Abstract: The invention relates to an irradiation device (1) and a method for the treatment of acne and acne scars, comprising at least one source of radiation (2), the source of radiation emitting at least one broadband spectrum in the wavelength range of 320-at least 540 nm and the radiation source (2) being pulse-operable and/or movable relatively to the area to be irradiated, the pulse energy being between 0.05-10 J/cM2 and the peak irradiation intensity being between 0.5 W/cm2 and 100 kW/cm2.

Abstract: The present invention relates to a system and method for the photomodulation of living tissue. When photomodulated, living tissue will exhibit bioactivation or bioinhibition according to the present invention and, when using the disclosed sources of narrowband multichromatic radiation can cause significant dermatologic advantages such as hair removal, hair growth stimulation, wrinkle reduction, acne reduction and scar removal, vitiligo, etc. The present invention has application to non-dermatological medical treatments including tumor growth inhibition, cell regeneration, the stimulation of tissue in organs, etc.

Abstract: The present invention provides a method for diagnosing or treating prostatic tissue in a human or animal patient which comprises sensitizing the prostatic tissue with an effective amount of a photosensitive composition which accumulates in the prostatic tissue and exposing the sensitized tissue to a source of light energy for a predetermined time and intensity sufficient to cause cellular and/or tissue function of the sensitized prostatic tissue to diminish or cease.

Abstract: In a device for treating blood vessels with a laser, the laser provides a beam in a wavelength range from 750 to 850 nm, preferably 805 nm. The device has a measuring unit which measures the concentration of a chromophore (preferably indocyanine green) administered to the patient in the patient's blood vessels. The device further comprises a control unit which controls the power of the laser in a contrary sense to the measured concentration.

Abstract: An ophthalmic surgery apparatus comprising a system for observing an anterior portion of an eye, and an optical system for irradiating a laser beam for treatment to the eye, the apparatus is a corneal surgery apparatus irradiating the laser beam to a cornea and ablating a surface thereof, the apparatus comprising a moving device for moving the optical system relatively against the eye, an illuminating device for illuminating a large area of the anterior portion of the eye, a photoelectric transducing device having a two-dimensional light sensing plane, for sensing distribution of light volume of the anterior portion of the eye, a pupil position sensing device for sensing the position of a pupil, a control device for controlling the moving device based on sensed results, a tracking signal generating device for generating a signal to track movement of the eye, whereby the moving device is controlled by the control device so as to track movement of the eye by inputting a signal generated by the tracking signal g

Abstract: A method of treating a surface by laser ablation to modify selected regions of the surface, while other regions of the surface not to be substantially ablated are protected from the laser beam by a masking fluid, wherein the masking fluid comprises a solution of a pharmaceutically acceptable pyrido benzoxazine compound or derivative thereof effective as a masking agent.

Abstract: A system for non-invasive treatment of a patient's trabecular meshwork to treat primary open-angle glaucoma, exfoliation glaucoma and pigmentary glaucoma wherein the meshwork can be clogged with cellular debris and other accumulations. The system and technique applies energy directly to media within clogged spaces in a patient's trabecular meshwork to increase aqueous outflow facility by (i) localization of microimplantable bodies carrying a selected exogenous chromophore in deeper regions of the trabecular meshwork and (ii) irradiation of the microimplantables with a selected coherent wavelength having a power level and pulse duration that is strongly absorbed by the exogenous chromophore. The chromophores are preferably carried in uniform nanocystalline particles having an average diameter ranging from about 0.5 nm to 20 nm.

Abstract: Laser surgery is controlled by interferometry.

Abstract: A system for producing preferential damage to hair exiting mammalian skin. A agent having an average diameter for enabling the agent to penetrate the hair duct is selected. The agent is designed to attach to, or become physically incorporated into, the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent has an electromagnetic radiation absorption characteristic which enables the agent to absorb a first wavelength of electromagnetic radiation from a skin-penetrating electromagnetic radiation source, such as a laser. The agent is applied to the skin so that the agent penetrates the skin and attaches to or becomes physically incorporated into the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent is exposed to the first wavelength of electromagnetic radiation and absorbs the first wavelength of electromagnetic radiation.

