Abstract: Methods of treating a subject for a cardiac arrhythmia are provided. Aspects of the methods include thoracoscopically producing a cardiac Cox maze III set of lesions in cardiac tissue of the subject in a manner sufficient to treat the subject for the cardiac arrhythmia.

Abstract: A first link and a second link are articulated relative to each other via a joint coupled between the first and second links. A shape-sensing optical fiber is used to sense a position of the first link and the second link relative to each other. The fiber passes through a channel having an opening defining a lip and extending from the first link toward the joint. The lip has a curved surface that begins substantially tangent to a wall of the channel, and during bending of the optical fiber, the optical fiber is positioned tangent to the curved surface of the lip.

Abstract: One or more treatment parameters are determined for a cornea reshaping procedure. The one or more treatment parameters are selected so as to reduce an amount of collagen shrinkage in a cornea of a patient's eye caused by the cornea reshaping procedure. For example, the one or more treatment parameters could be selected so as to minimize an amount of stromal collagen shrinkage in the cornea of the patient's eye caused by the cornea reshaping procedure. As another example, the cornea reshaping procedure could include irradiating multiple spots on the cornea of the patient's eye, where each spot is associated with an amount of stromal collagen. The one or more treatment parameters could be selected so that no more than 1% or 5% of the stromal collagen in the irradiated spots undergoes clinically significant shrinkage as a result of the cornea reshaping procedure.

Abstract: An intracerebral probe (11) comprising a first part (20) with laser or cryogenic treatment means and further comprising a hollow second part (22) surrounding the first, the first part sliding inside the second part along its longitudinal axis (A); and a plurality of detectors (16) distributed along a portion of the second part (22) in such a manner as to be capable of identifying a brain dysfunction zone along the longitudinal axis (A) of the second part. Advantageously, the probe presents a lateral treatment window enabling the action of the treatment means to be directed. The invention also provides a kit and a treatment system including such a probe, and the use thereof of treating cell dysfunctions that give rise to neurological or psychiatric symptoms.

Abstract: Devices and methods for thermally-mediated treatment of blood vessels to elicit an immune response to cause rapid endothelial growth over at least portions of an implant or stent to prevent adverse events such as restenosis. Devices and methods for thermally-mediated treatment to inhibit contraction of vessels to elicit an immune response to cause rapid endothelial growth over at least portions of a stent to prevent adverse events such as restenosis.

Abstract: Embodiments of the present invention include a laser catheter that includes a catheter body, a light guide, and a distal tip that extends beyond the exit aperture of the light guide. In some embodiments, an imaging device is disposed on the distal tip such that the imaging device is distal relative to the exit aperture of the light guide. In some embodiments, the imaging device can be gated to record images during and/or slightly beyond periods when the laser catheter is not activated.

Abstract: Prostate treatment using fluid stream to resect prostate tissue, thereby relieving symptoms of conditions such as BPH, prostatitis, and prostatic carcinoma. A device having a fluid delivery element is positioned within a lumen of the urethra within the prostate. A fluid stream is directed outwardly from the fluid delivery element toward a wall of the urethral lumen. The fluid delivery element is moved to scan the fluid stream over the wall to remove a volume of tissue surrounding the lumen. The fluid may be combined with therapeutically active substances or with substances that increase resection efficiency. Fluid force may be adjusted to provide selective tissue resection such that soft tissue is removed while harder tissue is left undamaged. In order to gain a working space within the urethra, another fluid may be introduced to insufflate the urethra in the region of treatment.

Abstract: Guided ablation instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias, including atrial fibrillation. In one aspect of the invention, a percutaneous catheter is disclosed with an endoscope positionable in the instrument's distal end region to obtain an image. The image allows the clinician to determine whether contact has been achieved (or blood has been cleared from an ablative energy transmission path) before ablation begins or while ablation is occurring. In one embodiment, percutaneous ablation catheters are disclosed having at least one central lumen and one or more balloon structures at the distal end region of the instrument. Also disposed in the distal end region are an illuminating light source and an endoscope capable of collecting sufficient light to relay an image to the user. The instruments can further include an ablation element.

Abstract: Facilitating a dermatologic treatment by providing a light source emitting optical radiation and having a plurality of wavelengths, reflecting some of the emitted optical radiation back to the light source to enhance the brightness of the optical radiation, and applying at least some of the enhanced optical radiation to a skin surface to facilitate a dermatologic treatment.

Abstract: Embodiments of methods and systems for hair treatment are disclosed. According to various embodiments, light is used to shave, trim, or otherwise modify hair shafts.

Abstract: A closure device having evertable arms for capturing and everting tissue and method for its use with an invasive scope, such as an endoscope, for full-thickness closure of perforations and leaks in the walls of an intraluminal bodily space.

Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.