Abstract: A process and apparatus for removing cataractous lens tissue (22) in a human or animal eye and substitution of the lens with replacement material (48) utilizing an apparatus in the form of a surgical instrument (42). The process contains the steps of injecting a therapeutic photosensitive agent (20) into the lens tissue, allowing a predetermined amount of time to elapse, exposing the photosensitive substance to a source of light energy at a predetermined period of time and wavelength causing the lens to microfracture and liquefy. Following this procedure the liquefied lens tissue is evacuated with the surgical instrument, and a lens replacement material is injected into the lens capsule (28) through the surgical instrument to reconstitute the intralenticular space and serve as a refracting medium. The dual cannula surgical instrument consists of a hollow cylindrical body (52) with a parallel shank (58) and a tapered section (60) on one end.

Abstract: A controlled process for thoroughly curing light-activated surgical and dental composites is presented using a hand-held, self-contained, cordless, rechargeable laser instrument. At least one micro laser generates focused single wavelength blue laser light of at most 480 nm, and enhances efficiency and control of curing. The process of use includes switching from stand-by mode to curing mode of operation of the instrument to save time during surgical and dental procedures.

Abstract: A long pulsed dye laser device for selective photothermolysis comprises at least two pulsed dye lasers, such as flash lamp excited dye lasers, each generating corresponding pulsed laser beams successively in time. These laser can be coordinated by a synchronizer that sequentially triggers the lasers. A combining network merges the pulse laser beams into a combined beam and a delivery system conveys the combined pulse laser beam to a patient. An example of a delivery device is a single optical fiber. This invention enables production of the necessary pulse widths, on the order of 2 msec, which can not be achieved by individual dye lasers, generally lower than 0.8 msec. Also disclosed is a selective photothermolysis method. This method comprises irradiating a tissue section of a patient with a pulsed laser beam having a changing color across a time period of the pulse.

Abstract: A method for the laser photoablation of ocular lens tissue comprises the steps of determining a volume of the lens tissue to be photoablated and directing a pulsed, infrared laser beam at the volume with an amount of energy effective for photoablating the determined region without causing substantial damage to surrounding tissue regions. The laser beam is initially directed at a focal point below an anterior surface of the ocular lens and such focal point is moved towards the ocular lens anterior surface in order to ablate the determined volume. The laser is preferably an Nd:YLF laser operating at a frequency of about 1053 nanometers and a pulse repetition rate of about 1000 Hertz with a pulse width of about 60 picoseconds. Each pulse has an energy of about 30 microjoules. The laser operates with a focused beam diameter of about 20 microns and operates with a “zone of effect” of no greater than about 50 microns.

Abstract: Methods and apparatus are disclosed for forming annular lesions in tissue. The methods include introduction of an optical apparatus proximate to a tissue site, via, for example, a catheter. The optical apparatus includes a pattern-forming optical wave guide in communication with a light transmitting optical fiber. Energy is transmitted through the optical fiber, such that radiation is propagated through the optical fiber and the wave guide projects an annular light pattern, e.g., a circle or a halo.

Abstract: A method is provided for treating a patient having a disorder, wherein the method includes irradiating a tissue surface of the patient with at least one laser beam, automatically monitoring the tissue, and automatically controlling the at least one laser beam to adjust and/or terminate the treatment in a therapeutically effective manner. The method noninvasively determines in real-time the irradiance and/or radiant exposure of a target tissue at a predetermined depth below the tissue surface by detecting the radial dependence of light remitted from the tissue surface. Preferably, the method employs a near-infrared light laser beam and a visible laser light beam in combination. An apparatus for performing the method is also provided.

Abstract: A photonic scanning and delivery system capable of controllable transmission of light energy to an irregularly shaped treatment area are disclosed. The desired uniformity (controllability) of light energy application is ensured by a tracking device, which monitors the position of the radiation applicator and thereby prevents over- or under-radiation. The system employs a light energy delivery hand-piece. By these means, structures in the lower dermis are irradiated. Because of the large size of the treatment area, damage to surface tissue is avoided. The hand-piece can operate while in contact with the treatment surface. Treatment surfaces include non-medical work sites. Alternatively, the hand-piece can operate in a non-contact mode. The system can also be used in non-medical applications such as UV curing.

Abstract: Infrared surgical photoablation instruments are disclosed for creating lesions in tissue, including cardiac tissue for treatment of arrhythmias and other diseases. The hand held instruments are especially useful in open chest or port access cardiac surgery for rapid and efficient creation of curvilinear lesions to serve as conduction blocks. Photoablative instruments are disclosed that emit radiation at a wavelength in a range from about 800 nm to about 1000 nm, and preferably emit at a wavelength in a range of about 915 nm to about 980 nm. Radiation at a wavelength of 915 nm or 980 nm is commonly preferred, in some applications, because of the optimal absorption of infrared radiation by cardiac tissue at these wavelengths.

Abstract: A long pulsed dye laser device for selective photothermolysis comprises at least two pulsed dye lasers, such as flash lamp excited dye lasers, each generating corresponding pulsed laser beams successively in time. These laser can be coordinated by a synchronizer that sequentially triggers the lasers. A combining network merges the pulse laser beams into a combined beam and a delivery system conveys the combined pulse laser beam to a patient. An example of a delivery device is a single optical fiber. This invention enables production of the necessary pulse widths, on the order of 2 msec, which can not be achieved by individual dye lasers, generally lower than 0.8 msec. Also disclosed is a selective photothermolysis method. This method comprises irradiating a tissue section of a patient with a pulsed laser beam having a changing color across a time period of the pulse.

Abstract: Near-infrared selective photothermolysis for the treatment of ectatic blood vessels, for example, blood vessels of a portwine stain birthmark. This technique is especially applicable to deeper lying blood vessels in view of the better penetration of the near infrared light. Consequently, vessels are below a dermal/epidermal boundary can be reached. Near-infrared is defined as a range of approximately 700 to 1,200 nm. The optimal colors are near 760 or between 980 to 990 nm for most populations.

Abstract: In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

Abstract: An ophthalmological laser surgery system having a laser, associated elements for delivering an optical beam from the laser to a patient eye location, a control unit for controlling the operation of the system and a system input/output device, is enabled by a patient data card. The data card originally contains both patient background and system control information, which is transferred to the control unit via the input/output device. During system operation, newly generated information, such as laser beam power, is stored in the data card to provide an independent record of the surgical procedure actually performed. After one use, the data card is invalidated to prevent further use.

Abstract: A dual wavelength surgical laser system for performing laser surgery on living tissue with a minimum amount of collateral tissue damage is disclosed.

Abstract: Mammalian hair is depilated by pulsing a laser source emitting radiation in the range 600 to 1500 nm, each pulse having a duration of 1 &mgr;sec to 200 msec, and a radiation exposure dose of 2 to 25 J/cm2, so as to irradiate successive zones of a treatment area of a patient's skin and thereby destroy subdermal biological material associated with hair growth.

Abstract: A long pulse alexandrite laser for treating dermatological specimens is disclosed. The use of alexandrite allows operation in the near-infrared, specifically in a 50 nm range surrounding 755. Infrared in this range allows good penetration while still achieving an acceptable ratio of hemoglobin to melanin absorption. In operation, the laser generates pulses having a durations between 5 and 100 msec and fluences between 10 and 50 J/cm2. A light delivery system is provided that transmits the laser light output pulse to dermatological targets of a patient. The invention is also directed to a hair removal system. Here, it is desirable to use an index-matching application on the skin sections to be treated, and a visual indicator is thermo- or photo-responsive or otherwise responsive to the laser light pulse to generate a visible change. Also, the invention is directed to a combined sclerotherapy and light treatment method and kit for unwanted veins.

Abstract: A method is provided for treating a patient having a disorder, wherein the method includes irradiating a tissue surface of the patient with at least one laser beam, automatically monitoring the tissue, and automatically controlling the at least one laser beam to adjust and/or terminate the treatment in a therapeutically effective manner. The method noninvasively determines in real-time the irradiance and/or radiant exposure of a target tissue at a predetermined depth below the tissue surface by detecting the radial dependence of light remitted from the tissue surface. Preferably, the method employs a near-infrared light laser beam and a visible laser light beam in combination. An apparatus for performing the method is also provided.

Abstract: An apparatus is described for use in combination with a noninvasive ophthalmological method for cornea reshaping in order to correct ocular refractive errors such as myopia (nearsightedness), hyperopia (farsightedness), and astigmatism. This apparatus is called a coupler and it is made of a material which is substantially transparent to the light energy used to reshape the cornea. The coupler conducts heat from the anterior portion of the cornea during the heating of the stroma by the light energy. The reshaping is enhanced by the coupler as it has a corneal engaging surface with a radius of curvature which approximates the desired emmetropic shape of the cornea. In addition to being a heat sink and template for the eye, the coupler also acts as a positioner and restrainer of the eye by attaching itself to the eye via an annular suction ring. Finally, the coupler also acts as a mask to prevent accidental exposure of the central optic zone to any light energy during the cornea reshaping procedure.