Abstract: A phototherapy device includes a light source; a light emanation block; and a heat exchanger for the dissipation of heat from one or more heat loads associated with the device. Heat may be transferred via the heat exchanger from the light source independently of the dissipation of heat from one or more of the other device heat loads. Substantially thermally isolated heat transfer regions may be provided, and such regions may be maintained at different operating temperatures, to control the transfer of heat in conjunction with a phototherapy method and to promote efficient and enhanced device operation and performance.

Abstract: An energy delivery device for administering tissue therapy is presented including a housing and an elongated body extending distally from the housing. The energy delivery device also includes a first lumen extending a length of the elongated body, the first lumen configured to facilitate application of thermal treatment to a target region of tissue and a second lumen extending the length of the elongated body, the second lumen configured to facilitate infusion of hydrogels embedded with stem cells to the target region of tissue thermally treated. The energy delivery device further includes a third lumen configured to facilitate delivery of ultraviolet (UV) light to the target region of tissue for curing the hydrogels. A distal end of the elongated body is positioned in proximity to the target region of tissue for enabling successive introduction of the thermal treatment, infusion of the hydrogels, and delivery of the UV light.

Abstract: A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.

Abstract: A method and device for light color therapy, which is a method for simultaneously exposing specific surface regions of the human body to light of specific but possibly different frequencies, temporal characteristics and polarization. The device is constructed to match anatomical details of the human body such as to apply the simultaneous local light exposures to the desired body regions and to compensate for possible movement of the head, thereby minimizing the time required for a single treatment.

Abstract: The invention relates to a micro-organism reducing device, comprising a radiation device which is provided with a light source, a photosensitive substance which treats the area to be treated and is irradiated by said light source. The aim of said invention is to configure said device in such a way that it is possible to carry out an efficient and controllable treatment by means of operationally low-cost and easily handling apparatus. For this purpose, the inventive device comprises at least one applicator provided with a fiber-optic waveguide. In addition, said applicator and radiation device respectively comprise corresponding liaison bodies contacting one of them in such a way that the light from the light source is emitted towards the treated area by means of the fiber-optic waveguide.

Abstract: Disclosed herein is a modulator of vascular permeability using pulsed laser and a method for modulating vascular permeability using the same. More specifically, because the pulsed laser effectively induces vascular permeabilization, effectively delivers intravascular materials into tissues and minimizes insult to the tissues by the induced vascular permeabilization, and locally targets a subcutaneous tissue for noninvasive modulation due to its nonlinearity, it may be usefully used for modulation of permeability.

Abstract: A method of high intensity laser treatment for stimulating regeneration of living biological tissue in a patient by applying a pulsed laser beam to a skin of the patient in need of the treatment.

Abstract: A flashlamp device having a small diameter waveguide is disclosed for use in localized dermatological applications. A preferred waveguide has a curvilinear wall surface. The waveguide is supported by a plurality of spaced apart thermally-conductive elements in contact with the curvilinear wall surface allowing sufficient cooling of the waveguide while minimizing the amount of high angle light stripped from the waveguide at points of contact with the contact elements.

Abstract: An integral laser imaging and coagulation apparatus, and associated systems and methods that allow an ophthalmologist to perform laser retinal surgical procedures with an integral laser imaging and coagulation apparatus disposed at a first (i.e. local) location from a control system disposed at a second (i.e. remote) location, e.g., a physician's office. In some embodiments, communication between the integral laser imaging and coagulation apparatus and control system is achieved via the Internet®.

Abstract: Steerable and flexibly curved probes are provided, primarily for surgical applications. A probe with flexible distal portion is inserted through an incision or cannula and the flexible distal portion may be selectively bent or steered using a guide wire. The guide wire is extended through the probe on a radially offset axis, and affixed at its distal end to the distal end of the flexible distal portion. The curvature of the nitinol wire is induced by extending or retracting the wire from the proximal end of the flexible distal portion while the distal end of the guide wire remains affixed to the distal end of the probe. The guide wire is activated by a finger-actuated mechanism. A further embodiment is provided in which the guide wire is fixed at both ends of the flexible distal portion of the probe and has a normally curved conformation, and assumes such conformation after insertion through a straight cannula. Other embodiments and applications are similarly disclosed.

Abstract: An apparatus having an excitation source that includes at least one laser diode and also having a handpiece with a disposable, bendable tip cannula is disclosed.

Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.

Abstract: A system/method for destruction/ablation of stones, calculi or other hard substances using laser is disclosed. Lithotripsy is particularly benefitted. The system comprises a diode laser source, one or more optical fibers and a liquid delivery system creating a liquid environment around stones (calculi). At least one emitted wavelength is highly absorbed in surrounding/covering medium, causing evaporation and cavitation effects that lead to stone/calculi destruction. Different radiation configurations may be used. in one embodiment continuous radiation is used to create sparkler-less plasma bubbles to destroy hard substances. In another embodiment high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally device/method is used with another wavelength having absorption in water e.g. 980 nm. Safer/improved methods/system provide enhanced lithotripsy treatments with shorter treatment times to destroy a wider range of stones with less tissue damage risk.