Abstract: A laser system in which the gain medium is an excited YAP:Nd crystal. The system is configured so that the crystal produces a twin laser beam comprising wavelengths at both 1079 nm and 1340 nm with substantial intensities at each wavelength. Optical components are described which establish the desired ratio of the intensities of the light at each of the two wavelengths. These ratios, I1079 nm/I1340 nm, may vary from about 0.1 to a preferred embodiment of the invention a kit including a YAP:Nd crystal and a specially coated output coupler is provided for converting an existing Nd:YAG laser system to a twin light laser capable of producing the above described twin laser beam.

Abstract: The therapeutic laser apparatus (10) includes at least two wands (50) connected to a controller (210) and radiation source (155) via fiber optic cables (135, 140). The controller (210) and source (155) include at least two infrared wavelength solid-state diode (“SSD”) lasers (165) and at least two visible wavelength SSD aiming lasers (170). The apparatus (10) further includes a combiner (195) configured to maintain the electromagnetic radiation from one infrared SSD laser (165) coincident with one visible light SSD aiming laser (170). In the method according to the invention, the visible light SSD aiming laser (170) is used as a pointer so that an operator can position wands (125, 130) adjacent to the skin of a mammal whereby the beams (127, 132) of infrared treatment lasers (165) intersect at a region (B) inside the body (A) of the mammal.

Abstract: Apparatus for monitoring the presence of one or more chromophores in a tissue sample, comprises a light source for projecting light to illuminate an area of such tissue sample, a photo-receptor for receiving light remitted by the illuminated area of tissue, and spectroscopic analyser means for monitoring the remitted light, a comparator having means for comparing variations in the intensity and spectral characteristics of the remitted light with respect to the intensity and spectral characteristics of the projected light at different wavelengths and with a record of the intensity and spectral characteristics of light remitted by a reference sample of such tissue and means for emitting a control signal in response to any such variations. Methods of analyzing tissue histology, especially skin histology, are discussed, and a mathematical model is proposed for the analysis and comparison of the remitted light with a reference sample.

Abstract: A device for treating bodily substances, in particular for intraocular cataract surgery, said device comprising a laser beam source, for example, an erbium YAG laser, which produces pulsed laser radiation at wavelengths in the infrared range. A control device comprises a first arrangement (38, 48) by means of which an acceptable range for the pulse energy and/or pulse length and/or pulse frequency can be predetermined before an operation, and a second arrangement (34, 36, 40, 42) by means of which the pulse energy and/or pulse length and/or pulse frequency can be adjusted to a given value or values within the predetermined range during the operation.

Abstract: A method for the laser photoablation of ocular lens tissue comprises the steps of determining a volume of the lens tissue to be photoablated and directing a pulsed, infrared laser beam at the volume with an amount of energy effective for photoablating the determined region without causing substantial damage to surrounding tissue regions. The laser beam is initially directed at a focal point below an anterior surface of the ocular lens and such focal point is moved towards the ocular lens anterior surface in order to ablate the determined volume. The laser is preferably an Nd:YLF laser operating at a frequency of about 1053 nanometers and a pulse repetition rate of about 1000 Hertz with a pulse width of about 60 picoseconds. Each pulse has an energy of about 30 microjoules. The laser operates with a focused beam diameter of about 20 microns and operates with a “zone of effect” of no greater than about 50 microns.

Abstract: Systems, methods and apparatus for performing selective ablation of a corneal surface of an eye to effect a desired corneal shape, particularly for correcting a hyperopic/astigmatic condition by laser sculpting the corneal surface to increase its curvature. In one aspect of the invention, a method includes the steps of directing a laser beam onto a corneal surface of an eye, and changing the corneal surface from an initial curvature having hyperopic and astigmatic optical properties to a subsequent curvature having correctively improved optical properties. Thus, the curvature of the anterior corneal surface is increased to correct hyperopia, while cylindrical volumetric sculpting of the corneal tissue is performed to correct the astigmatism. The hyperopic and astigmatic corrections are preferably performed by establishing an optical correction zone on the anterior corneal surface of the eye, and directing a laser beam through a variable aperture element designed to produce a rectangular ablation (i.e.