Abstract: Inducing thrombolysis of thermally induced thrombus occurring during endovenous ablation of varicose veins by introducing an optical fiber laser deliver device with optical fiber portion and with an energy emitting tip at its distal end into the varicosed vein to be treated, emitting pulsed, laser energy with sufficient energy to close and destroy varicose veins to the emitting tip of the optical fiber laser delivery device, thereby inducing laser thrombolysis of coagulated blood which accumulates at the energy emitting tip of the fiber when the fiber is caused to emit energy in the presence of uncoagulated blood and minimizing adverse effects associated with thermally induced thrombus within a varicose vein.

Abstract: System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

Abstract: A non-contact laser handpiece contains optical components modified to provide a high-density uniform laser beam at a distance from the handpiece that minimizes effects of back reflection.

Abstract: The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: Methods and devices are provided for performing various procedures using interchangeable end effectors. In general, the methods and devices allow a surgeon to remotely and selectively attach various interchangeable surgical end effectors to a shaft located within a patient's body, thus allowing the surgeon to perform various procedures without the need to remove the shaft from the patient's body. In an exemplary embodiment, multiple end effectors can be introduced into a body cavity. The end effectors can be disassociated or separate from one another such that they float within the body cavity. A distal end of a shaft can be positioned within the body cavity and it can be used to selectively engage one of the end effectors. In particular, the device can be configured to allow each end effector to be remotely attached and detached from the distal end of the shaft.

Abstract: The present invention is based on the seminal discovery that targeted immunomodulatory antobodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antobodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of cancer cells is recognized as immune tolerance. Such immuno-suppressive mechanisms include immunosuppressive cytokines (for example, Transforming growth factor beta (TGF-?)) and regulatory T cells and/or immunosuppressive myeloid dendritic cells (DCs). By conteracting tumor-induced immune tolerance, the present invention provides effective compositions and methods for cancer treatment, optional in combination with another existing cancer treatment.

Abstract: Eye-safe, low-power-density, Class 1 or Class 3R laser treatment systems for medical applications are disclosed. Systems having controlled power and stray irradiation can meet laser safety requirements according to IEC 60825-1:2007 or equivalent for eye-safe rating; classification as laser-Class 1 or as laser-Class 3R. Laser system comprises a diode laser source, an optical fiber probe, means for detecting and identifying said optical probe and means to ensure that laser power transmitted from the fiber probe is limited to pre-specified maximum power level per application; laser wavelength; emission characteristics; probe characteristics; limiting values according to applied safety regulations. Device can identify the connected optical fiber probe to exclude using non-conforming optical fiber probes and/or to limit maximum output to optical powers in compliance with laser safety regulations. System preferably operates at a wavelength of 1400 nm or higher.

Abstract: A cardiac ablation instrument capable of removing blood from a treatment area is provided. The instrument includes a catheter configured to deliver a distal end thereof to a patient's heart. The instrument can also include an expandable element coupled to the distal end of the catheter wherein the expandable member is configured to be positioned adjacent a target area thereby defining a treatment area between the expandable member and the target area. Further, the instrument can include an irrigation mechanism configured to dispense an irrigation fluid from the catheter thereby displacing blood from the treatment area. Additionally, the instrument includes an energy emitter configured to deliver energy to tissue within the treatment area. The instrument can also include a contact sensor configured to determine the presence of such blood within the treatment area. Methods for ablating tissue are also provided.

Abstract: In one embodiment, an apparatus may include an optical fiber that may have a surface non-normal to a longitudinal axis of a distal end portion of the optical fiber. The surface may define a portion of an interface configured to redirect electromagnetic radiation propagated from within the optical fiber and incident on the interface to a direction offset from the longitudinal axis. The apparatus may also include a doped silica cap that may be fused to the optical fiber such that the surface of the optical fiber may be disposed within a cavity defined by the doped silica cap.

Abstract: A photostimulation apparatus may include: a membrane for insertion into a living body; and at least one cell disposed on the membrane. Each cell may include a first light source for irradiating light to a photosensitive material in the living body. Further, a photostimulation apparatus may include: a membrane for insertion into a living body; and at least one first light source disposed on the membrane for irradiating light to a photosensitive material in the living body. Since the photostimulation apparatus is placed on the surface of cortex or dura, it may minimize damage of the brain tissue and may activate and/or inhibit a large area simultaneously using light.