Abstract: An apparatus and technique for transscleral light-mediated biostimulation of the trabecular plates of a patient's eye in a treatment for glaucoma or ocular hypertension. The apparatus includes; (i) a working end geometry for contacting the anterior surface of the sclera and cornea to insure that a laser emission reaches the trabecular meshwork from a particular location on the anterior surface of the sclera, (ii) a laser energy source providing a wavelength appropriate for absorption beneath the anterior scleral surface to the depth of the trabecular plates, and (iii) a dosimetry control system for controlling the exposure of the laser emission at the particular spatial locations. The device uses a light energy source that emits wavelengths in the near-infrared portion of the spectrum, preferably in the range of about 1.30 &mgr;m to 1.40 &mgr;m or from about 1.55 &mgr;m to 1.85 &mgr;m.

Abstract: An interventional device uses light to diagnose and treat tissue regions near the surface. A high intensity ultraviolet light is used. The interventional device includes a housing adapted for placement inside a body and a flash lamp placed inside the housing. The flash lamp is capable of generating high intensity ultraviolet light.

Abstract: The present invention provides an improved method of removing fluids, gases or other biomolecules, or delivering a pharmaceutical composition, through the skin of a patient without the use of a sharp or needle. The method includes the step of irradiating the stratum corneum, an applied pharmaceutical or an absorbing material, using a laser. By selection of parameters, the laser irradiates the selected material or tissue to create pressure gradients, plasma, cavitation bubbles, or other forms of tissue ablation or alteration. These methods increase the diffusion of pharmaceuticals into, or fluids, gases or other biomolecules out of, the body. For this invention, a pharmaceutical composition can be applied to the skin before or after laser irradiation.

Abstract: A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating tool and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen.

Abstract: Low level laser therapy apparatus for treatment of various tissue injuries is described. In one embodiment, the apparatus includes a handheld laser probe coupled to a control unit for selecting and controlling laser energy dosage from about 1 joule/point to about 10 joules/point. The apparatus emits laser energy at a wavelength from about 630 nm to about 904 nm, with a mean power output of between about 100 mW to about 500 mW. The apparatus further includes an access control mechanism to limit operability to trained personnel.

Abstract: A method for altering iris pigmentation in a human, thereby altering perceived iris color of a first iris from a first iris color to a second iris color. The method comprises preselecting one or more than one laser capable of generating one or more than one laser beam which will selectively remove iris pigment of a first preselected pigment color from the first iris, and applying the one or more than one laser beam to the first iris of a first iris color to remove iris pigment of the first preselected pigment color.

Abstract: The invention features improvements in PRK procedures that relate to preventing non-uniform removal of material from the corneal surface. It has been realized that photoablation by-products resulting during the PRK procedure can affect the accuracy and the predictability of the procedure. Under certain conditions, the plume of photoablation by-products that have left the corneal surface can non-uniformly redeposit onto the ablation area and thus affect the uniformity of subsequent material removal. The plume of photoablation by-products, in the space above the corneal surface, can also non-uniformly affect the escape of further photoablation products from the surface. In addition to the plume effects, it has been realized that the hydration level of the corneal tissue during the PRK procedure can vary over the ablation area and likewise non-uniformly affect the PRK procedure.

Abstract: A method for the treatment of bone fracture using low level laser therapy. A therapist applies pressure adequate to blanch the skin at a treatment point over a site of bone fracture, and applies laser energy having a wavelength of about 630 nm to about 904 nm, with laser apparatus having a mean power output of about 100 mW to about 500 mW, at a dosage of over 1 joule/point to about 10 joules/point. Treatment times, total dosage, and number of treatment points are determined by the therapist trained in LLLT.

Abstract: Device for the removal of tissue from the cornea of an eye using a laser beam generator for the production of a laser beam, an optical device by which, during the removal of the tissue, the laser beam is directed onto the cornea to be treated, with an approximately circular beam cross section and a defined removal profile for the beam energy that is transferred to the corneal tissue to be removed, and a control device for controlling the optical device so that a removal profile is formed that, in the radial section starting out from the central beam axis 2 of the beam cross section, has an approximately spherical or concave course in an internal radial region 3 that changes into a point of inflection 4 and an outer radial region 5 that joins the point of inflection 4, with a convex or monotonic decreasing course.

Abstract: Output optical energy pulses including relatively high energy magnitudes at the beginning of each pulse are disclosed. As a result of the relatively high energy magnitudes which lead each pulse, the leading edge of each pulse includes a relatively large slope. This slope is preferably greater than or equal to 5. Additionally, the full-width half-max value of the output optical energy distributions are between 0.025 and 250 microseconds and, more preferably, are about 70 microseconds. A flashlamp is used to drive the laser system, and a current is used to drive the flashlamp. A flashlamp current generating circuit includes a solid core inductor which has an inductance of 50 microhenries and a capacitor which has a capacitance of 50 microfarads.