Abstract: Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

Abstract: Methods and devices for treating nasal airways are provided. Such devices and methods may improve airflow through an internal and/or external nasal valve, and comprise the use of mechanical re-shaping, energy application and other treatments to modify the shape, structure, and/or air flow characteristics of an internal nasal valve, an external nasal valve or other nasal airways.

Abstract: Non-ablative skin resurfacing can include generating electromagnetic radiation having a wavelength of about 1920 nm to about 1950 nm and a fluence of about 3 J/cm2 to about 6 J/cm2. The electromagnetic radiation is delivered to a target region of skin to cause thermal injury to the epidermis in the target region sufficient to elicit a healing response that produces a substantially improved skin condition without detachment of the epidermis (e.g., within 3 days of treatment).

Abstract: An infrared wound healing unit having a layer of an optically and radiographically transparent flexible heating element which, when powered, emits heat that serves to heal a wound according to monochromatic infrared energy (MIRE) treatment of the wound. This infrared wound healing unit is arranged so that: (a) heat emitted from the layer of an optically and radiographically transparent flexible heating element passes to a wound of a patient to treat the wound, (b) the wound of the patient that is being treated can be viewed while heat is emitted from the layer of an optically and radiographically transparent flexible heating element to treat the wound, (c) the wound is accessible for other forms of treatment, and (d) the infrared wound healing unit remains secured to the patient while the wound is being viewed or treated.

Abstract: Steerable and flexibly curved probes are provided, primarily for A surgical applications. A probe with flexible distal portion is inserted through an incision or cannula and the flexible distal portion may be selectively bent or steered using a guide wire. The guide wire is extended through the probe on a radially offset axis, and affixed at its distal end to the distal end of the flexible distal portion. The curvature of the nitinol wire is induced by extending or retracting the wire from the proximal end of the flexible distal portion while the distal end of the guide wire remains affixed to the distal end of the probe. The guide wire is activated by a finger-actuated mechanism. A further embodiment is provided in which the guide wire is fixed at both ends of the flexible distal portion of the probe and has a normally curved conformation, and assumes such conformation after insertion through a straight cannula. Other embodiments and applications are similarly disclosed.

Abstract: Disclosed are a germicidal system and method for deactivating pathogens on the surface of a bodily extremity protected by a prophylactic covering substantially opaque to UV-C radiation. The device includes an enclosure having one or more openings through which the extremity can be inserted. The enclosure contains a radiation source configured to produce germicidal radiation having a wavelength of about 253.7 nm. The openings are configured relative to the radiation source such that the inserted extremity is in close proximity to the radiation source. The prophylactic covered extremity is preferably a gloved hand thereby sanitizing the surface of the glove. The extremity inserted is preferably exposed for a predetermined period of time to ensure a desired level of sanitization. Optionally, the device can include detectors to determine the position of the hand, the spread of the fingers, and whether the hand is covered by a glove.

Abstract: Optical energy-based methods and apparatus for sealing vascular tissue involves deforming vascular tissue to bring different layers of the vascular tissue into contact each other and illuminating the vascular tissue with a light beam having at least one portion of its spectrum overlapping with the absorption spectrum of the vascular tissue. The apparatus may include two deforming members configured to deform the vascular tissue placed between the deforming members. The apparatus may also include an optical system that has a light source configured to generate light, a light distribution element configured to distribute the light across the vascular tissue, and a light guide configured to guide the light from the light source to the light distribution element. The apparatus may further include a cutting member configured to cut the vascular tissue and to illuminate the vascular tissue with light to seal at least one cut surface of the vascular tissue.

Abstract: Disclosed are vertebroplasty methods that include cauterizing an inner cavity of a vertebra of a mammal, such as a human, and injecting bone cement into the vertebra. Systems and kits for performing such methods are also disclosed.

Abstract: Ablation methods and instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias and the like. Percutaneous ablation instruments in the form of coaxial catheter bodies are disclosed having at least one central lumen therein and having one or more balloon structures at the distal end region of the instrument. The instruments include an energy emitting element which is independently positionable within the lumen of the instrument and adapted to project radiant energy through a transmissive region of a projection balloon to a target tissue site to form a series of lesions on the target tissue.

Abstract: An ECG-prep scan is used to set an optimum time phase in both systole and diastole of the heart. At each of the different time phases, an imaging scan is started to acquire a plurality of sets of echo data. An artery/vein visually separated blood flow image is produced from the echo data. The imaging scan uses a half-Fourier technique, for example. This provides high-quality blood flow images with shorter scan time, without injecting a contrast medium. Additionally, with a readout gradient pulse applied substantially parallel with a direction of slowly flowing blood, a scan is performed in synchronism with an optimally determined cardiac time phase. The readout gradient pulse has a dephasing pulse for enhancing differences in a flow void effect depending on blood flow velocities. This enables slow-speed flows, such as blood flows in the inferior limb, to be depicted without fail.