Abstract: A diode pumped, multi axial mode, intracavity doubled laser has at least two resonator mirrors that define a resonator cavity. A Nd:YVO4 laser crystal and a LBO doubling crystal are positioned in the resonator cavity. A diode pump source supplies a pump beam to the laser crystal and produces a laser crystal beam with at least three axial modes that are incident on the doubling crystal. A frequency doubled output beam is generated with an output power of at least 1 watt.

Abstract: Mammalian hair is depilated using a laser source capable of emitting pulse radiation, each pulse having a duration of 1 microsecond to 1 millisecond, and having a wavelength in the range of 600 to 1500 nanometers. The radiation exposure dose is preferably between 2 and 25 J/cm2. A selected area of a subject's skin is irradiated by the pulsed radiation, the area having a plurality of irradiation zones. The laser source is successively pulsed so as to irradiate successive zones of the treatment area with the radiation, so as to destroy subdermal biological material associated with hair growth.

Abstract: A method for altering iris pigmentation in a human, thereby altering perceived iris color of a first iris from a first iris color to a second iris color. The method comprises preselecting one or more than one laser capable of generating one or more than one laser beam which will selectively remove iris pigment of a first preselected pigment color from the first iris, and applying the one or more than one laser beam to the first iris of a first iris color to remove iris pigment of the first preselected pigment color.

Abstract: The therapeutic laser apparatus includes at least two wands connected to a controller and radiation source via fiber optic cables. The controller and source include at least two infrared wavelength solid-state diode (“SSD”) lasers and at least two visible wavelength SSD aiming lasers. The apparatus further includes a combiner configured to maintain the electromagnetic radiation from one infrared SSD laser coincident with one visible light SSD aiming laser. In the method according to the invention, the visible light SSD aiming laser is used as a pointer so that an operator can position the wands adjacent to the skin of a mammal whereby the beams of infrared treatment lasers intersect at a region inside the body of the mammal.

Abstract: A method for modifying the curvature of a live cornea via use of a laser. The live cornea is first separated into first and and second opposed internal surfaces. Next, a laser beam is directed onto at least one of the first and second internal surfaces, or both. The laser beam is used to either ablate a three-dimensional portion of the cornea for making the cornea less curved, or coagulate a portion of the cornea for making the cornea more curved. In one embodiment, the central portion of the cornea is ablated to make the cornea less curved. In another embodiment, a plurality of internal tunnels are formed and ablated in the cornea to make the cornea less curved. In yet another embodiment, a plurality of internal points in the cornea forming the periphery of a circle are coagulated to make the cornea more curved. In place of the laser, a mechanical device can be used, such as a drill tip.

Abstract: A system and method for modification of tissue. The system and method utilize a disposable sample cell that contains a chemical mixture capable of photoinitiation. Upon photoinitiation, a chemical reaction creates electromagnetic radiation that is readily absorbed by a desired portion of tissue. The absorption of energy creates heat which can be controlled to result in predetermined modifications to the tissue.

Abstract: This invention teaches an optical source (10) for performing photomedicine. The optical source includes a Nd:YLF laser (12) having an output providing light having a wavelength of 1.053 micrometers; a frequency doubler (13) that is optically coupled to the laser output for converting a portion of the light to frequency doubled light, the frequency doubler having an output providing frequency doubled light having a wavelength of 526.5 nm; coupled to the output of the frequency doubler, a unit (14) for shifting the frequency doubled light to light having a longer wavelength of about 630 nm; and means (16) for conveying the light having the longer wavelength to the region of tissue. In one embodiment of this invention the shifting unit includes a device for performing stimulated Raman scattering of the frequency doubled light.

Abstract: Transocular and periocular laser delivery system for treatment of eye diseases wherein a fiberoptic element is passed through a perforation made either by paracentesis of eyeball encapsulating tissue (i.e.—cornea, sclera) or by the fiberoptic element itself so that the fiber actually penetrates into a chamber therein. The penetrating fiber end is then juxtaposed to the tissue to be treated while the external fiberoptic end is coupled either to an excimer laser emitting ultraviolet radiation (in the range of 193 to 351 nanometers) or to certain lasers emitting infrared radiation, the radiated pulses therefrom being directed through the transocularly-positioned fiber to be absorbed by chromophores in the target tissue (cataractous lens, trabecular meshwork, vitreous membranes, tear duct occlusion) where removal by photoablation is effected.